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4. Detecting DUI (Non) deterrence: A macro-methodology to uncover 'restrictive v permissive' county jurisdictions in California

Author

Va Nee L. Van Vleck

Subjects
Permissiveness, Estimation, Automobile Driving, education.field_of_study, Alcohol Drinking, Computer science, Population, Public Health, Environmental and Occupational Health, Human Factors and Ergonomics, California, Law Enforcement, Research Design, Econometrics, Humans, Female, System dynamics model, Deterrence theory, Macro, Permissive, Safety, Risk, Reliability and Quality, education, Set (psychology), Driving Under the Influence, Restrictiveness
Abstract

This paper builds a method to detect the apparent restrictiveness or permissiveness of communities towards drunk-driving. A framework of three mutually interacting community domains is used to motivate a minimum set of DUI patterns to be expected from an appropriately deterrent environment. Based on the (simplified) system dynamics model, an empirical estimation strategy and scoring methodology is outlined. This “macroscopic” approach is demonstrated using results from time-series panel analyses of California’s 58 counties for the years 1990 to 2010 ( Van Vleck et al., 2017 ). The process successfully classified three-quarters of California counties, encompassing almost 90% of the state population. The paper demonstrates a potential tool to classify communities’ systemic behavior toward drinking-and-driving and other enforcement-sensitive subjects.

Published
2019

7. P041 Alemtuzumab-related haemophagocytic lymphohistiocytosis: negotiating the cytokine storm

Author

Rachel Tattersall, David J Paling, Nee L Wong, and Nick J Morley

Subjects
medicine.medical_specialty, Anakinra, business.industry, Hepatosplenomegaly, Case Reports, medicine.disease, medicine.disease_cause, Gastroenterology, Pancytopenia, Autoimmunity, Sepsis, Rheumatology, Methylprednisolone, Internal medicine, medicine, Alemtuzumab, Pharmacology (medical), Eposters, medicine.symptom, business, Cytokine storm, AcademicSubjects/MED00360, medicine.drug
Abstract

Background/Aims Alemtuzumab is an efficacious therapy for relapsing remitting multiple sclerosis (RRMS) preventing neural damage and reducing relapse rate by up to 74%. Administered in 2 treatment cycles 12 months apart and authorised for use in > 40 countries, it is a humanized monoclonal antibody selectively directed against the CD52 antigen of T- and B-Lymphocytes. Significant autoimmune effects of Alemtuzumab are reported 6-60 months post-treatment including secondary autoimmunity (40%), thyroid disease (18-26%), idiopathic thrombocytopenic purpura (1-3%) and anti-glomerular basement membrane disease (1%). There are 2 case reports of haemophagocytic lymphohistiocytosis(HLH) in people with MS triggered by Alemtuzumab. HLH is a clinical syndrome of dysregulated, pathological overactivation of innate immunity leading to cytokine storm, multi-organ failure and a very high mortality rate. Clinical features are difficult to distinguish from, and may coexist with, other syndromes such as sepsis. Recognition requires a high index of clinical suspicion and management through multidisciplinary teams (MDT) using immune suppression. Early recognition and treatment improve outcome. Methods We report a case of HLH in a 30-year-old female 1 year after her first cycle of alemtuzumab (second cycle delayed due to COVID-19 pandemic) for treatment of RRMS. She was well until presentation 2 days post gadolinium-contrasted routine MRI head scan with headache, fever, bacterial pneumonia/empyema and acute kidney injury. Febrile episodes persisted despite antibiotics. Results Investigations revealed hepatosplenomegaly, pancytopenia (Haemoglobin: 80g/L, WBC: 0.9x109/L, neutrophils: 0.67x109/L, lymphocytes: 0.14 X109/L, platelets: 82x109/L), hypertriglyceridaemia (5.5mmol/L) and hyperferritinaemia (94023ng/ml). She fulfilled the Histiocyte Society HLH-2004 diagnostic criteria for HLH (H-score: 238). Initial treatment was IV methylprednisolone (1g) and intravenous immunoglobulin (IVIG) 2g/kg. Ferritin levels initially decreased (66933ng/ml) but re-escalated (93912ng/ml) with clinical deterioration, necessitating additional treatment with subcutaneous Anakinra 4mg/kg(recombinant interleukin-1 receptor antagonist) alongside oral prednisolone 1mg/kg. There was rapid, sustained improvement with resolution of fever but ferritin levels remained highly elevated (45000ng/ml) and cytopaenia was slow to resolve. Marker T cell subsets showed significant T cell depression presumably post-alemtuzumab. MDT discussion locally and nationally through the HLH Across Speciality Collaboration (HASC) led to discharge with careful outpatient monitoring. Further IVIG 2g/kg was administered which led to complete resolution of HLH and treatment wean. Conclusion HLH is an under-recognised complication of alemtuzumab therapy. Severe HLH requires both cytokine storm-directed treatment and identification/treatment of the trigger. Here, HLH was refractory to first line therapy (steroids and IVIG) and required immune modulation. The combination of alemtuzumab-induced immune dysregulation and sepsis were likely triggers, rather than Gadolinium. Supportive regional and national MDT input were required to guide therapy, especially as the patient wished to avoid etoposide (a standard refractory-HLH therapy) to preserve fertility. MDT working enabled early discharge with close monitoring in ambulatory care - a preferred outcome in the coronavirus pandemic. Disclosure N.L. Wong: Grants/research support; In the last 5 years NLW has received educational grant to attend meetings from Eli Lilly. N.J. Morley: Grants/research support; In the last 5 years NJM has received speaker fees and educational grants to attend meetings from ROCHE, AMGEN, AbbVie, TAKEDA, Kite Gilead and Janssen. D.J. Paling: Grants/research support; DJP has recieved speaker fees and educational grants to attend meetings from Biogen, Novartis, Genzyme and Teva. R.S. Tattersall: Grants/research support; In the last 5 years RST has received speaker fees and educational grants to attend meetings from UCB, AbbVie, Pfizer and Janssen.

Published
2021

12. In defense (again) of 'silly little bobtailed' coal wagons: reply to Peter Scott

Author

Van Vleck, Va Nee L.

Subjects
Coal -- Transportation, Railroads -- Freight-cars, Coal industry -- History, Economics, History
Abstract

Peter Scott's analysis of the economics of coal haulage is based on questionable assumptions and a misunderstanding of the operating-cost calculations in a previous article. Scott focuses on ownership rather than on price signals. However, the small coal wagon had economical advantages for the wagon owners.

