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The article is aimed at determining theoretical views on processes of financial and environmental management of the agricultural sector. It analyzes the financial and environmental management of the agricultural sector of the economy, including the assessment of components of air, water, forest and land resources, crop and livestock production. The authors substantiate the system of ensuring the balanced development of the agricultural sector and examine measures to motivate the organization of eco-friendly agricultural production. The analysis of pollutant emissions into the atmosphere from stationary sources of pollution in Ukraine for 2017-2021 showed that the largest sources of pollution into the atmosphere in Ukraine for 2017-2021 were sulfur dioxide (25.7% in 2021), carbon monoxide into the atmosphere in Ukraine for 2017-2021 (31.4% in 2021) and methane (20.3% in 2021). The article defines the ways of state support for the agricultural sector of the economy and outlines the main principles of the agricultural sector development strategy. The revealed positive impact of the agricultural sector on the environment is ensured by two factors: financial and environmental responsibility manifested through management decision-making measures and financial and environmental motivation manifested through material, social and environmental values of the agricultural producer, consumer and society as a whole.

The study is dedicated to the role of resource-saving as an efficient tool for environmental and production management in the context of ensuring sustainable development and economic security of enterprises. The article analyzes the environment and assesses the progress of environmental protection in the national economy according to the Environmental Performance Index. It is determined that resource saving is aimed at optimizing the use of resources and minimizing losses in production processes to reduce enterprises' environmental impact and increase their competitiveness. Industrially developed countries spend on average 2.5% of GDP annually on innovative energy and resource-saving solutions (the UK – 2.2%, Germany and France – 2.5%, the USA – 2.7%, Japan – 2.9%, Sweden – 3.3%), while the investment resource-saving potential in Ukraine, unfortunately, is minimized and amounts to 0.34%. At the same time, the share of enterprises' funds in the total expenditures on innovations is constantly increasing to 83.9% in 2020. More than 80% of enterprises implemented resource-efficient measures precisely because of changes in energy and raw material prices, independently finding ways to implement their actions to efficiently use resources.

Mid-regional pro-adrenomedullin (MR-proADM) is useful for risk stratification in patients with sepsis and respiratory infections. The study's purpose was to assess the available data and determine the association between MR-proADM levels and mortality in COVID-19 participants. A comprehensive literature search of medical electronic databases was performed including PubMed, Web of Science, Scopus, Cochrane, and grey literature for relevant data published from 1 January 2020, to 20 November 2022. Mean differences (MD) with 95% confidence intervals (CI) were calculated. Fourteen studies reported MR-proADM levels in survivors vs. non-survivors of COVID-19 patients. Pooled analysis showed that MR-proADM level in the survivor group was 0.841 ± 0.295 nmol/L for patients who survive COVID-19, compared to 1.692 ± 0.761 nmol/L for non-survivors (MD = −0.78; 95%CI: −0.92 to −0.64; p < 0.001). The main finding of this study is that mortality of COVID-19 is linked to MR-proADM levels, according to this meta-analysis. The use of MR-proADM might be extremely beneficial in triaging, assessing probable therapy escalation, predicting potential complications during therapy or significant clinical deterioration of patients, and avoiding admission which may not be necessary. Nevertheless, in order to confirm the obtained data, it is necessary to conduct large prospective studies that will address the potential diagnostic role of MR-proADM as a marker of COVID-19 severity. Severity of COVID-19 seems to be linked to MR-proADM levels and can be used as a potential marker for predicting a patient's clinical course. The use of MR-proADM might be beneficial in triaging, assessing probable therapy escalation, predicting potential complications during therapy or significant clinical deterioration of patients, and avoiding admission which may not be necessary. For patients with COVID-19, MR-proADM may be an excellent prognostic indicator because it is a marker of endothelial function that may predict the precise impact on the equilibrium between vascular relaxation and contraction and lowers platelet aggregation inhibitors, coagulation inhibitors, and fibrinolysis activators in favor of clotting factors. [ABSTRACT FROM AUTHOR]

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Background: The purpose of our study was to determine the efficacy of intubation with VieScope® and Macintosh laryngoscope in different scenarios of simulated COVID-19 patients by paramedics wearing personal protective equipment (PPE) for aerosol gener-ating procedures (AGPs)., Methods: Study was designed as a prospective, observational, randomized, crossover simulation trial. 37 paramedics took part in the study. They performed endotracheal intubation (ETI) of a person suspected of COVID-19. Intubation was performed using VieS-cope® and Macintosh laryngoscopes in two research scenarios: Scenario A - normal airway and Scenario B - difficult airway. Both the order of participants and the methods of intubation were random., Results: In Scenario A, time to intubation using VieScope® and Macintosh laryngoscope amounted to 35.3 (IQR; 32-40) seconds and 35.8 (IQR: 30-40)s, respectively. Nearly all participants performed ETI successfully both with VieScope® and Macintosh laryngo-scope (100% vs. 94.6%). In scenario B, intubation with the VieScope®, compared to the Macintosh laryngoscope, was associated with a shorter intubation time (p<0.001), a higher success rate of the first intubation attempt (p<0.001), a better visualization degree glottis (p=0.012) and ease of intubation (p<0.001)., Conclusion: Our analysis suggests that the use of a VieScope® compared to Macintosh laryngoscope in difficult airway intuba-tion performed by paramedics wearing PPE-AGP is associated with shorter intubation times, greater intubation efficiency as well as better visualization of the glottis. Additional clinical trials are necessary to confirm the obtained results.