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1. Low-wage agricultural migrant workers in Apulian Ghettos, Italy: General health conditions assessment and HIV screening

Author

Di Gennaro, Francesco, Lattanzio, Rossana, Falanga, Carmine, Negri, Silvia, Papagni, Roberta, Novara, Roberta, Panico, Gianfranco Giorgio, Totaro, Valentina, Poliseno, Mariacristina, Bavaro, Davide Fiore, Raho, Lucia, Schiavone, Marcella, Laforgia, Nicole, Volpe, Alessandro, Laforgia, Renato, Lo Caputo, Sergio, Marotta, Claudia, Putoto, Giovanni, and Saracino, Annalisa

Published
2021

5. Blood Cell Count Derived Inflammation Indexes in Patients with Idiopathic Pulmonary Fibrosis

Author

Zinellu, Angelo, Paliogiannis, Panagiotis, Sotgiu, Elisabetta, Mellino, Sabrina, Mangoni, Arduino A., Zinellu, Elisabetta, and Negri, Silvia

Subjects
Inflammation -- Care and treatment, Pulmonary fibrosis -- Care and treatment, Lymphocytes, Medical colleges, Health
Abstract

Purpose Inflammation and immunity play a pivotal but yet unclear role in idiopathic pulmonary fibrosis (IPF), a chronic disorder characterized by progressive damage of lung parenchyma and severe loss of lung function despite optimal treatment. However, the pathophysiological and predictive role of combined blood cell count indexes of inflammation in IPF is uncertain. Methods Seventy-three patients with IPF and 62 healthy subjects matched for age, gender and smoking status were included in this cross-sectional study. Results We found significant differences in neutrophil to lymphocyte ratio (NLR), derived neutrophil to lymphocyte ratio (dNLR), monocyte to lymphocyte ratio (MLR), platelet to lymphocyte ratio (PLR), systemic inflammation response index (SIRI) and aggregate index of systemic inflammation (AISI) between IPF patients and healthy controls. In logistic regression, all combined blood inflammation indexes, barring PLR, were independently associated with the presence of IPF after adjusting for age, gender, body mass index and smoking status. Furthermore, significant associations between FVC% and NLR, LMR, SIRI and AISI, and between DLCO% and NLR, dNLR, LMR, SIRI and AISI, were observed. Conclusions In conclusion, our data indicate significant alterations of combined blood cell count indexes of inflammation in IPF., Author(s): Angelo Zinellu [sup.1], Panagiotis Paliogiannis [sup.2], Elisabetta Sotgiu [sup.1], Sabrina Mellino [sup.1], Arduino A. Mangoni [sup.4], Elisabetta Zinellu [sup.3], Silvia Negri [sup.2] [sup.3], Claudia Collu [sup.2] [sup.3], Gianfranco Pintus [...]

Published
2020
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7. Developing citizenship skills through cultural heritage and social networks

Author

Bosatelli, S, Fredella, C, Mosconi, G, DE MICHELE, C, Colombo Maria, E, Negri, S, Bosatelli Sofia, Fredella Claudia, Mosconi Germana, De Michele Cristina, Colombo Maria Elena, Negri Silvia, Bosatelli, S, Fredella, C, Mosconi, G, DE MICHELE, C, Colombo Maria, E, Negri, S, Bosatelli Sofia, Fredella Claudia, Mosconi Germana, De Michele Cristina, Colombo Maria Elena, and Negri Silvia

Abstract

Developing citizenship skills through cultural heritage and social networks The project, consistent with the orientation of the National Operational Programme, For School - Competences and Learning Environments (2014-2020) of the Ministry of Education, Universities and Research - aimed at form competent and responsible citizens in a modern, connected and interdependent society - is intended to: - developing a feeling of belonging to a broad, democratic and inclusive community, starting from an interdependence of political, economic, environmental, social and cultural dimensions, between local and global levels (Balibar, 2012); - in-depth exploration of citizenship education in an intercultural perspective, with a specific focus on heritage education (Bortolotti, Calidoni, Mascheroni, & Mattozzi 2008) in connection with a more aware use of digital tools and social networks. The project involved 5th-6th grade classes of the IC Alessandrini and IC Da Vinci in Cesano Boscone (Milan) to work on continuity between the different school levels; it has been monitored and evaluated using the participatory and “fourth generation” evaluation approach (Guba & Lincoln, 1989), aimed at enhancing the subjectivity of the participants, activating a reflexive comparison between them and providing useful evidence for the redesigning of similar actions. In this context we will focus on students’ activities analysis, carried out according to the qualitative method of content analysis (Krippendorff, 2004) with a coding system inspired by the constructivist approach of Grounded Theory (Charmaz, 2006). In a first phase, labels adhered to the text, following an analytical process of “naming” the data (Tarozzi, 2008, p. 84) and then grouped into categories representing the different identified units of meaning. A key aspect of the process has been intersubjectivity between the researchers who, coding the texts first separately then comparing each other, have been gradually redefining

Published
2023

8. Revisiting gendered representations of humility: an examination of sources from late medieval Italy

Author

Negri, Silvia and Negri, Silvia

Abstract

During the Middle Ages, gender-neutral representations of humility as a quality linked to spiritual love and voluntary service competed with representations according to gendered patterns, such as those related to the naked and dressed body in terms of its biological and social functions and its appearance. Moving from Dante's examples of humility in Purgatory, Canto X, this article focuses on representations of humility in textual and pictorial sources authored by women and men between the thirteenth and early fourteenth centuries in Italy. By showing the complexity of these representations, this article revisits and reconsiders one-sided historiographical narratives according to which humility in the Middle Ages was intrinsically, persistently and negatively related to feminine suppression and servility.

