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3. Enhancing Ocular Surface in Dry Eye Disease Patients: A Clinical Evaluation of a Topical Formulation Containing Sesquiterpene Lactone Helenalin

Author

Ng, Dalia, primary, Altamirano-Vallejo, Juan Carlos, additional, Navarro-Partida, Jose, additional, Sanchez-Aguilar, Oscar Eduardo, additional, Inzunza, Andres, additional, Valdez-Garcia, Jorge Eugenio, additional, Gonzalez-de-la-Rosa, Alejandro, additional, Bustamante-Arias, Andres, additional, Armendariz-Borunda, Juan, additional, and Santos, Arturo, additional

Published
2024
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7. Nutraceuticals: A Promising Therapeutic Approach in Ophthalmology

Author

Castro-Castaneda, Carlos Rodrigo, primary, Altamirano-Lamarque, Francisco, additional, Ortega-Macías, Alan Gabriel, additional, Santa Cruz-Pavlovich, Francisco J., additional, Gonzalez-De la Rosa, Alejandro, additional, Armendariz-Borunda, Juan, additional, Santos, Arturo, additional, and Navarro-Partida, Jose, additional

Published
2022
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9. An Oral Polyphenol Formulation to Modulate the Ocular Surface Inflammatory Process and to Improve the Symptomatology Associated with Dry Eye Disease

Author

Ng, Dalia, primary, Altamirano-Vallejo, Juan Carlos, additional, Gonzalez-De la Rosa, Alejandro, additional, Navarro-Partida, Jose, additional, Valdez-Garcia, Jorge Eugenio, additional, Acosta-Gonzalez, Ricardo, additional, Martinez Camarillo, Juan Carlos, additional, Bustamante-Arias, Andres, additional, Armendariz-Borunda, Juan, additional, and Santos, Arturo, additional

Published
2022
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10. Topical Pirfenidone-Loaded Liposomes Ophthalmic Formulation Reduces Haze Development after Corneal Alkali Burn in Mice

Author

Diaz-Palomera, Carlos Daniel, primary, Vidal-Paredes, Isaac Alejandro, additional, Navarro-Partida, Jose, additional, Cid-Hernandez, Margarita, additional, Rosales-Rivera, Luis Carlos, additional, De la Rosa-Bibiano, Ricardo, additional, Monroy-Ramirez, Hugo Christian, additional, Santos, Arturo, additional, and Armendariz-Borunda, Juan, additional

Published
2022
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11. Oxidative and Fibrinolytic Mechanisms: Two Important Processes to Consider in Platelet Storage.

Author

Garcia-Bañuelos, Jesus Javier, Galicia-Moreno, Marina, Monroy-Ramirez, Hugo Christian, Navarro-Partida, Jose, Bastidas-Ramirez, Blanca Estela, Santos, Arturo, and Armendariz-Borunda, Juan

Subjects
FIBRINOLYTIC agents, BLOOD platelets, BLOOD collection
Abstract

Copyright of Turkish Journal of Hematology is the property of Galenos Yayinevi Tic. LTD. STI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2023
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12. Topical Triamcinolone Acetonide-Loaded Liposome Formulation Used as an Adjuvant to Intravitreal Ranibizumab Therapy for Neovascular Age-Related Macular Degeneration

Author

Navarro-Partida, Jose, primary, Altamirano-Vallejo, Juan Carlos, additional, Aceves Franco, Luis Abraham, additional, Gonzalez-Cortes, Jesús, additional, Hernandez-Da Mota, Sergio, additional, García-Aguirre, Jose Gerardo, additional, Azuara-Galindo, Carlos David, additional, Castro-Castaneda, Carlos Rodrigo, additional, Armendariz-Borunda, Juan, additional, and Santos, Arturo, additional

Published
2021
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13. Response to comment on: Feasibility and safety of vitrectomy under topical anesthesia in an office-based setting

Author

Trujillo-Sanchez, Gloria, Rosa, Alejandro, Navarro-Partida, Jose, Haro-Morlett, Luis, Altamirano-Vallejo, Juan, and Santos, Arturo

Subjects
Health
Abstract

Byline: Gloria. Trujillo-Sanchez, Alejandro. Rosa, Jose. Navarro-Partida, Luis. Haro-Morlett, Juan. Altamirano-Vallejo, Arturo. SantosSir,We appreciate the authors for their keen interest in our article.[1] We cautiously analyzed their observations and concerns [...]

