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Abstract: Knot filtered embedded contact homology was first introduced by Hutchings in 2015; it has been computed for the standard transverse unknot in irrational ellipsoids by Hutchings and for the Hopf link in lens spaces via a quotient by Weiler. While toric constructions can be used to understand the ECH chain complexes of many contact forms adapted to open books with binding the unknot and Hopf link, they do not readily adapt to general torus knots and links. In this paper, we generalize the definition and invariance of knot filtered embedded contact homology to allow for degenerate knots with rational rotation numbers. We then develop new methods for understanding the embedded contact homology chain complex of positive torus knotted fibrations of the standard tight contact 3‐sphere in terms of their presentation as open books and as Seifert fiber spaces. We provide Morse–Bott methods, using a doubly filtered complex and the energy filtered perturbed Seiberg–Witten Floer theory developed by Hutchings and Taubes, and use them to compute the knot filtered embedded contact homology, for odd and positive.

During the COVID-19 pandemic, telehealth delivery of psychological care services expanded to meet the needs of people with cancer. This study examined psychologists' attitudes toward using telehealth during the pandemic peak in a tertiary oncology hospital. Semi-structured interviews were conducted with ten psychologists who used telehealth to deliver psychological services. Thematic analysis was conducted to identify themes in the interview data. Themes identified: (1) increased uptake and attendance of psychology sessions was due to greater accessibility of services; (2) clinicians reported ease of communication and building of rapport when using telehealth; and (3) clinicians perceived differences in the psychotherapeutic process when sessions were delivered via telehealth compared to in-person. Clinicians expressed high satisfaction with delivering telehealth psychological support for oncology patients. Implications for Psychosocial Providers: Oncology services that are considering developing or expanding a telehealth psychology service can facilitate this by ensuring a reliable technological platform and providing training and/or support to staff and patients. Clinicians should also use their clinical judgment to decide if a patient is appropriate for telehealth-delivered psychological care or if a mix of modalities is more ideal. [ABSTRACT FROM AUTHOR]

Abstract Dominant X-linked diseases are uncommon due to female X chromosome inactivation (XCI). While random XCI usually protects females against X-linked mutations, Rett syndrome (RTT) is a female neurodevelopmental disorder caused by heterozygous MECP2 mutation. After 6-18 months of typical neurodevelopment, RTT girls undergo a poorly understood regression. We performed longitudinal snRNA-seq on cerebral cortex in a construct-relevant Mecp2e1 mutant mouse model of RTT, revealing transcriptional effects of cell type, mosaicism, and sex on progressive disease phenotypes. Across cell types, we observed sex differences in the number of differentially expressed genes (DEGs) with 6x more DEGs in mutant females than males. Unlike males, female DEGs emerged prior to symptoms, were enriched for homeostatic gene pathways in distinct cell types over time and correlated with disease phenotypes and human RTT cortical cell transcriptomes. Non-cell-autonomous effects were prominent and dynamic across disease progression of Mecp2e1 mutant females, indicating that wild-type-expressing cells normalize transcriptional homeostasis. These results advance our understanding of RTT progression and treatment.

Summary: Large-scale analysis of single-cell gene expression has revealed transcriptomically defined cell subclasses present throughout the primate neocortex with gene expression profiles that differ depending upon neocortical region. Here, we test whether the interareal differences in gene expression translate to regional specializations in the physiology and morphology of infragranular glutamatergic neurons by performing Patch-seq experiments in brain slices from the temporal cortex (TCx) and motor cortex (MCx) of the macaque. We confirm that transcriptomically defined extratelencephalically projecting neurons of layer 5 (L5 ET neurons) include retrogradely labeled corticospinal neurons in the MCx and find multiple physiological properties and ion channel genes that distinguish L5 ET from non-ET neurons in both areas. Additionally, while infragranular ET and non-ET neurons retain distinct neuronal properties across multiple regions, there are regional morpho-electric and gene expression specializations in the L5 ET subclass, providing mechanistic insights into the specialized functional architecture of the primate neocortex.

