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34 results on '"Negrín-Mena, Natalia"'

2. The error of estimated GFR in predialysis care

Author

Escamilla-Cabrera, Beatriz, Luis-Lima, Sergio, Gallego-Valcarce, Eduardo, Sánchez-Dorta, Nuria Victoria, Negrín-Mena, Natalia, Díaz-Martín, Laura, Cruz-Perera, Coriolano, Hernández-Valles, Ana Monserrat, González-Rinne, Federico, Rodríguez-Gamboa, María José, Estupiñán-Torres, Sara, Miquel-Rodríguez, Rosa, Cobo-Caso, María Ángeles, Delgado-Mallén, Patricia, Fernández-Suárez, Gema, González-Rinne, Ana, Hernández-Barroso, Grimanesa, González-Delgado, Alejandra, Torres-Ramírez, Armando, Jiménez-Sosa, Alejandro, Ortiz, Alberto, Gaspari, Flavio, Hernández-Marrero, Domingo, and Porrini, Esteban Luis

Published
2024
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3. Exercise and Prediabetes After Renal Transplantation (EXPRED-I): A Prospective Study

Author

Morales Febles, Raúl, Marrero Miranda, Domingo, Jiménez Sosa, Alejandro, González Rinne, Ana, Cruz Perera, Coriolano, Rodríguez-Rodríguez, Ana Elena, Álvarez González, Alejandra, Díaz Martín, Laura, Negrín Mena, Natalia, Acosta Sørensen, Cristian, Pérez Tamajón, Lourdes, Rodríguez Hernández, Aurelio, González Rinne, Federico, Dorta González, Aday, Ledesma Pérez, Eusebio, González Delgado, Alejandra, Domínguez-Rodríguez, Alberto, García Baute, Maria del Carmen, Torres Ramírez, Armando, and Porrini, Esteban

Published
2023
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4. The Role of Vascular Lesions in Diabetes Across a Spectrum of Clinical Kidney Disease

Author

Rodríguez-Rodríguez, Rosa, Hojs, Radovan, Trevisani, Francesco, Morales, Enrique, Fernández, Gema, Bevc, Sebastjan, Cases Corona, Clara María, Cruzado, Josep María, Quero, María, Navarro Díaz, Maruja, Bettiga, Arianna, Di Marco, Federico, López Martínez, Marina, Moreso, Francisco, García Garro, Clara, Khazim, Khaled, Ghanem, Fedaa, Praga, Manuel, Ibernón, Meritxell, Laranjinha, Ivo, Mendonça, Luís, Bigotte Vieira, Miguel, Hornum, Mads, Feldt-Rasmussen, Bo, Fernández-Fernández, Beatriz, Concepción, Patricia Fox, Negrín Mena, Natalia, Ortiz, Alberto, and Porrini, Esteban

Published
2021
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5. The estimation of GFR and the adjustment for BSA in overweight and obesity: a dreadful combination of two errors

Author

López-Martínez, Marina, Luis-Lima, Sergio, Morales, Enrique, Navarro-Díaz, Maruja, Negrín-Mena, Natalia, Folgueras, Tomás, Escamilla, Beatriz, Estupiñán, Sara, Delgado-Mallén, Patricia, Marrero-Miranda, Domingo, González-Rinne, Ana, Miquel-Rodríguez, Rosa María, Cobo-Caso, Maria Angeles, Díaz-Martín, Laura, Jiménez-Sosa, Alejandro, González-Rinne, Federico, Torres, Armando, and Porrini, Esteban

Published
2020
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6. Estimated GFR Slope in Kidney Transplant Patients: When the Error Is Random

Author

Luis Lima, Sergio, Marrero Miranda, Domingo, González Rinne, Ana, Negrín Mena, Natalia, Pérez Tamajón, Lourdes, Rodríguez, Aurelio, Alvarez González, Alejandra, González Delgado, Alejandra, Ferrer Moure, Carmen, González Rinne, Federico, Martín, Laura Díaz, Rodríguez Rodríguez, Ana Elena, Gómez Díaz, Laura, García Cabrera, Verónica, Jiménez Sosa, Alejandro, Torres, Armando, Ortiz, Alberto, Gaspari, Flavio, and Porrini, Esteban

Published
2022
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7. Estimated glomerular filtration rate by formulas in patients with cirrhosis: An unreliable procedure

Author

González‐Alayón, Carlos, primary, Porrini, Esteban, additional, Luis‐Lima, Sergio, additional, Negrín‐Mena, Natalia, additional, Moreno, Miguel, additional, Morales‐Arráez, Dalia, additional, González‐Rinne, Federico, additional, Díaz‐Martín, Laura, additional, Gaspari, Flavio, additional, González‐Delgado, Alejandra, additional, Ferrer‐Moure, Carmen, additional, Ortiz‐Arduán, Alberto, additional, and Hernandez‐Guerra, Manuel, additional

Published
2022
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8. Review on the management of cardiovascular risk factors in the elderly.