Published
1999

13. Cops and/or courts? A heterogeneous panel Granger-causality analysis of DUI in California

Author

David Vera and Va Nee L. Van Vleck

Subjects
050210 logistics & transportation, Economics and Econometrics, 05 social sciences, General Social Sciences, Identification (information), 0502 economics and business, Economics, Econometrics, Deterrence theory, 050207 economics, Enforcement, Set (psychology), Construct (philosophy), Social psychology, Adjudication, Panel data, Criminal justice
Abstract

Purpose The purpose of this paper is to examine the interaction of enforcement and adjudication for general deterrence of drunk-driving. The authors present a triangular feedback model between three domains: police, courts and drunk-driving events. The authors’ deductive approach imposes no structural assumptions beyond the core of general deterrence theory. Design/methodology/approach Using a largely untapped data set for California’s 58 counties from 1990 to 2010, the authors estimate a series of heterogeneous panel Granger non-causality tests. This empirically based evidence is re-organized per the proposed triangular feedback model to objectively categorize local criminal justice systems as active, responsive or reactive (with respect to drunk-driving). Findings Our results suggest that state-level analyses obscure useful variations that empirical panel methods can now handle. The authors provide evidence that research based on empirically derived groupings, rather than inductively based preconceptions, is key to understanding enforcement and compliance. The authors provide a less confounded picture of the relationship between drunk-driving enforcement and adjudication. Research limitations/implications Our study addresses one offense for a particular state in the USA. It is an exploratory analysis. This analytical and empirical approach is new. Practical implications Our approach imposes very few a priori assumptions and requires a minimum of data series to be executed. The method can be broadly applied to a range of topics and observational units. Social implications The authors aim to expand identification of local systems’ effectiveness (or not) and mechanisms of for general deterrence of drunk-driving. The offense is one that can be committed easily and unintentionally; it does not presume anomie. The authors address general communities, not anomalies. Knowing how enforcement and compliance operate is essential to an array of behavioral externalities. Originality/value This is a new empirically based approach for analyzing social systems. It is a marriage of new macroeconomic time-series techniques with an old question, most often addressed by microeconomic research. This study uses an underutilized data source to construct a unique panel data set.

Published
2017

16. Delivering coal by road and rail in Britain: the efficiency of the 'silly little bobtailed' coal wagons

Author

Van Vleck, Va Nee L.

Subjects
United Kingdom -- Science and technology policy, Coal industry -- United Kingdom, Railroads -- United Kingdom, Economic history -- United Kingdom, Coal -- Transportation, Economics, History
Abstract

The small railway coal wagon was an early example held up to demonstrate Edwardian Britain's technological stagnation. The small wagons have been blamed for inflated rail freight rates and depressed railway profits. What has been overlooked is that the small wagon was integral to the local coal market. The coal wagon was a substitute for costly distribution and delivery by road transport; although some railway specific costs may have been inflated, beyond the railhead other costs were economized. Seen in the appropriate context the small coal wagon was neither a bad choice nor an oddity.

Published
1997

17. Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

Author

Sherrington, R., Rogaev, E.I., Liang, Y., Rogaeva, E.A., Levesque, G., Ikeda, M., Chi, H., Lin, C., Li, G., Holman, K., Tsuda, T., Mar, L., Foncin, J.-F., Bruni, A.C., Montesi, M.P., Sorbi, S., Rainero, I., Pinessi, L., Nee, L., Chumakov, I., Pollen, D., Brookes, A., Sanseau, P., Polinsky, R.J., Wasco, W., Silva, H.A.R. Da, Haines, J.L., Pericak-Vance, M.A., Tanzi, R.E., Roses, A.D., Fraser, P.E., Rommens, J.M., and St George-Hyslop, P.H.

Subjects
Alzheimer's disease -- Causes of, Mutation (Biology) -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

The locus AD3 which encodes 19 different transcripts is associated with susceptibility to an aggressive early-onset form of Alzheimer's disease (AD). Samples taken from sufferer of this form of AD show five missense mutations in S182, one of the transcripts encoded by AD3 but non-sufferers do not show these mutations. The mutations involve heterozygous nucleotide substitution and may cause early-onset of AD. Studies show that the S182 protein is an integral membrane protein which might be either a receptor or channel protein.

