Search

Your search keyword '"Neckers, Leonard M."' showing total 317 results
Start Over Author "Neckers, Leonard M."
317 results on '"Neckers, Leonard M."'

1. Second international symposium on the chaperone code, 2023

Author

Buchner, Johannes, Alasady, Milad J., Backe, Sarah J., Blagg, Brian S.J., Carpenter, Richard L., Colombo, Giorgio, Gelis, Ioannis, Gewirth, Daniel T., Gierasch, Lila M., Houry, Walid A., Johnson, Jill L., Kang, Byoung Heon, Kao, Aimee W., LaPointe, Paul, Mattoo, Seema, McClellan, Amie J., Neckers, Leonard M., Prodromou, Chrisostomos, Rasola, Andrea, Sager, Rebecca A., Theodoraki, Maria A., Truman, Andrew W., Truttman, Matthias C., Zachara, Natasha E., Bourboulia, Dimitra, Mollapour, Mehdi, and Woodford, Mark R.

Published
2024

2. Mitoribosome sensitivity to HSP70 inhibition uncovers metabolic liabilities of castration-resistant prostate cancer.

Author

Echtenkamp, Frank J, Ishida, Ryo, Rivera-Marquez, Genesis M, Maisiak, Marisa, Johnson, Oleta T, Shrimp, Jonathan H, Sinha, Arnav, Ralph, Stephen John, Nisbet, Ian, Cherukuri, Murali Krishna, Gestwicki, Jason E, and Neckers, Leonard M

Subjects
Urologic Diseases, Cancer, Aging, Prostate Cancer, Aetiology, 2.1 Biological and endogenous factors
Abstract

The androgen receptor is a key regulator of prostate cancer and the principal target of current prostate cancer therapies collectively termed androgen deprivation therapies. Insensitivity to these drugs is a hallmark of progression to a terminal disease state termed castration-resistant prostate cancer. Therefore, novel therapeutic options that slow progression of castration-resistant prostate cancer and combine effectively with existing agents are in urgent need. We show that JG-98, an allosteric inhibitor of HSP70, re-sensitizes castration-resistant prostate cancer to androgen deprivation drugs by targeting mitochondrial HSP70 (HSPA9) to suppress aerobic respiration. Rather than impacting androgen receptor stability as previously described, JG-98's primary effect is inhibition of mitochondrial translation, leading to disruption of electron transport chain activity. Although functionally distinct from HSPA9 inhibition, direct inhibition of the electron transport chain with a complex I or II inhibitor creates a similar physiological state capable of re-sensitizing castration-resistant prostate cancer to androgen deprivation therapies. These data identify a significant role for HspA9 in mitochondrial ribosome function and highlight an actionable metabolic vulnerability of castration-resistant prostate cancer.

Published
2023

3. Genome-Wide Analysis Identifies Nuclear Factor 1C as a Novel Transcription Factor and Potential Therapeutic Target in SCLC

Author

Shukla, Vivek, Wang, Haitao, Varticovski, Lyuba, Baek, Songjoon, Wang, Ruihong, Wu, Xinwei, Echtenkamp, Frank, Villa-Hernandez, Frank, Prothro, Katherine P., Gara, Sudheer K., Zhang, Mary R., Shiffka, Stephanie, Raziuddin, Razi, Neckers, Leonard M., Linehan, W. Marston, Chen, Haobin, Hager, Gordon L., and Schrump, David S.

Published
2024
Full Text
View/download PDF

4. Pharmacologic dissection of the overlapping impact of heat shock protein family members on platelet function

Author

Jackson, Joseph W, Rivera-Marquez, Genesis M, Beebe, Kristin, Tran, Andy D, Trepel, Jane B, Gestwicki, Jason E, Blagg, Brian SJ, Ohkubo, Shuichi, and Neckers, Leonard M

Subjects
Biomedical and Clinical Sciences, Cardiovascular Medicine and Haematology, Clinical Sciences, Hematology, Cancer, Underpinning research, 1.1 Normal biological development and functioning, Cardiovascular, Blood Platelets, Heat-Shock Proteins, Hemostasis, Humans, Platelet Aggregation, Platelet Aggregation Inhibitors, Platelet Glycoprotein GPIIb-IIIa Complex, antiplatelet agents, cancer, heat shock proteins, hemostasis, platelets, Cardiorespiratory Medicine and Haematology, Cardiovascular System & Hematology, Cardiovascular medicine and haematology, Clinical sciences
Abstract

