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This study investigates the performance of 12mm copper water heat pipes embedded on horizontally oriented heat sinks under forced convection mode. Experimental and numerical studies are conducted for a blank heat sink (heat sink without heat pipe) and two identical embedded heat pipe heat sinks using two different embedding technologies as follow: 1) The first heat sink prototype consists of a heat pipe heat sink that has embedded heat pipes located in the center of its base plate thickness by means of gun drilling. 2) The second heat sink prototype consists of a heat pipe heat sink that has embedded heat pipes mounted flush with the surface of the base plate. The blank heat sink is used to benchmark the performance of the embedded heat pipe heat sinks experimentally and numerically. Four heater blocks are used to represent a standard IGBT module size 140mm x 102mm. Forced convection experiment test is done for air flow range from 5 to 50 m3/min and total power dissipation of 2kW applied through four heat load locations, heat flux of 3.43 W/cm2. The experimental results of the embedded heat pipe heat sinks show minimal thermal performance difference between the surface embedded heat pipe heat sink and internally embedded heat pipe heat sink. Both embedded heat pipe heat sinks show an improvement of 28% over the blank heat sink. The standard vapor core model available in Qfin6.1.8 was used to simulate the performance of the embedded heat pipes. The simulation model for forced convection was found to be in good agreement within less than 10% of the experimental results.

Introduction: Recent studies showed that low-level laser therapy (LLLT) accelerates the regeneration process of injured peripheral nerve tissue. The objective of this study was investigate the effect of LLLT (780 nm) on regeneration of injured right sciatic nerve of male Wistar rat. Methods: In this research work, the effect of LLLT (780 nm) on the regeneration process and reconstruction of injured peripheral right side sciatic nerve was investigated. Twelve adult male Wistar rats underwent surgery in aseptic conditions under general anesthesia to induce a lesion to their right side sciatic nerve according to standard protocol. Before suturing the location, only the experimental group was treated by laser. The damaged nerve was directly irradiated with (2 J, 100 mW, 40 seconds). The irradiation procedure was terminated in 21 days with little improvement (4 J, 200 mW, 40 seconds) across the skin surface of experimental group. Rats were selected randomly from each group to be sacrificed on different periods and histopathological examination was carried out on the extracted nerves. Results: Significant acceleration of revascularization and angiogenesis of the injury site was observed in the experimental group. Furthermore, a reduction of hemorrhages and increase in blood supply was observed. Also, Wallerian degeneration decreased while higher axonal density compared to the control rats was observed. Moreover, the cross-section analysis of the injured area on the 14th and 21st days as post-surgery showed that the nerve sheath diameter in the lesion area of the experimental group was reduced. While the ratio between thicknesses increased in the control group. Conclusion: The results of the current study suggest that laser phototherapy at 780 nm exactly could accelerate the regeneration process of injured peripheral nerves tissue.

Chronic myeloid leukemia (CML) is a hematological stem cell cancer driven by BCR-ABL1 fusion protein. We review the previous and recent evidence on the significance of CML in diagnostic and clinic management. The technical monitoring of BCR-ABL1 with quantitative real time-PCR has been used in assessing patient outcome. The cytogenetic mark of CML is Philadelphia chromosome, that is formed by reciprocal chromosomal translocations between human chromosome 9 and 22, t(9:22) (q34:q11). It makes a BCR-ABL1 fusion protein with an anomaly tyrosine kinase activity that promotes the characteristic proliferation of progenitor cells in CML and acute lymphoblastic lymphoma. The targeting of BCR-ABL1 fusion kinase is the first novel paradigm of molecularly targeted curing.

There are many of methods of treating cancer. However, the concept of curing the cancer is beyond our current knowledge. Some patients who have the cancer may seek an alternative manner of curing their disease. Alternative medicines, such as spiritual and complementary therapy, are able to cure the cancer and, at the least, are safe. Research on the importance of spirituality in cancer care has mainly been performed in geographically heterogeneous populations. The results are limited to these specific religious-cultural contexts and enlightened by contributions from ethnicity and religion. This article focused on the religiousness and spiritual support of cancer patients from diverse and heterogeneous groups around the globe. An electronic search of peer-reviewed articles was systematically performed to obtain the relevant literature with the CINAHL, PsycINFO, and PubMed databases. The keywords included religion, cancer, illness, psychotherapy, and spiritual and alternative treatment/therapies. The inclusion criteria for the reviews were that the documents were original quantitative research and published in English. Articles that were not directly relevant to the present objective were excluded. The present outcome of these review resources suggest that it may be helpful for clinicians to address spirituality, particularly with regard to prevention, healing, and survival of cancer patients. This article indicates that it may be useful for clinical oncologists to be informed of the prevalence of the use of spiritual medicine in their specialized field. In addition, patients should routinely be asked about the use of spiritual medicine as part of every cancer patient's evaluation.

