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476 results on '"National Taiwan University [Taiwan] (NTU)"'

1. Temperature stress and redox homeostasis: The synergistic network of redox and chaperone system in response to stress in plants

Author: Florence Vignols, Hui-Chen Wu, Tsung-Luo Jinn, Department of Biological Sciences and Technology [Tainan], National University of Tainan (NUTN), National Taiwan University [Taiwan] (NTU)-National Taiwan University [Taiwan] (NTU), National Taiwan University [Taiwan] (NTU), Biochimie et Physiologie Moléculaire des Plantes (BPMP), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut National de la Recherche Agronomique (INRA)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Department of Life Science and Institute of Plant Biology, National Taiwan University, Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Department of Biological Sciences and Technology, National University of Tainan, and Université de Montpellier (UM)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro)-Institut National de la Recherche Agronomique (INRA)-Centre National de la Recherche Scientifique (CNRS)
Subjects: 0106 biological sciences, stress thermique, réaction redox, Redox proteins, [SDV]Life Sciences [q-bio], Chaperone, Protein aggregation, medicine.disease_cause, 01 natural sciences, Redox, heat stress, 03 medical and health sciences, Heat shock protein, Calcium ion, medicine, oxidative stress, [SDV.BV]Life Sciences [q-bio]/Vegetal Biology, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, Reactive oxygen species, calcium, biology, Heat shock proteins, stress oxydatif, oxydoréduction, Cell biology, oxidoreduction, chemistry, 13. Climate action, Chaperone (protein), biology.protein, Signal transduction, Homeostasis, Oxidative stress, 010606 plant biology & botany
Abstract: A remarkable number of strategies has been developed by living organisms to mitigate conflict with environmental changes. The global environment rising with ambient temperature has a wide range of effects on plant growth, and therefore activation of various molecular defenses before the appearance of heat damage. Evidence revealed key components of stress that trigger enhanced tolerance, and some determinants for plant tolerance have been identified. The interplay between heat shock proteins (HSP) and redox proteins is supposed to be vital for the survival under extreme stress conditions. Any circumstance in which cellular redox homeostasis is disrupted can lead to the generation of reactive oxygen species (ROS) that are continuously generated in cells as an unavoidable consequence of aerobic life. Integrative network analysis of synthetic genetic interactions, protein-protein interactions, and functional annotations revealed many new functional processes linked to heat stress (HS) and oxidative stress (OS) tolerance, implicated upstream regulators activated by the either HS or OS, and revealed new connections between them. We present different models of acquired stress resistance to interpret the condition-specific involvement of genes. Considering the basic concepts and the recent advances, the following subsections provide an overview of calcium ion (Ca2+) and ROS interplay in abiotic signaling pathways; further we introduce several examples of chaperone and redox proteins that respond the change of cellular redox status under environmental circumstances. Thus, the involvement or contribution of redox proteins through the functional switching in conjunction with the HSP that prevent heat- and oxidative-induced protein aggregation in plants.
Published: 2019

2. Probing structural and electronic properties of h-BN by HRTEM and STM

Author: Van Dong Pham, Hakim Amara, Christian Ricolleau, Jérôme Lagoute, P. Lavenus, Damien Alloyeau, Guillaume Wang, Amandine Andrieux, Nelly Dorval, Pai Woei Wu, Frédéric Fossard, Annick Loiseau, Ouafi Mouhoub, Laboratoire d'étude des microstructures [Châtillon] (LEM - ONERA - CNRS), Centre National de la Recherche Scientifique (CNRS)-ONERA, Mathématique et Physique Quantique (MPQ), Centre National de la Recherche Scientifique (CNRS), Laboratoire Matériaux et Phénomènes Quantiques (MPQ (UMR_7162)), Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), ONERA - The French Aerospace Lab [Palaiseau], ONERA-Université Paris Saclay (COmUE), ONERA - The French Aerospace Lab [Châtillon], National Taiwan University [Taiwan] (NTU), ONERA-Centre National de la Recherche Scientifique (CNRS), ONERA, Laboratoire d'étude des microstructures ( LEM - ONERA - CNRS ), ONERA-Centre National de la Recherche Scientifique ( CNRS ), Mathématique et Physique Quantique ( MPQ ), Centre National de la Recherche Scientifique ( CNRS ), Laboratoire Matériaux et Phénomènes Quantiques ( MPQ ), Université Paris Diderot - Paris 7 ( UPD7 ), Matériaux et Phénomènes Quantiques ( MPQ ), Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ), ONERA - The French Aerospace Lab ( Palaiseau ), ONERA - The French Aerospace Lab ( Chatillon ), and National Taiwan University [Taiwan] ( NTU )
Subjects: Materials science, Microscope, aberration-corrected TEM, Stacking, Nanotechnology, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, law.invention, Nanomaterials, electron beam irradiation, law, hexagonal boron nitride, [PHYS.COND]Physics [physics]/Condensed Matter [cond-mat], High-resolution transmission electron microscopy, [PHYS]Physics [physics], [ PHYS ] Physics [physics], Graphene, Doping, Heterojunction, 021001 nanoscience & nanotechnology, 0104 chemical sciences, Van Der Walls heterostructures, Scanning tunneling microscope, 0210 nano-technology, [ PHYS.COND ] Physics [physics]/Condensed Matter [cond-mat]
Abstract: After the discovery of graphene and its consequences in the field of nanoscience and nanomaterials, there has been a growing interest in 2D materials and also their vertical stacking due to unique properties and potential applications.[1] For instance, it was shown the transport properties of exfoliated graphene supported by hexagonal boron nitride (h-BN) could approach the intrinsic graphene limits.[2] Nevertheless, studying the structural properties of 2D materials and 2D heterostructures is crucial to understand their physical and chemical properties. Our motivations have been to exploit state of the art aberration-corrected high resolution transmission electron microscopy (HRTEM) and scanning tunneling microscopy (STM) to study the structure and electronic properties of graphene (G), h-BN and G/h-BN heterostructures. HRTEM analyses were conducted with a JEOL ARM microscope equipped together with a cold FEG, an aberration corrector for the objective lens and a One view camera (Gatan). Notably, we used high-speed atomic-scale imaging to study with unprecedented dynamics (up to 25 fps) the nucleation and growth mechanisms of triangular holes in h-BN under beam irradiation (Figure 1). The direct observation of B and N atom sputtering and surface reconstruction processes allow understanding how the triangular shape and orientation of holes are maintained during the growth. Interestingly, by studying the effects of the electron dose and the number of BN layers, we demonstrate that these atomic-scale processes are simultaneously driven by kinetic and thermodynamic effects. Further works are in progress to study the stability of h-BN/G stacking under electron-beam irradiation. STM analyses were carried out with low temperature STM at 4 K, on 2D heterostructures that consist in a few layers of graphene doped with nitrogen on thick exfoliated flakes of BN deposited on SiO2. Remarkably, we show that STM allows identifying and characterizing ionization defects within the BN flakes below the graphene layers (Figure 2). This study opens new avenues to probe the electronic interactions between this two stacked materials. Keywords: hexagonal boron nitride; aberration-corrected TEM; electron beam irradiation; van der walls heterostructures
Published: 2016

3. Multiple nuclear and mitochondrial genotyping identifies emperors and large-eye breams (Teleostei: Lethrinidae) from New Caledonia and reveals new large-eye bream species

