1. Effects of sometribove on zinc metabolism and tissue mineral concentration in dairy calves.
- Author
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Neathery MW, Crowe CT, Hartnell GF, Veenhuizen JJ, Blackmon DM, and Azain MJ
- Subjects
- Animals, Calcium analysis, Copper analysis, Growth Hormone administration & dosage, Growth Hormone pharmacology, Hormones administration & dosage, Hormones pharmacology, Human Growth Hormone, Injections, Subcutaneous veterinary, Iron analysis, Magnesium analysis, Male, Manganese analysis, Phosphorus analysis, Recombinant Proteins administration & dosage, Recombinant Proteins pharmacology, Tissue Distribution, Zinc analysis, Cattle metabolism, Growth Hormone analogs & derivatives, Minerals analysis, Zinc pharmacokinetics
- Abstract
The metabolism of Zn and tissue mineral concentrations were studied after a single oral 65Zn dose in 10 6-wk-old Holstein calves injected subcutaneously daily with 0 (control) or 10 mg of sometribove (recombinant methionyl bST) for 6 wk. Zinc-65 absorption was not significantly affected by bST; its concentration in the semitendinosus muscle was reduced by 32% in the bST calves, but concentrations in liver, pancreas, spleen, kidney, heart, small intestine, testicle, and rib were not different from controls. Manganese content was reduced by 27% in liver, 60% in kidney, 99% in spleen, 92% in testicles, and 33% in rib. Iron content of pancreas, spleen, and testicle and Zn content of rib were increased in the bST calves. The data indicate that Zn metabolism was not affected adversely by bST. Manganese content of several tissues was significantly reduced in the bST calves; however, no clinical signs of an Mn deficiency were evident. more...
- Published
- 1991
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