Published
2019

17. Feasibility and safety of vitrectomy under topical anesthesia in an office-based setting

Author

Trujillo-Sanchez, Gloria, La Rosa, Alejandro Gonzalez-De, Navarro-Partida, Jose, Haro-Morlett, Luis, Altamirano-Vallejo, Juan, and Santos, Arturo

Subjects
Treatment outcome -- Analysis, Anesthesia -- Usage -- Research, Vitrectomy -- Usage -- Safety and security measures -- Research, Health
Abstract

Byline: Gloria. Trujillo-Sanchez, Alejandro. Gonzalez-De La Rosa, Jose. Navarro-Partida, Luis. Haro-Morlett, Juan. Altamirano-Vallejo, Arturo. Santos Purpose: The purpose of this study was to evaluate the feasibility and safety of office-based [...]

Published
2018

19. Topical Triamcinolone Acetonide-Loaded Liposomes as Primary Therapy for Macular Edema Secondary to Branch Retinal Vein Occlusion: A Pilot Study

Author

Navarro-Partida, Jose, primary, Altamirano-Vallejo, Juan Carlos, additional, Lopez-Naranjo, Edgar Jose, additional, Gonzalez-De la Rosa, Alejandro, additional, Manzano-Ramírez, Alejandro, additional, Apatiga-Castro, Luis Miguel, additional, Armendáriz-Borunda, Juan, additional, and Santos, Arturo, additional

Published
2020
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20. Pirfenidone Is an Agonistic Ligand for PPARα and Improves NASH by Activation of SIRT1/LKB1/pAMPK

Author

Sandoval‐Rodriguez, Ana, primary, Monroy‐Ramirez, Hugo Christian, additional, Meza‐Rios, Alejandra, additional, Garcia‐Bañuelos, Jesus, additional, Vera‐Cruz, Jose, additional, Gutiérrez‐Cuevas, Jorge, additional, Silva‐Gomez, Jorge, additional, Staels, Bart, additional, Dominguez‐Rosales, Jose, additional, Galicia‐Moreno, Marina, additional, Vazquez‐Del Mercado, Monica, additional, Navarro‐Partida, Jose, additional, Santos‐Garcia, Arturo, additional, and Armendariz‐Borunda, Juan, additional

Published
2020
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21. Novel Triamcinolone Acetonide-Loaded Liposomal Topical Formulation Improves Contrast Sensitivity Outcome After Femtosecond Laser-Assisted Cataract Surgery

Author

Gonzalez-De la Rosa, Alejandro, primary, Navarro-Partida, Jose, additional, Altamirano-Vallejo, Juan Carlos, additional, Jauregui-Garcia, Gerardo Daniel, additional, Acosta-Gonzalez, Ricardo, additional, Ibanez-Hernandez, Miguel Angel, additional, Mora-Gonzalez, Guadalupe Fernando, additional, Armendáriz-Borunda, Juan, additional, and Santos, Arturo, additional

Published
2019
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24. Characterization and Pharmacokinetics of Triamcinolone Acetonide-Loaded Liposomes Topical Formulations for Vitreoretinal Drug Delivery

Author

Altamirano-Vallejo, Juan C., primary, Navarro-Partida, Jose, additional, Gonzalez-De la Rosa, Alejandro, additional, Hsiao, Jane H., additional, Olguín-Gutierrez, Jose S., additional, Gonzalez-Villegas, Ana C., additional, Keller, Brian C., additional, Bouzo-Lopez, Lourdes, additional, and Santos, Arturo, additional

Published
2018
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28. Surgical Results in Ocriplasmin Candidates With Symptomatic Vitreomacular Traction Syndrome.

Author

Vasquez, Dario H., Altamirano, Juan C., Casaus, Angel, Del Valle, Rodrigo A., Gonzalez, Roberto, Gonzalez-De La Rosa, Alejandro, Navarro-Partida, Jose, Vasquez, Martin A., and Santos, Arturo

Subjects
VISUAL acuity, VITRECTOMY, DIABETIC retinopathy, OPTICAL coherence tomography, MEDICAL records
Abstract

Purpose: To report surgical outcomes in a series of cases with symptomatic vitreomacular traction that met MIVI-TRUST (Microplasmin for intravitreous injection-traction release without surgical treatment) criteria for ocriplasmin use who underwent primary 25-gauge vitrectomy. Materials and Methods: A single-center retrospective chart review study was performed in patients who underwent primary 25-gauge vitrectomy for symptomatic vitreomacular traction (VTM) from January 2013 through January 2016. Pre- and postoperative visual acuity (measured by the early treatment diabetic retinopathy acuity test), and posterior hyaloid focal attachment to the macula (demonstrated by high-definition optical coherence tomography) were analyzed. In addition, intra- and postoperative complications were obtained from medical records. Results: Fifteen consecutive cases of symptomatic VMT traction that underwent primary 25-gauge vitrectomy were included. All met the MIVI-TRUST criteria for ocriplasmin use. In all cases, VMT resolution, macular hole closure, and improvement in best corrected visual acuity (BCVA) were observed. Mean visual acuity improved from 56.53 ± 16.04 letters at baseline to 73.13 ± 7.46 letters at 24 weeks of follow-up. The mean BCVA improvement from baseline was 16.60 letters (range 6--44), which was statistically significant (P < 0.0001). Ten of fifteen patients (66.6%) showed significant improvement of their BCVA to 20/40 or better (70 or more in ETDRS visual acuity test). No significant intra- or postoperative complications were documented. Conclusions: Primary 25-gauge pars plana vitrectomy in eyes with symptomatic vitreomacular traction is able to efficiently resolve VMT and macular holes, improving vision in candidates for intravitreal injection of ocriplasmin. This well-tolerated surgical procedure may be a reliable and predictable alternative for resolving VMT pathology. [ABSTRACT FROM AUTHOR]