Published
1995

18. Selected abstracts

Author

Corkery, P. P., Leek, B. F., Caulfield, B., Garrett, M., Gormley, J. P., OʼDonnell, P. M., Kennedy, N., Sayers, K., Stokes, E., Bresnihan, B., Fitzgerald, O., McGarvey, M. A., Tonra, M., Hooper, A. C. B., Barry, J., Maurer, B., Hussey, J., Gormley, J., Noble, J. G., Alves-Guerreiro, J., Lowe, A. S., Walsh, D. M., NicNiocaill, B., Harte, M., OʼConnor, W. T., OʼHara, A. M., Orren, A., Moran, A. P., Hardiman, D. A., Lee, T. C., Croke, D. T., Tolan, R., McBennett, S., Warmington, S., McGuire, M., Bradford, A., OʼHare, T., MacDermott, M., Lynch, F., OʼRegan, R. G., McLoughlin, P., Quinn, T., Ryan, J. P., Pickering, M., Campion, D. P., Jones, J. F. X., Ryan, S., McNicholas, W. T., Nolan, P., Doyle, F. J., Rackard, S. M., Beddy, P., Campbell, V. A., Bakhle, Y. S., Bell, C., Usher, C., Chan, L., Keenan, A. K., McQuaid, K. E., Cullen, V. C., Smith, E. M., Kelly, A., Lynch, M. A., Freir, D. B., Holscher, C., Herron, C. E., Pearson, H. A., Curran, B. P., OʼConnor, J. J., Quinn, A., McHale, J., Moriarty, D., OʼConnor, J., Glennon, J. C., Van Vliet, B. J., Long, S. K., Kruse, C., Gallagher, H. C., Bacon, C. L., Boland, B., Griffin, A. M., Preisler, J., OʼBrien, L., Regan, C. M., Hurley, S., Kearney, P. J., Slevin, J., Barry-Kinsella, C., Ryan, C. A., Kllleen, O., Glllan, J., Clarke, T., Matthews, T., Corcoran, D., Dunn, E., Geary, M., OʼHerlihy, C., Keane, D., OʼLeary, M. J., Morrison, J. J., Ryan, E., Gorman, W. A., Bourke, A., Larkin, J., Mayes, C., Jenkins, J., Ryan, M., Lalchandani, S., Sheil, O., Lynch, N., Costigan, C., Murphy, J. F., Bhatia, R., Foran, A., Donohue, V., McParland, P., LaSjaunais, P., Rodesch, G., McGinn, M., McAloon, J., OʼLeary, M., Astbury, K., Harmon, D., Sharkey, A., Gaffney, G., OʼRegan, G., McMahon, C., Murray, D., McDermott, C., Woolhead, E., Gillan, J., Cartmill, J. L., Harper, M. A., Al-Shabibi, N., Hanahoe, M., Wingfield, M., Larkin, J. A. M., Bell, A. H., McClure, B. G., Sweeney, L., Martin, D. H., OʼDonoghue, P., Davoren, A., Lucas, G. F., McKiernan, J., Gallagher, D. M. T., Dunne, K. P., Fulena, O., Sheridan, M., Griffin, E., White, M., Deasy, P., OʼRiordan, M., OʼGorman, C., Mongan, C., McCafferkey, M., Henry, G., McKenna, P., OʼMalley, A., Devaney, D., Kelleghan, P., Mooney, E. E., Gillan, J. E., Fitzpatrick, M., McQuillan, K., Heffron, C., Hodnett, P., Curtain, A., OʼConnor, T. C. F., Connell, T. G., Waldron, D., Gorman, W., Bolger, T., OʼKeefe, M., Murphy, J., Dolan, L. M., Traub, A. I., Slattery, M. M., Curley, A. E., Halliday, H. L., Tubman, T. R. J., Kileen, O., Riadha, H., Russell, J., Philips, R., Regan, C., Ali, I., Coughlan, A. C. J., Turner, M. J., Smith, A., OʼFlanagan, D., Igoe, D., Ryan, F., Forde, D., McArdle, E., Ko, D., Bedford, D., Hegarty, M., Dunlevy, B., Corcoran, R., Holohan, T., Feeney, A., McGee, H., Shannon, W., Condon, M., Hyland, C., Sayers, G., Feely, E., Crowley, D., OʼReilly, D., OʼConnell, T., Cronin, M., Johnson, H., Fitzgeraldi, M., Cafferkey, M., Breslin, A., Bonner, C. J., Foley, B., Fitzgerald, M., Wall, P. G., McNamara, E., Costigan, P., Prendergast, T., Foye, K., Cosgrove, C., Keane, A., Murphy, E., OʼDonnell, J., Quinlan, A., Thornton, L., Roch, E. A., Lyons, R. A., Maddocks, A., Barnes, P., Price, L., McCabe, M., Nash, P., Midha, A., Doyle, Y., Kilgallen, A., Wright, P., Ryan, T., De La Harpe, D., Harkins, V., Brennan, C., OʼConnell, V., Evans, D. S., Mhuircheartaigh, Ni J., OʼDonnell, J. M., Rhatigan, A., Shelley, E., Collins, C., Byrne, M., Murphy, A. W., Plunkett, P. K., Murray, A., Bury, G., Lynam, F., McMahon, G., Greally, T., Kane, D., Veale, D., Reece, R., Busteed, S., Bennett, M. W., Stone, M., Molloy, C., OʼConnell, J., Molloy, M. G., Shanahan, F., Guerin, J., Casey, E., Feighery, C., Lin, F., Jackson, J., Pendleton, A., Wright, G. D., Hughes, A. E., OʼGradaigh, D., Debham, I., Compston, J., McEvoy, A., Murphy, E. P., Salonen, D., Payne, P., Lax, M., Lapp, V., Inman, R., OʼRourke, K., Brennan, D., Harty, J., McCarthy, C., OʼByrne, J., Eustace, S., Chirayath, H., Liggett, N. W., Morgan, M. P., Fitzgerald, D. J., McCarthy, C. J., McCarthy, G. M., Lee, R. Z., Wai, K., Nevin, D., Leary, A. O., Lee, R., Casey, E. B., OʼLeary, A., Breen, D., Tuite, D., McInerney, D., Sim, R., Frederic, A. L., Smith, O., White, B., Murphy, M., Silke, C., OʼKeeffe, E., Fanning, N., Spence, L., Parfrey, N. A., McConnell, J. R., Crockard, A. D., Cairns, A. P., Bell, A. L., Kavanagh, O., Moyes, D. A., Finch, M., Rooney, M., Bell, A., Founas, I., El-Magbri, A., Mooney, S., Kennedy, M., Coughlan, R. J., Ramakrishnan, S. A., Gsel, A., Finnerty, O., Burns, M., Yateman, M., Camaco-Hubner, C., Matthews, C. F., Taggart, A., Fuller, K., Murphy, M. S., Phelan, M., Murphy, T. B., Wynne, F., Quane, K., Daly, M., OʼLeary, J., da Silva, I., Bermingham, N., Gogarty, M., Gallagher, L. P., OʼHara, R., Godson, C., Brady, H., Osman, H., El-Rafie, A., Foley-Nolan, D., Kirwan, P., Corcoran, O., Duffy, T., Drummond, F., Madigan, A., Williams, D., Gallagher, P., Hatton, C., Cunningham, S., FitzGerald, O., Minnock, P., Wylie, E., Egan, D., Mc Cormack, J., Shea, M. O., Evans, D., OʼLorcain, P., Comber, H., Evans, A., Jones, J., Garavan, C., Kelleher, K., Boland, M. C., Healy, R., OʼSullivan, M. B., Burke, M., Mc Donald, P., Smithson, R., Glass, J., Mason, C. A., Mullins, N., Nolan, D., McCormick, P., Coughlan, S., Dooley, S., Kelleher, C. C., Hope, A., Murphy, F., Barry, M., Sixsmith, J., MacFarlane, A., MacLeod, C., McElroy, G., OʼLoan, D., Kennedy, F., Kerr, R. M., Lim, J., Allwright, S. P. A., Bradley, F. L., Barry, J. M. G., Long, J., Parry, J. V., Creagh, D., Perry, I. J., Collins, A., Neilson, S., Colwell, N., OʼHalloran, D., OʼNeill, S., McErlain, S., Okasha, M., Gaffney, B., McCarron, P., Hinchion, R., Drew, C., Gavin, A., Fitzpatrick, D., Campbell, R., Wannamethee, S. G., Shaper, A., Friel, S., Kelleher, C., Kee, F., Atterson, C. C., Wilson, E. A., McConnell, J. M., Wheeler, S. M., Watson, J. D., Rahman, Norashikin