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1. Tratado de Cirurgia Torácica

Author

Sardenberg, Rodrigo Afonso da Silva, primary, Oliveira, Acácia Maria Lima de, additional, Rubin, Adalberto Sperb, additional, Lago, Ademilson Pedroza, additional, Neder, Alberto, additional, Mariani, Alessandro Wasum, additional, Marra, Alexandre Rodrigues, additional, Argueta, Alonso José Oviedo, additional, Gimenes, Ana Cristina, additional, Castro, Ana Cristina P., additional, Santos, Ana Paula, additional, Albuquerque, André, additional, Hovnanian, André, additional, Dias, André Roncon, additional, Carvalho, André Ywata de, additional, Pereira, Andrea Arvai, additional, Sala, Andréa Diogo, additional, Soares, Andrey, additional, Fernandes, Angelo, additional, Avertano, Antonio Bomfim Marçal, additional, Buzaid, Antonio Carlos, additional, Marttos, Antonio, additional, Santos Júnior, Antonio Oliveira dos, additional, Segurado, Arthur, additional, Pereira, Artur Eugênio de Azevedo, additional, Katz, Artur, additional, Ishy, Augusto, additional, Bryant, Ayesha S., additional, Pereira, Bruno Monteiro Tavares, additional, Saba, Bruno Sampaio, additional, Nunes, Carina Silveira Mariano, additional, Buchpiguel, Carlos Alberto, additional, Teixeira, Carlos Henrique Andrade, additional, Yen, Cheng Tzu, additional, Colovos, Christos, additional, Simões, Cláudia Marquez, additional, Costa, Clèdicyon Eloy da, additional, Deheinzelin, Daniel, additional, Sugarbaker, David J., additional, Rivas, Diego González, additional, Pontes, Edgard Porto de Oliveira, additional, Hirano, Elcio Shiyoiti, additional, Negri, Elnara Márcia, additional, Donizetti, Enis, additional, Stanzani, Fabiana, additional, Jatene, Fábio Biscegli, additional, Antoniali, Fernando, additional, Abrão, Fernando Conrado, additional, Oliveira, Fernando Nunes Galvão de, additional, Westphal, Fernando, additional, Zampieri, Fernando Godinho, additional, Akar, Firas Abu, additional, Castro Junior, Gilberto de, additional, Soares, Gregório Pinheiro, additional, Haddad, Guilherme Saraiva, additional, Mendonça Filho, Guilherme Vieira de, additional, Ribeiro, Gustavo Calado de Aguiar, additional, Fortunato, Gustavo, additional, Fraga, Gustavo Pereira, additional, Olivetti, Gustavo Tadeu, additional, Minamoto, Hélio, additional, Asamura, Hisao, additional, Abreu, Igor Renato Louro Bruno de, additional, Caires, Inacelli Queiroz de Souza, additional, Medeiros, Israel Lopes de, additional, Deslauriers, Jean, additional, Pereira, João Carlos das Neves, additional, Breda, João Roberto, additional, Valverde, João, additional, Cooper, Joel David, additional, Camargo, José de Jesus Peixoto, additional, Parreira, José Gustavo, additional, Trindade, Juliana Mol, additional, Franceschini, Juliana P., additional, Turaça, Karina, additional, Mattox, Kenneth, additional, Castro, Lara Reinel de, additional, Bittencourt, Lia Rita Azeredo, additional, Kowalski, Luis Paulo, additional, Losso, Luiz Carlos, additional, Reis, Luiz Fernando, additional, Ximenes Neto, Manoel, additional, DaSilva, Marcelo C., additional, Sampaio, Marcelo Ferraz, additional, Oliveira, Márcia Gonçalves de, additional, Zielinski, Marcin, additional, Samano, Marcos Naoyuki, additional, Lourenço, Maria Teresa D. P. Cruz, additional, Laloni, Mariana Tosello, additional, Moscardi, Mariana F. Jucá, additional, Ferguson, Mark K., additional, Coelho, Marlos de Souza, additional, Lourenço, Matheus P. C. Gomes, additional, Lopes, Mauricio Marson, additional, Madani, Michael, additional, Dias, Olívia Meira, additional, Ugalde, Paula, additional, Cardoso, Paulo Francisco Guerreiro, additional, Hoff, Paulo Marcelo Gehm, additional, Fernandes, Paulo Manuel Pêgo, additional, Adusumilli, Prasad S., additional, Mendes, Pedro Vitale, additional, Gurung, Puncho, additional, Lima, Rafael Caires Alvino de, additional, Rami-Porta, Ramón, additional, Moreira, Raphael Brandão, additional, Peixoto, Renata DAlpino, additional, Ferrarotto, Renata, additional, Younes, Riad Naim, additional, Fogaroli, Ricardo Cesar, additional, Bammann, Ricardo Helbert, additional, Terra, Ricardo Mingarini, additional, Santos, Ricardo Sales dos, additional, Cerfolio, Robert James, additional, Sardenberg, Rodrigo Afonso da Silva, additional, Guedes, Rodrigo Antonio Vieira, additional, Brock, Roger Schmidt, additional, Haddad, Rui, additional, Swanson, Scott James, additional, Wightman, Sean C., additional, Simon, Sérgio Daniel, additional, Kremer, Sérgio, additional, Keshavjee, Shaf, additional, Meireles, Sibele Inácio, additional, Farezin, Sonia Maria, additional, Canas, Sonia Raquelline Roque, additional, Ujvari, Stefan Cunha, additional, Kasabkojian, Stephanie Toscano, additional, Sahn, Steven Alan, additional, Jamieson, Stuart, additional, Bianchini, Suzana Maria, additional, Takahashi, Tiago Kenji, additional, Machuca, Tiago Noguchi, additional, Ribeiro Jr, Ulysses, additional, Rusch, Valerie W., additional, Felix, Valter Nilton, additional, Cruz, Vasco Moscovici, additional, Pretorius, Victor, additional, Figueiredo, Viviane Rossi, additional, and Pereira Júnior, Wladimir, additional

