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19. Global, regional, and national burden of colorectal cancer and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Author

Sharma, Rajesh, Abbasi-Kangevari, Mohsen, Abd-Rabu, Rami, Abidi, Hassan, Abu-Gharbieh, Eman, Acuna, Juan Manuel, Adhikari, Sangeet, Advani, Shailesh M, Afzal, Muhammad Sohail, Aghaie Meybodi, Mohamad, Ahinkorah, Bright Opoku, Ahmad, Sajjad, Ahmadi, Ali, Ahmadi, Sepideh, Ahmed, Haroon, Ahmed, Luai A, Ahmed, Muktar Beshir, Al Hamad, Hanadi, Alahdab, Fares, Alanezi, Fahad Mashhour, Alanzi, Turki M, Alhalaiqa, Fadwa Alhalaiqa Naji, Alimohamadi, Yousef, Alipour, Vahid, Aljunid, Syed Mohamed, Alkhayyat, Motasem, Almustanyir, Sami, Al-Raddadi, Rajaa M, Alvand, Saba, Alvis-Guzman, Nelson, Amini, Saeed, Ancuceanu, Robert, Anoushiravani, Amir, Anoushirvani, Ali Arash, Ansari-Moghaddam, Alireza, Arabloo, Jalal, Aryannejad, Armin, Asghari Jafarabadi, Mohammad, Athari, Seyyed Shamsadin, Ausloos, Floriane, Ausloos, Marcel, Awedew, Atalel Fentahun, Awoke, Mamaru Ayenew, Ayana, Tegegn Mulatu, Azadnajafabad, Sina, Azami, Hiva, Azangou-Khyavy, Mohammadreza, Azari Jafari, Amirhossein, Badiye, Ashish D, Bagherieh, Sara, Bahadory, Saeed, Baig, Atif Amin, Baker, Jennifer L, Banach, Maciej, Barrow, Amadou, Berhie, Alemshet Yirga, Besharat, Sima, Bhagat, Devidas S, Bhagavathula, Akshaya Srikanth, Bhala, Neeraj, Bhattacharyya, Krittika, Bhojaraja, Vijayalakshmi S, Bibi, Sadia, Bijani, Ali, Biondi, Antonio, Bjørge, Tone, Bodicha, Belay Boda Abule, Braithwaite, Dejana, Brenner, Hermann, Calina, Daniela, Cao, Chao, Cao, Yin, Carreras, Giulia, Carvalho, Felix, Cerin, Ester, Chakinala, Raja Chandra, Cho, William C S, Chu, Dinh-Toi, Conde, Joao, Costa, Vera Marisa, Cruz-Martins, Natália, Dadras, Omid, Dai, Xiaochen, Dandona, Lalit, Dandona, Rakhi, Danielewicz, Anna, Demeke, Feleke Mekonnen, Demissie, Getu Debalkie, Desai, Rupak, Dhamnetiya, Deepak, Dianatinasab, Mostafa, Diaz, Daniel, Didehdar, Mojtaba, Doaei, Saeid, Doan, Linh Phuong, Dodangeh, Milad, Eghbalian, Fatemeh, Ejeta, Debela Debela, Ekholuenetale, Michael, Ekundayo, Temitope Cyrus, El Sayed, Iman, Elhadi, Muhammed, Enyew, Daniel Berhanie, Eyayu, Tahir, Ezzeddini, Rana, Fakhradiyev, Ildar Ravisovich, Farooque, Umar, Farrokhpour, Hossein, Farzadfar, Farshad, Fatehizadeh, Ali, Fattahi, Hamed, Fattahi, Nima, Fereidoonnezhad, Masood, Fernandes, Eduarda, Fetensa, Getahun, Filip, Irina, Fischer, Florian, Foroutan, Masoud, Gaal, Peter Andras, Gad, Mohamed M, Gallus, Silvano, Garg, Tushar, Getachew, Tamiru, Ghamari, Seyyed-Hadi, Ghashghaee, Ahmad, Ghith, Nermin, Gholamalizadeh, Maryam, Gholizadeh Navashenaq, Jamshid, Gizaw, Abraham