Author: Dominique Ponton, Adeline Collet, Philippe Borsa, Wei-Jen Chen, Laure Carassou, UR 227, IRD UR 227, centre IRD de Montpellier, Biocomplexité des écosystèmes coralliens de l'Indo-Pacifique (CoReUS2), Institut de Recherche pour le Développement (IRD [Nouvelle-Calédonie]), Inst. Oceanogr. National Taiwan University, Marine Phylogenomics Lab, National Taiwan University [Taiwan] (NTU)-National Taiwan University [Taiwan] (NTU), and IRD, ZoNéCo, Fonds Pacifique pour de développement
Subjects: 0106 biological sciences, Identification, Species complex, Zoology, [SDV.BID]Life Sciences [q-bio]/Biodiversity, Biological species concept, 010603 evolutionary biology, 01 natural sciences, Biochemistry, 03 medical and health sciences, Larvae, PCR markers, 14. Life underwater, Lethrinidae, Ecology, Evolution, Behavior and Systematics, 030304 developmental biology, 0303 health sciences, biology, Ecology, Reproductive isolation, Gymnocranius, biology.organism_classification, Fish, Cryptic species, Indo-Pacific, Taxonomy (biology), Lethrinus, Meristics
Abstract: International audience; Species identification is fundamental to address questions about community ecology, biodiversity, conservation and resource management, at any life history stage. Current studies on fish larval ecology of tropical species are hampered by the lack of reliable and effective tools for identifying larvae at the species level. Emperors and large-eye breams comprise fish species from the perciform fish family Lethrinidae. They inhabit coastal and coral-reef habitats of the tropical Indo-Pacific, and they are important fishery resources. Their taxonomy is considered difficult and identification to species is often problematic. Lethrinidae larvae and juveniles can be identified on the basis of meristic counts at the subfamily level, but no further. In this study, we developed a set of polymorphic PCR markers (size polymorphisms at the intron regions from 4/5 nuclear protein-coding genes and single-strand conformation polymorphism of a 205-bp fragment at the mitochondrial 16S rRNA locus), to characterize 341 specimens from 21 Lethrinidae species from New Caledonia (southwestern tropical Pacific). A genetic data-bank was constructed using the genotypes screened from the multiple gene loci of adult or sub-adult specimens used as references for these species. The 16S rRNA gene fragment was able to differentiate species for the genus Lethrinus, but it provided little diagnostic resolution among different species within the genus Gymnocranius. A combination of the 16S rRNA marker and 4 nuclear markers developed herein allowed to sort out species within Gymnocranius spp. from New Caledonia. Using genotype distributions at nuclear loci to test for reproductive isolation, we found that three apparently undescribed large-eye bream species may exist, provisionally referred to as Gymnocranius sp. A, sp. B and sp. C. Subsequent genotyping of 137 Lethrinidae larvae collected from the bays of the Noumea peninsula, New Caledonia, found a total of three species (Lethrinus genivittatus, L. olivaceus and Gymnocranius sp. A).
Published: 2010

4. Stalagmite-inferred hydroclimate changes in northern Italy during Allerød/Younger Dryas transition

Author: Chieh-Ju Hsieh, Hsun-Ming Hu, Chuan-Chou Shen, Véronique Michel, Patricia Valensi, Elisabetta Starnini, Marta Zunino, Department of Atmospheric Sciences, National Taiwan University, High-Precision Mass Spectrometry and Environment Change Laboratory (HISPEC), National Taiwan University [Taiwan] (NTU), Research Center for Future Earth, National Taiwan University, Culture et Environnements, Préhistoire, Antiquité, Moyen-Age (CEPAM), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Géoazur (GEOAZUR 7329), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Histoire naturelle de l'Homme préhistorique (HNHP), Muséum national d'Histoire naturelle (MNHN)-Université de Perpignan Via Domitia (UPVD)-Centre National de la Recherche Scientifique (CNRS), Department of Civilizations and Forms of Knowledge, University of Pisa, and Toirano Cave, 17055, Toirano
Subjects: [SDU]Sciences of the Universe [physics], [SHS]Humanities and Social Sciences
Abstract: The Younger Dryas (YD), a 1200-year-long cooling event interrupting the warm Bølling-Allerød period, started from 12,870 ± 30 yr BP (2σ, before 1950 C.E.). Here we present decadal-resolved stalagmite BA18-2 multi-proxy records from Bàsura cave, northern Italy. The StalAge age-depth model with 8 U-Th dates with 2-sigma errors of ± 26-193 yrs shows that BA18-2 encompasses Allerød/YD transition, from 14,038 ± 92 to 12,090 ± 54 yr BP. Oxygen isotope data fluctuate between -7.16‰ and -3.68‰, with a clear 2.4‰ increase during the YD onset at 12,870 ± 30 yr BP. Stalagmite BA18-2 Sr/Ca and Ba/Ca linger from 0.060-0.085 mmol/mol and 6.4-9.1 µmol/mol, respectively, from 14,038 ± 92 to 12,681 ± 55 yr BP, ~ 2 centuries after the beginning of YD. A clear 160-year-long two-step increase in both Sr/Ca and Ba/Ca records started from 12,681 ± 55 yr BP, which is a 200-yr lag relative to the timing of BA18-2 oxygen isotope increasing trend. We argue that the oxygen isotope could be governed by temperature, moisture source, and/or rainfall amount; while, the Sr/Ca and Ba/Ca ratios predominantly reflect precipitation change. Our results might suggest asynchronous thermal and hydrological changes in northern Italy during the Allerøod/YD transition.
Published: 2023

5. Chryseobacterium oryctis sp. nov., isolated from the gut of the beetle Oryctes rhinoceros, and Chryseobacterium kimseyorum sp. nov., isolated from a stick insect rearing cage

Author: Matan Shelomi, Chiao-Jung Han, Wen-Ming Chen, Hsin-Kuang Chen, Shwu-Jen Liaw, Estelle Mühle, Dominique Clermont, National Taiwan University [Taiwan] (NTU), National Kaohsiung University of Science and Technology [Taiwan], Collection de l'Institut Pasteur (CIP), Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité), and This study was supported by the Ministry of Science and Technology, Taiwan (Award MOST-109-2311-B-002-016-MY3).
Subjects: Chryseobacterium, 16S, [SDV]Life Sciences [q-bio], ANI, General Medicine, rpoB and taxonomic description, Microbiology, Ecology, Evolution, Behavior and Systematics
Abstract: Two strains of Chryseobacterium identified from different experiments are proposed to represent new species. Strain WLa1L2M3T was isolated from the digestive tract of an Oryctes rhinoceros beetle larva. Strain 09-1422T was isolated from a cage housing the stick insect Eurycantha calcarata. Sequence analysis of the 16S rRNA and rpoB genes found both strains to be similar but not identical to other Chryseobacterium species. Whole-genome sequencing suggested the isolates represent new species, with average nucleotide identity values ranging from 74.6 to 80.5 %. Genome-to-genome distance calculations produced values below 25.3 %, and digital DNA–DNA hybridization values were 13.7–29.9 %, all suggesting they are distinct species. The genomic DNA G+C content of WLa1L2M3T is approximately 32.53 %, and of 09-1422T is approximately 35.89 %. The predominant cellular fatty acids of strain WLa1L2M3T are C15 : 0 iso, summed feature 9 (C16 : 0 10OH or C17 : 1 iso ω6c), C17 : 0 iso 3OH, summed feature 3 (C16 : 1 ω7c and/or C16 : 1 ω6c), C15 : 0 iso 3OH, C15 : 0 anteiso and C13 : 0 iso, and those of strain 09-1422T are C15 : 0 iso, summed feature 3 (C16 : 1 ω7c and/or C16 : 1 ω6c), C17 : 0 iso 3OH, C15 : 0 anteiso, C15 : 0 iso 3OH, C16 : 1 ω7c, C17 : 0 2OH and C18 : 0. In addition, physiological and biochemical tests revealed phenotypic differences from related Chryseobacterium type strains. These cumulative data indicate that the two strains represent novel species of the genus Chryseobacterium for which the names Chryseobacterium oryctis sp. nov. and Chryseobacterium kimseyorum sp. nov. are proposed with WLa1L2M3T (=BCRC 81350T=JCM 35215T=CIP 112035T) and 09-1422T (=UCDFST 09-1422T=BCRC 81359T=CIP 112165T), as type strains, respectively.
Published: 2023

6. La séquence archéologique du Pléistocène moyen de la grotte du Lazaret, France : Nouvelles datations par U-Th et par le paléomagnétisme du plancher stalagmitique supérieur

Author: Chou, Yu-Min, Michel, Véronique, Yang, Huihui, Kan, Yu-Chun, Hu, Hsun-Ming, Yu, Tsai-Luen, Valensi, Patricia, Cauche, Dominique, Moncel, Marie-Hélène, de Lumley, Henry, Shen, Chuan-Chou, Southern University of Science and Technology (SUSTech), Culture et Environnements, Préhistoire, Antiquité, Moyen-Age (CEPAM), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Géoazur (GEOAZUR 7329), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), University College of London [London] (UCL), National Taiwan University [Taiwan] (NTU), National Kaohsiung Marine University [Taïwan] (NKMU), Histoire naturelle de l'Homme préhistorique (HNHP), Muséum national d'Histoire naturelle (MNHN)-Université de Perpignan Via Domitia (UPVD)-Centre National de la Recherche Scientifique (CNRS), Institut de Paléontologie Humaine (IPH), Fondation I.P.H-Centre National de la Recherche Scientifique (CNRS), Léa Drieu, Claire Delhon, and Martine Regert
Subjects: Paléolithique inférieur-moyen, [SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, Datation U-Th, [SDU]Sciences of the Universe [physics], Blake, post-Blake, plancher stalagmitique, paléomagnétisme
Abstract: International audience
Published: 2023

7. Datations radioisotopiques (U-Th, U-Pb) et paléodosimétrique (ESR) des plus anciens sites préhistoriques des Alpes-Maritimes : la grotte du Vallonnet, le site de plein air de Terra Amata et la grotte du Lazaret

