42 results on '"Nayak, Jennifer L"'
Search Results
2. Differences in the influenza-specific CD4 T cell immunodominance hierarchy and functional potential between children and young adults
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Shannon, Ian, White, Chantelle L., Murphy, Amy, Qiu, Xing, Treanor, John J., and Nayak, Jennifer L.
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- 2019
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3. Cell-Culture–Based Influenza Vaccines: Don’t Put All of Your Influenza Vaccines in the Egg Basket
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Nayak, Jennifer L., primary and Caserta, Mary T., additional
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- 2022
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4. Effect of Influenza A(H5N1) Vaccine Prepandemic Priming on CD4⁺ T-Cell Responses
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Nayak, Jennifer L., Richards, Katherine A., Yang, Hongmei, Treanor, John J., and Sant, Andrea J.
- Published
- 2015
5. CD4⁺ T-Cell Expansion Predicts Neutralizing Antibody Responses to Monovalent, Inactivated 2009 Pandemic Influenza A(H1N1) Virus Subtype H1N1 Vaccine
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Nayak, Jennifer L., Fitzgerald, Theresa F., Richards, Katherine A., Yang, Hongmei, Treanor, John J., and Sant, Andrea J.
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- 2013
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6. The Negative Effect of Preexisting Immunity on Influenza Vaccine Responses Transcends the Impact of Vaccine Formulation Type and Vaccination History.
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Moritzky, Savannah A, Richards, Katherine A, Glover, Maryah A, Krammer, Florian, Chaves, Francisco A, Topham, David J, Branche, Angela, Nayak, Jennifer L, and Sant, Andrea J
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FLU vaccine efficacy ,VACCINATION status ,IMMUNITY ,IMMUNOLOGIC memory ,VACCINE effectiveness ,BCG vaccines ,BACTERIAL vaccines - Abstract
The most effective measure to induce protection from influenza is vaccination. Thus, yearly vaccination is recommended, which, together with infections, establishes diverse repertoires of B cells, antibodies, and T cells. We examined the impact of this accumulated immunity on human responses in adults to split, subunit, and recombinant protein-based influenza vaccines. Enzyme-linked immunosorbent assay (ELISA) assays, to quantify serum antibodies, and peptide-stimulated CD4 T-cell cytokine ELISpots revealed that preexisting levels of hemagglutinin (HA)-specific antibodies were negatively associated with gains in antibody postvaccination, while preexisting levels of CD4 T cells were negatively correlated with vaccine-induced expansion of CD4 T cells. These patterns were seen independently of the vaccine formulation administered and the subjects' influenza vaccine history. Thus, although memory CD4 T cells and serum antibodies consist of components that can enhance vaccine responses, on balance, the accumulated immunity specific for influenza A H1 and H3 proteins is associated with diminished future responses. [ABSTRACT FROM AUTHOR]
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- 2023
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7. The Negative Effect of Preexisting Immunity on Influenza Vaccine Responses Transcends the Impact of Vaccine Formulation Type and Vaccination History
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Moritzky, Savannah A, primary, Richards, Katherine A, additional, Glover, Maryah A, additional, Krammer, Florian, additional, Chaves, Francisco A, additional, Topham, David J, additional, Branche, Angela, additional, Nayak, Jennifer L, additional, and Sant, Andrea J, additional
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- 2022
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- View/download PDF
8. Epiglottitis
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Nayak, Jennifer L., primary and Weinberg, Geoffrey A., additional
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- 2015
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9. Contributors
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Aagaard, Kjersti, primary, Abrahamian, Fredrick M., additional, Allos, Ban Mishu, additional, Andes, David R., additional, Aoki, Fred Y., additional, Apicella, Michael A., additional, Ard, Kevin L., additional, Arias, Cesar A., additional, Aronoff, David M., additional, Augenbraun, Michael H., additional, Averhoff, Francisco, additional, Azar, Dimitri T., additional, Baddour, Larry M., additional, Baden, Lindsey R., additional, Baker, Carol J., additional, Ballard, Ronald C., additional, Barber, Gerard R., additional, Barnes, Scott D., additional, Barouch, Dan H., additional, Barrett, Alan D., additional, Barshak, Miriam Baron, additional, Basavaraju, Sridhar V., additional, Batteiger, Byron E., additional, Baum, Stephen G., additional, Bayer, Arnold S., additional, Beckham, J. David, additional, Beekmann, Susan E., additional, Bell, Beth P., additional, Bennett, John E., additional, Bente, Dennis A., additional, Berbari, Elie F., additional, Berman, Jonathan, additional, Bertino, Joseph S., additional, Bhimraj, Adarsh, additional, Birdsall, Holly H., additional, Bisno, Alan L., additional, Blackburn, Brian G., additional, Blanton, Lucas S., additional, Blaser, Martin J., additional, Bleck, Thomas P., additional, Blijlevens, Nicole M.A., additional, Bobak, David A., additional, Bonnez, William, additional, Boothroyd, John C., additional, Borio, Luciana L., additional, Bosque, Patrick J., additional, Bower, John, additional, Bradsher, Robert W., additional, Brook, Itzhak, additional, Brown, Kevin E., additional, Brown, Patricia D., additional, Brown-Elliott, Barbara A., additional, Bruhn, Roberta L., additional, Bryant, Amy E., additional, Burd, Eileen M., additional, Burns, Jane C., additional, Bush, Larry M., additional, Calderwood, Stephen B., additional, Cano, Luz Elena, additional, Carpenter, Charles C.J., additional, Caserta, Mary T., additional, Castagnola, Elio, additional, Chaisson, Richard E., additional, Chambers, Henry F., additional, Chapman, Stephen J., additional, Chappell, James D., additional, Chen, Lea Ann, additional, Chen, Sharon C-A, additional, Chow, Anthony W., additional, Clark, Rebecca A., additional, Cohen, Jeffrey I., additional, Cohen, Myron S., additional, Cohen-Poradosu, Ronit, additional, Cohn, Susan E., additional, Connors, Mark, additional, Corey, Lawrence, additional, Cottrell, Mackenzie L., additional, Cover, Timothy L., additional, Cox, Heather L., additional, Craig, William A., additional, Crossley, Kent B., additional, Crumpacker, Clyde S., additional, Curran, James W., additional, Currie, Bart J., additional, D'Agata, Erika, additional, Damon, Inger K., additional, Darouiche, Rabih O., additional, DeBiasi, Roberta L., additional, Deepe, George S., additional, del Rio, Carlos, additional, Delemos, Andrew S., additional, DeLeo, Frank R., additional, DeMuri, Gregory P., additional, Densen, Peter, additional, Dermody, Terence S., additional, Dewar, Robin, additional, Diaz, James H., additional, Dieffenbach, Carl W., additional, Dienstag, Jules L., additional, Doi, Yohei, additional, Dolin, Raphael, additional, Donnelly, J. Peter, additional, Donnenberg, Michael S., additional, Donowitz, Gerald R., additional, Dormitzer, Philip R., additional, Drake, James M., additional, Dumler, J. Stephen, additional, Dummer, J. Stephen, additional, DuPont, Herbert L., additional, Durack, David T., additional, Durand, Marlene L., additional, Edelstein, Paul H., additional, Edmond, Michael B., additional, Edwards, John E., additional, Edwards, Morven S., additional, Eliopoulos, George M., additional, Ellison, Richard T., additional, Endy, Timothy P., additional, Engleberg, N. Cary, additional, Erdem, Hakan, additional, Ernst, Joel D., additional, Ernst, Peter B., additional, Fairhurst, Rick M., additional, Fairley, Jessica K., additional, Falkow, Stanley, additional, Falsey, Ann R., additional, Fauci, Anthony S., additional, Fekete, Thomas, additional, Fey, Paul D., additional, Fine, Steven M., additional, Fitzgerald, Daniel W., additional, Flores, Anthony R., additional, Forster, Derek, additional, Fowler, Vance G., additional, Freedman, David O., additional, Friedlander, Arthur M., additional, Galgiani, John N., additional, Gallin, John I., additional, Gallo, Robert C., additional, Gandhi, Tejal N., additional, Garrett, Wendy S., additional, Gaydos, Charlotte A., additional, Geisbert, Thomas W., additional, Gelfand, Jeffrey A., additional, Gelone, Steven P., additional, Gerding, Dale N., additional, Gershon, Anne A., additional, Gilsdorf, Janet R., additional, Goldstein, Ellie J.C., additional, Gordin, Fred M., additional, Graman, Paul S., additional, Grayson, M. Lindsay, additional, Greene, Jeffrey Bruce, additional, Griffin, Patricia M., additional, Griffith, David E., additional, Guerrant, Richard L., additional, Gul, H. Cem, additional, Haake, David A., additional, Haas, David W., additional, Haines, Charles, additional, Hall, Caroline Breese, additional, Hallak, Joelle, additional, Halperin, Scott A., additional, Hammerschlag, Margaret R., additional, Haque, Rashidul, additional, Harris, Jason B., additional, Hawkins, Claudia, additional, Hay, Roderick J., additional, Hedberg, Craig W., additional, Henderson, David K., additional, Henderson, Donald A., additional, High, Kevin P., additional, Hill, Adrian V.S., additional, Hill, David R., additional, Hinman, Alan R., additional, Hirsch, Martin S., additional, Hodowanec, Aimee, additional, Hohl, Tobias M., additional, Holland, Steven M., additional, Holzman, Robert S., additional, Hook, Edward W., additional, Hooper, David C., additional, Hooton, Thomas M., additional, Horowitz, Harold W., additional, Horsburgh, C. Robert, additional, Horton, James M., additional, Hospenthal, Duane R., additional, Hsueh, Kevin, additional, Hughes, James M., additional, Hynes, Noreen A., additional, Iovine, Nicole