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3. MRI data-driven clustering reveals different subtypes of Dementia with Lewy bodies

Author

Inguanzo, Anna, Poulakis, Konstantinos, Mohanty, Rosaleena, Schwarz, Christopher G., Przybelski, Scott A., Diaz-Galvan, Patricia, Lowe, Val J., Boeve, Bradley F., Lemstra, Afina W., van de Beek, Marleen, van der Flier, Wiesje, Barkhof, Frederik, Blanc, Frederic, Loureiro de Sousa, Paulo, Philippi, Nathalie, Cretin, Benjamin, Demuynck, Catherine, Nedelska, Zuzana, Hort, Jakub, Segura, Barbara, Junque, Carme, Oppedal, Ketil, Aarsland, Dag, Westman, Eric, Kantarci, Kejal, and Ferreira, Daniel

Published
2023
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6. Cerebrovascular disease, neurodegeneration, and clinical phenotype in dementia with Lewy bodies

Author

Ferreira, Daniel, Nedelska, Zuzana, Graff-Radford, Jonathan, Przybelski, Scott A., Lesnick, Timothy G., Schwarz, Christopher G., Botha, Hugo, Senjem, Matthew L., Fields, Julie A., Knopman, David S., Savica, Rodolfo, Ferman, Tanis J., Graff-Radford, Neill R., Lowe, Val J., Jack, Clifford R., Petersen, Ronald C., Lemstra, Afina W., van de Beek, Marleen, Barkhof, Frederik, Blanc, Frederic, Loureiro de Sousa, Paulo, Philippi, Nathalie, Cretin, Benjamin, Demuynck, Catherine, Hort, Jakub, Oppedal, Ketil, Boeve, Bradley F., Aarsland, Dag, Westman, Eric, and Kantarci, Kejal

Published
2021
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9. Sex differences in brain atrophy in dementia with Lewy bodies

Author

Oltra, Javier, primary, Habich, Annegret, additional, Schwarz, Christopher G., additional, Nedelska, Zuzana, additional, Przybelski, Scott A., additional, Inguanzo, Anna, additional, Diaz‐Galvan, Patricia, additional, Lowe, Val J., additional, Oppedal, Ketil, additional, Gonzalez, Maria C., additional, Philippi, Nathalie, additional, Blanc, Frederic, additional, Barkhof, Frederik, additional, Lemstra, Afina W., additional, Hort, Jakub, additional, Padovani, Alessandro, additional, Rektorova, Irena, additional, Bonanni, Laura, additional, Massa, Federico, additional, Kramberger, Milica G., additional, Taylor, John‐Paul, additional, Snædal, Jon G., additional, Walker, Zuzana, additional, Antonini, Angelo, additional, Dierks, Thomas, additional, Segura, Barbara, additional, Junque, Carme, additional, Westman, Eric, additional, Boeve, Bradley F., additional, Aarsland, Dag, additional, Kantarci, Kejal, additional, and Ferreira, Daniel, additional

Published
2023
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13. The impact of breathing patterns on CSF flow and global brain BOLD signal while awake: A study using real‐time phase‐contrast MRI and fast rsfMRI

Author

Lee, Jeyeon, primary, Kang, Daehun, additional, In, Myung‐Ho, additional, Shu, Yunhong, additional, Bernstein, Matt A, additional, Ghatamaneni, Sujala, additional, Nunez, Nicolas A, additional, Park, John G, additional, Maihle, Nita J, additional, Nedelska, Zuzana, additional, Ganji, Sandeep, additional, Cogswell, Petrice M, additional, Gunter, Jeffrey L., additional, III, John Huston, additional, Botha, Hugo, additional, Graff‐Radford, Jonathan, additional, Jones, David T., additional, Petersen, Ronald C., additional, Lowe, Val J., additional, and Min, Hoon‐Ki, additional

Published
2023
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14. Diffusion Specific Segmentation: Skull Stripping with Diffusion MRI Data Alone

Author

The Alzheimer’s Disease Neuroimaging Initiative, Reid, Robert I., Nedelska, Zuzana, Schwarz, Christopher G., Ward, Chadwick, Jack, Clifford R., Jr., Hege, Hans-Christian, Series Editor, Hoffman, David, Series Editor, Johnson, Christopher R., Series Editor, Polthier, Konrad, Series Editor, Rumpf, Martin, Series Editor, Kaden, Enrico, editor, Grussu, Francesco, editor, Ning, Lipeng, editor, Tax, Chantal M. W., editor, and Veraart, Jelle, editor

Published
2018
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15. Sex differences in brain atrophy in dementia with Lewy bodies.

