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486 results on '"Nei, M."'

1. Evolution of Vertebrate Immunoglobulin Variable Gene Segments

Author

Ota, T., Sitnikova, T., Nei, M., Compans, R. W., editor, Cooper, M., editor, Hogle, J. M., editor, Ito, Y., editor, Koprowski, H., editor, Melchers, F., editor, Oldstone, M., editor, Olsnes, S., editor, Potter, M., editor, Saedler, H., editor, Vogt, P. K., editor, Wagner, H., editor, Du Pasquier, Louis, editor, and Litman, Gary W., editor

Published
2000
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2. Serotonin receptor expression in hippocampus and temporal cortex of temporal lobe epilepsy patients by postictal generalized electroencephalographic suppression duration

Author

Leitner, DF, Devore, S, Laze, J, Friedman, D, Mills, JD, Liu, Y, Janitz, M, Anink, JJ, Baayen, JC, Idema, S, van Vliet, EA, Diehl, B, Scott, C, Thijs, R, Nei, M, Askenazi, M, Sivathamboo, S, O'Brien, T, Wisniewski, T, Thom, M, Aronica, E, Boldrini, M, Devinsky, O, Leitner, DF, Devore, S, Laze, J, Friedman, D, Mills, JD, Liu, Y, Janitz, M, Anink, JJ, Baayen, JC, Idema, S, van Vliet, EA, Diehl, B, Scott, C, Thijs, R, Nei, M, Askenazi, M, Sivathamboo, S, O'Brien, T, Wisniewski, T, Thom, M, Aronica, E, Boldrini, M, and Devinsky, O

Abstract

OBJECTIVE: Prolonged postictal generalized electroencephalographic suppression (PGES) is a potential biomarker for sudden unexpected death in epilepsy (SUDEP), which may be associated with dysfunctional autonomic responses and serotonin signaling. To better understand molecular mechanisms, PGES duration was correlated to 5HT1A and 5HT2A receptor protein expression and RNAseq from resected hippocampus and temporal cortex of temporal lobe epilepsy patients with seizures recorded in preoperative evaluation. METHODS: Analyses included 36 cases (age = 14-64 years, age at epilepsy onset = 0-51 years, epilepsy duration = 2-53 years, PGES duration = 0-93 s), with 13 cases in all hippocampal analyses. 5HT1A and 5HT2A protein was evaluated by Western blot and histologically in hippocampus (n = 16) and temporal cortex (n = 9). We correlated PGES duration to our previous RNAseq dataset for serotonin receptor expression and signaling pathways, as well as weighted gene correlation network analysis (WGCNA) to identify correlated gene clusters. RESULTS: In hippocampus, 5HT2A protein by Western blot positively correlated with PGES duration (p = .0024, R2 = .52), but 5HT1A did not (p = .87, R2 = .0020). In temporal cortex, 5HT1A and 5HT2A had lower expression and did not correlate with PGES duration. Histologically, PGES duration did not correlate with 5HT1A or 5HT2A expression in hippocampal CA4, dentate gyrus, or temporal cortex. RNAseq identified two serotonin receptors with expression that correlated with PGES duration in an exploratory analysis: HTR3B negatively correlated (p = .043, R2 = .26) and HTR4 positively correlated (p = .049, R2 = .25). WGCNA identified four modules correlated with PGES duration, including positive correlation with synaptic transcripts (p = .040, Pearson correlation r = .52), particularly potassium channels (KCNA4, KCNC4, KCNH1, KCNIP4, KCNJ3, KCNJ6, KCNK1). No modules were associated with serotonin receptor signaling. SIGNIFICANCE: Higher hippocamp

Published
2022

3. International case control study of Sudden Unexpected Death in Epilepsy (SUDEP)

Author

Sasikumar, S, Bergin, P, Beilharz, E, Langan, Y, Beghi, E, Cock, H, Donner, E, DSouza, W, Thomas, RH, Javier Rivas-Ruvalcaba, F, Rodriguez Leyva, I, Bosak, M, Dubenko, A, Voitiuk, A, Naboka, M, Gomez Equilaz, M, Ding, D, Fogarasi, A, Bognar, Z, Eliashiv, D, Mirsattari, S, Nei, M, Tan, HJ, O'Brien, T, Bebek, N, Lim, KS, Grant, A, Martinez-Juarez, IE, Pail, M, Franckx, H, Jansen, A, and Scragg, R

Published
2021

4. Assessing Molecular Phylogenies

Author

Edwards, A. W. F., Nei, M., Takezaki, N., Sitnikova, T., Hillis, David M., and Huelsenbeck, John P.