M., additional, Iredell, Jonathan R., additional, Ison, Michael G., additional, Janda, J. Michael, additional, Janoff, Edward N., additional, Johannsen, Eric C., additional, Kashuba, Angela D.M., additional, Kasper, Dennis L., additional, Kaye, Donald, additional, Kaye, Keith S., additional, Kaye, Kenneth M., additional, Kazura, James W., additional, Keystone, Jay S., additional, Khabbaz, Rima, additional, Khan, David A., additional, Khudyakov, Yury, additional, Kim, Rose, additional, King, Charles H., additional, Kirchhoff, Louis V., additional, Klein, Jerome O., additional, Klompas, Michael, additional, Knoll, Bettina M., additional, Knowlton, Kirk U., additional, Koehler, Jane E., additional, Kohlhoff, Stephan A., additional, Könönen, Eija, additional, Kontoyiannis, Dimitrios P., additional, Koralnik, Igor J., additional, Korpe, Poonum S., additional, Koshy, Anita A., additional, Kovacs, Joseph A., additional, Kozarsky, Phyllis, additional, Krieger, John, additional, Kroger, Andrew T., additional, Kuehnert, Matthew J., additional, Kumar, Nalin M., additional, Kuruvilla, Merin Elizabeth, additional, LaRocque, Regina C., additional, Leggett, James E., additional, Legido-Quigley, Helena, additional, Levett, Paul N., additional, Levine, Donald P., additional, Levison, Matthew E., additional, Levitt, Alexandra, additional, Lewis, Russell E., additional, Liles, W. Conrad, additional, Lima, Aldo A.M., additional, Limaye, Ajit P., additional, Lipkin, W. Ian, additional, Litman, Nathan, additional, Lorber, Bennett, additional, Luna, Ruth Ann, additional, MacDougall, Conan, additional, Roy, Rob, additional, Mackowiak, Philip A., additional, Madoff, Lawrence C., additional, Magill, Alan J., additional, Maguire, James H., additional, Maldarelli, Frank, additional, Markoff, Lewis, additional, Marrazzo, Jeanne M., additional, Marrie, Thomas J., additional, Marth, Thomas, additional, Martin, David H., additional, Martin, Gregory J., additional, Marty, Francisco M., additional, Maslow, Melanie Jane, additional, Masur, Henry, additional, Mawle, Alison, additional, Mayer, Kenneth H., additional, McBride, John T., additional, McCarthy, James S., additional, McCormack, William M., additional, McGowan, Catherine C., additional, McIntosh, Kenneth, additional, Mead, Paul S., additional, Mikulska, Malgorzata, additional, Miller, Robert F., additional, Miller, Samuel I., additional, Mitchell, David H., additional, Modlin, John F., additional, Mody, Rajal K., additional, Moellering, Robert C., additional, Moffa, Matthew, additional, Moir, Susan, additional, Montoya, José G., additional, Moore, Thomas A., additional, Moreillon, Philippe, additional, Morris, J. Glenn, additional, Morse, Caryn Gee, additional, Moseley, Robin, additional, Munford, Robert S., additional, Murphy, Edward L., additional, Murphy, Timothy F., additional, Murray, Barbara E., additional, Murray, Clinton K., additional, Murray, Patrick R., additional, Musher, Daniel M., additional, Nagel, Jerod L., additional, Nannini, Esteban C., additional, Narezkina, Anna, additional, Nash, Theodore E., additional, Nauseef, William M., additional, Nayak, Jennifer L., additional, Neill, Marguerite A., additional, O'Donnell, Judith A., additional, Ohl, Christopher A., additional, Okhuysen, Pablo C., additional, Onderdonk, Andrew B., additional, Opal, Steven M., additional, Orenstein, Walter A., additional, Osmon, Douglas R., additional, Osterholm, Michael T., additional, Ostroff, Stephen M., additional, Oxman, Michael N., additional, Paessler, Slobodan, additional, Page, Andrea V., additional, Pai, Manjunath P., additional, Palmore, Tara N., additional, Palraj, Raj, additional, Pappas, Peter G., additional, Pasternack, Mark S., additional, Patterson, Thomas F., additional, Pavan-Langston, Deborah, additional, Pegues, David A., additional, Penn, Robert L., additional, Perfect, John R., additional, Perlman, Stanley, additional, Petersen, Brett W., additional, Peterson, Phillip K., additional, Petri, William A., additional, Petti, Cathy A., additional, Philips, Jennifer A., additional, Philley, Julie V., additional, Phillips, Michael, additional, Pickering, Larry K., additional, Piot, Peter, additional, Pogue, Jason M., additional, Pop-Vicas, Aurora, additional, Portal-Celhay, Cynthia, additional, Powers, John H., additional, Price, Richard N., additional, Que, Yok-Ai, additional, Radolf, Justin D., additional, Ram, Sanjay, additional, Raoult, Didier, additional, Ravdin, Jonathan I., additional, Ray, Stuart C., additional, Reboli, Annette C., additional, Reitz, Marvin S., additional, Relman, David A., additional, Renault, Cybèle A., additional, Restrepo, Angela, additional, Rex, John H., additional, Rhee, Elizabeth G., additional, Roberts, Norbert J., additional, Romero, José R., additional, Rothman, Alan L., additional, Roy, Craig R., additional, Ruoff, Kathryn L., additional, Rupp, Mark E., additional, Rupprecht, Charles E., additional, Russo, Thomas A., additional, Rutala, William A., additional, Ryan, Edward T., additional, Safdar, Amar, additional, Sajadi, Mohammad M., additional, Salazar, Juan C., additional, Sarria, Juan Carlos, additional, Savoia, Maria C., additional, Sax, Paul E., additional, Scheld, W. Michael, additional, Schiffer, Joshua T., additional, Schlossberg, David, additional, Schneider, Thomas, additional, Schuchat, Anne, additional, Schwebke, Jane R., additional, Sears, Cynthia L., additional, Segal, Leopoldo N., additional, Sendi, Parham, additional, Sepkowitz, Kent A., additional, Septimus, Edward J., additional, Seregin, Alexey, additional, Shulman, Stanford T., additional, Siberry, George K., additional, Siddiqi, Omar K., additional, Sifri, Costi D., additional, Simberkoff, Michael S., additional, Simonetti, Francesco R., additional, Singh, Kamaljit, additional, Singh, Nina, additional, Singh, Upinder, additional, Sinner, Scott W., additional, Sivapalasingam, Sumathi, additional, Slater, Leonard N., additional, Smulian, A. George, additional, Sobel, Jack D., additional, Sohail, M. Rizwan, additional, Soper, David E., additional, Sorrell, Tania C., additional, Steckelberg, James M., additional, Steere, Allen C., additional, Steigbigel, Neal H., additional, Steinberg, James P., additional, Stephens, David S., additional, Sterling, Timothy R., additional, Stevens, David A., additional, Stevens, Dennis L., additional, Strahilevitz, Jacob, additional, Stratton, Charles W., additional, Suffredini, Anthony F., additional, Suh, Kathryn N., additional, Sulkowski, Mark S., additional, Swartz, Morton N., additional, Talbot, Thomas R., additional, Tan, C. Sabrina, additional, Tan, Ming, additional, Thio, Chloe Lynne, additional, Thomas, David L., additional, Thomas, Lora D., additional, Thomas, Stephen J., additional, Thorner, Anna R., additional, María Tobón, Angela, additional, Tramont, Edmund C., additional, Treanor, John J., additional, Trubiano, Jason, additional, Tsibris, Athe M.N., additional, Tunkel, Allan R., additional, Turner, Ronald B., additional, Tyler, Kenneth L., additional, Uluer, Ahmet, additional, van de Beek, Diederik, additional, van der Velden, Walter J.F.M., additional, Vannier, Edouard G., additional, Van, Trevor C., additional, Versalovic, James, additional, Viscoli, Claudio, additional, Wald, Ellen R., additional, Waldor, Matthew K., additional, Walker, David H., additional, Wallace, Richard J., additional, Walsh, Edward E., additional, Walsh, Stephen R., additional, Walzer, Peter D., additional, Wanke, Christine A., additional, Warren, Cirle A., additional, Washburn, Ronald G., additional, Waters, Valerie, additional, Weber, David J., additional, Weiden, Michael D., additional, Weinberg, Geoffrey A., additional, Weisdorf, Daniel J., additional, Weiss, Louis M., additional, Welch, David F., additional, Wellems, Thomas E., additional, Wenzel, Richard P., additional, Wharton, Melinda, additional, White, A. Clinton, additional, Whitley, Richard J., additional, Wilson, Walter R., additional, Wortmann, Glenn W., additional, Wright, William F., additional, Young, Jo-Anne H., additional, Young, Vincent B., additional, Yun, Nadezhda, additional, Zimmerli, Werner, additional, Zinner, Stephen H., additional, and Zurlo, John J., additional
- Published
- 2015
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- View/download PDF
10. 63 - Epiglottitis
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Nayak, Jennifer L. and Weinberg, Geoffrey A.
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- 2020
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11. Differences in Influenza-Specific CD4 T-Cell Mediated Immunity Following Acute Infection Versus Inactivated Vaccination in Children
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Shannon, Ian, primary, White, Chantelle L, additional, Yang, Hongmei, additional, and Nayak, Jennifer L, additional
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- 2020
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12. Loss in CD4 T-cell responses to multiple epitopes in influenza due to expression of one additional MHC class II molecule in the host
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Nayak, Jennifer L. and Sant, Andrea J.
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- 2012
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13. Understanding Immunity in Children Vaccinated With Live Attenuated Influenza Vaccine
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Shannon, Ian, primary, White, Chantelle L, primary, and Nayak, Jennifer L, primary
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- 2019
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14. The Importance of Vaccinating Children and Pregnant Women against Influenza Virus Infection
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Misra, Ravi S, primary and Nayak, Jennifer L, additional
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- 2019
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15. Differences in Influenza-Specific CD4 T-Cell Mediated Immunity Following Acute Infection Versus Inactivated Vaccination in Children.