Tamirat, Glasbey, James C, Golechha, Mahaveer, Goleij, Pouya, Gonfa, Kebebe Bekele, Gorini, Giuseppe, Guha, Avirup, Gupta, Sapna, Gupta, Veer Bala, Gupta, Vivek Kumar, Haddadi, Rasool, Hafezi-Nejad, Nima, Haj-Mirzaian, Arvin, Halwani, Rabih, Haque, Shafiul, Hariri, Sanam, Hasaballah, Ahmed I, Hassanipour, Soheil, Hay, Simon I, Herteliu, Claudiu, Holla, Ramesh, Hosseini, Mohammad-Salar, Hosseinzadeh, Mehdi, Hostiuc, Mihaela, Househ, Mowafa, Huang, Junjie, Humayun, Ayesha, Iavicoli, Ivo, Ilesanmi, Olayinka Stephen, Ilic, Irena M, Ilic, Milena D, Islami, Farhad, Iwagami, Masao, Jahani, Mohammad Ali, Jakovljevic, Mihajlo, Javaheri, Tahereh, Jayawardena, Ranil, Jebai, Rime, Jha, Ravi Prakash, Joo, Tamas, Joseph, Nitin, Joukar, Farahnaz, Jozwiak, Jacek Jerzy, Kabir, Ali, Kalhor, Rohollah, Kamath, Ashwin, Kapoor, Neeti, Karaye, Ibraheem M, Karimi, Amirali, Kauppila, Joonas H, Kazemi, Asma, Keykhaei, Mohammad, Khader, Yousef Saleh, Khajuria, Himanshu, Khalilov, Rovshan, Khanali, Javad, Khayamzadeh, Maryam, Khodadost, Mahmoud, Kim, Hanna, Kim, Min Seo, Kisa, Adnan, Kisa, Sezer, Kolahi, Ali-Asghar, Koohestani, Hamid Reza, Kopec, Jacek A, Koteeswaran, Rajasekaran, Koyanagi, Ai, Krishnamoorthy, Yuvaraj, Kumar, G Anil, Kumar, Manoj, Kumar, Vivek, La Vecchia, Carlo, Lami, Faris Hasan, Landires, Iván, Ledda, Caterina, Lee, Sang-woong, Lee, Wei-Chen, Lee, Yeong Yeh, Leong, Elvynna, Li, Bingyu, Lim, Stephen S, Lobo, Stany W, Loureiro, Joana A, Lunevicius, Raimundas, Madadizadeh, Farzan, Mahmoodpoor, Ata, Majeed, Azeem, Malekpour, Mohammad-Reza, Malekzadeh, Reza, Malik, Ahmad Azam, Mansour-Ghanaei, Fariborz, Mantovani, Lorenzo Giovanni, Martorell, Miquel, Masoudi, Sahar, Mathur, Prashant, Meena, Jitendra Kumar, Mehrabi Nasab, Entezar, Mendoza, Walter, Mentis, Alexios-Fotios A, Mestrovic, Tomislav, Miao Jonasson, Junmei, Miazgowski, Bartosz, Miazgowski, Tomasz, Mijena, Gelana Fekadu Worku, Mirmoeeni, Seyyedmohammadsadeq, Mirza-Aghazadeh-Attari, Mohammad, Mirzaei, Hamed, Misra, Sanjeev, Mohammad, Karzan Abdulmuhsin, Mohammadi, Esmaeil, Mohammadi, Saeed, Mohammadi, Seyyede Momeneh, Mohammadian-Hafshejani, Abdollah, Mohammed, Shafiu, Mohammed, Teroj Abdulrahman, Moka, Nagabhishek, Mokdad, Ali H, Mokhtari, Zeinab, Molokhia, Mariam, Momtazmanesh, Sara, Monasta, Lorenzo, Moradi, Ghobad, Moradzadeh, Rahmatollah, Moraga, Paula, Morgado-da-Costa, Joana, Mubarik, Sumaira, Mulita, Francesk, Naghavi, Mohsen, Naimzada, Mukhammad David, Nam, Hae Sung, Natto, Zuhair S, Nayak, Biswa Prakash, Nazari, Javad, Nazemalhosseini-Mojarad, Ehsan, Negoi, Ionut, Nguyen, Cuong Tat, Nguyen, Son Hoang, Noor, Nurulamin M, Noori, Maryam, Noori, Seyyed Mohammad