Author

González-Colaço Harmand, Magali, del Mar García-Sanz, María, Agustí, Antònia, César Prada-Arrondo, Pablo, Domínguez-Rodríguez, Alberto, Grandal-Leirós, Beatriz, Peña-Otero, David, Negrín-Mena, Natalia, Javier López-Hernández, Jesús, and Díez-Villanueva, Pablo

Subjects
OBESITY complications, DIABETES complications, CARDIOVASCULAR diseases risk factors, SEDENTARY lifestyles, HYPERTENSION, FRAIL elderly, AGE, MEDICAL care, RISK assessment, HYPERLIPIDEMIA, QUALITY of life, METABOLIC syndrome, SMOKING, ELDER care, DISEASE complications, OLD age
Abstract

Cardiovascular risk factors (CVRF) are very prevalent in the elderly population and in addition to predisposing to cardiovascular disease they are related to functional decline, which limits the quality of life in this population. The objective of this work is to offer a review of the current evidence in the management of CVRF in the elderly population. The search strategy was executed in PubMed, Clinicalstrials.org and Embase, to search for clinical trials, observational cohort or cross-sectional studies, reviews, and clinical practice guidelines focused or including elderly population. The results provided were refined after reading the title and abstract, as well as elimination of duplicates, and were finally identified and assessed following the GRADE methodology. A total of 136 studies were obtained for all predefined risk factors, such as sedentary lifestyle, smoking, obesity and metabolic syndrome, hypertension, diabetes mellitus, dyslipidemia and alcohol. We described the results of the studies identified and assessed according to their methodological quality in different recommendation sections: diagnostic and prevention, intervention, or treatment in the elderly population. As the main limitation to the results of this review, there is the lack of quality studies whose target population is elderly patients. This issue limits the recommendations that can be made in this population. Due to this reason, comprehensive geriatric assessment seems the best tool currently available to implement the most appropriate treatment plans based on the baseline situation and comorbidity of each elderly patient. [ABSTRACT FROM AUTHOR]

Published
2022
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9. Estimated GFR Slope in Kidney Transplant Patients: When the Error Is Random

Author

Luis Lima, Sergio, primary, Marrero Miranda, Domingo, additional, González Rinne, Ana, additional, Negrín Mena, Natalia, additional, Pérez Tamajón, Lourdes, additional, Rodríguez, Aurelio, additional, Alvarez González, Alejandra, additional, González Delgado, Alejandra, additional, Ferrer Moure, Carmen, additional, González Rinne, Federico, additional, Martín, Laura Díaz, additional, Rodríguez Rodríguez, Ana Elena, additional, Gómez Díaz, Laura, additional, García Cabrera, Verónica, additional, Jiménez Sosa, Alejandro, additional, Torres, Armando, additional, Ortiz, Alberto, additional, Gaspari, Flavio, additional, and Porrini, Esteban, additional

Published
2021
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10. Exercise and Prediabetes after Renal Transplantation (EXPRED): Protocol Description

Author

Morales Febles, Raúl, primary, Negrín Mena, Natalia, additional, Rodríguez-Rodríguez, Ana Elena, additional, Díaz Martín, Laura, additional, González Rinne, Federico, additional, Marrero Miranda, Domingo, additional, González Rinne, Ana, additional, Álvarez González, Alejandra, additional, Pérez Tamajón, Lourdes, additional, Acosta Sørensen, Cristian, additional, Rodríguez Hernández, Aurelio, additional, Domínguez-Rodríguez, Alberto, additional, García Baute, Maria del Carmen, additional, Torres Ramírez, Armando, additional, and Porrini, Esteban, additional

Published
2020
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12. Renal Function Assessment Gap in Clinical Practice: An Awkward Truth