Author

Oltra, Javier, Habich, Annegret, Schwarz, Christopher G., Nedelska, Zuzana, Przybelski, Scott A., Inguanzo, Anna, Diaz‐Galvan, Patricia, Lowe, Val J., Oppedal, Ketil, Gonzalez, Maria C., Philippi, Nathalie, Blanc, Frederic, Barkhof, Frederik, Lemstra, Afina W., Hort, Jakub, Padovani, Alessandro, Rektorova, Irena, Bonanni, Laura, Massa, Federico, and Kramberger, Milica G.

Abstract

INTRODUCTION: Sex influences neurodegeneration, but it has been poorly investigated in dementia with Lewy bodies (DLB). We investigated sex differences in brain atrophy in DLB using magnetic resonance imaging (MRI). METHODS: We included 436 patients from the European‐DLB consortium and the Mayo Clinic. Sex differences and sex‐by‐age interactions were assessed through visual atrophy rating scales (n = 327; 73 ± 8 years, 62% males) and automated estimations of regional gray matter volume and cortical thickness (n = 165; 69 ± 9 years, 72% males). RESULTS: We found a higher likelihood of frontal atrophy and smaller volumes in six cortical regions in males and thinner olfactory cortices in females. There were significant sex‐by‐age interactions in volume (six regions) and cortical thickness (seven regions) across the entire cortex. DISCUSSION: We demonstrate that males have more widespread cortical atrophy at younger ages, but differences tend to disappear with increasing age, with males and females converging around the age of 75. Highlights: Male DLB patients had higher odds for frontal atrophy on radiological visual rating scales.Male DLB patients displayed a widespread pattern of cortical gray matter alterations on automated methods.Sex differences in gray matter measures in DLB tended to disappear with increasing age. [ABSTRACT FROM AUTHOR]

Published
2024
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17. β-Amyloid and tau biomarkers and clinical phenotype in dementia with Lewy bodies

Author

Ferreira, Daniel, Przybelski, Scott A., Lesnick, Timothy G., Lemstra, Afina W., Londos, Elisabet, Blanc, Frederic, Nedelska, Zuzana, Schwarz, Christopher G., Graff-Radford, Jonathan, Senjem, Matthew L., Fields, Julie A., Knopman, David S., Savica, Rodolfo, Ferman, Tanis J., Graff-Radford, Neill R., Lowe, Val J., Jack, Clifford R., Jr, Petersen, Ronald C., Mollenhauer, Brit, Garcia-Ptacek, Sara, Abdelnour, Carla, Hort, Jakub, Bonanni, Laura, Oppedal, Ketil, Kramberger, Milica G., Boeve, Bradley F., Aarsland, Dag, Westman, Eric, and Kantarci, Kejal

Published
2020
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18. Cognitive and motor decline in Dementia with Lewy bodies and Parkinson's Disease Dementia

Author

Gonzalez, Maria Camila, primary, Tovar‐Rios, Diego Alejandro, additional, Alves, Guido, additional, Dalen, Ingvild, additional, Williams‐Gray, Caroline H., additional, Camacho, Marta, additional, Forsgren, Lars, additional, Bäckström, David, additional, Lawson, Rachael A., additional, Macleod, Angus D., additional, Counsell, Carl E., additional, Paquet, Claire, additional, De Lena, Carlo, additional, D'Antonio, Fabrizia, additional, Pilotto, Andrea, additional, Padovani, Alessandro, additional, Blanc, Frédéric, additional, Falup‐Pecurariu, Cristian, additional, Lewis, Simon J.G., additional, Rejdak, Konrad, additional, Papuc, Ewa, additional, Hort, Jakub, additional, Nedelska, Zuzana, additional, O'Brien, John, additional, Bonanni, Laura, additional, Marquié, Marta, additional, Boada, Mercè, additional, Pytel, Vanesa, additional, Abdelnour, Carla, additional, Alcolea, Daniel, additional, Beyer, Katrin, additional, Tysnes, Ole‐Bjørn, additional, Aarsland, Dag, additional, and Maple‐Grødem, Jodi, additional

