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138 results on '"Nehme Salem"'

1. Feasibility of concrete mixtures containing coarse and/or fine recycled brick aggregates

Author

El-Mir Abdulkader, Nehme Salem, and Assaad Joseph

Subjects
brick, concrete aggregates, durability, mechanical properties, recycling, Engineering (General). Civil engineering (General), TA1-2040
Abstract

This paper assesses the feasibility of concrete mixtures containing high replacement rates of fine and/or coarse waste brick aggregates. Three mixture series prepared with different water-to-cement ratios are tested for workability, compressive strength, split tensile strength, modulus of elasticity, water permea-bility (by capillary or under pressure), and drying shrinkage. Test results showed that the concrete proper-ties remarkably degrade when the coarse natural aggregate fraction (i.e., retained on sieve No. 4) is fully replaced by recycled waste bricks, given their increased porosity that reduces the concrete density and weakens its skeleton. In contrast, the strength and durability remained almost unaltered when the fine natural aggregate fraction was replaced by 50 % recycled waste bricks, and considerably better than equivalent mixtures made using the same amount of recycled fine aggregates derived from hardened waste concrete.

Published
2022
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2. Laboratory testing of seepage in concrete

Author

Pap Miklós, Mahler András, and Nehme Salem Georges

Subjects
Environmental sciences, GE1-350
Abstract

Due to the construction of underground structures and hazardous waste storages, understanding and modelling of water flow through concrete has become a major topic for life-span analyses. The water retention curve (WRC) is an essential unsaturated soil function, which can be determined not only for soil samples, but also for other porous media. This paper deals with the determination of drying water retention curve for six different concrete mixtures that provide a substantial characteristic for the investigation and modelling of seepage through the pores of concrete. According to the complex pore system of the concrete, the bimodal function of van Genuchten (1980) and Fredlund and Xing (1994) models were used for curve fitting. The fitted curves were used to estimate the permeability function using Fredlund et. al (1994) model.

Published
2020
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3. A comprehensive investigation into the effect of temperature variation on the mechanical properties of sustainable concrete

Author

El Mir Abdulkader and Nehme Salem

Subjects
Engineering (General). Civil engineering (General), TA1-2040
Abstract

Minimizing the production energy and resources consumption are the key principle for engineering sustainability. In the case of concrete structures, this concept can be achieved by the use of materials in the most efficient way considering in the mix design the optimal mechanical and durability properties. The substitution of ordinary Portland cement for other supplementary cementitious materials is assessing the possibility of enhancing the sustainability and decreasing the environmental impact of concrete. Mass concrete is rich in cementitious materials which results in high temperature within the concrete, hence several hazards such as cracking or temperature differences between the interior and the surface of concrete could be prevented. An experimental study evaluated on several one cubic meter sized concrete elements in which during the primary phase of hydration, the temperature variation is recorded in several location offsets with respect to time. Thermal variations results are analyzed in accordance with the cement type, CO2 emission production of cement, compressive strength, water tightness, drying shrinkage and rapid chloride migration coefficient. The results indicate that slag cement CEM III/B 32.5, that incorporates highest amount of slag, ensured improved mechanical, thermal and durability properties in comparison with ordinary Portland cement CEM I 32.5.

Published
2017
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12. Betonszerkezetek károsodása lövedékbecsapódás hatására

Author

Lili Eszter Hlavicka-Laczák, Viktor Hlavička, György Károlyi, Ferenc Hajdú, Nehme Salem Georges, and István Vozsech

Subjects
General Materials Science
Abstract

A 2001. szeptember 11-i terrortámadás óta a kiemelt építményeket megnövekedett biztonsági elvárások mellett szükséges tervezni. Ez az előírás az újonnan épített nukleáris létesítményekre, köztük a Paks II. atomerőmű-beruházásra is vonatkozik. Ezen megnövekedett biztonsági igények meghatározzák, hogy a tervezett atomerőmű konténmentjének ellen kell állnia egy repülőgép-becsapódásnak is. Ilyen léptékű ütközés során igen sokféle extrém terhelés éri az építményt, kezdve a géptörzs felmorzsolódásától, a leszakadó hajtóművek behatolásán át, a kiömlő hajtóanyag berobbanásáig. Kevés ilyen skálájú kísérlet eredménye ismeretes, ezért a tervezés során nagy szerep jut egyrészt az elméleti megfontolásoknak és numerikus vizsgálatoknak, másrészt különféle tapasztalati képletek alkalmazásának. A számítások validálásához azonban szükség van megbízható mérési eredményekre. Sajnálatos, hogy a szakirodalomban fellelhető eredmények érvényességi köre nincs kellően körülhatárolva, ezért a Budapesti Műszaki és Gazdaságtudományi Egyetem és a Magyar Honvédség Modernizációs Intézet együttműködésében lőtéri tesztek segítségével vizsgáltuk a lövedék sebességének és a beton minőségének a hatását beton céltárgyak károsodására.

