2,483 results on '"Neipp"'
Search Results
2. General application of the genetic algorithm to the estimation of the Liquid Crystal Director in PA-LC devices
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Colomina Jaume, Sirvent-Verdú Joan Josep, Pérez-Bernabeu Andrés, Lloret Tomás, Rodríguez-Nieto Belén, Neipp Cristian, Beléndez Augusto, and Francés Jorge
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Physics ,QC1-999 - Abstract
The study of liquid crystal (LC) director distribution is an important area of research in materials science and technology. Parallel-aligned liquid crystal (PA-LC) devices have been extensively studied due to their applications in liquid crystal displays, optical devices, and sensors. Estimating the LC director distribution is a critical step in designing and optimising PA-LC devices. This work shows the results derived from apply-ing novel optimisation techniques to estimate the liquid crystal (LC) director distribution in parallel-aligned liquid crystal (PA-LC) devices. Moreover, the genetic algorithm (GA) has been applied and compared with the minimisation of the Frank-Oseen free energy through the Euler-Lagrange equations. The GA is a stochastic optimisation technique that can effectively explore the search space and find the global optimum. Overall, this study’s results demonstrate the GA’s effectiveness in estimating the LC director distribution in PA-LC devices. This approach can improve the performance and design of liquid crystal displays, optical devices, and sensors. Furthermore, it can be extended to other fields where the optimisation of complex systems is required. Further research is needed to optimise the GA parameters and to explore its potential in other applications.
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- 2023
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3. Manufacturing reflection holographic couplers for see-through applications recorded in photopolymers without prisms: An experimental validation
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Sirvent-Verdú J.J., Bravo J.C., Colomina-Martínez J., Piñol-Galera C., Nájar G., Neipp C., Francés J., Gallego S., and Beléndez A.
- Subjects
Physics ,QC1-999 - Abstract
In the present work, the viability of a novel recording geometry to produce reflection holographic couplers is analyzed. Recalling the idea of previous works, photopolymers are used as the recording material, as they are well-suited for the intended see-through application. Moreover, Kogelnik’s theory fundamentals give us the proper background to examine the proposed design, where no prisms or microlenses arrays are used. Aiming to support the analysis, we provide experimental evidence that the produced gratings exhibit the correct properties to work as a coupler.
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- 2023
- Full Text
- View/download PDF
4. Determinación de las constantes ópticas y el espesor de materiales holográficos
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Beléndez, A., Ortuño, M., Gallego, S., Beléndez, T., Neipp, C., and Pascual, I.
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Holographic recording materials ,Capas delgadas ,Constantes ópticas ,Materiales de registro holográfico ,Clay industries. Ceramics. Glass ,TP785-869 - Abstract
A technique to evaluate the refractive index, the absorption coefficient and the thickness of holographic recording materials is presented. The materials are in the form of a thin layer of film deposited on a thick glass plate. The experimental reflectances of p-polarized light are measured as a function of the incident angle, and the values of refractive index, thickness and absorption coefficient of the layer are obtained using the theoretical equation for reflectance. As examples, holographic silver halide emulsions and photopolymers are analyzed. The agreement between the calculated reflectances, using the thickness and refractive index obtained, and the measured reflectances is satisfactory.Se presenta una técnica experimental para determinar el índice de refracción, el coeficiente de absorción y el espesor de materiales de registro holográfico. Los materiales están depositados como capas finas sobre una lámina planoparalela de vidrio. Se determina experimentalmente la reflectancia en función del ángulo de incidencia para luz polarizada linealmente paralela al plano de incidencia, de modo que los valores del índice de refracción, el coeficiente de absorción y el espesor se obtienen ajustando la ecuación de la reflectancia teórica a los datos experimentales. Como ejemplos se han analizado emulsiones fotográficas y fotopolímeros, obteniéndose un buen ajuste entre la función teórica y los datos experimentales.
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- 2004
5. Estudio y caracterización de nuevas emulsiones de haluro de plata como materiales de registro holográfico
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Neipp, C., Beléndez, A., and Pascual, I.
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Holography ,holographic recording materials ,photographic emulsions ,photosensitive processing ,Holografía ,materiales de registro holográfico ,emulsiones fotográficas ,procesos fotosensibles ,Clay industries. Ceramics. Glass ,TP785-869 - Abstract
One of the most interesting techniques for the production of holographic optical elements is silver halide sensitised gelatin (SHSG). It combines the high sensitivity of photographic emulsions with the well-known low scattering and high diffraction efficiencies corresponding to dichromated gelatin. In this work we made a comparative study on SHSG holograms recorded on three different red sensitive emulsions: Agfa 8E75 HD, Slavich PFG-01 and BB-640 . The influence of the degree of hardening of the gelatin and the size and concentration of silver halide grains in the SHSG proccess is studied. And we will show that real high diffraction efficiencies can be obtained when using BB-640 and Slavich PFG-01 plates for recording phase transmission holograms (as high as 93% for PFG-01 and 90% for BB-640, allowing for reflections). Our investigations reveal that PFG-01 and BB-640 emulsions are not only a substitution to Agfa material, but may offer better results at a moment in which Agfa has stopped its production of holographic material.Una de las técnicas más interesantes para la obtención de elementos ópticos holográficos es la gelatina sensibilizada de haluro de plata (GSHP). Esta técnica combina la alta sensibilidad de las emulsiones fotográficas con los conocidos altos rendimientos en difracción y bajos niveles de scattering correspondientes a la gelatina dicromatada. En este trabajo se ha hecho un estudio comparativo sobre hologramas en gelatina sensibilizada de haluro de plata registrados en tres emulsiones diferentes sensibles al rojo: Agfa 8E75 HD, Slavich PFG-01 y BB-640. En dicho estudio se ha analizado la influencia del grado de endurecido de la gelatina y la concentración y el tamaño de los granos de haluro de plata en el procesado GHSP. Se obtuvieron rendimientos en difracción realmente altos cuando se utilizaron las placas BB-640 y Slavich PFG-01 para el registro de hologramas de fase por transmisión (tan altos como el 93% para las PFG-01 y el 90% para las BB-640, después de haber corregido los resultados teniendo en cuenta las reflexiones en las distintas superficies de separación de la placa). Nuestras investigaciones indican que las emulsiones BB-640 y Slavich PFG-01 pueden cubrir el vacío dejado por las placas Agfa 8E75 HD, e incluso pueden ofrecer mejores resultados en un momento en el cual Agfa ha dejado de fabricar material para aplicaciones en Holografía.