- Author
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Shannon, Ian, White, Chantelle L, Yang, Hongmei, and Nayak, Jennifer L
- Subjects
VACCINATION of children ,CLINICAL trial registries ,IMMUNOLOGIC memory ,IMMUNITY ,ANTIBODY specificity ,PSYCHONEUROIMMUNOLOGY ,BCG vaccines ,INFLUENZA prevention ,INFLUENZA vaccines ,IMMUNIZATION ,VACCINES ,RESEARCH funding ,T cells ,CELLULAR immunity ,INFLUENZA A virus, H3N2 subtype - Abstract
Background: Early childhood influenza infections imprint influenza-specific immune memory, with most studies evaluating antibody specificity. In this study, we examined how infection versus inactivated influenza vaccination (IIV) establish pediatric CD4 T-cell mediated immunity to influenza and whether this poises the immune system to respond differently to IIV the following year.Methods: We tracked influenza-specific CD4 T-cell responses in 16 H3N2 infected and 28 IIV immunized children following both initial exposure and after cohorts were revaccinated with IIV the following fall. PBMCs were stimulated with peptide pools encompassing the translated regions of the H3 HA and NP proteins and were then stained to assess CD4 T-cell specificity and function.Results: Compared to IIV, infection primed a greater magnitude CD4 T-cell response specific for the infecting HA and NP proteins, with more robust NP-specific immunity persisting through year 2. Post infection, CD4 T cells preferentially produced combinations of cytokines that included interferon-γ. Interestingly, age-specific patterns in CD4 T-cell reactivity demonstrated the impact of multiple influenza exposures over time.Conclusions: These data indicate that infection and vaccination differentially prime influenza-specific CD4 T-cell responses in early childhood, with these differences contributing to the lasting immunologic imprinting established following early influenza infection.Clinical Trials Registration: NCT02559505. [ABSTRACT FROM AUTHOR]- Published
- 2021
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16. Evidence That Blunted CD4 T-Cell Responses Underlie Deficient Protective Antibody Responses to Influenza Vaccines in Repeatedly Vaccinated Human Subjects
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Richards, Katherine A, primary, Shannon, Ian, additional, Treanor, John J, additional, Yang, Hongmei, additional, Nayak, Jennifer L, additional, and Sant, Andrea J, additional
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- 2019
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17. Colaboradores
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Aagaard, Kjersti, Abdallah, Marie, Abrahamian, Fredrick M., Agnihotri, Shruti, Ahmed, Sana S., Allos, Ban Mishu, Alqahtani, Saleh A., Anderson, Jeffrey L., Andes, David R., Andrews, Jason R., Aoki, Fred Y., Apicella, Michael A., Araos, Rafael, Ard, Kevin L., Arias, Cesar A., Aronoff, David M., Aronson, Naomi E., Augenbraun, Michael H., Auwaerter, Paul G., Averhoff, Francisco, Azar, Dimitri T., Babu, Tara M., Bachmann, Laura Hinkle, Baddour, Larry M., Baden, Lindsey R., Baker, Carol J., Ballard, Sarah-Blythe, Barber, Gerard R., Barnes, Scott D., Barouch, Dan H., Barrett, Alan D., Barshak, Miriam Baron, Bartelt, Luther A., Basavaraju, Sridhar V., Batteiger, Byron E., Baum, Stephen G., Bayer, Arnold S., Beckham, J. David, Beekmann, Susan E., Beigi, Richard H., Bennett, John E., Berbari, Elie F., Bertino, Joseph S., Jr., Bhimraj, Adarsh, Birch, Torrey Boland, Birdsall, Holly H., Blackburn, Brian G., Blanton, Lucas S., Blaser, Martin J., Blazes, David L., Bleck, Thomas P., Blijlevens, Nicole M.A., Blyth, Dana M., Boggild, Andrea K., Bogoch, Isaac I., Bonnez, William, Boothroyd, John C., Borio, Luciana L., Bosque, Patrick J., Braden, Christopher R., Branche, Angela R., Britt, William J., Brook, Itzhak, Brouwer, Matthijs C., Brown, Kevin E., Brown, Patricia, Brown-Elliott, Barbara A., Bruhn, Roberta L., Bryant, Amy E., Burd, Eileen M., Burns, Jane C., Bush, Larry M., Casadevall, Arturo, Caserta, Mary T., Castagnola, Elio, Chaisson, Richard E., Chapman, Stephen J., Chappell, Catherine A., Chappell, James D., Chen, Lea Ann, Chen, Sharon C-A., Chiang, Augusto Dulanto, Chopra, Sanjiv, Chow, Anthony W., Clancy, Cornelius J., Clark, Richard B., Cohen, Jeffrey I., Cohen, Myron S., Cohen, Yehuda Z., Cohen-Poradosu, Ronit, Cohn, Susan E., Colton, Benjamin, Connors, Mark, Copeland, Nathanial K., Corey, Lawrence, Cosgrove, Sara E., Cottrell, Mackenzie L., Cover, Timothy L., Cox, Heather L., Crass, Ryan L., Cunha, Cheston B., Curran, James W., Currie, Bart J., D’Agata, Erika, Daly, Jennifer S., Damon, Inger K., Darouiche, Rabih O., Dawid, Suzanne, Deepe, George S., Jr., Dekker, John P., del Rio, Carlos, DeLeo, Frank R., DeMuri, Gregory P., Dermody, Terence S., Dewar, Robin, Diaz, James H., Dieffenbach, Carl W., Dienstag, Jules L., Doi, Yohei, Dolin, Raphael, Donowitz, Gerald R., Donskey, Curtis J., Dormitzer, Philip R., Dumler, J. Stephen, Dupnik, Kathryn, DuPont, Herbert L., Durack, David T., Durand, Marlene L., Duval, Xavier, Edelstein, Paul H., Edwards, John E., Jr., Edwards, Morven S., Ellison, Richard T., III, Embry, Alan C., Endy, Timothy P., Engleberg, N. Cary, Englund, Janet A., Erdem, Hakan, Ernst, Peter B., Fairhurst, Rick M., Fairley, Jessica K., Falkow, Stanley, Falsey, Ann R., Fauci, Anthony S., Fekete, Thomas, Fey, Paul D., Fine, Steven M., Fitzgerald, Daniel W., Flores, Anthony R., Fournier, Pierre-Edouard, Fowler, Vance G., Jr., Freedman, David O., Friedlander, Arthur M., Galgiani, John N., Gallin, John I., Gallo, Robert C., Gandhi, Monica, Garrett, Wendy S., Gauthier, Gregory M., Gaydos, Charlotte A., Gea-Banacloche, Juan C., Geisbert, Thomas W., Gelfand, Jeffrey A., Gelone, Steven P., Gerding, Dale N., Gershon, Anne A., Gilsdorf, Janet R., Giri, Pushpanjali, Gold, Howard S., Goldstein, Ellie J.C., González-Marín, Ángel, Graman, Paul S., Grayson, M. Lindsay, Greenberg, David, Greene, Matthew H., Griffin, Patricia M., Griffith, David E., Guerrant, Richard L., Gul, Hanefi C., Haake, David A., Haas, David W., Haidar, Ghady, Hallak, Joelle, Halperin, Scott A., Hammerschlag, Margaret R., Haque, Rashidul, Harris, Jason B., Hartzell, Joshua D., Hasbun, Rodrigo, Hawkins, Claudia, Hay, Roderick J., Henderson, David K., High, Kevin P., Hill, Adrian V.S., Hinman, Alan R., Hirsch, Martin S., Hochman, Sarah, Hoen, Bruno, Hohl, Tobias M., Holland, Steven M., Holland, Thomas L., Holzman, Robert S., Hooper, David C., Hooton, Thomas M., Hoover, Susan E., Horowitz, Harold W., Horton, James M., Hospenthal, Duane R., Hotez, Peter J., Hynes, Noreen A., Iovine, Nicole M., Ison, Michael G., Jaggi, Preeti, Janda, J. Michael, Janoff, Edward N., Jernigan, Daniel, Johannsen, Eric C., Johnson, Jennie E., Juliano, Jonathan J., Kamboj, Mini, Kasper, Dennis L., Kaye, Donald, Kaye, Keith S., Kaye, Kenneth M., Kazura, James W., Keystone, Jay S., Khabbaz, Rima F., Khan, David A., Khudyakov, Yury, Kim, Rose, King, Charles H., Kirchhoff, Louis V., Kirkpatrick, Beth D., Kiyono, Hiroshi, Klein, Bruce S., Klompas, Michael, Knoll, Bettina M., Knowlton, Kirk U., Koehler, Jane E., Kohlhoff, Stephan A., Könönen, Eija, Kontoyiannis, Dimitrios P., Koralnik, Igor J., Korpe, Poonum S., Koshy, Anita A., Kovacs, Joseph A., Kroger, Andrew T., Kuehnert, Matthew J., Kumar, Nalin M., Kuruvilla, Merin Elizabeth, LaRocque, Regina C., LaSalvia, Mary T., Leaf, Howard L., Leggett, James E., Lepak, Alexander J., Levett, Paul N., Levine, Donald P., Levison, Matthew E., Levitt, Alexandra, Lewis, Russell E., Liles, W. Conrad, Lima, Aldo A.M., Limaye, Ajit P., Lionakis, Michail S., Lipkin, W. Ian, Litman, Nathan, Luna, Ruth Ann, Lutgring, Joseph D., MacDougall, Conan, Maddocks, Susan, Madoff, Lawrence C., Magill, Alan J., Maguire, James H., Maldarelli, Frank, Markoff, Lewis, Marrazzo, Jeanne M., Marrie, Thomas J., Marth, Thomas, Martin, David H., Martin, Gregory J., Marty, Francisco M., Maslow, Melanie Jane, Masur, Henry, Mawle, Alison, Mayer, Kenneth H., McCarthy, James S., McCormack, William, McGowan, Catherine C., McIntosh, Kenneth, Mead, Paul S., Mejia, Rojelio, Mekala, Vijayashree, Messonnier, Nancy, Mikulska, Małgorzata, Miller, Robert F., Miller, Samuel I., Miller, William R., Moffa, Matthew, Moir, Susan, Montoya, José G., Moonah, Shannon N., Moore, Thomas A., Moreillon, Philippe, Morgan, Janet, Morris, J. Glenn, Jr., Munita, Jose M., Murphy, Edward L., Murphy, Timothy