Author

Trevisani, Francesco, primary, Di Marco, Federico, additional, Capitanio, Umberto, additional, Larcher, Alessandro, additional, Bettiga, Arianna, additional, Dosio, Flaviano, additional, Ghidini, Michele, additional, Del Conte, Gianluca, additional, Vago, Riccardo, additional, Cinque, Alessandra, additional, Gianolli, Luigi, additional, Salonia, Andrea, additional, Briganti, Alberto, additional, Luis-Lima, Sergio, additional, Negrín-Mena, Natalia, additional, Montorsi, Francesco, additional, and Porrini, Esteban, additional

Published
2020
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13. The estimation of GFR and the adjustment for BSA in overweight and obesity: a dreadful combination of two errors

Author

López-Martínez, Marina, primary, Luis-Lima, Sergio, additional, Morales, Enrique, additional, Navarro-Díaz, Maruja, additional, Negrín-Mena, Natalia, additional, Folgueras, Tomás, additional, Escamilla, Beatriz, additional, Estupiñán, Sara, additional, Delgado-Mallén, Patricia, additional, Marrero-Miranda, Domingo, additional, González-Rinne, Ana, additional, Miquel-Rodríguez, Rosa María, additional, Cobo-Caso, Maria Angeles, additional, Díaz-Martín, Laura, additional, Jiménez-Sosa, Alejandro, additional, González-Rinne, Federico, additional, Torres, Armando, additional, and Porrini, Esteban, additional

Published
2019
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14. The Error of Estimated GFR in Type 2 Diabetes Mellitus

Author

Luis-Lima, Sergio, primary, Higueras Linares, Tomás, additional, Henríquez-Gómez, Laura, additional, Alonso-Pescoso, Raquel, additional, Jimenez, Angeles, additional, López-Hijazo, Asunción María, additional, Negrín-Mena, Natalia, additional, Martín, Candelaria, additional, Sánchez-Gallego, Macarena, additional, Galindo-Hernández, Sara Judith, additional, Socas Fernández del Castillo, Raquel, additional, Castilla-Marrero, Manuel, additional, Domínguez-Coello, Santiago, additional, Vilchez de León, Vanesa, additional, Valcárcel-Lopez, Rafael, additional, Insausti-Garmendia, Nerea, additional, Escamilla, Beatriz, additional, Estupiñán, Sara, additional, Delgado-Mallén, Patricia, additional, Armas-Padrón, Ana-María, additional, Marrero-Miranda, Domingo, additional, González-Rinne, Ana, additional, Miquel Rodríguez, Rosa María, additional, Cobo-Caso, María Angeles, additional, Díaz-Martín, Laura, additional, González-Rinne, Federico, additional, González-Delgado, Alejandra, additional, López-Martínez, Marina, additional, Jiménez-Sosa, Alejandro, additional, Torres, Armando, additional, and Porrini, Esteban, additional

Published
2019
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15. SP265THE ESTIMATION OF GFR AND THE ADJUSTMENT FOR BSA IN OVERWEIGHT AND OBESITY: A DREADFUL COMBINATION OF TWO ERRORS

Author

López-Martínez, Marina, primary, Morales, Enrique, additional, Navarro, Maru, additional, Luis-Lima, Sergio, additional, Escamilla, Beatriz, additional, Negrín-Mena, Natalia, additional, Delgado-Mallén, Patricia, additional, Marrero-Miranda, Domingo, additional, González-Rinne, Ana, additional, Miquel, Rosa, additional, Cobo, Marian, additional, Díaz-Martín, Laura, additional, González-Rinne, Federico, additional, González-Delgado, Alejandra, additional, Torres, Armando, additional, and Porrini, Esteban, additional

Published
2019
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16. Impact of errors of creatinine and cystatin C equations in the selection of living kidney donors

Author

González-Rinne, Ana, primary, Luis-Lima, Sergio, additional, Escamilla, Beatriz, additional, Negrín-Mena, Natalia, additional, Ramírez, Ana, additional, Morales, Adelaida, additional, Vega, Nicanor, additional, García, Patricia, additional, Cabello, Elisa, additional, Marrero-Miranda, Domingo, additional, Aldea-Perona, Ana, additional, Alvarez, Alejandra, additional, Abad, María del Carmen, additional, Pérez-Tamajón, Lourdes, additional, González-Rinne, Federico, additional, González-Delgado, Alejandra, additional, Díaz Martín, Laura, additional, Jiménez-Sosa, Alejandro, additional, Torres, Armando, additional, and Porrini, Esteban, additional

Published
2019
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17. Exercise and Prediabetes after Renal Transplantation (EXPRED): Protocol Description.