Published
2024
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21. Clinical and Prognostic Impact of Low Diffusing Capacity for Carbon Monoxide Values in Patients With Global Initiative for Obstructive Lung Disease I COPD.

Author

de-Torres, Juan P., O'Donnell, Denis E., Marín, Jose M., Cabrera, Carlos, Casanova, Ciro, Marín, Marta, Ezponda, Ana, Cosio, Borja G., Martinez, Cristina, Solanes, Ingrid, Fuster, Antonia, Neder, J. Alberto, Gonzalez-Gutierrez, Jessica, Celli, Bartolome R., O'Donnel, Denis E, Neder, Alberto, and Gutierrez, Jessica Gonzalez

Subjects
OBSTRUCTIVE lung diseases, CARBON monoxide, MORTALITY, REFERENCE values, MULTIPLE regression analysis
Abstract

Background: The Global Initiative for Obstructive Lung Disease (GOLD) does not promote diffusing capacity for carbon monoxide (Dlco) values in the evaluation of COPD. In GOLD spirometric stage I COPD patients, the clinical and prognostic impact of a low Dlco has not been explored.Research Question: Could a Dlco threshold help define an increased risk of death and a different clinical presentation in these patients?Study Design and Methods: GOLD stage I COPD patients (n = 360) were enrolled and followed over 109 ± 50 months. Age, sex, pack-years' history, BMI, dyspnea, lung function measurements, exercise capacity, BODE index, and history of exacerbations were recorded. A cutoff value for Dlco was identified for all-cause mortality and the clinical and physiological characteristics of patients above and below the threshold compared. Cox regression analysis explored the predictive power of that cutoff value for all-cause mortality.Results: A Dlco cutoff value of <60% predicted was associated with all-cause mortality (Dlco ≥ 60%: 9% vs Dlco < 60%: 23%, P = .01). At a same FEV1% predicted and Charlson score, patients with Dlco < 60% had lower BMI, more dyspnea, lower inspiratory capacity (IC)/total lung capacity (TLC) ratio, lower 6-min walk distance (6MWD), and higher BODE. Cox multiple regression analysis confirmed that after adjusting for age, sex, pack-years history, smoking status, and BMI, a Dlco < 60% is associated with all-cause mortality (hazard ratio [HR], 95% CI = 3.37, 1.35-8.39; P = .009) INTERPRETATION: In GOLD I COPD patients, a Dlco < 60% predicted is associated with increased risk of death and worse clinical presentation. What the cause(s) of this association are and whether they can be treated need to be determined. [ABSTRACT FROM AUTHOR]

Published
2021
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