1,196 results on '"Neidle, Stephen"'
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2. On the origins of the conflict between Rosalind Franklin and Maurice Wilkins
3. The mechanism of resistance in Escherichia coli to ridinilazole and other antibacterial head-to-head bis-benzimidazole compounds
4. Structural basis of water-mediated cis Watson–Crick/Hoogsteen base-pair formation in non-CpG methylation.
5. A Phenotypic Approach to the Discovery of Potent G-Quadruplex Targeted Drugs.
6. Folding of guanine quadruplex molecules -- funnel-like mechanism or kinetic partitioning? An overview from MD simulation studies
7. Comment on “Dark Nudges and Sludge in Big Alcohol: Behavioral Economics, Cognitive Biases, and Alcohol Industry Corporate Social Responsibility”
8. Principles of protein–DNA recognition
9. Methods for studying nucleic acid structure
10. The building blocks of DNA and RNA
11. RNA structures and their diversity
12. Principles of small molecule–DNA recognition
13. RNA binding proteins
14. Non-standard and higher-order DNA structures: DNA–DNA recognition
15. DNA structure as observed in fibres and crystals
16. On Water Arrangements in Right- and Left-Handed DNA Structures
17. Abstract A080: Target genes in pancreatic cancer cells of the pan-quadruplex clinical candidate compound QN-302 revealed by comparative transcriptome profiling
18. Abstract A081: The pan-quadruplex experimental drug QN-302 in pancreatic ductal adenocarcinoma (PDAC): Potential biomarkers for clinical studies
19. QN-302 demonstrates opposing effects between i-motif and G-quadruplex DNA structures in the promoter of the S100P gene
20. Preface
21. Challenges in developing small-molecule quadruplex therapeutics
22. A naphthalene diimide G-quadruplex ligand inhibits cell growth and down-regulates BCL-2 expression in an imatinib-resistant gastrointestinal cancer cell line
23. Targeting Quadruplex DNA: Chemistry to Clinical Trials
24. Abstract 4981: The potent quadruplex-binding compound QN-302 down-regulates the S100P gene in in vitro and in vivo models of pancreatic cancer: a potential therapeutic target and biomarker for PDAC
25. Abstract 390: A comparison of the activity of the quadruplex-targeting experimental drugs QN-302 and CX-5461 (pidnarulex) in wild-type and gemcitabine-resistant pancreatic cancer cell lines
26. A G-quadruplex-binding compound shows potent activity in human gemcitabine-resistant pancreatic cancer cells
27. Structure-Based Design of Selective and Potent G Quadruplex-Mediated Telomerase Inhibitors
28. A DNA-Porphyrin Minor-Groove Complex at Atomic Resolution: The Structural Consequences of Porphyrin Ruffling
29. Synergistic binding of actinomycin D and echinomycin to DNA mismatch sites and their combined anti-tumour effects
30. The Potent G-Quadruplex-Binding Compound QN-302 Downregulates S100P Gene Expression in Cells and in an In Vivo Model of Pancreatic Cancer
31. Molecular Modelling Approaches for Assessing Quadruplex–Small Molecule Interactions
32. Macrocyclic naphthalene diimides as G-quadruplex binders
33. Triazole-linked phenyl derivatives: Redox mechanisms and in situ electrochemical evaluation of interaction with dsDNA
34. Machine learning shows torsion angle preferences in left-handed and right-handed quadruplex DNAs
35. Abstract A079: The quadruplex-binding compound QN-302 in the MIA-PaCa2 pancreatic adenocarcinoma model shows no evidence of cardiac or neurological liabilities at therapeutic doses
36. Abstract B030: The quadruplex-binding compound QN-302 targets the S100P gene in PDAC
37. Structured Waters Mediate Small Molecule Binding to G-Quadruplex Nucleic Acids
38. G-Quadruplexes and Metal Ions
39. Staggered intercalation of DNA duplexes with base-pair modulation by two distinct drug molecules induces asymmetric backbone twisting and structure polymorphism
40. Small-molecule quadruplex-targeted drug discovery
41. G‐quadruplex‐binding small molecules ameliorate C9orf72 FTD/ALS pathology in vitro and in vivo
42. A new plant-derived antibacterial is an inhibitor of efflux pumps in Staphylococcus aureus
43. The influence of positional isomerism on G-quadruplex binding and anti-proliferative activity of tetra-substituted naphthalene diimide compounds
44. Abstract 4069: The potent quadruplex-binding compound SOP1812 shows anti-tumor activity in patient-derived in vivo models of pancreatic cancer
45. Abstract 4068: The potent quadruplex-binding compound SOP1812 shows potent anti-proliferative activity in a prostate cancer cell panel and anti-tumor activity in an in vivo model of metastatic prostate cancer
46. Abstract 2926: Structure-based design of quadruplex-binding small molecule compounds: The essential role of water molecules
47. Triazole–acridine conjugates: Redox mechanisms and in situ electrochemical evaluation of interaction with double-stranded DNA
48. Targeting pancreatic cancer with a G-quadruplex ligand
49. Structured Waters Mediate Small Molecule Binding to G-Quadruplex Nucleic Acids
50. Principles in the Design of DNA-Interactive Molecules
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