Author

Morales Febles, Raúl, Negrín Mena, Natalia, Rodríguez-Rodríguez, Ana Elena, Díaz Martín, Laura, González Rinne, Federico, Marrero Miranda, Domingo, González Rinne, Ana, Álvarez González, Alejandra, Pérez Tamajón, Lourdes, Acosta Sørensen, Cristian, Rodríguez Hernández, Aurelio, Domínguez-Rodríguez, Alberto, García Baute, Maria del Carmen, Torres Ramírez, Armando, and Porrini, Esteban

Published
2021
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18. Chronic kidney disease staging with cystatin C or creatinine-based formulas: flipping the coin

Author

Luis-Lima, Sergio, primary, Escamilla-Cabrera, Beatriz, additional, Negrín-Mena, Natalia, additional, Estupiñán, Sara, additional, Delgado-Mallén, Patricia, additional, Marrero-Miranda, Domingo, additional, González-Rinne, Ana, additional, Miquel-Rodríguez, Rosa, additional, Cobo-Caso, María Ángeles, additional, Hernández-Guerra, Manuel, additional, Oramas, Juana, additional, Batista, Norberto, additional, Aldea-Perona, Ana, additional, Jorge-Pérez, Pablo, additional, González-Alayón, Carlos, additional, Moreno-Sanfiel, Miguel, additional, González-Rodríguez, Juan Antonio, additional, Henríquez, Laura, additional, Alonso-Pescoso, Raquel, additional, Díaz-Martín, Laura, additional, González-Rinne, Federico, additional, Lavín-Gómez, Bernardo Alio, additional, Galindo-Hernández, Judith, additional, Sánchez-Gallego, Macarena, additional, González-Delgado, Alejandra, additional, Jiménez-Sosa, Alejandro, additional, Torres, Armando, additional, and Porrini, Esteban, additional

Published
2018
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19. SP432THE ERROR OF ESTIMATED GFR Y TYPE 2 DIABETES

Author

Luis-Lima, Sergio, primary, Negrín-Mena, Natalia, additional, Alonso-Pescoso, Raquel, additional, Henríquez, Laura, additional, Díaz-Martín, Laura, additional, Torres, Armando, additional, and Porrini, Esteban, additional

Published
2018
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21. A Simple Method to Measure Renal Function in Swine by the Plasma Clearance of Iohexol

Author

Luis-Lima, Sergio, García-Contreras, Consolación, Vázquez Gómez, Marta, Astiz, Susana, Carrara, Fabiola, Gaspari, Flavio, Negrín-Mena, Natalia, Jiménez-Sosa, Alejandro, Jiménez-Hernández, Hugo, González Bulnes, Antonio, Porrini, Esteban, Luis-Lima, Sergio, García-Contreras, Consolación, Vázquez Gómez, Marta, Astiz, Susana, Carrara, Fabiola, Gaspari, Flavio, Negrín-Mena, Natalia, Jiménez-Sosa, Alejandro, Jiménez-Hernández, Hugo, González Bulnes, Antonio, and Porrini, Esteban

Abstract

There is no simple method to measure glomerular filtration rate (GFR) in swine, an established model for studying renal disease. We developed a protocol to measure GFR in conscious swine by using the plasma clearance of iohexol. We used two groups, test and validation, with eight animals each. Ten milliliters of iohexol (6.47 g) was injected into the marginal auricular vein and blood samples (3 mL) were collected from the orbital sinus at different points after injection. GFR was determined using two models: two-compartment (CL2: all samples) and one-compartment (CL1: the last six samples). In the test group, CL1 overestimated CL2 by ~30%: CL2 = 245 ± 93 and CL1 = 308 ± 123 mL/min. This error was corrected by a first-order polynomial quadratic equation to CL1, which was considered the simplified method: SM = −47.909 + (1.176xCL1) − (0.00063968xCL12). The SM showed narrow limits of agreement with CL2, a concordance correlation of 0.97, and a total deviation index of 14.73%. Similar results were obtained for the validation group. This protocol is reliable, reproducible, can be performed in conscious animals, uses a single dose of the marker, and requires a reduced number of samples, and avoids urine collection. Finally, it presents a significant improvement in animal welfare conditions and handling necessities in experimental trials., Unión Europea. FP7, European Cooperation in Science and Technology (COST), Ministerio de Economía y Competitividad (MINECO)/Programa Ramón y Cajal, Insituto de Salud Carlos III (ISCIII), Red de Investigación Renal (REDINREN), Depto. de Producción Animal, Fac. de Veterinaria, TRUE, pub