Published
2023

11. Epistemische Rivalitäten. Zum Umgang mit Sonderwissen an den Höfen des 14. Jahrhunderts.

Author

de Boer, Jan-Hendryk, Wallmeyer, Gion, Bubert, Marcel, Campopiano, Michele, Kopp, Vanina, Negri, Silvia, Neumann, Christian Alexander, Pachurka, Daniel, and Schuh, Maximilian

Subjects
EPISTEMICS, THEORY of self-knowledge, COURTS, POPES, EXPERTISE, FOURTEENTH century, LAITY, PRINCES
Abstract

Copyright of Historische Zeitschrift is the property of De Gruyter and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023
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12. The CATS Project

Author

Sbattella, Licia, Tedesco, Roberto, Li, Alberto Quattrini, Genovese, Elisabetta, Corradini, Matteo, Guaraldi, Giacomo, Garbo, Roberta, Mangiatordi, Andrea, Negri, Silvia, and Thaung, Khine Soe, editor

Published
2012
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23. Differentiation syndrome in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and anthracycline chemotherapy: characteristics, outcome, and prognostic factors

Author

Montesinos, Pau, Bergua, Juan M., Vellenga, Edo, Rayón, Chelo, Parody, Ricardo, de la Serna, Javier, León, Angel, Esteve, Jordi, Milone, Gustavo, Debén, Guillermo, Rivas, Concha, González, Marcos, Tormo, Mar, Díaz-Mediavilla, Joaquín, González, Jose D., Negri, Silvia, Amutio, Elena, Brunet, Salut, Lowenberg, Bob, and Sanz, Miguel A.

Published
2009
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25. Causes and prognostic factors of remission induction failure in patients with acute promyelocytic leukemia treated with all-trans retinoic acid and idarubicin

Author

de la Serna, Javier, Montesinos, Pau, Vellenga, Edo, Rayón, Chelo, Parody, Ricardo, León, Angel, Esteve, Jordi, Bergua, Juan M., Milone, Gustavo, Debén, Guillermo, Rivas, Concha, González, Marcos, Tormo, Mar, Díaz-Mediavilla, Joaquín, González, Jose D., Negri, Silvia, Amutio, Elena, Brunet, Salut, Lowenberg, Bob, and Sanz, Miguel A.

Published
2008
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26. Treatment of newly diagnosed acute promyelocytic leukemia (APL): a comparison of French-Belgian-Swiss and PETHEMA results

Author

Adès, Lionel, Sanz, Miguel A., Chevret, Sylvie, Montesinos, Pau, Chevallier, Patrice, Raffoux, Emmanuel, Vellenga, Edo, Guerci, Agnès, Pigneux, Arnaud, Huguet, Francoise, Rayon, Consuelo, Stoppa, Anne Marie, de la Serna, Javier, Cahn, Jean-Yves, Meyer-Monard, Sandrine, Pabst, Thomas, Thomas, Xavier, de Botton, Stéphane, Parody, Ricardo, Bergua, Juan, Lamy, Thierry, Vekhoff, Anne, Negri, Silvia, Ifrah, Norbert, Dombret, Hervé, Ferrant, Augustin, Bron, Dominique, Degos, Laurent, and Fenaux, Pierre

Published
2008
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27. HIV rapid test in a community setting as a strategy to improve access to HIV testing: data from a multicentre experience in Italy

Author

Falanga, Carmine, Marotta, Claudia, Negri, Silvia, Di Gennaro, Francesco, Fiore Bavaro, Davide, Poliseno, Mariacristina, Mazzucco, Walter, Laura MONNO, Saracino, Annalisa, Lo Caputo, Sergio, Falanga, Carmine, Marotta, Claudia, Negri, Silvia, Di Gennaro, Francesco, Fiore Bavaro, Davide, Poliseno, Mariacristina, Mazzucco, Walter, Monno, Laura, Saracino, Annalisa, and Lo Caputo, Sergio

Subjects
Adult, Male, Time Factors, Adolescent, health promotion, HIV infection, prevention intervention, HIV rapid test, AIDS Serodiagnosis, HIV Infections, Middle Aged, Settore MED/42 - Igiene Generale E Applicata, Health Services Accessibility, Young Adult, Italy, Prevalence, Humans, Female, Community Health Services, Retrospective Studies
Abstract

4,000 new HIV diagnoses and approximately 800 AIDS cases are still reported annually in Italy. Improving public awareness and bringing out HIV-undiagnosed individuals are keystones to progress towards the control of the HIV epidemic. For this purpose, the Open HIV TEST project was organized and delivered by the Italian NGO Anlaids, together with local infectious diseases specialists, in order to provide free access to HIV testing outside the healthcare setting. Between October 2017 and February 2019 six Open HIV TEST initiatives were delivered in six Italian cities (3 northern cities, 1 central and 2 southern cities). In all, 581 people were tested: the overall prevalence of HIV test reactivity was 0.7%. Participants were also asked about previous screenings and about their satisfaction with the initiative: previous HIV screening due to pregnancy or surgical procedures was reported mainly by participants in northern centres (p