Published
2023
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19. Pathogenesis of Alzheimer's disease: Involvement of the choroid plexus

Author

Čarna, Maria, primary, Onyango, Isaac G., additional, Katina, Stanislav, additional, Holub, Dušan, additional, Novotny, Jan Sebastian, additional, Nezvedova, Marketa, additional, Jha, Durga, additional, Nedelska, Zuzana, additional, Lacovich, Valentina, additional, Vyvere, Thijs Vande, additional, Houbrechts, Ruben, additional, Garcia‐Mansfield, Krystine, additional, Sharma, Ritin, additional, David‐Dirgo, Victoria, additional, Vyhnalek, Martin, additional, Texlova, Kateřina, additional, Chaves, Hernan, additional, Bakkar, Nadine, additional, Pertierra, Lucia, additional, Vinkler, Mojmir, additional, Markova, Hana, additional, Laczo, Jan, additional, Sheardova, Kateřina, additional, Hortova‐Kohoutkova, Marcela, additional, Frič, Jan, additional, Forte, Giancarlo, additional, Kaňovsky, Petr, additional, Belaškova, Silvie, additional, Damborsky, Jiři, additional, Hort, Jakub, additional, Seyfried, Nicholas T., additional, Bowser, Robert, additional, Sevlever, Gustavo, additional, Rissman, Robert A., additional, Smith, Richard A., additional, Hajduch, Marian, additional, Pirrotte, Patrick, additional, Spacil, Zdenek, additional, Dammer, Eric B., additional, Limbäck‐Stokin, Clara, additional, and Stokin, Gorazd B., additional

Published
2023
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20. Cognitive and motor decline in dementia with lewy bodies and Parkinson's disease dementia

Author

Gonzalez, Maria Camila, Tovar-Rios, Diego Alejandro, Alves, Guido, Dalen, Ingvild, Williams-Gray, Caroline H., Camacho, Marta, Forsgren, Lars, Bäckström, David C, Lawson, Rachael A., Macleod, Angus D., Counsell, Carl E., Paquet, Claire, DeLena, Carlo, D'Antonio, Fabrizia, Pilotto, Andrea, Padovani, Alessandro, Blanc, Frédéric, Falup-Pecurariu, Cristian, Lewis, Simon J.G., Rejdak, Konrad, Papuc, Ewa, Hort, Jakub, Nedelska, Zuzana, O'Brien, John, Bonanni, Laura, Marquié, Marta, Boada, Mercè, Pytel, Vanesa, Abdelnour, Carla, Alcolea, Daniel, Beyer, Katrin, Tysnes, Ole-Bjørn, Aarsland, Dag, Maple-Grødem, Jodi, Gonzalez, Maria Camila, Tovar-Rios, Diego Alejandro, Alves, Guido, Dalen, Ingvild, Williams-Gray, Caroline H., Camacho, Marta, Forsgren, Lars, Bäckström, David C, Lawson, Rachael A., Macleod, Angus D., Counsell, Carl E., Paquet, Claire, DeLena, Carlo, D'Antonio, Fabrizia, Pilotto, Andrea, Padovani, Alessandro, Blanc, Frédéric, Falup-Pecurariu, Cristian, Lewis, Simon J.G., Rejdak, Konrad, Papuc, Ewa, Hort, Jakub, Nedelska, Zuzana, O'Brien, John, Bonanni, Laura, Marquié, Marta, Boada, Mercè, Pytel, Vanesa, Abdelnour, Carla, Alcolea, Daniel, Beyer, Katrin, Tysnes, Ole-Bjørn, Aarsland, Dag, and Maple-Grødem, Jodi

