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12. Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

Author

Aragonés, Julián, primary, Schneider, Martin, additional, Van Geyte, Katie, additional, Fraisl, Peter, additional, Dresselaers, Tom, additional, Mazzone, Massimiliano, additional, Dirkx, Ruud, additional, Zacchigna, Serena, additional, Lemieux, Hélène, additional, Jeoung, Nam Ho, additional, Lambrechts, Diether, additional, Bishop, Tammie, additional, Lafuste, Peggy, additional, Diez-Juan, Antonio, additional, Harten, Sarah K, additional, Van Noten, Pieter, additional, De Bock, Katrien, additional, Willam, Carsten, additional, Tjwa, Marc, additional, Grosfeld, Alexandra, additional, Navet, Rachel, additional, Moons, Lieve, additional, Vandendriessche, Thierry, additional, Deroose, Christophe, additional, Wijeyekoon, Bhathiya, additional, Nuyts, Johan, additional, Jordan, Benedicte, additional, Silasi-Mansat, Robert, additional, Lupu, Florea, additional, Dewerchin, Mieke, additional, Pugh, Chris, additional, Salmon, Phil, additional, Mortelmans, Luc, additional, Gallez, Bernard, additional, Gorus, Frans, additional, Buyse, Johan, additional, Sluse, Francis, additional, Harris, Robert A, additional, Gnaiger, Erich, additional, Hespel, Peter, additional, Van Hecke, Paul, additional, Schuit, Frans, additional, Van Veldhoven, Paul, additional, Ratcliffe, Peter, additional, Baes, Myriam, additional, Maxwell, Patrick, additional, and Carmeliet, Peter, additional

Published
2008
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13. Muscle energetics in exercising horses

Author

Votion, Dominique-Marie, primary, Navet, Rachel, additional, Lacombe, Véronique Anne, additional, Sluse, Francis, additional, Essén-Gustavsson, Birgitta, additional, Hinchcliff, Kenneth William, additional, Rivero, José-Luis L., additional, Serteyn, Didier, additional, and Valberg, Stephanie, additional

Published
2007
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14. History and Clinical Features of Atypical Myopathy in Horses in Belgium (2000-2005)

Author

Votion, Dominique-M., primary, Linden, Annick, additional, Saegerman, Claude, additional, Engels, Patrick, additional, Erpicum, Michel, additional, Thiry, Etienne, additional, Delguste, Catherine, additional, Rouxhet, Serge, additional, Demoulin, Vincent, additional, Navet, Rachel, additional, Sluse, Francis, additional, Serteyn, Didier, additional, Galen, Gaby, additional, and Amory, Hélène, additional

Published
2007
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17. Reduced cardiac output is associated with decreased mitochondrial efficiency in the non-ischemic ventricular wall of the acute myocardial-infarcted dog

Author

Almsherqi, Zakaria A, primary, McLachlan, Craig S, additional, Slocinska, Malgorzata B, additional, Sluse, Francis E, additional, Navet, Rachel, additional, Kocherginsky, Nikolai, additional, Kostetski, Iouri, additional, Shi, Dong-Yun, additional, Liu, Shan-Lin, additional, Mossop, Peter, additional, and Deng, Yuru, additional

Published
2006
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25. Uncoupling protein and alternative oxidase of Dictyostelium discoideum: occurrence, properties and protein expression during vegetative life and starvation-induced early development

Author

Jarmuszkiewicz, Wieslawa, Behrendt, Maciej, Navet, Rachel, and Sluse, Francis E.

Subjects
MITOCHONDRIA, DICTYOSTELIUM discoideum, OXIDASES
Abstract

In this study we show that mitochondria of Dictyostelium discoideum contain both alternative oxidase (AOX) and uncoupling protein (UCP). AOX was stimulated by purine mononucleoside and was monomeric. UCP was stimulated by free fatty acids and was poorly sensitive to GTP. Both proteins collaborated in energy dissipation when activated together. AOX expression in free-living ameboid cells decreased strongly from exponential to stationary phase of growth but much less during starvation-induced aggregation. In contrast, UCP expression was constant in all conditions indicating permanent need. Our results suggest that AOX could play a role in cell differentiation, mainly by protecting prespore cells from programmed cell death. [Copyright &y& Elsevier]

Published
2002
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26. Muscle energetics in exercising horses

Author

Votion, Dominique-Marie, Navet, Rachel, Lacombe, Véronique Anne, Sluse, Francis, Essén-Gustavsson, Birgitta, Hinchcliff, Kenneth William, Rivero, José-Luis L., Serteyn, Didier, and Valberg, Stephanie

