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Background: Although blood transfusions can be lifesaving but it is not without risk. It is a necessity to have knowledge about the red cell antigen phenotype frequencies in a population to provide antigen-negative compatible blood to patients with multiple alloantibodies. This is the first study on extended phenotype of blood group systems in blood donors at AFIP, Dhaka. Aim: Present study is aimed to determine the antigen frequencies of “O” blood group phenotype among donors at AFIP, Dhaka. Methods: An observational study was carried out at AFIP, Dhaka from July 2019 to December 2019. A total of 40 “O” blood group donors from blood bank of AFIP were typed for D, C, c, E, e, K, k, M, N and S antigens either by adding antisera to 3-5% of donor RBCs suspension or by using Indirect Antiglobulin Test (IAT) according to manufacturer’s instruction. Coomb’s control cells, positive and negative control cells were used as quality control. Antigens and phenotype frequencies were expressed as percentages. Results: Forty (40) blood donors belonging to “O” blood group were included for extended phenotyping. D antigen was found in 100% donors, followed by e [42.5%], C [38.13%], c [11.88%], and E [7.5%] with DCe/DCe (R1R1, 55%) as the most common phenotype. k was found to be positive in 72% of donors. In the MNS system, 57.5% donors were typed as M+N+, 32.5% as M+N-, and 10% as M-N+. S-s+ was found amongst donors with 52.5% as the commonest phenotype. Conclusion: This study was conducted to provide information about the antigen frequency of a common blood group “O” in local donors to provide antigen negative compatible blood units to multi transfused alloimmunized patients. D antigen was found in 100% donors with DCe/DCe (R1R1, 55%) as the most common phenotype. [ABSTRACT FROM AUTHOR]

Background: Squamous cell carcinoma (SCC) is a rare malignancy of invasive epithelium with keratinocyte differentiation, and it is the most common form of eyelid malignant neoplasm, comprising 5%-10% of malignancies. While SCC rarely affects the orbit, it may be involved through local invasion from a cutaneous primary site or extension by perineural invasion. Only 12 cases of primary orbital SCC have been reported until now. Here, we present a case of primary carcinoma of the right orbit with coexisting Carney's syndrome, a rare genetic disorder associated with multiple endocrine neoplasias (MEN) syndromes., Case: A 62-year-old South Asian male presented with a painful swelling in the lateral aspect of the right eyebrow and protrusion of the eyeball in August 2020. He had a history of excision of Right atrial Myxoma in March 2020. Orbital computerized tomography (CT) and positron emission tomography (PET-CT) scans revealed an enhancing soft tissue lesion in the right orbit with the involvement of frontal and ethmoid sinuses. Biopsy confirmed HPV-related poorly differentiated SCC, positive for HPV-related markers. The patient received concurrent chemo irradiation with Cisplatin. Follow-up PET-CT done 3 months later showed a new lesion appeared in the right orbital region and right lobe of thyroid. Later had surgical excision and total thyroidectomy, and histopathological examination (HPE) from orbit was reported as invasive SCC and from the thyroid was reported as synchronous papillary thyroid cancer. The patient's proptosis resolved, and subsequent PET-CT and magnetic resonance imaging (MRI) scans did not show any residual or recurrent disease., Conclusion: Primary SCC of the orbit is an extremely rare disease, and this case report presents the 13th reported case and the first one associated with Carney's syndrome. As there is no standard treatment regimen for primary SCC of the orbit, this case highlights the use of multimodality treatment, including surgical excision and chemo irradiation. The findings emphasize the importance of early detection and management of this uncommon and life-threatening condition, providing hope for patients and aiding in the prevention of recurrence., (© 2024 The Author(s). Cancer Reports published by Wiley Periodicals LLC.)

Umbilical metastases [Sister Mary Joseph's nodules (SMJN)] are relatively rare and are associated usually with advanced intra-abdominal tumors from the gastrointestinal tract (GIT) or from the gynecological malignancies and they carry poor prognosis. Here we report a case of carcinoma caecum whose initial presentation was with umbilical metastases and a review of literature in relation to the umbilical metastases from colonic tumors.

Squamous cell carcinoma in children and adolescents is extremely rare. Less than 80 case reports have been reported in the literature since it was first reported in 1868. In this article, we intend to report a case where a 16-year-old girl who presented with complaints of change in voice was found to have early-stage vocal cord carcinoma on evaluation.