Describes literacies for young children in language and the visual and musical arts and possible connections between them. Provides examples to show how children's arts literacies are laden with social, emotional, and cultural meanings. Considers the potential of using arts literacies in early childhood education, focusing on the Reggio Emilia approach. (KB)

Describes the evolution and features of the instructional approach developed in Reggio Emilia, Italy preschools. Notes how the approach incorporates multiple intelligences, developmentally appropriate instruction, and an emergent curriculum; how children are encouraged to express their ideas in more than one medium or "language"; and how cultural beliefs, community, and families promote quality. (HTH)

El proceso de valoración de atractivos y recursos turísticos constituyen entre otros aspectos de relevancia, la base del desarrollo turístico y componente significativo en el ámbito de la gestión de destinos turísticos. La presente investigación tiene como objetivo analizar cuantitativamente los atractivos y recursos turísticos para la gestión de destinos de sol y playa en Manabi aplicando la técnica multivariada de análisis factorial exploratorio. La metodología de investigación es de tipo descriptiva y correlacional, con el propósito de realizar un análisis factorial exploratorio por componentes principales. En consecuencia, entre los resultados alcanzados, se ha identificado un grupo de variables significativas para la caracterización del perfil del visitante a partir del análisis exploratorio de datos; así como, la demostración de la pertinencia y viabilidad práctica del análisis factorial exploratorio en la identificación de un conjunto de factores estructurados referidos a la oferta turística, atención al visitante, formación del personal y acciones de seguridad turística, entre otros. Como conclusiones derivadas del estudio, la cuantificación de atractivos y recursos turísticos ha contribuido al mejoramiento de programas de promoción turística rediseñados por el departamento de turismo cantonal localizados en los destinos de sol y playa seleccionados en la provincia de Manabí.

A discussão sobre cidades inteligentes tem sido pauta na academia, na gestão pública, no mercado, dentre outros. A literatura aponta que o objetivo de tais cidades passa pelo emprego das tecnologias para gerar melhoria na qualidade de vida dos cidadãos. Para tal as gestões municipais devem mobilizar diversas capacidades presentes dentro e fora da estrutura estatal. Uma vez que o Ranking Connected Smart Cities aponta a cidade de Porto Alegre como referência no contexto das cidades inteligentes, este trabalho avalia as capacidades técnico-administrativas e político-relacionais geradas pelos arranjos institucionais da Prefeitura de Porto Alegre. Os procedimentos metodológicos do estudo de caso incluem pesquisa documental, bibliográfica e entrevista. Os resultados indicam que os principais fatores que sustentam altos níveis de capacidade do estado para produzir políticas públicas de cidade inteligente são o elevado quantitativo de burocracia profissionalizada, a existência de mecanismos de coordenação e o espaço de participação social estabelecido no Movimento do Pacto Alegre.

Salmeterol may lose its effectiveness in preventing exercise-induced bronchoconstriction in asthma patients when it is taken long-term. Researchers measured lung function 30 minutes after the morning dose of salmeterol and nine hours later in 20 patients who took the drug or a placebo twice a day. Lung function was measured while the patients exercised on a stationary bicycle. Compared to placebo, the drug reduced the degree of bronchoconstriction, but as the 30-day study progressed, the drug became less effective.

Quesnel (QN) and Stikine (ST) arc terranes, which are less exotic than the oceanic crustal rocks of the Cache Creek terrane (CC), border the CC on the east, north and west. An arcuate belt of replaced continental margin rocks surround the terranes. The continental margin rocks are also found in Kootenay, Nisling and Yukon-Tanana terranes. The rocks exhibit isolated Sr-87/Sr-86 isopleths.