BackgroundPlatelets play a pivotal role in hemostasis, wound healing, and inflammation, and are thus implicated in a variety of diseases, including cancer. Platelet function is associated with release of granule content, cellular shape change, and upregulation of receptors that promote establishment of a thrombus and maintenance of hemostasis.ObjectivesThe role of heat shock proteins (Hsps) in modulating platelet function has been studied for a number of years, but comparative roles of individual Hsps have not been thoroughly examined.MethodsWe utilized a panel of specific inhibitors of Hsp40, Hsp70, Hsp90, and Grp94 (the endoplasmic reticulum homolog of Hsp90) to assess their impact on several aspects of platelet function.ResultsInhibition of each of the aforementioned Hsps reduced alpha granule release. In contrast, there was some selectivity in impacts on dense granule release. Thromboxane synthesis was impaired after exposure to inhibitors of Hsp40, Hsp90, and Grp94, but not after inhibition of Hsp70. Both expression of active glycoprotein IIb/IIIa (GPIIb/IIIa) and fibrinogen-induced platelet shape change were diminished by our inhibitors. In contrast, aggregation was selectively abrogated after inhibition of Hsp40 or Hsp90. Lastly, activated platelet-cancer cell interactions were reduced by inhibition of both Hsp70 and Grp94.ConclusionsThese data suggest the importance of Hsp networks in regulating platelet activity.

Published
2020

5. Mitochondrial chaperon TNF-receptor- associated protein 1 as a novel apoptotic regulator conferring susceptibility to Pneumocystis jirovecii pneumonia.

Author

Amali, Aseervatham Anusha, Paramasivam, Kathirvel, Chiung Hui Huang, Joshi, Abhinav, Hirpara, Jayshree L., Ravikumar, Sharada, Qi Hui Sam, Min Tan, Rachel Ying, Zhaohong Tan, Kumar, Dilip, Neckers, Leonard M., Pervaiz, Shazib, Foo, Roger, Y Chan, Candice Y, Jin Zhu, Lee, Cheryl, and Ann Chai, Louis Yi

Subjects
PNEUMOCYSTIS pneumonia, MONONUCLEAR leukocytes, OPPORTUNISTIC infections, GENETIC variation, OXIDATIVE phosphorylation, PNEUMOCYSTIS jiroveci
Abstract

Molecular chaperons stabilize protein folding and play a vital role in maintaining tissue homeostasis. To this intent, mitochondrial molecular chaperons may be involved in the regulation of oxidative phosphorylation and apoptosis during stress events such as infections. However, specific human infectious diseases relatable to defects in molecular chaperons have yet to be identified. To this end, we performed whole exome sequencing and functional immune assessment in a previously healthy Asian female, who experienced severe respiratory failure due to Pneumocystis jiroveci pneumonia and non-HIV-related CD4 lymphocytopenia. This revealed that a chaperon, the mitochondrial paralog of HSP90, TRAP1, may have been involved in the patient’s susceptibility to an opportunistic infection. Two rare heterozygous variants in TRAP1, E93Q, and A64T were detected. The patient’s peripheral blood mononuclear cells displayed diminished TRAP1 expression, but had increased active, cleaved caspase-3, caspase-7, and elevated IL-1β production. Transfection of A64T and E93Q variants in cell lines yielded decreased TRAP1 compared to transfected wildtype TRAP1 and re-capitulated the immunotypic phenotype of enhanced caspase-3 and caspase-7 activity. When infected with live P. jiroveci, the E93Q or A64T TRAP1 mutant expressing cells also exhibited reduced viability. Patient cells and cell lines transfected with the TRAP1 E93Q/A64T mutants had impaired respiration, glycolysis, and increased ROS production. Of note, co-expression of E93Q/A64T double mutants caused more functional aberration than either mutant singly. Taken together, our study uncovered a previously unrecognized role of TRAP1 in CD4+ lymphocytopenia, conferring susceptibility to opportunistic infections. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

