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3. Implications of leukocytosis following distal pancreatectomy splenectomy (DPS) and association with postoperative complications

Author

Jessica Y. Labib, Brendan P. Lovasik, Neha Lad, Julia Saltalamacchia, Shishir K. Maithel, Juan M. Sarmiento, Charles A. Staley, John F. Sweeney, and David A. Kooby

Subjects
Adult, Male, Leukocytosis, General Medicine, Middle Aged, Leukocyte Count, Pancreatectomy, Postoperative Complications, Oncology, Splenectomy, Humans, Surgery, Female, Aged, Retrospective Studies
Abstract

Early identification of complications after distal pancreatectomy splenectomy (DPS) poses challenges, as white blood cell count (WBC) is confounded by physiologic leukocytosis. We examined WBC patterns associated with complications after DPS.Clinicopathologic data were collected for patients who underwent DPS in our system from 2009 to 2016. We examined WBC, temperature, platelet count (PC), and ratios of these variables as potential early indicators of patients at risk of infections or major complications (MCs).348 patients met study inclusion, of whom 206 (59%) were women and the median patient age was 59 ± 15 years. Infectious and MC rates were 11% and 16%, respectively, with1% 30-day mortality. Postoperative WBC peaks were higher in patients with infections and MCs compared with no complication (23 vs. 17, p 0.0001). WBC peak timing occurred postoperative day (POD) 2-3 for uncomplicated cases while peaks occurred POD9 for patients with infections and MCs.These data define patterns of leukocytosis following DPS. Although differences in infection markers were identified for patients with and without complications, no obvious thresholds were identified. Clinical suspicion for complications after DPS remains our best tool for early identification.