- Published
- 2000
6. Full polarimetric evaluation of the anamorphic transfer function for pixelated liquid crystal microdisplays
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Sánchez-Montes, Adriana R., Francés, Jorge, Martínez-Guardiola, Francisco J., Márquez, Andrés, Moya, Adrián, Mena, Emilio J., Calzado, Eva M., Neipp, Cristian, and Gallego, Sergi
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- 2025
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7. See-through display based on commercial photopolymer: Optimization and shrinkage effects
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Sirvent-Verdú, Joan Josep, Bravo, Juan Carlos, Colomina-Martínez, Jaume, Neipp, Cristian, Puerto, Daniel, Márquez, Andrés, and Gallego, Sergi
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- 2023
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8. Characterization and prediction of bending phenomena of holographic volume gratings based on deep learning
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Colomina Martínez, Jaume, primary, Francés, Jorge, additional, Bravo Francés, Juan Carlos, additional, Sirvent-Verdú, Joan Josep, additional, Pérez-Bernabeu, Andrés, additional, Neipp, Cristian, additional, and Alvarez, Mariela L., additional
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- 2024
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9. Novel PCA-Based Lower-Dimensional Remapping of the Solution Space for a Genetic Algorithm Optimization: Estimating the Director Distribution in LC-Based SLM Devices.
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Colomina-Martínez, Jaume, Sirvent-Verdú, Joan Josep, Bernabeu, Andrés P., Lloret, Tomás, Nieto-Rodríguez, Belén, Neipp, Cristian, Beléndez, Augusto, and Francés, Jorge
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NEMATIC liquid crystals ,DIMENSIONAL reduction algorithms ,SPATIAL light modulators ,LIQUID crystals ,ROBUST optimization - Abstract
This work introduces a novel computational approach based on Principal Component Analysis (PCA) for dimensionality reduction of the solution space in optimisation problems with known linear interdependencies among solution variables. By creating synthetic datasets with deliberately engineered properties and applying PCA, the solution space's remapping significantly reduces its dimensionality, leading to faster computation and more robust convergence in optimisation processes. We demonstrate this method by integrating it with a Genetic Algorithm (GA) for solving the optimal director distribution in liquid crystal (LC) devices, specifically addressing 2D and complex 3D spatial light modulator (SLM) structures such as twisted nematic liquid crystals (TN-LC) and parallel-aligned liquid crystal on silicon (PA-LCoS), respectively. The phase profiles obtained from the director vector distributions for horizontal and vertical high-frequency binary phase gratings closely match the theoretical values derived from minimising the traditional elastic Frank–Oseen functional via Euler–Lagrange equations. Beyond this specific application, our method offers a general framework for reducing computational complexity in optimisation problems by directly reducing the dimensionality of the solution space. This approach is applicable across various optimisation scenarios with well-known linear interdependencies among solution variables, enabling significant reductions in computational costs and improvements in robustness and convergence. [ABSTRACT FROM AUTHOR]
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- 2024
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10. Green Scalar Function Method for Analyzing Dielectric Media.
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Bravo, J. C., Colomina-Martínez, J., Sirvent-Verdú, J. J., Mena, E. J., Álvarez, M. L., Francés, J., Neipp, C., and Gallego, Sergi
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GREEN'S functions ,DIFFRACTIVE scattering ,BORN approximation ,MIE scattering ,APPROXIMATION theory ,ELECTROMAGNETIC wave scattering - Abstract
In this work we present a formalism based on scalar Green's functions to deal with electromagnetic scattering problems. Although the formulations of the Mie theory and Born approximations in terms of electromagnetic scattering are well known and relevant, they have certain disadvantages: complexity, computational time, few symmetries, etc. Therefore, the study with scalar Green's functions allows dealing with these problems with greater simplicity and efficiency. However, the information provided by the vector formulation is sacrificed. Nevertheless, different cases of electromagnetic scattering of dielectric media with different dimensions, geometries and refractive indices will be presented. Thus, we will be able to verify the capacity of this scalar method in predicting light-scattering problems. [ABSTRACT FROM AUTHOR]
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- 2024
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11. Eine seltene Differenzialdiagnose von Unterbauchschmerzen in der Kinder- und Jugendmedizin
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Müller, Sophie, Hillebrand, Georg, Wördehoff, Rosa, Heilenkötter, Uwe, and Neipp, Michael
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- 2022
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12. Holographic mirror-based approach in augmented reality glasses
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Iftekharuddin, Khan M., Awwal, Abdul A. S., Diaz-Ramirez, Victor Hugo, Márquez, Andrés, Márquez, A., García-Vázquez, J. C., Bravo, J. C., Francés, J., Neipp, C., Gallego, S., Ortuño, M., Ramírez, M. G., Pascual, I., and Beléndez, A.
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- 2024
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13. Elevated MUC5AC expression is associated with mismatch repair deficiency and proximal tumor location but not with cancer progression in colon cancer
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Rico, Sebastian Dwertmann, Höflmayer, Doris, Büscheck, Franziska, Dum, David, Luebke, Andreas M., Kluth, Martina, Hube-Magg, Claudia, Hinsch, Andrea, Möller-Koop, Christina, Perez, Daniel, Izbicki, Jakob R., Neipp, Michael, Mofid, Hamid, Lárusson, Hannes, Daniels, Thies, Isbert, Christoph, Coerper, Stephan, Ditterich, Daniel, Rupprecht, Holger, Goetz, Albert, Fraune, Christoph, Möller, Katharina, Menz, Anne, Bernreuther, Christian, Clauditz, Till S., Sauter, Guido, Uhlig, Ria, Wilczak, Waldemar, Simon, Ronald, Steurer, Stefan, Lebok, Patrick, Burandt, Eike, Krech, Till, and Marx, Andreas H.
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- 2021
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14. Manufacturing reflection holographic couplers for see-through applications recorded in photopolymers without prisms: An experimental validation
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Universidad de Alicante. Departamento de Física, Ingeniería de Sistemas y Teoría de la Señal, Universidad de Alicante. Instituto Universitario de Física Aplicada a las Ciencias y las Tecnologías, Sirvent-Verdú, Joan Josep, Bravo Francés, Juan Carlos, Colomina-Martínez, Jaume, Nájar, Guillem, Neipp, Cristian, Francés, Jorge, Gallego, Sergi, Beléndez, Augusto, Universidad de Alicante. Departamento de Física, Ingeniería de Sistemas y Teoría de la Señal, Universidad de Alicante. Instituto Universitario de Física Aplicada a las Ciencias y las Tecnologías, Sirvent-Verdú, Joan Josep, Bravo Francés, Juan Carlos, Colomina-Martínez, Jaume, Nájar, Guillem, Neipp, Cristian, Francés, Jorge, Gallego, Sergi, and Beléndez, Augusto
- Abstract
In the present work, the viability of a novel recording geometry to produce reflection holographic couplers is analyzed. Recalling the idea of previous works, photopolymers are used as the recording material because they have been proven to be well-suited for the intended see-through application: the capability to provide a virtual image without compromising the information about the surrounding environment. Moreover, holography fundamentals give us the proper background to examine the proposed design, where no prisms or microlenses arrays are used. Aiming to support the analysis, we provide experimental evidence that the produced reflection holographic gratings exhibit the correct properties to work as a coupler, where the sensitivity of the material and its properties are studied and examined.