Author: Michel, Véronique, Shen, Guanjun, Shen, Chuan-Chou, Duval, Mathieu, Woodhead, Jon, Chou, Yu-Min, Hu, Hsun-Ming, Wu, Chung-Che, Kan, Yu-Chun, Yang, Huihui, Yu, Tsai-Luen, Gallet, Sylvain, Valensi, Patricia, Culture et Environnements, Préhistoire, Antiquité, Moyen-Age (CEPAM), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Géoazur (GEOAZUR 7329), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), College of Geographical Sciences, Nanjing Normal University (NNU), High-Precision Mass Spectrometry and Environment Change Laboratory (HISPEC), National Taiwan University [Taiwan] (NTU), Consorcio del Centro Nacional de Investigación de La Evolución Humana (CENIEH), School of Earth Sciences [Melbourne], Faculty of Science [Melbourne], University of Melbourne-University of Melbourne, Center of Marine Magnetism, Department of Ocean Science and Engineering (CCM), College of Marine Sciences and Engineering, Nanjing Normal University, Nanjing Jiangsu, Center of Marine Magnetism, Department of Ocean Science and Engineering, Marine Industry and Engineering Research Center, National Academy of Marine Research, Kaohsiung, Histoire naturelle de l'Homme préhistorique (HNHP), and Muséum national d'Histoire naturelle (MNHN)-Université de Perpignan Via Domitia (UPVD)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Paléolithique inférieur-moyen, hominines, [SDU.STU.ST]Sciences of the Universe [physics]/Earth Sciences/Stratigraphy, U-Pb, Datation, U-Th, ESR, [SHS]Humanities and Social Sciences
Abstract: International audience; L’extrême sud-est de la France renferme d’importants sites du Paléolithique inférieur. Ils permettent de mieux appréhender le comportement et le mode de vie des plus anciens hominines d’Europe occidentale. Différents programmes de datations ont été réalisés sur les trois principaux sites préhistoriques des Alpes-Maritimes. La grotte du Vallonnet, le plus ancien des sites de la région, à Roquebrune-Cap-Martin (43°45’51”N, 7°28’15”E), a livré des outils archaïques de culture oldowayenne associés à des faunes épivillafranchiennes et dont certains ossements portent des marques évidentes de découpe. Les dernières datations à 1,22-1,18 Maobtenues par la méthode U-Pb sont présentées ici. L’occupation humaine du site se situe au cours de l’épisode paléomagnétique Cobb Mountain soit au cours du stade isotopique marin MIS 36-35 (MIS : marine isotope stage), avec un climat frais et sec à la base de la séquence archéologique suivi d’un climat tempéré et humide d’après les données de la paléontologie et de la palynologie. D’autres occupations humaines plus tardives sont enregistrées dans la région, avec la présence de populations hominines sur le site de plein air de Terra Amata à Nice (43°41’52’’N, 7°17’21’’E), dont nous rappelons ici l’ancienne datation par ESR à environ 380 ka(Yokoyama et al., 1985) et les résultats de la biochronologie situant les occupations au cours de la période tempérée du MIS 11. Les Homo erectus ont occupé le site à plusieurs reprises, à la belle saison, et y ont laissé une industrie du Paléolithique inférieur rapportée à l’Acheuléen. Enfin, des groupes des derniers Homo erectus occupent de façon répétitive la grotte du Lazaret à Nice (43°41’25’’N, 7°17’42’’E). Les dépôts archéologiques ont livré une industrie de l’Acheuléen final, associée à des restes fauniques portant de nombreuses marques anthropiques et près d’une trentaine de restes humains. La faune indique un climat frais et humide, au cours du stade MIS 6. Les dernières datations, présentées ici et obtenues par les méthodes ESR, U-Th et par le paléomagnétisme sur les niveaux pléistocènes du site, permettent de situer chronologiquement les niveaux archéologiques entre 190 ka et 120 ka.
Published: 2023

8. Influence of Forced Convection on Columnar Microstructure during Directional Solidification of Al - Ni Alloys

Author: Chung-Wen Lan, Qiu-Sheng Liu, Guillaume Reinhart, T. P. Lyubimova, Bernard Roux, Binghong Zhou, Henri Nguyen-Thi, Bernard Billia, Institut des Matériaux, de Microélectronique et des Nanosciences de Provence ( IM2NP ), Aix Marseille Université ( AMU ) -Université de Toulon ( UTLN ) -Centre National de la Recherche Scientifique ( CNRS ), Chinese Academy of Sciences [Changchun Branch] ( CAS ), National Taiwan University [Taiwan] ( NTU ), Institute of Continuous Media Mechanics of the RAS ( ICMM ), Ural Branch of Russian Academy of Sciences ( UB RAS ), L'avion jaune, Institut des Matériaux, de Microélectronique et des Nanosciences de Provence (IM2NP), Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Chinese Academy of Sciences [Changchun Branch] (CAS), National Taiwan University [Taiwan] (NTU), Institute of Continuous Media Mechanics of the RAS (ICMM), Ural Branch of Russian Academy of Sciences (UB RAS), and Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Materials science, Crucible, 02 engineering and technology, 01 natural sciences, Physics::Fluid Dynamics, Condensed Matter::Materials Science, 0103 physical sciences, Fluid dynamics, Coupling (piping), General Materials Science, Composite material, ComputingMilieux_MISCELLANEOUS, Directional solidification, 010302 applied physics, Natural convection, 020502 materials, Mechanical Engineering, Metallurgy, [CHIM.MATE]Chemical Sciences/Material chemistry, Condensed Matter Physics, Microstructure, Forced convection, Temperature gradient, 0205 materials engineering, Mechanics of Materials, [ CHIM.MATE ] Chemical Sciences/Material chemistry
Abstract: This paper presents a summary of cellular and dendritic morphologies resulting from the upward directional solidification of Al – Ni alloys in a cylindrical crucible. We analysed the coupling of solid-liquid interface morphology with natural and forced convection. The influence of natural convection was first analyzed as a function of growth parameters (solute concentration, growth rate and thermal gradient). In a second step, the influence of axial vibrations on solidification microstructure was investigated by varying vibration parameters (amplitude and frequency). Experimental results were compared to preliminary numerical simulations and a good agreement is found for natural convection. In this study, the critical role of the mushy zone in the interaction between fluid flow and solidification microstructure is pointed out.
Published: 2006

