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1. PKM2 diverts glycolytic flux in dependence on mitochondrial one-carbon cycle

Author

Benzarti, Mohaned, Neises, Laura, Oudin, Anais, Krötz, Christina, Viry, Elodie, Gargiulo, Ernesto, Pulido, Coralie, Schmoetten, Maryse, Pozdeev, Vitaly, Lorenz, Nadia I., Ronellenfitsch, Michael W., Sumpton, David, Warmoes, Marc, Jaeger, Christian, Lesur, Antoine, Becker, Björn, Moussay, Etienne, Paggetti, Jerome, Niclou, Simone P., Letellier, Elisabeth, and Meiser, Johannes

Published
2024
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2. Serine metabolism is crucial for cGAS-STING signaling and viral defense control in the gut

Author

Becker, Björn, Wottawa, Felix, Bakr, Mohamed, Koncina, Eric, Mayr, Lisa, Kugler, Julia, Yang, Guang, Windross, Samuel J., Neises, Laura, Mishra, Neha, Harris, Danielle, Tran, Florian, Welz, Lina, Schwärzler, Julian, Bánki, Zoltán, Stengel, Stephanie T., Ito, Go, Krötz, Christina, Coleman, Olivia I., Jaeger, Christian, Haller, Dirk, Paludan, Søren R., Blumberg, Richard, Kaser, Arthur, Cicin-Sain, Luka, Schreiber, Stefan, Adolph, Timon E., Letellier, Elisabeth, Rosenstiel, Philip, Meiser, Johannes, and Aden, Konrad

Published
2024
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3. GAP43-dependent mitochondria transfer from astrocytes enhances glioblastoma tumorigenicity

Author

Watson, Dionysios C., Bayik, Defne, Storevik, Simon, Moreino, Shannon Sherwin, Sprowls, Samuel A., Han, Jianhua, Augustsson, Mina Thue, Lauko, Adam, Sravya, Palavalasa, Røsland, Gro Vatne, Troike, Katie, Tronstad, Karl Johan, Wang, Sabrina, Sarnow, Katharina, Kay, Kristen, Lunavat, Taral R., Silver, Daniel J., Dayal, Sahil, Joseph, Justin Vareecal, Mulkearns-Hubert, Erin, Ystaas, Lars Andreas Rømo, Deshpande, Gauravi, Guyon, Joris, Zhou, Yadi, Magaut, Capucine R., Seder, Juliana, Neises, Laura, Williford, Sarah E., Meiser, Johannes, Scott, Andrew J., Sajjakulnukit, Peter, Mears, Jason A., Bjerkvig, Rolf, Chakraborty, Abhishek, Daubon, Thomas, Cheng, Feixiong, Lyssiotis, Costas A., Wahl, Daniel R., Hjelmeland, Anita B., Hossain, Jubayer A., Miletic, Hrvoje, and Lathia, Justin D.

Published
2023
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4. Mitochondria preserve an autarkic one-carbon cycle to confer growth-independent cancer cell migration and metastasis

Author

Kiweler, Nicole, Delbrouck, Catherine, Pozdeev, Vitaly I., Neises, Laura, Soriano-Baguet, Leticia, Eiden, Kim, Xian, Feng, Benzarti, Mohaned, Haase, Lara, Koncina, Eric, Schmoetten, Maryse, Jaeger, Christian, Noman, Muhammad Zaeem, Vazquez, Alexei, Janji, Bassam, Dittmar, Gunnar, Brenner, Dirk, Letellier, Elisabeth, and Meiser, Johannes

Published
2022
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5. CNSC-15. MITOCHONDRIA TRANSFER VIA GLIOMA-ASTROCYTE NETWORK MICROTUBES REPROGRAMS TUMOR CELLS FOR ENHANCED TUMORIGENICITY