Published
2021
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13. Oral azacitidine preserves favorable level of fatigue and health-related quality of life for patients with acute myeloid leukemia in remission: results from the phase III, placebo-controlled QUAZAR AML-001 trial

Author

Roboz, Gail J., Döhner, Hartmut, Pocock, Christopher, Dombret, Hervé, Ravandi, Farhad, Jang, Jun Ho, Selleslag, Dominik, Mayer, Jiří, Martens, Uwe M., Liesveld, Jane, Bernal, Teresa, Wang, Ming Chung, Yu, Peiwen, Shi, Ling, Guo, Shien, La Torre, Ignazia, Skikne, Barry, Dong, Qian, Braverman, Julia, Nehme, Salem Abi, Beach, C. L., and Wei, Andrew H.

Subjects
Leukemia, Myeloid, Acute, Treatment Outcome, Remission Induction, Azacitidine, Quality of Life, Humans, Letters to the Editor, Fatigue
Published
2021

14. Repeatability of the rebound surface hardness of concrete with alteration of concrete parameters

Author

Mir, Abdulkader El and Nehme, Salem G.

Subjects
Concretes -- Mechanical properties -- Structure -- Analysis, Porosity -- Analysis, Nondestructive testing -- Usage -- Analysis, Compressive strength -- Analysis, Business, Construction and materials industries
Abstract

ABSTRACT Diagnostic of concrete structure properties is essential towards assessing the properties of the evaluated element. Since the Schmidt hammer is categorized as an economic and effective non-destructive testing tool, [...]

Published
2017
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17. A systematic literature review of disease burden and clinical efficacy for patients with relapsed or refractory acute myeloid leukemia

Author

Oliva, Esther Natalie, Ronnebaum, Sarah M, Zaidi, Omer, Patel, Dipen A, Nehme, Salem Abi, Chen, Clara, and Almeida, Antonio M

Subjects
Review Article
Abstract

Acute myeloid leukemia (AML) is a rapidly progressive hematological malignancy that is difficult to cure. The prognosis is poor and treatment options are limited in case of relapse. A comprehensive assessment of current disease burden and the clinical efficacy of non-intensive therapies in this population are lacking. We conducted two systematic literature reviews (SLRs). The first SLR (disease burden) included observational studies reporting the incidence and economic and humanistic burden of relapsed/refractory (RR) AML. The second SLR (clinical efficacy) included clinical trials (phase II or later) reporting remission rates (complete remission [CR] or CR with incomplete hematologic recovery [CRi]) and median overall survival (mOS) in patients with RR AML or patients with de novo AML who are ineligible for intensive chemotherapy. For both SLRs, MEDLINE(®)/Embase(®) were searched from January 1, 2008 to January 31, 2020. Clinical trial registries were also searched for the clinical efficacy SLR. After screening, two independent reviewers determined the eligibility for inclusion in the SLRs based on full-text articles. The disease burden SLR identified 130 observational studies. The median cumulative incidence of relapse was 29.4% after stem cell transplant and 46.8% after induction chemotherapy. Total per-patient-per-month costs were $28,148-$29,322; costs and health care resource use were typically higher for RR versus non-RR patients. Patients with RR AML had worse health-related quality of life (HRQoL) scores than patients with de novo AML across multiple instruments, and lower health utility values versus other AML health states (i.e. newly diagnosed, remission, consolidation, and maintenance therapy). The clinical efficacy SLR identified 50 trials (66 total trial arms). CR/CRi rates and mOS have remained relatively stable and low over the last 2 decades. Across all arms, the median rate of CR/CRi was 18.3% and mOS was 6.2 months. In conclusion, a substantial proportion of patients with AML will develop RR AML, which is associated with significant humanistic and economic burden. Existing treatments offer limited efficacy, highlighting the need for more effective non-intensive treatment options.

Published
2021

18. Oral azacitidine preserves favorable level of fatigue and health-related quality of life for patients with acute myeloid leukemia in remission: results from the phase 3, placebo-controlled QUAZAR AML-001 trial

Author

Roboz, Gail J., primary, Döhner, Hartmut, additional, Pocock, Christopher, additional, Dombret, Herve, additional, Ravandi, Farhad, additional, Jang, Jun Ho, additional, Selleslag, Dominik, additional, Mayer, Jiři, additional, Martens, Uwe M., additional, Liesveld, Jane, additional, Bernal, Teresa, additional, Wang, Ming Chung, additional, Yu, Peiwen, additional, Shi, Ling, additional, Guo, Shien, additional, La Torre, Ignazia, additional, Skikne, Barry, additional, Dong, Qian, additional, Braverman, Julia, additional, Nehme, Salem Abi, additional, Beach, C.L., additional, and Wei, Andrew H., additional

Published
2021
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19. Improved survival with enasidenib versus standard of care in relapsed/refractory acute myeloid leukemia associated with IDH2 mutations using historical data and propensity score matching analysis