Published
2019

28. Association Between Routine Blood Biomarkers and Clinical Phenotypes and Exacerbations in Chronic Obstructive Pulmonary Disease

Author

Núñez, Alexa, Marras, Viviana, Harlander, Matevz, Mekov, Evgeni, Esquinas, Cristina, Turel, Matjaz, Lestan, David, Petkov, Rosen, Yanev, Nikolay, Pirina, Pietro, Negri, Silvia, Miravitlles, Marc, and Barrecheguren, Miriam

Subjects
Blood cells, Phenotypes, COPD, Exacerbation, International Journal of Chronic Obstructive Pulmonary Disease, Biomarkers
Abstract

Alexa Nuñez,1,2,* Viviana Marras,3,* Matevz Harlander,4 Evgeni Mekov,5 Cristina Esquinas,1 Matjaz Turel,4 David Lestan,4 Rosen Petkov,5 Nikolay Yanev,5 Pietro Pirina,3 Silvia Negri,3 Marc Miravitlles,1,2,6 Miriam Barrecheguren1 1Pneumology Department, Hospital Universitari Vall d´Hebron/Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain; 2Medicine Department, Autonomous University of Barcelona (UAB), Barcelona, Spain; 3Respiratory Unit, AOU Sassari, Sassari, Italy; 4Department of Pulmonary Diseases, University Medical Centre Ljubljana, Ljubljana, Slovenia; 5Department of Pulmonary Diseases, Medical Faculty, Medical University of Sofia, Sofia, Bulgaria; 6CIBER de Enfermedades Respiratorias (CIBERES), Barcelona, Spain*These authors contributed equally to this workCorrespondence: Marc MiravitllesPneumology Department, Hospital Universitari Vall d´Hebron, P. Vall d’Hebron 119-129, Barcelona 08035, SpainTel +34 934893000Fax +34 93 274 82 08Email marcm@separ.esIntroduction: Chronic obstructive pulmonary disease (COPD) is associated with increased lung and systemic inflammation. We aimed to identify associations between easy-to-obtain blood biomarkers and the frequency and severity of exacerbations.Methods: Cross-sectional, multicentre study performed in four centres in Spain, Italy, Bulgaria, and Slovenia. Blood samples were obtained for blood cell count, C-reactive protein (CRP), alpha-1 antitrypsin (AAT) and fibrinogen analysis. The neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and eosinophil/basophil ratio (EBR) were calculated. Firstly, patients were divided into clinical phenotypes according to the Spanish guidelines of COPD, and secondly, patients were classified into 2 groups: non-exacerbators (≤ 1 ambulatory exacerbation in the previous year) and exacerbators (≥ 2 ambulatory exacerbations or 1 hospitalisation in the previous year). A multivariate stepwise logistic regression model was performed to identify laboratory parameters associated with exacerbators.Results: A total of 355 patients with a mean age 66 years (SD=8.9) were included, and 64% were male. The mean FEV1% (forced expiratory volume in the first second) was 55% (SD=20%), and the mean COPD Assessment Test (CAT) score was 15.6 (SD=7.9). One hundred ninety-six (55.2%) patients were classified in the non-exacerbator group, and 159 (44.8%) were exacerbators. Patients in the exacerbators group presented lower haemoglobin levels (p=0.019) and ERB (p= 0.023) but higher CRP levels (p=0.001). In the multivariate analysis, females, higher levels of CRP, lower FEV1% and low EBR were independently related to exacerbators.Conclusion: Female sex, having a more severe impairment of lung function, higher CRP levels and a lower EBR are associated with an exacerbator phenotype in COPD.Keywords: COPD, blood cells, biomarkers, exacerbation, phenotypes &nbsp

Published
2020

30. Association Between Routine Blood Biomarkers and Clinical Phenotypes and Exacerbations in Chronic Obstructive Pulmonary Disease

Author

Nuñez,Alexa, Marras,Viviana, Harlander,Matevz, Mekov,Evgeni, Esquinas,Cristina, Turel,Matjaz, Lestan,David, Petkov,Rosen, Yanev,Nikolay, Pirina,Pietro, Negri,Silvia, Miravitlles,Marc, Barrecheguren,Miriam, Nuñez,Alexa, Marras,Viviana, Harlander,Matevz, Mekov,Evgeni, Esquinas,Cristina, Turel,Matjaz, Lestan,David, Petkov,Rosen, Yanev,Nikolay, Pirina,Pietro, Negri,Silvia, Miravitlles,Marc, and Barrecheguren,Miriam