6. Targeting the Hsp40/Hsp70 chaperone axis as a novel strategy to treat castration-resistant prostate cancer

Author

Moses, Michael A, Kim, Yeong Sang, Rivera-Marquez, Genesis M, Oshima, Nobu, Watson, Matthew J, Beebe, Kristin E, Wells, Catherine, Lee, Sunmin, Zuehlke, Abbey D, Shao, Hao, Bingman, William E, Kumar, Vineet, Malhotra, Sanjay V, Weigel, Nancy L, Gestwicki, Jason E, Trepel, Jane B, and Neckers, Leonard M

Subjects
Aging, Genetics, Cancer, Prostate Cancer, Urologic Diseases, 5.1 Pharmaceuticals, Development of treatments and therapeutic interventions, A549 Cells, Alternative Splicing, Androgen Antagonists, Androgens, Animals, Antineoplastic Agents, COS Cells, Cell Line, Cell Line, Tumor, Chlorocebus aethiops, HEK293 Cells, HSP40 Heat-Shock Proteins, HSP70 Heat-Shock Proteins, Humans, Male, Mice, Nude, Molecular Chaperones, Prostatic Neoplasms, Castration-Resistant, RNA Splicing, Receptors, Androgen, Signal Transduction, Transcription, Genetic, Oncology and Carcinogenesis, Oncology & Carcinogenesis
Abstract

Castration-resistant prostate cancer (CRPC) is characterized by reactivation of androgen receptor (AR) signaling, in part by elevated expression of AR splice variants (ARv) including ARv7, a constitutively active, ligand binding domain (LBD)-deficient variant whose expression has been correlated with therapeutic resistance and poor prognosis. In a screen to identify small-molecule dual inhibitors of both androgen-dependent and androgen-independent AR gene signatures, we identified the chalcone C86. Binding studies using purified proteins and CRPC cell lysates revealed C86 to interact with Hsp40. Pull-down studies using biotinylated-C86 found Hsp40 present in a multiprotein complex with full-length (FL-) AR, ARv7, and Hsp70 in CRPC cells. Treatment of CRPC cells with C86 or the allosteric Hsp70 inhibitor JG98 resulted in rapid protein destabilization of both FL-AR and ARv, including ARv7, concomitant with reduced FL-AR- and ARv7-mediated transcriptional activity. The glucocorticoid receptor, whose elevated expression in a subset of CRPC also leads to androgen-independent AR target gene transcription, was also destabilized by inhibition of Hsp40 or Hsp70. In vivo, Hsp40 or Hsp70 inhibition demonstrated single-agent and combinatorial activity in a 22Rv1 CRPC xenograft model. These data reveal that, in addition to recognized roles of Hsp40 and Hsp70 in FL-AR LBD remodeling, ARv lacking the LBD remain dependent on molecular chaperones for stability and function. Our findings highlight the feasibility and potential benefit of targeting the Hsp40/Hsp70 chaperone axis to treat prostate cancer that has become resistant to standard antiandrogen therapy.Significance: These findings highlight the feasibility of targeting the Hsp40/Hsp70 chaperone axis to treat CRPC that has become resistant to standard antiandrogen therapy. Cancer Res; 78(14); 4022-35. ©2018 AACR.

Published
2018

8. Supplemental Figure S2 from Inhibition of NAD+-Dependent Metabolic Processes Induces Cellular Necrosis and Tumor Regression in Rhabdomyosarcoma Models

Author

McKay-Corkum, Grace B., primary, Collins, Victor J., primary, Yeung, Choh, primary, Ito, Takeshi, primary, Issaq, Sameer H., primary, Holland, David, primary, Vulikh, Ksenia, primary, Zhang, Yiping, primary, Lee, Unsun, primary, Lei, Haiyan, primary, Mendoza, Arnulfo, primary, Shern, Jack F., primary, Yohe, Marielle E., primary, Yamamoto, Kazutoshi, primary, Wilson, Kelli, primary, Ji, Jiuping, primary, Karim, Baktiar O., primary, Thomas, Craig J., primary, Krishna, Murali C., primary, Neckers, Leonard M., primary, and Heske, Christine M., primary

Published
2023
Full Text
View/download PDF

9. Data from Inhibition of NAD+-Dependent Metabolic Processes Induces Cellular Necrosis and Tumor Regression in Rhabdomyosarcoma Models