N., Sheehan, J., Wall, C., Kelleher, B., OʼBroin, S. D., Mullan, R. N., McKeveney, P. J., Hodges, V. M., Winter, P. C., Maxwell, P., Simpson, D. A., Lappin, T. R. J., Maxwell, A. P., Eustace, J. A., Coresh, J., Kutchey, C., Te, P. L., Gimenez, L. F., Scheel, P. J., Walser, M., McMahon, R. A., Clarkson, M., Martin, F., Brady, H. R., Blake, C., OʼMeara, Y. M., Gupta, S., MacKenzie, H., Doyle, S., Fotheringham, T., Haslam, P., Logan, M. P., Conlon, P., Lee, M., Maderna, P., Cottell, D. C., Mitchell, S., Gulmann, C., Østerby, R., Bangstad, H. J., Rljdberg, S., Dempsey, M., Nathwani, S., Ryan, M. P., McMahon, B., Stenson, C., Murtagh, H., Brown, J. H., Doran, P., McGinty, A., Little, M. A., OʼBrien, E., Owens, P., Holian, J., Mee, F., Walshe, J. J., Omer, S. A., Power, D., Diamond, P., Watson, R. W., Shahsafei, A., Jiang, T., Brenner, B. M., Mackenzie, H. S., Neary, J., Dorman, A., Keoghan, M., Campbell, E., Walshe, J., Little, M., Nee, L., OʼCeallaigh, C., McGlynn, H., Bergin, E., Keane, T., Gormley, G., Watson, A., Atta, M. G., Perl, T. M., Song, X., Healy, E., Leonard, M., Lynch, J., Watson, A. J., Lappin, D., Lappin, D. W. P., Hannan, K., Burne, M., Daniels, F., Rabb, H., McBride, B., Kieran, N., Shortt, C., Codd, M., Murray, F., McCormack, A., Brown, C., Wong, C., Dorman, A. M., Keogan, M., Donohue, J., Farrell, J., Donohoe, J., OʼBroin, S., Balfe, A., Mellotte, G. J., Abraham, K. A., McGorrian, C., Wood, A. E., Neligan, M., Kelly, B. D., Finnegan, P., Cormican, M., Callaghan, J., Crean, J. K. G., Moffitt, T. A., Devlin, H. L., Garrett, P. J., Soosay, A., OʼNeill, D., Counihan, A., Hickey, D., Keogan, M. T., Harvey, K., OʼRiordan, E., Waldek, S., Kalra, P. A., OʼDonoghue, D. J., Foley, R. N., Kelliher, D., Mellotte, G., Giblin, L., Keogh, J. A. B., OʼConnell, M., OʼMeara, A., Breatnach, F., Gillick, J., Tazawa, H., Puri, P., Molloy, E., OʼNeill, A. J., Sheridan-Pereira, M., Fitzpatrick, J. M., Webb, D. W., Watson, R. W. G., Linnane, B., OʼDonnell, C., Clarke, T. A., Martin, C., McKay, M., McBrien, J., Glynn, F., OʼDonovan, C., Hall, W. W., Smith, J., Khair, K., Liesner, R., Hann, I. M., Smith, O. P., Gallagher, S., Mahony, M. J., Hilal, A., Cosgrove, J. F., Monaghan, C., Craig, B., Walsh, K., Duff, D., Slizlok, P. O., Halahakoon, C., McMillan, S., Dalzell, E. E., McCaughan, J., Redmond, A. O. B., DeCaluwe, D., Yoneda, A., Akl, U., Dempsey, E., Farrell, M., Webb, D., Elabbas, A., Fox, G., Gormally, S., Grant, B., Corkey, C. W. B., Nicholson, A., Murphy, A., OʼGrady, P., Barry, O., Stewart, M. C., Alderdice, F., Matthews, T. G., McDonnell, M., McGarvey, C., OʼRegan, M., Chróinín, Ní M., Tormey, P., Ennis, S., Green, A. J., Abbas, S., OʼMarcaigh, A., Conran, M., Crushell, E., Saidi, A., Curran, P., Donoghue, V., King, M. D., Elnazir, B., Leonard, J., Kavanagh, C., Brown, D., Corrigan, N., McCord, B., Quinn, M., OʼConnell, L., Mcdonagh, B., Awan, A., Gill, D., Kakkar, R., Warner, J. A., OʼConnor, C., Herzig, M., Twomey, A., White, M. J., Sweeney, B., Surana, R., Hodgson, A., Rafferty, M., Livingstone, W., Peake, D., Wassemer, E., Whitehouse, W., Abdullah, N., Al-Hassan, A., Oslizlok, P., OʼConnell, N., Balding, J., Livingstone, W. J., Healy, M., Mynett-Johnson, L., McAllister, I., Dick, A. C., Herron, B., Boston, V. E., Callaghan, C. O., Brien, D. O., Walsh, A., Philip, M., McShane, D., Hoey, M. C. V., Sharif, F., McDermott, M., Dillon, M., Drumm, B., Rowland, M., Imrie, C., Kelleher, S., Bourke, B., Iqbal, M., Ziedan, Y., OʼNeill, M., OʼRiordan, S., Basheer, S. M. B., OʼCallaghan, S., Chong, A., Kelly, M., Nicholson, A. J., Cooke, R., Sreenan, C., Fallon, M., Denham, B., Dowding, V., Cussen, G., McManus, V., Hensey, O., Monaghan, H., Basheer, S. N., Quinn, E., Hoey, H. M. C. V., Mohamed, S., Ramesh, R. R., Mayne, P., Tracy, E., Gormally, S. M., Curtis, E., McCallion, N., Watson, R., OʼMahony, O., Keegan, M., Ward, K., Barton, D., Poulton, J., Treacy, E., Honour, J., deCaluwe, D., Chróinín, Ni M., Cosgrove, J., Chaudhry, T. S., Long, N. M., Lynch, B., Lasjaunais, P., McDonald, D. G. M., McMenamin, J. B., Farrell, M. J., Roche, E. F., Menon, A., Buckley, C., Mackey, A., Ohlandieck, K., Das, A., Reilly, D., Killeen, O., Harper, J., Roche, E., Hoey, H., Caird, J., OʼBrien, D., Allcutt, D., Farrington, N., Murphy, J. F. A., Savage, J. M., Sands, A. J., Casey, F. A., Craig, B. G., Dornan, J. C., Johnston, J., Patterson, C., Lynch, C., Mulholland, H. C., Watkins, D. C., Young, I., Cran, G., Boreham, C. A. G., McCallion, W. A., Clements, N. F., Stevenson, M. R., Macpherson, C., Jenkins, L., Thompson, A. J., Shields, M. D., Taylor, R. T., Kerr, R., Hughes, J. L., Stewart, M., Jackson, P., Fitzpatrick, C., Rasheed, M., Colhoun, E., Bailie, A. G., Gray, S., Brown, S., Curley, A., Sweet, D. G., MacMahon, K. J., OʼConnor, C. M., Nichelson, A., Lynch, N. E., Finch, D., Foley, M., Scallan, E., Dillon, B., Lyons, S., OʼLoughlin, R., Ward, M., Nally, R., Harkin, A., Kelly, J. P., Leonard, B. E., Magee, P., Connor, T. J., Shen, Y., McCullough, G. R., McDonough, S. M., Niocaill, Nic B., Cramp, A. F. L., Hynes, M., Corkery, P., Carey, M., McGarrigle, D., Higgins, S., Murray, H., Moran, C. J., Dennedy, M. C., Brosnan, J., Morris, L., Sheppard, B. L., Black, A., Wilkins, B., Folan-Curran, J., Skelton, K., Owens, M., Nemeroff, C., Houlihan, D., OʼKeeffe, C., Nolan, N., McCormick, P. A., Baird, A. W., Raducan, I., Corcoran, P., Brennan, R., Molloy, P., Friel, A., Maher, M., Glennon, M., Smith, T., Nolan, A., Houghton, J. A., Carroll, O., Colleran, S., OʼCuinn, G., Snow, H. M., OʼRegan, D., Markos, H. F., Pollock, K., Cannon, D. M., McBean, G., OʼRiordan, A., Quinlan, L. R., Kane, M. T., Higglns, B. D., Moriarty, D. M., Fitzgerald, D., Katkada, A., Canny, G., MacMathuna, P., OʼDonoghue, D., OʼDonovan, M. M., Schuur, A. G., Murphy, K. J., Foley, A. G., ten Bruggencate, S. J. M., and Ireland, L.