- Published
- 2024
15. Estimation of characteristic parameters of holographic volume gratings based on machine learning
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Universidad de Alicante. Departamento de Física, Ingeniería de Sistemas y Teoría de la Señal, Universidad de Alicante. Instituto Universitario de Física Aplicada a las Ciencias y las Tecnologías, Colomina-Martínez, Jaume, Sirvent-Verdú, Joan Josep, Bravo Francés, Juan Carlos, Bernabeu, Andrés P., Alvarez, Mariela L., Francés, Jorge, Neipp, Cristian, Universidad de Alicante. Departamento de Física, Ingeniería de Sistemas y Teoría de la Señal, Universidad de Alicante. Instituto Universitario de Física Aplicada a las Ciencias y las Tecnologías, Colomina-Martínez, Jaume, Sirvent-Verdú, Joan Josep, Bravo Francés, Juan Carlos, Bernabeu, Andrés P., Alvarez, Mariela L., Francés, Jorge, and Neipp, Cristian
- Abstract
Estimating the actual parameters of real holographic volume gratings from diffraction efficiency measurements is challenging. The natural formation of the grating provides different phenomena, such as shrinkage, bending of the fringes, or non-homogeneous modulation as a function of the thickness, amongst other issues. This work proposes a deep learning Convolutional Neural Networks (CNNs) and Feedforward Neural Networks (FNNs) hybrid architecture capable of predicting the grating parameters from theoretical and experimental diffraction efficiency patterns. For the training set of this regression problem, Kogelnik’s Coupled Wave Theory simulated data has been employed. Our best model has been trained with an 8000-sized dataset of 80 points of diffraction efficiency patterns simulated from a range of values for the normalized grating wavelengths, index modulations, and optical depths. It achieves test losses under one per cent (mean absolute error) for predicting the normalized grating wavelengths, index modulations and optical depths.
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- 2024
16. Shrinkage effects in holographic couplers for see-through applications recorded in photopolymers
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Universidad de Alicante. Departamento de Física, Ingeniería de Sistemas y Teoría de la Señal, Universidad de Alicante. Instituto Universitario de Física Aplicada a las Ciencias y las Tecnologías, Sirvent-Verdú, Joan Josep, Bravo Francés, Juan Carlos, Piñol Galera, Carla, Neipp, Cristian, Gallego, Sergi, Beléndez, Augusto, Universidad de Alicante. Departamento de Física, Ingeniería de Sistemas y Teoría de la Señal, Universidad de Alicante. Instituto Universitario de Física Aplicada a las Ciencias y las Tecnologías, Sirvent-Verdú, Joan Josep, Bravo Francés, Juan Carlos, Piñol Galera, Carla, Neipp, Cristian, Gallego, Sergi, and Beléndez, Augusto
- Abstract
The see-through application of holographic optical elements (HOEs) has gained a lot of attention in the scientific literature in recent years. Regarding this kind of holograms recorded in photopolymers, the shrinkage plays an important role in the final properties of the display, as it may alter the Bragg angle. The present work is focused on the characterization of a HOE as a coupler in a waveguide combiner, recorded in holographic transmission geometry without prisms in the experimental set-up. From this point of view, it has been found that for specific geometries where the diffracted beam cannot be trapped a priori, a significant coupling effect exists: this variation in the diffracted energy and the propagation angle inside the glass can be used to measure the shrinkage of the photopolymer for this HOEs recording.
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- 2024
17. The PERMA+4 Positive Functioning at Work Scale: Spanish Adaptation and Validation.
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García-Selva, Adrián, Neipp, Marie-Carmen, Solanes-Puchol, Ángel, Martín-del-Río, Beatriz, and Donaldson, Stewart I.
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CONFIRMATORY factor analysis , *INDUSTRIAL psychology , *JOB performance , *TEST validity , *POSITIVE psychology - Abstract
Background: Donaldson & Donaldson (2021b) developed a scale to assess Positive Functioning at Work, adding four new blocks to strengthen the original PERMA framework in the workplace. The aim of the present study was to validate this scale in a Spanish sample. Method: 698 Spanish workers participated, 59% were women and 41% were men, 71.6% were employees and 71.2% belonged to the basic worker level. Results: Confirmatory Factor Analysis showed a good fit of the nine-factor model (χ²/df = 2.441; RMSEA = .056, 90% IC (.049, .063); SRMR =. 062; CFI = .926; TLI = .916), the bifactor model (χ²/df = 1.703; RMSEA = .044, 90% CI [.037, .050]; SRMR = .050; CFI = .959; TLI = .952) and the ESEM model (χ²/df = 1.736; RMSEA = .041, 90% CI [.033, .049]; SRMR = .017; CFI = .976; TLI = .942). The adapted scale also demonstrated good internal consistency, with a Cronbach's α of .90 for the scale, and evidence of discriminant, criterion, predictive, and incremental validity with other well-being and performance measures, as well as measurement invariance across educational levels. Conclusions: This scale provides a comprehensive measurement tool that can help in the design of workplace programs and interventions. [ABSTRACT FROM AUTHOR]
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- 2024
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18. Correction to: MMR Deficiency is Homogeneous in Pancreatic Carcinoma and Associated with High Density of Cd8-Positive Lymphocytes
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Fraune, Christoph, Burandt, Eike, Simon, Ronald, Hube-Magg, Claudia, Makrypidi-Fraune, Georgia, Kluth, Martina, Büscheck, Franziska, Höflmayer, Doris, Blessin, Niclas Ch., Mandelkow, Tim, Li, Wenchao, Perez, Daniel, Izbicki, Jakob R., Wilczak, Waldemar, Sauter, Guido, Schrader, Jörg, Neipp, Michael, Mofid, Hamid, Daniels, Thies, Isbert, Christoph, Clauditz, Till S., and Steurer, Stefan
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- 2022
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19. MMR Deficiency is Homogeneous in Pancreatic Carcinoma and Associated with High Density of Cd8-Positive Lymphocytes
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Fraune, Christoph, Burandt, Eike, Simon, Ronald, Hube-Magg, Claudia, Makrypidi-Fraune, Georgia, Kluth, Martina, Büscheck, Franziska, Höflmayer, Doris, Blessin, Niclas Ch., Mandelkow, Tim, Li, Wenchao, Perez, Daniel, Izbicki, Jakob R., Wilczak, Waldemar, Sauter, Guido, Schrader, Jörg, Neipp, Michael, Mofid, Hamid, Daniels, Thies, Isbert, Christoph, Clauditz, Till S., and Steurer, Stefan
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- 2020
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20. Quality of Life and Clinical Impairment in Spanish Adolescent Anorexia Nervosa Patients.