Published
2022

4. Searching for VHE gamma-ray emission associated with IceCube neutrino alerts using FACT, H.E.S.S., MAGIC, and VERITAS

Author

Konstancja, Satalecka, Acciari, Victor A., Stefano, Ansoldi, Lucio Angelo Antonelli, Axel Arbet Engels, Manuel, Artero, Katsuaki, Asano, Dominik, Baack, Ana, Babic, Andr('(e))s, Baquero, Ulisses Barres de Almeida, Juan Abel Barrio, Ivana, Batkovi('(c)), Josefa Becerra Gonzalez, Wlodek, Bednarek, Lorenzo, Bellizzi, Elisa, Bernardini, Maria-Isabel, Bernardos, Alessio, Berti, Jürgen, Besenrieder, Wrijupan, Bhattacharyya, Ciro, Bigongiari, Adrian, Biland, Oscar, Blanch, Hendrik, Bökenkamp, Giacomo, Bonnoli, Zeljka, Bosnjak, Giovanni, Busetto, Roberto, Carosi, Giovanni, Ceribella, Matteo, Cerruti, Yating, Chai, Ashot, Chilingarian, Stefan, Cikota, Sidika Merve Colak, Eduardo, Colombo, Jose Luis Contreras, Juan, Cortina, Stefano, Covino, Giacomo D( extquotesingle)Amico, Valerio D( extquotesingle)Elia, Paolo Da Vela, Francesco, Dazzi, Alessandro De Angelis, Barbara De Lotto, Manuel, Delfino, Jordi, Delgado, Carlos Delgado Mendez, Davide, Depaoli, Federico Di Pierro, Leonardo Di Venere, Elia Do Souto Espi(~(n))eira, Dijana Dominis Prester, Alice, Donini, Daniela, Dorner, Michele, Doro, Dominik, Elsaesser, Vandad Fallah Ramazani, Alicia, Fattorini, Maria Victoria Fonseca, Lluis, Font, Christian, Fruck, Satoshi, Fukami, Yasushi, Fukazawa, Garc('(i))a L('(o))pez, Ramon J., Markus, Garczarczyk, Sargis, Gasparyan, Markus, Gaug, Giglietto, Nicola, Francesco, Giordano, Pawel, Gliwny, Nikola, Godinovic, David, Green, Jarred Gershon Green, Daniela, Hadasch, Alexander, Hahn, Lea, Heckmann, Javier, Herrera, John, Hoang, Dario, Hrupec, Moritz, Hütten, Tomohiro, Inada, Kazuma, Ishio, Yuki, Iwamura, Irene Jim('(e))nez Mart('(i))nez, Jenni, Jormanainen, L('(e))a, Jouvin, Marie, Karjalainen, Daniel, Kerszberg, Yukiho, Kobayashi, Hidetoshi, Kubo, Junko, Kushida, Alessandra, Lamastra, Damir, Lelas, Francesco, Leone, Elina, Lindfors, Lena, Linhoff, Saverio, Lombardi, Francesco, Longo, Ruben, Lopez-Coto, Marcos, L('(o))pez-Moya, Alicia, L('(o))pez-Oramas, Loporchio, Serena, Bernardo Machado de Oliveira Fraga, Camilla, Maggio, Pratik, Majumdar, Martin, Makariev, Manuela, Mallamaci, Galina, Maneva, Marina, Manganaro, Karl, Mannheim, Laura, Maraschi, Mos(`(e)), Mariotti, Manel, Martinez, Daniel, Mazin, Stefano, Menchiari, Simone, Mender, Sa( (s))a Mi('(c))anovi('(c)), Davide, Miceli, Tjark, Miener, Jose Miguel Miranda, Razmik, Mirzoyan, Edgar, Molina, Abelardo, Moralejo, Daniel, Morcuende, Victoria, Moreno, Elena, Moretti, Takeshi, Nakamori, Lara, Nava, Vitaly, Neustroev, Cosimo, Nigro, Kari, Nilsson, Kyoshi, Nishijima, Koji, Noda, Seiya, Nozaki, Yoshiki, Ohtani, Tomohiko, Oka, Jorge, Otero-Santos, Simona, Paiano, Michele, Palatiello, David, Paneque, Riccardo, Paoletti, Paredes, Josep M., Lovro, Pavleti('(c)), Pablo, Pe(~(n))il, Massimo, Persic, Marine, Pihet, Pier Giorgio Prada Moroni, Elisa, Prandini, Chaitanya, Priyadarshi, Ivica, Puljak, Wolfgang, Rhode, Marc, Rib('(o)), Javier, Rico, Chiara, Righi, Andrea, Rugliancich, Narek, Sahakyan, Takayuki, Saito, Shunsuke, Sakurai, Francesco Gabriele Saturni, Bernd, Schleicher, Kevin, Schmidt, Thomas, Schweizer, Julian, Sitarek, Iva, ( (S))nidari('(c)), Dorota, Sobczy('(n))ska, Alessia, Spolon, Antonio, Stamerra, Jelena Stri( (s))kovi('(c)), Derek, Strom, Marcel, Strzys, Yusuke, Suda, Tihomir, Suri('(c)), Mitsunari, Takahashi, Ryuji, Takeishi, Fabrizio, Tavecchio, Petar, Temnikov, Tomislav, Terzic, Masahiro, Teshima, Luca, Tosti, Stefano, Truzzi, Antonio, Tutone, Santiago, Ubach, Juliane van Scherpenberg, Gaia, Vanzo, Monica VAZQUEZ ACOSTA, Sofia, Ventura, Vassil, Verguilov, Carlo Francesco Vigorito, Vincenzo, Vitale, Ievgen, Vovk, Martin, Will, Carolin, Wunderlich, Tokonatsu, Yamamoto, Darko, Zari('(c)), Matteo, Balbo, Thomas, Bretz, Jens, Buss, Laura, Eisenberger, Dorothee, Hildebrand, Roman, Iotov, Adelina, Kalenski, Dominik, Neise, Maximilian, Noethe, Aleksander, Paravac, Vitalii, Sliusar, Roland, Walter, Rasha, Abbasi, Markus, Ackermann, Jenni, Adams, Juanan, Aguilar, Ahlers, M., Maryon, Ahrens, Cyril Martin Alispach, Antonio Augusto Alves Junior, Najia Moureen Binte Amin, Rui, An, Karen, Andeen, Tyler, Anderson, Gisela, Anton, Carlos, Arguelles, Yosuke, Ashida, Spencer, Axani, Xinhua, Bai, Aswathi Balagopal, V., Anastasia Maria Barbano, Barwick, S. W., Benjamin, Bastian, Vedant, Basu, Sebastian, Baur, Bay, R. C., Beatty, J. J., Becker, K. -H., Julia Becker Tjus, Chiara, Bellenghi, Segev, Benzvi, Berley, D., Besson, D. Z., Gary, Binder, Daniel, Bindig, Blaufuss, E., Summer, Blot, Matthias, Boddenberg, Federico, Bontempo, Jurgen, Borowka, Boser, S., Olga, Botner, Jakob, Bottcher, Etienne, Bourbeau, Federica, Bradascio, Braun, J., Stephanie, Bron, Jannes, Brostean-Kaiser, Sally-Ann, Browne, Alexander, Burgman, Ryan, Burley, Raffaela, Busse, Michael, Campana, Erin, Carnie-Bronca, Chujie, Chen, Dmitry, Chirkin, Koun, Choi, Bryanlee, Clark, Kenneth, Clark, Lew, Classen, Alan, Coleman, Gabriel, Collin, Conrad, J. M., Paul, Coppin, Pablo, Correa, Cowen, D. F., Cross, R., Christian, Dappen, Pranav, Dave, Catherine