Ali, Nuñez-Samudio, Virginia, Nzoputam, Chimezie Igwegbe, Oancea, Bogdan, Odukoya, Oluwakemi Ololade, Oguntade, Ayodipupo Sikiru, Okati-Aliabad, Hassan, Olagunju, Andrew T, Olagunju, Tinuke O, Ong, Sokking, Ostroff, Samuel M, Padron-Monedero, Alicia, Pakzad, Reza, Pana, Adrian, Pandey, Anamika, Pashazadeh Kan, Fatemeh, Patel, Urvish K, Paudel, Uttam, Pereira, Renato B, Perumalsamy, Navaraj, Pestell, Richard G, Piracha, Zahra Zahid, Pollok, Richard Charles G, Pourshams, Akram, Pourtaheri, Naeimeh, Prashant, Akila, Rabiee, Mohammad, Rabiee, Navid, Radfar, Amir, Rafiei, Sima, Rahman, Mosiur, Rahmani, Amir Masoud, Rahmanian, Vahid, Rajai, Nazanin, Rajesh, Aashish, Ramezani-Doroh, Vajiheh, Ramezanzadeh, Kiana, Ranabhat, Kamal, Rashedi, Sina, Rashidi, Amirfarzan, Rashidi, Mahsa, Rashidi, Mohammad-Mahdi, Rastegar, Mandana, Rawaf, David Laith, Rawaf, Salman, Rawassizadeh, Reza, Razeghinia, Mohammad Sadegh, Renzaho, Andre M N, Rezaei, Negar, Rezaei, Nima, Rezaei, Saeid, Rezaeian, Mohsen, Rezazadeh-Khadem, Sahba, Roshandel, Gholamreza, Saber-Ayad, Maha Mohamed, Saberzadeh-Ardestani, Bahar, Saddik, Basema, Sadeghi, Hossein, Saeed, Umar, Sahebazzamani, Maryam, Sahebkar, Amirhossein, Salek Farrokhi, Amir, Salimi, Amir, Salimzadeh, Hamideh, Samadi, Pouria, Samaei, Mehrnoosh, Samy, Abdallah M, Sanabria, Juan, Santric-Milicevic, Milena M, Saqib, Muhammad Arif Nadeem, Sarveazad, Arash, Sathian, Brijesh, Satpathy, Maheswar, Schneider, Ione Jayce Ceola, Šekerija, Mario, Sepanlou, Sadaf G, Seylani, Allen, Sha, Feng, Shafiee, Sayed Mohammad, Shaghaghi, Zahra, Shahabi, Saeed, Shaker, Elaheh, Sharifian, Maedeh, Sharifi-Rad, Javad, Sheikhbahaei, Sara, Shetty, Jeevan K, Shirkoohi, Reza, Shobeiri, Parnian, Siddappa Malleshappa, Sudeep K, Silva, Diego Augusto Santos, Silva Julian, Guilherme, Singh, Achintya Dinesh, Singh, Jasvinder A, Siraj, Md Shahjahan, Sivandzadeh, Gholam Reza, Skryabin, Valentin Yurievich, Skryabina, Anna Aleksandrovna, Socea, Bogdan, Solmi, Marco, Soltani-Zangbar, Mohammad Sadegh, Song, Suhang, Szerencsés, Viktória, Szócska, Miklós, Tabarés-Seisdedos, Rafael, Tabibian, Elnaz, Taheri, Majid, TaheriAbkenar, Yasaman, Taherkhani, Amir, Talaat, Iman M, Tan, Ker-Kan, Tbakhi, Abdelghani, Tesfaye, Bekele, Tiyuri, Amir, Tollosa, Daniel Nigusse, Touvier, Mathilde, Tran, Bach Xuan, Tusa, Biruk Shalmeno, Ullah, Irfan, Ullah, Saif, Vacante, Marco, Valadan Tahbaz, Sahel, Veroux, Massimiliano, Vo, Bay, Vos, Theo, Wang, Cong, Westerman, Ronny, Woldemariam, Melat, Yahyazadeh Jabbari, Seyed Hossein, Yang, Lin, Yazdanpanah, Fereshteh, Yu, Chuanhua, Yuce, Deniz, Yunusa, Ismaeel, Zadnik, Vesna, Zahir, Mazyar, Zare, Iman, Zhang, Zhi-Jiang, and Zoladl, Mohammad

