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Fiber Optic Networking on Campus The computing center for Case Western Reserve University (CWRU) in Cleveland is located in Crawford Hall. Most of the 130-acre campus can be seen from […]

With lightning speed, the 'simple' Web-enabled Internet is becoming the technological fabric and glue of a new global society characterized by a bewildering array of virtual, remote relations. Less than [...]

Women in the Collaborative Perinatal Project who received theophylline during pregnancy were no more likely to be delivered of a stillborn infant than were women who did not receive theophylline. [...]

How will the multitudinous varieties of the millennium bug affect the computers and devices we use every day? Time is merciless. The new millennium will come, even if your computer [...]

• Information about point prevalence of depression and anxiety disorders from two cross-sectional surveys in Stirling County (Canada) indicates that an overall prevalence rate of 12.5% characterized a year close to midcentury and a prevalence rate of 12.7% characterized another year toward the end of the century's third quarter. The stability of the prevalence rates contrasts sharply with the fact that numerous social changes took place over this period of time in this place of study. There were, however, small trends in the distribution of depression and anxiety by sex and age, especially an increased similarity in the overall rates for men and women in the age range of 40 to 69 years. Hypotheses are offered about social circumstances that may have influenced the diminishing difference between the sexes.

Pregnancy outcome was analyzed in 147 diabetic women, 71 per cent of whom were dependent on insulin for more than 10 years. Ambulatory management of diabetes was carried out with weekly clinic visits until hospitalization at 36 to 37 weeks' gestation. Modern methods of fetal assessment were applied, and the timing and route of delivery were individualized. Of these patients, 35 per cent were delivered at or beyond 38 weeks' gestation. The primary cesarean section rate was 55 per cent. Polyhydramnios was a frequent maternal complication and was associated with premature labor and neonatal death in two cases. Polyhydramnios was least common in women with the lowest mean outpatient blood glucose. The perinatal survival rate was 96.6 per cent, and there were no instances of unexpected intrauterine fetal death. The incidence of respiratory distress syndrome (RDS) in the newborn infant was 7.6 per cent. No severe RDS was seen when the lecithin/sphingomyelin (L/S) ratio was greater than 3.0, but three of 24 infants delivered with an L/S ratio of 2.1 to 3.0 developed severe RDS. Other forms of neonatal morbidity noted in this population were 9 per cent major congenital anomalies; 7 per cent transient tachypnea of the newborn, 22 per cent hypocalcemia, 19 per cent hyperbilirubinemia, and 47 per cent hypoglycemia. The latter was more common in macrosomic infants, defined as greater than the ninetieth percentile of birth weight for gestational age (LGA), who represented 36 per cent of the neonates. Mean outpatient postprandial blood glucose was higher in patients delivered of LGA infants and was correlated with birth weight in White Classes B to D.

The effect of feeding four synthetic retinoids was evaluated in carcinogen-treated hamsters. Syrian golden hamsters were injected with 20 mg/kg of N-nitrosobis(2-oxopropy1)amine (BOP) and then fed retinoid-supplemented diets for 39 weeks. All retinoid-treated groups grew more slowly than controls, and average survival was shorter in female retinoid-treated groups. A significant incidence of testicular atrophy was noted in male hamsters fed 2-hydroxy-ethylretinamide or 4-carboxyphenylretinamide. The incidence of pancreatic carcinomas was lower in 12 of 14 retinoid-fed groups than in the corresponding control groups, although the differences approached significance only in groups fed two of the retinoids—male hamsters fed N-4-propionyloxyphenylretinamide and those fed retinylidene dimedone. A low incidence of carcinoma in the control groups limits the conclusions that can be drawn from this study, but it is of note that there was no evidence of promotion.