Published
1995

8. Origins and divergence times of mammalian class II MHC gene clusters

Author

Takahashi, K., Rooney, A.P., and Nei, M.

Subjects
Major histocompatibility complex -- Genetic aspects, Biological sciences
Abstract

Evolution of class II major histocompatibility complex genes is discussed. Their evolutionary history appears more complex than previously believed.

Published
2000

12. Let's stick together

Author

Nei, M.

Subjects
Heredity -- Research, Heredity -- Genetic aspects, Genetic research -- Analysis, Genomes -- Physiological aspects, Evolution -- Genetic aspects, Yeast -- Genetic aspects, Biological sciences
Abstract

The author discusses the studies on functionally interacting genes. The topics of interest indlude the relationship between gene clusters essential for viability, and the level of recombination within clusters in the baker's yeast genome.

Published
2003

13. Estimation of divergence times for a few mammalian and several primate species

Author

Nei, M. and Glazko, G.V.

Subjects
Mammals -- Genetic aspects, Mammals -- Research, Primates -- Genetic aspects, Primates -- Research, Genetic research, Biological sciences
Abstract

Statistical methods for estimating divergence times by using multiprotein gamma distances are discussed. Application of the methods to a dataset of 104 proteins from several vertebrate species indicated that the divergence times between humans and mice and between mice and rats are about 96 and 33 million years (MY) ago, respectively.

Published
2002

19. FDG PET-positive, MRI-negative Patients with Temporal Lobe Epilepsy: Etiology and Outcomes Compared to Patients with Hippocampal Sclerosis

Author

Khoury, C. LoPinto, Sperling, M., Skidmore, C., Nei, M., Zangaladze, A., Evans, J., Sharan, A., Mintzer, S., Khoury, C. LoPinto, Sperling, M., Skidmore, C., Nei, M., Zangaladze, A., Evans, J., Sharan, A., and Mintzer, S.

Abstract

FDG PET hypometabolism is important for surgical planning in patients with temporal lobe epilepsy (TLE), but its significance remains unclear in patients who do not have evidence of Hippocampal Sclerosis (HS) on MRI.

Published
2009

21. Mesial temporal lobe epilepsy with childhood febrile seizure.

Author

Asadi‐Pooya, A. A., Nei, M., Rostami, C., and Sperling, M. R.

Subjects
*TEMPORAL lobe epilepsy, *FEBRILE seizures, *DRUG resistance, *MEDICAL databases, *PEDIATRIC surgery, *HISTORY of medicine
Abstract

Objectives To evaluate the demographic and clinical manifestations of patients with mesial temporal sclerosis and temporal lobe epilepsy ( MTS- TLE) with childhood febrile seizure ( FS) and establishing the potential differences as compared to those without FS. We also investigated the surgery outcome in these two groups of patients. Materials and methods In this retrospective study, all patients with a clinical diagnosis of drug-resistant TLE due to mesial temporal sclerosis, who underwent epilepsy surgery at Jefferson Comprehensive Epilepsy Center, were recruited. Patients were prospectively registered in a database from 1986 through 2014. Postsurgical outcome was classified into two groups; seizure-free or relapsed. Clinical manifestations and outcome were compared between patients with MTS- TLE with FS and those without FS. Results Two hundred and sixty-two patients were eligible for this study. One hundred and seventy patients (64.9%) did not have FS in their childhood, while 92 patients (35.1%) reported experiencing FS in their childhood. Demographic and clinical characteristics of these two groups of patients were not different. Postoperative seizure outcome was not statistically different between these two groups of patients ( P = 0.19). Conclusions When MTS is the pathological substrate of TLE, clinical manifestations and response to surgical treatment of patients are very similar in patients with history of febrile seizure in their childhood compared to those without such an experience. In other words, when the subgroup of patients with MTS- TLE and drug-resistant seizures is examined history of childhood febrile seizure loses its value as a distinguishing factor in characteristics or predictive factor for surgery outcome. [ABSTRACT FROM AUTHOR]

Published
2017
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