Published
2018

23. A Simple Method to Measure Renal Function in Swine by the Plasma Clearance of Iohexol

Author

Luis-Lima, Sergio, primary, García-Contreras, Consolación, additional, Vázquez-Gómez, Marta, additional, Astiz, Susana, additional, Carrara, Fabiola, additional, Gaspari, Flavio, additional, Negrín-Mena, Natalia, additional, Jiménez-Sosa, Alejandro, additional, Jiménez-Hernández, Hugo, additional, González-Bulnes, Antonio, additional, and Porrini, Esteban, additional

Published
2018
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24. Colaboradores

Author

Abizanda Soler, Pedro, Agudo Mena, José Luis, Aguilar, Adriana B., Alarcón Alarcón, Teresa, Albrecht Junghanns, Rodolfo Emmanuel, Alfaro Acha, Ana, Almaida Pagán, Pedro Francisco, Alonso Bouzón, Cristina, Alonso Fernández, Teresa, Alvira Rasal, Berta, Andradas Aragonés, Elena, Andrés Lacueva, Cristina, Angulo Frutos, Javier, Arche Coto, José Miguel, Ariza Zafra, Gabriel, Arriola Manchola, Enrique, Avellana Zaragoza, Juan Antonio, Avendaño Céspedes, Almudena, Defez, José Manuel Azaña, Elías, Íñigo Azcoitia, Balducci, Lodovico, Bardales Mas, Yadira, Baztán Cortés, Juan José, Varea, Ángel Belenguer, Bermeo Serrato, Sandra Milena, Menéndez de la Granda, Manuel Bermúdez, Borrás Blasco, Consuelo, Burcet Pérez, Silvia, Mora, María Ángeles Caballero, Cabré Roure, Mateu, Calcaterra, Laura, Camilo Beltrán, Jonathan, Cano Gutiérrez, Carlos Alberto, Casas Agustench, Patricia, Herrero, Álvaro Casas, Castro Rodríguez, Marta, Cebollero Ribas, Pilar, Celaya Cifuentes, Sara, Cesari, Matteo, Chavarro Carvajal, Diego Andrés, Chaves, Paulo H.M., Chodzko-Zajko, Wojtek, Clavé Civit, Pere, Contreras Escámez, Beatriz, Contreras Luque, Claudia Patricia, Santiago, Dámaso Crespo, Allue, Ramón Cristófol, Cristofori, Giovanna, María Cuervo, Ana, Cuesta Triana, Federico, Curcio Borrero, Carmen Lucía, de Costa Ruiz, Jorge, Rey, Mónica de la Fuente del, de la Fuente Gutiérrez, Carlos, Martín, María de la Puente, del Pozo Guerrero (D.E.P.), Francisco, Domínguez Martín, Laura, Duque Naranjo, Gustavo, Durio Calero, Enrique Antonio, Enfedaque Montes, Belén, Escobar Gómez, Lina María, Esquinas Requena, José Luis, Esteve Arríen, Ainhoa, Estrella Cazalla, Juan de Dios, Fernández, Agustín F., Fernández, Iñaki Fernández de Trocóniz, Fernández Fernández, María, Fernández Martínez, Nuria, Fernández Minaya, Dionis Carolina, Fernández Rodríguez, Esperanza, Fernández Viadero, Carlos, Flores Ruano, Teresa, Fraga, Mario F., Galmés Belmonte, Ignacio, Gambini Buchón, Juan, Garatachea Vallejo, Nuria, Garcia Cifuentes, Elkin, García Esquinas, Esther, García García, Francisco José, García Navarro, José Augusto, García Sánchez, Sergio, García Segura, Luis Miguel, Garreta Buriel, Marisa, Garrido Cid, María Jesús, Gil Gregorio, Pedro, Gimeno Mallench, Lucía, Gómez Fernández, Marisol, Gómez Montes, Fernando, Gómez Pavón, Javier, González-Colaço Harmand, Magali, González García, Paloma, González Guerrero, José Luis, González Montalvo, Juan Ignacio, Gramunt Fombuena, Nina, Grande Martín, Alberto, Guerrero Díaz, María Teresa, Luis Guerrero Solano, José, Gutiérrez Robledo, Luis Miguel, Gutiérrez Rodríguez, José, Hendry, Anne, Heras Benito, Manuel, Hernández Zamora, Paulo, Hernández