F., Murray, Barbara E., Murray, Clinton K., Musher, Daniel M., Mylonakis, Eleftherios, Nagel, Jerod L., Naggie, Susanna, Nannini, Esteban C., Nash, Theodore E., Nauseef, William M., Nayak, Jennifer L., Neill, Marguerite A., Nelson, George E., Nelson, Joanna K., Nesbitt, Whitney J., Nguyen, M. Hong, O’Donnell, Judith A., Ohl, Christopher A., Okhuysen, Pablo C., Onderdonk, Andrew B., Opal, Steven M., Orenstein, Walter A., Osmon, Douglas R., Oxman, Michael N., Paessler, Slobodan, Page, Andrea V., Pai, Manjunath P., Palmore, Tara N., Palraj, Raj, Pappas, Peter G., Paris, Daniel H., Parks, Tom, Parsonnet, Julie, Parta, Mark, Pasternack, Mark S., Pastula, Daniel M., Patel, Robin, Patterson, Thomas F., Pavan-Langston, Deborah, Pegues, David A., Pelton, Stephen I., Penn, Robert L., Perfect, John R., Perkins, Ryan, Perlman, Stanley, Petersen, Brett W., Petri, William A., Jr., Petti, Cathy A., Philips, Jennifer A., Philley, Julie V., Phillips, Michael, Pickering, Larry K., Piot, Peter, Pogue, Jason M., Polsky, Bruce, Pop-Vicas, Aurora, Portal-Celhay, Cynthia, Powers, John H., III, Price, Richard N., Que, Yok-Ai, Radolf, Justin D., Ram, Sanjay, Ramakrishnan, Lalita, Raoult, Didier, Ravdin, Jonathan I., Reboli, Annette C., Redel, Henry, Reitz, Marvin S., Jr., Relman, David A., Reno, Hilary E.L., Restrepo-Moreno, Ángela, Rex, John H., Rhee, Elizabeth G., Roberts, Norbert J., Jr., Romanovsky, Andrej A., Romero, José R., Rose, Stacey R., Rosenberg, Ronald, Rothman, Alan L., Roy, Craig R., Ruoff, Kathryn L., Rupp, Mark E., Rupprecht, Charles E., Russo, Thomas A., Rutala, William A., Ryan, Edward T., Sajadi, Mohammad M., Salazar, Juan C., Saleeb, Paul G., Sarria, Juan Carlos, Savoia, Maria C., Sax, Paul E., Schiffer, Joshua T., Schlossberg, David, Schneider, Thomas, Schwebke, Jane R., Sears, Cynthia L., Segal, Leopoldo N., Sendi, Parham, Sepkowitz, Kent A., Seregin, Alexey, Shulman, Stanford T., Siberry, George K., Siddiqi, Omar K., Sifri, Costi D., Simberkoff, Michael S., Simonetti, Francesco, Singh, Nina, Singh, Upinder, Smulian, A. George, Sobel, Jack D., Sohail, M. Rizwan, Sorrell, Tania C., Spellberg, Brad, Steckelberg, James M., Steere, Allen C., Steinberg, James P., Stephens, David S., Stephenson, Kathryn E., Sterling, Timothy R., Stevens, David A., Stevens, Dennis L., Stoner, Bradley P., Strahilevitz, Jacob, IV, Charles W. Stratton, Strnad, Luke C., Suh, Kathryn N., Sulkowski, Mark S., Swartz, Morton N., Talati, Naasha J., Talbot, Thomas R., Tan, C. Sabrina, Tan, Ming, Tande, Aaron J., Tesini, Brenda L., Thio, Chloe Lynne, Thomas, Stephen J., Thompson, George R., III, Thorner, Anna R., Tobón-Orozco, Ángela Ma., Tramont, Edmund C., Trautner, Barbara W., Treanor, John J., Trivedi, Hirsh D., Trubiano, Jason, Tsibris, Athe M.N., Tunkel, Allan R., Tyler, Kenneth L., Uluer, Ahmet Z., Urban, Marguerite A., Ustun, Celalettin, Uyeki, Timothy M., van de Beek, Diederik, van der Poll, Tom, van der Velden, Walter J.F.M., Van Schooneveld, Trevor C., Vannier, Edouard, Vellozzi, Claudia, Versalovic, James, Vijayan, Vini, Viscoli, Claudio, Wald, Ellen R., Waldor, Matthew K., Walker, David H., Wallace, Richard J., Jr., Walsh, Edward E., Walsh, Stephen R., Walzer, Peter D., Wanke, Christine A., Ward, Honorine D., Warren, Cirle A., Washburn, Ronald G., Waters, Valerie, Watkins, Richard R., Watts, Matthew R., Weatherhead, Jill, Weber, David J., Weiden, Michael D., Weinberg, Geoffrey A., Weiss, Louis M., Wellems, Thomas E., White, A. Clinton, Jr., Whitley, Richard J., Wiersinga, Willem Joost, Williams, Brett, Wilson, Walter R., Winslow, Dean L., Winthrop, Kevin L., Wong, Karen K., Wortmann, Glenn W., Wright, William F., Wyles, David L., Young, Jo-Anne H., Young, Vincent Bensan, Yun, Nadezhda, Zimmerli, Werner, Zinner, Stephen H., and Zurlo, John J.
- Published
- 2021
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18. 63 - Epiglotitis
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Nayak, Jennifer L. and Weinberg, Geoffrey A.
- Published
- 2021
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19. Evidence That Blunted CD4 T-Cell Responses Underlie Deficient Protective Antibody Responses to Influenza Vaccines in Repeatedly Vaccinated Human Subjects.
- Author
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Richards, Katherine A, Shannon, Ian, Treanor, John J, Yang, Hongmei, Nayak, Jennifer L, and Sant, Andrea J
- Abstract
Despite the benefits of yearly influenza vaccination, accumulating evidence suggests that diminished vaccine efficacy may be related to repeated vaccination. Although studied at the level of B-cell responses, CD4 T-cell responses have not yet been examined. In this study, we analyze CD4 T-cell responses to influenza vaccination in subjects who differ in their vaccine history. We find a striking disparity in their responses, with previously vaccinated subjects exhibiting significantly blunted CD4 T-cell responses and diminished antibody responses. These results suggest that limiting CD4 T-cell help mteaserrlie the diminished or altered antibody responses in repeatedly vaccinated subjects. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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20. Understanding Immunity in Children Vaccinated With Live Attenuated Influenza Vaccine.
- Author
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Shannon, Ian, White, Chantelle L, and Nayak, Jennifer L
- Subjects
INTRANASAL medication ,IMMUNE system ,INFLUENZA vaccines ,RESPIRATORY infections ,VIRAL physiology ,PHARMACODYNAMICS ,CHILDREN - Abstract
Live attenuated influenza vaccine (LAIV), or FluMist, was approved for use in the United States in 2003. This vaccine, administered intranasally, offers the advantage of stimulating immunity at the site of infection in the upper respiratory tract and, by mimicking natural infection, has the potential to elicit a multifaceted immune response. However, the development of immunity following LAIV administration requires viral replication, causing vaccine effectiveness to be impacted by both the replicative fitness of the attenuated viruses being administered and the degree of the host's preexisting immunity. In this review, we discuss the current state of knowledge regarding the mechanisms of protection elicited by LAIV in children, contrast this with immune protection that develops upon vaccination with inactivated influenza vaccines, and briefly discuss both the potential advantages as well as challenges offered by this vaccination platform. [ABSTRACT FROM AUTHOR]
- Published
- 2020
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21. CD4 T cells in protection from influenza virus: Viral antigen specificity and functional potential
- Author
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Sant, Andrea J., primary, DiPiazza, Anthony T., additional, Nayak, Jennifer L., additional, Rattan, Ajitanuj, additional, and Richards, Katherine A., additional
- Published
- 2018
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22. Contributors
- Author
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Aagaard, Kjersti, Abdallah, Marie, Abrahamian, Fredrick M., Agnihotri, Shruti, Ahmed, Sana S., Allos, Ban Mishu, Alqahtani, Saleh A., Anderson, Jeffrey L., Andes, David R., Andrews, Jason R., Aoki, Fred Y., Apicella, Michael A., Araos, Rafael, Ard, Kevin L., Arias, Cesar A., Aronoff, David M., Aronson, Naomi E., Augenbraun, Michael H., Auwaerter, Paul G., Averhoff, Francisco, Azar, Dimitri T., Babu, Tara M., Bachmann, Laura Hinkle, Baddour, Larry M., Baden, Lindsey R., Baker, Carol J., Ballard, Sarah-Blythe, Barber, Gerard R., Barnes, Scott D., Barouch, Dan H., Barrett, Alan D., Barshak, Miriam Baron, Bartelt, Luther A., Basavaraju, Sridhar V., Batteiger, Byron E., Baum, Stephen G., Bayer, Arnold S., Beckham, J. David, Beekmann, Susan E., Beigi, Richard H., Bennett, John E., Berbari, Elie F., Bertino, Joseph S., Jr., Bhimraj, Adarsh, Birch, Torrey Boland, Birdsall, Holly H., Blackburn, Brian G., Blanton, Lucas S., Blaser, Martin J., Blazes, David L., Bleck, Thomas P., Blijlevens, Nicole M.A., Blyth, Dana M., Boggild, Andrea K., Bogoch, Isaac I., Bonnez, William, Boothroyd, John C., Borio, Luciana L., Bosque, Patrick J., Braden, Christopher R., Branche, Angela R., Britt, William J., Brook, Itzhak, Brouwer, Matthijs C., Brown, Kevin E., Brown, Patricia, Brown-Elliott, Barbara A., Bruhn, Roberta L., Bryant, Amy E., Burd, Eileen