Author

Watson, Dionysios, primary, Bayik, Defne, additional, Storevik, Simon, additional, Moreino, Shannon, additional, Sprowls, Samuel, additional, Han, Jianhua, additional, Augustsson, Mina, additional, Lauko, Adam, additional, Palavalasa, Sravya, additional, Rosland, Gro, additional, Troike, Katie, additional, Tronstad, Karl, additional, Wang, Sabrina, additional, Sarnow, Katharina, additional, Kay, Kristen, additional, Lunavat, Taral, additional, Silver, Daniel, additional, Dayal, Sahil, additional, Joseph, Justin, additional, Mulkearns-Hubert, Erin, additional, Ystaas, Lars, additional, Deshpande, Gauravi, additional, Guyon, Joris, additional, Zhou, Yadi, additional, Magaut, Capucine, additional, Seder, Juliana, additional, Neises, Laura, additional, Williford, Sarah, additional, Meiser, Johannes, additional, Scott, Andrew J, additional, Sajjakulnukit, Peter, additional, Mears, Jason, additional, Bjerkvig, Rolf, additional, Chakraborty, Abhishek, additional, Daubon, Thomas, additional, Cheng, Feixiong, additional, Iavarone, Antonio, additional, Lyssiotis, Costas, additional, Wahl, Daniel, additional, Hjelmeland, Anita, additional, Hossain, Jubayer, additional, Miletic, Hrvoje, additional, and Lathia, Justin, additional

Published
2023
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6. Formate promotes invasion and metastasis in reliance on lipid metabolism

Author

Delbrouck, Catherine, primary, Kiweler, Nicole, additional, Chen, Oleg, additional, Pozdeev, Vitaly I., additional, Haase, Lara, additional, Neises, Laura, additional, Oudin, Anaïs, additional, Fouquier d’Hérouël, Aymeric, additional, Shen, Ruolin, additional, Schlicker, Lisa, additional, Halder, Rashi, additional, Lesur, Antoine, additional, Schuster, Anne, additional, Lorenz, Nadja I., additional, Jaeger, Christian, additional, Feucherolles, Maureen, additional, Frache, Gilles, additional, Szpakowska, Martyna, additional, Chevigne, Andy, additional, Ronellenfitsch, Michael W., additional, Moussay, Etienne, additional, Piraud, Marie, additional, Skupin, Alexander, additional, Schulze, Almut, additional, Niclou, Simone P., additional, Letellier, Elisabeth, additional, and Meiser, Johannes, additional

Published
2023
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7. Formate Promotes Invasion and Metastasis by Activating Fatty Acid Synthesis and Matrix Metalloproteinases

Author

Delbrouck, Catherine, primary, Kiweler, Nicole, additional, Pozdeev, Vitaly I., additional, Neises, Laura, additional, Oudin, Anaïs, additional, Schuster, Anne, additional, d’Hérouël, Aymeric Fouquier, additional, Shen, Ruolin, additional, Halder, Rashi, additional, Lesur, Antoine, additional, Ogris, Christoph, additional, Lorenz, Nadia I., additional, Jaeger, Christian, additional, Ronellenfitsch, Michael W., additional, Piraud, Marie, additional, Skupin, Alexander, additional, Niclou, Simone P., additional, Letellier, Elisabeth, additional, and Meiser, Johannes, additional

Published
2023
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8. PKM2 diverts glycolytic flux in dependence on mitochondrial one-carbon cycle

Author

Benzarti, Mohaned, primary, Oudin, Anais, additional, Viry, Elodie, additional, Gargiulo, Ernesto, additional, Schmoetten, Maryse, additional, Neises, Laura, additional, Pulido, Coralie, additional, Lorenz, Nadia I., additional, Ronellenfitsch, Michael W., additional, Sumpton, David, additional, Warmoes, Marc, additional, Jaeger, Christian, additional, Lesur, Antoine, additional, Moussay, Etienne, additional, Paggetti, Jerome, additional, Niclou, Simone P., additional, Letellier, Elisabeth, additional, and Meiser, Johannes, additional

Published
2023
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9. Metabolic plasticity of serine metabolism is crucial for cGAS/STING-signalling and innate immune response to viral infections in the gut

Author

Becker, Björn, primary, Wottawa, Felix, additional, Bakr, Mohamed, additional, Koncina, Eric, additional, Mayr, Lisa, additional, Kugler, Julia, additional, Yang, Guang, additional, Windross, Samuel J, additional, Neises, Laura, additional, Mishra, Neha, additional, Harris, Danielle, additional, Tran, Florian, additional, Welz, Lina, additional, Schwärzler, Julian, additional, Bánki, Zoltán, additional, Stengel, Stephanie T, additional, Ito, Go, additional, Krötz, Christina, additional, Coleman, Olivia I, additional, Jaeger, Christian, additional, Haller, Dirk, additional, Paludan, Søren R, additional, Blumberg, Richard, additional, Kaser, Arthur, additional, Cicin-Sain, Luka, additional, Schreiber, Stefan, additional, Adolph, Timon E., additional, Letellier, Elisabeth, additional, Rosenstiel, Philip, additional, Meiser, Johannes, additional, and Aden, Konrad, additional

