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510 results on '"Naumovski, Nenad"'

9. Bacteriocins Production Using Whey

Author

Ali, Anwar, Tahir, Aleena, Khalid, Waseem, Khan, Ahmal, Zeng, Xin-An, Jani, Rati, Naumovski, Nenad, Manzoor, Muhammad Faisal, Poonia, Amrita, editor, and Trajkovska Petkoska, Anka, editor

Published
2023
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19. Microbially mediated phenolic catabolites exert differential genoprotective activities in normal and adenocarcinoma cell lines.

Author

Murphy, Brian Óg, Latimer, Cheryl, Dobani, Sara, Pourshahidi, L. Kirsty, Fontana, Massimilano, Ternan, Nigel. G., McDougall, Gordon, Rowland, Ian, Pereira-Caro, Gema, Tuohy, Kieran M., Del Rio, Daniele, Almutairi, Tahani M., Crozier, Alan, Naumovski, Nenad, and Gill, Chris I. R.

Subjects
NUCLEAR factor E2 related factor, PROPIONIC acid, BENZOIC acid, DNA repair, CELL lines
Abstract

Age-associated decline of nuclear factor erythroid 2-related factor 2 (Nrf2) activity and DNA repair efficiency leads to the accumulation of DNA damage and increased risk of cancer. Understanding the mechanisms behind increased levels of damaged DNA is crucial for developing interventions to mitigate age-related cancer risk. Associated with various health benefits, (poly)phenols and their microbially mediated phenolic catabolites represent a potential means to reduce DNA damage. Four colonic-microbiota-derived phenolic catabolites were investigated for their ability to reduce H2O2-induced oxidative DNA damage and modulate the Nrf2-Antixoidant Response Element (ARE) pathway, in normal (CCD 841 CoN) and adenocarcinoma (HT29) colonocyte cell lines. Each catabolite demonstrated significant (p <.001) genoprotective activity and modulation of key genes in the Nrf2-ARE pathway. Overall, the colon-derived phenolic metabolites, when assessed at physiologically relevant concentrations, reduced DNA damage in both normal and adenocarcinoma colonic cells in response to oxidative challenge, mediated in part via upregulation of the Nrf2-ARE pathway. [ABSTRACT FROM AUTHOR]

Published
2024
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28. Rapid Purification and Quantification of Intestinal and Fecal Short-Chain Fatty Acids by Solid-Phase Extraction Using Bond Elut Plexa.

Author

Zheng, Xing, Chen, Tao, Li, Wanli, Wang, Kai, Xue, Xiaofeng, Naumovski, Nenad, and Peng, Wenjun

Subjects
SHORT-chain fatty acids, FLAME ionization detectors, GASTROINTESTINAL contents, GAS chromatography, METABOLIC disorders
Abstract

Short-chain fatty acids (SCFAs) in feces are inextricably linked to intestinal homeostasis and can be used as potential markers for metabolic diseases. In this study, an efficient and simple method was developed for the purification of SCFAs without the need for derivatization of the samples. The SCFAs (acetic, propionic, isobutyric, butyric, isovaleric, valeric, and hexanoic acid) were extracted from a small amount (50 mg) of fecal and intestinal samples using acetone combined with solid phase extraction column (Bond Elut Plexa) enrichment. Quantitative analysis was performed using gas chromatography with a flame ionization detector. The developed method has shown very good limits of detection (LOD, 0.11–0.36 μM) and limits of quantification (LOQ, 0.38–1.21 μM) with excellent linearity (R2 ≥ 0.9998), good recovery (98.34–137.83%), and high reproducibility (RSD ≤ 1.30). The applicability of this method was also demonstrated by testing the fecal and cecum contents of different species from mammals (mice, pigs) to insects (honeybees). The technique is highly suitable for analyzing complex, small amounts of intestinal and fecal SCFAs. [ABSTRACT FROM AUTHOR]

Published
2024
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29. Reliability of an "At-Home" Method for Monitoring Resting and Reactive Autonomic Nervous System Activity in Children: A Pilot Study.

Author

Venn, Rachel, Northey, Joseph M., Naumovski, Nenad, and McKune, Andrew

Subjects
AUTONOMIC nervous system physiology, EXERCISE physiology, PEARSON correlation (Statistics), RESEARCH funding, HEART rate monitoring, PILOT projects, DESCRIPTIVE statistics, HEART beat, TELEMEDICINE, STATISTICAL reliability, CONFIDENCE intervals, COMPARATIVE studies, DATA analysis software, RELIABILITY (Personality trait), CHILDREN
Abstract

Background: Heart rate variability (HRV), an index of the functional status of the autonomic nervous system (ANS), provides an opportunity for early detection of ANS dysfunction. Lower resting, vagally related HRV parameters are associated with increased risk of physical and mental illness. External factors influencing the ANS, such as the testing environment, may impact the interpretation of HRV. This study's main aim was to determine the reliability of HRV resting and reactivity tests performed at home with children aged 4–9 years. Methods: Fourteen healthy children (female n = 8) aged 6.8 ± 1.5 years participated. Two HRV tests were performed at home via online supervision 7 days apart using a Polar H10 heart rate monitor. The absolute and relative reliability of the pre-exercise resting (5 min) and sub-maximal exercise step test recovery (4 × 30 s segments) HRV time and frequency domains were calculated. Results: The Pearson correlation coefficients for day 1 versus day 7 for the vagal activity HRV domains (RMSSD log) at rest and in the first 30 s and 30–60 s of recovery indicated good-to-excellent relative reliability (r > 0.8, p < 0.01). Absolute reliability was moderate for the resting RMSSD log, with a coefficient of variation (CV) of 5.2% (90% CI: 3.9, 7.8%), high for the first 30 s of standing recovery, with a CV of 10.7% (90% CI: 8.2, 15.7%), and moderate for 30–60 s of recovery, with a CV of 8.7% (90% CI: 6.6, 12.9%). Conclusions: The findings of this pilot study indicate that the resting and exercise recovery HRV measures of vagal activity can be measured reliably at home in children. This represents a novel "at-home" protocol for monitoring ANS health and development in children. [ABSTRACT FROM AUTHOR]

Published
2024
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