9. Genome structures resolve the early diversification of teleost fishes

Author: Elise Parey, Alexandra Louis, Jerome Montfort, Olivier Bouchez, Céline Roques, Carole Iampietro, Jerome Lluch, Adrien Castinel, Cécile Donnadieu, Thomas Desvignes, Christabel Floi Bucao, Elodie Jouanno, Ming Wen, Sahar Mejri, Ron Dirks, Hans Jansen, Christiaan Henkel, Wei-Jen Chen, Margot Zahm, Cédric Cabau, Christophe Klopp, Andrew W. Thompson, Marc Robinson-Rechavi, Ingo Braasch, Guillaume Lecointre, Julien Bobe, John H. Postlethwait, Camille Berthelot, Hugues Roest Crollius, Yann Guiguen, Laboratoire de Physiologie et Génomique des Poissons (LPGP), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Institut de biologie de l'ENS Paris (IBENS), Département de Biologie - ENS Paris, École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Génome et Transcriptome - Plateforme Génomique ( GeT-PlaGe), Plateforme Génome & Transcriptome (GET), Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Ecole Nationale Vétérinaire de Toulouse (ENVT), Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Génopole Toulouse Midi-Pyrénées [Auzeville] (GENOTOUL), Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), University of Oregon [Eugene], Université de Lausanne = University of Lausanne (UNIL), Swiss Institute of Bioinformatics [Lausanne] (SIB), Hunan Normal University (HNU), Florida Atlantic University [Boca Raton], Future Genomics Technologies, Universiteit Leiden, Norwegian University of Life Sciences (NMBU), National Taiwan University [Taiwan] (NTU), Génétique Physiologie et Systèmes d'Elevage (GenPhySE ), Ecole Nationale Vétérinaire de Toulouse (ENVT), Université de Toulouse (UT)-Université de Toulouse (UT)-École nationale supérieure agronomique de Toulouse (ENSAT), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Système d'Information des GENomes des Animaux d'Elevage (SIGENAE), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Unité de Mathématiques et Informatique Appliquées de Toulouse (MIAT INRAE), Western Michigan University [Kalamazoo], Michigan State University [East Lansing], Michigan State University System, Institut de Systématique, Evolution, Biodiversité (ISYEB ), Muséum national d'Histoire naturelle (MNHN)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS)-Université des Antilles (UA), Génomique fonctionnelle comparative - Comparative functional genomics, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), This work was supported by the Agence Nationale de la Recherche, France (ANR) on the GenoFish project, 2016–2021 (grant No. ANR-16-CE12-003) to H.R.C., C.B., J.B., J.H.P., M.R.C., and Y.G., and by France Génomique National infrastructure, funded as part of 'Investissement d’avenir' program managed by ANR (grant No. ANR-10-INBS-09) to C.D. Part of the fellowship to E.P. was supported by funds from the European Union Horizon 2020 research and innovation program under Grant Agreement No 817923 (AQUA-FAANG). M.R.-R. was supported by the Swiss National Science Foundation grant 31003A_173048. J.H.P and I.B were supported by the National Institutes of Health under grant agreement No. R01OD011116. W.J.C. was supported by MOST grants No. 111-2611-M-002-025, 110-2611-M-002-013, and 108-2611-M-002-012-MY2., ANR-16-CE12-0035,GenoFish,Evolution des génes et des génomes après duplication compléte(2016), ANR-10-INBS-0009,France-Génomique,Organisation et montée en puissance d'une Infrastructure Nationale de Génomique(2010), European Project: 817923,H2020,H2020-EU.3.2.1.1., H2020-EU.3.2.3.1.,AQUA-FAANG(2019), DYnamique et Organisation des GENomes - Equipe de l'IBENS (DYOGEN), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Département de Biologie - ENS Paris, Institute of Oceanography [Taipei], Plateforme Bio-Informatique - Génotoul, Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Unité de Mathématiques et Informatique Appliquées de Toulouse (MIAT INRAE), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-BioInfOmics, Génétique des génomes - Genetics of Genomes (UMR 3525), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Swiss National Science Foundation grant 31003A_173048, National Institute of Health under grant agreement No R01OD011116, and Muséum national d'Histoire naturelle (MNHN)
Subjects: Animals, Zebrafish/genetics, Fishes/genetics, Eels/genetics, Biological Evolution, Phylogeny, Genome, Evolution, Molecular, Multidisciplinary, [SDV]Life Sciences [q-bio], [SDV.BA.ZV]Life Sciences [q-bio]/Animal biology/Vertebrate Zoology, [SDV.BID]Life Sciences [q-bio]/Biodiversity
Abstract: Accurate species phylogenies are a prerequisite for evolutionary research. Teleosts are by far the largest and the most diversified group of extant vertebrates, but relationships among the three oldest lineages of extant teleosts remain unresolved. Based on seven high-quality new genome assemblies in Elopomorpha (tarpons, eels), we revisited the topology of the deepest branches of the teleost phylogeny using independent gene sequence and chromosomal rearrangement phylogenomic approaches. These analyses converged to a single scenario that unambiguously places the Elopomorpha and Osteoglossomorpha (bony-tongues) in a monophyletic group sister to all other teleosts, i.e., the Clupeocephala lineage. This finding resolves over 50 years of controversy on the evolutionary relationships of these lineages and highlights the power of combining different levels of genome-wide information to solve complex phylogenies.One-Sentence SummaryWhole-genome analyses place Elopomorpha (tarpons, eels) and Osteoglossomorpha (bony-tongues) as sister groups at the deepest branching of crown teleosts.
Published: 2023

10. Processing of social and monetary rewards in autism spectrum disorders

Author: Baumeister, S., Moessnang, C., Bast, N., Hohmann, S., Aggensteiner, P., Kaiser, A., Tillmann, J., Goyard, D., Charman, T., Ambrosino, S., Baron-Cohen, S., Beckmann, C.F., Bölte, S., Bourgeron, T., Rausch, A., Crawley, D., Dell'Acqua, F., Dumas, G., Durston, S., Ecker, C., Floris, D.L., Frouin, V., Hayward, H., Holt, R., Johnson, M.H., Jones, E.J.H., Lai, M.C., Lombardo, M.V., Mason, L., Oakley, B., Oldehinkel, M., Persico, A.M., San José Cáceres, A., Wolfers, T., Loth, E., Murphy, D.G.M., Buitelaar, J.K., Tost, H., Meyer-Lindenberg, A., Banaschewski, T., Brandeis, D., Universität Heidelberg [Heidelberg] = Heidelberg University, Goethe-Universität Frankfurt am Main, King‘s College London, University of Vienna [Vienna], IFR49 - Neurospin - CEA, Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Utrecht University [Utrecht], University of Cambridge [UK] (CAM), Radboud University [Nijmegen], Radboud University Medical Center [Nijmegen], Karolinska Institutet [Stockholm], Stockholm Health Care Services (SLSO), The University of Western Australia (UWA), Génétique humaine et fonctions cognitives - Human Genetics and Cognitive Functions (GHFC (UMR_3571 / U-Pasteur_1)), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Universität Zürich [Zürich] = University of Zurich (UZH), University of London [London], University of Toronto, National Taiwan University [Taiwan] (NTU), Istituto Italiano di Tecnologia (IIT), Università degli Studi di Modena e Reggio Emilia = University of Modena and Reggio Emilia (UNIMORE), Centro de Investigación Biomédica en Red Salud Mental [Madrid] (CIBER-SAM), Karakter Child and Adolescent Psychiatry University Centre [Nijmegen], This work was supported by EU-AIMS (European Autism Interventions), which received support from the Innovative Medicines Initiative Joint Undertaking under grant agreement no. 115300, the resources of which are composed of financial contributions from the European Union’ s Seventh Framework Programme (grant FP7/2007-2013), from the European Federation of Pharmaceutical Industries and Associations companies’ in-kind contributions, and from Autism Speaks. The results leading to this publication have received funding from the Innovative Medicines Initiative 2 Joint Undertaking under grant agreement No 777394 for the project AIMS-2-TRIALS. This Joint Undertaking receives support from the European Union's Horizon 2020 research and innovation programme and EFPIA and AUTISM SPEAKS, Autistica, SFARI., European Project: 115300,EC:FP7:SP1-JTI,IMI-JU-03-2010,EU-AIMS(2012), and European Project: 777394,H2020-JTI-IMI2-2016-10-two-stage,AIMS-2-TRIALS(2018)
Subjects: Psychiatry and Mental health, All institutes and research themes of the Radboud University Medical Center, Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7], fMRI, multisite, Stress-related disorders Donders Center for Medical Neuroscience [Radboudumc 13], 220 Statistical Imaging Neuroscience, ADHD symptoms, Autism spectrum disorder, autism traits, reward processing, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC]
Abstract: BackgroundReward processing has been proposed to underpin the atypical social feature of autism spectrum disorder (ASD). However, previous neuroimaging studies have yielded inconsistent results regarding the specificity of atypicalities for social reward processing in ASD.AimsUtilising a large sample, we aimed to assess reward processing in response to reward type (social, monetary) and reward phase (anticipation, delivery) in ASD.MethodFunctional magnetic resonance imaging during social and monetary reward anticipation and delivery was performed in 212 individuals with ASD (7.6–30.6 years of age) and 181 typically developing participants (7.6–30.8 years of age).ResultsAcross social and monetary reward anticipation, whole-brain analyses showed hypoactivation of the right ventral striatum in participants with ASD compared with typically developing participants. Further, region of interest analysis across both reward types yielded ASD-related hypoactivation in both the left and right ventral striatum. Across delivery of social and monetary reward, hyperactivation of the ventral striatum in individuals with ASD did not survive correction for multiple comparisons. Dimensional analyses of autism and attention-deficit hyperactivity disorder (ADHD) scores were not significant. In categorical analyses, post hoc comparisons showed that ASD effects were most pronounced in participants with ASD without co-occurring ADHD.ConclusionsOur results do not support current theories linking atypical social interaction in ASD to specific alterations in social reward processing. Instead, they point towards a generalised hypoactivity of ventral striatum in ASD during anticipation of both social and monetary rewards. We suggest this indicates attenuated reward seeking in ASD independent of social content and that elevated ADHD symptoms may attenuate altered reward seeking in ASD.
Published: 2023

