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Your search keyword '"Nawata, Masashi"' showing total 38 results
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38 results on '"Nawata, Masashi"'

6. Short- to Mid-Term Clinical Outcomes of Posterior-Stabilized Cementless Total Knee Arthroplasty with Trabecular Metal Components

Author

Momose,Takashige, Nakamura,Yukio, Nakano,Masaki, Maeda,Takashi, Morioka,Susumu, Sobajima,Atsushi, Nakatsuchi,Yukio, Takahashi,Jun, Nawata,Masashi, Momose,Takashige, Nakamura,Yukio, Nakano,Masaki, Maeda,Takashi, Morioka,Susumu, Sobajima,Atsushi, Nakatsuchi,Yukio, Takahashi,Jun, and Nawata,Masashi

Abstract

Takashige Momose,1 Yukio Nakamura,2 Masaki Nakano,2 Takashi Maeda,1 Susumu Morioka,3 Atsushi Sobajima,1 Yukio Nakatsuchi,1 Jun Takahashi,2 Masashi Nawata1 1Department of Orthopaedic Surgery, Marunouchi Hospital, Matsumoto, Nagano, 390-8601, Japan; 2Department of Orthopaedic Surgery, Shinshu University School of Medicine, Matsumoto, Nagano, 390-8621, Japan; 3Department of Orthopaedic Surgery, Chikuma Central Hospital, Chikuma, Nagano, 387– 8512, JapanCorrespondence: Yukio NakamuraDepartment of Orthopaedic Surgery, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, JapanTel +81-263-37-2659Fax +81-263-35-8844Email yxn14@aol.jpObjective: This study aimed to evaluate the short- to mid-term clinical results of posterior-stabilized trabecular metal total knee arthroplasty (TKA) with cementless fixation of all components and investigate the radiographic changes of tibial and patellar components and cut bone surfaces over time.Methods: We retrospectively collected the data of 128 knees from 88 consecutive patients who had undergone initial TKA with NexGen LPS-Flex TM implants. A total of 66 knees from 45 patients (mean ± standard deviation age: 70.3 ± 7.5 years) met the selection criteria, which had been employed cementless fixation of all parts and at least 3 years of postoperative follow-up duration. Clinical evaluations included range of motion, conventional knee score, function score, postoperative complications, and revision. For radiological evaluations, the bone contact surface of each implant was divided into 7 zones for tibial component and 2 zones for patellar component. Each region was examined immediately after surgery, at 6 and 12 months, and then every year afterwards.Results: The mean observation period of 45 subjects was 4.2 years. Adequate fixation of tibial components was maintained during follow-up, although the patellar components of 2 knees required revision after repeated falls. No loosening was observed in any implants

Published
2021

22. Safety of autologous bone marrow-derived mesenchymal stem cell transplantation for cartilage repair in 41 patients with 45 joints followed for up to 11 years and 5 months

Author

Wakitani, Shigeyuki, primary, Okabe, Takahiro, additional, Horibe, Shuji, additional, Mitsuoka, Tomoki, additional, Saito, Masanobu, additional, Koyama, Tsuyoshi, additional, Nawata, Masashi, additional, Tensho, Keiji, additional, Kato, Hiroyuki, additional, Uematsu, Kota, additional, Kuroda, Ryosuke, additional, Kurosaka, Masahiro, additional, Yoshiya, Shinichi, additional, Hattori, Koji, additional, and Ohgushi, Hajime, additional

Published
2011
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38. Nonfrozen preservation of articular cartilage by epigallocatechin-3-gallate reversibly regulating cell cycle and NF-kappaB expression.

Author

Bae JY, Han DW, Matsumura K, Wakitani S, Nawata M, and Hyon SH

Subjects
Aged, Aged, 80 and over, Animals, Biomechanical Phenomena drug effects, Catechin pharmacology, Cell Survival drug effects, Chondrocytes cytology, Chondrocytes drug effects, Chondrocytes metabolism, Collagen metabolism, Cyclins metabolism, Extracellular Matrix metabolism, Female, Freezing, Glycosaminoglycans metabolism, Humans, Male, Middle Aged, Rabbits, Cartilage, Articular cytology, Catechin analogs & derivatives, Cell Cycle drug effects, NF-kappa B metabolism, Tissue Preservation methods
Abstract

Epigallocatechin-3-O-gallate (EGCG) is known to have beneficial effects on the nonfrozen preservation of mammalian cells and tissues. In this study, we aimed at testifying the hypothesis that the deleterious effects of cold preservation of articular cartilages can be ameliorated by the addition of EGCG to the storage media. Articular cartilages were preserved in a storage solution composed of serum-free RPMI 1640 media with 1 mM EGCG at 4 degrees C for 1-4 weeks. The regulatory effects of EGCG on cell cycle progression as well as expression levels of CyCliNS (CCNs) and nuclear factor-kappaB (NF-kappaB) were investigated in articular chondrocytes. Chondrocyte viability of cartilages preserved with EGCG was significantly well maintained for 2 weeks with high contents of glycosaminoglycan and total collagen. These beneficial effects of EGCG were confirmed by histological and immunohistochemical observations showing well-preserved cartilaginous structures and delayed denaturation of extracellular matrices. The compressive elastic modulus of cartilages preserved with EGCG was close to that of fresh specimens. Increased cell population at the G(0)/G(1) phase by EGCG returned to the normal level after EGCG removal, whereas decrease at the G(2)/M phase did not. Negatively regulated expression of CCND1, CCNE2, or NF-kappaB in EGCG-treated cells was restored by removing EGCG, but not CCNA2 and CCNB1. After 8 weeks of in vivo implantation into full-thickness cartilage defects in rabbits, the cartilages preserved with EGCG were found to be integrated with the host environment and support tissue regeneration. It is suggested that EGCG plays effective roles in preserving and repairing articular cartilages by reversibly regulating cell cycle at G(0)/G(1) phase and NF-kappaB expression.

Published
2010
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