Published
2022
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21. Hippo Signaling Pathway in Colorectal Cancer: Modulation by Various Signals and Therapeutic Potential.

Author

Mohammadpour, Somayeh, Torshizi Esfahani, Amir, Sarpash, SeyedKasra, Vakili, Fatemeh, Zafarjafarzadeh, Nikta, Mashaollahi, Amirhesam, Pardakhtchi, Ali, Nazemalhosseini-Mojarad, Ehsan, and Lim, Yun Ping

Subjects
HIPPO signaling pathway, YAP signaling proteins, DEATH rate, CELLULAR signal transduction, GENETIC mutation
Abstract

Colorectal cancer (CRC) stands as a significant global health issue, marked by elevated occurrence and mortality statistics. Despite the availability of various treatments, including chemotherapy, radiotherapy, and targeted therapy, CRC cells often exhibit resistance to these interventions. As a result, it is imperative to identify the disease at an earlier stage and enhance the response to treatment by acquiring a deeper comprehension of the processes driving tumor formation, aggressiveness, metastasis, and resistance to therapy. The Hippo pathway plays a critical role in facilitating the initiation of tumorigenesis and frequently experiences disruption within CRC because of genetic mutations and modified expression in its fundamental constituents. Targeting upstream regulators or core Hippo pathway components may provide innovative therapeutic strategies for modulating Hippo signaling dysfunction in CRC. To advance novel therapeutic techniques for CRC, it is imperative to grasp the involvement of the Hippo pathway in CRC and its interaction with alternate signaling pathways, noncoding RNAs, gut microbiota, and the immune microenvironment. This review seeks to illuminate the function and control of the Hippo pathway in CRC, ultimately aiming to unearth innovative therapeutic methodologies for addressing this ailment. [ABSTRACT FROM AUTHOR]

Published
2024
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22. Nano-particles' benefits for colon cancer effective therapy: a review of recent advancements and clinical trials.

Author

Faraji, Ghazale, Moeini, Pedram, Rajabi Torkamani, Ali, Shafiee, Haniye, and Nazemalhosseini Mojarad, Ehsan

Subjects
COLON cancer, CANCER treatment, CLINICAL trials, NANOPARTICLES, DRUG delivery systems
Abstract

A variety of fascinating nanocarriers have reportedly been used and highlighted as novel drug delivery system in human colorectal cancer (CRC) treatment. In this context, significant progress has been achieved in the last few years and a great deal of promising NPs application has been reported as well. According to the literature reviews, the application of different types of NPs improves the efficacy, stability and selectivity of anti-colon cancer drugs. Moreover, the outcome of in vitro and in vivo experiments, also conducted preclinical and clinical investigations, has not only pushed the boundaries of knowledge but also revealed the favorable therapeutic benefits of NPs in CRC therapy more than before. Thus, scientists conclude that it is not surprising if NPs play a crucial role in CRC treatment in the near future. The present review gathers the most recent knowledge of the field, and also addresses a summary of the advancements and clinical trials conducted so far. The authors hope that the present review will provide comprehensive information about the up-to-date results of the recently conducted investigations for those who are willing to read everything at a glance. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Evaluating CD4 and Foxp3 mRNA Expression in Tissue Specimens of Celiac Disease and Colorectal Cancer Patients

Author

Asri, Nastaran, primary, Nazemalhosseini Mojarad, Ehsan, additional, Taleghani, Mohammad Yaghoob, additional, Houri, Hamidreza, additional, Saeedi Niasar, Mahsa, additional, Rezaei-Tavirani, Mostafa, additional, Jahani- Sherafat, Somayeh, additional, Shahbazkhani, Amirhossein, additional, Nikzamir, Abdolrahim, additional, Ehsani Ardakani, Mohammad Javad, additional, Khodadost, Mahmood, additional, and Rostami-Nejad, Mohammad, additional

Published
2024
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31. Rare single‐nucleotide variants of MLH1 and MSH2 genes in patients with Lynch syndrome

Author

Mirabdolhosseini, Seyed Mohsen, primary, Yaghoob Taleghani, Mohammad, additional, Rejali, Leili, additional, Sadeghi, Hossein, additional, Fatemi, Nayeralsadat, additional, Tavallaei, Mehdi, additional, Famil Meyari, Amin, additional, Saeidi, Narges, additional, Ketabi Moghadam, Pardis, additional, Sadeghi, Amir, additional, Asadzadeh Aghdaei, Hamid, additional, Zali, Mohammad Reza, additional, and Nazemalhosseini Mojarad, Ehsan, additional

Published
2023
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46. A systematic review and meta-analysis for the association of the insulin-like growth factor1 pathway genetic polymorphisms with colorectal cancer susceptibility.

Author

Cheraghpour, Makan, Askari, Masomeh, Tierling, Sascha, Shojaee, Sajad, Sadeghi, Amir, Moghadam, Pardis Ketabi, Khazdouz, Maryam, Aghdaei, Hamid Asadzadeh, Piroozkhah, Moein, Nazemalhosseini-Mojarad, Ehsan, and Fatemi, Nayeralsadat

Subjects
GENETIC polymorphisms, COLORECTAL cancer, CANCER susceptibility, SOMATOMEDIN, INSULIN receptors, HEREDITARY nonpolyposis colorectal cancer
Abstract