Zegarra, Pablo Alberto, Hoogendijk, Emiel O., Hornillos Calvo, Mercedes, Huedo Rodenas, Isabel, Pérez de Heredia, Javier Hueto, Ibarzábal Aramberri, Xabier, Inzitari, Marco, Izquierdo Redín, Mikel, Jiménez Muela, Francisco, Jiménez Rojas, Concepción, Jiménez Segura, José Daniel, Jordán Bueso, Joaquín, Jové Font, Mariona, Júdez Navarro, Enrique, Juncos Martínez, Gema, Laosa Zafra, Olga, León Ortiz, Matilde, Limón Ramírez, Esther, Linge Martín, Magdalena, Arrieta, Jesús María López, Chicharro, José Luis López, López-Dóriga Bonnardeaux, Pedro, López García, Esther, López Jiménez, Esther, Sáez de Asteasu, Mikel López, López Utiel, Melisa, Lozano Berrio, Vicente, Lozano Montoya, Isabel, Lucía Mulas, Alejandro, Luengo Márquez, Carmen, Madrid Pérez, Juan Antonio, Manzarbeitia Arambarri, Jorge, Fuentes, Ángel Martín, Martín Martínez, Alberto, Martín Sanz, Eduardo, Sebastiá, Asunción Martín, Martín Sebastiá, Elena, Luz Martínez, Iveris, Martínez Antón, Miguel Ángel, Montandón, Álvaro Martínez, Martínez Ramírez, Alicia, Martínez Reig, Marta, Velilla, Nicolás Martínez, Mas Bergas, Miquel Àngel, Mas Romero, Marta, Matheu, Ander, Mazoteras Muñoz, Virginia, Miguel Alhambra, Luciana, Millor Muruzábal, Nora, Basseda, Ramón Miralles, Mohedano Molano, Julia, Garrido, María José Molina, Molina Olivas, Marta, Guix, José Luis Molinuevo, Montero Moreno, Javier Antonio, Montero-Odasso, Manuel, Morales Martínez, Fernando, Moreno Cugnon, Leire, Moreno Valladares, Manuel, Mosquera Gorostidi, Carmen, Negrín Mena, Natalia, Noguerón García, Alicia, Ochando Ibernón, Gemma, Olaso González, Gloria, Oliva Moreno, Juan, Carbonell, José Luis Oliver, Ortega Fernández, Omar, Pamplona Gras, Reinald, Fernández, José Manuel Pardal, Pareja Galeano, Helios, Pareja Sierra, Teresa, García, José Francisco Parodi, Pedraza Sepúlveda, Laura, Peláez, Martha B., Peña Longobardo, Luz María, Pérez Bazán, Laura Mónica, Pérez-Jara Carrera, Javier, Pérez Rodríguez, Rodrigo, Pérez Rojo, Gema, Petidier Torregrossa, Roberto, Pradas Barriga, Irene, Villanueva, Begoña Prado, Prieto Prieto, Fernando, Puertas Cuesta, Francisco Javier, Puyol Antolín, Rafael, Ramos Bacco, Mauricio, Rangel Selvera, Omar, Rexach Cano, Lourdes, Rodríguez Artalejo, Fernando, Rodríguez Mañas, Leocadio, Rodríguez Sánchez, Beatriz, Rodríguez Sánchez, Isabel, Rodríguez Solís, Juan, Lama, María Ángeles Rol de, Romero Macías, Juan Ramón, Romero Rizos, Luis, Ruiz Medrano, Jorge, Ruiz-Moreno, José María, Ruiz Sáenz, Pedro Luis, Salas Carrillo, Mario, Cristóbal Velasco, Esther San, Sánchez Castellano, Carmen, Sánchez Jurado, Pedro Manuel, Nievas, Ginés Sánchez, Escudero, José Manuel Santacruz, Sanz Fernández, Ricardo, Schwingel, Andiara, Scuteri, Angelo, Sierra, Marta I., Sinclair, Alan J., Solano Jaurrieta, Juan José, Soler Moratalla, Isabel, Rodríguez, María del Carmen Soriano, Tarazona Santabalbina, Francisco, Tardáguila García, Noelia, Tasset, Inmaculada, Dorta, Agustín Tejera, Ucha Domingo, Marisol, Urpi Sarda, Mireia, van Leeuwen, Mara, Vega García, Enrique, Verdejo Bravo, Carlos, Verduga Vélez, Rosario, Vial Escolano, Raquel, Vilches Moraga, Arturo, Ribes, José Viña, Walston, Jeremy, Yubero Pancorbo, Raquel, Zambom-Ferraresi, Fabrício, and Zúñiga Gil, Clemente Humberto