M., Burns, Jane C., Bush, Larry M., Casadevall, Arturo, Caserta, Mary T., Castagnola, Elio, Chaisson, Richard E., Chapman, Stephen J., Chappell, Catherine A., Chappell, James D., Chen, Lea Ann, Chen, Sharon C-A., Chiang, Augusto Dulanto, Chopra, Sanjiv, Chow, Anthony W., Clancy, Cornelius J., Clark, Richard B., Cohen, Jeffrey I., Cohen, Myron S., Cohen, Yehuda Z., Cohen-Poradosu, Ronit, Cohn, Susan E., Colton, Benjamin, Connors, Mark, Copeland, Nathanial K., Corey, Lawrence, Cosgrove, Sara E., Cottrell, Mackenzie L., Cover, Timothy L., Cox, Heather L., Crass, Ryan L., Cunha, Cheston B., Curran, James W., Currie, Bart J., D'Agata, Erika, Daly, Jennifer S., Damon, Inger K., Darouiche, Rabih O., Dawid, Suzanne, Deepe, George S., Jr., Dekker, John P., del Rio, Carlos, DeLeo, Frank R., DeMuri, Gregory P., Dermody, Terence S., Dewar, Robin, Diaz, James H., Dieffenbach, Carl W., Dienstag, Jules L., Doi, Yohei, Dolin, Raphael, Donowitz, Gerald R., Donskey, Curtis J., Dormitzer, Philip R., Dumler, J. Stephen, Dupnik, Kathryn, DuPont, Herbert L., Durack, David T., Durand, Marlene L., Duval, Xavier, Edelstein, Paul H., Edwards, John E., Jr., Edwards, Morven S., Ellison, Richard T., III, Embry, Alan C., Endy, Timothy P., Engleberg, N. Cary, Englund, Janet A., Erdem, Hakan, Ernst, Peter B., Fairhurst, Rick M., Fairley, Jessica K., Falkow, Stanley, Falsey, Ann R., Fauci, Anthony S., Fekete, Thomas, Fey, Paul D., Fine, Steven M., Fitzgerald, Daniel W., Flores, Anthony R., Fournier, Pierre-Edouard, Fowler, Vance G., Jr., Freedman, David O., Friedlander, Arthur M., Galgiani, John N., Gallin, John I., Gallo, Robert C., Gandhi, Monica, Garrett, Wendy S., Gauthier, Gregory M., Gaydos, Charlotte A., Gea-Banacloche, Juan C., Geisbert, Thomas W., Gelfand, Jeffrey A., Gelone, Steven P., Gerding, Dale N., Gershon, Anne A., Gilsdorf, Janet R., Giri, Pushpanjali, Gold, Howard S., Goldstein, Ellie J.C., González-Marín, Ángel, Graman, Paul S., Grayson, M. Lindsay, Greenberg, David, Greene, Matthew H., Griffin, Patricia M., Griffith, David E., Guerrant, Richard L., Gul, Hanefi C., Haake, David A., Haas, David W., Haidar, Ghady, Hallak, Joelle, Halperin, Scott A., Hammerschlag, Margaret R., Haque, Rashidul, Harris, Jason B., Hartzell, Joshua D., Hasbun, Rodrigo, Hawkins, Claudia, Hay, Roderick J., Henderson, David K., High, Kevin P., Hill, Adrian V.S., Hinman, Alan R., Hirsch, Martin S., Hochman, Sarah, Hoen, Bruno, Hohl, Tobias M., Holland, Steven M., Holland, Thomas L., Holzman, Robert S., Hooper, David C., Hooton, Thomas M., Hoover, Susan E., Horowitz, Harold W., Horton, James M., Hospenthal, Duane R., Hotez, Peter J., Hynes, Noreen A., Iovine, Nicole M., Ison, Michael G., Jaggi, Preeti, Janda, J. Michael, Janoff, Edward N., Jernigan, Daniel, Johannsen, Eric C., Johnson, Jennie E., Juliano, Jonathan J., Kamboj, Mini, Kasper, Dennis L., Kaye, Donald, Kaye, Keith S., Kaye, Kenneth M., Kazura, James W., Keystone, Jay S., Khabbaz, Rima F., Khan, David A., Khudyakov, Yury, Kim, Rose, King, Charles H., Kirchhoff, Louis V., Kirkpatrick, Beth D., Kiyono, Hiroshi, Klein, Bruce S., Klompas, Michael, Knoll, Bettina M., Knowlton, Kirk U., Koehler, Jane E., Kohlhoff, Stephan A., Könönen, Eija, Kontoyiannis, Dimitrios P., Koralnik, Igor J., Korpe, Poonum S., Koshy, Anita A., Kovacs, Joseph A., Kroger, Andrew T., Kuehnert, Matthew J., Kumar, Nalin M., Kuruvilla, Merin Elizabeth, LaRocque, Regina C., LaSalvia, Mary T., Leaf, Howard L., Leggett, James E., Lepak, Alexander J., Levett, Paul N., Levine, Donald P., Levison, Matthew E., Levitt, Alexandra, Lewis, Russell E., Liles, W. Conrad, Lima, Aldo A.M., Limaye, Ajit P., Lionakis, Michail S., Lipkin, W. Ian, Litman, Nathan, Luna, Ruth Ann, Lutgring, Joseph D., MacDougall, Conan, Maddocks, Susan, Madoff, Lawrence C., Magill, Alan J., Maguire, James H., Maldarelli, Frank, Markoff, Lewis, Marrazzo, Jeanne M., Marrie, Thomas J., Marth, Thomas, Martin, David H., Martin, Gregory J., Marty, Francisco M., Maslow, Melanie Jane, Masur, Henry, Mawle, Alison, Mayer, Kenneth H., McCarthy, James S., McCormack, William, McGowan, Catherine C., McIntosh, Kenneth, Mead, Paul S., Mejia, Rojelio, Mekala, Vijayashree, Messonnier, Nancy, Mikulska, Małgorzata, Miller, Robert F., Miller, Samuel I., Miller, William R., Moffa, Matthew, Moir, Susan, Montoya, José G., Moonah, Shannon N., Moore, Thomas A., Moreillon, Philippe, Morgan, Janet, Morris, J. Glenn, Jr., Munita, Jose M., Murphy, Edward L., Murphy, Timothy F., Murray, Barbara E., Murray, Clinton K., Musher, Daniel M., Mylonakis, Eleftherios, Nagel, Jerod L., Naggie, Susanna, Nannini, Esteban C., Nash, Theodore E., Nauseef, William M., Nayak, Jennifer L., Neill, Marguerite A., Nelson, George E., Nelson, Joanna K., Nesbitt, Whitney J., Nguyen, M. Hong, O'Donnell, Judith A., Ohl, Christopher A., Okhuysen, Pablo C., Onderdonk, Andrew B., Opal, Steven M., Orenstein, Walter A., Osmon, Douglas R., Oxman, Michael N., Paessler, Slobodan, Page, Andrea V., Pai, Manjunath P., Palmore, Tara N., Palraj, Raj, Pappas, Peter G., Paris, Daniel H., Parks, Tom, Parsonnet, Julie, Parta, Mark, Pasternack, Mark S., Pastula, Daniel M., Patel, Robin, Patterson, Thomas F., Pavan-Langston, Deborah, Pegues, David A., Pelton, Stephen I., Penn, Robert L., Perfect, John R., Perkins, Ryan, Perlman, Stanley, Petersen, Brett W., Petri, William A., Jr., Petti, Cathy A., Philips, Jennifer A., Philley, Julie V., Phillips, Michael, Pickering, Larry K., Piot, Peter, Pogue, Jason M., Polsky, Bruce, Pop-Vicas, Aurora, Portal-Celhay, Cynthia, Powers, John H., III, Price, Richard N., Que, Yok-Ai, Radolf, Justin D., Ram, Sanjay, Ramakrishnan, Lalita, Raoult, Didier, Ravdin, Jonathan I., Reboli, Annette C., Redel, Henry, Reitz, Marvin S., Jr., Relman, David A., Reno, Hilary E.L., Restrepo-Moreno, Ángela, Rex, John H., Rhee, Elizabeth G., Roberts, Norbert J., Jr., Romanovsky, Andrej A., Romero, José R., Rose, Stacey R., Rosenberg, Ronald, Rothman, Alan L., Roy, Craig R., Ruoff, Kathryn L., Rupp, Mark E., Rupprecht, Charles E., Russo, Thomas A., Rutala, William A., Ryan, Edward T., Sajadi, Mohammad M., Salazar, Juan C., Saleeb, Paul G., Sarria, Juan Carlos, Savoia, Maria C., Sax, Paul E., Schiffer, Joshua T., Schlossberg, David, Schneider, Thomas, Schwebke, Jane R., Sears, Cynthia L., Segal, Leopoldo N., Sendi, Parham, Sepkowitz, Kent A., Seregin, Alexey, Shulman, Stanford T., Siberry, George K., Siddiqi, Omar K., Sifri, Costi D., Simberkoff, Michael S., Simonetti, Francesco, Singh, Nina, Singh, Upinder, Smulian, A. George, Sobel, Jack D., Sohail, M. Rizwan, Sorrell, Tania C., Spellberg, Brad, MD, Steckelberg, James M., Steere, Allen C., Steinberg, James P., Stephens, David S., Stephenson, Kathryn E., Sterling, Timothy R., Stevens, David A., Stevens, Dennis L., Stoner, Bradley P., Strahilevitz, Jacob, Stratton, Charles W., IV, Strnad, Luke C., Suh, Kathryn N., Sulkowski, Mark S., Swartz, Morton N., Talati, Naasha J., Talbot, Thomas R., Tan, C. Sabrina, Tan, Ming, Tande, Aaron J., Tesini, Brenda L., Thio, Chloe Lynne, Thomas, Stephen J., Thompson, George R., III, Thorner, Anna R., Tobón-Orozco, Ángela Ma., Tramont, Edmund C., Trautner, Barbara W., Treanor, John J., Trivedi, Hirsh D., Trubiano, Jason, Tsibris, Athe M.N., Tunkel, Allan R., Tyler, Kenneth L., Uluer, Ahmet Z., Urban, Marguerite A., Ustun, Celalettin, Uyeki, Timothy M., van de Beek, Diederik, van der Poll, Tom, van der Velden, Walter J.F.M., Van, Trevor C., Vannier, Edouard, Vellozzi, Claudia, Versalovic, James, Vijayan, Vini, Viscoli, Claudio, Wald, Ellen R., Waldor, Matthew K., Walker, David H., Wallace, Richard J., Jr., Walsh, Edward E., Walsh, Stephen R., Walzer, Peter D., Wanke, Christine A., Ward, Honorine D., Warren, Cirle A., Washburn, Ronald G., Waters, Valerie, Watkins, Richard R., Watts, Matthew R., Weatherhead, Jill, Weber, David J., Weiden, Michael D., Weinberg, Geoffrey A., Weiss, Louis M., Wellems, Thomas E., White, A. Clinton, Jr., Whitley, Richard J., Wiersinga, Willem Joost, Williams, Brett, Wilson, Walter R., Winslow, Dean L., Winthrop, Kevin L., Wong, Karen K., Wortmann, Glenn W., Wright, William F., Wyles, David L., Young, Jo-Anne H., Young, Vincent Bensan, Yun, Nadezhda, Zimmerli, Werner, Zinner, Stephen H., and Zurlo, John J.
- Published
- 2020
- Full Text
- View/download PDF
23. 64 - Epiglottitis
- Author
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Nayak, Jennifer L. and Weinberg, Geoffrey A.