DE CLERCQ, James, Delaunay, Hans, Dembinski, Kunal, Deoskar, Sam De Ridder, Abhishek, Desai, Paolo, Desiati, Krijn de Vries, Gwenhaël de Wasseige, Meike De With, Tyce, Deyoung, Sukeerthi, Dharani, Alejandro, Diaz, Juan Carlos Diaz-Velez, Markus, Dittmer, Hrvoje, Dujmovic, Matt, Dunkman, Michael, Duvernois, Emily, Dvorak, Thomas, Ehrhardt, Philipp, Eller, Ralph, Engel, Hannah, Erpenbeck, John, Evans, Evenson, P. A., Kwok Lung Fan, Fazely, A. R., Sebastian, Fiedlschuster, Aaron, Fienberg, Kirill, Filimonov, Chad, Finley, Leander, Fischer, Derek, B Fox, Anna, Franckowiak, Elizabeth, Friedman, Alexander, Fritz, Philipp, Furst, Gaisser, T. K., Jay, Gallagher, Erik, Ganster, Alfonso, Garcia, Simone, Garrappa, Gerhardt, L., Ava, Ghadimi, Christian, Glaser, Theo, Glauch, Thorsten, Glusenkamp, Goldschmidt, A., Javier, Gonzalez, Sreetama, Goswami, Darren, Grant, Timoth('(e))e, Gr('(e))goire, Spencer, Griswold, Mehmet, Gunduz, Christoph, Günther, Christian, Haack, Allan, Hallgren, Halliday, R., Halve, L., Halzen, F., Martin Ha Minh, Kael, Hanson, John, Hardin, Harnisch, Alexander A., Andreas, Haungs, Simon, Hauser, Dustin, Hebecker, Helbing, K., Felix, Henningsen, Hettinger, Emma C., Stephanie, Hickford, Joshua, Hignight, Colton, Hill, Hill, G. C., Kara, Hoffman, Ruth, Hoffmann, Tobias, Hoinka, Benjamin, Hokanson-Fasig, Hoshina, K., Feifei, Huang, Matthias, Huber, Thomas, Huber, Klas, Hultqvist, Mirco, Hunnefeld, Raamis, Hussain, Seongjin, In, Nad(`(e))ge, Iovine, Aya, Ishihara, Matti, Jansson, George, Japaridze, Minjin, Jeong, Ben, Jones, Donghwa, Kang, Woosik, Kang, Xinyue, Kang, Alexander, Kappes, David, Kappesser, Timo, Karg, Martina, Karl, Karle, A., Katz, U., Kauer, M., Moritz, Kellermann, Kelley, J. L., Ali, Kheirandish, Ken( extquotesingle)ichi Kin, Thomas, Kintscher, Joanna, Kiryluk, Spencer, Klein, Ramesh, Koirala, Hermann, Kolanoski, Tomas, Kontrimas, Lutz, Kopke, Claudio, Kopper, Sandro, Kopper, Koskinen, D. J., Paras, Koundal, Michael, Kovacevich, Marek, Kowalski, Tetiana, Kozynets, Emma, Kun, Naoko, Kurahashi, Neha, Lad, Cristina Lagunas Gualda, Justin, Lanfranchi, Michael, J Larson, Frederik Hermann Lauber, Jeffrey, Lazar, Jiwoong, Lee, Kayla, Leonard, Agnieszka, Leszczy('(n))ska, Yijia, Li, Massimiliano, Lincetto, Qinrui, Liu, Maria, Liubarska, Elisa, Lohfink, Cristian Jesus Lozano Mariscal, Lu, Lu, Francesco, Lucarelli, Andrew, Ludwig, William, Luszczak, Yang, Lyu, Wing Yan Ma, James, Madsen, Kendall, Mahn, Yuya, Makino, Sarah, Mancina, Ioana Codrina Maris, Maruyama, Reina H., Mase, K., Thomas, Mcelroy, Frank, Mcnally, James Vincent Mead, Meagher, K., Andres, Medina, Maximilian, Meier, Stephan, Meighen-Berger, Jessie, Micallef, Daniela, Mockler, Teresa, Montaruli, Roger, Moore, Morse, R., Marjon, Moulai, Richard, Naab, Ryo, Nagai, Uwe, Naumann, Jannis, Necker, Le Viet Nguyen, Hans, Niederhausen, Mehr, Nisa, Sarah, Nowicki, Dave, Nygren, Anna Obertacke Pollmann, Marie, Oehler, Olivas, A., Erin O( extquotesingle)Sullivan, Hershal, Pandya, Daria, Pankova, Nahee, Park, Grant, Parker, Ek Narayan Paudel, Larissa, Paul, Carlos Perez de los Heros, Lilly, Peters, Saskia, Philippen, Damian, Pieloth, Sarah, Pieper, Martin, Pittermann, Pizzuto, A., Plum, M., Yuiry, Popovych, Alessio, Porcelli, Maria Prado Rodriguez, Buford Price, P., Brandom, Pries, Gerald, Przybylski, Christoph, Raab, Amirreza, Raissi, Mohamed, Rameez, Rawlins, K., Immacolata Carmen Rea, Abdul, Rehman, Ren('(e)), Reimann, Giovanni, Renzi, Elisa, Resconi, Simeon, Reusch, Mike, Richman, Benedikt, Riedel, Ella, Roberts, Sally, Robertson, Gerrit, Roellinghoff, Martin, Rongen, Carsten, Rott, Tim, Ruhe, Dirk, Ryckbosch, Devyn Rysewyk Cantu, Ibrahim, Safa, Julian, Saffer, Sebastian Sanchez Herrera, Alexander, Sandrock, Joakim, Sandroos, Marcos, Santander, Subir, Sarkar, Sourav, Sarkar, Maximilian Karl Scharf, Merlin, Schaufel, Harald, Schieler, Sebastian, Schindler, Schlunder, P., Torsten, Schmidt, Austin, Schneider, Judith, Schneider, Schröder, Frank G., Lisa Johanna Schumacher, Georg, Schwefer, Steve, Sclafani, Seckel, D., Surujhdeo, Seunarine, Ankur, Sharma, Shefali, Shefali, Manuel, Silva, Barbara, Skrzypek, Ben, Smithers, Robert, Snihur, Jan, Soedingrekso, Dennis, Soldin, Christian, Spannfellner, Glenn, Spiczak, Christian, Spiering, Juliana, Stachurska, Michael, Stamatikos, Stanev, T., Robert, Stein, Joeran, Stettner, Steuer, A., Stezelberger, T., Timo, Sturwald, Thomas, Stuttard, Sullivan, G. W., Taboada, I., Frederik, Tenholt, Samvel, Ter-Antonyan, Tilav, S., Franziska, Tischbein, Kirsten, Tollefson, Christoph, Tönnis, Simona, Toscano, Delia, Tosi, Alexander, Trettin, Maria, Tselengidou, Chunfai, Tung, Andrea, Turcati, Roxanne, Turcotte, Colin, Turley, Jean Pierre Twagirayezu, Bunheng, Ty, Martin Unland