Published
2018
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30. Association of single-nucleotide polymorphisms in non-coding regions of the TLR4 gene with primary open angle glaucoma in a Mexican population.

Author

Navarro-Partida, Jose, Alvarado Castillo, Beatriz, Martinez-Rizo, Abril Bernardette, Rosales-Diaz, Ramses, Velazquez-Fernandez, Jesus Bernardino, and Santos, Arturo

Subjects
*SINGLE nucleotide polymorphisms, *OPEN-angle glaucoma, *TOLL-like receptors, *NON-coding RNA, *MEXICANS, *EXONUCLEASES, *DISEASES
Abstract

Background: Toll-like receptor 4 (TLR4) non-coding polymorphisms are associated to primary open angle glaucoma (POAG), normal tension glaucoma, and pseudoexfoliation glaucoma. This study was performed to determine whether non-coding single nucleotide polymorphisms (SNPs) in theTLR4gene contribute to POAG in a Mexican population. Material and methods: A total of 187 unrelated Mexican patients with POAG and 109 control subjects were included. Allelic, genotypic, and haplotypic diversity was assessed for the non-coding polymorphisms rs11536889, rs1927911, rs12377632, and rs2149356 of theTLR4gene. Genotyping of target SNPs was performed by 5′ exonuclease allelic discrimination assays. Results: Strong linkage disequilibrium was observed among the SNPs (D’> 0.818), which were located in one haplotype block. The rs11536889 polymorphism was not associated to POAG in any case. The frequency of the minor allele of rs2149356 was significantly higher in the glaucoma group, conferring an increased risk of POAG (p= 0.0018, OR = 1.803, 95% CI 1.2556–2.5890) whereas minor allele of rs12377632 was significantly lower, attributing a protective effect (p= 0.0001, OR = 0.6662, 95% CI 0.4753–0.9339). Subjects with genotypes carrying the minor allele of rs1927911 and rs2149356 shown an increased risk for POAG (p= 0.03, OR = 1.78, 95% CI 1.10–2.87, andp< 0.0004, OR =2.62, 95%CI 1.61–4.27 respectively). Finally, we found significant risk haplotypes. The GTT haplotype (constituted by rs1927911, rs12377632, and rs2149356) reached the higher OR (p= 0.0026, OR = 4.70, 95% CI 1.73–12.77). Conclusions: We have identified intronicTLR4SNPs as genetic susceptibility alleles for POAG in a Mexican population. Our findings support the association of theTLR4gene with POAG. [ABSTRACT FROM AUTHOR]

Published
2017
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32. Adenoviral delivery of dominant-negative transforming growth factor β type II receptor up-regulates transcriptional repressor SKI-like oncogene, decreases matrix metalloproteinase 2 in hepatic stellate cell and prevents liver fibrosis in rats

Author

Marquez-Aguirre, Ana, primary, Sandoval-Rodriguez, Ana, additional, Gonzalez-Cuevas, Jaime, additional, Bueno- Topete, Miriam, additional, Navarro-Partida, Jose, additional, Arellano-Olivera, Immaculada, additional, Lucano-Landeros, Silvia, additional, and Armendariz-Borunda, Juan, additional

Published
2009
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34. Breaking down the Barrier : Topical Liposomes as Nanocarriers for Drug Delivery into the Posterior Segment of the Eyeball

Author

Santos, Arturo, Hsiao, Jane, Altamirano-Vallejo, Juan Carlos, Navarro-Partida, Jose, and Gonzalez-De La Rosa, Alejandro

Subjects
Medical / Nursing / Pharmacology
Abstract

Topical instillation is the most widely preferred noninvasive route of drug administration to treat diseases affecting the anterior segment of the eye. Nonetheless, the ocular bioavailability for deeper ocular tissues is very low. Different routes of administration, such as intravitreal injections, periocular injections, and systemic administration, have been used to deliver drugs into the posterior segment ocular tissues. However, the presence of blood-retinal barriers (BRBs) makes systemic administration an impractical approach, whereas the drug delivery with the periocular administration route is compromised by ocular static and dynamic barriers. On the other hand, intravitreal injection, the most common and widely recommended route for drug administration to treat posterior ocular diseases, is related to several side effects such as endophthalmitis, hemorrhage, retinal detachment, and poor patient tolerance. Diverse strategies to overcome ocular barriers have been explored for topical drop formulations in order to deliver drugs into the posterior segment ocular tissues. In this chapter, we will review the promising topical nanocarriers for drug delivery into the posterior segment of the eye, emphasizing the use of liposomes for topical ophthalmic formulations targeting the vitreous cavity and the retina.

