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16 results on '"Nebbioso, Viviana"'

3. Efficiency of Recovery of the Bioactive Principles of Plants by Comparison between Solid–Liquid Extraction in Mixture and Single-Vegetable Matrices via Maceration and RSLDE

Author

Naviglio, Daniele, primary, Trifuoggi, Marco, additional, Varchetta, Francesca, additional, Nebbioso, Viviana, additional, Perrone, Angela, additional, Avolio, Laura, additional, De Martino, Eleonora, additional, Montesano, Domenico, additional, and Gallo, Monica, additional

Published
2023
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4. Nanocarrier-embedded gels: Precision drug delivery via liposomal and niosomal platforms.

Author

Trucillo, Paolo, Nebbioso, Viviana, Brancaccio, Raffaele, and Gigante, Laura

Subjects
LIPOSOMES, CONTROLLED release drugs, BIOLOGICAL membranes
Abstract

Recent research in drug delivery has significantly advanced our knowledge of liposome and niosome-based gels, contributing to the dynamic landscape of pharmaceutical advancements. The incorporation of these vesicular carriers into gel formulations enhanced stability, while prolonging shelf-life and improving the bioavailability of encapsulated molecules. The synergy between liposomes/niosomes and gel matrices, facilitated by a robust gel structure, provided a protective environment, ensuring sustained drug release and prolonged stability. Liposome-based gels proved to be versatile carriers for various therapeutic applications, demonstrating efficiency in solubilizing poorly soluble drugs and acting as potent penetration enhancers for optimal skin delivery. Today, the incorporation of liposomes in gels serves as local depots, thus being a fundamental condition for sustained and controlled drug release to optimize patient's outcomes. Insights into niosome-based gels reveal their potential in overcoming conventional drug delivery challenges, positioning them as promising platforms for controlled and targeted drug release due to enhanced stability. Recent investigations highlight the adaptability of niosomal gels in encapsulating both hydrophobic and hydrophilic drugs, ensuring superior stability and sustained release. The tunable properties of niosomal gels also contributed to optimize bioadhesion and permeation across biological membranes. The primary objective of this work is to present the cutting-edge findings in liposome and niosome-based gel research, highlighting their path in modern drug delivery. These innovative solutions offer more efficient and targeted therapeutic interventions, addressing the ever-evolving landscape of medicine. [ABSTRACT FROM AUTHOR]

Published
2024
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16. High Efficiency and New Potential of RSLDE: A Green Technique for the Extraction of Bioactive Molecules from Not Completely Exhausted Plant Biomass and Organic Industrial Processing Waste

Author

Daniele Naviglio, Viviana Nebbioso, Alessandro Savastano, Domenico Montesano, Paolo Trucillo, Monica Gallo, Naviglio, Daniele, Nebbioso, Viviana, Savastano, Alessandro, Montesano, Domenico, Trucillo, Paolo, and Gallo, Monica

Subjects
Fluid Flow and Transfer Processes, solid–liquid extraction, RSLDE, bioactive compounds, waste, green techniques, antioxidant activity, Process Chemistry and Technology, green technique, General Engineering, General Materials Science, Instrumentation, bioactive compound, Computer Science Applications
Abstract

A product is characterized by low environmental impact if, during the whole process (from extraction of raw materials from solid natural matter to disposal), its negative contribution to environment modification is significantly reduced or eliminated. According to circular economy, it is important to take into consideration other aspects, such as the possibility to improve the efficiency of extraction process by modifying the principle on which it is based and allowing the recovery of not completely exhausted waste, obtaining other active ingredients, and favoring the recycling of normally eliminated materials. The purpose of this work was to propose more efficient and greener alternatives to conventional solid–liquid extraction processes. Major features are the rapidity of the process, extraction at room temperature and high yields. Rapid Solid–Liquid Dynamic Extraction (RSLDE) represents an innovative solid–liquid extraction technology that allows the solid matrices containing extractable substances in an organic or inorganic solvent and their mixtures to be exhausted in shorter time than current techniques. The principle at the basis of this novel process consists of the generation of a negative pressure gradient between the inside and the outside of the solid matrix, which induces the extraction of compounds not chemically linked to the solid matter, being insoluble in the extractant liquid. Therefore, this work focuses on how RSLDE can potentially bring several improvements in the field of solid–liquid extraction, especially for industrial applications.

Published
2022

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