Author

McKay-Corkum, Grace B., primary, Collins, Victor J., primary, Yeung, Choh, primary, Ito, Takeshi, primary, Issaq, Sameer H., primary, Holland, David, primary, Vulikh, Ksenia, primary, Zhang, Yiping, primary, Lee, Unsun, primary, Lei, Haiyan, primary, Mendoza, Arnulfo, primary, Shern, Jack F., primary, Yohe, Marielle E., primary, Yamamoto, Kazutoshi, primary, Wilson, Kelli, primary, Ji, Jiuping, primary, Karim, Baktiar O., primary, Thomas, Craig J., primary, Krishna, Murali C., primary, Neckers, Leonard M., primary, and Heske, Christine M., primary

Published
2023
Full Text
View/download PDF

10. Supplemental Table S2 from Inhibition of NAD+-Dependent Metabolic Processes Induces Cellular Necrosis and Tumor Regression in Rhabdomyosarcoma Models

Author

McKay-Corkum, Grace B., primary, Collins, Victor J., primary, Yeung, Choh, primary, Ito, Takeshi, primary, Issaq, Sameer H., primary, Holland, David, primary, Vulikh, Ksenia, primary, Zhang, Yiping, primary, Lee, Unsun, primary, Lei, Haiyan, primary, Mendoza, Arnulfo, primary, Shern, Jack F., primary, Yohe, Marielle E., primary, Yamamoto, Kazutoshi, primary, Wilson, Kelli, primary, Ji, Jiuping, primary, Karim, Baktiar O., primary, Thomas, Craig J., primary, Krishna, Murali C., primary, Neckers, Leonard M., primary, and Heske, Christine M., primary

Published
2023
Full Text
View/download PDF

11. Supplemental Methods 1 from Inhibition of NAD+-Dependent Metabolic Processes Induces Cellular Necrosis and Tumor Regression in Rhabdomyosarcoma Models

Author

McKay-Corkum, Grace B., primary, Collins, Victor J., primary, Yeung, Choh, primary, Ito, Takeshi, primary, Issaq, Sameer H., primary, Holland, David, primary, Vulikh, Ksenia, primary, Zhang, Yiping, primary, Lee, Unsun, primary, Lei, Haiyan, primary, Mendoza, Arnulfo, primary, Shern, Jack F., primary, Yohe, Marielle E., primary, Yamamoto, Kazutoshi, primary, Wilson, Kelli, primary, Ji, Jiuping, primary, Karim, Baktiar O., primary, Thomas, Craig J., primary, Krishna, Murali C., primary, Neckers, Leonard M., primary, and Heske, Christine M., primary

Published
2023
Full Text
View/download PDF

15. Inhibition of NAD+-Dependent Metabolic Processes Induces Cellular Necrosis and Tumor Regression in Rhabdomyosarcoma Models

Author

McKay-Corkum, Grace B., primary, Collins, Victor J., additional, Yeung, Choh, additional, Ito, Takeshi, additional, Issaq, Sameer H., additional, Holland, David, additional, Vulikh, Ksenia, additional, Zhang, Yiping, additional, Lee, Unsun, additional, Lei, Haiyan, additional, Mendoza, Arnulfo, additional, Shern, Jack F., additional, Yohe, Marielle E., additional, Yamamoto, Kazutoshi, additional, Wilson, Kelli, additional, Ji, Jiuping, additional, Karim, Baktiar O., additional, Thomas, Craig J., additional, Krishna, Murali C., additional, Neckers, Leonard M., additional, and Heske, Christine M., additional

Published
2023
Full Text
View/download PDF

17. Table S3 from Induction of Thioredoxin-Interacting Protein by a Histone Deacetylase Inhibitor, Entinostat, Is Associated with DNA Damage and Apoptosis in Esophageal Adenocarcinoma

Author

Feingold, Paul L., primary, Surman, Deborah R., primary, Brown, Kate, primary, Xu, Yuan, primary, McDuffie, Lucas A., primary, Shukla, Vivek, primary, Reardon, Emily S., primary, Crooks, Daniel R., primary, Trepel, Jane B., primary, Lee, Sunmin, primary, Lee, Min-Jung, primary, Gao, Shaojian, primary, Xi, Sichuan, primary, McLoughlin, Kaitlin C., primary, Diggs, Laurence P., primary, Beer, David G., primary, Nancarrow, Derek J., primary, Neckers, Leonard M., primary, Davis, Jeremy L., primary, Hoang, Chuong D., primary, Hernandez, Jonathan M., primary, Schrump, David S., primary, and Ripley, R. Taylor, primary

