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Your search keyword '"Navarro‐Pando, José M."' showing total 21 results
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21 results on '"Navarro‐Pando, José M."'

2. Blockade of the NLRP3 inflammasome improves metabolic health and lifespan in obese mice

Author

Cañadas-Lozano, Diego, Marín-Aguilar, Fabiola, Castejón-Vega, Beatriz, Ryffel, Bernhard, Navarro-Pando, José M., Ruiz-Cabello, Jesús, Alcocer-Gómez, Elísabet, Bullón, Pedro, and Cordero, Mario D.

Abstract

Aging is the major risk factor for many metabolic chronic diseases. Several metabolic pathways suffer a progressive impairment during aging including body composition and insulin resistance which are associated to autophagy dysfunction and increased inflammation. Many of these alterations are aggravated by non-healthy lifestyle such as obesity and hypercaloric diet which have been shown to accelerate aging. Here, we show that the deleterious effect of hypercaloric diets is reverted by the NLRP3 inflammasome inhibition. NLRP3 deficiency extends mean lifespan of adult mice fed a high-fat diet. This lifespan extension is accompanied by metabolic health benefits including reduced liver steatosis and cardiac damage, improved glucose and lipid metabolism, and improved protein expression profiles of SIRT-1, mTOR, autophagic flux, and apoptosis. These findings suggest that the suppression of NLRP3 prevented many age-associated changes in metabolism impaired by the effect of hypercaloric diets.

Published
2024
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5. Inhibition of the NLRP3 inflammasome improves lifespan in animal murine model of Hutchinson–Gilford Progeria

Author

González‐Dominguez, Alvaro, primary, Montañez, Raúl, additional, Castejón‐Vega, Beatriz, additional, Nuñez‐Vasco, Jéssica, additional, Lendines‐Cordero, Débora, additional, Wang, Chun, additional, Mbalaviele, Gabriel, additional, Navarro‐Pando, José M, additional, Alcocer‐Gómez, Elísabet, additional, and Cordero, Mario D, additional

Published
2021
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6. VRK1 (Y213H) homozygous mutant impairs Cajal bodies in a hereditary case of distal motor neuropathy

Author

Junta de Castilla y León, Ministerio de Educación (España), Ministerio de Economía y Competitividad (España), Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), European Commission, Marcos, Ana T., Martín-Doncel, Elena, Morejón-García, Patricia, Marcos-Alcalde, Íñigo, Gómez-Puertas, Paulino, Segura‐Puimedon, María, Armengol, Lluís, Navarro‐Pando, José M., Lazo, Pedro A., Junta de Castilla y León, Ministerio de Educación (España), Ministerio de Economía y Competitividad (España), Agencia Estatal de Investigación (España), Ministerio de Ciencia, Innovación y Universidades (España), European Commission, Marcos, Ana T., Martín-Doncel, Elena, Morejón-García, Patricia, Marcos-Alcalde, Íñigo, Gómez-Puertas, Paulino, Segura‐Puimedon, María, Armengol, Lluís, Navarro‐Pando, José M., and Lazo, Pedro A.

Abstract

[Background]: Distal motor neuropathies with a genetic origin have a heterogeneous clinical presentation with overlapping features affecting distal nerves and including spinal muscular atrophies and amyotrophic lateral sclerosis. This indicates that their genetic background is heterogeneous., [Patient and methods]: In this work, we have identified and characterized the genetic and molecular base of a patient with a distal sensorimotor neuropathy of unknown origin. For this study, we performed whole‐exome sequencing, molecular modelling, cloning and expression of mutant gene, and biochemical and cell biology analysis of the mutant protein., [Results]: A novel homozygous recessive mutation in the human VRK1 gene, coding for a chromatin kinase, causing a substitution (c.637T > C; p.Tyr213His) in exon 8, was detected in a patient presenting since childhood a progressive distal sensorimotor neuropathy and spinal muscular atrophy syndrome, with normal intellectual development. Molecular modelling predicted this mutant VRK1 has altered the kinase activation loop by disrupting its interaction with the C‐terminal regulatory region. The p.Y213H mutant protein has a reduced kinase activity with different substrates, including histones H3 and H2AX, proteins involved in DNA damage responses, such as p53 and 53BP1, and coilin, the scaffold for Cajal bodies. The mutant VRK1(Y213H) protein is unable to rescue the formation of Cajal bodies assembled on coilin, in the absence of wild‐type VRK1., [Conclusion]: The VRK1(Y213H) mutant protein alters the activation loop, impairs the kinase activity of VRK1 causing a functional insufficiency that impairs the formation of Cajal bodies assembled on coilin, a protein that regulates SMN1 and Cajal body formation.

