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2. A critical appraisal of the four systematic reviews and meta-analysis on stereotactic body radiation therapy versus external beam radiotherapy for painful bone metastases and where we go from here

Author

Wong, Henry C. Y., primary, Chan, Adrian Wai, additional, Johnstone, Peter, additional, Simone II, Charles B., additional, Navarro-Domenech, Inmaculada, additional, Hoskin, Peter, additional, Johnstone, Candice, additional, Recht, Abram, additional, Menten, Johan, additional, van der Linden, Yvette M., additional, van der Velden, Joanne M., additional, Nguyen, Quynh-Nhu, additional, Lutz, Stephen, additional, Andratschke, Nicolaus, additional, Wilmann, Jonas, additional, Kazmierska, Joanna, additional, Spalek, Mateusz, additional, Lim, Fiona, additional, Yu, H. Michael, additional, Perez, Brad, additional, Marta, Gustavo Nader, additional, Vassiliou, Vassilios, additional, Lee, Shing Fung, additional, Bonomo, Pierluigi, additional, Rembielak, Agata, additional, Chow, Edward, additional, Oldenburger, Eva, additional, and Raman, Srinivas, additional

Published
2023
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4. Addressing concerns and uncertainties surrounding the application of palliative radiotherapy in cases with a 30-day expected mortality

Author

MS Radiotherapie, Navarro-Domenech, Inmaculada, Behroozian, Tara, Hoskin, Peter, Johnstone, Candice, Recht, Abram, Menten, Johan, Oldenburger, Eva, van der Linden, Yvette M, van der Velden, Joanne M, Nguyen, Quynh-Nhu, Simone, Charles B, Johnstone, Peter, Lutz, Stephen, Milton, Lauren, Andratschke, Nicolaus, Willmann, Jonas, Kazmierska, Joanna, Spałek, Mateusz, Marta, Gustavo N, Chow, Edward, Raman, Srinivas, MS Radiotherapie, Navarro-Domenech, Inmaculada, Behroozian, Tara, Hoskin, Peter, Johnstone, Candice, Recht, Abram, Menten, Johan, Oldenburger, Eva, van der Linden, Yvette M, van der Velden, Joanne M, Nguyen, Quynh-Nhu, Simone, Charles B, Johnstone, Peter, Lutz, Stephen, Milton, Lauren, Andratschke, Nicolaus, Willmann, Jonas, Kazmierska, Joanna, Spałek, Mateusz, Marta, Gustavo N, Chow, Edward, and Raman, Srinivas

Published
2023

5. A critical appraisal of the four systematic reviews and meta-analysis on stereotactic body radiation therapy versus external beam radiotherapy for painful bone metastases and where we go from here

Author

MS Radiotherapie, Wong, Henry C Y, Chan, Adrian Wai, Johnstone, Peter, Simone, Charles B, Navarro-Domenech, Inmaculada, Hoskin, Peter, Johnstone, Candice, Recht, Abram, Menten, Johan, van der Linden, Yvette M, van der Velden, Joanne M, Nguyen, Quynh-Nhu, Lutz, Stephen, Andratschke, Nicolaus, Wilmann, Jonas, Kazmierska, Joanna, Spalek, Mateusz, Lim, Fiona, Yu, H Michael, Perez, Brad, Marta, Gustavo Nader, Vassiliou, Vassilios, Lee, Shing Fung, Bonomo, Pierluigi, Rembielak, Agata, Chow, Edward, Oldenburger, Eva, Raman, Srinivas, MS Radiotherapie, Wong, Henry C Y, Chan, Adrian Wai, Johnstone, Peter, Simone, Charles B, Navarro-Domenech, Inmaculada, Hoskin, Peter, Johnstone, Candice, Recht, Abram, Menten, Johan, van der Linden, Yvette M, van der Velden, Joanne M, Nguyen, Quynh-Nhu, Lutz, Stephen, Andratschke, Nicolaus, Wilmann, Jonas, Kazmierska, Joanna, Spalek, Mateusz, Lim, Fiona, Yu, H Michael, Perez, Brad, Marta, Gustavo Nader, Vassiliou, Vassilios, Lee, Shing Fung, Bonomo, Pierluigi, Rembielak, Agata, Chow, Edward, Oldenburger, Eva, and Raman, Srinivas