Published
2022
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10. Mitochondrial One-Carbon Flux has a Growth-Independent Role in Promoting Breast Cancer Metastasis

Author

Kiweler, Nicole, primary, Delbrouck, Catherine, additional, Neises, Laura, additional, Pozdeev, Vitaly, additional, Soriano-Baguet, Leticia, additional, Xiang, Feng, additional, Benzarti, Mohaned, additional, Haase, Lara, additional, Schmoetten, Maryse, additional, Jaeger, Christian, additional, Noman, Muhammad, additional, Vazquez, Alexei, additional, Janji, Bassam, additional, Dittmar, Gunnar, additional, Brenner, Dirk, additional, Letellier, Elisabeth, additional, and Meiser, Johannes, additional

Published
2021
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11. Ascorbate kills breast cancer cells by rewiring metabolism via redox imbalance and energy crisis

Author

Ghanem, Ali, Melzer, Anna Maria, Zaal, Esther, Neises, Laura, Baltissen, Danny, Matar, Omar, Glennemeier-Marke, Hannah, Almouhanna, Fadi, Theobald, Jannick, Abu El Maaty, Mohamed A, Berkers, Celia, Wölfl, Stefan, Ghanem, Ali, Melzer, Anna Maria, Zaal, Esther, Neises, Laura, Baltissen, Danny, Matar, Omar, Glennemeier-Marke, Hannah, Almouhanna, Fadi, Theobald, Jannick, Abu El Maaty, Mohamed A, Berkers, Celia, and Wölfl, Stefan

Abstract

The idea to use megadoses of ascorbate (vitamin C) for cancer treatment has recently been revived. Despite clear efficacy in animal experimentation, our understanding of the cellular and molecular mechanisms of this treatment is still limited and suggests a combined oxidative and metabolic mechanism behind the selective cytotoxicity of ascorbate towards cancerous cells. To gain more insight into the cellular effects of high doses of ascorbate, we performed a detailed analysis of metabolic changes and cell survival of both luminal and basal-like breast cancer cells treated with ascorbate and revealed a distinctive metabolic shift virtually reversing the Warburg effect and triggering a severe disruption of redox homeostasis. High doses of ascorbate were cytotoxic against MCF7 and MDA-MB231 cells representing luminal and basal-like breast cancer phenotypes. Cell death was dependent on ascorbate-induced oxidative stress and accumulation of ROS, DNA damage, and depletion of essential intracellular co-factors including NAD+/NADH, associated with a multifaceted metabolic rewiring. This included a sharp disruption of glycolysis at the triose phosphate level, a rapid drop in ATP levels, and redirection of metabolites toward lipid droplet accumulation and increased metabolites and enzymatic activity in the pentose phosphate pathway (PPP). High doses of ascorbate also inhibited the TCA cycle and increased oxygen consumption. Together the severe disruptions of the intracellular metabolic homeostasis on multiple levels "redox crisis and energetic catastrophe" consequently trigger a rapid irreversible cell death.

Published
2021

12. Ascorbate kills breast cancer cells by rewiring metabolism via redox imbalance and energy crisis

Author

Sub Biomol.Mass Spectrometry & Proteom., Veterinaire biochemie, dB&C FR-RMSC RMSC, Biomolecular Mass Spectrometry and Proteomics, Al het onderzoek van de faculteit Diergeneeskunde, Ghanem, Ali, Melzer, Anna Maria, Zaal, Esther, Neises, Laura, Baltissen, Danny, Matar, Omar, Glennemeier-Marke, Hannah, Almouhanna, Fadi, Theobald, Jannick, Abu El Maaty, Mohamed A, Berkers, Celia, Wölfl, Stefan, Sub Biomol.Mass Spectrometry & Proteom., Veterinaire biochemie, dB&C FR-RMSC RMSC, Biomolecular Mass Spectrometry and Proteomics, Al het onderzoek van de faculteit Diergeneeskunde, Ghanem, Ali, Melzer, Anna Maria, Zaal, Esther, Neises, Laura, Baltissen, Danny, Matar, Omar, Glennemeier-Marke, Hannah, Almouhanna, Fadi, Theobald, Jannick, Abu El Maaty, Mohamed A, Berkers, Celia, and Wölfl, Stefan