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Neipp, Marie-Carmen, Ruiz, Álvaro, Manchón, Javier, León-Zarceño, Eva, Quiles, María José, and Quiles, Yolanda
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ANOREXIA nervosa , *SPANIARDS , *QUALITY of life , *SOCIAL impact , *EATING disorders , *YOUNG women , *COMPULSIVE eating - Abstract
Eating disorders have serious physical, mental and social consequences that can affect the quality of life of the sufferer. This study aimed to evaluate the relationship between the severity of ED-related psychopathology and clinical impairment in adolescents with anorexia nervosa (AN) as well as their perception of health-related quality of life. Eighty-six Spanish young women with AN completed a set of questionnaires assessing eating disorder pathology, clinical impairment, and quality of life. The set included the following instruments: the Eating Disorder Examination Questionnaire, Clinical Impairment Assessment, Short Form-12 Item Health Survey, and the Eating Disorder-Specific Heath-Related Quality of Life instrument. Descriptive and regression analyses were applied to identify associations between variables. Higher scores on clinical impairment domains were associated with greater impairment of mental and physical health. Moreover, clinical impairment domains and concerns due to ED were related to a lower quality of life. In conclusion, adolescents with AN have a poor quality of life. Moreover, the findings suggest that the clinical features of impairment may serve as severity indicators of quality of life. [ABSTRACT FROM AUTHOR]
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- 2024
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21. Anxiety, self-esteem and body image in girls with precocious puberty
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Mercader-Yus, Esther, Neipp-López, M. Carmen, Gómez-Méndez, Pedro, Vargas-Torcal, Fernando, Gelves-Ospina, Melissa, Puerta-Morales, Laura, León-Jacobus, Alexandra, Cantillo-Pacheco, Kattia, and Mancera-Sarmiento, Malka
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- 2018
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22. Design and Characterization of 1,3-Dihydro-2H-benzo[d]azepin-2-ones as Rule-of-5 Compliant Bivalent BET Inhibitors
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Bamborough, Paul, primary, Chung, Chun-wa, additional, Goodwin, Nicole C., additional, Mitchell, Darren J., additional, Neipp, Christopher E., additional, Phillipou, Alex, additional, Preston, Alex, additional, Prinjha, Rab K., additional, Soden, Peter E., additional, Watson, Robert J., additional, and Demont, Emmanuel H., additional
- Published
- 2023
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23. The Global Outcomes of Solution-Focused Brief Therapy: A Revision.
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Neipp, Marie-Carmen and Beyebach, Mark
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BRIEF psychotherapy , *FAMILY psychotherapy , *PSYCHOLOGY information storage & retrieval systems , *ONLINE information services , *MEDICAL information storage & retrieval systems , *SYSTEMATIC reviews , *EVIDENCE-based medicine , *TREATMENT effectiveness , *MEDLINE , *DATA analysis software , *PSYCHOTHERAPY , *ERIC (Information retrieval system) - Abstract
Solution-focused Brief Therapy (SFBT) has generated outcome research worldwide and in a variety of intervention contexts. A systematic literature search yielded 251 published outcome studies on SFBT. SFBT was found superior to control groups or at post-test in almost nine out of every ten studies. Taking only 91 randomized controlled trials (RCTs) into account, SFBT was still found superior in seven out of every ten. Results varied slightly according to intervention type and format, manualization, and components of SFBT. They also varied more according to type of comparator and use of diagnostic criteria. These results widen the evidence base for SFBT. [ABSTRACT FROM AUTHOR]
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- 2024
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24. Auf Saurierjagd in Trossingen – Grabungen seit hundert Jahren
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Rainer R. Schoch and Volker Neipp
- Published
- 2022
25. Study of the conservation of different holograms sandwiched between glasses
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Sirvent-Verdú, Joan, primary, García-Vázquez, José Carlos, additional, Gallego Rico, Sergi, additional, Puerto, Daniel, additional, Neipp, Cristian, additional, Colomina-Martínez, Jaume, additional, Bravo, Juan Carlos, additional, Pascual, Inmaculada, additional, and Beléndez, Augusto, additional
- Published
- 2023
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26. Noise gratings in holographic waveguides recorded in photopolymers
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Universidad de Alicante. Departamento de Física, Ingeniería de Sistemas y Teoría de la Señal, Universidad de Alicante. Instituto Universitario de Física Aplicada a las Ciencias y las Tecnologías, Bravo Francés, Juan Carlos, Neipp, Cristian, Sirvent-Verdú, Joan Josep, Colomina-Martínez, Jaume, Márquez, Andrés, Francés, Jorge, Gallego, Sergi, Beléndez, Augusto, Universidad de Alicante. Departamento de Física, Ingeniería de Sistemas y Teoría de la Señal, Universidad de Alicante. Instituto Universitario de Física Aplicada a las Ciencias y las Tecnologías, Bravo Francés, Juan Carlos, Neipp, Cristian, Sirvent-Verdú, Joan Josep, Colomina-Martínez, Jaume, Márquez, Andrés, Francés, Jorge, Gallego, Sergi, and Beléndez, Augusto
- Abstract
It is a fact that augmented reality or virtual reality has burst into society with force: allowing the creation of programmed video games to be played with virtual reality glasses or the manufacture of glasses that act as mobile devices connected to the Internet ("Google glasses"). Augmented reality devices generally consist of a headset and a display system to show the user virtual information in addition to the real one. The systems used are the transparent optical screen and the mixed video screen. In this way, virtual images can be used that are shown to the user, mixed with reality or projected directly on the screen. On the other hand, the "glasses" have some advantages in relation to a direct viewing mobile screen, for example, hands-free and high privacy character. Among the different models of glasses proposed, transparent glasses are especially important for mobile use because they are safer and easier for the public to accept. However, combining high-quality images with clear visibility throughout the system remains a challenge. In this work, holographic waveguides will be manufactured in photopolymers and the experimental results will be contrasted with the numerical simulations carried out using the RCW models. An important fact that must be taken into account in the recording of the holographic waveguide is the possible recording of noise reflection gratings. In general, noise gratings in other devices extract a small amount of energy from the diffracted order, without any other spurious effects. However, in this particular device it will be shown that noise reflection gratings could create an unwanted afterimage. Since the reconstruction is performed at a different wavelength than the recording, the reflection noise grating may or may not be "visible" during the reconstruction, so it is possible to control the appearance of the gratings, for example, by controlling the thickness of the final waveguide. The gratings to performed the study were recorded
- Published
- 2023
27. Modelling photopolymer behavior as optical recording medium
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Universidad de Alicante. Departamento de Física, Ingeniería de Sistemas y Teoría de la Señal, Universidad de Alicante. Departamento de Óptica, Farmacología y Anatomía, Universidad de Alicante. Instituto Universitario de Física Aplicada a las Ciencias y las Tecnologías, Gallego, Sergi, Neipp, Cristian, Fernandez, Roberto, Bravo Francés, Juan Carlos, Sirvent-Verdú, Joan Josep, Bernabeu, Andrés P., Pascual, Inmaculada, Beléndez, Augusto, Universidad de Alicante. Departamento de Física, Ingeniería de Sistemas y Teoría de la Señal, Universidad de Alicante. Departamento de Óptica, Farmacología y Anatomía, Universidad de Alicante. Instituto Universitario de Física Aplicada a las Ciencias y las Tecnologías, Gallego, Sergi, Neipp, Cristian, Fernandez, Roberto, Bravo Francés, Juan Carlos, Sirvent-Verdú, Joan Josep, Bernabeu, Andrés P., Pascual, Inmaculada, and Beléndez, Augusto
- Abstract
Since photopolymers were first used as a holographic recording medium in the 1970s, one of the most important goals to be achieved was a quantitative understanding of their behaviour. In general, photopolymers are composed of one or more monomers, a binder and a dye that absorbs light in a certain region of the spectrum. The absorbed photons initiate polymerisation in the bright regions creating a concentration gradient compensated by the diffusion of chemical molecules described by Fick’s law. The first models to simulate the etching process in this type of materials were proposed in the early 1990s; they were very simple models where the authors assumed a harmonic in the monomer concentration, a constant rate of polymerisation and diffusion without direct influence of the refractive index of the monomer and the polymer. From this point on, improvements started to be made in the so-called “diffusion models”. One of the most important breakthroughs, proposed by John Sheridan’s research group in 2000, is the non-local behaviour of the photopolymer due to the finite size of the polymer chains. This phenomenon affects the limit of holographic recording resolution. Our research group at the University of Alicante (Spain) had the honour to collaborate with John Sheridan’s group developing new advances in the modelling of photopolymers as an optical recording medium, such as the threedimensional expansion of the models, and the explanation of surface variations or models to explain the recording of diffractive optical elements in this type of materials. In this papSer, we review this collaboration to improve diffusion models applied to photopolymers.
