770 results on '"Neckers, Len"'
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2. Second Virtual International Symposium on Cellular and Organismal Stress Responses, September 8–9, 2022
3. Selective vulnerabilities in the proteostasis network of castration-resistant prostate cancer
4. Detecting Posttranslational Modifications of Hsp90 Isoforms
5. The XIth International Online Symposium on Heat Shock Proteins in Biology and Medicine: Organizers: Stuart K. Calderwood, Elizabeth Repasky & Len Neckers October 27-29, 2021 IN MEMORIAM: Claudina Rodrigues-Pousada (1941–2021)
6. Inhibition of HSP 90 is associated with potent anti-tumor activity in Papillary Renal Cell Carcinoma
7. Exploration of Benzothiazole Rhodacyanines as Allosteric Inhibitors of Protein-Protein Interactions with Heat Shock Protein 70 (Hsp70).
8. Phase 1 study of the HSP90 inhibitor onalespib in combination with AT7519, a pan-CDK inhibitor, in patients with advanced solid tumors
9. The IXth CSSI international symposium on heat shock proteins in biology and medicine: stress responses in health and disease: Alexandria Old Town, Alexandria, Virginia, November 10-13, 2018
10. Activation of Hsp90 Enzymatic Activity and Conformational Dynamics through Rationally Designed Allosteric Ligands
11. Molecular Chaperone Inhibitors
12. Methods to validate Hsp90 inhibitor specificity, to identify off-target effects, and to rethink approaches for further clinical development
13. Heat shock protein 90: its inhibition and function
14. Abstract 6718: Exploiting metabolic vulnerabilities of pediatric rhabdomyosarcoma with novelnicotinamide phosphoribosyltransferase (NAMPT) inhibitor OT-82
15. Chaperone-Dependent E3 Ubiquitin Ligase CHIP Mediates a Degradative Pathway for c-ErbB2/Neu
16. The mitochondrial HSP90 paralog TRAP1 forms an OXPHOS-regulated tetramer and is involved in mitochondrial metabolic homeostasis
17. Proteasome inhibition disrupts the metabolism of fumarate hydratase- deficient tumors by downregulating p62 and c-Myc
18. The XIth International Online Symposium on Heat Shock Proteins in Biology and Medicine Calderwood Stuart K. Repasky Elizabeth Neckers Len
19. Supplementary Figure 4 from The HSP90 Inhibitor Ganetespib Synergizes with the MET Kinase Inhibitor Crizotinib in both Crizotinib-Sensitive and -Resistant MET-Driven Tumor Models
20. Supplementary Figure 1 from The HSP90 Inhibitor Ganetespib Synergizes with the MET Kinase Inhibitor Crizotinib in both Crizotinib-Sensitive and -Resistant MET-Driven Tumor Models
21. Supplementary Figure Legend from The HSP90 Inhibitor Ganetespib Synergizes with the MET Kinase Inhibitor Crizotinib in both Crizotinib-Sensitive and -Resistant MET-Driven Tumor Models
22. Supplementary Table 1 from The HSP90 Inhibitor Ganetespib Synergizes with the MET Kinase Inhibitor Crizotinib in both Crizotinib-Sensitive and -Resistant MET-Driven Tumor Models
23. Supplementary Figure 3 from The HSP90 Inhibitor Ganetespib Synergizes with the MET Kinase Inhibitor Crizotinib in both Crizotinib-Sensitive and -Resistant MET-Driven Tumor Models
24. Data from The HSP90 Inhibitor Ganetespib Synergizes with the MET Kinase Inhibitor Crizotinib in both Crizotinib-Sensitive and -Resistant MET-Driven Tumor Models
25. Supplementary Figure 5 from The HSP90 Inhibitor Ganetespib Synergizes with the MET Kinase Inhibitor Crizotinib in both Crizotinib-Sensitive and -Resistant MET-Driven Tumor Models
26. Supplementary Table 2 from The HSP90 Inhibitor Ganetespib Synergizes with the MET Kinase Inhibitor Crizotinib in both Crizotinib-Sensitive and -Resistant MET-Driven Tumor Models
27. Supplementary Figure 2 from The HSP90 Inhibitor Ganetespib Synergizes with the MET Kinase Inhibitor Crizotinib in both Crizotinib-Sensitive and -Resistant MET-Driven Tumor Models
28. Mutant Conformation of p53 Translated in vitro or in vivo Requires Functional HSP90
29. Second Virtual International Symposium on Cellular and Organismal Stress Responses, September 8–9, 2022 [Meeting Review]
30. Monitoring of the Heat Shock Response with a Real-Time Luciferase Reporter
31. Detecting Posttranslational Modifications of Hsp90
32. Application of Hyperpolarized 13C-MRI to Cancer Treatment: Real-Time Monitoring of Pyruvate Metabolic Fluxes in Vivo and Targeting Intratumor Metabolic Plasticity with Small Molecules
33. Combined HSP90 and kinase inhibitor therapy: Insights from The Cancer Genome Atlas
34. Differential dependence of EGFR and ErbB2 on the molecular chaperone Hsp90
35. 17-AAG : Targeting the Molecular Chaperone Heat Shock Protein 90
36. Heat Shock Protein 90: The Cancer Chaperone
37. Targeting Hsp90 in Cancer and Neurodegenerative Disease
38. The Mitochondrial HSP90 Paralog TRAP1: Structural Dynamics, Interactome, Role in Metabolic Regulation, and Inhibitors
39. Abstract 6222: Comprehensive monitoring of pyruvate metabolism in cancer cells and tumors reveals vulnerability to metabolic inhibition therapy with small molecules
40. Optical and Radioiodinated Tethered Hsp90 Inhibitors Reveal Selective Internalization of Ectopic Hsp90 in Malignant Breast Tumor Cells
41. Englerin A Stimulates PKCθ to Inhibit Insulin Signaling and to Simultaneously Activate HSF1: Pharmacologically Induced Synthetic Lethality
42. Nuclear β-Catenin Signaling as a Target for Anticancer Drug Development
43. Editorial: A USE1ful Biomarker and Molecular Target in Lung Cancer?
44. Phase I study of the heat shock protein 90 (Hsp90) inhibitor onalespib (AT13387) administered on a daily for 2 consecutive days per week dosing schedule in patients with advanced solid tumors
45. Oxygen-independent, CDK4/CDK6-dependent degradation of hypoxia-inducible factor-1α takes cancers’ breath away
46. Impact of Posttranslational Modifications on the Anticancer Activity of Hsp90 Inhibitors
47. Hsp90 in Cancer
48. Regulation of Hsp90 Client Proteins by a Cullin5-RING E3 Ubiquitin Ligase
49. Inhibition of Hsp90 Activates Osteoclast c-Src Signaling and Promotes Growth of Prostate Carcinoma Cells in Bone
50. Hsp90 Inhibition Transiently Activates Src Kinase and Promotes Src-Dependent Akt and Erk Activation
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