Background: The receptors, ligands, and associated proteins of the insulin-like growth factor (IGF) family are involved in cancer development. The IGF1 receptor and its accompanying signaling cascade are a crucial growth-regulatory mechanism that plays an important role in colorectal cancer (CRC) proliferation and differentiation. IRS1 (Insulin receptor substrate-1), a major substrate for the IGF1R, is involved in cell growth and promotes tumorigenesis. There are shreds of evidence from prior research suggesting that IGF system polymorphisms may influence susceptibility to CRC. However, the findings in this area were contradictory. Accordingly, we carried out a systematic literature search to identify all case-control, cross-sectional, and cohort studies on the association between various polymorphisms across four IGF1 pathway genes (IGF1, IGF1R, IRS1, and IRS2) and the risk of CRC. Methods: We performed a comprehensive search strategy in PubMed, Scopus, and Web of Science databases for articles available until Aug 30, 2022. A total of 26 eligible studies with IGF1/IGF1R, IRS1 and IRS2 polymorphisms; met the inclusion criteria. All case-control studies for IGF1 rs6214C>T, IRS1 rs1801278G>A, and IRS2 rs1805097G>A comprising 22,084 cases and 29,212 controls were included in the current meta-analysis. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate relationships between the polymorphisms and CRC susceptibility. All statistical analyses were performed using STATA software version 14.0. Results: The meta-analysis of available data for rs6214C>T, rs1801278G>A, and rs1805097G>A showed a significant association between these polymorphisms and an increased CRC risk in some of the comparisons studied (rs6214C>T, pooled OR for CC = 0.43, 95% CI 0.21-0.87, P = 0.019; rs1801278G>A, OR for GA = 0.74, 95% CI 0.58-0.94, P = 0.016; rs1805097G>A, OR for GA = 0.83, 95% CI 0.71-0.96, P = 0.013). Nevertheless, the meta-analysis did not include other genetic variations in IGF1, IGF1R, IRS1, and IRS2 due to heterogeneity and limited sample size. Conclusions: This systematic review and meta-analysis provide evidence that genetic variants in IGF1 rs6214C>T, IRS1 rs1801278G>A, and IRS2 rs1805097G>A are associated with an increased risk of CRC. These findings may contribute to a better understanding of the complex genetic mechanisms involved in CRC development and could inform future research on prevention and treatment strategies for this disease. [ABSTRACT FROM AUTHOR]

Published
2023
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47. Downregulation of human leukocyte antigen Class I expression: An independent prognostic factor in colorectal cancer

Author

Nazemalhosseini-Mojarad, Ehsan, Asadzadeh-Aghdaei, Hamid, Mohammadpour, Somayeh, Esfahani, Amir, Porhoseingholi, Mohammad, Molaei, Mahsa, Jalali, Amir, Kuppen, Peter K., and Zali, Mohammad

Subjects
Oncology, Experimental, Gene expression -- Research, HLA histocompatibility antigens -- Genetic aspects -- Health aspects, Colorectal cancer -- Genetic aspects -- Prognosis, Cancer -- Research, Histocompatibility antigens -- Genetic aspects -- Health aspects, Health
Abstract

Byline: Ehsan. Nazemalhosseini-Mojarad, Hamid. Asadzadeh-Aghdaei, Somayeh. Mohammadpour, Amir. Esfahani, Mohammad. Porhoseingholi, Mahsa. Molaei, Amir. Jalali, Peter. K. Kuppen, Mohammad. Zali Aim: In the present study, we evaluated the clinical prognostic [...]

Published
2020

50. High prevalence of SARS-Coronavirus-2 in patients with inflammatory bowel disease and the role of soluble angiotensin converting Enzyme2

Author

Shahrokh, Shabnam, primary, Baradaran Ghavami, Shaghayegh, additional, Asadzadeh Aghdaei, Hamid, additional, Parigi, Tommaso Lorenzo, additional, Farmani, Maryam, additional, Danese, Silvio, additional, Ebrahimi Daryani, Nasser, additional, Vossoughinia, Hassan, additional, Balaii, Hedieh, additional, Alborzi, Foroogh, additional, Khoramjoo, Seyed Mobin, additional, Khanabadi, Binazir, additional, Seyed Salehi, Ali, additional, Bastani, Ali, additional, Sharifi, Mohsen, additional, Safari, Mohammad Taghi, additional, Malekpour, Habib, additional, Sherkat, Ghazal, additional, Saberafsharian, Malihe, additional, Miri, Mohammad Bagher, additional, Moosavi, Seyed Hamid, additional, Anaraki, Fakhrosadat, additional, Nazemalhosseini-Mojarad, Ehsan, additional, Mohebbi, Seyed Reza, additional, Shojaie, Sajad, additional, Pourhoseingholi, Mohamad Amin, additional, and Zali, Mohammad Reza, additional

Published
2022
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