- Published
- 2015
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- View/download PDF
24. Selective pre-priming of HA-specific CD4 T cells restores immunological reactivity to HA on heterosubtypic influenza infection
- Author
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Alam, Shabnam, primary, Chan, Cory, additional, Qiu, Xing, additional, Shannon, Ian, additional, White, Chantelle L., additional, Sant, Andrea J., additional, and Nayak, Jennifer L., additional
- Published
- 2017
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- View/download PDF
25. Immunization with Pneumocystis Cross-Reactive Antigen 1 (Pca1) Protects Mice against Pneumocystis Pneumonia and Generates Antibody to Pneumocystis jirovecii
- Author
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Tesini, Brenda L., primary, Wright, Terry W., additional, Malone, Jane E., additional, Haidaris, Constantine G., additional, Harber, Martha, additional, Sant, Andrea J., additional, Nayak, Jennifer L., additional, and Gigliotti, Francis, additional
- Published
- 2017
- Full Text
- View/download PDF
26. The Role of CD4 T Cell Memory in Generating Protective Immunity to Novel and Potentially Pandemic Strains of Influenza
- Author
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DiPiazza, Anthony, primary, Richards, Katherine A., additional, Knowlden, Zackery A. G., additional, Nayak, Jennifer L., additional, and Sant, Andrea J., additional
- Published
- 2016
- Full Text
- View/download PDF
27. Heterosubtypic influenza infection antagonizes elicitation of immunological reactivity to HA
- Author
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Nayak, Jennifer L., Alam, Shabnam, and Sant, Andrea J.
- Subjects
CD4-Positive T-Lymphocytes ,Mice, Inbred C57BL ,B-Lymphocytes ,Mice ,Influenza A Virus, H1N1 Subtype ,Orthomyxoviridae Infections ,Antibody Specificity ,Influenza A Virus, H3N2 Subtype ,Animals ,Epitopes, T-Lymphocyte ,Hemagglutinin Glycoproteins, Influenza Virus ,Antibodies, Viral ,Article - Abstract
Influenza-specific immunity in humans is unique because there are repeated exposures to viral strains containing genetically conserved epitopes recruiting memory CD4 T cells and novel epitopes stimulating naïve CD4 T cells, possibly resulting in competition between memory and naïve lymphocytes. In the studies described here, we evaluated the effect of this competition on CD4 T cell and B cell response specificity using a murine model of sequential influenza infection. We found striking and selective decreases in CD4 T cell reactivity to nonconserved HA epitopes following secondary influenza infection. Surprisingly, this shift in CD4 T cell specificity was associated with dramatic decreases in HA-specific antibody. These results suggest that repeated exposure to influenza viruses and vaccines containing conserved internal proteins may have unintended and negative consequences on the ability to induce HA-specific antibody to novel pandemic strains of influenza. These finding could have important implications on pandemic influenza preparedness strategies.
- Published
- 2013
28. Loss in CD4 T-cell responses to multiple epitopes in influenza due to expression of one additional MHC class II molecule in the host
- Author
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Nayak, Jennifer L and Sant, Andrea J
- Subjects
CD4-Positive T-Lymphocytes ,Immunodominant Epitopes ,Histocompatibility Antigens Class II ,Antigen-Presenting Cells ,Epitopes, T-Lymphocyte ,Original Articles ,Mice, Inbred C57BL ,Interferon-gamma ,Mice ,Influenza A Virus, H1N1 Subtype ,Orthomyxoviridae Infections ,Influenza Vaccines ,Influenza, Human ,Animals ,Humans - Abstract
An understanding of factors controlling CD4 T-cell immunodominance is needed to pursue CD4 T-cell epitope-driven vaccine design, yet our understanding of this in humans is limited by the complexity of potential MHC class II molecule expression. In the studies described here, we took advantage of genetically restricted, well-defined mouse strains to better understand the effect of increasing MHC class II molecule diversity on the CD4 T-cell repertoire and the resulting anti-influenza immunodominance hierarchy. Interferon-γ ELISPOT assays were implemented to directly quantify CD4 T-cell responses to I-A(b) and I-A(s) restricted peptide epitopes following primary influenza virus infection in parental and F(1) hybrid strains. We found striking and asymmetric declines in the magnitude of many peptide-specific responses in F(1) animals. These declines could not be accounted for by the lower surface density of MHC class II on the cell or by antigen-presenting cells failing to stimulate T cells with lower avidity T-cell receptors. Given the large diversity of MHC class II expressed in humans, these findings have important implications for the rational design of peptide-based vaccines that are based on the premise that CD4 T-cell epitope specificity can be predicted by a simple cataloguing of an individual's MHC class II genotype.
- Published
- 2012
29. Effect of Influenza A(H5N1) Vaccine Prepandemic Priming on CD4+ T-Cell Responses
- Author
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Nayak, Jennifer L., primary, Richards, Katherine A., additional, Yang, Hongmei, additional, Treanor, John J., additional, and Sant, Andrea J., additional
- Published
- 2014
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30. Contributors
- Author
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Abrahamian, Fredrick M., Allos, Ban Mishu, Apicella, Michael A., Ard, Kevin L., Arias, Cesar A., Augenbraun, Michael H., Averhoff, Francisco, Azar, Dimitri T., Baddour, Larry M., Baker, Carol J., Ballard, Ronald C., Barnes, Scott D., Barouch, Dan H., Barrett, Alan D., Barshak, Miriam Baron, Basavaraju, Sridhar V., Batteiger, Byron E., Baum, Stephen G., Bayer, Arnold S., Beckham, J. David, Beekmann, Susan E., Bell, Beth P., Bennett, John E., Bente, Dennis A., Berbari, Elie F., Bhimraj, Adarsh, Bisno, Alan L., Blackburn, Brian G., Blanton, Lucas S., Blaser, Martin J., Bleck, Thomas P., Bobak, David A., Bonnez, William, Boothroyd, John C., Bosque, Patrick J., Bower, John, Bradsher, Robert W., Jr., Brown, Kevin E., Brown, Patricia D., Brown-Elliott, Barbara A., Bruhn, Roberta L., Bryant, Amy E., Burd, Eileen M., Burns, Jane C., Bush, Larry M., Cano, Luz Elena, Carpenter, Charles C.J., Caserta, Mary T., Castagnola, Elio, Chaisson, Richard E., Chen, Sharon C-A., Chow, Anthony W., Cohen, Jeffrey I., Cohen, Myron S., Corey, Lawrence, Cover, Timothy L., Crossley, Kent B., Crumpacker, Clyde S., II, Currie, Bart J., D'Agata, Erika, Damon, Inger K., Darouiche, Rabih O., DeBiasi, Roberta L., Deepe, George S., Jr., Delemos, Andrew S., DeMuri, Gregory P., Dewar, Robin, Diaz, James H., Dienstag, Jules L., Dolin, Raphael, Donnenberg, Michael S., Donowitz, Gerald R., Dormitzer, Philip R., Drake, James M., Dumler, J. Stephen, DuPont, Herbert L., Durack, David T., Durand, Marlene L., Edelstein, Paul H., Edwards, Morven S., Ellison, Richard T., III, Endy, Timothy P., Engleberg, N. Cary, Erdem, Hakan, Ernst, Joel D., Fairhurst, Rick M., Fairley, Jessica K., Falsey, Ann R., Fekete, Thomas, Fey, Paul D., Fine, Steven M., Fitzgerald, Daniel W., Flores, Anthony R., Forster, Derek, Fowler, Vance G., Jr., Freedman, David O., Friedlander, Arthur M., Galgiani, John N., Gallo, Robert C., Gandhi, Tejal N., Garrett, Wendy S., Gaydos, Charlotte A., Geisbert, Thomas W., Gelfand, Jeffrey A., Gerding, Dale N., Gershon, Anne A., Gilsdorf, Janet R., Goldstein, Ellie J.C., Gordin, Fred M., Graman, Paul S., Griffin, Patricia M., Guerrant, Richard L., Gul, H. Cem, Haake, David A., Haas, David W., Haines, Charles, Hall, Caroline Breese, Hallak, Joelle, Halperin, Scott A., Hammerschlag, Margaret R., Haque, Rashidul, Harris, Jason B., Hawkins, Claudia, Hay, Roderick J., Henderson, David K., Hill, David R., Hirsch, Martin S., Hodowanec, Aimee, Holzman, Robert S., Hook, Edward W., III, Hooton, Thomas M., Horowitz, Harold W., Horsburgh, C. Robert, Jr., Horton, James M., Hospenthal, Duane R., Iovine, Nicole M., Iredell, Jonathan R., Ison, Michael G., Janda, J. Michael, Janoff, Edward N., Johannsen, Eric C., Kaye, Donald, Kaye, Kenneth M., Kazura, James W., Keystone, Jay S., Khudyakov, Yury, Kim, Rose, King, Charles H., Kirchhoff, Louis V., Klein, Jerome O., Klompas, Michael, Knoll, Bettina M., Knowlton, Kirk U., Koehler, Jane E., Kohlhoff, Stephan A., Kontoyiannis, Dimitrios P., Koralnik, Igor J., Koshy, Anita A., Kovacs, Joseph A., Kozarsky, Phyllis, Krieger, John, Kuehnert, Matthew J., Kumar, Nalin M., Levett, Paul N., Levine, Donald P., Levison, Matthew E., Lewis, Russell E., Lima, Aldo A.M., Limaye, Ajit P., Lipkin, W. Ian, Litman, Nathan, Lorber, Bennett, MacGregor, Rob Roy, Mackowiak, Philip A., Madoff, Lawrence C., Magill, Alan J., Maguire, James H., Maldarelli, Frank, Markoff, Lewis, Marrazzo, Jeanne M., Marrie, Thomas J., Marth, Thomas, Martin, David H., Martin, Gregory J., Marty, Francisco M., Masur, Henry, McBride, John T., McCormack, William M., McGowan, Catherine C., McIntosh, Kenneth, Mead, Paul S., Mikulska, Malgorzata, Miller, Robert F., Miller, Samuel I., Mitchell, David H., Modlin, John F., Mody, Rajal K., Montoya, José