The experimental study was performed to compare the effect of heat spreading for multiple heat dissipating sources on the embedded heat pipe heat sink with copper-water heat pipes vs. a blank heat sink. Experimental and numerical studies have been conducted to investigate the effect of heat dissipating sources applied to horizontally orientated heat sinks. A heater block was designed to represent a standard IGBT module size. A single power dissipating source layout, two power dissipating sources layout and three dissipating sources layout were applied on the base plate of the heat sink. It was concluded that by increasing the heat source coverage, the performance of the embedded heat pipe heat sink approached that of the blank heat sink. Qfin 6.1 was used for numerical studies in this investigation. The standard vapor core model available in Qfin 6.1 was used to simulate the performance of the embedded heat pipes. The numerical simulations results for the heat sink with partial coverage and full coverage were in good agreement with the experimental results.

Breast cancer (BC) is one of the most common cancers among women worldwide. Genetic, epigenetic, and environmental factors play a crucial role in BC development. Because epigenetic imbalance occurs earlier than expression in carcinogenesis and is reversible, epigenetic reprogramming strategies could be more useful for cancer prevention and therapy. There is evidence indicating that the use of herbal compounds with low toxicity can offer a real benefit in the prevention or treatment of cancer. Oleuropein (OLE), as a natural polyphenol, has shown the anticancer property in cancers. In this study, we investigated for the first time the link between histone deacetylase (HDAC) and OLE to have an anticancer effect in BC. The potential apoptotic and anti-invasive effects of OLE were tested using MCF-7 cells. Transcript expression of HDAC1 and HDAC4 genes after treatment was determined using quantitative reverse transcription polymerase chain reaction. OLE obviously reduced invasiveness and cell viability and simultaneously induced cell apoptosis in MCF-7 cancer cells. Dose-dependent reduction of HDAC4 was observed, whereas apparent changes could not be observed in HDAC1 expression. The current research indicated that OLE can inhibit proliferation and invasion of cells by inducing apoptosis likely through modulation of an important epigenetic factor, HDAC4, in MCF-7 cells. OLE has the potential to be a therapeutic drug for BC prevention and treatment.

The present study is to investigate the heat spreading characteristics of an embedded heat pipe heat sink versus a heat sink without embedded heat pipe. Experimental and numerical studies have been conducted to investigate the placement effect of a heat dissipating source applied to horizontally orientated heat sinks. The numerical analysis was verified with experimental testing. For the experimental testing, a heater block was designed to represent a standard IGBT module size and was applied at three different placements on the base plate of the heat sink. The three different placements for the heater block were considered with respect to the inlet air velocity direction (leading, middle and trailing edge). It was concluded that the performance of the heat sink with embedded heat pipes was not significantly affected by the placement of the heater block. The thermal modeling software Qfin 6.1 was used for the numerical analysis. Modeling of the heat pipe with high conductivity solid core assumption was also compared the standard vapor core model available in Qfin6.1. The numerical simulations results for the heat sink with and without embedded heat pipe were in good agreement with the experimental results.

Sentinel lymph node (SLN) micrometstasis detection improves outcome for breast cancer follow up procedure. The aim of the present study was to identify gene profiles that accurately predicted the outcome of breast cancer patients. Fifty tumor sample from breast cancer patients were analyzed for the expression of 3 genes using quantitative-PCR. Also clinical verification for recurrence to distant organs was performed. Three gene signature were confirmed based on tumor's stage, grade, ER status, using conditional logistic regression. Based on this findings, the negative reported lymph nodes for metastasis, had micro metastasis in significant values. There was a significant difference between normal and cancer samples in 3 gene expression marker and also there was meaningful relationship between three gene expression with tumor's grade, stage according to progression of tumor. A novel gene expression signature predictive of micro metastatic patients was evaluated. In this assessment, relationship between this gene with tumor's features that finding clear role for these genes with tumor's outcome, needs to be established.