Elorrieta, Nora, Valtonen-Mattila, Justin, Vandenbroucke, Nick van Eijndhoven, David, Vannerom, Jakob van Santen, Stef, Verpoest, Matthias, Vraeghe, Walck, C., Timothyblake, Watson, Chris, Weaver, Philip, Weigel, Andreas, Weindl, Matthew, Weiss, Jan, Weldert, Chris, Wendt, Johannes, Werthebach, Mark, Weyrauch, Nathan, Whitehorn, Wiebusch, C. H., Dawn, Williams, Martin, Wolf, Kurt, Woschnagg, Gerrit, Wrede, Johan, Wulff, Xianwu, Xu, Yiqian, Xu, Juan Pablo Yanez, Yoshida, S., Shiqi, Yu, Tianlu, Yuan, Zelong, Zhang, Weidong, Jin, Hassan, Abdalla, Felix, Aharonian, Faical, Ait-Benkhali, Oguzhan, Anguener, Cornelia, Arcaro, Celine, Armand, Tom, Armstrong, Halim, Ashkar, Michael, Backes, Vardan, Baghmanyan, Victor Barbosa Martins, Anna, Barnacka, Monica, Barnard, Rowan, Batzofin, Yvonne, Becherini, David, Berge, Konrad, Bernlöhr, Baiyang, Bi, Markus, Boettcher, Catherine, Boisson, Julien, Bolmont, Mathieu de Bony, Mischa, Breuhaus, Robert, Brose, Francois, Brun, Tomasz, Bulik, Thomas, Bylund, Floriane, Cangemi, Sami, Caroff, Sabrina, Casanova, Jaqueline, Catalano, Pauline, Chambery, Tej Bahadur Chand, Andrew, Chen, Garret, Cotter, Malgorzata, Curlo, Jean Damascene Mbarubucyeye, Isak Delberth Davids, James, Davies, Justine, Devin, Arache, Djannati-Ataï, Anton, Dmytriiev, Axel, Donath, Victor, Doroshenko, Lente, Dreyer, Louis Du Plessis, Connor, Duffy, Kathrin, Egberts, Sabrina, Einecke, Gabriel, Emery, Jean-Pierre, Ernenwein, Steven, Fegan, Kirsty, Feijen, Armand, Fiasson, Gaëtan Fichet de Clairfontaine, Gerard, Fontaine, Lott, Frans, Matthias, Fuessling, Stefan, Funk, Stefano, Gabici, Yves, Gallant, Shahede, Ghafourizade, Gianluca, Giavitto, Luca, Giunti, Dorit, Glawion, Jean-Francois, Glicenstein, Marie-H('(e))l(`(e))ne, Grondin, Sumari, Hattingh, Maria, Haupt, German, Hermann, Jim, Hinton, Werner, Hofmann, Clemens, Hoischen, Tim, Holch, Markus, Holler, Dieter, Horns, Zhiqiu, Huang, David, Huber, Mario, Hörbe, Marek, Jamrozy, Felix, Jankowsky, Vikas, Joshi, Ira, Jung, Eli, Kasai, Krzysztof, Katarzynski, Ul(`(i)), Katz, Dmitry, Khangulyan, Bruno, Khelifi, Stefan, Klepser, Wlodek, Kluzniak, Nukri, Komin, Ruslan, Konno, Karl, Kosack, Dmitriy, Kostunin, Michael, Kreter, Ga( (s))per Kukec Mezek, Anu, Kundu, Giovanni, Lamanna, S('(e))bastien Le Stum, Anne, Lemiere, Marianne, Lemoine-Goumard, Jean-Philippe, Lenain, Fabian, Leuschner, Christelle, Levy, Thomas, Lohse, Anna, Luashvili, Iryna, Lypova, Jonathan, Mackey, Jhilik, Majumdar, Denys, Malyshev, Dmitry, Malyshev, Vincent, Marandon, Paolo, Marchegiani, Alexandre, Marcowith, Arnaud, Mares, Guillem Marti( extquotesingle)i-Devesa, Ramin, Marx, Gilles, Maurin, Pieter, Meintjes, Manuel, Meyer, Alison, Mitchell, Rafal, Moderski, Lars, Mohrmann, Alessandro, Montanari, Chris, Moore, Paul, Morris, Emmanuel, Moulin, Jacques, Muller, Thomas, Murach, Kaori, Nakashima, Mathieu Naurois (de), Amid, Nayerhoda, Hambeleleni, Ndiyavala, Jacek, Niemiec, Angel, Noel, Paul O( extquotesingle)Brien, Laenita Lorraine Oberholzer, Stefan, Ohm, Laura, Olivera-Nieto, Emma Ona-Wilhelmi (de), Michal, Ostrowski, Sebastian, Panny, Michael, Panter, Dan, Parsons, Giada, Peron, Santiago, Pita, Vincent, Poireau, Dmitry, Prokhorov, Heike, Prokoph, Gerd, Puehlhofer, Michael, Punch, Andreas, Quirrenbach, Patrick, Reichherzer, Anita, Reimer, Olaf, Reimer, Quentin, Remy, Matthieu, Renaud, Brian, Reville, Frank, Rieger, Carlo, Romoli, Gavin, Rowell, Bronislaw, Rudak, Hector Rueda Ricarte, Edna Ruiz Velasco, Vardan, Sahakian, Simon, Sailer, Heiko, Salzmann, David, Sanchez, Andrea, Santangelo, Manami, Sasaki, Johannes, Schaefer, Hester, Schutte, Ullrich, Schwanke, Fabian, Schüssler, Mohanraj, Senniappan, Albert, Seyffert, Shapopi, Jimmy N. S., Kleopas, Shiningayamwe, Rachel, Simoni, Atreyee, Sinha, Helene, Sol, Hugh, Spackman, Andreas, Specovius, Samuel Timothy Spencer, Marion, Spir-Jacob, Lukasz, Stawarz, Riaan, Steenkamp, Christian, Stegmann, Simon, Steinmassl, Constantin, Steppa, Lei, Sun, Tadayuki, Takahashi, Takaaki, Tanaka, Thomas, Tavernier, Andrew, Taylor, Regis, Terrier, Hannes, Thiersen, Charles, Thorpe-Morgan, Martin, Tluczykont, Lenka, Tomankova, Michelle, Tsirou, Naomi, Tsuji, Richard, Tuffs, Yasunobu, Uchiyama, Johann van der Walt, Christopher van Eldik, Carlo van Rensburg, Brian van Soelen, George, Vasileiadis, Johannes, Veh, Christo, Venter, Pascal, Vincent, Jacco, Vink, Völk, Heinrich J., Stefan, Wagner, Jason John Watson, Felix, Werner, Richard, White, Alicja, Wierzcholska, Yu Wun Wong, Hend, Yassin, Anke, Yusafzai, Michael, Zacharias, Roberta, Zanin, Davit, Zargaryan, Andrzej, Zdziarski, Andreas, Zech, Sylvia, Zhu, Andreas, Zmija, Samuel, Zouari, Natalia, Zywucka, The FACT Collaboration, The H.E.S.S. Collaboration, The IceCube Collaboration, The MAGIC Collaboration, The VERITAS Collaboration, and Współautorami artykułu są członkowie Magic Collaboration, IceCube Collaboration, FACT Collaboration, H.E.S.S. Collaboration, VERITAS Collaboration w liczbie 808