El turismo de sol y playa es la modalidad más atractiva para el turista al momento de planificar sus vacaciones. En este sentido, es necesario activar investigaciones que contribuyan a la sostenibilidad multidimensional de las comunidades costeras. El objetivo de este artículo es analizar el comportamiento de la producción científica del turismo sostenible en destinos de sol y playa. Para el estudio se consideró un total de 39 documentos obtenidos por medio de una ecuación en la base de datos Scopus, durante el período 2009-2019, donde se analizaron indicadores bibliométricos unidimensionales de productividad. Asimismo, se utilizaron indicadores bibliométricos multidimensionales de colaboración autoral y de coocurrencia de palabras clave utilizando el software VOSviewer. Los resultados apuntan a autores medianos productores con relaciones de colaboración de carácter global y un crecimiento sostenido de las publicaciones por año, siendo el inglés el idioma que prevalece. En concusión la investigación realizada permite conocer la evolución y áreas específicas de conocimiento en el campo de la sostenibilidad de playas, entre las cuales se encuentran: Gestión integral de playas, evaluación ambiental de playas, sistemas de certificación de playas, acondicionamiento ambiental, social y político para mitigar los impactos negativos del calentamiento global en las playas.

Abstract Multi-modal single cell RNA assays capture RNA content as well as other data modalities, such as spatial cell position or the electrophysiological properties of cells. Compared to dedicated scRNA-seq assays however, they may unintentionally capture RNA from multiple adjacent cells, exhibit lower RNA sequencing depth compared to scRNA-seq, or lack genome-wide RNA measurements. We present scProjection, a method for mapping individual multi-modal RNA measurements to deeply sequenced scRNA-seq atlases to extract cell type-specific, single cell gene expression profiles. We demonstrate several use cases of scProjection, including identifying spatial motifs from spatial transcriptome assays, distinguishing RNA contributions from neighboring cells in both spatial and multi-modal single cell assays, and imputing expression measurements of un-measured genes from gene markers. scProjection therefore combines the advantages of both multi-modal and scRNA-seq assays to yield precise multi-modal measurements of single cells.

Abstract Coralsnakes of the genus Micrurus are a diverse group of venomous snakes ranging from the southern United States to southern South America. Much uncertainty remains over the genus diversity, and understanding Micrurus systematics is of medical importance. In particular, the widespread Micrurus nigrocinctus spans from Mexico throughout Central America and into Colombia, with a number of described subspecies. This study provides new insights into the phylogenetic relationships within M. nigrocinctus by examining sequence data from a broad sampling of specimens from Mexico, Guatemala, Honduras, Nicaragua, Costa Rica, and Panama. The recovered phylogenetic relationships suggest that M. nigrocinctus is a species complex originating in the Pliocene and composed of at least three distinct species-level lineages. In addition, recovery of highly divergent clades supports the elevation of some currently recognized subspecies to the full species rank while others may require synonymization.

O presente artigo apresenta as principais mudanças na geração distribuída de energia elétrica no Brasil, contemplando a aprovação do novo marco legal (Lei 14.300/2022) do setor, que entrou em vigor em janeiro de 2022. Para responder à investigação no campo da geração de energia, a pesquisa conta com estudos bibliográficos, documentais, exploratório-descritiva e de natureza qualitativa. Parte-se da compreensão da nova legislação, que de certa forma apresenta maior segurança jurídica ao setor, assegura sustentabilidade econômica aos diferentes agentes do setor elétrico brasileiro. Desta forma, apesar de a mudança na legislação ser bastante recente, com desdobramentos em curso, com impactos a serem ainda melhor mensurados, concluiu-se que o novo marco legal equilibra o incentivo à geração distribuída e viabilidade técnico-econômica no médio e longo prazo ao sistema elétrico brasileiro, em especial às distribuidoras de energia elétrica. Abstract: This article presents the main changes in the distributed generation of electricity in Brazil, contemplating the approval of the new legal framework (Law 14.300/2022) for the area, which took its effect in January 2022.To answer the research in the field of energy generation, the research relies on bibliographic, documentary, exploratory-descriptive and qualitative studies. It starts from the understanding of the new legislation, which in a way provides greater legal certainty to the area, and ensures economic sustainability to the different agents of the Brazilian electricity sector. This way, despite the change in legislation being quite recent, with ongoing developments, and having impacts to be even better measured, it was concluded that the new legal framework balances the incentive for distributed generation and gives technical-economic feasibility in the medium and long term over Brazilian electric system, especially to electric energy distributors.