Published
2023

6. Appropriateness of the 30-day expected mortality metric in palliative radiation treatment: a narrative review

Author

Arts-assistenten Radiotherapie, Navarro-Domenech, Inmaculada, Behroozian, Tara, Hoskin, Peter, Johnstone, Candice, Recht, Abram, Menten, Johan, Oldenburger, Eva, van der Linden, Yvette M., van der Velden, Joanne M., Nguyen, Quynh Nhu, Simone, Charles B., Johnstone, Peter, Lutz, Stephen, Milton, Lauren, Andratschke, Nicolaus, Willmann, Jonas, Kazmierska, Joanna, Spałek, Mateusz, Marta, Gustavo N., Chow, Edward, Raman, Srinivas, Arts-assistenten Radiotherapie, Navarro-Domenech, Inmaculada, Behroozian, Tara, Hoskin, Peter, Johnstone, Candice, Recht, Abram, Menten, Johan, Oldenburger, Eva, van der Linden, Yvette M., van der Velden, Joanne M., Nguyen, Quynh Nhu, Simone, Charles B., Johnstone, Peter, Lutz, Stephen, Milton, Lauren, Andratschke, Nicolaus, Willmann, Jonas, Kazmierska, Joanna, Spałek, Mateusz, Marta, Gustavo N., Chow, Edward, and Raman, Srinivas

Published
2023

7. Addressing concerns and uncertainties surrounding the application of palliative radiotherapy in cases with a 30-day expected mortality

Author

Navarro-Domenech, Inmaculada, Behroozian, Tara, Hoskin, Peter, Johnstone, Candice, Recht, Abram, Menten, Johan, Oldenburger, Eva, van der Linden, Yvette M, van der Velden, Joanne M, Nguyen, Quynh-Nhu, Simone, Charles B, Johnstone, Peter, Lutz, Stephen, Milton, Lauren, Andratschke, Nicolaus; https://orcid.org/0000-0003-3647-5916, Willmann, Jonas, Kazmierska, Joanna, Spałek, Mateusz, Marta, Gustavo N, Chow, Edward, Raman, Srinivas, Navarro-Domenech, Inmaculada, Behroozian, Tara, Hoskin, Peter, Johnstone, Candice, Recht, Abram, Menten, Johan, Oldenburger, Eva, van der Linden, Yvette M, van der Velden, Joanne M, Nguyen, Quynh-Nhu, Simone, Charles B, Johnstone, Peter, Lutz, Stephen, Milton, Lauren, Andratschke, Nicolaus; https://orcid.org/0000-0003-3647-5916, Willmann, Jonas, Kazmierska, Joanna, Spałek, Mateusz, Marta, Gustavo N, Chow, Edward, and Raman, Srinivas

Published
2023

8. Appropriateness of the 30-day expected mortality metric in palliative radiation treatment: a narrative review

Author

Navarro-Domenech, Inmaculada, Behroozian, Tara, Hoskin, Peter, Johnstone, Candice, Recht, Abram, Menten, Johan, Oldenburger, Eva, van der Linden, Yvette M, van der Velden, Joanne M, Nguyen, Quynh-Nhu, Simone, Charles B, Johnstone, Peter, Lutz, Stephen, Milton, Lauren, Andratschke, Nicolaus; https://orcid.org/0000-0003-3647-5916, Willmann, Jonas; https://orcid.org/0000-0002-2531-3551, Kazmierska, Joanna, Spałek, Mateusz, Marta, Gustavo N, Chow, Edward, Raman, Srinivas, Navarro-Domenech, Inmaculada, Behroozian, Tara, Hoskin, Peter, Johnstone, Candice, Recht, Abram, Menten, Johan, Oldenburger, Eva, van der Linden, Yvette M, van der Velden, Joanne M, Nguyen, Quynh-Nhu, Simone, Charles B, Johnstone, Peter, Lutz, Stephen, Milton, Lauren, Andratschke, Nicolaus; https://orcid.org/0000-0003-3647-5916, Willmann, Jonas; https://orcid.org/0000-0002-2531-3551, Kazmierska, Joanna, Spałek, Mateusz, Marta, Gustavo N, Chow, Edward, and Raman, Srinivas