Abstract

Background: There is a need to better understand the rate of cognitive and motor decline of Dementia with Lewy bodies (DLB) and Parkinson's disease Dementia (PDD). Objectives: To compare the rate of cognitive and motor decline in patients with DLB and PDD from the E-DLB Consortium and the Parkinson's Incidence Cohorts Collaboration (PICC) Cohorts. Methods: The annual change in MMSE and MDS-UPDRS part III was estimated using linear mixed regression models in patients with at least one follow-up (DLB n = 837 and PDD n = 157). Results: When adjusting for confounders, we found no difference in the annual change in MMSE between DLB and PDD (−1.8 [95% CI −2.3, −1.3] vs. −1.9 [95% CI −2.6, −1.2] [P = 0.74]). MDS-UPDRS part III showed nearly identical annual changes (DLB 4.8 [95% CI 2.1, 7.5]) (PDD 4.8 [95% CI 2.7, 6.9], [P = 0.98]). Conclusions: DLB and PDD showed similar rates of cognitive and motor decline. This is relevant for future clinical trial designs.

Published
2023
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23. Pattern of brain atrophy rates in autopsy-confirmed dementia with Lewy bodies

Author

Nedelska, Zuzana, Ferman, Tanis J., Boeve, Bradley F., Przybelski, Scott A., Lesnick, Timothy G., Murray, Melissa E., Gunter, Jeffrey L., Senjem, Matthew L., Vemuri, Prashanti, Smith, Glenn E., Geda, Yonas E., Graff-Radford, Jonathan, Knopman, David S., Petersen, Ronald C., Parisi, Joseph E., Dickson, Dennis W., Jack, Clifford R., Jr., and Kantarci, Kejal

Published
2015
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29. MRI data-driven clustering reveals different subtypes of Dementia with Lewy bodies

Author

Ferreira, Daniel, primary, Inguanzo, Anna, additional, Poulakis, Konstantinos, additional, Mohanty, Rosaleena, additional, Schwarz, Christopher, additional, Przybelski, Scott, additional, Diaz-Galvan, Patricia, additional, Lowe, Val, additional, Boeve, Bradley, additional, Lemstra, Afina, additional, de Beek, M. van, additional, Flier, Wiesje van der, additional, Barkhof, Frederik, additional, Blanc, Frederic, additional, de Sousa, Paulo Loureiro, additional, Philippi, Nathalie, additional, Cretin, Benjamin, additional, Demuynck, Catherine, additional, Nedelska, Zuzana, additional, Hort, Jakub, additional, Segura, Bàrbara, additional, Junque, Carme, additional, Oppedal, Ketil, additional, Aarsland, Dag, additional, Westman, Eric, additional, and Kantarci, Kejal, additional

Published
2022
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31. Different Profiles of Spatial Navigation Deficits In Alzheimer’s Disease Biomarker-Positive Versus Biomarker-Negative Older Adults With Amnestic Mild Cognitive Impairment

Author

Laczó, Martina, primary, Martinkovic, Lukas, additional, Lerch, Ondrej, additional, Wiener, Jan M., additional, Kalinova, Jana, additional, Matuskova, Veronika, additional, Nedelska, Zuzana, additional, Vyhnalek, Martin, additional, Hort, Jakub, additional, and Laczó, Jan, additional

Published
2022
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33. Memory Binding Test and Its Associations With Hippocampal Volume Across the Cognitive Continuum Preceding Dementia.

Author

Markova, Hana, Fendrych Mazancova, Adela, Jester, Dylan J., Cechova, Katerina, Matuskova, Veronika, Nikolai, Tomas, Nedelska, Zuzana, Uller, Miroslav, Andel, Ross, Laczó, Jan, Hort, Jakub, and Vyhnalek, Martin

Subjects
MEMORY, HIPPOCAMPUS (Brain), ALZHEIMER'S disease, MILD cognitive impairment, RESEARCH funding, COGNITIVE testing, PROMPTS (Psychology), DISEASE complications
Abstract