Published
2007
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27. Saccharomyces cerevisiae Mitoproteome Plasticity in Response to Recombinant Alternative Ubiquinol Oxidase

Author

Mathy, Grégory, Navet, Rachel, Gerkens, Pascal, Leprince, Pierre, De Pauw, Edwin, M. Sluse-Goffart, Claudine, E. Sluse, Francis, and Douette, Pierre

Abstract

The energy-dissipating alternative oxidase (AOX) from Hansenula anomala was expressed in Saccharomyces cerevisiae. The recombinant AOX was functional. A comparative analysis by two-dimensional differential in-gel electrophoresis (2D-DIGE) of mitochondrial protein patterns found in wild-type and recombinant AOX strains was performed. 60 proteins exhibiting a significant difference in their abundance were identified. Interestingly, proteins implicated in major metabolic pathways such as Krebs cycle and amino acid biosynthesis were up-regulated. Surprisingly, an up-regulation of the respiratory-chain complex III was associated with a down-regulation of the ATP synthase complex. Keywords: alternative oxidase • yeast • mitoproteome • proteomics • two-dimensional differential in-gel electrophoresis

Published
2006
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28. Mitochondrial Respiratory Chain Complex Patterns from Acanthamoeba castellaniiand Lycopersicon esculentum: Comparative Analysis by BN-PAGE and Evidence of Protein–Protein Interaction Between Alternative Oxidase and Complex III

Author

Navet, Rachel, Jarmuszkiewicz, Wieslawa, Douette, Pierre, Sluse-Goffart, Claudine, and Sluse, Francis

Abstract

We have previously shown that a kinetic interplay exists between the cytochrome pathway and the alternative oxidase in mitochondria from amoeba Acanthamoeba castellanii. Native interaction analyses using blue native gel electrophoresis coupled to denaturating electrophoresis and immunodetection have indicated associations between alternative oxidase and oxidative phosphorylation complexes in both amoeba and tomato mitochondria. These associations are dependent on the expression level of alternative oxidase according to the physiological state in both organisms. Alternative oxidase associates broadly with large complexes of the respiratory chain when it is expressed in large amount, i.e., in ripe tomato and exponentially growing amoeba. On the contrary, alternative oxidase interacts specifically with complex III even if expression of the oxidase is low, i.e., in green tomato and stationary phase amoeba. This specific interaction represents a higher level of regulation driven by protein–protein interactions leading to a direct kinetic interplay between the cytochrome pathway and alternative oxidase in both plant and amoeba mitochondria.

Published
2004
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29. Deficiency or inhibition of oxygen sensor Phd1 induces hypoxia tolerance by reprogramming basal metabolism

Author

Robert Silasi-Mansat, Pieter Van Noten, Christopher W. Pugh, Florea Lupu, Peter Carmeliet, Julián Aragonés, Peter J. Ratcliffe, Hélène Lemieux, Diether Lambrechts, Tom Dresselaers, A. Grosfeld, Patrick H. Maxwell, Nam Ho Jeoung, Martin Schneider, Lieve Moons, Robert A. Harris, Francis Sluse, Sarah K. Harten, Peter Fraisl, Bernard Gallez, Katie Van Geyte, Phil Salmon, Johan Buyse, Rachel Navet, Massimiliano Mazzone, Paul Van Hecke, Katrien De Bock, Luc Mortelmans, Myriam Baes, Bénédicte F. Jordan, Peter Hespel, Thierry VandenDriessche, Bhathiya Wijeyekoon, Christophe Deroose, Frans Schuit, Mieke Dewerchin, Frans Gorus, Carsten Willam, Marc Tjwa, Peggy Lafuste, Erich Gnaiger, Serena Zacchigna, Paul P. Van Veldhoven, Tammie Bishop, Ruud Dirkx, Johan Nuyts, Antonio Diez-Juan, Aragonés, Julián, Schneider, Martin, Van Geyte, Katie, Fraisl, Peter, Dresselaers, Tom, Mazzone, Massimiliano, Dirkx, Ruud, Zacchigna, Serena, Lemieux, Hélène, Jeoung, Nam Ho, Lambrechts, Diether, Bishop, Tammie, Lafuste, Peggy, Diez Juan, Antonio, Harten, Sarah K., Van Noten, Pieter, De Bock, Katrien, Willam, Carsten, Tjwa, Marc, Grosfeld, Alexandra, Navet, Rachel, Moons, Lieve, Vandendriessche, Thierry, Deroose, Christophe, Wijeyekoon, Bhathiya, Nuyts, Johan, Jordan, Benedicte, Silasi Mansat, Robert, Lupu, Florea, Dewerchin, Mieke, Pugh, Chri, Salmon, Phil, Mortelmans, Luc, Gallez, Bernard, Gorus, Fran, Buyse, Johan, Sluse, Franci, Harris, Robert A., Gnaiger, Erich, Hespel, Peter, Van Hecke, Paul, Schuit, Fran, Van Veldhoven, Paul, Ratcliffe, Peter, Baes, Myriam, Maxwell, Patrick, Carmeliet, Peter, and The Center for Transgene Technology and Gene Therapy, Katholieke Universiteit (K.U.) Leuven, Leuven, B-3000, Belgium