Subjects
Physics, High Energy Astrophysical Phenomena (astro-ph.HE), Point source, Astrophysics::High Energy Astrophysical Phenomena, Gamma ray, Astrophysics::Instrumentation and Methods for Astrophysics, FOS: Physical sciences, IACT, Astrophysics, law.invention, High Energy Physics - Experiment, Telescope, High Energy Physics - Experiment (hep-ex), law, HESS - Abteilung Hinton, ddc:530, High Energy Physics::Experiment, MAGIC (telescope), Neutrino, Blazar, Astrophysics - High Energy Astrophysical Phenomena, Cherenkov radiation
Abstract

The realtime follow-up of neutrino events is a promising approach to search for astrophysical neutrino sources. It has so far provided compelling evidence for a neutrino point source: the flaring gamma-ray blazar TXS 0506+056 observed in coincidence with the high-energy neutrino IceCube-170922A detected by IceCube. The detection of very-high-energy gamma rays (VHE, $\mathrm{E} > 100\,\mathrm{GeV}$) from this source helped establish the coincidence and constrained the modeling of the blazar emission at the time of the IceCube event. The four major imaging atmospheric Cherenkov telescope arrays (IACTs) - FACT, H.E.S.S., MAGIC, and VERITAS - operate an active follow-up program of target-of-opportunity observations of neutrino alerts sent by IceCube. This program has two main components. One are the observations of known gamma-ray sources around which a cluster of candidate neutrino events has been identified by IceCube (Gamma-ray Follow-Up, GFU). Second one is the follow-up of single high-energy neutrino candidate events of potential astrophysical origin such as IceCube-170922A. GFU has been recently upgraded by IceCube in collaboration with the IACT groups. We present here recent results from the IACT follow-up programs of IceCube neutrino alerts and a description of the upgraded IceCube GFU system., Presented at the 37th International Cosmic Ray Conference (ICRC 2021). See arXiv:2107.06966 for all IceCube contributions. See arXiv:2108.05257 for all H.E.S.S. contributions