Published
2021

13. Mitochondria preserve an autarkic one-carbon cycle to confer growth-independent cancer cell migration and metastasis

Author

Kiweler, Nicole, primary, Delbrouck, Catherine, additional, Pozdeev, Vitaly I., additional, Neises, Laura, additional, Soriano-Baguet, Leticia, additional, Eiden, Kim, additional, Xian, Feng, additional, Benzarti, Mohaned, additional, Haase, Lara, additional, Koncina, Eric, additional, Schmoetten, Maryse, additional, Jaeger, Christian, additional, Noman, Muhammad Zaeem, additional, Vazquez, Alexei, additional, Janji, Bassam, additional, Dittmar, Gunnar, additional, Brenner, Dirk, additional, Letellier, Elisabeth, additional, and Meiser, Johannes, additional

Published
2021
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15. Ascorbate kills breast cancer cells by rewiring metabolism via redox imbalance and energy crisis

Author

Ghanem, Ali, primary, Melzer, Anna Maria, additional, Zaal, Esther, additional, Neises, Laura, additional, Baltissen, Danny, additional, Matar, Omar, additional, Glennemeier-Marke, Hannah, additional, Almouhanna, Fadi, additional, Theobald, Jannick, additional, Abu el Maaty, Mohamed A., additional, Berkers, Celia, additional, and Wölfl, Stefan, additional

Published
2021
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17. A Bioorthogonal Click Chemistry Toolbox for Targeted Synthesis of Branched and Well‐Defined Protein–Protein Conjugates

Author

Baalmann, Mathis, primary, Neises, Laura, additional, Bitsch, Sebastian, additional, Schneider, Hendrik, additional, Deweid, Lukas, additional, Werther, Philipp, additional, Ilkenhans, Nadja, additional, Wolfring, Martin, additional, Ziegler, Michael J., additional, Wilhelm, Jonas, additional, Kolmar, Harald, additional, and Wombacher, Richard, additional

Published
2020
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19. Protocol using ex vivomouse brain slice culture mimicking in vivoconditions to study tumor growth and cell motility of glioblastoma cells

Author

Neises, Laura, Delbrouck, Catherine, Schuster, Anne, Rezaipour, Mahsa, Eiden, Kim, Oudin, Anais, Fabian, Carina, Niclou, Simone P., Golebiewska, Anna, and Meiser, Johannes

Abstract

Herein, we present an ex vivoapproach to study glioblastoma (GBM) cell motility in viable mouse brain slice cultures, closely mimicking in vivofeatures. We detail the preparation and culturing of mouse brain slices followed by tumor cell injection, allowing for the analysis of different aspects of the cellular migration and invasion process. Our assay facilitates testing diverse perturbations including genetic modifications and treatments in a physiological context. Thus, the protocol provides a compromise between in vitroassays and in vivomodels.

Published
2024
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20. Protocol using ex vivo mouse brain slice culture mimicking in vivo conditions to study tumor growth and cell motility of glioblastoma cells.

Author

Neises L, Delbrouck C, Schuster A, Rezaipour M, Eiden K, Oudin A, Fabian C, Niclou SP, Golebiewska A, and Meiser J

Abstract

Herein, we present an ex vivo approach to study glioblastoma (GBM) cell motility in viable mouse brain slice cultures, closely mimicking in vivo features. We detail the preparation and culturing of mouse brain slices followed by tumor cell injection, allowing for the analysis of different aspects of the cellular migration and invasion process. Our assay facilitates testing diverse perturbations including genetic modifications and treatments in a physiological context. Thus, the protocol provides a compromise between in vitro assays and in vivo models. For complete details on the use and execution of this protocol, please refer to Delbrouck et al. 1 and Schuster et al. 2 ., Competing Interests: Declaration of interests The authors declare no competing interests., (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)

Published
2024
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