11. Genomic Surveillance of Listeria monocytogenes in Taiwan, 2014 to 2019

Author: Yu-Huan Tsai, Alexandra Moura, Zi-Qi Gu, Jui-Hsien Chang, Ying-Shu Liao, Ru-Hsiou Teng, Kuo-Yao Tseng, Dai-Ling Chang, Wei-Ren Liu, Yu-Tsung Huang, Alexandre Leclercq, Hsiu-Jung Lo, Marc Lecuit, Chien-Shun Chiou, National Yang Ming Chiao Tung University [Taipei] (NYCU), Biologie des Infections - Biology of Infection, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Centre National de Référence Listeria - National Reference Center Listeria (CNR), Centre collaborateur de l'OMS Listeria / WHO Collaborating Centre Listeria (CC-OMS / WHO-CC), Institut Pasteur [Paris] (IP)-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO)-Université Paris Cité (UPCité), Taiwan Centers for Disease Control, National Taiwan University [Taiwan] (NTU), National Health Research Institutes [Taiwan] (NHRI), China Medical University, Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), and This work was supported by Ministry of Health and Welfare, Taiwan (grant numbers DOH102-DC-2102 [2013], MOHW108-CDC-C-315-112520 [2019], MOHW109-CDC-C-315-122415 [2020]), Ministry of Science and Technology, Taiwan (grant number MOST 109-2320-B-010-039), National Health Research Institutes, Taiwan (grant number NHRI-EX111-11120SC), Institut Pasteur and Inserm.
Subjects: Microbiology (medical), General Immunology and Microbiology, Ecology, Physiology, [SDV]Life Sciences [q-bio], Cell Biology, Listeria monocytogenes, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, Infectious Diseases, [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology, listeriosis, whole-genome sequencing, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Genetics, core genome multilocus sequence typing, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract: International audience; Listeria monocytogenes is a life-threatening foodborne pathogen. Here, we report the genomic characterization of a nationwide dataset of 411 clinical and 82 food isolates collected in Taiwan between 2014 and 2019. The observed incidence of listeriosis increased from 0.83 to 7 cases per million population upon implementation of mandatory notification in 2018. Pregnancy-associated cases accounted for 2.8% of human listeriosis and all-cause 7-day mortality was of 11.9% in nonmaternal-neonatal listeriosis. L. monocytogenes was isolated from 90% of raw pork and 34% of chicken products collected in supermarkets. Sublineages SL87, SL5, and SL378 accounted for the majority (65%) of clinical cases. SL87 and SL378 were also predominant (57%) in food products. Five cgMLST clusters accounted for 57% clinical cases, suggesting unnoticed outbreaks spanning up to 6 years. Mandatory notification allowed identifying the magnitude of listeriosis in Taiwan. Continuous real-time genomic surveillance will allow reducing contaminating sources and disease burden.
Published: 2022

12. Hotspots of Cenozoic Tropical Marine Biodiversity

Author: Moriaki Yasuhara, Huai-Hsuan May Huang, Markus Reuter, Skye Yunshu Tian, Jonathan D. Cybulski, Aaron O’Dea, Briony L. Mamo, Laura J. Cotton, Emanuela Di Martino, Ran Feng, Clay R. Tabor, Gabriel Reygondeau, Qianshuo Zhao, Mark T. Warne, Kyawt K. T. Aye, Jingwen Zhang, Anne Chao, Chih-Lin Wei, Fabien L. Condamine, Adam T. Kocsis, Wolfgang Kiessling, Mark J. Costello, Derek P. Tittensor., Chhaya Chaudhary, Marina C. Rillo, Hideyuki Doi, Yun-wei Dong, Thomas M. Cronin, Erin E. Saupe, Heike K. Lotze, Kenneth G. Johnson, Willem Renema, John M. Pandolfi, Mathias Harzhauser, Jeremy B. C. Jackson, Yuanyuan Hong, School of biological sciences (Hong Kong, Chine), The University of Hong Kong (HKU), Smithsonian Institution, Universität Greifswald - University of Greifswald, Smithsonian Tropical Research Institute, University of Bologna/Università di Bologna, Macquarie University, Natural History Museum of Denmark, Faculty of Science [Copenhagen], University of Copenhagen = Københavns Universitet (UCPH)-University of Copenhagen = Københavns Universitet (UCPH), University of Oslo (UiO), University of Connecticut (UCONN), University of British Columbia (UBC), Ocean University of China (OUC), Deakin University [Burwood], National Tsing Hua University [Hsinchu] (NTHU), National Taiwan University [Taiwan] (NTU), Institut des Sciences de l'Evolution de Montpellier (UMR ISEM), Centre de Coopération Internationale en Recherche Agronomique pour le Développement (Cirad)-École Pratique des Hautes Études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Institut de recherche pour le développement [IRD] : UR226-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), MTA-MTM-ELTE Research Group for Paleontology, Eötvös Loránd University (ELTE)-Hungarian Academy of Sciences (MTA), Faculty of Biosciences and Aquaculture [Bodø], University of Nordland, Dalhousie University [Halifax], United Nations Environment Programme (UNEP) World Conservation Monitoring Center (WCMC) (UNEP WCMC), Alfred Wegener Institute [Potsdam], Alfred-Wegener-Institut, Helmholtz-Zentrum für Polar- und Meeresforschung (AWI), Carl Von Ossietzky Universität Oldenburg = Carl von Ossietzky University of Oldenburg (OFFIS), Center for Marine Environmental Sciences [Bremen] (MARUM), Universität Bremen, University of Hyogo, Qingdao National Laboratory for Marine Science and Technology, US Geological Survey [Salt Lake City], United States Geological Survey [Reston] (USGS), University of Oxford, The Natural History Museum [London] (NHM), Naturalis Biodiversity Center [Leiden], Institute for Biodiversity and Ecosystem Dynamics (IBED), University of Amsterdam [Amsterdam] (UvA), University of Queensland [Brisbane], Natural History Museum [Vienna] (NHM), American Museum of Natural History (AMNH), Nanjing Institute of Geology and Palaeontology (NIGPAS-CAS), Chinese Academy of Sciences [Nanjing Branch], This work is a product of the PSEEDS (Palaeobiology as the Synthetic Ecological, Evolutionary, and Diversity Sciences) project and is partly supported by grants from the Research Grants Council of the Hong Kong Special Administrative Region, China (project codes: HKU 17300821, HKU 17300720, HKU 17302518, C7050-18E, C7013-19G), the Marine Conservation Enhancement Fund (project code: MCEF20002_L01), the Marine Ecology Enhancement Fund (project code: MEEF2021001), the Small Equipment Grant of the University of Hong Kong, the Seed Funding Programme for Basic Research of the University of Hong Kong (project codes: 202011159122, 201811159076), the Faculty of Science RAE Improvement Fund of the University of Hong Kong, the Seed Funding of the HKU-TCL Joint Research Centre for Artificial Intelligence of the University of Hong Kong and the SKLMP Seed Collaborative Research Fund (SKLMP/SCRF/0031) (to M.Y.), by the Sistema Nacional de Investigadores (SENACYT) (to A.O), by the Australian Research Council Centre of Excellence for Coral Reef Studies (to J.M.P.), by the Austrian Science Fund (FWF, project code: P 29158-N29) (to M.R.), and by State Key Laboratory of Palaeobiology and Stratigraphy and Nanjing Institute of Geology and Palaeontology, Chinese Academy of Sciences (project code: 203108) (to Y.H.)., Stephen J. Hawkins, A. Louise Allcock, Peter A. Todd, Stephen E. Swearer‬, Maria Byrne, Louise B. Firth, Anaëlle J. Lemasson, Cathy H. Lucas, Ezequiel M. Marzinelli, Peter J. Mumby, Bayden D. Russell, I. Philip Smith, and Hawkins, S. J.
Subjects: Species diversity gradients, Global patterns, [SDV]Life Sciences [q-bio], Tropics, Neogene, Paleobiology, Fossil records, Paleogene
Abstract: International audience; Hotspots of tropical marine biodiversity are areas that harbour disproportionately large numbers of species compared to surrounding regions. The richness and location of these hotspots have changed throughout the Cenozoic. Here, we review the global dynamics of Cenozoic tropical marine biodiversity hotspots, including the four major hotspots of the Indo-Australian Archipelago (IAA), western Tethys (present Mediterranean), Arabian Sea and Caribbean Sea. Our review supports the ‘Hopping Hotspots’ model, which proposes that the locations of peak biodiversity are related to Tethyan faunal elements and track broad-scale shallow-marine habitats and high coastal complexity created by the collision of tectonic plates. A null hypothesis is the ‘Whack-A-Mole’ model, which proposes that hotspots occur in habitats suitable for high diversity regardless of taxonomic identity or faunal elements. Earlier ‘Centre-of’ theories (e.g. centres of origin with diversity decreasing with distance from supposed areas of exceptionally high rates of speciation, for which easy connection to adjacent regions to the east and west is important) were based on the analysis of recent biotas with no palaeontological foundation, and may better explain diversity dynamics within a hotspot rather than those between hotspots. More recently, however, human disturbance is massively disrupting these natural patterns.
Published: 2022

