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179 results on '"Nazzi, Vittoria"'

5. Bilateral Simultaneous Magnetic Resonance–Guided Focused Ultrasound Pallidotomy for Life‐Threatening Status Dystonicus.

Author

Levi, Vincenzo, Stanziano, Mario, Pinto, Carmela, Zibordi, Federica, Fedeli, Davide, Caldiera, Valentina, Cilia, Roberto, Golfrè Andreasi, Nico, Braccia, Arianna, Carozzi, Carla, Ciceri, Elisa, Grisoli, Marina, Gemma, Marco, Nazzi, Vittoria, DiMeco, Francesco, Eleopra, Roberto, and Zorzi, Giovanna

Abstract

Background: Invasive treatments like radiofrequency stereotactic lesioning or deep brain stimulation of the globus pallidus internus can resolve drug‐resistant status dystonicus (SD). However, these open procedures are not always feasible in patients with SD. Objective: The aim was to report the safety and efficacy of simultaneous asleep bilateral transcranial magnetic resonance–guided focused ultrasound (MRgFUS) pallidotomy for life‐threatening SD. Methods: We performed bilateral simultaneous MRgFUS pallidotomy under general anesthesia in 2 young patients with pantothenate kinase–associated neurodegeneration and GNAO1 encephalopathy. Both patients had medically refractory SD and severe comorbidities contraindicating open surgery. Results: SD resolved at 4 and 12 days after MRgFUS, respectively. Adverse events (intraoperative hypothermia and postoperative facial paralysis) were mild and transient. Conclusion: Bilateral simultaneous MRgFUS pallidotomy under general anesthesia is safe and may be a valid alternative therapeutic option for fragile patients. Further studies are needed to assess long‐term efficacy of the procedure. [ABSTRACT FROM AUTHOR]

Published
2024
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7. Focused ultrasound therapy in movement disorders: management roadmap toward optimal pathway organization

Author

Rinaldo, Sara, primary, Cilia, Roberto, additional, Leta, Valentina, additional, Gammone, Mariarosaria, additional, Andreasi, Nico Golfrè, additional, Colucci, Fabiana, additional, Braccia, Arianna, additional, Telese, Roberta, additional, Poli, Marco Fusar, additional, Levi, Vincenzo, additional, Romito, Luigi Michele Antonio, additional, Ghilemetti, Francesco, additional, De Martin, Elena, additional, Fumagalli, Maria Luisa, additional, Epifani, Francesca, additional, Prioni, Sara, additional, Amami, Paolo, additional, Piacentini, Sylvie, additional, Elia, Antonio Emanuele, additional, Devigili, Grazia, additional, Nazzi, Vittoria, additional, Ciceri, Elisa Francesca Maria, additional, Stanziano, Mario, additional, Grisoli, Marina, additional, Caldiera, Valentina, additional, Catotti, Marisa, additional, DiMeco, Francesco, additional, Moreschi, Giacomina Clara, additional, and Eleopra, Roberto, additional

Published
2024
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11. Posterior Hypothalamic Region Deep Brain Stimulation for the Treatment of Aggression Disorders in Patients with Intellectual Disability: A Systematic Review.

Author

Cojazzi, Vittoria, Innocenti, Niccolò, Castelli, Nicolò, Levi, Vincenzo, Nazzi, Vittoria, Lozano, Andres, and Rizzi, Michele

Abstract

Introduction: Aggressive disorders, in patients with intellectual disability, are satisfactorily managed with an educational, psychological, and pharmacological approach. Posterior hypothalamic region deep brain stimulation emerged in the last two decades as a promising treatment for patients with severe aggressive disorders. However, limited experiences are reported in the literature. Methods: A systematic review was performed following PRISMA guidelines and recommendations by querying PubMed and Embase on August 24th, 2022, with the ensuing string parameters: ([deep brain stimulation] OR [DBS]) AND ([aggressiv*] OR disruptive). Cochrane Library, DynaMed, and ClinicalTrials.gov were consulted using the combination of keywords "deep brain stimulation" and "aggressive" or "aggression". The clinical outcome at the last follow-up and the rate of complications were considered primary and secondary outcomes of interest. Results: The initial search identified 1,080 records, but only 10 studies met the inclusion criteria and were considered. The analysis of clinical outcome and complications was therefore performed on a total of 60 patients. Quality of all selected studies was classified as high, but one. Mean Overt Aggression Scale (OAS) improvement was 68%, while Inventory for Client Agency Planning (ICAP) improvement ranged between 38.3% and 80%. Complications occurred in 4 patients (6.7%). Conclusion: Posterior hypothalamic region deep brain stimulation may be considered a valuable option for patients with severe aggression disorders and ID. This review can represent a mainstay for those who will be engaged in the surgical treatment of these patients. [ABSTRACT FROM AUTHOR]