Subjects
Genetics (clinical), Genetics, Mitochondrion, medicine.disease_cause, Mice, 0302 clinical medicine, Glutamates, Models, Carbon Radioisotopes, Hypoxia, Tomography, ComputingMilieux_MISCELLANEOUS, 0303 health sciences, Carbon Isotopes, Homozygote, Skeletal, Immunohistochemistry, Mitochondria, X-Ray Computed, medicine.anatomical_structure, Embryo, 030220 oncology & carcinogenesis, Muscle, Procollagen-proline dioxygenase, medicine.symptom, Oxidation-Reduction, medicine.medical_specialty, Nuclear Magnetic Resonance, Ischemia, Procollagen-Proline Dioxygenase, Oxidative phosphorylation, Carbohydrate metabolism, Biology, Models, Biological, 03 medical and health sciences, Oxygen Consumption, Internal medicine, medicine, Animals, Muscle, Skeletal, Nuclear Magnetic Resonance, Biomolecular, 030304 developmental biology, Mammalian, Skeletal muscle, Hypoxia (medical), Carbon Dioxide, Fibroblasts, Embryo, Mammalian, medicine.disease, Biological, Energy Metabolism, Glucose, Tomography, X-Ray Computed, Basal Metabolism, Endocrinology, Oxidative stress, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology, Biomolecular
Abstract

HIF prolyl hydroxylases (PHD1-3) are oxygen sensors that regulate the stability of the hypoxia-inducible factors (HIFs) in an oxygen-dependent manner. Here, we show that loss of Phd1 lowers oxygen consumption in skeletal muscle by reprogramming glucose metabolism from oxidative to more anaerobic ATP production through activation of a Pparalpha pathway. This metabolic adaptation to oxygen conservation impairs oxidative muscle performance in healthy conditions, but it provides acute protection of myofibers against lethal ischemia. Hypoxia tolerance is not due to HIF-dependent angiogenesis, erythropoiesis or vasodilation, but rather to reduced generation of oxidative stress, which allows Phd1-deficient myofibers to preserve mitochondrial respiration. Hypoxia tolerance relies primarily on Hif-2alpha and was not observed in heterozygous Phd2-deficient or homozygous Phd3-deficient mice. Of medical importance, conditional knockdown of Phd1 also rapidly induces hypoxia tolerance. These findings delineate a new role of Phd1 in hypoxia tolerance and offer new treatment perspectives for disorders characterized by oxidative stress. ispartof: Nature Genetics vol:40 issue:2 pages:170-180 ispartof: location:United States status: published

Published
2008

30. Mitoproteome plasticity of rat brown adipocytes in response to cold acclimation.

Author

Navet R, Mathy G, Douette P, Dobson RL, Leprince P, De Pauw E, Sluse-Goffart C, and Sluse FE

Subjects
ATP Synthetase Complexes biosynthesis, Acclimatization, Animals, Body Temperature Regulation, Cold Temperature, Electrophoresis, Gel, Two-Dimensional methods, Ion Channels biosynthesis, Male, Mitochondrial Proteins biosynthesis, Rats, Rats, Wistar, Uncoupling Protein 1, Adipocytes metabolism, Adipose Tissue, Brown cytology, Mitochondria metabolism, Proteomics methods
Abstract

Cold acclimation induces an adaptative increase in respiration in brown adipose tissue (BAT). A comparative analysis by two-dimensional differential in-gel electrophoresis of mitochondrial protein patterns found in rat control and cold-acclimated BAT was performed. A total of 58 proteins exhibiting significant differences in their abundance was unambiguously identified. Proteins implicated in the major catabolic pathways were up-regulated as were ATP synthase and mitofilin. Moreover, these results support the fact that adipocytes can balance their ATP synthesis and their heat production linked to UCP1-sustained uncoupling.

Published
2007
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