13. Tracking westerly wind directions over Europe since the middle Holocene

Author: Hsun-Ming Hu, Valerie Trouet, Christoph Spötl, Hsien-Chen Tsai, Wei-Yi Chien, Wen-Hui Sung, Véronique Michel, Jin-Yi Yu, Patricia Valensi, Xiuyang Jiang, Fucai Duan, Yongjin Wang, Horng-Sheng Mii, Yu-Min Chou, Mahjoor Ahmad Lone, Chung-Che Wu, Elisabetta Starnini, Marta Zunino, Takaaki K. Watanabe, Tsuyoshi Watanabe, Huang-Hsiung Hsu, G.W.K. Moore, Giovanni Zanchetta, Carlos Pérez-Mejías, Shih-Yu Lee, Chuan-Chou Shen, High-Precision Mass Spectrometry and Environment Change Laboratory (HISPEC), National Taiwan University [Taiwan] (NTU), Research Center for Future Earth, National Taiwan University, Taipei, Laboratory of Tree-Ring Research [University of Arizona] (LTRR), University of Arizona, Institute of Geology, University of Innsbruck, Culture et Environnements, Préhistoire, Antiquité, Moyen-Age (CEPAM), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Géoazur (GEOAZUR 7329), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Department of Earth System Science, University of California, Irvine, Histoire naturelle de l'Homme préhistorique (HNHP), Muséum national d'Histoire naturelle (MNHN)-Université de Perpignan Via Domitia (UPVD)-Centre National de la Recherche Scientifique (CNRS), Institut de Paléontologie Humaine (IPH), Fondation I.P.H-Centre National de la Recherche Scientifique (CNRS), Department of Geography Science, Fujian Normal University, College of Geography Science, Nanjing Normal University, Department of Earth Sciences, National Taiwan Normal University, Taipei, Department of Ocean Science & Engineering, Southern University of Science and Technology, Department of Geography and Environmental Sciences, Northumbria University, Newcastle, Department of Civilizations and Forms of Knowledge, University of Pisa, Archaeological Superintendency of Liguria, Toirano Cave, 17055, Toirano, Department of Natural History Sciences, Faculty of Science, Hokkaido University, Research Center for Environmental Changes, Academia Sinica, Taipei, Department of Physics, University of Toronto, Department of Chemical and Physical Sciences, University of Toronto Mississauga, Department of Earth Sciences, University of Pisa, Istituto Nazionale di Geofisica e Vulcanologia – Sezione di Pisa (INGV), Istituto Nazionale di Geofisica e Vulcanologia, IGAG-CNR, Area della Ricerca di Roma RM1, and Institute of Global Environmental Change, Xi’an Jiaotong University
Subjects: Multidisciplinary, Climate, General Physics and Astronomy, [SDU.STU]Sciences of the Universe [physics]/Earth Sciences, Wind, General Chemistry, General Biochemistry, Genetics and Molecular Biology, [SHS]Humanities and Social Sciences, Europe, Italy, [SDE]Environmental Sciences, Hydrology, Atlantic Ocean, Climate sciences
Abstract: The variability of the northern westerlies has been considered as one of the key elements for modern and past climate evolution. Their multiscale behavior and underlying control mechanisms, however, are incompletely understood, owing to the complex dynamics of Atlantic sea-level pressures. Here, we present a multi-annually resolved record of the westerly drift over the past 6,500 years from northern Italy. In combination with more than 20 other westerly-sensitive records, our results depict the non-stationary westerly-affected regions over mainland Europe on multi-decadal to multi-centennial time scales, showing that the direction of the westerlies has changed with respect to the migrations of the North Atlantic centers of action since the middle Holocene. Our findings suggest the crucial role of the migrations of the North Atlantic dipole in modulating the westerly-affected domain over Europe, possibly modulated by Atlantic Ocean variability.
Published: 2022

14. Lack of replication of the GRIN2A-by-coffee interaction in Parkinson disease

Author: Sebastian M. Armasu, Tian Liu, Johnni Hansen, Beate Ritz, Harvey Checkoway, Marie-Anne Loriot, Susan Searles Nielsen, Ismaïl Ahmed, Alexis Elbaz, Magali Nacfer, Joanna M. Biernacka, Christina Funch Lassen, Jørgen H. Olsen, Lisa G. Gallagher, Pei-Chen Lee, Claire Mulot, Kari J. Anderson, Demetrius M. Maraganore, Fanny Artaud, Lars Bertram, Federico M. Farin, Christina M. Lill, Laboratoire brestois de mécanique et des systèmes (LBMS), École Nationale d'Ingénieurs de Brest (ENIB)-Université de Brest (UBO)-École Nationale Supérieure de Techniques Avancées Bretagne (ENSTA Bretagne), Centre de recherche en épidémiologie et santé des populations (CESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris-Sud - Paris 11 (UP11)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), National Taiwan University [Taiwan] (NTU), Max Planck Institute for Molecular Genetics (MPIMG), Max-Planck-Gesellschaft, Focus Program Translational Neuroscienc, Universitätsmedizin der Johannes Gutenberg-Universität Mainz, Department of Environmental and Occupational Health Sciences, University of Washington [Seattle], Department of Psychiatry, Trinity College Dublin-St. James's Hospital, Bases moléculaires de la réponse aux xénobiotiques (U775 (IFR95)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Epigenetec, Centre de Ressources Biologiques (CRB), Institut des Sciences Moléculaires (ISM), Université Montesquieu - Bordeaux 4-Université Sciences et Technologies - Bordeaux 1-École Nationale Supérieure de Chimie et de Physique de Bordeaux (ENSCPB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), Mayo Clinic, Department of Health Sciences Research, Danish Cancer Society, Institute of Cancer Biology, Department of Neurology, Mayo Clinic College of Medicine, Department of Epidemiology, University of California [Los Angeles] (UCLA), University of California-University of California, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), Université Montesquieu - Bordeaux 4-Université Sciences et Technologies - Bordeaux 1 (UB)-École Nationale Supérieure de Chimie et de Physique de Bordeaux (ENSCPB)-Institut de Chimie du CNRS (INC)-Centre National de la Recherche Scientifique (CNRS), University of California (UC)-University of California (UC), SZTAJNBOK, Pascale, Laboratoire brestois de mécanique et des systèmes ( LBMS ), École Nationale d'Ingénieurs de Brest ( ENIB ) -Université de Brest ( UBO ) -ENSTA Bretagne, Centre de recherche en épidémiologie et santé des populations ( CESP ), Université de Versailles Saint-Quentin-en-Yvelines ( UVSQ ) -Université Paris-Sud - Paris 11 ( UP11 ) -Assistance publique - Hôpitaux de Paris (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale ( INSERM ), National Taiwan University [Taiwan] ( NTU ), Max Planck Institute for Molecular Genetics, Max-Planck-Institut, Bases moléculaires de la réponse aux xénobiotiques ( U775 (IFR95) ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Centre National de la Recherche Scientifique ( CNRS ), Institut des Sciences Moléculaires ( ISM ), Université Montesquieu - Bordeaux 4-Université Sciences et Technologies - Bordeaux 1-École Nationale Supérieure de Chimie et de Physique de Bordeaux (ENSCPB)-Centre National de la Recherche Scientifique ( CNRS ), and University of California at Los Angeles [Los Angeles] ( UCLA )
Subjects: Cancer Research, lcsh:QH426-470, Genome-wide association study, Single-nucleotide polymorphism, Disease, Coffee, Receptors, N-Methyl-D-Aspartate, Formal Comment, 03 medical and health sciences, 0302 clinical medicine, Genetics, Genetic predisposition, Humans, SNP, Allele, Molecular Biology, Genetics (clinical), Ecology, Evolution, Behavior and Systematics, 030304 developmental biology, 0303 health sciences, biology, [ SDV.SPEE ] Life Sciences [q-bio]/Santé publique et épidémiologie, Parkinson Disease, Replicate, 3. Good health, lcsh:Genetics, [SDV.SPEE] Life Sciences [q-bio]/Santé publique et épidémiologie, biology.protein, GRIN2A, Gene-Environment Interaction, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, 030217 neurology & neurosurgery, Genome-Wide Association Study, Demography
Abstract: International audience; Overview The etiology of Parkinson disease (PD) involves both genetic susceptibility and environmental exposures. In particular, coffee consumption is inversely associated with PD but the mechanisms underlying this intriguing association are unknown. According to a recent genome-wide gene–environment interaction study, the inverse coffee–PD association was two times stronger among carriers of the T allele of SNP rs4998386 in gene GRIN2A than in homozygotes for the C allele. We attempted to replicate this result in a similarly sized pooled analysis of 2,289 cases and 2,809 controls from four independent studies (Denmark, France, Seattle-United States (US), and Rochester-US) with detailed caffeinated coffee consumption data and rs4998386 genotypes. Using a variety of definitions of coffee drinking and statistical modeling techniques , we failed to replicate this interaction. Notably, whereas in the original study there was an association between rs4998386 and coffee consumption among controls, but not among cases, none of the datasets analyzed here indicated an association between rs4998386 and coffee consumption among controls. Based on large, well-characterized datasets independent from the original study, our results are not in favor of an interaction between caffeinated coffee consumption and rs4998386 for PD risk and suggest that the original finding may have been driven by an association of coffee consumption with rs4998386 in controls. The next years will likely see an increasing number of papers examining gene–environment interactions at the genome-wide level, which poses important methodological challenges. Our findings underline the need for a careful assessment of the findings of such studies.
Published: 2014