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- 2023
28. Study of the conservation of different holograms sandwiched between glasses
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Universidad de Alicante. Instituto Universitario de Física Aplicada a las Ciencias y las Tecnologías, Universidad de Alicante. Departamento de Física, Ingeniería de Sistemas y Teoría de la Señal, Universidad de Alicante. Departamento de Óptica, Farmacología y Anatomía, Sirvent-Verdú, Joan Josep, García-Vázquez, José Carlos, Gallego, Sergi, Puerto, Daniel, Neipp, Cristian, Colomina-Martínez, Jaume, Bravo Francés, Juan Carlos, Pascual, Inmaculada, Beléndez, Augusto, Universidad de Alicante. Instituto Universitario de Física Aplicada a las Ciencias y las Tecnologías, Universidad de Alicante. Departamento de Física, Ingeniería de Sistemas y Teoría de la Señal, Universidad de Alicante. Departamento de Óptica, Farmacología y Anatomía, Sirvent-Verdú, Joan Josep, García-Vázquez, José Carlos, Gallego, Sergi, Puerto, Daniel, Neipp, Cristian, Colomina-Martínez, Jaume, Bravo Francés, Juan Carlos, Pascual, Inmaculada, and Beléndez, Augusto
- Abstract
Photopolymers are designed and engineered with versatile applications including optics and photonics. Holography is one of the classical porpoises that use photopolymers as holographic recording materials. The success of these materials can be seen in the market with the photopolymer fabricated by Covestro. Some of these holographic applications require a long-time life of the holograms recorded in photopolymers. Nevertheless, initial tests of Covestro holograms show significant degradation after less than one year of exposure even after sealing and degradation occurs under solar light exposition. In this sense, it is important to perform deeper studies of the different possibilities for hologram conservation. Usually, the first step after recording is the material cure, with UV or visible light, to eliminate the residual dye and monomer. With this process high efficiency holograms can also be obtained. Afterwards, an index matching technique can be used to cover the material with a glass or it is possible the application of aerosol sealant. In this paper we analyze the introduction of holograms between two glasses linked by pressure, using Bayfol HX 200 from Covestro as the recording material. In order to characterize the process, four different spatial frequencies were tested, which were stored either by transmission or reflection schemes. The data of the reconstruction step has been measured before and after the encapsulation. In addition, multiple holograms have been superposed in the same glass, where we have found that shrinkage is more significant.
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- 2023
29. See-through display based on commercial photopolymer: Optimization and shrinkage effects
- Author
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Universidad de Alicante. Departamento de Física, Ingeniería de Sistemas y Teoría de la Señal, Universidad de Alicante. Instituto Universitario de Física Aplicada a las Ciencias y las Tecnologías, Sirvent-Verdú, Joan Josep, Bravo Francés, Juan Carlos, Colomina-Martínez, Jaume, Neipp, Cristian, Puerto, Daniel, Márquez, Andrés, Gallego, Sergi, Universidad de Alicante. Departamento de Física, Ingeniería de Sistemas y Teoría de la Señal, Universidad de Alicante. Instituto Universitario de Física Aplicada a las Ciencias y las Tecnologías, Sirvent-Verdú, Joan Josep, Bravo Francés, Juan Carlos, Colomina-Martínez, Jaume, Neipp, Cristian, Puerto, Daniel, Márquez, Andrés, and Gallego, Sergi
- Abstract
Nowadays augmented reality, 3D Image, mixed reality and see-through applications are very attractive technologies due to their great potential. Holographic optical elements can provide interesting solutions for injection and extraction of the image in the waveguides that are part of the see-through devices. We have developed a coupled waveguide system based on slanted transmission gratings recorded in manufactured photopolymers. In this work we optimize our schedule to a commercial photopolymer for this high demanded application. We demonstrate that high diffraction efficiencies can be obtained if we optimize the recording geometry, recording intensity and recording time for this material. In addition, we study the effects of shrinkage in our holographic system. In general shrinkage is an important drawback for holographic applications, nevertheless we demonstrate how shrinkage can help these systems open new possibilities. Lastly, we show how to significantly improve the quality of the guided image.
- Published
- 2023
30. General application of the genetic algorithm to the estimation of the Liquid Crystal Director in PA-LC devices
- Author
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Universidad de Alicante. Departamento de Física, Ingeniería de Sistemas y Teoría de la Señal, Universidad de Alicante. Departamento de Óptica, Farmacología y Anatomía, Universidad de Alicante. Instituto Universitario de Física Aplicada a las Ciencias y las Tecnologías, Colomina-Martínez, Jaume, Sirvent-Verdú, Joan Josep, Bernabeu, Andrés P., Lloret, Tomás, Nieto-Rodríguez, Belén, Neipp, Cristian, Beléndez, Augusto, Francés, Jorge, Universidad de Alicante. Departamento de Física, Ingeniería de Sistemas y Teoría de la Señal, Universidad de Alicante. Departamento de Óptica, Farmacología y Anatomía, Universidad de Alicante. Instituto Universitario de Física Aplicada a las Ciencias y las Tecnologías, Colomina-Martínez, Jaume, Sirvent-Verdú, Joan Josep, Bernabeu, Andrés P., Lloret, Tomás, Nieto-Rodríguez, Belén, Neipp, Cristian, Beléndez, Augusto, and Francés, Jorge
- Abstract
The study of liquid crystal (LC) director distribution is an important area of research in materials science and technology. Parallel-aligned liquid crystal (PA-LC) devices have been extensively studied due to their applications in liquid crystal displays, optical devices, and sensors. Estimating the LC director distribution is a critical step in designing and optimising PA-LC devices. This work shows the results derived from apply- ing novel optimisation techniques to estimate the liquid crystal (LC) director distribution in parallel-aligned liquid crystal (PA-LC) devices. Moreover, the genetic algorithm (GA) has been applied and compared with the minimisation of the Frank-Oseen free energy through the Euler-Lagrange equations. The GA is a stochastic optimisation technique that can effectively explore the search space and find the global optimum. Overall, this study’s results demonstrate the GA’s effectiveness in estimating the LC director distribution in PA-LC devices. This approach can improve the performance and design of liquid crystal displays, optical devices, and sensors. Furthermore, it can be extended to other fields where the optimisation of complex systems is required. Further research is needed to optimise the GA parameters and to explore its potential in other applications.