Published
2022

5. Searching for Dark Matter from the Sun with the IceCube Detector

Author

Lisa Johanna Schumacher, Elisa Lohfink, Javier Gonzalez, Roxanne Turcotte, Catherine De Clercq, Michael DuVernois, Barbara Skrzypek, Larissa Paul, Naoko Kurahashi, Frank G. Schröder, Thomas McElroy, Erin O'Sullivan, S. Böser, Gerald Przybylski, Jakob van Santen, Shiqi Yu, Federica Bradascio, Alexander Burgman, Simeon Reusch, K. Meagher, Mehr Nisa, Benedikt Riedel, Stephanie Hickford, Delia Tosi, Sebastian Baur, Sebastian Fiedlschuster, Markus Ackermann, S. W. Barwick, Sreetama Goswami, Ken'ichi Kin, Ryan Burley, A. Steuer, Qinrui Liu, Martina Karl, Raamis Hussain, Aaron Fienberg, John Evans, Amirreza Raissi, U. Katz, Sally Robertson, Judith Schneider, Andres Medina, Donghwa Kang, Merlin Schaufel, Dawn Williams, Martin Pittermann, Chris Weaver, Stephanie Bron, K. Hoshina, Hrvoje Dujmovic, Jurgen Borowka, Benjamin Bastian, Anastasia Maria Barbano, Brian Clark, Sebastian Sanchez Herrera, Glenn Spiczak, Zelong Zhang, Michael Stamatikos, Jan Soedingrekso, P. Schlunder, John Hardin, Spencer Axani, Kael Hanson, Saskia Philippen, D. F. Cowen, A. Goldschmidt, Julia Becker Tjus, Markus Ahlers, Martin Unland Elorrieta, Shefali Shefali, C. Walck, Alfonso Garcia, Ankur Sharma, Jeffrey Lazar, Le Viet Nguyen, J. J. Beatty, Tianlu Yuan, Matthias Vraeghe, Torsten Schmidt, Abdul Rehman, Carsten Rott, Dave Nygren, Mohamed Rameez, Cyril Martin Alispach, Karen Andeen, Felix Henningsen, Tyler Anderson, Surujhdeo Seunarine, Thomas K. Gaisser, Timo Karg, Hermann Kolanoski, Carlos Arguelles, Lutz Kopke, Chiara Bellenghi, Thomas Kintscher, Maximilian Meier, Jessie Micallef, Juan Pablo Yanez, IceCube, Josh Peterson, Emma Kun, Paolo Desiati, Matthias Huber, Juanan Aguilar, Lenka Tomankova, Yosuke Ashida, A. R. Fazely, J. L. Kelley, Kenneth Clark, Aya Ishihara, Matthew Weiss, Yuiry Popovych, Kirill Filimonov, Pranav Dave, Maximilian Karl Scharf, Alejandro Diaz, Krijn de Vries, Stef Verpoest, Andreas Weindl, Jenni Adams, Xianwu Xu, Jay Gallagher, Minjin Jeong, K.-H. Becker, Ruth Hoffmann, Kwok Lung Fan, Alexander Fritz, Colin Turley, Erik Ganster, Najia Moureen Binte Amin, Uwe Naumann, T. Stanev, Yiqian Xu, Emma C. Hettinger, Matt Dunkman, Federico Bontempo, Nora Valtonen-Mattila, Marcos Santander, Francesco Lucarelli, Maria Liubarska, Ramesh Koirala, Dennis Soldin, Martin Ha Minh, Hans Dembinski, Erin Carnie-Bronca, Harald Schieler, K. Rawlins, Christian Glaser, Simona Toscano, Christian Spiering, Manuel Silva, Samvel Ter-Antonyan, Ben Jones, Alan Coleman, Gisela Anton, Maria Prado Rodriguez, Devyn Rysewyk Cantu, Gwenhaël de Wasseige, D. Z. Besson, Reina H. Maruyama, R. Halliday, Daniel Bindig, Georg Schwefer, L. Gerhardt, James Vincent Mead, Thomas Stuttard, Ryo Nagai, A. Olivas, E. Blaufuss, T. Stezelberger, Sarah Pieper, Markus Dittmer, Jannis Necker, Tetiana Kozynets, Neha Lad, Dirk Ryckbosch, Elizabeth Friedman, Chad Finley, Rasha Abbasi, Summer Blot, Matthias Boddenberg, Ibrahim Safa, Daria Pankova, Damian Pieloth, Ali Kheirandish, Sarah Mancina, Gerrit Roellinghoff, Stephan Meighen-Berger, Jannes Brostean-Kaiser, Kurt Woschnagg, Simon Hauser, Anna Franckowiak, Tobias Hoinka, Vedant Basu, James Madsen, Thorsten Glusenkamp, Massimiliano Lincetto, Lu Lu, Paul Evenson, S. Yoshida, I. Taboada, Dustin Hebecker, Nathan Whitehorn, Steve Sclafani, Klas Hultqvist, Joanna Kiryluk, Christoph Tönnis, Sally-Ann Browne, Brandom Pries, Mirco Hunnefeld, Marie Oehler, Segev BenZvi, Timothée Grégoire, Paras Koundal, Mike Richman, Colton Hill, Carlos Perez de los Heros, Gabriel Collin, Simone Garrappa, Dmitry Chirkin, Johan Wulff, Jan Weldert, Etienne Bourbeau, Spencer Klein, Julian Saffer, Chris Wendt, Sebastian Schindler, Michael Kovacevich, Pablo Correa, S. Tilav, Teresa Montaruli, Christoph Günther, Alexander Kappes, Michael Campana, Emily Dvorak, Cristian Jesus Lozano Mariscal, Kendall Mahn, K. Helbing, Elisa Bernardini, Tomas Kontrimas, Christian Dappen, Justin Vandenbroucke, Timothyblake Watson, Yijia Li, Sourav Sarkar, Benjamin Hokanson-Fasig, L. Halve, Philipp Eller, Christian Spannfellner, R. Morse, Frank McNally, Chunfai Tung, Olga Botner, Jakob Bottcher, Kara Hoffman, D. J. Koskinen, Antonio Augusto Alves Junior, Chujie Chen, Raffaela Busse, Anna Obertacke Pollmann, Yang Lyu, Joeran Stettner, Cristina Lagunas Gualda, Grant Parker, Philip Weigel, M. Plum, Mehmet Gunduz, Agnieszka Leszczyńska, R. C. Bay, Hershal Pandya, Martin Rongen, Wolfgang Rhode, Spencer Griswold, Maryon Ahrens, Joshua Hignight, Timo Sturwald, Frederik Tenholt, Wing Yan Ma, Feifei Huang, Hannah Erpenbeck, Konstancja Satalecka, Theo Glauch, Xinhua Bai, Austin Schneider, Abhishek Desai, Juan Carlos Diaz-Velez, Robert Stein, Maria Tselengidou, James DeLaunay, Marjon Moulai, Ava Ghadimi, Martin Wolf, Franziska Tischbein, Hans Niederhausen, Robert A. Cross, Frederik Hermann Lauber, Koun Choi, Andrew Ludwig, Justin Lanfranchi, Ben Smithers, Jean Pierre Twagirayezu, Jiwoong Lee, Rui An, Nahee Park, Darren Grant, Derek B Fox, Immacolata Carmen Rea, Sarah Nowicki, Andreas Haungs, Robert Snihur, C. H. Wiebusch, Kunal Deoskar, A. Karle, Ioana Codrina Maris, Sam De Ridder, Christoph Raab, Nadège Iovine, D. Berley, G. C. Hill, Bunheng Ty, Patrick Reichherzer, Ralph Engel, Moritz Kellermann, Giovanni Renzi, D. Seckel, Tyce DeYoung, George Japaridze, Roger Moore, Woosik Kang, Richard Naab, Marek Kowalski, Seongjin In, Elisa Resconi, Jan Conrad, K. Mase, Yuya Makino, Alessio Porcelli, Alexander A. Harnisch, Nick van Eijndhoven, Lew Classen, René Reimann, Leander Fischer, Thomas Ehrhardt, Christian Haack, Alexander Sandrock, Kirsten Tollefson, Kayla Leonard, Alexander Trettin, Sukeerthi Dharani, Francis Halzen, Lilly Peters, Juliana Stachurska, V Aswathi Balagopal, Gerrit Wrede, Johannes Werthebach, Thomas Huber, Ek Narayan Paudel, Michael J Larson, Allan Hallgren, Sandro Kopper, William Luszczak, M. Kauer, David Kappesser, Matti Jansson, P. Buford Price, Mark Weyrauch, Joakim Sandroos, Daniela Mockler, G. W. Sullivan, James E. Braun, Philipp Furst, Tim Ruhe, Paul Coppin, Andrea Turcati, Ella Roberts, Alex Pizzuto, Gary Binder, Xinyue Kang, Claudio Kopper, Subir Sarkar, and David Vannerom