Published
2000
Full Text
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19. Transmission and age-at-onset patterns in familial Alzheimer's disease: evidence for heterogeneity

Author

Farrer, L.A., Myers, R.H., Cupples, L.A., St. George-Hyslop, P.H., Bird, T.D., Rossor, M.N., Mullan, M.J., Polinsky, R., Nee, L., Heston, L., Van Broeckhoven, C., Martin, J-J., Crapper-McLachlan, D., and Growdon, J.H.

Subjects
Alzheimer's disease -- Genetic aspects, Health, Psychology and mental health
Abstract

The majority of cases of Alzheimer's disease (AD) occur sporadically. However, there are some families in which Alzheimer's disease seems to be passed from generation to generation as an inherited trait. Although these cases of familial Alzheimer's disease (FAD) constitute only a small minority, they may provide important clues to the development of the disease in general. Furthermore, there has been some suggestion that even in the sporadic cases which are not, strictly speaking, inherited, there may still be a strong contribution of an individual's genetic makeup to the ultimate development of AD. A study was undertaken to explore in greater detail the mode of inheritance of FAD. Seventy affected family groups were studied, consisting of 541 affected and 1,066 unaffected offspring of parents with AD. Such studies are complicated by the fact that unaffected offspring may simply not be old enough to develop the symptoms of AD, and any investigation of the inheritance of the disorder must use statistical methods to take this possibility into account. Overall, a rate of Alzheimer's disease of 64 percent (by age 87) was observed for the children of parents with FAD. This figure is slightly higher than the 50 percent which would be expected if the disorder were randomly passed from generation to generation as a dominant trait. However, when the families were grouped by average age of onset, a different pattern emerged. By defining 'early-onset' AD as disease symptoms beginning before the age of 58, it was found that the statistics of FAD differed for early- and late-onset disease. In families with early-onset FAD, the rate among offspring of affected parents was 53 percent, very close to the theoretically expected 50 percent. In contrast, among the late-onset families, in which disease symptoms first appeared after the age of 58, the rate of disease among offspring of affected parents was 86 percent, significantly higher. These observations suggest that the early-onset disease may be inherited as a simple dominant trait, while the late-onset disease may have a more complicated mode of inheritance which is not yet understood. (Consumer Summary produced by Reliance Medical Information, Inc.)

Published
1990

24. Molecular Genetic Strategies in Familial Alzheimer’s Disease: Theoretical and Practical Considerations

Author

St George-Hyslop, P. H., Farrer, L., Haines, J., Myers, R., Polinsky, R., Nee, L., Bruni, A., Scorbi, S., Piacentini, S., Amaducci, L., Foncin, J.-F., Feldman, R. G., Frommelt, P., Watkins, P., Tanzi, R., Aalbo, J., Growdon, J., Drachman, D., Pollen, D., Conneally, P. M., Gusella, J., Christen, Yves, editor, Sinet, Pierre Marie, editor, and Lamour, Yvon, editor

Published
1988
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25. Paradoxal presence of spare A2A receptors in patients with coronary artery disease with positive exercise stress test

Author

Mottola, G., Bonello, L., Kipson, N., Fromonot, J., Condo, J., Boussuges, A., Bruzzese, L., Nee, L., Kerbaul, F., Gariboldi, V., Franceschi, F., Fenouillet, E., Paganelli, F., Guieu, R., Jean RUF, Aix Marseille Université (AMU), Dysoxie, suractivité : aspects cellulaires et intégratifs thérapeutiques (DS-ACI / UMR MD2), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Vascular research center of Marseille (VRCM), Institut National de la Santé et de la Recherche Médicale (INSERM)-Aix Marseille Université (AMU), Physiopathologie de l'Endothelium, Institut National de la Santé et de la Recherche Médicale (INSERM)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Aix Marseille Université (AMU), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM), DIGNAT-GEORGE, Françoise, and Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)

Subjects
[SDV] Life Sciences [q-bio], [SDV]Life Sciences [q-bio], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2016

26. Pass GO and collect $610: modified Monopoly for teaching inequality

Author

Va Nee L. Van Vleck and Kevin W. Capehart

Subjects
Sociology and Political Science, Inequality, media_common.quotation_subject, 05 social sciences, 050401 social sciences methods, Survey result, 06 humanities and the arts, Education, 0504 sociology, Work (electrical), Luck, Economic inequality, 060402 drama & theater, Perception, Inheritance, Psychology, Monopoly, General Economics, Econometrics and Finance, Social psychology, 0604 arts, media_common
Abstract

Modified versions of the board game Monopoly have been used to teach inequality. This paper reviews modifications suggested in the pedagogical literature and then reports survey-based results on whether playing a modified version of the game affected students' objective perceptions or subjective attitudes towards inequality. Our survey results suggest that, compared to a group of students who received only a traditional lecture on inequality statistics, students who played the modified Monopoly game saw larger improvements in their objective perceptions of the actual extent of income and wealth inequality and, also, bigger changes in their subjective attitudes about the importance of inheritance, luck, and hard work to real-world success. Yet, attitudes were not dramatically affected by playing the game and misperceptions about basic inequality statistics remained, so higher impact approaches to teaching inequality are still needed.

Published
2018

27. Worldwide distribution for the PSEN1 Met46Leu founder mutation: a large variability for a founder mutation

Author

BRUNI A. M., BERNARDI R., COLAO R., RUBINO E., SMIRNE N., FRANGIPANE F., TERNI B., CURCIO S. A. M., MIRABELLI M., CLODOMIRO A., DiLORENZO R., MALETTA R., ANFOSSI M., GALLO M., GERACITANO S., TOMAINO C., MURACA M. G., LEOTTA A., LIO S. G., PINESSI L., RAINERO I., SORBI S., NEE L., MILAN G., PAPPATA' S., ABBAMONDI N., FORLONI G., S.t. GEORGE HYSLOP P., ROGAEVA E., BUGIANI O., GIACCONE G., FONCIN J. F., SPILLANTINI M. G., PUCCIO G. F., POSTIGLIONE, ALFREDO, Bruni, A. M., Bernardi, R., Colao, R., Rubino, E., Smirne, N., Frangipane, F., Terni, B., Curcio, S. A. M., Mirabelli, M., Clodomiro, A., Dilorenzo, R., Maletta, R., Anfossi, M., Gallo, M., Geracitano, S., Tomaino, C., Muraca, M. G., Leotta, A., Lio, S. G., Pinessi, L., Rainero, I., Sorbi, S., Nee, L., Milan, G., Pappata', S., Postiglione, Alfredo, Abbamondi, N., Forloni, G., S. t. GEORGE HYSLOP, P., Rogaeva, E., Bugiani, O., Giaccone, G., Foncin, J. F., Spillantini, M. G., and Puccio, G. F.

Subjects
Alzheimer, genetica, dementia
Abstract

OBJECTIVE: Large kindreds segregating familial Alzheimer disease (FAD) offer the opportunity of studying clinical variability as observed for presenilin 1 (PSEN1) mutations. Two early-onset FAD (EOFAD) Calabrian families with PSEN1 Met146Leu (ATG/CTG) mutation constitute a unique population descending from a remote common ancestor. Recently, several other EOFAD families with the same mutation have been described worldwide. METHODS: We searched for a common founder of the PSEN1 Met146Leu mutation in families with different geographic origins by genealogic and molecular analyses. We also investigated the phenotypic variability at onset in a group of 50 patients (mean age at onset 40.0 +/- 4.8 years) by clinical, neuropsychological, and molecular methodologies. RESULTS: EOFAD Met146Leu families from around the world resulted to be related and constitute a single kindred originating from Southern Italy before the 17th century. Phenotypic variability at onset is broad: 4 different clinical presentations may be recognized, 2 classic for AD (memory deficits and spatial and temporal disorientation), whereas the others are expressions of frontal impairment. The apathetic and dysexecutive subgroups could be related to orbital-medial prefrontal cortex and dorsolateral prefrontal cortex dysfunction. CONCLUSIONS: Genealogic and molecular findings provided evidence that the PSEN1 Met146Leu families from around the world analyzed in this study are related and represent a single kindred originating from Southern Italy. The marked phenotypic variability might reflect early involvement by the pathologic process of different cortical areas. Although the clinical phenotype is quite variable, the neuropathologic and biochemical characteristics of the lesions account for neurodegenerative processes unmistakably of Alzheimer nature.