Published
2024
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18. Potential Circulating Biomarkers in Plasma of PNST Patients

Author

Vetrano, Ignazio Gaspare, primary, Nazzi, Vittoria, additional, Potenza, Antonella, additional, Gorla, Gemma, additional, Carrozzini, Tatiana, additional, Pollaci, Giuliana, additional, Zulueta, Aida, additional, Consonni, Alessandra, additional, and Gatti, Laura, additional

Published
2023
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27. The Lipid Asset Is Unbalanced in Peripheral Nerve Sheath Tumors

Author

Vetrano, Ignazio G., primary, Dei Cas, Michele, additional, Nazzi, Vittoria, additional, Eoli, Marica, additional, Innocenti, Niccolò, additional, Saletti, Veronica, additional, Potenza, Antonella, additional, Carrozzini, Tatiana, additional, Pollaci, Giuliana, additional, Gorla, Gemma, additional, Paroni, Rita, additional, Ghidoni, Riccardo, additional, and Gatti, Laura, additional

Published
2021
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42. Extraneural metastases in glioblastoma patients: two cases with YKL-40-positive glioblastomas and a meta-analysis of the literature

Author

Elena, Anghileri, Anghileri, Elena, Melina, Castiglione, Castiglione, Melina, Raffaele, Nunziata, Nunziata, Raffaele, Carlo, Boffano, Boffano, Carlo, Vittoria, Nazzi, Nazzi, Vittoria, Francesco, Acerbi, Acerbi, Francesco, Gaetano, Finocchiaro, Finocchiaro, Gaetano, Marica, Eoli, and Eoli, Marica

Subjects
Adult, Male, Oncology, medicine.medical_specialty, Pathology, IDH1, Bevacizumab, medicine.medical_treatment, Neurosurgical Procedures, Metastasis, Central Nervous System Neoplasms, Fatal Outcome, Adipokines, Lectins, Internal medicine, medicine, Humans, Chitinase-3-Like Protein 1, Chemotherapy, Lung, Brain Neoplasms, business.industry, Mesenchymal stem cell, General Medicine, medicine.disease, Combined Modality Therapy, Survival Analysis, nervous system diseases, Radiation therapy, Treatment Outcome, Lymphatic system, medicine.anatomical_structure, Surgery, Neurology (clinical), Glioblastoma, business, medicine.drug
Abstract

Glioblastoma (GBM) are high-grade gliomas that severely impact on overall survival (OS). GBM cell motility and the breakdown of the blood-brain barrier could favor GBM cell communication with the systemic circulation. In spite of this, extracranial GBM metastases are rare. Here, we describe two YKL-40-positive GBM patients with extra-CNS (central nervous system) metastases, and we present a meta-analysis of 94 cases. The analysis concluded that extra-CNS metastases occurred 8.5 months after first GBM diagnosis and OS was 12 months; surgical GBM excision was associated at a longer interval to extra-CNS metastasis than biopsy only, and even longer if followed by radiotherapy and chemotherapy. Both our case reports were adult males who developed extra-CNS, YKL-40-positive metastases at lymph nodes, lung and subcutaneous sites, after 86 and 24 months from initial diagnosis of GBM. At first GBM local recurrence, they were treated with bevacizumab (BV), an anti-vascular endothelial growth factor antibody. They died after 4 and 1 month from the occurrence of metastases. Both cases expressed YKL-40 and lacked EGFR amplification, suggesting a mesenchymal phenotype, and maintained such profile at extra-CNS recurrence; they did not show MGMT promoter methylation, IDH1/2 mutations, or c-Met upregulation. Our two cases and the meta-analysis support the idea that prolonged survival of GBM patients increases the probability of GBM cells shedding to lymphatic and hematic system. Interestingly, the present two cases showed the features of mesenchymal profile, usually related with worst prognosis that was maintained in extracranial metastases.