Innovative memory paradigms have been introduced to capture subtle memory changes in early Alzheimer's disease (AD). We aimed to examine the associations between different indexes of the challenging Memory Binding Test (MBT) and hippocampal volume (HV) in a sample of individuals with subjective cognitive decline (SCD; n = 50), amnestic mild cognitive impairment (aMCI) due to AD (n = 31), and cognitively normal (CN) older adults (n = 29) recruited from the Czech Brain Aging Study, in contrast to traditional verbal memory tests. Both MBT free and cued recall scores in immediate and delayed recall conditions were associated with lower HV in both SCD and aMCI due to AD, whereas in traditional verbal memory tests only delayed recall scores were associated with lower HV. In SCD, the associations with lower HV in the immediate recall covered specific cued recall indexes only. In conclusion, the MBT is a promising test for detecting subtle hippocampal-associated memory decline during the predementia continuum. [ABSTRACT FROM AUTHOR]

Published
2023
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36. Longitudinal atrophy in prodromal dementia with Lewy bodies points to cholinergic degeneration

Author

Kantarci, Kejal, primary, Nedelska, Zuzana, additional, Chen, Qin, additional, Senjem, Matthew L., additional, Schwarz, Christopher G., additional, Gunter, Jeffrey L., additional, Przybelski, Scott A., additional, Lesnick, Timothy G., additional, Kremers, Walter K., additional, Fields, Julie A., additional, Graff-Radford, Jonathan, additional, Savica, Rodolfo, additional, Jones, David, additional, Botha, Hugo, additional, Knopman, David S., additional, Lowe, Val, additional, Graff-Radford, Neill R., additional, Murray, Melissa M., additional, Dickson, Dennis W., additional, Reichard, R. Ross, additional, Jack, Clifford R., additional, Petersen, Ronald C., additional, Ferman, Tanis J., additional, and Boeve, Bradley F., additional

Published
2022
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37. sj-docx-3-asm-10.1177_10731911211069676 ��� Supplemental material for Memory Binding Test and Its Associations With Hippocampal Volume Across the Cognitive Continuum Preceding Dementia

Author

Markova, Hana, Fendrych Mazancova, Adela, Jester, Dylan J., Cechova, Katerina, Matuskova, Veronika, Nikolai, Tomas, Nedelska, Zuzana, Uller, Miroslav, Andel, Ross, Lacz��, Jan, Hort, Jakub, and Vyhnalek, Martin

Subjects
FOS: Psychology, 160807 Sociological Methodology and Research Methods, 170199 Psychology not elsewhere classified, FOS: Sociology
Abstract

Supplemental material, sj-docx-3-asm-10.1177_10731911211069676 for Memory Binding Test and Its Associations With Hippocampal Volume Across the Cognitive Continuum Preceding Dementia by Hana Markova, Adela Fendrych Mazancova, Dylan J. Jester, Katerina Cechova, Veronika Matuskova, Tomas Nikolai, Zuzana Nedelska, Miroslav Uller, Ross Andel, Jan Lacz��, Jakub Hort and Martin Vyhnalek in Assessment

Published
2022
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38. sj-docx-1-asm-10.1177_10731911211069676 ��� Supplemental material for Memory Binding Test and Its Associations With Hippocampal Volume Across the Cognitive Continuum Preceding Dementia

Author

Markova, Hana, Fendrych Mazancova, Adela, Jester, Dylan J., Cechova, Katerina, Matuskova, Veronika, Nikolai, Tomas, Nedelska, Zuzana, Uller, Miroslav, Andel, Ross, Lacz��, Jan, Hort, Jakub, and Vyhnalek, Martin

Subjects
FOS: Psychology, 160807 Sociological Methodology and Research Methods, 170199 Psychology not elsewhere classified, FOS: Sociology
Abstract

Supplemental material, sj-docx-1-asm-10.1177_10731911211069676 for Memory Binding Test and Its Associations With Hippocampal Volume Across the Cognitive Continuum Preceding Dementia by Hana Markova, Adela Fendrych Mazancova, Dylan J. Jester, Katerina Cechova, Veronika Matuskova, Tomas Nikolai, Zuzana Nedelska, Miroslav Uller, Ross Andel, Jan Lacz��, Jakub Hort and Martin Vyhnalek in Assessment