Subjects
Physics, Dark matter, Detector, Astronomy
Published
2021
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7. An Assessment of the Academic Impact of Shock Society Members

Author

Neha Lad, Leonidas G. Koniaris, Daniel P. Milgrom, Teresa A. Zimmers, Brandon M. Wojcik, Teresa M. Bell, and Nakul P. Valsangkar

Subjects
Gerontology, Biomedical Research, education, MEDLINE, Scopus, Critical Care and Intensive Care Medicine, Article, 03 medical and health sciences, 0302 clinical medicine, Productivity, Publishing, Academic Medical Centers, business.industry, Shock, 030208 emergency & critical care medicine, United States, Shock (economics), 030220 oncology & carcinogenesis, Emergency Medicine, Regression Analysis, Professional association, business, Psychology, Trauma surgery, Career development
Abstract

Professional society membership enhances career development and productivity by offering opportunities for networking and learning about recent advances in the field. The quality and contribution of such societies can be measured in part through the academic productivity, career status, and funding success rates of their members. Here, using Scopus, NIH RePORTER, and departmental websites, we compare characteristics of the Shock Society membership to those of the top 55 NIH-funded American university and hospital-based departments of surgery. Shock Society members' mean number of publications, citations and H-indices were all significantly higher than those of non-members in surgery departments (P < 0.001). A higher percentage of members also have received funding from the NIH (42.5% vs. 18.5%, P < 0.001). Regression analysis indicated that members were more likely to have NIH funding compared with non-members (OR 1.46, 95% CI 1.12-1.916). Trauma surgeons belonging to the Shock Society had a higher number of publications and greater NIH funding than those who did not (130.4 vs. 42.7, P < 0.001; 40.4% vs. 8.5%, P < 0.001). Aggregate academic metrics from the Shock Society were superior to those of the Association for Academic Surgery and generally for the Society of University Surgeons as well. These data indicate that the Shock Society represents a highly academic and productive group of investigators. For surgery faculty, membership is associated with greater academic productivity and career advancement. While it is difficult to ascribe causation, certainly the Shock Society might positively influence careers for its members.

Published
2018
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8. Bone Pain and Muscle Weakness in Cancer Patients

Author

Teresa A. Zimmers, Daniel P. Milgrom, Neha Lad, and Leonidas G. Koniaris

Subjects
0301 basic medicine, Sarcopenia, medicine.medical_specialty, Cachexia, Endocrinology, Diabetes and Metabolism, Bone Neoplasms, Bioinformatics, Article, Bone and Bones, 03 medical and health sciences, Physical medicine and rehabilitation, Neoplasms, medicine, Humans, Bone pain, Wasting, Muscle Weakness, business.industry, Bone metastasis, Cancer, Muscle weakness, Cancer Pain, medicine.disease, 030104 developmental biology, Current management, Hypercalcemia, Bone Diseases, medicine.symptom, business
Abstract

In this article, we will discuss the current understanding of bone pain and muscle weakness in cancer patients. We will describe the underlying physiology and mechanisms of cancer-induced bone pain (CIBP) and cancer-induced muscle wasting (CIMW), as well as current methods of diagnosis and treatment. We will discuss future therapies and research directions to help patients with these problems. There are several pharmacologic therapies that are currently in preclinical and clinical testing that appear to be promising adjuncts to current CIBP and CIMW therapies. Such therapies include resiniferitoxin, which is a targeted inhibitor of noceciptive nerve fibers, and selective androgen receptor modulators, which show promise in increasing lean mass. CIBP and CIMW are significant causes of morbidity in affected patients. Current management is mostly palliative; however, targeted therapies are poised to revolutionize how these problems are treated.