Published
2010

28. In Defense (Again) of 'Silly Little Bobtailed' Coal Wagons: Reply to Peter Scott

Author

Va Nee L. Van Vleck

Subjects
Counterfactual thinking, Economics and Econometrics, History, Total cost, business.industry, Economics, Econometrics and Finance (miscellaneous), Commodity, Haulage, Microeconomics, Property rights, Law, Economics, Coal, business, Externality, Sunk costs
Abstract

Peter Scott defends the classic Veblen-Kindleberger hypothesis, that sunk costs imposed inefficiencies in the British rail industry into the twentieth century, against the alternative interpretation presented in my article. Scott introduces more refined technical details of the economies of coal haulage to estimate that substantial economies-now purportedly 56 percent of operating costs-could have been reaped if only British coal had been transported in "larger" wagons; these operating economies went unrealized because of sunk costs in smallish wagons and infrastructure. That sunk costs mattered at all, in his view, was the regrettable result of fragmented ownership between the railways and the heterogenous wagonowners. Scott's comment defimitely introduces an improved basis for the estimation of operating costs. But as he acknowledges, his new estimates for rail haulage are not what lead him to such radically different conclusions.1 Instead it is two other new assumptions which generate the large cost savings he ascribes to large wagons: that the externalities were considerable and that only an institutional rearrangement of property rights would make the internalization possible. I believe that Scott overstates the magnitude of the potential benefit; moreover, his counterfactuals are quite removed from both the counterfactual I investigated and the actual history of the coal wagon. In this reply I will address Scott's misunderstanding of my operating-cost calculations, and the problems inherent in his two key assumptions, of large unrealized gains and of a radically different institutional setting. On the matter of calculating the savings to be anticipated from a system of larger wagons, Scott expresses dismay at my "rather indirect method" and "questionable assumptions." Yet surely a first approximation is to be preferred to the unquantified assertions in the earlier literature.2 At any rate, my intervention has spurred Scott to offer information that refines the engineering details of the calculation, which I accept as an improvement. He believes that I misconstrued the nature of the British rail traffic in weighting my estimates of operational savings by the proportion of coal and minerals in freight as a whole.3 It is puzzling that Scott interprets "weight[ing] the calculated operational savings by the share of traffic volume represented by coal and minerals" as implying that freight traffic was "mixed indiscriminately." Most coal was certainly transported in what are now called "unit trains"-trains loaded with a single commodity, usually coal, other minerals, or grain-and thus was not typically mixed in with general freight. Railway costs were accumulated on a traffic-wide basis, but it was on the coal portion of the traffic that the railways of the day expected to reduce operating costs. My method ofweighting the total cost savings by coal's share in traffic most directly simulates this expectation. To generalize, as Scott does, the operational savingsfrom larger coal wagons to the whole of railway operations when they were not mixed in amid other freight introduces a strong upward bias. If Scott's projected overall savings of 30 to 35 percent is weighted by the proportion of coal in total railway

Published
1999

29. Delivering Coal by Road and Rail in Britain: The Efficiency of the 'Silly Little Bobtailed' Coal Wagons

Author

Va Nee L. Van Vleck

Subjects
Road transport, Economics and Econometrics, History, Railhead, business.industry, Natural resource economics, Economics, Econometrics and Finance (miscellaneous), Distribution (economics), Coal, Context (language use), business
Abstract

The small railway coal wagon was an early example held up to demonstrate Edwardian Britain’s technological stagnation. The small wagons have been blamed for inflated rail freight rates and depressed railway profits. What has been overlooked is that the small wagon was integral to the local coal market. The coal wagon was a substitute for costly distribution and delivery by road transport; although some railway specific costs may have been inflated, beyond the railhead other costs were economized. Seen in the appropriate context the small coal wagon was neither a bad choice nor an oddity.

Published
1997

32. Alert eyes and DWIs: an indirect evaluation of a DWI witness reward program in Stockton, CA

Author

Garland L Brinkley and Van Nee L Van Vleck

Subjects
medicine.medical_specialty, Engineering, Cost-Benefit Analysis, Poison control, Human Factors and Ergonomics, Seemingly unrelated regressions, Computer security, computer.software_genre, Suicide prevention, Occupational safety and health, California, Grassroots, Law Enforcement, Reward, Injury prevention, medicine, Humans, Safety, Risk, Reliability and Quality, Psychiatry, health care economics and organizations, business.industry, Social cost, Public Health, Environmental and Occupational Health, Accidents, Traffic, Community Participation, Human factors and ergonomics, Cross-Sectional Studies, business, computer, Alcoholic Intoxication, Confidentiality
Abstract

We evaluate a "grassroots" anonymous reward program targeting drunken driving in Stockton, CA. The time-series cross-sectional data covers 19 years for Stockton and six other California cities. Exploiting interrupted time-series regression, Zellner's seemingly unrelated regression (SUR) framework, and bootstrapped standard errors, we test for an impact of this program on alcohol-related injury or fatality accidents, the proportion of all accidents involving alcohol, and the number of DWI arrests. In its first decade, the citizen reward program appears to have averted some 275 alcohol-related accidents for social cost savings of between $21,000 and $5.6 million. Further, possibly 4495 arrests were precluded, saving some $1-3 million in arrest-related costs. Incentivized public monitoring of driving-after-drinking may be an effective drunken driving abatement program though our exploratory findings need further confirmation.

Published
2008

33. Molecular Genetic Strategies in Familial Alzheimer’s Disease: Theoretical and Practical Considerations

Author

St George-Hyslop, P. H., primary, Farrer, L., additional, Haines, J., additional, Myers, R., additional, Polinsky, R., additional, Nee, L., additional, Bruni, A., additional, Scorbi, S., additional, Piacentini, S., additional, Amaducci, L., additional, Foncin, J.-F., additional, Feldman, R. G., additional, Frommelt, P., additional, Watkins, P., additional, Tanzi, R., additional, Aalbo, J., additional, Growdon, J., additional, Drachman, D., additional, Pollen, D., additional, Conneally, P. M., additional, and Gusella, J., additional

Published
1988
Full Text
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34. DNA Markers in Familial Alzheimer’s Disease

Author

George-Hyslop, P. H. St., primary, Tanzi, R., additional, Hobbs, W., additional, Gibbons, K., additional, Gusella, J. F., additional, Nee, L., additional, Polinsky, R., additional, Haines, J., additional, and Conneally, P. M., additional

Published
1986
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37. Reassessing Technological Backwardness: Absolving The 'Silly Little Bobtailed' Coal Car

Author

Va Nee L. Van Vleck

Subjects
Economics and Econometrics, History, Emerging technologies, Veblen good, Argument, business.industry, Economics, Econometrics and Finance (miscellaneous), Shackle, Economics, Coal, Neoclassical economics, business, Backwardness
Abstract

Rarely are judgements of entrepreneurial failure and technological backwardness rendered as harshly as when they are rendered upon Britain in the early 1900s.1 The use of old technologies in manufacturing and transportation are claimed to have locked Britain onto a lower growth path than would have followed if new technologies had been used instead. Technological backwardness, it has been said, was a shackle and Britain lagged behind because of it.2Thorstein Veblen made this argument and marshalled a specific example: “silly little bobtailed carriages [railway wagons].”3In my dissertation I argue that the small coal wagons were not technologically backward, as Veblen and others since have claimed.

