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1. Continuous nucleocytoplasmic shuttling underlies transcriptional activation of PPARgamma by FABP4

Author

Ayers, Stephen D., Nedrow, Katherine L., Gillilan, Richard E., and Noy, Noa

Subjects
Cytoplasm -- Chemical properties, DNA binding proteins -- Structure, DNA binding proteins -- Chemical properties, Genetic transcription -- Research, Biological sciences, Chemistry
Abstract

The structural features which underlie the nucleocytoplasmic transport of FABP4 is explained. FABP4 delivers specific ligands from the cytosol to the nuclesr receptor PPARgamma in the nucleus, thereby facilitating the ligation and enhancing the transcriptional activity of the receptor.

Published
2007

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