Published
2022
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39. sj-docx-2-asm-10.1177_10731911211069676 ��� Supplemental material for Memory Binding Test and Its Associations With Hippocampal Volume Across the Cognitive Continuum Preceding Dementia

Author

Markova, Hana, Fendrych Mazancova, Adela, Jester, Dylan J., Cechova, Katerina, Matuskova, Veronika, Nikolai, Tomas, Nedelska, Zuzana, Uller, Miroslav, Andel, Ross, Lacz��, Jan, Hort, Jakub, and Vyhnalek, Martin

Subjects
FOS: Psychology, 160807 Sociological Methodology and Research Methods, 170199 Psychology not elsewhere classified, FOS: Sociology
Abstract

Supplemental material, sj-docx-2-asm-10.1177_10731911211069676 for Memory Binding Test and Its Associations With Hippocampal Volume Across the Cognitive Continuum Preceding Dementia by Hana Markova, Adela Fendrych Mazancova, Dylan J. Jester, Katerina Cechova, Veronika Matuskova, Tomas Nikolai, Zuzana Nedelska, Miroslav Uller, Ross Andel, Jan Lacz��, Jakub Hort and Martin Vyhnalek in Assessment

Published
2022
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40. Memory Binding Test and Its Associations With Hippocampal Volume Across the Cognitive Continuum Preceding Dementia

Author

Markova, Hana, primary, Fendrych Mazancova, Adela, additional, Jester, Dylan J., additional, Cechova, Katerina, additional, Matuskova, Veronika, additional, Nikolai, Tomas, additional, Nedelska, Zuzana, additional, Uller, Miroslav, additional, Andel, Ross, additional, Laczó, Jan, additional, Hort, Jakub, additional, and Vyhnalek, Martin, additional

Published
2022
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42. Dementia with Lewy bodies subtypes identified by cluster analysis on structural MRI

Author

Inguanzo, Anna, primary, Poulakis, Konstantinos, additional, Mohanty, Rosaleena, additional, Schwarz, Christopher G., additional, Przybelski, Scott A., additional, Lemstra, Afina W., additional, van de Beek, Marleen, additional, van der Flier, Wiesje M, additional, Barkhof, Frederik, additional, Blanc, Frédéric, additional, de Sousa, Paulo Loureiro, additional, Philippi, Nathalie, additional, Cretin, Benjamin, additional, Demuynck, Catherine, additional, Nedelska, Zuzana, additional, Hort, Jakub, additional, Segura, Barbara, additional, Junqué, Carme, additional, Oppedal, Ketil, additional, Aarsland, Dag, additional, Westman, Eric, additional, Kantarci, Kejal, additional, and Ferreira, Daniel, additional

Published
2021
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44. Pathogenesis of Alzheimer’s disease: Involvement of the Choroid Plexus

Author

Čarna, Maria, primary, Onyango, Isaac G., additional, Katina, Stanislav, additional, Holub, Dušan, additional, Nezvedova, Marketa, additional, Jha, Durga, additional, Nedelska, Zuzana, additional, Lacovich, Valentina, additional, Vyvere, Thijs Vande, additional, Houbrechts, Ruben, additional, Garcia-Mansfield, Krystine, additional, Sharma, Ritin, additional, David-Dirgo, Victoria, additional, Vyhnalek, Martin, additional, Texlova, Kateřina, additional, Chaves, Hernan, additional, Bakkar, Nadine, additional, Pertierra, Lucia, additional, Vinkler, Mojmir, additional, Markova, Hana, additional, Laczo, Jan, additional, Sheardova, Kateřina, additional, Frič, Jan, additional, Pompeano, Antonio, additional, Forte, Giancarlo, additional, Kaňovsky, Petr, additional, Belaškova, Silvie, additional, Damborsky, Jiři, additional, Hort, Jakub, additional, Seyfried, Nicholas T., additional, Bowser, Robert, additional, Sevlever, Gustavo, additional, Rissman, Robert A., additional, Smith, Richard A., additional, Hajduch, Marian, additional, Pirrotte, Patrick, additional, Spačil, Zdeněk, additional, Dammer, Eric B., additional, Limbäck-Stokin, Clara, additional, and Stokin, Gorazd B., additional