Author

de Botton, Stéphane, primary, Brandwein, Joseph M., additional, Wei, Andrew H., additional, Pigneux, Arnaud, additional, Quesnel, Bruno, additional, Thomas, Xavier, additional, Legrand, Ollivier, additional, Recher, Christian, additional, Chantepie, Sylvain, additional, Hunault‐Berger, Mathilde, additional, Boissel, Nicolas, additional, Nehme, Salem A., additional, Frattini, Mark G., additional, Tosolini, Alessandra, additional, Marion‐Gallois, Roland, additional, Wang, Jixian J., additional, Cameron, Chris, additional, Siddiqui, Muhaimen, additional, Hutton, Brian, additional, Milkovich, Gary, additional, and Stein, Eytan M., additional

Published
2021
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24. Health-related quality of life (HRQoL) in the phase III QUAZAR-AML-001 trial of CC-486 as maintenance therapy for patients with acute myeloid leukemia (AML) in first remission following induction chemotherapy (IC).

Author

Roboz, Gail J., primary, Dohner, Hartmut, additional, Pocock, Christopher, additional, Dombret, Hervé, additional, Ravandi, Farhad, additional, Jang, Jun Ho, additional, Selleslag, Dominik, additional, Mayer, Jiri, additional, Martens, Uwe Marc, additional, Liesveld, Jane, additional, del Castillo, Teresa Bernal, additional, Wang, Ming-Chung, additional, La Torre, Ignazia, additional, Skikne, Barry, additional, Kumar, Keshava, additional, Dong, Qian, additional, Braverman, Julia, additional, Abi Nehme, Salem, additional, Beach, C. L., additional, and Wei, Andrew, additional

Published
2020
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27. Residual Modulus of Elasticity of Self-Compacting Concrete Incorporated Unprocessed Waste Fly Ash after Expose to the Elevated Temperature

Author

Abed, Mohammed, Nemes, Rita, and Nehme, Salem

Abstract

The present study experimentally investigated the impact of incorporating unprocessed waste fly ash (UWFA) on the residual mechanical properties of self-compacting concrete (SCC) after exposure to elevated temperature. Three mixtures of SCC have been produced by replacing the cement mass by 0%, 15% and 30% of UWFA. Generally, the fire resistance of SCC has been enhanced by replacing the cement up to 15% of UWFA, especially in case of residual modulus of elasticity which considers more sensitive than other mechanical properties at elevated temperature. However, a strong linear relationship has been observed between the residual flexural strength and modulus of elasticity, where both of them affected significantly by the cracks appearance and propagation as a result of elevated temperature. Sustainable products could be produced by incorporating unprocessed waste powder materials in the production of concrete, where the waste materials, CO2 emissions, and the energy needed for processing are reduced.

Published
2019
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30. Improved Overall Survival with Enasidenib Compared with Standard of Care Among Patients with Relapsed or Refractory Acute Myeloid Leukemia and IDH2 Mutations: A Propensity Score Matching Analysis Using Data from the AG221-C-001 Trial and Two Data Sources from France and Germany

Author

De Botton, Stephane, primary, Brandwein, Joseph M, additional, Stein, Eytan M., additional, Wei, Andrew H., additional, Weber, Daniela, additional, Pigneux, Arnaud, additional, Boissel, Nicolas, additional, Paschka, Peter, additional, Döhner, Konstanze, additional, Nehme, Salem Abi, additional, Frattini, Mark G., additional, Marion-Gallois, Roland, additional, Wang, Jixian (Jason), additional, Cameron, Chris, additional, Siddiqui, Muhaimen, additional, Qadeer, Rana A., additional, and Döhner, Hartmut, additional

Published
2019
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33. Numerical Evaluation of Bond Behavior of Ribbed Steel Bars or Seven-wire Strands Embedded in Lightweight Concrete.

Author

Abed, Mohammed A., Alkurdi, Zaher, Kheshfeh, Ahmad, Kovács, Tamás, and Nehme, Salem

Subjects
REINFORCING bars, STEEL bars, BEHAVIORAL assessment, CONCRETE beams, CONCRETE fatigue, LIGHTWEIGHT concrete, CRACKS in reinforced concrete
Abstract

The bond-slip relationship between concrete and steel is significant in evaluating the nonlinear behavior of reinforced concrete structures. The force transmitted by the bond in reinforced concrete structures was studied numerically in high-strength, lightweight concrete with ribbed reinforcing steel bar or seven-wire strand, using ATENA 3D software. The first part of the study was a validation of the model based on the actual results of standardized pull-out tests using the software. Subsequently, the bond behavior was studied, where a four-point static bending test was modeled based on the real bond-slip relationship of the pull-out test. It was deduced that the ATENA 3D software can simulate the experimental tests and provide meaningful results. In addition, inferred from the numerical modeling, the maximum crack width and the mid-span deflection of the reinforced concrete beam increased when the bond stress between the concrete and the reinforcing steel bars was decreased. When a high amount of reinforcement (two strands) was used, concrete failure occurred before the strands yielded. However, further increase of the bond stress also decreased the maximum crack width and mid-span deflection. The failure occurred due to the increase in the strand yielding point by using one strand as a reinforcement of the beam. [ABSTRACT FROM AUTHOR]

Published
2021
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