Abstract

Alexa Nuñez,1,2,* Viviana Marras,3,* Matevz Harlander,4 Evgeni Mekov,5 Cristina Esquinas,1 Matjaz Turel,4 David Lestan,4 Rosen Petkov,5 Nikolay Yanev,5 Pietro Pirina,3 Silvia Negri,3 Marc Miravitlles,1,2,6 Miriam Barrecheguren1 1Pneumology Department, Hospital Universitari Vall d´Hebron/Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain; 2Medicine Department, Autonomous University of Barcelona (UAB), Barcelona, Spain; 3Respiratory Unit, AOU Sassari, Sassari, Italy; 4Department of Pulmonary Diseases, University Medical Centre Ljubljana, Ljubljana, Slovenia; 5Department of Pulmonary Diseases, Medical Faculty, Medical University of Sofia, Sofia, Bulgaria; 6CIBER de Enfermedades Respiratorias (CIBERES), Barcelona, Spain*These authors contributed equally to this workCorrespondence: Marc MiravitllesPneumology Department, Hospital Universitari Vall d´Hebron, P. Vall d’Hebron 119-129, Barcelona 08035, SpainTel +34 934893000Fax +34 93 274 82 08Email marcm@separ.esIntroduction: Chronic obstructive pulmonary disease (COPD) is associated with increased lung and systemic inflammation. We aimed to identify associations between easy-to-obtain blood biomarkers and the frequency and severity of exacerbations.Methods: Cross-sectional, multicentre study performed in four centres in Spain, Italy, Bulgaria, and Slovenia. Blood samples were obtained for blood cell count, C-reactive protein (CRP), alpha-1 antitrypsin (AAT) and fibrinogen analysis. The neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR) and eosinophil/basophil ratio (EBR) were calculated. Firstly, patients were divided into clinical phenotypes according to the Spanish guidelines of COPD, and secondly, patients were classified into 2 groups: non-exacerbators (≤ 1 ambulatory exacerbation in the previous year) and exacerbators (≥ 2 ambulatory exacerbations or 1 hospitalisation in the previous year). A multivariate stepwise logistic regress

Published
2020

32. Effects of Pirfenidone and Nintedanib on Markers of Systemic Oxidative Stress and Inflammation in Patients with Idiopathic Pulmonary Fibrosis: A Preliminary Report

Author

Fois, Alessandro G., primary, Sotgiu, Elisabetta, additional, Scano, Valentina, additional, Negri, Silvia, additional, Mellino, Sabrina, additional, Zinellu, Elisabetta, additional, Pirina, Pietro, additional, Pintus, Gianfranco, additional, Carru, Ciriaco, additional, Mangoni, Arduino A., additional, and Zinellu, Angelo, additional

Published
2020
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38. Risk-adapted treatment of acute promyelocytic leukemia with all-trans-retinoic acid and anthracycline monochemotherapy: a multicenter study by the PETHEMA group

Author

Sanz, Miguel A., Martín, Guillermo, González, Marcos, León, Angel, Rayón, Chelo, Rivas, Concha, Colomer, Dolors, Amutio, Elena, Capote, Francisco J., Milone, Gustavo A., de la Serna, Javier, Román, José, Barragán, Eva, Bergua, Juan, Escoda, Lourdes, Parody, Ricardo, Negri, Silvia, Calasanz, María J., and Bolufer, Pascual

Published
2004
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40. Vêtir L'Humilité: De Bono Giamboni À Boccacce

Author

Negri, Silvia

Subjects
Humility, Representations of, Dante Alighieri, Bono Giamboni, Giovanni Boccaccio, Dressing Humility
Abstract

Representations of humility deserve far more scholarly attention and analysis than they have thus far received only by way of exception. This paper aims at partially filling this historiographical gap by considering topical accounts of humility in some Italian sources from the late 13th - early 14th centuries, especially in Bono Giamboni, Dante Alighieri and Giovanni Boccaccio. In particular, the paper focuses on the recurring theme of “dressing humility” in the works of the above mentioned authors with the aim to study and contextualize semantic shifts and usages of a literal and metaphorical juxtaposition – that of humility and dress – which already knew a long biblical and monastic tradition.

Published
2018
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41. Routine blood test biomarkers and their association with exacerbations in COPD

Author

Nuñez, Alexa, primary, Marras, Viviana, additional, Esquinas, Cristina, additional, Harlander, Matevz, additional, Turel, Matjaz, additional, Lestan, David, additional, Mekov, Evgeni, additional, Petkov, Rossen, additional, Pirina, Pietro, additional, Negri, Silvia, additional, Barrecheguren, Miriam, additional, and Miravitlles, Marc, additional

Published
2019
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46. Rezension von von Moos, P. Heiden im Himmel?: Geschichte einer Aporie zwischen Mittelalter und Früher Neuzeit. Mit kritischer Edition der Questio de salvatione Aristotelis des Lambertus de Monte (um 1500) v. Philipp Roelli. - (Philosophisch-historische Klasse der Heidelberger Akademie der Wissenschaften ; 54). - Heidelberg: Universitätsverlag Winter, 2014

Author

Negri, Silvia, University of Zurich, and Negri, Silvia

Subjects
10109 Institute of History, 900 History
Published
2015
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48. Frequency of Left Ventricular Hypertrophy in Non-Valvular Atrial Fibrillation