G., Moreillon, Philippe, Morris, J. Glenn, Jr., Munford, Robert S., Murphy, Edward L., Murphy, Timothy F., Murray, Barbara E., Murray, Clinton K., Musher, Daniel M., Narezkina, Anna, Nash, Theodore E., Nayak, Jennifer L., Neill, Marguerite A., Ohl, Christopher A., Okhuysen, Pablo C., Onderdonk, Andrew B., Osmon, Douglas R., Oxman, Michael N., Paessler, Slobodan, Palraj, Raj, Pappas, Peter G., Pasternack, Mark S., Patterson, Thomas F., Pavan-Langston, Deborah, Pegues, David A., Penn, Robert L., Perfect, John R., Perlman, Stanley, Petersen, Brett W., Peterson, Phillip K., Petri, William A., Jr., Petti, Cathy A., Phillips, Michael, Que, Yok-Ai, Radolf, Justin D., Raoult, Didier, Ray, Stuart C., Reboli, Annette C., Reitz, Marvin S., Jr., Renault, Cybèle A., Restrepo, Angela, Rex, John H., Rhee, Elizabeth G., Romero, José R., Rothman, Alan L., Roy, Craig R., Rupp, Mark E., Rupprecht, Charles E., Russo, Thomas A., Rutala, William A., Ryan, Edward T., Safdar, Amar, Salazar, Juan C., Savoia, Maria C., Sax, Paul E., Scheld, W. Michael, Schiffer, Joshua T., Schlossberg, David, Schneider, Thomas, Schwebke, Jane R., Segal, Leopoldo N., Sendi, Parham, Sepkowitz, Kent A., Septimus, Edward J., Seregin, Alexey, Shulman, Stanford T., Siberry, George K., Siddiqi, Omar K., Sifri, Costi D., Simberkoff, Michael S., Simonetti, Francesco R., Singh, Kamaljit, Singh, Nina, Singh, Upinder, Sinner, Scott W., Slater, Leonard N., Smulian, A. George, Sobel, Jack D., Sohail, M. Rizwan, Soper, David E., Sorrell, Tania C., Steckelberg, James M., Steere, Allen C., Steinberg, James P., Stephens, David S., Sterling, Timothy R., Stevens, Dennis L., Stratton, Charles W., IV, Suffredini, Anthony F., Suh, Kathryn N., Sulkowski, Mark S., Swartz, Morton N., Talbot, Thomas R., Tan, C. Sabrina, Tan, Ming, Thio, Chloe Lynne, Thomas, David L., Thomas, Stephen J., Thorner, Anna R., Tobón, Angela María, Tramont, Edmund C., Treanor, John J., Tsibris, Athe M.N., Tunkel, Allan R., Turner, Ronald B., Tyler, Kenneth L., Uluer, Ahmet, van de Beek, Diederik, Vannier, Edouard G., Van Schooneveld, Trevor C., Viscoli, Claudio, Wald, Ellen R., Waldor, Matthew K., Walker, David H., Wallace, Richard J., Jr., Walsh, Edward E., Walsh, Stephen R., Walzer, Peter D., Wanke, Christine A., Warren, Cirle A., Washburn, Ronald G., Waters, Valerie, Weber, David J., Weiden, Michael D., Weinberg, Geoffrey A., Weisdorf, Daniel J., Weiss, Louis M., Welch, David F., Wellems, Thomas E., White, A. Clinton, Jr., Whitley, Richard J., Wilson, Walter R., Wright, William F., Young, Jo-Anne H., Young, Vincent B., Yun, Nadezhda, Zimmerli, Werner, and Zurlo, John J.
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- 2017
- Full Text
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31. 9 - Epiglottitis
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Nayak, Jennifer L. and Weinberg, Geoffrey A.
- Published
- 2017
- Full Text
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32. Colaboradores
- Author
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Aagaard, Kjersti, Abrahamian, Fredrick M., Allos, Ban Mishu, Andes, David R., Aoki, Fred Y., Apicella, Michael A., Ard, Kevin L., Arias, Cesar A., Aronoff, David M., Augenbraun, Michael H., Averhoff, Francisco, Azar, Dimitri T., Baddour, Larry M., Baden, Lindsey R., Baker, Carol J., Ballard, Ronald C., Barber, Gerard R., Barnes, Scott D., Barouch, Dan H., Barrett, Alan D., Barshak, Miriam Baron, Basavaraju, Sridhar V., Batteiger, Byron E., Baum, Stephen G., Bayer, Arnold S., Beckham, J. David, Beekmann, Susan E., Bell, Beth P., Bennett, John E., Bente, Dennis A., Berbari, Elie F., Berman, Jonathan, Bertino, Joseph S., Jr., Bhimraj, Adarsh, Birdsall, Holly H., Bisno, Alan L., Blackburn, Brian G., Blanton, Lucas S., Blaser, Martin J., Bleck, Thomas P., Blijlevens, Nicole M.A., Bobak, David A., Bonnez, William, Boothroyd, John C., Borio, Luciana L., Bosque, Patrick J., Bower, John, Bradsher, Robert W., Jr., Brook, Itzhak, Brown, Kevin E., Brown, Patricia D., Brown-Elliott, Barbara A., Bruhn, Roberta L., Bryant, Amy E., Burd, Eileen M., Burns, Jane C., Bush, Larry M., Calderwood, Stephen B., Cano, Luz Elena, Carpenter, Charles C.J., Caserta, Mary T., Castagnola, Elio, Chaisson, Richard E., Chambers, Henry F., Chapman, Stephen J., Chappell, James D., Chen, Lea Ann, Chen, Sharon C-A., Chow, Anthony W., Clark, Rebecca A., Cohen, Jeffrey I., Cohen, Myron S., Cohen-Poradosu, Ronit, Cohn, Susan E., Connors, Mark, Corey, Lawrence, Cottrell, Mackenzie L., Cover, Timothy L., Cox, Heather L., Craig, William A., Crossley, Kent B., Crumpacker, Clyde S., II, Curran, James W., Currie, Bart J., D’Agata, Erika, Damon, Inger K., Darouiche, Rabih O., DeBiasi, Roberta L., Deepe, George S., Jr., del Rio, Carlos, Delemos, Andrew S., DeLeo, Frank R., DeMuri, Gregory P., Densen, Peter, Dermody, Terence S., Dewar, Robin, Diaz, James H., Dieffenbach, Carl W., Dienstag, Jules L., Doi, Yohei, Dolin, Raphael, Donnelly, J. Peter, Donnenberg, Michael S., Donowitz, Gerald R., Dormitzer, Philip R., Drake, James M., Dumler, J. Stephen, Dummer, J. Stephen, DuPont, Herbert L., Durack, David T., Durand, Marlene L., Edelstein, Paul H., Edmond, Michael B., Edwards, John E., Jr., Edwards, Morven S., Eliopoulos, George M., Ellison, Richard T., III, Endy, Timothy P., Engleberg, N. Cary, Erdem, Hakan, Ernst, Joel D., Ernst, Peter B., Fairhurst, Rick M., Fairley, Jessica K., Falkow, Stanley, Falsey, Ann R., Fauci, Anthony S., Fekete, Thomas, Fey, Paul D., Fine, Steven M., Fitzgerald, Daniel W., Flores, Anthony R., Forster, Derek, Fowler, Vance G., Jr., Freedman, David O., Friedlander, Arthur M., Galgiani, John N., Gallin, John I., Gallo, Robert C., Gandhi, Tejal N., Garrett, Wendy S., Gaydos, Charlotte A., Geisbert, Thomas W., Gelfand, Jeffrey A., Gelone, Steven P., Gerding, Dale N., Gershon, Anne A., Gilsdorf, Janet R., Goldstein, Ellie J.C., Gordin, Fred M., Graman, Paul S., Grayson, M. Lindsay, Greene, Jeffrey Bruce, Griffin, Patricia M., Griffith, David E., Guerrant, Richard L., Gul, H. Cem, Haake, David A., Haas, David W., Haines, Charles, Hall, Caroline Breese, Hallak, Joelle, Halperin, Scott A., Hammerschlag, Margaret R., Haque, Rashidul, Harris, Jason B., Hawkins, Claudia, Hay, Roderick J., Hedberg, Craig W., Henderson, David K., Henderson, Donald A., High, Kevin P., Hill, Adrian V.S., Hill, David R., Hinman, Alan R., Hirsch, Martin S., Hodowanec, Aimee, Hohl, Tobias M., Holland, Steven M., Holzman, Robert S., Hook, Edward W., III, Hooper, David C., Hooton, Thomas M., Horowitz, Harold W., Horsburgh, C. Robert, Jr., Horton, James M., Hospenthal, Duane R., Hsueh, Kevin, Hughes, James M., Hynes, Noreen A., Iovine, Nicole M., Iredell, Jonathan R., Ison, Michael G., Janda, J. Michael, Janoff, Edward N., Johannsen, Eric C., Kashuba, Angela D.M., Kasper, Dennis L., Kaye, Donald, Kaye, Keith S., Kaye, Kenneth M., Kazura, James W., Keystone, Jay S., Khabbaz, Rima, Khan, David A., Khudyakov, Yury, Kim, Rose, King, Charles H., Kirchhoff, Louis V., Klein, Jerome O., Klompas, Michael, Knoll, Bettina M., Knowlton, Kirk U., Koehler, Jane E., Kohlhoff, Stephan A., Könönen, Eija, Kontoyiannis, Dimitrios P., Koralnik, Igor J., Korpe, Poonum S., Koshy, Anita A., Kovacs, Joseph A., Kozarsky, Phyllis, Krieger, John, Kroger, Andrew T., Kuehnert, Matthew J., Kumar, Nalin M., Kuruvilla, Merin Elizabeth, LaRocque, Regina C., Leggett, James E., Legido-Quigley, Helena, Levett, Paul N., Levine, Donald P., Levison, Matthew E., Levitt, Alexandra, Lewis, Russell E., Liles, W. Conrad, Lima, Aldo A.M., Limaye, Ajit P., Lipkin, W. Ian, Litman, Nathan, Lorber, Bennett, Luna, Ruth Ann, MacDougall, Conan, MacGregor, Rob Roy, Mackowiak, Philip A., Madoff, Lawrence C., Magill, Alan J., Maguire, James H., Maldarelli, Frank, Markoff, Lewis, Marrazzo, Jeanne M., Marrie, Thomas J., Marth, Thomas, Martin, David H., Martin, Gregory J., Marty, Francisco M., Maslow, Melanie Jane, Masur, Henry, Mawle, Alison, Mayer, Kenneth H., McBride, John T., McCarthy, James S., McCormack, William M., McGowan, Catherine C., McIntosh, Kenneth, Mead, Paul S., Mikulska, Malgorzata, Miller, Robert F., Miller, Samuel I., Mitchell, David H., Modlin, John F., Mody, Rajal K., Moellering, Robert C., Jr., Moffa, Matthew, Moir, Susan, Montoya, José G., Moore, Thomas A., Moreillon, Philippe, Morris, J. Glenn, Jr., Morse, Caryn Gee, Moseley, Robin, Munford, Robert S., Murphy, Edward L., Murphy, Timothy F., Murray, Barbara E., Murray, Clinton K., Murray, Patrick R., Musher, Daniel M., Nagel, Jerod L., Nannini, Esteban C., Narezkina, Anna, Nash, Theodore E., Nauseef, William M., Nayak, Jennifer L., Neill, Marguerite A., O’Donnell, Judith A., Ohl, Christopher A., Okhuysen, Pablo C., Onderdonk, Andrew B., Opal, Steven M., Orenstein, Walter A., Osmon, Douglas R., Osterholm, Michael T., Ostroff, Stephen M., Oxman, Michael N., Paessler, Slobodan, Page, Andrea V., Pai, Manjunath P., Palmore, Tara N., Palraj, Raj, Pappas, Peter G., Pasternack, Mark S., Patterson, Thomas F., Pavan-Langston, Deborah, Pegues, David A., Penn, Robert L., Perfect, John R., Perlman, Stanley, Petersen, Brett W., Peterson, Phillip K., Petri, William A., Jr., Petti, Cathy A., Philips, Jennifer A., Philley, Julie V., Phillips, Michael, Pickering, Larry K., Piot, Peter, Pogue, Jason