Published
1995

38. Pass GO and collect $610: modified Monopolyfor teaching inequality

Author

Capehart, Kevin W. and Vleck, Va Nee L. Van

Abstract

Modified versions of the board game Monopolyhave been used to teach inequality. This paper reviews modifications suggested in the pedagogical literature and then reports survey-based results on whether playing a modified version of the game affected students' objective perceptions or subjective attitudes towards inequality. Our survey results suggest that, compared to a group of students who received only a traditional lecture on inequality statistics, students who played the modified Monopolygame saw larger improvements in their objective perceptions of the actual extent of income and wealth inequality and, also, bigger changes in their subjective attitudes about the importance of inheritance, luck, and hard work to real-world success. Yet, attitudes were not dramatically affected by playing the game and misperceptions about basic inequality statistics remained, so higher impact approaches to teaching inequality are still needed.

Published
2018
Full Text
View/download PDF

39. Latent class subtyping of attention-deficit/hyperactivity disorder and comorbid conditions

Author

Acosta, M. T., Castellanos, F. X., Bolton, Kelly L., Balog, J., Eagen, P., Nee, L., Janet, Jones, Luis Guillermo, Palacio, Sarampote, C., Russell, H. F., Berg, kate, Arcos-Burgos, Mauricio, Muenke, Maximilian, Acosta, M. T., Castellanos, F. X., Bolton, Kelly L., Balog, J., Eagen, P., Nee, L., Janet, Jones, Luis Guillermo, Palacio, Sarampote, C., Russell, H. F., Berg, kate, Arcos-Burgos, Mauricio, and Muenke, Maximilian

Abstract

Objective: Genetic studies of attention-deficit/hyperactivity disorder (ADHD) generally use discrete DSM-IV subtypes to define diagnostic status. To improve correspondence between phenotypic variance and putative susceptibility genes, multivariate classif

Published
2008

40. Analysis of mutations in two homologous genes causing familial Alzheimer's disease

Author

Stgeorgehyslop, Ph, Sherrington, R, Rogaev, E, Tsuda, T, Ikeda, M, Pollen, D, Roses, A, Pericakvance, M, Nee, L, Polinsky, R, Rainero, Innocenzo, Pinessi, Lorenzo, Vaula, G, Sorbi, S, Amaducci, L, Bruni, A, Montesi, M, Foncin, Jf, Abe, K, Aoki, M, Shoji, M, Hirai, S, Watanabe, M, and Lannfelt, L.

Subjects
familial Alzheimer's disease, genetics
Published
1996

41. Cloning of a novel gene bearing missense mutations in early-onset Alzheimer's disease

Author

Sherrington, R, Rogaev, Ei, Liang, Y, Rogaeva, Ea, Levesque, G, Ikeda, M, Chi, H, Lin, C, Li, G, Holman, K, Tsuda, T, Mar, L, Foncin, Jf, Bruni, Ac, Montesi, Mp, Sorbi, S, Rainero, Innocenzo, Pinessi, Lorenzo, Nee, L, Chumak, I, Pollen, D, Brookes, A, Sanseau, P, Polinski, Rj, and Wasco

Subjects
Alzheimer disease, gene mutation
Published
1995

44. Worldwide distribution of PSEN1 Met146Leu mutation: A large variability for a founder mutation

Author

Bruni, A. C., primary, Bernardi, L., additional, Colao, R., additional, Rubino, E., additional, Smirne, N., additional, Frangipane, F., additional, Terni, B., additional, Curcio, S.A.M., additional, Mirabelli, M., additional, Clodomiro, A., additional, Di Lorenzo, R., additional, Maletta, R., additional, Anfossi, M., additional, Gallo, M., additional, Geracitano, S., additional, Tomaino, C., additional, Muraca, M. G., additional, Leotta, A., additional, Lio, S. G., additional, Pinessi, L., additional, Rainero, I., additional, Sorbi, S., additional, Nee, L., additional, Milan, G., additional, Pappata, S., additional, Postiglione, A., additional, Abbamondi, N., additional, Forloni, G., additional, St. George Hyslop, P., additional, Rogaeva, E., additional, Bugiani, O., additional, Giaccone, G., additional, Foncin, J. F., additional, Spillantini, M. G., additional, and Puccio, G., additional

Published
2010
Full Text
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45. Selected abstracts