Author

Proietti M, Marra AM, Tassone EJ, De Vuono S, Corrao S, Gobbi P, Perticone F, Corazza GR, Basili S, Lip GY, Violi F, Raparelli V, ARAPACIS Study Investigators, GIS Group, Alessandri Cesare, Serviddio Gaetano, Fascetti Stefano, Serra Pietro, Palange Paolo, Greco Eleonora, Bruno Graziella, Averna Maurizio, Giammanco Antonina, Sposito Pietro, De Cristofaro Raimondo, De Gennaro Leonardo, Loria Paola, Pellegrini Elisa, Cominacini Luciano, Mozzini Chiara, Sprovieri Mario, Spagnuolo Vitaliano, Cerqua Giannantonio, Cerasola Giovanni, Mulé Giuseppe, Barbagallo Mario, Lo Sciuto Salvatore, Monteverde Alfredo, Saitta Antonino, Lo Gullo Alberto, Malatino Lorenzo, Cilia Chiara, Licata Giuseppe, Tuttolomondo Antonino, Conigliaro Roberta, Pinto Antonio, Di Raimondo Domenico, Signorelli Santo, Anzaldi Massimiliano, De Palma Daniela, Galderisi Maurizio, Cudemo Giuseppe, Galletti Ferruccio, Fazio Valeria, De Luca Nicola, Meccariello Alfonso, Caputo Dario, De Donato Maria Teresa, Iannuzi Arcangelo, Bresciani Alessandro, Giunta Riccardo, Cimini Claudia, Durante Mangoni Emanuele, Agrusta Federica, Iorio Federica, Adinolfi Luigi E, Sellitto Ausilia, Restivo Luciano, Bellis Paolo, Tirelli Paolo, Sacerdoti David, Pesce Paola, Vanni Dino, Iuliano Luigi, Ciacciarelli Marco, Pacelli Antonio, Palazzuoli Alberto, Cacciafesta Mauro, Gueli Nicola, Capeci William, Tarquinio Nicola, Pellegrini Francesco, Vincentelli Giovanni Maria, Ravallese Ferdinando, Santini Claudio, Letizia Claudio, Petramala Luigi, Zinnamosca Laura, Cilli Mirella, Savoriti Claudio, Falaschi Paolo, Martocchia Antonio, Stefanelli Manuela, Marigliano Vincenzo, Lo Iacono Cristina, Brusco Simona, Bertazzoni Giuliano, Attalla El Halabieh Elias, Paradiso Michele, Lizzi Eugenio Maria, Timmi Stefano, Battisti Paola, Cerci Sabina, Ciavolella Massimo, Di Veroli Claudio, Malci Francesco, De Ciocchis Anita, Abate Damiano, Castellino Pietro, Curto Irene, Vecchio Claudia, Mannarino Elmo, Pasqualini Leonella, Fattori Chiara, Pende Aldo, Denegri Andrea, Artom Nathan, Ricchio Roberto, Fimognari Filippo Luca, Alletto Maurizio, Messina Simona, Sesti Giorgio, Arturi Franco, Grembiale Alessandro, Perticone Francesco, Maio Raffaele, Scarpino Paola Elisa, Carullo Giuseppe, Sciacqua Angela, Frugiuele Pierluigi, Battaglia Giuseppe, Vidili Gianpaolo, Atzori Sebastiana, Delitala Giuseppe, Davì Giovanni, Angelucci Ermanno, Sestili Simona, Traisci Giancarlo, De Feudis Lucrezia, Di Michele Dario, Fava Alessandra, Balsano Clara, De Ciantis Pierpaolo, Desideri Giovambattista, Camerota Antonio, Migliacci Rino, Porciello Giovanni, Mezzetti Matteo, Gresele Paolo, Vedovati Cristina, Fierro Tiziana, Puccetti Luca, Scarpini Francesca, Bertolotti Marco, Mussi Chiara, Boddi Maria, Savino Andrea, Contri Silvia, Saller Alois, Fabris Fabrizio, Pesavento Raffaele, Filippi Lucia, Vedovetto Valentina, Puato Massimo, Treleani Martina, De Luca Elisabetta, De Zaiacomo Francesca, Giantin Valter, Semplicini Andrea, Minuz Pietro, Calabria Stefano, Romano Simone, Fantin Francesco, Manica Angela, Stockner Ingrid, Pattis Peter, Gutmann Bernhard, Catena Cristiana, Colussi GianLuca, Annoni Giorgio, Bruni Adriana Antonella, Castagna Alberto, Spinelli Diana, Corazza Gino Roberto, Miceli Emanuela, Padula, Schinco Giuseppina, Spreafico Sibilla, Secchi Beatrice, Vanoli Massimo, Casella Gianluca, Serra Maria Grazia, Longo Stefania, Antonaci Salvatore, Belfiore Anna, Ricci Lara, Ventrella Francesco, Iamele Luigi, Bianco Cesare, Santovito Donato, Cipollone Francesco, Nicolai Salvatore, Salvati Filippo, Rini Giovan Battista, Scozzari Francesca, Muiesan Maria Lorenza, Salvetti Massimo, Bazza Abramo, Picardi Antonio, De Vincentis Antonio, Cosio Paolo, Terzolo Massimo, Madaffari Bruno, Parasporo Bruno, Fenoglio Luigi, Bracco Christian, Melchio Remo, Gentili Tamira, Salvi Aldo, Nitti Cinzia, Falsetti L, Gabrielli Armando, Paglione Ivano, Capucci Alessandro, Brambatti Michela, Sparagna Armando, Tirotta Daniela, Andreozzi Paola, Ettorre Evaristo, Viscogliosi Giovanni, Rossi Fanelli Fillippo, Delfino Massimo, Glorioso Nicola, Melis Giada, Marras Gianfranca, Matta Michela, Sacco Andrea, Stellitano Elio, Scordo Anna, Russo Franco, Caruso Assunta Antonietta, Porreca Ettore, Santilli Francesca, Tana Marco, Ferri Claudio, Grassi Davide, Cheli Paola, Portincasa Piero, Muscianisi Giuseppe, Giordani Sara, Stanghellini Vincenzo, Sabbà Carlo, Suppressa Patrizia, Mancuso Gerardo, Bartone Mosè, Calipari Daniela, Arcidiacono Giuseppe, Bellanuova Ignazio, Ferraro Maria, Scalzo Antonio, Marigliano Giampietro, Cozzolino Domenico, Lampitella Antonio, Acri Vera, Galasso Domenico, Mazzei Francesca, Galasso Salvatore, Buratti Alberto, Porta Massimo, Brizzi Maria Felice, Fattorini Annalisa, Sampietro Francesca, D’Angelo Armando, Pala Marco, Fabbian Fabio, Manfredini Roberto, Moroni Carlo, Valente Lucia, Lopreiato Francesco, Parente Fernando, Moia Marco, Braham Simon, Rossi Marco, Pesce Margherita, Gentile Adelina, Catozzo Vania, Di Napoli Mariarosaria, Baciarello Giacinto, Rancan Elena, Ageno Walter, Guasti Luigina, Ciccaglioni Antonio, Negri Silvia, Polselli Marco, Abbate Rosanna, Marcucci Rossella, Cangemi Roberto, Pignataro Francesca Serena, Marco Proietti, Pastori Daniele, Ferro Domenico, Loffredo Lorenzo, Perri Ludovica, Catasca Elisa, Raparelli Valeria, Napoleone Laura, Talerico Giovanni, Calvieri Camilla, Vicario Tommasa, Russo Roberta, Saliola Mirella, Del Ben Maria, Angelico Francesco, Bucci Tommaso, Baratta Francesco, DATA AND SAFETY MONITORING BOARD (DSMB): Vestri Anna Rita, Farcomeni Alessio, Di Tanna Gianluca, STUDY COORDINATORS: Basili Stefania, Davi’ Giovanni, STEERING COMMITTEE OF ARAPACIS STUDY: Violi Francesco, Lip Gregory YH, Hiatt William R, Vestri Anna Rita, Mannucci Pier Mannuccio, Proietti Marco, Bazzini Cristina, Bianchi Paola Ilaria, Boari Benedetta, Buonauro Agostino, Buttà Carmelo, Buzzetti Elena, Carleo Pietro, Carrabba Maria Domenica, Castorani Luigi, Cecchetto Lara, Colombo Barbara Maria, De Giorgi Alfredo, De Vuono Stefano, Del Corso Lisette, Di Giosia Paolo, Falsetti Lorenzo, Forgione Alessandra, Hijazi Daniel, Lorusso Giusi, Marra Alberto Maria, Masala Maristella, Montebianco Abenavoli Ludovico, Murgia Giuseppe, Naccarato Paola, Pattoneri Paolo, Perego Francesca, Pinto Daniela, Pinna Miriam Pretti Vincenzo, Pucci Giacomo, Salinaro Francesco, Sirico Domenico, Tassone Eliezer Joseph, Torres Daniele, Vazzana Natale, Vecchio Claudia Rita, Vitale Francesco, Proietti M, Marra AM, Tassone EJ, De Vuono S, Corrao S, Gobbi P, Perticone F, Corazza GR, Basili S, Lip GY, Violi F, Raparelli V, ARAPACIS Study Investigators, GIS Group, Alessandri Cesare, Serviddio Gaetano, Fascetti Stefano, Serra Pietro, Palange Paolo, Greco Eleonora, Bruno Graziella, Averna Maurizio, Giammanco