Published
2020

7. Inhibition of the NLRP3 inflammasome prevents ovarian aging

Author

Navarro-Pando, José M., primary, Alcocer-Gómez, Elísabet, additional, Castejón-Vega, Beatriz, additional, Navarro-Villarán, Elena, additional, Condés-Hervás, Mónica, additional, Mundi-Roldan, María, additional, Muntané, Jordi, additional, Pérez-Pulido, Antonio J., additional, Bullon, Pedro, additional, Wang, Chun, additional, Hoffman, Hal M., additional, Sanz, Alberto, additional, Mbalaviele, Gabriel, additional, Ryffel, Bernhard, additional, and Cordero, Mario D., additional

Published
2021
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12. Inhibition of the NLRP3 inflammasome prevents ovarian aging

Author

Navarro-Pando, José M., primary, Alcocer-Gómez, Elísabet, additional, Castejón-Vega, Beatriz, additional, Muntané, Jordi, additional, Bullon, Pedro, additional, Wang, Chun, additional, Hoffman, Hal M., additional, Sanz, Alberto, additional, Mbalaviele, Gabriel, additional, Ryffel, Bernhard, additional, and Cordero, Mario D., additional

Published
2020
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13. Effect of coenzyme Q10 on psychopathological symptoms in fibromyalgia patients

Author

Junta de Andalucía, Alcocer-Gómez, Elísabet, Culic, Ognjen, Navarro-Pando, José M., Sánchez-Alcázar, José Antonio, Junta de Andalucía, Alcocer-Gómez, Elísabet, Culic, Ognjen, Navarro-Pando, José M., and Sánchez-Alcázar, José Antonio

Abstract

Fibromyalgia (FM) is a common chronic pain syndrome accompanied by a myriad of variable physical and psychopathological symptoms such as fatigue, muscle stiffness, sleep disorders, morning tiredness, cognitive complaints, as well as depression and anxiety.

Published
2017

15. Could NLRP3–Inflammasome Be a Cardiovascular Risk Biomarker in Acute Myocardial Infarction Patients?

Author

Bullón, Pedro, primary, Cano-García, Francisco J., additional, Alcocer-Gómez, Elísabet, additional, Varela-López, Alfonso, additional, Roman-Malo, Lourdes, additional, Ruiz-Salmerón, Rafael J., additional, Quiles, José L., additional, Navarro-Pando, José M., additional, Battino, Maurizio, additional, Ruiz-Cabello, Jesús, additional, Jiménez-Borreguero, Luis J., additional, and Cordero, Mario D., additional

Published
2017
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19. Mutation in cytochrome b gene of mitochondrial DNA in a family with fibromyalgia is associated with NLRP3-inflammasome activation

Author

Cordero, Mario D, primary, Alcocer-Gómez, Elísabet, additional, Marín-Aguilar, Fabiola, additional, Rybkina, Tatyana, additional, Cotán, David, additional, Pérez-Pulido, Antonio, additional, Alvarez-Suarez, José Miguel, additional, Battino, Maurizio, additional, Sánchez-Alcazar, José Antonio, additional, Carrión, Angel M, additional, Culic, Ognjen, additional, Navarro-Pando, José M, additional, and Bullón, Pedro, additional

Published
2015
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21. Effect of Coenzyme Q 10 on Psychopathological Symptoms in Fibromyalgia Patients.

Author

Alcocer-Gómez E, Culic O, Navarro-Pando JM, Sánchez-Alcázar JA, and Bullón P

Subjects
Administration, Oral, Adult, Body Mass Index, Double-Blind Method, Fibromyalgia metabolism, Humans, Middle Aged, Treatment Outcome, Ubiquinone therapeutic use, Fibromyalgia drug therapy, Fibromyalgia psychology, Psychotropic Drugs therapeutic use, Ubiquinone analogs & derivatives
Published
2017
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