Published
2020
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25. Iohexol plasma clearance simplified by dried blood spot testing

Author

Luis-Lima, Sergio, primary, Gaspari, Flavio, additional, Negrín-Mena, Natalia, additional, Carrara, Fabiola, additional, Díaz-Martín, Laura, additional, Jiménez-Sosa, Alejandro, additional, González-Rinne, Federico, additional, Torres, Armando, additional, and Porrini, Esteban, additional

Published
2017
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27. MP308USING ESTIMATED GFR TO DIAGNOSE CKD STAGES: FLICKING THE COIN

Author

Porrini, Esteban, primary, Luis-Lima, Sergio, additional, Estupiñán, Sara, additional, Delgado, Patricia, additional, Cobo, Mariam, additional, Miquel, Rosa, additional, González-Delgado, Alejandra, additional, Negrín-Mena, Natalia, additional, Marrero, Domingo, additional, Aldea-Perona, Ana, additional, González-Rinne, Federico, additional, Díaz-Martín, Laura, additional, and Torres, Armando, additional

Published
2017
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29. MP321WHEN CREATININE CLEARANCE AND ESTIMATED GFR DO NOT AGREE: THE ROLE OF MEASURED GFR IN CLINICAL PRACTICE

Author

Porrini, Esteban, primary, Estupiñán, Sara, additional, González-Delgado, Alejandra, additional, Delgado, Patricia, additional, Cobo, Mariam, additional, Rodríguez, Aurelio, additional, Miquel, Rosa, additional, Luis-Lima, Sergio, additional, Negrín-Mena, Natalia, additional, Díaz-Martín, Laura, additional, and Torres, Armando, additional

Published
2017
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30. SP666ESTIMATED GFR TO EVALUATE RENAL FUNCTION IN PREDIALYSIS PATIENTS: A SHOT IN THE DARK

Author

Escamilla, Beatriz, primary, Gallego-Valcarce, Eduardo, additional, Negrín-Mena, Natalia, additional, Gil Gabarrón, María Soledad, additional, Luis-Lima, Sergio, additional, Cerda-Bejar, Ana María, additional, Fernández-Juarez, Gema, additional, González-Rinne, Federico, additional, González-Delgado, Alejandra, additional, Díaz-Martín, Laura, additional, Cofrade Vega, Raquel, additional, Torres, Armando, additional, and Porrini, Esteban, additional

Published
2017
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31. Chronic kidney disease staging with cystatin C or creatinine-based formulas: flipping the coin.

Author

Luis-Lima, Sergio, Escamilla-Cabrera, Beatriz, Negrín-Mena, Natalia, Estupiñán, Sara, Delgado-Mallén, Patricia, Marrero-Miranda, Domingo, González-Rinne, Ana, Miquel-Rodríguez, Rosa, Cobo-Caso, María Ángeles, Hernández-Guerra, Manuel, Oramas, Juana, Batista, Norberto, Aldea-Perona, Ana, Jorge-Pérez, Pablo, González-Alayón, Carlos, Moreno-Sanfiel, Miguel, González-Rodríguez, Juan Antonio, Henríquez, Laura, Alonso-Pescoso, Raquel, and Díaz-Martín, Laura