Antonina, Sposito Pietro, De Cristofaro Raimondo, De Gennaro Leonardo, Loria Paola, Pellegrini Elisa, Cominacini Luciano, Mozzini Chiara, Sprovieri Mario, Spagnuolo Vitaliano, Cerqua Giannantonio, Cerasola Giovanni, Mulé Giuseppe, Barbagallo Mario, Lo Sciuto Salvatore, Monteverde Alfredo, Saitta Antonino, Lo Gullo Alberto, Malatino Lorenzo, Cilia Chiara, Licata Giuseppe, Tuttolomondo Antonino, Conigliaro Roberta, Pinto Antonio, Di Raimondo Domenico, Signorelli Santo, Anzaldi Massimiliano, De Palma Daniela, Galderisi Maurizio, Cudemo Giuseppe, Galletti Ferruccio, Fazio Valeria, De Luca Nicola, Meccariello Alfonso, Caputo Dario, De Donato Maria Teresa, Iannuzi Arcangelo, Bresciani Alessandro, Giunta Riccardo, Cimini Claudia, Durante Mangoni Emanuele, Agrusta Federica, Iorio Federica, Adinolfi Luigi E, Sellitto Ausilia, Restivo Luciano, Bellis Paolo, Tirelli Paolo, Sacerdoti David, Pesce Paola, Vanni Dino, Iuliano Luigi, Ciacciarelli Marco, Pacelli Antonio, Palazzuoli Alberto, Cacciafesta Mauro, Gueli Nicola, Capeci William, Tarquinio Nicola, Pellegrini Francesco, Vincentelli Giovanni Maria, Ravallese Ferdinando, Santini Claudio, Letizia Claudio, Petramala Luigi, Zinnamosca Laura, Cilli Mirella, Savoriti Claudio, Falaschi Paolo, Martocchia Antonio, Stefanelli Manuela, Marigliano Vincenzo, Lo Iacono Cristina, Brusco Simona, Bertazzoni Giuliano, Attalla El Halabieh Elias, Paradiso Michele, Lizzi Eugenio Maria, Timmi Stefano, Battisti Paola, Cerci Sabina, Ciavolella Massimo, Di Veroli Claudio, Malci Francesco, De Ciocchis Anita, Abate Damiano, Castellino Pietro, Curto Irene, Vecchio Claudia, Mannarino Elmo, Pasqualini Leonella, Fattori Chiara, Pende Aldo, Denegri Andrea, Artom Nathan, Ricchio Roberto, Fimognari Filippo Luca, Alletto Maurizio, Messina Simona, Sesti Giorgio, Arturi Franco, Grembiale Alessandro, Perticone Francesco, Maio Raffaele, Scarpino Paola Elisa, Carullo Giuseppe, Sciacqua Angela, Frugiuele Pierluigi, Spagnuolo Vitaliano, Battaglia Giuseppe, Vidili Gianpaolo, Atzori Sebastiana, Delitala Giuseppe, Davì Giovanni, Angelucci Ermanno, Sestili Simona, Traisci Giancarlo, De Feudis Lucrezia, Di Michele Dario, Fava Alessandra, Balsano Clara, De Ciantis Pierpaolo, Desideri Giovambattista, Camerota Antonio, Migliacci Rino, Porciello Giovanni, Mezzetti Matteo, Gresele Paolo, Vedovati Cristina, Fierro Tiziana, Puccetti Luca, Scarpini Francesca, Bertolotti Marco, Mussi Chiara, Boddi Maria, Savino Andrea, Contri Silvia, Saller Alois, Fabris Fabrizio, Pesavento Raffaele, Filippi Lucia, Vedovetto Valentina, Puato Massimo, Fabris Fabrizio, Treleani Martina, De Luca Elisabetta, De Zaiacomo Francesca, Giantin Valter, Semplicini Andrea, Minuz Pietro, Calabria Stefano, Romano Simone, Fantin Francesco, Manica Angela, Stockner Ingrid, Pattis Peter, Gutmann Bernhard, Catena Cristiana, Colussi GianLuca, Annoni Giorgio, Bruni Adriana Antonella, Castagna Alberto, Spinelli Diana, Corazza Gino Roberto, Miceli Emanuela, Padula, Schinco Giuseppina, Spreafico Sibilla, Secchi Beatrice, Vanoli Massimo, Casella Gianluca, Serra Maria Grazia, Longo Stefania, Antonaci Salvatore, Belfiore Anna, Ricci Lara, Ventrella Francesco, Iamele Luigi, Bianco Cesare, Santovito Donato, Cipollone Francesco, Nicolai Salvatore, Salvati Filippo, Rini Giovan Battista, Scozzari Francesca, Muiesan Maria Lorenza, Salvetti Massimo, Bazza Abramo, Picardi Antonio, De Vincentis Antonio, Cosio Paolo, Terzolo Massimo, Madaffari Bruno, Parasporo Bruno, Fenoglio Luigi, Bracco Christian, Melchio Remo, Gentili Tamira, Salvi Aldo, Nitti Cinzia, Falsetti L, Gabrielli Armando, Paglione Ivano, Capucci Alessandro, Brambatti Michela, Sparagna Armando, Tirotta Daniela, Andreozzi Paola, Ettorre Evaristo, Viscogliosi Giovanni, Rossi Fanelli Fillippo, Delfino Massimo, Glorioso Nicola, Melis Giada, Marras Gianfranca, Matta Michela, Sacco Andrea, Stellitano Elio, Scordo Anna, Russo Franco, Caruso Assunta Antonietta, Porreca Ettore, Santilli Francesca, Tana Marco, Ferri Claudio, Grassi Davide, Cheli Paola, Portincasa Piero, Muscianisi Giuseppe, Giordani Sara, Stanghellini Vincenzo, Sabbà Carlo, Suppressa Patrizia, Mancuso Gerardo, Bartone Mosè, Calipari Daniela, Arcidiacono Giuseppe, Bellanuova Ignazio, Ferraro Maria, Scalzo Antonio, Marigliano Giampietro, Cozzolino Domenico, Lampitella Antonio, Acri Vera, Galasso Domenico, Mazzei Francesca, Galasso Salvatore, Buratti Alberto, Porta Massimo, Brizzi Maria Felice, Fattorini Annalisa, Sampietro Francesca, D’Angelo Armando, Pala Marco, Fabbian Fabio, Manfredini Roberto, Moroni Carlo, Valente Lucia, Lopreiato Francesco, Parente Fernando, Moia Marco, Braham Simon, Rossi Marco, Pesce Margherita, Gentile Adelina, Catozzo Vania, Di Napoli Mariarosaria, Baciarello Giacinto, Rancan Elena, Ageno Walter, Guasti Luigina, Ciccaglioni Antonio, Negri Silvia, Polselli Marco, Abbate Rosanna, Marcucci Rossella, Cangemi Roberto, Pignataro Francesca Serena, Marco Proietti, Pastori Daniele, Ferro Domenico, Loffredo Lorenzo, Perri Ludovica, Catasca Elisa, Raparelli Valeria, Napoleone Laura, Talerico Giovanni, Calvieri Camilla, Vicario Tommasa, Russo Roberta, Saliola Mirella, Del Ben Maria, Angelico Francesco, Bucci Tommaso, Baratta Francesco, DATA AND SAFETY MONITORING BOARD (DSMB): Vestri Anna Rita, Farcomeni Alessio, Di Tanna Gianluca, STUDY COORDINATORS: Basili Stefania, Davi’ Giovanni, STEERING COMMITTEE OF ARAPACIS STUDY: Violi Francesco, Perticone Francesco, Lip Gregory YH, Hiatt William R, Vestri Anna Rita, Corazza Gino Roberto, Mannucci Pier Mannuccio, Licata Giuseppe, Moroni Carlo, Proietti Marco, Anzaldi Massimiliano, Bazzini Cristina, Bianchi Paola Ilaria, Boari Benedetta, Bracco Christian, Buonauro Agostino, Buttà Carmelo, Buzzetti Elena, Calabria Stefano, Capeci William, Carleo Pietro, Carrabba Maria Domenica, Castorani Luigi, Cecchetto Lara, Cimini Claudia, Colombo Barbara Maria, De Giorgi Alfredo, De Vuono Stefano, Denegri Andrea, Del Corso Lisette, Di Giosia Paolo, Durante Mangoni Emanuele, Falsetti Lorenzo, Forgione Alessandra, Grassi Davide, Grembiale Alessandro, Hijazi Daniel, Iamele Luigi, Lorusso Giusi, Marra Alberto Maria, Masala Maristella, Montebianco Abenavoli Ludovico, Murgia Giuseppe, Naccarato Paola, Pattoneri Paolo, Perego Francesca, Pesce Paola, Petramala Luigi, Pinto Daniela, Pinna Miriam Pretti Vincenzo, Pucci Giacomo, Raparelli Valeria, Salinaro Francesco, Santilli Francesca, Scarpini Francesca, Sirico Domenico, Suppressa Patrizia, Tassone Eliezer Joseph, Torres Daniele, Vazzana Natale, Vecchio Claudia Rita, Vidili Gianpaolo, Vitale Francesco, Proietti, M., Marra, A., Tassone, E., De Vuono, S., Corrao, S., Gobbi, P., Perticone, F., Corazza, G., Basili, S., Lip, G., Violi, F., Raparelli, V., Marra, A. M., Tassone, E. J., Corazza, G. R., and Lip, G. Y. H.