- Published
- 2023
31. Study of Image Formation in Volume Holography Using Numerical Simulation Techniques
- Author
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Neipp, Cristian, Francés, Jorge, Universidad de Alicante. Instituto Universitario de Física Aplicada a las Ciencias y las Tecnologías, Taleb, Soumia Imane, Neipp, Cristian, Francés, Jorge, Universidad de Alicante. Instituto Universitario de Física Aplicada a las Ciencias y las Tecnologías, and Taleb, Soumia Imane
- Abstract
This doctoral thesis presents the research carried out in developing and applying numerical methodologies to forming images by volume elements. The validity of the theoretical models used has been analysed by comparing the results obtained with the models generated with the results obtained using theoretical models that are well established in the scientific community. Furthermore, this knowledge has been applied to fabricating diffractive optical elements (DOEs) in PVA/AA photopolymers and the corresponding experimental validation with the developed theoretical models., En esta Tesis Doctoral se estudió la formación de imágenes en holografía de volumen. En primer lugar se desarrollaron diferentes modelos teóricos para simular el comportamiento de medios dieléctricos de volumen. En particular, se implementó un método no destructivo basado en la integral de Fresnel-Kirchhoff. Además del desarrollo de modelos teóricos que permitieron predecir el comportamiento de la radiación electromagnética en medios dieléctricos en esta Tesis se obtuvo también una contrapartida experimental. En ese sentido se fabricaron elementos ópticos difractivos mediante técnicas holográficas. En particular se fabricaron guías de onda holográficas con aplicaciones en la Realidad Aumentada.
- Published
- 2023
32. See-through display based on commercial photopolymer: Optimization and shrinkage effects
- Author
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Joan Josep Sirvent-Verdú, Juan Carlos Bravo, Jaume Colomina-Martínez, Cristian Neipp, Daniel Puerto, Andrés Márquez, Sergi Gallego, Universidad de Alicante. Departamento de Física, Ingeniería de Sistemas y Teoría de la Señal, Universidad de Alicante. Instituto Universitario de Física Aplicada a las Ciencias y las Tecnologías, and Holografía y Procesado Óptico
- Subjects
Optimization ,Multidisciplinary ,Shrinkage effects ,Photopolymers ,Holographic optical elements - Abstract
Nowadays augmented reality, 3D Image, mixed reality and see-through applications are very attractive technologies due to their great potential. Holographic optical elements can provide interesting solutions for injection and extraction of the image in the waveguides that are part of the see-through devices. We have developed a coupled waveguide system based on slanted transmission gratings recorded in manufactured photopolymers. In this work we optimize our schedule to a commercial photopolymer for this high demanded application. We demonstrate that high diffraction efficiencies can be obtained if we optimize the recording geometry, recording intensity and recording time for this material. In addition, we study the effects of shrinkage in our holographic system. In general shrinkage is an important drawback for holographic applications, nevertheless we demonstrate how shrinkage can help these systems open new possibilities. Lastly, we show how to significantly improve the quality of the guided image. The work was supported by the “Generalitat Valenciana” (Spain) project PROMETEO/2021/006 and by the ‘‘Universidad de Alicante’’ (UATALENTO18-10; ACIE-20-10). Generalitat Valenciana (Spain) (IDIFEDER/2021/014, cofunded by European Union through the FEDER Programme and “Ministerio de Ciencia e Innovación” of Spain (project PID2021-123124OB-I00).
- Published
- 2023
33. Polymerizable Materials for Diffractive Optical Elements Recording
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Fernández, Roberto Fernández, primary, Fuster, Víctor Navarro, additional, Guardiola, Francisco J. Martínez, additional, Rico, Sergi Gallego, additional, Ruiz, Andrés Márquez, additional, López, Cristian Neipp, additional, Villalobos, Inmaculada Pascual, additional, and Vázquez, Augusto Beléndez, additional
- Published
- 2018
- Full Text
- View/download PDF
34. See-Through Display Based on Commercial Photopolymer: Optimization and Shrinkage Effects
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Gallego, Sergi, primary, Sirvent-Verdú, Joan Josep, additional, Bravo, Juan Carlos, additional, Colomina-Martínez, Jaume, additional, Neipp, Cristian, additional, Puerto, Daniel, additional, and Márquez, Andrés, additional
- Published
- 2023
- Full Text
- View/download PDF
35. See-Through Display Based on Commercial Photopolymer: Optimization and Shrinkage Effects
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Sirvent-Verdú, Joan Josep, primary, Bravo, Juan Carlos, additional, Colomina-Martínez, Jaume, additional, Neipp, Cristian, additional, Puerto, Daniel, additional, Márquez, Andrés, additional, and Gallego, Sergi, additional
- Published
- 2023
- Full Text
- View/download PDF
36. Multi-GPU and multi-CPU accelerated FDTD scheme for vibroacoustic applications
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Francés, J., Otero, B., Bleda, S., Gallego, S., Neipp, C., Márquez, A., and Beléndez, A.
- Published
- 2015
- Full Text
- View/download PDF
37. Model of low spatial frequency diffractive elements recorded in photopolymers during and after recording
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Gallego, S., Márquez, A., Neipp, C., Fernández, R., Martínez Guardiola, J., Francés, J., Ortuño, M., Pascual, I., and Beléndez, A.
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- 2014
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- View/download PDF
38. Erfolgreiche Behandlung einer strahleninduzierten Rektum-Scheidenfistel mit modifiziertem vertikalem Rectus Abdominis-Lappen (VRAM)
- Author
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A Dittrich, G Kolios, A Formell, M Neipp, E-F Koller, and U Heilenkötter
- Published
- 2022
39. Eine seltene Differenzialdiagnose von Unterbauchschmerzen in der Kinder- und Jugendmedizin
- Author
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Sophie Müller, Georg Hillebrand, Rosa Wördehoff, Uwe Heilenkötter, and Michael Neipp
- Published
- 2022
40. Erfolgreiche Behandlung einer strahleninduzierten Rektum-Scheidenfistel mit modifiziertem vertikalem Rectus Abdominis-Lappen (VRAM)
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Dittrich, A, additional, Kolios, G, additional, Formell, A, additional, Neipp, M, additional, Koller, E-F, additional, and Heilenkötter, U, additional
- Published
- 2022
- Full Text
- View/download PDF
41. Capítulo 17 - La relación enfermera-paciente
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Leal-Costa, César, Neipp, M.ª Carmen, Tirado-González, Sonia, and Hofstadt, Carlos J. van-der
- Published
- 2023
- Full Text
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42. Mesothelin is Commonly Expressed in Pancreatic Adenocarcinoma but Unrelated to Cancer Aggressiveness
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Frank Jacobsen, Sören Weidemann, Michael Neipp, Ulf Nahrstedt, Jakob R. Izbicki, Till S. Clauditz, Eike Burandt, Christian Bernreuther, Ronald Simon, Daniel Perez, Till Krech, Hamid Mofid, Stefan Steurer, Thies Daniels, Andreas H. Marx, and Kristina Jansen
- Subjects
0301 basic medicine ,Cancer Research ,endocrine system diseases ,Adenocarcinoma ,GPI-Linked Proteins ,Metastasis ,03 medical and health sciences ,0302 clinical medicine ,Pancreatic cancer ,Biomarkers, Tumor ,Humans ,Medicine ,Mesothelin ,Tissue microarray ,biology ,business.industry ,Cancer ,General Medicine ,medicine.disease ,Immunohistochemistry ,Pancreatic Neoplasms ,030104 developmental biology ,Oncology ,Tissue Array Analysis ,030220 oncology & carcinogenesis ,Cancer research ,biology.protein ,Pancreatitis ,Cancer biomarkers ,business - Abstract
Data on Mesothelin expression in human normal and cancerous tissues is controversial. We employed immunohistochemistry on a tissue microarray from 599 pancreatic cancers and 12 large tissue sections of pancreatitis. Mesothelin expression was highest in pancreatic adenocarcinomas (89%) and adenocarcinomas of the ampulla Vateri (79%), infrequent in pancreatitis and absent in 6 acinus cell carcinomas and normal pancreas. Mesothelin expression was unrelated to pathological tumor stage, grade, metastasis, and tumor infiltrating CD8+ lymphocytes. In conclusion, pancreatic cancer may be ideally suited for putative anti-mesothelin therapies, and mesothelin may represent a suitable biomarker for pancreatic cancer diagnosis, especially on small biopsies.