Author

Corkery, P. P., Leek, B. F., Caulfield, B., Garrett, M., Gormley, J. P., O’Donnell, P. M., Kennedy, N., Sayers, K., Stokes, E., Bresnihan, B., Fitzgerald, O., McGarvey, M. A., Tonra, M., Hooper, A. C. B., Barry, J., Maurer, B., Hussey, J., Gormley, J., Noble, J. G., Alves-Guerreiro, J., Lowe, A. S., Walsh, D. M., NicNiocaill, B., Harte, M., O’Connor, W. T., O’Hara, A. M., Orren, A., Moran, A. P., Hardiman, D. A., Lee, T. C., Croke, D. T., Tolan, R., McBennett, S., Warmington, S., McGuire, M., Bradford, A., O’Hare, T., MacDermott, M., Lynch, F., O’Regan, R. G., McLoughlin, P., Quinn, T., Ryan, J. P., Pickering, M., Campion, D. P., Jones, J. F. X., Ryan, S., McNicholas, W. T., Nolan, P., Doyle, F. J., Rackard, S. M., Beddy, P., Campbell, V. A., Bakhle, Y. S., Bell, C., Usher, C., Chan, L., Keenan, A. K., McQuaid, K. E., Cullen, V. C., Smith, E. M., Kelly, A., Lynch, M. A., Freir, D. B., Holscher, C., Herron, C. E., Pearson, H. A., Curran, B. P., O’Connor, J. J., Quinn, A., McHale, J., Moriarty, D., O’Connor, J., Glennon, J. C., Van Vliet, B. J., Long, S. K., Kruse, C., Gallagher, H. C., Bacon, C. L., Boland, B., Griffin, A. M., Preisler, J., O’Brien, L., Regan, C. M., Hurley, S., Kearney, P. J., Slevin, J., Barry-Kinsella, C., Ryan, C. A., Kllleen, O., Glllan, J., Clarke, T., Matthews, T., Corcoran, D., Dunn, E., Geary, M., O’Herlihy, C., Keane, D., Slattery, M. M., O’Leary, M. J., Morrison, J. J., Ryan, E., Gorman, W. A., Bourke, A., Larkin, J., Mayes, C., Jenkins, J., Ryan, M., Lalchandani, S., Sheil, O., Lynch, N., Costigan, C., Murphy, J. F., Bhatia, R., Foran, A., Donohue, V., McParland, P., LaSjaunais, P., Rodesch, G., McGinn, M., McAloon, J., O’Leary, M., Astbury, K., Harmon, D., Sharkey, A., Gaffney, G., O’Regan, G., McMahon, C., Murray, D., McDermott, C., Woolhead, E., Gillan, J., Cartmill, J. L., Harper, M. A., Al-Shabibi, N., Hanahoe, M., Wingfield, M., Larkin, J. A. M., Bell, A. H., McClure, B. G., Sweeney, L., Martin, D. H., O’Donoghue, P., Davoren, A., Lucas, G. F., McKiernan, J., Gallagher, D. M. T., Dunne, K. P., Fulena, O., Sheridan, M., Griffin, E., White, M., Deasy, P., O’Riordan, M., O’Gorman, C., Mongan, C., McCafferkey, M., Henry, G., McKenna, P., O’Malley, A., Devaney, D., Kelleghan, P., Mooney, E. E., Gillan, J. E., Fitzpatrick, M., McQuillan, K., Heffron, C., Hodnett, P., Curtain, A., O’Connor, T. C. F., Connell, T. G., Waldron, D., Gorman, W., Bolger, T., O’Keefe, M., Murphy, J., Dolan, L. M., Traub, A. I., Slattery, M. M., O’Leary, M. J., Curley, A. E., Halliday, H. L., Tubman, T. R. J., Kileen, O., Riadha, H., Russell, J., Philips, R., Regan, C., Ali, I., Coughlan, A. C. J., Turner, M. J., Smith, A., O’Flanagan, D., Igoe, D., Ryan, F., Forde, D., McArdle, E., Ko, D., Bedford, D., Hegarty, M., Dunlevy, B., Corcoran, R., Holohan, T., Feeney, A., McGee, H., Shannon, W., Condon, M., Hyland, C., Sayers, G., Feely, E., Crowley, D., O’Reilly, D., O’Connell, T., Cronin, M., Johnson, H., Fitzgeraldi, M., Cafferkey, M., Breslin, A., Bonner, C. J., Foley, B., Fitzgerald, M., Wall, P. G., McNamara, E., Costigan, P., Prendergast, T., Foye, K., Cosgrove, C., Keane, A., Murphy, E., O’Donnell, J., Quinlan, A., Thornton, L., Roch, E. A., Lyons, R. A., Maddocks, A., Barnes, P., Price, L., McCabe, M., Nash, P., Midha, A., Doyle, Y., Kilgallen, A., Wright, P., Ryan, T., De La Harpe, D., Harkins, V., Brennan, C., O’Connell, V., Evans, D. S., Ni Mhuircheartaigh, J., O’Donnell, J. M., Rhatigan, A., Shelley, E., Collins, C., Byrne, M., Murphy, A. W., Plunkett, P. K., Murray, A., Bury, G., Lynam, F., McMahon, G., Greally, T., Kane, D., Veale, D., Reece, R., Busteed, S., Bennett, M. W., Stone, M., Molloy, C., O’Connell, J., Molloy, M. G., Shanahan, F., Guerin, J., Casey, E., Feighery, C., Lin, F., Jackson, J., Pendleton, A., Wright, G. D., Hughes, A. E., O’Gradaigh, D., Debham, I., Compston, J., McEvoy, A., Murphy, E. P., Salonen, D., Payne, P., Lax, M., Lapp, V., Inman, R., O’Rourke, K., Brennan, D., Harty, J., McCarthy, C., O’Byrne, J., Eustace, S., Chirayath, H., Liggett, N. W., Morgan, M. P., Fitzgerald, D. J., McCarthy, C. J., McCarthy, G. M., Lee, R. Z., Wai, K., Nevin, D., Leary, A. O., Lee, R., Leary, A. O., Casey, E. B., Leary, A. O., O’Leary, A., Breen, D., Tuite, D., McInerney, D., Sim, R., Frederic, A. L., Smith, O., White, B., Murphy, M., Silke, C., O’Keeffe, E., Fanning, N., Spence, L., Parfrey, N. A., McConnell, J. R., Crockard, A. D., Cairns, A. P., Bell, A. L., Kavanagh, O., Moyes, D. A., Finch, M., Rooney, M., Bell, A., Founas, I., El-Magbri, A., Mooney, S., Kennedy, M., Coughlan, R. J., Ramakrishnan, S. A., Gsel, A., Finnerty, O., Burns, M., Yateman, M., Camaco-Hubner, C., Matthews, C. F., Taggart, A., Fuller, K., Murphy, M. S., Phelan, M., Murphy, T. B., Wynne, F., Quane, K., Daly, M., O’Leary, J., da Silva, I., Bermingham, N., Gogarty, M., Gallagher, L. P., O’Hara, R., Godson, C., Brady, H., Osman, H., El-Rafie, A., Foley-Nolan, D., Kirwan, P., Corcoran, O., Duffy, T., Drummond, F., Madigan, A., Williams, D., Gallagher, P., Hatton, C., Cunningham, S., FitzGerald, O., Minnock, P., Wylie, E., Egan, D., Mc Cormack, J., Shea, M. O., Evans, D., O’Lorcain, P., Comber, H., Evans, A., Jones, J., Garavan, C., Kelleher, K., Boland, M. C., Healy, R., O’Sullivan, M. B., Burke, M., Mc Donald, P., Smithson, R., Glass, J., Mason, C. A., Mullins, N., Nolan, D., McCormick, P., Coughlan, S., Dooley, S., Kelleher, C. C., Hope, A., Murphy, F., Barry, M., Sixsmith, J., MacFarlane, A., MacLeod, C., McElroy, G., O’Loan, D., Kennedy, F., Kerr, R. M., Lim, J., Allwright, S. P. A., Bradley, F. L., Barry, J. 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46. Productivity, Innovation and Economic Performance. Edited by Ray Barrell, Geoff Mason, and Mary O'Mahony. Cambridge: Cambridge University Press, 2000. Pp. vii, 289. $74.95

Author

Va Nee L. Van Vleck

Subjects
Coherence (units of measurement), Economics and Econometrics, History, business.industry, Economics, Econometrics and Finance (miscellaneous), Economic history, Economics, business, Tertiary sector of the economy, Productivity, Capital market
Abstract

Ray Barrell, Geoff Mason, and Mary O'Mahony have compiled a volume that includes a smattering of economic history, the service sector, the IT revolution, international competitiveness, capital markets, R&D, and education. The connections between these topics are surprisingly coherent from one to the next, although the coherence of the whole is mainly implied. In 11 chapters by 23 contributors, this trim volume examines the complex interaction of innovation and productivity in Britain in the last 20-plus years.

Published
2001

47. Genetic linkage studies suggest that Alzheimer's disease is not a single homogeneous disorder

Author

St George Hyslop, P. H., Haines, J. L., Farrer, L. A., Polinsky, R., Van Broeckhoven, C., Goate, A., Crapper McLachlan, D. R., Orr, H., Bruni, A. C., Sorbi††, S., Rainero, I., Foncin, J. F., Pollen, D., Cantu, J. M., Tupler, Rossella, Voskresenskaya, N., Mayeux, R., Growdon, J., Fried, V. A., Myers, R. H., Nee, L., Backhovens, H., Martin, J. J., Rossor, M., Owen, M. J., Mullan, M., Percy, M. E., Karlinsky, H., Rich, S., Heston, L., Montesi, M., Mortilla, M., Nacmias, N., Gusella, J. F., and Hardy, J. A.

Subjects
linkage analysis, familial Alzheimer's disease, genetic heterogeneity
Published
1990

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