Published
2023
Full Text
View/download PDF

18. Tables S1 and S2 from Induction of Thioredoxin-Interacting Protein by a Histone Deacetylase Inhibitor, Entinostat, Is Associated with DNA Damage and Apoptosis in Esophageal Adenocarcinoma

Author

Feingold, Paul L., primary, Surman, Deborah R., primary, Brown, Kate, primary, Xu, Yuan, primary, McDuffie, Lucas A., primary, Shukla, Vivek, primary, Reardon, Emily S., primary, Crooks, Daniel R., primary, Trepel, Jane B., primary, Lee, Sunmin, primary, Lee, Min-Jung, primary, Gao, Shaojian, primary, Xi, Sichuan, primary, McLoughlin, Kaitlin C., primary, Diggs, Laurence P., primary, Beer, David G., primary, Nancarrow, Derek J., primary, Neckers, Leonard M., primary, Davis, Jeremy L., primary, Hoang, Chuong D., primary, Hernandez, Jonathan M., primary, Schrump, David S., primary, and Ripley, R. Taylor, primary

Published
2023
Full Text
View/download PDF

19. Supplemental Figures 1-15 from Induction of Thioredoxin-Interacting Protein by a Histone Deacetylase Inhibitor, Entinostat, Is Associated with DNA Damage and Apoptosis in Esophageal Adenocarcinoma

Author

Feingold, Paul L., primary, Surman, Deborah R., primary, Brown, Kate, primary, Xu, Yuan, primary, McDuffie, Lucas A., primary, Shukla, Vivek, primary, Reardon, Emily S., primary, Crooks, Daniel R., primary, Trepel, Jane B., primary, Lee, Sunmin, primary, Lee, Min-Jung, primary, Gao, Shaojian, primary, Xi, Sichuan, primary, McLoughlin, Kaitlin C., primary, Diggs, Laurence P., primary, Beer, David G., primary, Nancarrow, Derek J., primary, Neckers, Leonard M., primary, Davis, Jeremy L., primary, Hoang, Chuong D., primary, Hernandez, Jonathan M., primary, Schrump, David S., primary, and Ripley, R. Taylor, primary

Published
2023
Full Text
View/download PDF

20. Data from Induction of Thioredoxin-Interacting Protein by a Histone Deacetylase Inhibitor, Entinostat, Is Associated with DNA Damage and Apoptosis in Esophageal Adenocarcinoma

Author

Feingold, Paul L., primary, Surman, Deborah R., primary, Brown, Kate, primary, Xu, Yuan, primary, McDuffie, Lucas A., primary, Shukla, Vivek, primary, Reardon, Emily S., primary, Crooks, Daniel R., primary, Trepel, Jane B., primary, Lee, Sunmin, primary, Lee, Min-Jung, primary, Gao, Shaojian, primary, Xi, Sichuan, primary, McLoughlin, Kaitlin C., primary, Diggs, Laurence P., primary, Beer, David G., primary, Nancarrow, Derek J., primary, Neckers, Leonard M., primary, Davis, Jeremy L., primary, Hoang, Chuong D., primary, Hernandez, Jonathan M., primary, Schrump, David S., primary, and Ripley, R. Taylor, primary

Published
2023
Full Text
View/download PDF

21. Supplementary Data from Hsp90 Inhibitor STA9090 Sensitizes Hepatocellular Carcinoma to Hyperthermia-Induced DNA Damage by Suppressing DNA-PKcs Protein Stability and mRNA Transcription

Author

Liu, Lixia, primary, Deng, Yaotang, primary, Zheng, Zhenming, primary, Deng, Zihao, primary, Zhang, Jinxin, primary, Li, Jieyou, primary, Liang, Manfeng, primary, Zhou, Xueqiong, primary, Tan, Wenchong, primary, Yang, Hongjun, primary, Neckers, Leonard M., primary, Zou, Fei, primary, and Chen, Xuemei, primary