Published
2021
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47. The Association Between Homocysteine and Memory in Older Adults

Author

Nelson, Monica E., primary, Andel, Ross, additional, Nedelska, Zuzana, additional, Martinkova, Julie, additional, Cechova, Katerina, additional, Markova, Hana, additional, Matuskova, Veronika, additional, Nikolai, Tomas, additional, Lerch, Ondrej, additional, Parizkova, Martina, additional, Laczo, Jan, additional, Vyhnalek, Martin, additional, and Hort, Jakub, additional

Published
2021
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48. Thalamic Atrophy Plays a Crucial Role in the Effect of Asymptomatic Carotid Stenosis on Cognitive Impairment

Author

Zhang,Wen, Qing,Zhao, Hu,Yongwei, Shao,Mingran, Lu,Jiaming, Wang,Junxia, Li,Ming, Zhang,Xin, Nedelska,Zuzana, Hort,Jakub, Wang,Zhishun, Qiao,Tong, and Zhang,Bing

Subjects
Clinical Interventions in Aging
Abstract

Wen Zhang,1 Zhao Qing,1 Yongwei Hu,2 Mingran Shao,1 Jiaming Lu,1 Junxia Wang,1 Ming Li,1 Xin Zhang,1 Zuzana Nedelska,3 Jakub Hort,3 Zhishun Wang,4 Tong Qiao,5 Bing Zhang1 1Department of Radiology, Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, People’s Republic of China; 2Department of Vascular and Interventional Radiology, Wujin People’s Hospital Affiliated to Jiangsu University, Changzhou, People’s Republic of China; 3Department of Neurology, Memory Clinic, 2nd Faculty of Medicine, Charles University and Motol University Hospital, Prague, Czech Republic; 4Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA; 5Department of Vascular Surgery, Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, People’s Republic of ChinaCorrespondence: Bing ZhangDepartment of Radiology, Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, No. 321 Zhongshan Road, Nanjing 210008, People’s Republic of ChinaTel +86 15851803070Email zhangbing_nanjing@nju.edu.cnTong QiaoDepartment of Vascular Surgery, Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, No. 321 Zhongshan Road, Nanjing 210008, People’s Republic of ChinaTel +86 15951985338Email qiaotongmail@aliyun.comPurpose: Our objectives were to assess the abnormalities of subcortical nuclei by combining volume and shape analyses and potential association with cognitive impairment.Patients and Methods: Twenty-nine patients with severe ACS of the unilateral internal carotid artery and 31 controls were enrolled between January 2017 to August 2018. All participants underwent a comprehensive neuropsychological evaluation, blood lipid biochemical measurements, and structural magnetic resonance imaging (MRI) to measure subcortical volumes and sub-regional shape deformations. Basic statistics, correction for multiple comparisons. Seventeen ACS patients underwent carotid endarterectomy (CEA) within one week after baseline measurements, cognitive assessments and MRI scans were repeated 6 months after CEA.Results: The ACS patients had higher apolipoprotein B/apolipoprotein A1 (ApoB/ApoA1) ratio and worse performance in all cognitive domains than controls. Moreover, the ACS patients showed more profound thalamic atrophy assessed by shape and volume analysis, especially in the medial dorsal thalamus. No significant differences were found in other subcortical nuclei after multiple comparisons correction. At baseline, thalamic atrophy correlated with cognitive impairment and ApoB/ApoA1 ratio. Furthermore, mediation analysis at baseline showed that the association of carotid intima-media thickness with executive functioning was mediated by thalamic volume. After CEA, cognitive improvement and increase in the bilateral medial dorsal thalamic volume were observed.Conclusion: Our study identified the distinct atrophy of subcortical nuclei and their association with cognition in patients with ACS. Assessments of the thalamus by volumetric and shape analysis may provide an early marker for cerebral ischemia and reperfusion after CEA.Keywords: asymptomatic carotid stenosis, cognitive impairment, magnetic resonance imaging, endarterectomy, thalamus

Published
2020

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