The purpose of the present work was to investigate numerically the effect of the top and/or bottom blind openings on the convective heat transfer from a window fitted with a double-layered top down-bottom up honeycomb blind system. Top down-bottom up systems that utilize so-called honeycomb (or cellular) blinds can be opened at the top and/or the bottom. When a honeycomb blind is fully closed there are two or more vertical blind portions and a series of horizontal or nearly horizontal blind portions which join the vertical portions and form a column of cells. This gives the blind system its honeycomb or cellular structure. When opening a honeycomb blind the vertical portions of the blind bend or fold allowing the overall height of the blind to decrease. A double-layered honeycomb blind is constructed with three vertical blind portions and two columns of cells. A recessed window has been considered in the present study and only the convective heat transfer from the window to the surrounding room has been investigated. The surfaces of the blind are assumed to offer no resistance to heat transfer. The commercial CFD solver ANSYS FLUENT© has been used to obtain the solution. Over the range of parameters considered in this study, both laminar and turbulent flow can occur. The k-ε turbulence model has been used in obtaining the solutions. The convective heat transfer rate from the inner surface of the window, expressed in terms of a mean Nusselt number based on the window height and the difference between the window and the air temperatures, will depend on the Rayleigh number, also based on the window height, and the difference between the window and the air temperatures, the dimensionless top and bottom blind openings, and the dimensionless window recess depth. Variations of the mean Nusselt number with Rayleigh number for various values of these other parameters have been obtained and the results used to study how these other parameters affect the window heat transfer rate.

The membrane epithelial mucin MUC1 is expressed at the luminal surface of most simple epithelial cells, but expression is greatly increased in most breast cancers. The aims of present study were to investigate expression of the MUC1 gene and interactive affects in metastases. Whole cell RNA isolation from 50 sentinel lymph nodes (SNLs) of breast cancer patients was performed using reverse transcription and real-time PCR. All patients were diagnosed with breast cancer and without metastasis, confirmed by IHC staining. The evaluation of tumor and normal samples for expression of MUC1 gene, the results were 49.1% non-expressive and 45.3% expression (Student t, p = 0.03). Also in comparison of normal breast tissue and breast cancer SLN for MUC1 gene, MUC1 negative SLNs were 75.0% (18 samples) and MUC1 positive samples were 25.0% (6 samples). Over-expression of MUC1 gene may offer a target for therapy related to progression and metastasis in women with breast cancer.

Breast cancer is the most common cancer in women around the world, and novel prognosis strategies is needed to control more accurate and effective of this malignant disease. Among the latest prognostic markers is E-cadherin, which mediates cell-cell adhesion by associating with catenins. Loss of E-cadherin gene (CDH1) function by genetic or epigenetic alteration leads to tumorigenesis. The aim of our study was to investigate E-cadherin gene promoter methylation in breast cancer, and its correlation with E-cadherin protein expression. Fifty primary breast cancers tissue with ductal type and 50 normal breast sample from the same patients that was located adjacent to tumor region as controls were provided by Imam Reza-based referral and teaching hospital affiliated to Tabriz University of Medical Sciences, Tabriz, Iran. CDH1 promoter region CpG sites methylation and E-cadherin protein expression were determined by bisulfite-specific polymerase chain reaction and Western blot analysis, and the resulting products were sequenced on an ABI automated sequencer for firm conclusion. CDH1 hypermethylation in breast tumor specimen (ductal type) was observed in 94 % (47 of 50) comparing with normal samples methylation, and the significant difference was (p = 0.000). Protein expression in tumor samples tends to diminish with the CDH1 promoter region methylation. In the group of 50 ductal carcinomas cases, most of the cases showing CDH1 hypermethylation correlated inversely with the reduced levels of expression of E-cadherin proteins (95 % of full-methylated tumor samples had no protein expression, and 4.5 % of them had weak expression levels). Possible association was observed between CDH1 methylation and its protein expression (p = 0.000). The results of methylation analysis in promoter region in ten CpG sites (863, 865, 873, 879, 887, 892, 901, 918, 920, and 940) suggested that abnormal CDH1 methylation occurs in high frequencies in ductal breast tumors probably sounds the process of carcinogenesis progression.

Breast cancer is the most prevalent type of cancer among women around the world, and mortality is primarily caused by micro-metastatic disease. The complex mechanisms of breast cancer invasion and metastasis are intrinsically related to the malignant cell type so that early detection of micro-metastases can help prolongation of survival for patient. The aim of the present research work was evaluation of the expression status of mammoglobin protein as a candidate molecular marker in the negative sentinel lymph node (SLN). Fifty tumor specimens, and 50 normal adjacent breast tissue samples from the same patients were selected on the basis of having more than 10% tumor content for RNA extraction from SLNs. Tumor samples and normal adjacent breast tissue were archived in the form of frozen fresh tissue in liquid nitrogen. Real-time PCR was performed on a Bioner life express gradient thermal cycler system. Mammoglobin gene overexpression in breast cancer metastasis was investigated. Single marker results were mammaglobin 66.7% and CK19 50.0%, with 58.3% for the two in combination. Due to improved outcome with at least 3 genes (83.3%), it seems, triple marker evaluation will be most likely useful for detecting micro-metastases instead of studying separate genes.