15. Combining experimental and theoretical methods to learn about the reactivity of gas-processing metalloenzymes

Author: Claudio Greco, Vincent Fourmond, Po-hung Wang, Sébastien Dementin, Carole Baffert, Maurizio Bruschi, Patrick Bertrand, Luca De Gioia, Christophe Léger, Jochen Blumberger, Department of Earth and Environmental Sciences, Università degli Studi di Milano-Bicocca [Milano], Institut de Microbiologie de la Méditerranée ( IMM ), Aix Marseille Université ( AMU ) -Centre National de la Recherche Scientifique ( CNRS ), Institute of Oceanography [Taipei], National Taiwan University [Taiwan] ( NTU ), Dipartimento di Biotecnologie e Bioscienze, Department of Physics and Astronomy [UCL London], University College of London [London] ( UCL ), Department of Earth and Environmental Sciences [Milano], Università degli Studi di Milano-Bicocca [Milano] (UNIMIB), Institut de Microbiologie de la Méditerranée (IMM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), National Taiwan University [Taiwan] (NTU), University College of London [London] (UCL), Università degli Studi di Milano-Bicocca = University of Milano-Bicocca (UNIMIB), Greco, C, Fourmond, V, Baffert, C, Wang, P, Dementin, S, Bertrand, P, Bruschi, M, Blumberger, J, DE GIOIA, L, and Léger, C
Subjects: enzymes, Context (language use), [CHIM.INOR]Chemical Sciences/Inorganic chemistry, DFT, theoretical chemistry, bioinorganic chemistry, Molecular level, catalytic power of enzymes, computational chemistry, spectroscopy, Computational chemistry, Theoretical chemistry, Environmental Chemistry, Reactivity (chemistry), [SDV.BBM]Life Sciences [q-bio]/Biochemistry, Molecular Biology, [ SDV.BBM ] Life Sciences [q-bio]/Biochemistry, Molecular Biology, Renewable Energy, Sustainability and the Environment, Chemistry, [ CHIM.INOR ] Chemical Sciences/Inorganic chemistry, Pollution, [CHIM.THEO]Chemical Sciences/Theoretical and/or physical chemistry, QMMM, Nuclear Energy and Engineering, electrochemistry, Protein film voltammetry, Theoretical methods, [ CHIM.THEO ] Chemical Sciences/Theoretical and/or physical chemistry, Physical chemistry, Experimental methods
Abstract: International audience; After enzymes were first discovered in the late XIX century, and for the first seventy years of enzymology, kinetic experiments were the only source of information about enzyme mechanisms. Over the following fifty years, these studies were taken over by approaches that give information at the molecular level, such as crystallography, spectroscopy and theoretical chemistry (as emphasized by the Nobel Prize in Chemistry awarded last year to M. Karplus, M. Levitt and A. Warshel). In this review, we thoroughly discuss the interplay between the information obtained from theoretical and experimental methods, by focussing on enzymes that process small molecules such as H 2 or CO 2 (hydrogenases, CO-dehydrogenase and carbonic anhydrase), and that are therefore relevant in the context of energy and environment. We argue that combining theoretical chemistry (DFT, MD, QM/MM) and detailed investigations that make use of modern kinetic methods, such as protein film voltammetry, is an innovative way of learning about individual steps and/or complex reactions that are part of the catalytic cycles. We illustrate this with recent results from our labs and others, including studies of gas transport along substrate channels, long range proton transfer, and mechanisms of catalysis, inhibition or inactivation. Broader context Some reactions which are very important in the context of energy and environment, such as the conversion between CO and CO2 , or H+ and H2 , are catalyzed in living organisms by large and complex enzymes that use inorganic active sites to transform substrates, chains of redox centers to transfer electrons, ionizable amino acids to transfer protons, and networks of hydrophobic cavities to guide the diffusion of substrates and products within the protein. This highly sophisticated biological plumbing and wiring makes turnover frequencies of thousands of substrate molecules per second possible. Understanding the molecular details of catalysis is still a challenge. We explain in this review how a great deal of information can be obtained using an interdisciplinary approach that combines state-of-the art kinetics and computational chemistry. This differs from—and complements—the more traditional strategies that consist in trying to see the catalytic intermediates using methods that rely on the interaction between light and matter, such as X-ray diffraction and spectroscopic techniques.
Published: 2014

16. Methane line parameters in the HITRAN2012 database

Author: Laurence S. Rothman, O.M. Lyulin, L. Wang, Hiroyuki Sasada, Ch. Wenger, Tony Gabard, James J. O'Brien, Michael Rey, Alain Campargue, Samir Kassi, Keeyoon Sung, Iouli E. Gordon, Arlan W. Mantz, L. Régalia, Ludovic Daumont, Vincent Boudon, Linda R. Brown, Tucker Carrington, Sigurd Bauerecker, O. Leshchishina, Sieghard Albert, Athena Coustenis, Andrei Nikitin, D. C. Benner, V. M. Devi, X. Thomas, Mary Ann H. Smith, Xiao-Gang Wang, P. T. Spickler, Vl.G. Tyuterev, Didier Mondelain, Martin Quack, Hans-Martin Niederer, Jet Propulsion Laboratory (JPL), NASA-California Institute of Technology (CALTECH), Department of Physics, The College of William and Mary, College of William and Mary [Williamsburg] (WM), Laboratoire Interdisciplinaire Carnot de Bourgogne (LICB), Université de Bourgogne (UB)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Interdisciplinaire de Physique [Saint Martin d’Hères] (LIPhy), Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), Groupe de spectrométrie moléculaire et atmosphérique (GSMA), Université de Reims Champagne-Ardenne (URCA)-Centre National de la Recherche Scientifique (CNRS), Laboratorium für Physikalische Chemie (ETH-LPC), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Department of Chemistry and Biochemistry, University of Missouri, University of Missouri [Columbia] (Mizzou), University of Missouri System-University of Missouri System, Harvard-Smithsonian Center for Astrophysics (CfA), Harvard University [Cambridge]-Smithsonian Institution, Department of Physics, Faculty of Science and Technology, Keio University, Laboratoire d'études spatiales et d'instrumentation en astrophysique (LESIA), Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), LRC Science Directorate, NASA Langley Research Center [Hampton] (LaRC), Chemistry Department, Queen's University, Queen's University [Kingston, Canada], Department of Physics, Astronomy and Geophysics [New London], Connecticut College, Department of Physics, Bridgewater College, Bridgewater College, Jet Propulsion Laboratory ( JPL ), NASA-California Institute of Technology ( CALTECH ), Laboratoire de Spectronomie Moléculaire ( SMIL ), Université de Bourgogne ( UB ), LIPhy-LAME, Laboratoire Interdisciplinaire de Physique [Saint Martin d’Hères] ( LIPhy ), Université Joseph Fourier - Grenoble 1 ( UJF ) -Centre National de la Recherche Scientifique ( CNRS ) -Université Joseph Fourier - Grenoble 1 ( UJF ) -Centre National de la Recherche Scientifique ( CNRS ), Center for Condensed Matter Sciences Taipei, National Taiwan University [Taiwan] ( NTU ), Groupe de spectrométrie moléculaire et atmosphérique - UMR 7331 ( GSMA ), Université de Reims Champagne-Ardenne ( URCA ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratorium für Physikalische Chemie ( ETH-LPC ), Eidgenössische Technische Hochschule [Zürich] ( ETH Zürich ), Mesoscale Air-Sea Interaction Group, Florida State University [Tallahassee] ( FSU ), Atomic and Molecular Physics Division ( AMPD ), Harvard-Smithsonian Center for Astrophysics, Laboratoire de Spectronomie Moléculaire (SMIL), Université de Bourgogne (UB), LAsers, Molécules et Environnement (LAME-LIPhy), Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Centre National de la Recherche Scientifique (CNRS), National Taiwan University [Taiwan] (NTU), Florida State University [Tallahassee] (FSU), Atomic and Molecular Physics Division [Cambridge] (AMP), Harvard University [Cambridge]-Smithsonian Institution-Harvard University [Cambridge]-Smithsonian Institution, Laboratoire Interdisciplinaire Carnot de Bourgogne (ICB), Harvard University-Smithsonian Institution, California Institute of Technology ( CALTECH ) -NASA, The College of William and Mary, Laboratoire Interdisciplinaire Carnot de Bourgogne ( LICB ), Université de Bourgogne ( UB ) -Centre National de la Recherche Scientifique ( CNRS ), Université Joseph Fourier - Grenoble 1 ( UJF ) -Centre National de la Recherche Scientifique ( CNRS ), UNIVERSITY OF MISSOURI, Harvard-Smithsonian Center for Astrophysics ( CfA ), Keio University, Laboratoire d'études spatiales et d'instrumentation en astrophysique ( LESIA ), Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut national des sciences de l'Univers ( INSU - CNRS ) -Observatoire de Paris-Université Paris Diderot - Paris 7 ( UPD7 ) -Centre National de la Recherche Scientifique ( CNRS ), NASA Langley Research Center [Hampton] ( LaRC ), Queen's University [Kingston], and Department of Physics, Astronomy and Geophysics, Connecticut College
Subjects: Materials science, 010504 meteorology & atmospheric sciences, Planets, computer.software_genre, 01 natural sciences, Spectral line, Methane, Cavity ring-down spectroscopy, 010309 optics, chemistry.chemical_compound, Line parameters, 0103 physical sciences, Isotopologue, Spectroscopy, 0105 earth and related environmental sciences, Line (formation), [PHYS.PHYS.PHYS-OPTICS]Physics [physics]/Physics [physics]/Optics [physics.optics], [ PHYS.PHYS.PHYS-OPTICS ] Physics [physics]/Physics [physics]/Optics [physics.optics], Radiation, Database, Differential optical absorption spectroscopy, Exoplanets, Remote sensing, Atomic and Molecular Physics, and Optics, chemistry, HITRAN database, Atomic physics, Ground state, computer, Microwave
Abstract: International audience; The compilation of methane molecular line parameters was updated to include new global analyses and measurements for 12CH4, 13CH4 and 12CH3D. Over 70% of the methane parameters in HITRAN2008 were replaced; existing parameters retained were the microwave lines and the Dyad of 13CH4 near 7 μm and ν6 of 13CH3D near 8.7 μm, 12CH3D (7-4076 cm-1), hot bands of 12CH4 (1887-3370 cm-1) and normal sample CH4 (4800-5550 cm-1 and 8000-9200 cm-1). With a minimum intensity at 296 K in units of cm-1/(molecule cm-2) set to 10-37 for the far-IR and 10-29 for the mid- and near-IR, the methane database increased from 290,091 lines in HITRAN2008 to 468,013 lines, and three-fourths of these involved the main isotopologue. For 12CH4 and 13CH4, bands from the ground state were revised up to 4800 cm-1. For the first time, 13CH4 and 12CH3D line parameters near 2.3 μm were included. Above 5550 cm-1, the new compilation was based on empirical measurements. Prior laboratory results were replaced with extensive new measurements using FTIR (5550-5852 cm-1), differential absorption spectroscopy (DAS) and Cavity Ring Down Spectroscopy (CRDS) (5852-7912 cm-1). Ground state J values for nearly half of the measured lines in this range were obtained, either by confirming quantum assignments of analyses or by using spectra at 80 and 296 K. Finally, over 11,000 measured positions, intensities and empirical lower state energies (obtained using cold CH4) were also added for the first time between 10,923 and 11,502 cm-1. Available pressure broadening measurements from HITRAN2008 were transferred into the new compilation, but 99% of the lines were given crudely-estimated coefficients. New measured intensities and broadening coefficients were included for far-IR transitions, and high accuracy line positions were inserted for the stronger P, Q and R branch transitions of v3 at 3.3 μm and 2v3 at 1.66 μm.
Published: 2013
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17. Optimistic Heuristics for MineSweeper