Published
2015

43. Sleeve-Shaped Neurothekeoma of the Ulnar Nerve: A Unique Case of a Still Unclear Pathological Entity.

Author

Vetrano, Ignazio G., Levi, Vincenzo, Pollo, Bianca, Chiapparini, Luisa, Messina, Giuseppe, and Nazzi, Vittoria

Abstract

Background: Neurothekeomas are slow-growing, well-circumscribed benign neoplasms. They usually involve cutaneous or subcutaneous tissues. Although originally described as myxomas deriving from nerve sheath cells, their exact histological classification is still uncertain. Peripheral nerve localization is rarely reported. Here, we describe a unique case of sleeve-shaped neurothekeoma of the ulnar nerve, which was incidentally discovered during a cubital tunnel release surgery. Methods: A 57-year-old man was admitted at our institution with clinical, ultrasonographic, and electromyographic findings highly suggestive of cubital tunnel syndrome. During ulnar nerve decompression surgery, however, no bony or ligament compression was noticed, but a segment of the nerve wrapped by a thick sleeve-shaped tissue, which had no clear-cut cleavage plane from the nerve. Given this unexpected finding, the en bloc excision of the lesion was avoided. A nerve decompression with biopsy of the swelling portion of the lesion was performed instead. Results: Histological examination described abundant myxoid stroma, with epithelioid and ring-shaped cells arranged in cords, negative to S100 protein at immunohistochemical analysis. This pattern was suggestive of neurothekeoma. The patient showed improvement in hypermyotrophy and intrinsic weakness of the hand. Conclusions: To the best of our knowledge, this is the first report of a sleeve-shaped neurothekeoma of the ulnar nerve. The exact pathological characterization of such rare entities remains uncertain. In case of peripheral nerve localization, and when a clear cleavage plane is absent, the correct management of these lesions should be that of simple nerve decompression followed by biopsy. [ABSTRACT FROM AUTHOR]

Published
2020
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46. The innervation of extensor hallucis longus muscle: an anatomical study for selective neurotomy

Author

Nazzi Vittoria, Broggi Giovanni, Messina Giuseppe, and Dones Ivano

Subjects
Male, Microsurgery, medicine.medical_specialty, Cadaver, Epineurium, Humans, Medicine, In patient, Peripheral Nerves, Fibula, Muscle, Skeletal, Nerve Transfer, Aged, Aged, 80 and over, Leg, Deep peroneal nerve, business.industry, Dissection, Peroneal Nerve, Anatomy, Middle Aged, Toes, Fascicle, Extensor hallucis longus muscle, Neurotomy, Surgery, medicine.anatomical_structure, Female, Neurology (clinical), business
Abstract

This study is aimed to describe the observable anatomical variants of the innervation of extensor hallucis longus muscle (EHLM) in order to have the surgical coordinates to perform neurotomy on the targeted branches of its innervation and to give a valuable alternative to the commonly used technique of fascicular subepineurial neurotomy in patients affected by toe hyperextension dystonia.In 15 fresh cadavers of adults, 29 lower limbs (14 right and 15 left) were studied. Anatomical dissections to isolate the innervating branches of EHLM were performed. Each branch from EHLM was analyzed by microscopical opening of the epineurium to observe the number of nerve fascicles. Various measurements were made to obtain anatomical coordinates for surgery.The distance between the most prominent point of the head of the fibula and the origin of the nervous branches innervating the EHLM is not proportional to the length of the leg. In 72.4% of the studied legs, the distance between the origin of the first branch innervating the EHLM and the origin of the deep peroneal nerve is 7 +/- 2 cm. In 80% of legs, the distance between the origin of the second branch and the origin of the deep peroneal nerve is 10 +/- 1.1 cm. In only one limb with double innervation, two fascicles were found, while in six limbs (25%) only one fascicle was found.This anatomical study traced some valuable surgical coordinates useful for the execution of a selective peripheral neurotomy on the nerve branch innervating the EHLM.

Published
2009

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