Subjects
KIDNEY diseases, GLOMERULAR filtration rate, CHRONIC diseases
Abstract

Background Chronic kidney disease (CKD) affects 10–13% of the population worldwide. CKD classification stratifies patients in five stages of risk for progressive renal disease based on estimated glomerular filtration rate (eGFR) by formulas and albuminuria. However, the reliability of formulas to reflect real renal function is a matter of debate. The effect of the error of formulas in the CKD classification is unclear, particularly for cystatin C–based equations. Methods We evaluated the reliability of a large number of cystatin C and/or creatinine-based formulas in the definition of the stages of CKD in 882 subjects with different clinical situations over a wide range of glomerular filtration rates (GFRs) (4.2–173.7 mL/min). Results Misclassification was a constant for all 61 formulas evaluated and averaged 50% for creatinine-based and 35% for cystatin C–based equations. Most of the cases were misclassified as one stage higher or lower. However, in 10% of the subjects, one stage was skipped and patients were classified two stages above or below their real stage. No clinically relevant improvement was observed with cystatin C–based formulas compared with those based on creatinine. Conclusions The error in the classification of CKD stages by formulas was extremely common. Our study questions the reliability of both cystatin C and creatinine-based formulas to correctly classify CKD stages. Thus the correct classification of CKD stages based on estimated GFR is a matter of chance. This is a strong limitation in evaluating the severity of renal disease, the risk for progression and the evolution of renal dysfunction over time. [ABSTRACT FROM AUTHOR]

Published
2019
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32. Iohexol plasma clearance simplified by dried blood spot testing.

Author

Luis-Lima, Sergio, Gaspari, Flavio, Negrín-Mena, Natalia, Carrara, Fabiola, Díaz-Martín, Laura, Jiménez-Sosa, Alejandro, González-Rinne, Federico, Torres, Armando, and Porrini, Esteban

Subjects
DRIED blood spot testing, IOHEXOL, GLOMERULAR filtration rate, KIDNEY function tests, VOLUMETRIC analysis
Abstract

Background Renal function can be estimated with formulas, which are inaccurate, or measured with gold standard methods, which are reliable but unpractical. We propose to simplify the plasma clearance of iohexol, a gold standard method to measure renal function, by dried blood spot (DBS) testing. Methods We compared glomerular filtration rate (GFR) values assessed by DBS and the reference plasma analysis technique. We tested in vitro the agreement between non-volumetric and volumetric DBS with the reference technique. Then, we performed a clinical validation in vivo between volumetric DBS and plasma analysis in 203 patients. The agreement was evaluated with the concordance correlation coefficient (CCC), the total deviation index (TDI) and the coverage probability. We defined acceptable agreement as a TDI <10%. Results In the in vitro studies, the non-volumetric DBS showed moderate agreement, TDI = 26.0%, while the volumetric method showed better but insufficient agreement, TDI = 13.0%, with the reference method in plasma. The non-volumetric DBS was rejected. To improve the agreement of the volumetric DBS, iopamidol was used as an internal standard. This method showed acceptable agreement, TDI = 9.0% with the analysis in plasma, and was selected as the definitive DBS method. In the in vivo studies, the agreement between the final DBS method and the reference technique was acceptable: TDI = 9.5%. This indicates that 90% of the GFR values ranged from −9.5% to + 9.5% compared with the reference method. Conclusions We simplified the plasma clearance of iohexol using DBS without losing accuracy and precision with respect to the reference technique. This may facilitate the use of a reliable determination of renal function to the medical community. [ABSTRACT FROM AUTHOR]

Published
2018
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33. Estimated Glomerular Filtration Rate in Renal Transplantation

Author

Luis-Lima, Sergio, primary, Marrero-Miranda, Domingo, additional, González-Rinne, Ana, additional, Torres, Armando, additional, González-Posada, José M., additional, Rodríguez, Aurelio, additional, Salido, Eduardo, additional, Aldea-Perona, Ana, additional, Gaspari, Flavio, additional, Carrara, Fabiola, additional, Gómez-Gerique, Juan A., additional, Negrín-Mena, Natalia, additional, Pérez-Tamajón, Lourdes, additional, González-Rinne, Federico, additional, Jiménez-Hernández, Hugo, additional, Jiménez-Sosa, Alejandro, additional, and Porrini, Esteban, additional

Published
2015
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34. Impact of errors of creatinine and cystatin C equations in the selection of living kidney donors.

Author

González-Rinne, Ana, Luis-Lima, Sergio, Escamilla, Beatriz, Negrín-Mena, Natalia, Ramírez, Ana, Morales, Adelaida, Vega, Nicanor, García, Patricia, Cabello, Elisa, Marrero-Miranda, Domingo, Aldea-Perona, Ana, Alvarez, Alejandra, Abad, María del Carmen, Pérez-Tamajón, Lourdes, González-Rinne, Federico, González-Delgado, Alejandra, Martín, Laura Díaz, Jiménez-Sosa, Alejandro, Torres, Armando, and Porrini, Esteban

Subjects
KIDNEYS, EQUATIONS
Published
2020
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