- Published
- 2021
43. High density of cytotoxic T-lymphocytes is linked to tumoral PD-L1 expression regardless of the mismatch repair status in colorectal cancer
- Author
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Holger Rupprecht, Jakob R. Izbicki, Claudia Hube-Magg, Hannes Lárusson, Niclas C Blessin, Andreas M. Luebke, Guido Sauter, Sarah Minner, Katarzyna Zalewski, Hamid Mofid, Till S. Clauditz, Christian Bernreuther, Michael Neipp, Andrea Hinsch, Daniel Ditterich, Daniel Perez, Waldemar Wilczak, Stefan Steurer, Martina Kluth, Katharina Möller, Eike Burandt, Albert Goetz, Andreas H. Marx, Thies Daniels, Doris Höflmayer, Christoph Isbert, Franziska Büscheck, Ronald Simon, Till Krech, Ria Uhlig, and Stephan Coerper
- Subjects
Colorectal cancer ,DNA Mismatch Repair ,B7-H1 Antigen ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Immune system ,PD-L1 ,medicine ,Humans ,Cytotoxic T cell ,Radiology, Nuclear Medicine and imaging ,Lymph node ,Tissue microarray ,biology ,Tumor-infiltrating lymphocytes ,business.industry ,Hematology ,General Medicine ,medicine.disease ,medicine.anatomical_structure ,Lymphatic system ,Oncology ,030220 oncology & carcinogenesis ,Cancer research ,biology.protein ,Microsatellite Instability ,Colorectal Neoplasms ,business ,T-Lymphocytes, Cytotoxic - Abstract
BACKGROUND Immune checkpoint-inhibitors targeting the PD-1/PD-L1 system are FDA approved in microsatellite instable (MSI) or mismatch repair deficient (dMMR) colorectal cancer (CRC). PD-L1 expression is tightly linked to features connected to immune checkpoint inhibitor response, but studies on large subsets of cancers analyzing the correlation between different status of MSI/dMMR, tumor infiltrating lymphocytes and PD-L1 expression are still lacking. METHODS More than 1800 CRC were analyzed for PD-L1 by immunohistochemistry in a tissue microarray format. Data were compared to MMR, the number of intratumoral CD8+ cytotoxic T-cells, and adverse clinico-pathological parameters. Different cutoff levels for defining PD-L1 positivity in tumor cells (1%, 5%, 10%, and 50%) yielded comparable results. RESULTS At a cutoff level of 5%, PD-L1 positivity was seen in 5.1% of tumors. PD-L1 was more often positive in dMMR (18.6%) than in MMR proficient (pMMR) cancers (4.1%; p
- Published
- 2021
44. Parameter analysis for LCoS devices as a function of the voltage and wavelength
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Sánchez-Montes, Adriana R., Márquez, Andrés, Martínez Guardiola, Francisco Javier, Francés, Jorge, Neipp, Cristian, Calzado Estepa, Eva María, Puerto, Daniel, Pascual, Inmaculada, Gallego, Sergi, Beléndez, Augusto, Universidad de Alicante. Instituto Universitario de Física Aplicada a las Ciencias y las Tecnologías, Universidad de Alicante. Departamento de Física, Ingeniería de Sistemas y Teoría de la Señal, Universidad de Alicante. Departamento de Óptica, Farmacología y anatomía, and Holografía y Procesado Óptico
- Subjects
Física Aplicada ,Retardance ,Flicker ,Liquid-crystal-on-silicon spatial light modulators ,Óptica - Abstract
A model describing the parameter and wavelength dependencies not only of retardance, but also its flicker in liquid-crystal-on-silicon spatial light modulators (LCoS SLMs), is presented. We provide results for different digital addressing sequences producing different levels of flicker. Work funded by Generalitat Valenciana (Spain) (PROMETEO/2021/006, IDIFEDER/2021/014, cofunded by European Union through the FEDER Programme GV/2019/021); and Universidad de Alicante (Spain), projects GRE17-06 and UATALENTO 18-10.
- Published
- 2022
45. Photopolymers comparison for see-through applications
- Author
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Sirvent-Verdú, Joan Josep, Bravo Francés, Juan Carlos, Colomina-Martínez, Jaume, Neipp, Cristian, Puerto, Daniel, Gallego, Sergi, Beléndez, Augusto, Universidad de Alicante. Instituto Universitario de Física Aplicada a las Ciencias y las Tecnologías, Universidad de Alicante. Departamento de Física, Ingeniería de Sistemas y Teoría de la Señal, and Holografía y Procesado Óptico
- Subjects
See-through ,Física Aplicada ,Holography ,Photopolymers ,Augmented reality ,Óptica - Abstract
We have developed a coupled waveguide system based on slanted transmission gratings recorded in photopolymers. In this work we compare the behavior of four different photopolymers for this high demanded application. This work was supported by the “Generalitat Valenciana” of Spain (projects PROMETEO/2021/006 and IDIFEDER/2021/014, cofunded by European Union through the FEDER Programme) and by the Universidad de Alicante, Spain (UATALENTO18-10; ACIE-20-10).