Abstract

BACKGROUND AND OBJECTIVE The 30-day expected mortality rate is frequently used as a metric to determine which patients benefit from palliative radiation treatment (RT). We conducted a narrative review to examine whether its use as a metric might be appropriate for patient selection. METHODS A literature review was conducted to identify relevant studies that highlight the benefits of palliative RT in timely symptom management among patients with a poor performance status, the accuracy of predicting survival near the end of life and ways to speed up the process of RT administration through rapid response clinics. KEY CONTENT AND FINDINGS Several trials have demonstrated substantial response rates for pain and/or bleeding by four weeks and sometimes within the first two weeks after RT. Models of patient survival have limited accuracy, particularly for predicting whether patients will die within the next 30 days. Dedicated Rapid Access Palliative RT (RAPRT) clinics, in which patients are assessed, simulated and treated on the same day, reduce the number of patient visits to the radiation oncology department and hence the burden on the patient as well as costs. CONCLUSIONS Single-fraction palliative RT should be offered to eligible patients if they are able to attend treatment and could potentially benefit from symptom palliation, irrespective of predicted life expectancy. We discourage the routine use of the 30-day mortality as the only metric to decide whether to offer RT. More common implementation of RAPRT clinics could result in a significant benefit for patients of all life expectancies, but particularly those having short ones.

Published
2023

9. A critical appraisal of the four systematic reviews and meta- analysis on stereotactic body radiation therapy versus external beam radiotherapy for painful bone metastases and where we go from here

Author

Wong, Henry C Y, Chan, Adrian Wai, Johnstone, Peter, Simone, Charles B, Navarro-Domenech, Inmaculada, Hoskin, Peter, Johnstone, Candice, Recht, Abram, Menten, Johan, van der Linden, Yvette M, van der Velden, Joanne M, Nguyen, Quynh-Nhu, Lutz, Stephen, Andratschke, Nicolaus; https://orcid.org/0000-0003-3647-5916, Wilmann, Jonas, Kazmierska, Joanna, Spalek, Mateusz, Lim, Fiona, Yu, H Michael, Perez, Brad, Marta, Gustavo Nader, Vassiliou, Vassilios, Lee, Shing Fung, Bonomo, Pierluigi, Rembielak, Agata, Chow, Edward, Oldenburger, Eva, Raman, Srinivas, Wong, Henry C Y, Chan, Adrian Wai, Johnstone, Peter, Simone, Charles B, Navarro-Domenech, Inmaculada, Hoskin, Peter, Johnstone, Candice, Recht, Abram, Menten, Johan, van der Linden, Yvette M, van der Velden, Joanne M, Nguyen, Quynh-Nhu, Lutz, Stephen, Andratschke, Nicolaus; https://orcid.org/0000-0003-3647-5916, Wilmann, Jonas, Kazmierska, Joanna, Spalek, Mateusz, Lim, Fiona, Yu, H Michael, Perez, Brad, Marta, Gustavo Nader, Vassiliou, Vassilios, Lee, Shing Fung, Bonomo, Pierluigi, Rembielak, Agata, Chow, Edward, Oldenburger, Eva, and Raman, Srinivas

Abstract

Radiotherapy is an important treatment modality for pain control in patients with bone metastases. Stereotactic body radiation therapy (SBRT), which allows delivering a much higher dose per fraction while sparing critical structures compared to conventional external beam radiotherapy (cEBRT), has become more widely used, especially in the oligometastatic setting. Randomized controlled trials (RCTs) comparing the pain response rate of SBRT and cEBRT for bone metastases have shown conflicting results, as have four recent systematic reviews with meta-analyses of these trials. Possible reasons for the different outcomes between these reviews include differences in methodology, which trials were included, and the endpoints examined and how they were defined. We suggest ways to improve analysis of these RCTs, particularly performing an individual patient-level meta-analysis since the trials included heterogeneous populations. The results of such studies will help guide future investigations needed to validate patient selection criteria, optimize SBRT dose schedules, include additional endpoints (such as the time to onset of pain response, durability of pain response, quality of life (QOL), and side effects of SBRT), and better assess the cost-effectiveness and trade-offs of SBRT compared to cEBRT. An international Delphi consensus to guide selection of optimal candidates for SBRT is warranted before more prospective data is available.