Subjects
Registrie, Male, Cross-sectional study, Myocardial Infarction, Longitudinal Studie, Left ventricular hypertrophy, Cohort Studies, non-valvular atrial fibrillation, Atrial Fibrillation, 80 and over, Prevalence, echocardiography, Myocardial infarction, Longitudinal Studies, Prospective Studies, Registries, Prospective cohort study, Ultrasonography, Aged, 80 and over, education.field_of_study, Medicine (all), Atrial fibrillation, Diabetes Mellitu, Middle Aged, Left Ventricular, left ventricular hypertrophy, Italy, Hypertension, Cardiology, Age Distribution, Aged, Ankle Brachial Index, Cross-Sectional Studies, Diabetes Mellitus, Female, Humans, Hypertrophy, Left Ventricular, Logistic Models, Peripheral Arterial Disease, Cardiology and Cardiovascular Medicine, Human, medicine.medical_specialty, Logistic Model, Population, Concentric hypertrophy, Socio-culturale, non-valvular atrial fibrillation, left ventricular hypertrophy, echocardiography, cardiovascular diseases, Internal medicine, medicine, cardiovascular diseases, education, Cross-Sectional Studie, business.industry, Odds ratio, Hypertrophy, medicine.disease, Prospective Studie, Cohort Studie, business
Abstract

