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10 results on '"Ndiege, I.O."'

3. Fumigant toxicity of the essential oils of some African plants against Anopheles gambiae sensu stricto

Author

Omolo, M.O., Okinyo, D., Ndiege, I.O., Lwande, W., and Hassanali, A.

Subjects
Research, Essences and essential oils -- Research, Insect repellents -- Research, Fumigants -- Research, Insect baits and repellents -- Research
Abstract

The essential oils from 15 species of African plants selected by ethnobotanical considerations and field inspection (odour and presence of insects) were screened for fumigant toxicity to Anopheles gambiae s.s. [...]

Published
2005

4. Antiplasmodial, anti-trypanosomal, anti-leishmanial and cytotoxicity activity of selected Tanzanian medicinal plants

Author

Malebo, H.M., Tanja, W., Cal, M., Swaleh, S.A.M., Omolo, M.O., Hassanali, A., Séquin, U., Hamburger, M., Brun, R., Ndiege, I.O., Malebo, H.M., Tanja, W., Cal, M., Swaleh, S.A.M., Omolo, M.O., Hassanali, A., Séquin, U., Hamburger, M., Brun, R., and Ndiege, I.O.

Abstract

The antiplasmodial, anti-trypanosomal and anti-leishmanial activity of 25 plant extracts obtained from seven Tanzanian medicinal plants: Annickia (Enantia) kummeriae (Annonaceae), Artemisia annua (Asteraceae), Pseudospondias microcarpa (Anacardiaceae), Drypetes natalensis (Euphorbiaceae), Acridocarpus chloropterus (Malpighiaceae), Maytenus senegalensis (Celastraceae) and Neurautanenia mitis (Papilonaceae), were evaluated in vitro against Plasmodium falciparum K1, Trypanosoma brucei rhodesiense STIB 900 and axenic Leishmania donovani MHOM-ET-67/82. Out of the 25 extracts tested, 17 showed good antiplasmodial activity (IC50 0.04-5.0 μg/ml), 7 exhibited moderate anti-trypanosomal activity (IC50 2.3- 2.8 μg/ml), while 5 displayed mild anti-leishmanial activity (IC50 8.8-9.79 μg/ml). A. kummeriae, A. annua, P. microcarpa, D. natalensis, M. senegalensis and N. mitis extracts had good antiplasmodial activity (IC50 0.04-2.1 μg/ml) and selectivity indices (29.2-2,250 μg/ml). The high antiplasmodial, moderate anti-trypanosomal and mild anti-leishmanial activity make these plants good candidates for bioassay-guided isolation of anti-protozoal compounds which could serve as new lead structures for drug development.

Published
2010

7. The in vitro anti-plasmodial and in vivo anti-malarial efficacy of combinations of some medicinal plants used traditionally for treatment of malaria by the Meru community in Kenya

Author

Gathirwa, J.W., primary, Rukunga, G.M., additional, Njagi, E.N.M., additional, Omar, S.A., additional, Mwitari, P.G., additional, Guantai, A.N., additional, Tolo, F.M., additional, Kimani, C.W., additional, Muthaura, C.N., additional, Kirira, P.G., additional, Ndunda, T.N., additional, Amalemba, G., additional, Mungai, G.M., additional, and Ndiege, I.O., additional

Published
2008
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10. Characterization and Evaluation of Repellent Effect of Essential Oil of Mangifera indicaL. from Kenya

Author

Alwala, O.J., Wanzala, W., Inyambukho, R.A., Osundwa, E.M., and Ndiege, I.O.

Abstract

AbstractEthnopharmacologically, the mango has a lot of applications in life in human health and ethnoveterinary medicines since ancient times. The study aimed at characterizing the essential oil of Mangifera indicaL. leaves and evaluating its repellent effect on the host-seeking female Anopheles gambiae, the vector of African malaria. The essential oil was obtained by hydrodistillation and analyzed by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). The repellent effect of the essential oil was evaluated using the human-bait technique to simulate field situation. Of the 26 major hydrocarbon compounds identified, α-pinene occurred in the largest amount (33.3 %), followed by α-phellandrene (22.6 %), Limonene (13.2 %), p-cymene (6.1 %), Heptane (3.8 %), β-pinene (2.6 %), Ledene (1.3 %), (-)-α-gurjunene (1.2 %), β-myrcene (1.1 %), γ-terpinene (1.0 %), (+)-2-carene (0.9 %) and trans(β)-caryophyllene (0.9 %) in that order. The oil showed a significant dose-dependent repellent effect on host-seeking female Anopheles gambiae s.s.The oil showed a complex composition of hydrocarbon compounds and may be richer in monoterpenes than in any other type of compounds. It showed the potential to repel mosquitoes.

Published
2010
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