Published
2023

11. Appropriateness of the 30-day expected mortality metric in palliative radiation treatment: a narrative review

Author

Navarro-Domenech, Inmaculada, primary, Behroozian, Tara, additional, Hoskin, Peter, additional, Johnstone, Candice, additional, Recht, Abram, additional, Menten, Johan, additional, Oldenburger, Eva, additional, van der Linden, Yvette M., additional, van der Velden, Joanne M., additional, Nguyen, Quynh-Nhu, additional, Simone II, Charles B., additional, Johnstone, Peter, additional, Lutz, Stephen, additional, Milton, Lauren, additional, Andratschke, Nicolaus, additional, Willmann, Jonas, additional, Kazmierska, Joanna, additional, Spałek, Mateusz, additional, Marta, Gustavo N., additional, Chow, Edward, additional, and Raman, Srinivas, additional

Published
2023
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12. Addressing concerns and uncertainties surrounding the application of palliative radiotherapy in cases with a 30-day expected mortality

Author

Navarro-Domenech, Inmaculada, primary, Behroozian, Tara, additional, Hoskin, Peter, additional, Johnstone, Candice, additional, Recht, Abram, additional, Menten, Johan, additional, Oldenburger, Eva, additional, van der Linden, Yvette M., additional, van der Velden, Joanne M., additional, Nguyen, Quynh-Nhu, additional, Simone II, Charles B., additional, Johnstone, Peter, additional, Lutz, Stephen, additional, Milton, Lauren, additional, Andratschke, Nicolaus, additional, Willmann, Jonas, additional, Kazmierska, Joanna, additional, Spałek, Mateusz, additional, Marta, Gustavo N., additional, Chow, Edward, additional, and Raman, Srinivas, additional

Published
2023
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13. Corrigendum: MRI-guided focal or integrated boost high dose rate brachytherapy for recurrent prostate cancer

Author

Ménard, Cynthia, primary, Navarro-Domenech, Inmaculada, additional, Liu, Zhihu (Amy), additional, Joseph, Lisa, additional, Barkati, Maroie, additional, Berlin, Alejandro, additional, Delouya, Guila, additional, Taussky, Daniel, additional, Beauchemin, Marie-Claude, additional, Nicolas, Benedicte, additional, Kadoury, Samuel, additional, Rink, Alexandra, additional, Raman, Srinivas, additional, Sundaramurthy, Aravindhan, additional, Weersink, Robert, additional, Beliveau-Nadeau, Dominic, additional, Helou, Joelle, additional, and Chung, Peter, additional

Published
2022
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14. MRI-guided focal or integrated boost high dose rate brachytherapy for recurrent prostate cancer

Author

Ménard, Cynthia, primary, Navarro-Domenech, Inmaculada, additional, Liu, Zhihu (Amy), additional, Joseph, Lisa, additional, Barkati, Maroie, additional, Berlin, Alejandro, additional, Delouya, Guila, additional, Taussky, Daniel, additional, Beauchemin, Marie-Claude, additional, Nicolas, Benedicte, additional, Kadoury, Samuel, additional, Rink, Alexandra, additional, Raman, Srinivas, additional, Sundaramurthy, Aravindhan, additional, Weersink, Robert, additional, Beliveau-Nadeau, Dominic, additional, Helou, Joelle, additional, and Chung, Peter, additional

Published
2022
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15. 1709: Online adaptive radiation magnetic resonance-guided radiotherapy: current implementation in Spain

Author

Méndez, Beatriz Debén, Navarro-Domenech, Inmaculada, Aller, Rafael Rosel, Martinez, Concepción Huertas, Gracia, Carlos Luis Ferrer, Corral, Patricia Arroyo, Vilela, Beatriz Sánchez, Serrano, Antonio Lozano, Martínez, Daniel Camacho, Portillo, Elisabet González Del, Roldán, Marta Rodríguez, Botella, Maria Isabel Garrido, Martinez, Abrahams Alexis Ocanto, Cantero, Mercedes González, Ubach, Macarena Teja, Torres, Celia García, and López, Rosa María Morera

Published
2024
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