Published
2020

35. Adenoviral delivery of dominant-negative transforming growth factor beta type II receptor up-regulates transcriptional repressor SKI-like oncogene, decreases matrix metalloproteinase 2 in hepatic stellate cell and prevents liver fibrosis in rats.

Author

Marquez-Aguirre A, Sandoval-Rodriguez A, Gonzalez-Cuevas J, Bueno-Topete M, Navarro-Partida J, Arellano-Olivera I, Lucano-Landeros S, and Armendariz-Borunda J

Subjects
Adenoviridae metabolism, Animals, Body Weight, Cells, Cultured, Hepatic Stellate Cells cytology, Intracellular Signaling Peptides and Proteins metabolism, Liver Cirrhosis chemically induced, Liver Cirrhosis pathology, Matrix Metalloproteinase 2 genetics, Matrix Metalloproteinase 3 genetics, Matrix Metalloproteinase 3 metabolism, Oncogene Proteins metabolism, Protein Serine-Threonine Kinases metabolism, Proto-Oncogene Proteins metabolism, Rats, Receptor, Transforming Growth Factor-beta Type II, Receptors, Transforming Growth Factor beta metabolism, Repressor Proteins metabolism, Signal Transduction physiology, Thioacetamide pharmacology, Transduction, Genetic, Transgenes, Up-Regulation, Adenoviridae genetics, Gene Transfer Techniques, Hepatic Stellate Cells metabolism, Intracellular Signaling Peptides and Proteins genetics, Liver Cirrhosis prevention & control, Matrix Metalloproteinase 2 metabolism, Oncogene Proteins genetics, Protein Serine-Threonine Kinases genetics, Proto-Oncogene Proteins genetics, Receptors, Transforming Growth Factor beta genetics, Repressor Proteins genetics
Abstract

Background: Dominant-negative transforming growth factor beta type II receptor (TbetaRIIDeltacyt) is a protein that blocks transforming growth factor (TGF-beta) signaling. Because the consequences of blocking TGF-beta have not been completely elucidated in liver fibrosis, we analysed the effects of adenoviral delivery of TbetaRIIDeltacyt on profibrogenic genes and matrix metalloproteinase (MMP) proteins, as well as on TGF-beta signal repressor SKI-like oncogene (SnoN), in cultured hepatic stellate cells (HSCs) and in a rat model of liver fibrosis., Methods: To induce liver fibrosis, rats were treated with thioacetamide for 7 weeks and administrated once with Ad-TbetaRIIDeltacyt or Ad-betagal through the iliac vein. Fibrosis was measured by morphometric analysis. We evaluated SnoN by western blot, immunocytochemistry and immunohistochemistry; MMP activity was determined by zymography and profibrogenic gene expression by the real-time reverse transcriptase-polymerase chain reaction in cultured HSCs and liver tissue., Results: Profibrogenic gene expression of collagen alpha1 (I), TGF-beta1, platelet-derived growth factor-B, plasminogen activator inhibitor (PAI)-1, tissue inhibitor of matrix metalloproteinase-1 and MMP-2 was down-regulated; whereas MMP-3 was over-expressed in response to Ad-TbetaRIIDeltacyt in HSCs. Moreover, zymography assays corroborated MMP-2 and MMP-3 changes in activity. Surprisingly, anti-TGF-beta molecular intervention increased nuclear SnoN in HSCs. In vivo, Ad-TbetaRIIDeltacyt reduced liver fibrosis, increased nuclear SnoN in sinusoidal cells, and also produced significant suppression in collagen alpha1 (I), TGF-beta1, PAI-1, MMP-2 and over-expression in MMP-3 in thioacetamide-intoxicated animals., Conclusions: The results obtained in the present study suggest that the molecular mechanism for the blocking effects of Ad-TbetaRIIDeltacyt in TGF-beta signaling acts via up-regulation of the transcriptional repressor SnoN, which antagonizes TGF-beta signaling (TGF-beta/Smad-pathway inhibitor). Consequently, profibrogenic genes are down-regulated.

Published
2009
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