1. Blood and urine inducible protein 10 as potential markers of disease activity.
- Author
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Petrone L, Cannas A, Vanini V, Cuzzi G, Aloi F, Nsubuga M, Sserunkuma J, Nazziwa RA, Jugheli L, Lukindo T, Girardi E, Antinori A, Pucci L, Reither K, and Goletti D
- Subjects
- Adult, Biomarkers blood, Biomarkers urine, CD4 Lymphocyte Count, Cross-Sectional Studies, Enzyme-Linked Immunosorbent Assay, Female, HIV Infections blood, HIV Infections urine, Humans, Interferon-gamma blood, Interleukin-6 blood, Male, Middle Aged, Tuberculosis blood, Tuberculosis urine, Young Adult, Chemokine CXCL10 blood, Chemokine CXCL10 urine, HIV Infections diagnosis, Tuberculosis diagnosis
- Abstract
Setting: Blood interferon-γ inducible protein 10 (IP-10) has been proposed as a biomarker of disease activity for both tuberculosis (TB) and human immunodeficiency virus (HIV) infection. Urine IP-10 has been detected in adults with active TB, and its level decreases after successful anti-tuberculosis treatment., Objective: To evaluate blood and urine IP-10 as biomarker of disease activity., Design: Patients with HIV-TB and active TB were enrolled. Individuals with HIV infection only and healthy donors were included as controls. Blood and urine IP-10 levels were measured using an enzyme-linked immunosorbent assay., Results: Of 39 active TB patients enrolled, 24 were HIV-infected and 15 were HIV-uninfected. Of 87 control subjects without active TB, 54 were HIV-infected and 33 were HIV-uninfected. IP-10 analysis was performed in patients with concomitant blood and urine sample collection. Blood IP-10 was associated with active TB, regardless of HIV infection status; urine IP-10 levels were increased in active TB patients, although the difference was significant in HIV-infected individuals only. Finally, in HIV-infected patients, both blood and urine IP-10 levels were inversely correlated with CD4 T-cell counts., Conclusion: These findings suggest that IP-10 could be used as a biomarker for disease activity (inflammation). more...
- Published
- 2016
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