Published
2017
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9. Vitrification of day 7 hatching blastocyst using hemistraw resulting in a full term delivery: a case study

Author

Neha Lad and Nitin Lad

Subjects
Pregnancy, business.industry, Hatching, medicine.medical_treatment, Embryo, medicine.disease, Cryopreservation, Andrology, medicine.anatomical_structure, embryonic structures, medicine, Gestation, Caesarean section, Blastocyst, business, reproductive and urinary physiology, Full Term
Abstract

This is probably the first report of a successful delivery following transfer of a vitrified-warmed day 7 slow growing hatching blastocyst using hemistraw-vitriplug as an embryo carrier system. Case Report: A 26 years old Indian woman underwent controlled ovarian stimulation using short antagonist protocol and on day 11 after hCG administration, sixteen mature oocytes obtained were fertilized by ICSI procedure. On day 5, after transfer of two expanded blastocysts, three supernumerary embryos were still in the expanding stages, therefore, continued to culture in vitro. On day 7, one of them grew to be a hatching blastocyst which was cryopreserved with caution by ultra-rapid vitrification using hemistraw (HS) as carrier system. After 5 months, the vitrified slow growing day 7 hatching blastocyst was warmed and transferred in a natural cycle resulting in successful pregnancy. The women delivered a healthy male baby weighing 2820 grams at 36 weeks of gestation by caesarean section with no obvious anomalies detected. This report concludes that a day 7 hatching blastocyst can be successfully vitrified using HS and have pregnancy potential after warming.

Published
2016
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10. Does the Organization of Plastic Surgery Units into Independent Departments Affect Academic Productivity?

Author

Scott N. Loewenstein, Leonidas G. Koniaris, Rajiv Sood, Stephen P. Duquette, Neha Lad, Nakul P. Valsangkar, Umakanth Avula, Juan Socas, and Roberto L. Flores

Subjects
medicine.medical_specialty, business.industry, Scopus, 030230 surgery, Affect (psychology), humanities, 03 medical and health sciences, Plastic surgery, 0302 clinical medicine, 030220 oncology & carcinogenesis, Family medicine, medicine, Surgery, business, Productivity, Health funding
Abstract

BACKGROUND There is an increased push for plastic surgery units in the United States to become independent departments administered autonomously rather than as divisions of a multispecialty surgery department. The purpose of this research was to determine whether there are any quantifiable differences in the academic performance of departments versus divisions. METHODS Using a list of the plastic surgery units affiliated with the American Council of Academic Plastic Surgeons, unit Web sites were queried for departmental status and to obtain a list of affiliated faculty. Academic productivity was then quantified using the SCOPUS database. National Institutes of Health funding was determined through the Research Portfolio Online Reporting Tools database. RESULTS Plastic surgery departments were comparable to divisions in academic productivity, evidenced by a similar number of publications per faculty (38.9 versus 38.7; p = 0.94), number of citations per faculty (692 versus 761; p = 0.64), H-indices (9.9 versus 9.9; p = 0.99), and National Institutes of Health grants (3.25 versus 2.84; p = 0.80), including RO1 grants (1.33 versus 0.84; p = 0.53). There was a trend for departments to have a more equitable male-to-female ratio (2.8 versus 4.1; p = 0.06), and departments trained a greater number of integrated plastic surgery residents (9.0 versus 5.28; p = 0.03). CONCLUSION This study demonstrates that the academic performance of independent plastic surgery departments is generally similar to divisions, but with nuanced distinctions.

Published
2017

11. Distal Cholangiocarcinoma

Author

Neha, Lad and David A, Kooby

Subjects
Cholangiocarcinoma, Bile Ducts, Intrahepatic, Bile Duct Neoplasms, Oncology, Humans, Surgery
Abstract

Distal cholangiocarcinoma is an uncommon malignancy and early diagnosis remains a challenge. More accurate diagnostic modalities for early-stage diagnosis are needed. Advances in medical therapy and neoadjuvant treatment may aid surgery and further improve postoperative outcomes. Margin-negative resection in conjunction with thorough nodal dissection is the strongest prognostic factor. Surgical resection coupled with adjuvant therapy provides the most favorable outcome. Future efforts should be aimed at reducing surgical complications and improving medical therapy, leading to overall improvement in perioperative and long-term outcomes for patients with this disorder.

Published
2014
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12. Abstract: Does the Organization of Plastic Surgery into Independent Departments Affect Academic Productivity?

Author

Nakul P. Valsangkar, Juan Socas, Leonidas G. Koniaris, Neha Lad, Umakanth Avula, Stephen P. Duquette, Rajiv Sood, and Roberto L. Flores

Subjects
Plastic surgery, medicine.medical_specialty, business.industry, Sunday, September 25, Emergency medicine, medicine, Surgery, Operations management, Research & Technology Session 2, Affect (psychology), business, Productivity
Published
2016

13. Abstract: What Factors Contribute to the Academic Productivity of Plastic Surgeons?

Author

Neha Lad, Roberto L. Flores, Nakul P. Valsangkar, Juan Socas, Stephen P. Duquette, Leonidas G. Koniaris, Umakanth Avula, and Rajiv Sood

Subjects
Monday, September 26, Medical education, business.industry, Medicine, Research & Technology Session 3, Surgery, business, Productivity, Agricultural economics
Published
2016

14. Percutaneous coronary intervention of the left main coronary artery in a patient with extrinsic compression caused by massive pulmonary artery enlargement

Author

Neha Lad, Stephen G. Ellis, Adil H. Al Kindi, Khaled F. Salhab, and Lars G. Svensson

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, Hypertension, Pulmonary, medicine.medical_treatment, Pulmonary Artery, Coronary Angiography, Severity of Illness Index, Extrinsic compression, Percutaneous Coronary Intervention, Internal medicine, medicine.artery, Humans, Medicine, Arterial Pressure, Vascular Patency, business.industry, Coronary Stenosis, Percutaneous coronary intervention, Middle Aged, Treatment Outcome, medicine.anatomical_structure, Pulmonary artery, Cardiology, Female, Stents, Surgery, Radiology, Tomography, X-Ray Computed, Cardiology and Cardiovascular Medicine, business, Dilatation, Pathologic, Artery
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