Published
2023
Full Text
View/download PDF

22. Supplementary Figures from Hsp90 Inhibitor STA9090 Sensitizes Hepatocellular Carcinoma to Hyperthermia-Induced DNA Damage by Suppressing DNA-PKcs Protein Stability and mRNA Transcription

Author

Liu, Lixia, primary, Deng, Yaotang, primary, Zheng, Zhenming, primary, Deng, Zihao, primary, Zhang, Jinxin, primary, Li, Jieyou, primary, Liang, Manfeng, primary, Zhou, Xueqiong, primary, Tan, Wenchong, primary, Yang, Hongjun, primary, Neckers, Leonard M., primary, Zou, Fei, primary, and Chen, Xuemei, primary

Published
2023
Full Text
View/download PDF

26. Figure S1 from Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer

Author

Moses, Michael A., primary, Kim, Yeong Sang, primary, Rivera-Marquez, Genesis M., primary, Oshima, Nobu, primary, Watson, Matthew J., primary, Beebe, Kristin E., primary, Wells, Catherine, primary, Lee, Sunmin, primary, Zuehlke, Abbey D., primary, Shao, Hao, primary, Bingman, William E., primary, Kumar, Vineet, primary, Malhotra, Sanjay V., primary, Weigel, Nancy L., primary, Gestwicki, Jason E., primary, Trepel, Jane B., primary, and Neckers, Leonard M., primary

Published
2023
Full Text
View/download PDF

27. Data from Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer

Author

Moses, Michael A., primary, Kim, Yeong Sang, primary, Rivera-Marquez, Genesis M., primary, Oshima, Nobu, primary, Watson, Matthew J., primary, Beebe, Kristin E., primary, Wells, Catherine, primary, Lee, Sunmin, primary, Zuehlke, Abbey D., primary, Shao, Hao, primary, Bingman, William E., primary, Kumar, Vineet, primary, Malhotra, Sanjay V., primary, Weigel, Nancy L., primary, Gestwicki, Jason E., primary, Trepel, Jane B., primary, and Neckers, Leonard M., primary

Published
2023
Full Text
View/download PDF

28. Data from Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma

Author

Yeung, Choh, primary, Gibson, Anna E., primary, Issaq, Sameer H., primary, Oshima, Nobu, primary, Baumgart, Joshua T., primary, Edessa, Leah D., primary, Rai, Ganesha, primary, Urban, Daniel J., primary, Johnson, Michelle S., primary, Benavides, Gloria A., primary, Squadrito, Giuseppe L., primary, Yohe, Marielle E., primary, Lei, Haiyan, primary, Eldridge, Sandy, primary, Hamre, John, primary, Dowdy, Tyrone, primary, Ruiz-Rodado, Victor, primary, Lita, Adrian, primary, Mendoza, Arnulfo, primary, Shern, Jack F., primary, Larion, Mioara, primary, Helman, Lee J., primary, Stott, Gordon M., primary, Krishna, Murali C., primary, Hall, Matthew D., primary, Darley-Usmar, Victor, primary, Neckers, Leonard M., primary, and Heske, Christine M., primary

Published
2023
Full Text
View/download PDF

29. Supplemental Table 1 from Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma

Author

Yeung, Choh, primary, Gibson, Anna E., primary, Issaq, Sameer H., primary, Oshima, Nobu, primary, Baumgart, Joshua T., primary, Edessa, Leah D., primary, Rai, Ganesha, primary, Urban, Daniel J., primary, Johnson, Michelle S., primary, Benavides, Gloria A., primary, Squadrito, Giuseppe L., primary, Yohe, Marielle E., primary, Lei, Haiyan, primary, Eldridge, Sandy, primary, Hamre, John, primary, Dowdy, Tyrone, primary, Ruiz-Rodado, Victor, primary, Lita, Adrian, primary, Mendoza, Arnulfo, primary, Shern, Jack F., primary, Larion, Mioara, primary, Helman, Lee J., primary, Stott, Gordon M., primary, Krishna, Murali C., primary, Hall, Matthew D., primary, Darley-Usmar, Victor, primary, Neckers, Leonard M., primary, and Heske, Christine M., primary