Left ventricular hypertrophy (LVH) is significantly related to adverse clinical outcomes in patients at high risk of cardiovascular events. In patients with atrial fibrillation (AF), data on LVH, that is, prevalence and determinants, are inconsistent mainly because of different definitions and heterogeneity of study populations. We determined echocardiographic-based LVH prevalence and clinical factors independently associated with its development in a prospective cohort of patients with non-valvular (NV) AF. From the "Atrial Fibrillation Registry for Ankle-brachial Index Prevalence Assessment: Collaborative Italian Study" (ARAPACIS) population, 1,184 patients with NVAF (mean age 72 ± 11 years; 56% men) with complete data to define LVH were selected. ARAPACIS is a multicenter, observational, prospective, longitudinal on-going study designed to estimate prevalence of peripheral artery disease in patients with NVAF. We found a high prevalence of LVH (52%) in patients with NVAF. Compared to those without LVH, patients with AF with LVH were older and had a higher prevalence of hypertension, diabetes, and previous myocardial infarction (MI). A higher prevalence of ankle-brachial index ≤0.90 was seen in patients with LVH (22 vs 17%, p = 0.0392). Patients with LVH were at significantly higher thromboembolic risk, with CHA2DS2-VASc ≥2 seen in 93% of LVH and in 73% of patients without LVH (p

Published
2015
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