- Published
- 2022
46. Mucin 5AC expression is common but unrelated to tumor progression in pancreatic adenocarcinoma
- Author
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Sebastian Dwertmann Rico, Franziska Büscheck, David Dum, Andreas M Luebke, Martina Kluth, Claudia Hube-Magg, Andrea Hinsch, Doris Höflmayer, Daniel Perez, Jakob R Izbicki, Michael Neipp, Hamid Mofid, Thies Daniels, Christoph Isbert, Christoph Fraune, Katharina Möller, Anne Menz, Christian Bernreuther, Patrick Lebok, Till Clauditz, Guido Sauter, Ria Uhlig, Waldemar Wilczak, Ronald Simon, Stefan Steurer, Eike Burandt, Andreas Marx, and Till Krech
- Subjects
Pharmacology ,Pancreatic Neoplasms ,Pancreatitis ,Carcinoma, Acinar Cell ,Immunology ,Immunology and Allergy ,Humans ,Microsatellite Instability ,Mucin 5AC - Abstract
Introduction: Mucin 5AC (MUC5AC) belongs to the family of secreted gel-forming mucins. It is physiologically expressed in some normal mucin producing epithelial cells but also in pancreatic, ovarian, and colon cancer cells. The role of MUC5AC expression in cancer is not fully understood. This study was designed to explore the role of MUC5AC for pancreatic cancer progression, its association to microsatellite instability, and its diagnostic utility. Methods: Mucin 5AC expression was studied immunohistochemically in a tissue microarray (TMA) from 532 pancreatic cancers, 61 cancers of the ampulla Vateri, six acinar cell carcinomas and 12 large sections of pancreatitis. Results: Mucin 5AC staining was interpretable in 476 of 599 (79%) arrayed cancers. Staining was completely absent in normal pancreas and pancreatitis, but frequent in pancreatic cancer. Membranous and cytoplasmic MUC5AC expression was most common in pancreatic adenocarcinomas (71% of 423), followed by carcinomas of the ampulla Vateri (43% of 47), and absent in six acinar cell carcinomas. Mucin 5AC expression was unrelated to tumor phenotype (tumor stage, tumor grade, lymph node, and distant metastasis), and microsatellite instability in ductal adenocarcinomas and carcinomas of the ampulla Vateri. Conclusion: Our study indicates that MUC5AC is an excellent biomarker for pancreatic cancer diagnosis, especially to support the sometimes-difficult diagnosis on small biopsies. Mucin 5AC expression is unrelated to pancreatic cancer aggressiveness.
- Published
- 2022
47. DOG1 overexpression is associated with mismatch repair deficiency and BRAF mutations but unrelated to cancer progression in colorectal cancer
- Author
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Kristina, Jansen, Martina, Kluth, Niclas C, Blessin, Claudia, Hube-Magg, Michael, Neipp, Hamid, Mofid, Hannes, Lárusson, Thies, Daniels, Christoph, Isbert, Stephan, Coerper, Daniel, Ditterich, Holger, Rupprecht, Albert, Goetz, Christian, Bernreuther, Guido, Sauter, Ria, Uhlig, Waldemar, Wilczak, Ronald, Simon, Stefan, Steurer, Eike, Burandt, Daniel, Perez, Jakob R, Izbicki, Frank, Jacobsen, Till S, Clauditz, Andreas H, Marx, and Till, Krech
- Subjects
Proto-Oncogene Proteins B-raf ,Proto-Oncogene Proteins p21(ras) ,Brain Neoplasms ,Neoplastic Syndromes, Hereditary ,Mutation ,Biomarkers, Tumor ,Humans ,Tumor Suppressor Protein p53 ,Colorectal Neoplasms ,Anoctamin-1 ,B7-H1 Antigen ,Neoplasm Proteins - Abstract
The transmembrane channel protein DOG1 (Discovered on GIST1) is normally expressed in the gastrointestinal interstitial cells of Cajal and also in gastrointestinal stroma tumors arising from these cells. However, there is also evidence for a relevant role of DOG1 expression in colorectal cancers. This study was undertaken to search for associations between DOG1 expression and colon cancer phenotype and key molecular alterations.A tissue microarray containing samples from more than 1,800 colorectal cancer patients was analyzed by immunohistochemistry.DOG1 immunostaining was detected in 503 (30.2%) of 1,666 analyzable colorectal cancers and considered weak in 360 (21.6%), moderate in 78 (4.7%), and strong in 65 (3.9%). Strong DOG1 immunostaining was associated with advanced pT stage (p=0.0367) and nodal metastases (p=0.0145) but these associations were not retained in subgroups of 1,135 mismatch repair proficient and 86 mismatch repair deficient tumors. DOG1 positivity was significantly linked to several molecular tumor features including mismatch repair deficiency (p=0.0034), BRAF mutations (p0.0001), nuclear p53 accumulation (p=0.0157), and PD-L1 expression (p=0.0199) but unrelated to KRAS mutations and the density of tumor infiltrating CD8 positive lymphocytes.Elevated DOG1 expression is frequent in colorectal cancer and significantly linked to important molecular alterations. However, DOG1 overexpression is largely unrelated to histopathological parameters of cancer aggressiveness and may thus not serve as a prognostic parameter for this tumor entity.
- Published
- 2022
48. Educational Software for Interference and Optical Diffraction Analysis in Fresnel and Fraunhofer Regions Based on MATLAB GUIs and the FDTD Method
- Author
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Frances, J., Perez-Molina, M., Bleda, S., Fernandez, E., Neipp, C., and Belendez, A.
- Abstract
Interference and diffraction of light are elementary topics in optics. The aim of the work presented here is to develop an accurate and cheap optical-system simulation software that provides a virtual laboratory for studying the effects of propagation in both time and space for the near- and far-field regions. In laboratory sessions, this software can let optical engineering undergraduates simulate many optical systems based on thin slits. The numerical method used is the finite-difference time-domain (FDTD) method that has been successfully applied in many engineering fields. Using this numerical method, the irradiance distribution can be successfully evaluated in different planes far from the simulation grid without degrading performance. In addition, an easy-to-use MATLAB GUI handles all the parameters of the FDTD simulation and computes theoretical values of irradiance for both the Fresnel and Fraunhofer regions. Therefore, by using this software, the student is able to analyze the behavior of the Fresnel and Fraunhofer expressions as a function of the distance. This distance is defined as the space between the slits plane and the plane that contains the virtual screen on which the irradiance pattern is represented. (Contains 1 table and 7 figures.)
- Published
- 2012
- Full Text
- View/download PDF
49. Complex Diffractive Optical Elements Stored in Photopolymers
- Author
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Roberto Fernández, Sergi Gallego, Andrés Márquez, Cristian Neipp, Eva María Calzado, Jorge Francés, Marta Morales-Vidal, and Augusto Beléndez
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holographic recording materials ,photopolymers ,diffractive elements ,optical axicons ,Organic chemistry ,QD241-441 - Abstract
We study the recording of complex diffractive elements, such as achromatic lenses, fork gratings or axicons. Using a 3-D diffusion model, previously validated, we are able to predict the behavior of photopolymer during recording. The experimental recording of these complex elements is possible thanks to a new generation spatial light modulator capable of generating periodic and aperiodic profiles. Both experimental and theoretical are analyzed and compared. The results show not only the good response of theoretical model to predict the behavior of the materials, but also the viability of photopolymers to store these kind of elements.
- Published
- 2019
- Full Text
- View/download PDF
50. Polarimetric analysis of cross-talk phenomena induced by the pixelation in PA-LCoS devices
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Francés, Jorge, primary, Márquez, Andrés, additional, Neipp, Cristian, additional, Puerto, Daniel, additional, Gallego, Sergi, additional, Pascual, Inmaculada, additional, and Beléndez, Augusto, additional
- Published
- 2022
- Full Text
- View/download PDF
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