Published
2023
Full Text
View/download PDF

30. Supplemental Methods from Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma

Author

Yeung, Choh, primary, Gibson, Anna E., primary, Issaq, Sameer H., primary, Oshima, Nobu, primary, Baumgart, Joshua T., primary, Edessa, Leah D., primary, Rai, Ganesha, primary, Urban, Daniel J., primary, Johnson, Michelle S., primary, Benavides, Gloria A., primary, Squadrito, Giuseppe L., primary, Yohe, Marielle E., primary, Lei, Haiyan, primary, Eldridge, Sandy, primary, Hamre, John, primary, Dowdy, Tyrone, primary, Ruiz-Rodado, Victor, primary, Lita, Adrian, primary, Mendoza, Arnulfo, primary, Shern, Jack F., primary, Larion, Mioara, primary, Helman, Lee J., primary, Stott, Gordon M., primary, Krishna, Murali C., primary, Hall, Matthew D., primary, Darley-Usmar, Victor, primary, Neckers, Leonard M., primary, and Heske, Christine M., primary

Published
2023
Full Text
View/download PDF

33. Supplemental Figures 1-14 from Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma

Author

Yeung, Choh, primary, Gibson, Anna E., primary, Issaq, Sameer H., primary, Oshima, Nobu, primary, Baumgart, Joshua T., primary, Edessa, Leah D., primary, Rai, Ganesha, primary, Urban, Daniel J., primary, Johnson, Michelle S., primary, Benavides, Gloria A., primary, Squadrito, Giuseppe L., primary, Yohe, Marielle E., primary, Lei, Haiyan, primary, Eldridge, Sandy, primary, Hamre, John, primary, Dowdy, Tyrone, primary, Ruiz-Rodado, Victor, primary, Lita, Adrian, primary, Mendoza, Arnulfo, primary, Shern, Jack F., primary, Larion, Mioara, primary, Helman, Lee J., primary, Stott, Gordon M., primary, Krishna, Murali C., primary, Hall, Matthew D., primary, Darley-Usmar, Victor, primary, Neckers, Leonard M., primary, and Heske, Christine M., primary

Published
2023
Full Text
View/download PDF

35. Supplementary Methods & Figure Legends from Targeting the Hsp40/Hsp70 Chaperone Axis as a Novel Strategy to Treat Castration-Resistant Prostate Cancer

Author

Moses, Michael A., primary, Kim, Yeong Sang, primary, Rivera-Marquez, Genesis M., primary, Oshima, Nobu, primary, Watson, Matthew J., primary, Beebe, Kristin E., primary, Wells, Catherine, primary, Lee, Sunmin, primary, Zuehlke, Abbey D., primary, Shao, Hao, primary, Bingman, William E., primary, Kumar, Vineet, primary, Malhotra, Sanjay V., primary, Weigel, Nancy L., primary, Gestwicki, Jason E., primary, Trepel, Jane B., primary, and Neckers, Leonard M., primary

Published
2023
Full Text
View/download PDF

44. HSP90-Specific nIR Probe Identifies Aggressive Prostate Cancers: Translation from Preclinical Models to a Human Phase I Study

Author

Osada, Takuya, primary, Crosby, Erika J., additional, Kaneko, Kensuke, additional, Snyder, Joshua C., additional, Ginzel, Joshua D., additional, Acharya, Chaitanya R., additional, Yang, Xiao-Yi, additional, Polascik, Thomas J., additional, Spasojevic, Ivan, additional, Nelson, Rendon C., additional, Hobeika, Amy, additional, Hartman, Zachary C., additional, Neckers, Leonard M., additional, Rogatko, Andre, additional, Hughes, Philip F., additional, Huang, Jiaoti, additional, Morse, Michael A., additional, Haystead, Timothy, additional, and Lyerly, H. Kim, additional

Published
2021
Full Text
View/download PDF

46. Hsp90 Inhibitor STA9090 Sensitizes Hepatocellular Carcinoma to Hyperthermia-Induced DNA Damage by Suppressing DNA-PKcs Protein Stability and mRNA Transcription

Author

Liu, Lixia, primary, Deng, Yaotang, additional, Zheng, Zhenming, additional, Deng, Zihao, additional, Zhang, Jinxin, additional, Li, Jieyou, additional, Liang, Manfeng, additional, Zhou, Xueqiong, additional, Tan, Wenchong, additional, Yang, Hongjun, additional, Neckers, Leonard M., additional, Zou, Fei, additional, and Chen, Xuemei, additional

Published
2021
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results