M., Pop-Vicas, Aurora, Portal-Celhay, Cynthia, Powers, John H., III, Price, Richard N., Que, Yok-Ai, Radolf, Justin D., Ram, Sanjay, Raoult, Didier, Ravdin, Jonathan I., Ray, Stuart C., Reboli, Annette C., Reitz, Marvin S., Jr., Relman, David A., Renault, Cybèle A., Restrepo, Angela, Rex, John H., Rhee, Elizabeth G., Roberts, Norbert J., Jr., Romero, José R., Rothman, Alan L., Roy, Craig R., Ruoff, Kathryn L., Rupp, Mark E., Rupprecht, Charles E., Russo, Thomas A., Rutala, William A., Ryan, Edward T., Safdar, Amar, Sajadi, Mohammad M., Salazar, Juan C., Sarria, Juan Carlos, Savoia, Maria C., Sax, Paul E., Scheld, W. Michael, Schiffer, Joshua T., Schlossberg, David, Schneider, Thomas, Schuchat, Anne, Schwebke, Jane R., Sears, Cynthia L., Segal, Leopoldo N., Sendi, Parham, Sepkowitz, Kent A., Septimus, Edward J., Seregin, Alexey, Shulman, Stanford T., Siberry, George K., Siddiqi, Omar K., Sifri, Costi D., Simberkoff, Michael S., Simonetti, Francesco R., Singh, Kamaljit, Singh, Nina, Singh, Upinder, Sinner, Scott W., Sivapalasingam, Sumathi, Slater, Leonard N., Smulian, A. George, Sobel, Jack D., Sohail, M. Rizwan, Soper, David E., Sorrell, Tania C., Steckelberg, James M., Steere, Allen C., Steigbigel, Neal H., Steinberg, James P., Stephens, David S., Sterling, Timothy R., Stevens, David A., Stevens, Dennis L., Strahilevitz, Jacob, Stratton, Charles W., IV, Suffredini, Anthony F., Suh, Kathryn N., Sulkowski, Mark S., Swartz, Morton N., Talbot, Thomas R., Tan, C. Sabrina, Tan, Ming, Thio, Chloe Lynne, Thomas, David L., Thomas, Lora D., Thomas, Stephen J., Thorner, Anna R., Tobón, Angela María, Tramont, Edmund C., Treanor, John J., Trubiano, Jason, Tsibris, Athe M.N., Tunkel, Allan R., Turner, Ronald B., Tyler, Kenneth L., Uluer, Ahmet, van de Beek, Diederik, van der Velden, Walter J.F. M., Vannier, Edouard G., Van Schooneveld, Trevor C., Versalovic, James, Viscoli, Claudio, Wald, Ellen R., Waldor, Matthew K., Walker, David H., Wallace, Richard J., Jr., Walsh, Edward E., Walsh, Stephen R., Walzer, Peter D., Wanke, Christine A., Warren, Cirle A., Washburn, Ronald G., Waters, Valerie, Weber, David J., Weiden, Michael D., Weinberg, Geoffrey A., Weisdorf, Daniel J., Weiss, Louis M., Welch, David F., Wellems, Thomas E., Wenzel, Richard P., Wharton, Melinda, White, A. Clinton, Jr., Whitley, Richard J., Wilson, Walter R., Wortmann, Glenn W., Wright, William F., Young, Jo-Anne H., Young, Vincent B., Yun, Nadezhda, Zimmerli, Werner, Zinner, Stephen H., and Zurlo, John J.
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- 2016
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33. 64 - Epiglotitis
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Nayak, Jennifer L. and Weinberg, Geoffrey A.
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- 2016
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34. Cutting Edge: Heterosubtypic Influenza Infection Antagonizes Elicitation of Immunological Reactivity to Hemagglutinin
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Nayak, Jennifer L., primary, Alam, Shabnam, additional, and Sant, Andrea J., additional
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- 2013
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35. CD4+ T-Cell Expansion Predicts Neutralizing Antibody Responses to Monovalent, Inactivated 2009 Pandemic Influenza A(H1N1) Virus Subtype H1N1 Vaccine
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Nayak, Jennifer L., primary, Fitzgerald, Theresa F., additional, Richards, Katherine A., additional, Yang, Hongmei, additional, Treanor, John J., additional, and Sant, Andrea J., additional
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- 2012
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36. The Utility and Limitations of Current Web-Available Algorithms To Predict Peptides Recognized by CD4 T Cells in Response to Pathogen Infection
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Chaves, Francisco A., primary, Lee, Alvin H., additional, Nayak, Jennifer L., additional, Richards, Katherine A., additional, and Sant, Andrea J., additional
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- 2012
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37. T Cell Immunology for the Clinician
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Nayak, Jennifer L., primary and Sant, Andrea J., additional
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- 2011
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38. Analyses of the Specificity of CD4 T Cells During the Primary Immune Response to Influenza Virus Reveals Dramatic MHC-Linked Asymmetries in Reactivity to Individual Viral Proteins
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Nayak, Jennifer L., primary, Richards, Katherine A., additional, Chaves, Francisco A., additional, and Sant, Andrea J., additional
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- 2010
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39. Antiviral Treatment and Prophylaxis of Influenza Virus in Children
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Nayak, Jennifer L., primary and Treanor, John J., additional
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- 2009
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40. Effect of Influenza A(H5N1) Vaccine Prepandemic Priming on CD4+ T-Cell Responses.
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Nayak, Jennifer L., Richards, Katherine A., Hongmei Yang, Treanor, John J., and Sant, Andrea J.
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H5N1 Influenza , *T cells , *ENZYME-linked immunosorbent assay , *IMMUNIZATION , *IMMUNOGLOBULINS , *DRUG efficacy , *VACCINATION , *PHYSIOLOGY - Abstract
Introduction. Previous priming with avian influenza vaccines results in more rapid and more robust neutralizing antibody responses upon revaccination, but the role CD4+ T cells play in this process is not currently known. Methods. Human subjects previously enrolled in trials of inactivated influenza A(H5N1) vaccines and naive subjects were immunized with an inactivated subunit influenza A/Indonesia/5/05(H5N1) vaccine. Neutralizing antibody responses were measured by a microneutralization assay, and hemagglutinin (HA)-specific and nucleoprotein (NP)-specific CD4+ T-cell responses were quantified using interferon γ enzyme-linked immunosorbent spot assays. Results. While vaccination induced barely detectable CD4+ T-cell responses specific for HA in the previously unprimed group, primed subjects had readily detectable HA-specific memory CD4+ T cells at baseline and mounted a more robust response to HA-specific epitopes after vaccination. There were no differences between groups when conserved NP-specific CD4+ T-cell responses were examined. Interestingly, neutralizing antibody responses following revaccination were significantly higher in individuals who mounted a CD4+ T-cell response to the H5 HA protein, a correlation not observed for NP-specific responses. Conclusions. These findings suggest that prepandemic vaccination results in an enriched population of HA-specific CD4+ T cells that are recruited on rechallenge with a drifted vaccine variant and contribute to more robust and more rapid neutralizing antibody responses. [ABSTRACT FROM AUTHOR]
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- 2015
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41. Immunization with PneumocystisCross-Reactive Antigen 1 (Pca1) Protects Mice against PneumocystisPneumonia and Generates Antibody to Pneumocystis jirovecii
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Tesini, Brenda L., Wright, Terry W., Malone, Jane E., Haidaris, Constantine G., Harber, Martha, Sant, Andrea J., Nayak, Jennifer L., and Gigliotti, Francis
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- 2017
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42. Meningitis in a School-Aged Child due to Haemophilus influenzae Type E during the Post-Conjugate Vaccine Era-Monroe County, NY, 2011.
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Kennedy BS, Weimer AC, Bedard B, Nayak JL, Sacheli D, Ricci J, Meyer DD, and Hubbard D
- Abstract
In late October 2011, the Monroe County Department of Public Health (MCDPH) was notified of a suspected case of meningitis in a 9-year old girl from Monroe County, NY. Laboratory testing at the New York State Department of Health (NYSDOH) Wadsworth Center confirmed the identification of Haemophilus influenzae serotype e (Hie) isolated from the patient's cerebrospinal fluid (CSF) using real-time polymerase chain reaction (RT-PCR). The universal immunization of infants with conjugate H. influenzae type b (Hib) vaccine has significantly reduced the incidence of invasive Hib disease, including meningitis, one of the most serious complications for infected children. Not surprisingly, as the epidemiology of invasive H. influenzae continues to change, non-Hib serotypes will likely become more common. The findings reported here underscore the importance for clinicians, public health officials, and laboratory staff to consider non-Hib pathogens in pediatric cases of meningitis, especially when initial investigations are inconclusive.
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- 2014
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