Author: Chang-Shing Lee, Olivier Teytuad, Woan-Tyng Lin, Olivier Buffet, Autonomous intelligent machine (MAIA), Inria Nancy - Grand Est, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Department of Complex Systems, Artificial Intelligence & Robotics (LORIA - AIS), Laboratoire Lorrain de Recherche en Informatique et ses Applications (LORIA), Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)-Institut National de Recherche en Informatique et en Automatique (Inria)-Laboratoire Lorrain de Recherche en Informatique et ses Applications (LORIA), Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL), OASE, Institute of Computer Science and Information Engineering [Taiwan] (Institute of CSIE), National Taiwan University [Taiwan] (NTU)-National Taiwan University [Taiwan] (NTU), National University of Tainan (NUTN), National Taiwan University [Taiwan] (NTU), Machine Learning and Optimisation (TAO), Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Université Paris-Sud - Paris 11 (UP11)-Laboratoire de Recherche en Informatique (LRI), Université Paris-Sud - Paris 11 (UP11)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-CentraleSupélec, Laboratoire de Recherche en Informatique (LRI), Université Paris-Sud - Paris 11 (UP11)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS), Department of Electrical Engineering and Computer Science (Institut Montefiore), Université de Liège, Ruay-Shiung Chang and Lakhmi C. Jain and Sheng-Lung Peng, indema, Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Laboratoire Lorrain de Recherche en Informatique et ses Applications (LORIA), Institut National de Recherche en Informatique et en Automatique (Inria)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS)-Université de Lorraine (UL)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, and Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)
Subjects: Theoretical computer science, business.industry, Computer science, 05 social sciences, 050301 education, 02 engineering and technology, Term (time), Domain (software engineering), Tree (data structure), 0202 electrical engineering, electronic engineering, information engineering, 020201 artificial intelligence & image processing, [MATH.MATH-OC]Mathematics [math]/Optimization and Control [math.OC], Artificial intelligence, State (computer science), business, Heuristics, 0503 education, Constraint satisfaction problem
Abstract: International audience; We present a combination of Upper Con dence Tree (UCT) and domain speci c solvers, aimed at improving the behavior of UCT for long term aspects of a problem. Results improve the state of the art, combining top performance on small boards (where UCT is the state of the art) and on big boards (where variants of CSP rule).
Published: 2013

18. Gymnocranius superciliosus and Gymnocranius satoi, two new large-eye breams (Sparoidea: Lethrinidae) from the Coral Sea and adjacent regions

Author: Wei-Jen Chen, Sobar Paijo, Philippe Béarez, Philippe Borsa, Biocomplexité des écosystèmes coralliens de l'Indo-Pacifique (CoReUS2), Archéozoologie, archéobotanique : sociétés, pratiques et environnements (AASPE), Muséum national d'Histoire naturelle (MNHN)-Centre National de la Recherche Scientifique (CNRS), Proyek BarKor, BarKor, private consultant-private consultant, Inst. Oceanogr. National Taiwan University, Oceanography Institute, and National Taiwan University [Taiwan] (NTU)-National Taiwan University [Taiwan] (NTU)
Subjects: 0106 biological sciences, Subfamily, Population, Cytochrome b, Gymnocranius satoi, Color, Eye, 010603 evolutionary biology, 01 natural sciences, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Species Specificity, New Caledonia, Coral sea, Terminology as Topic, Animals, 14. Life underwater, Lethrinidae, Torao Sato, Ecosystem, 030304 developmental biology, 0303 health sciences, Pacific Ocean, [SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE], General Immunology and Microbiology, biology, Base Sequence, Ecology, Fish fin, General Medicine, Anatomy, DNA, Cytochromes b, biology.organism_classification, Gymnocranius, Monotaxinae, Sea Bream, Haplotypes, cytochrome b, Gymnocranius sp, General Agricultural and Biological Sciences, Snout
Abstract: International audience; Two related perciform fish species of the subfamily Monotaxinae (Sparoidea: Lethrinidae) Gymnocranius superciliosus sp. nov. and Gymnocranius satoi sp. nov. are described from specimens and tissue samples from the Coral Sea and adjacent regions. Gymnocranius superciliosus sp. nov. is distinct from all other known Gymnocranius spp. by the following combination of characters: body elongated (depth 2.7-3.1 in standard length), caudal fin moderately forked with a subtle middle notch, its lobes slightly convex inside, distinctive blackish eyebrow, snout and cheek with blue speckles, and dorsal, pectoral, anal and caudal fins reddish. Gymnocranius satoi sp. nov. is the red-finned 'Gymnocranius sp.' depicted in previous taxonomic revisions. While colour patterns are similar between the two species, Gymnocranius satoi sp. nov. is distinct from Gymnocranius superciliosus sp. nov. by the ratio of standard length to body depth (2.4-2.5 vs. 2.7-3.1) and by the shape of the caudal fin, which is more shallowly forked, its lobes convex inside and their extremities rounded. The two species are genetically distinct from each other and they are genetically distinct from G. elongatus, G. euanus, G. grandoculis, and G. oblongus sampled from the Coral Sea and adjacent regions.
Published: 2013

19. Fuzzy Ontologies for the Game of Go

Author: Mei-Hui Wang, Olivier Teytaud, Chang-Shing Lee, OASE, Institute of Computer Science and Information Engineering [Taiwan] (Institute of CSIE), National Taiwan University [Taiwan] (NTU)-National Taiwan University [Taiwan] (NTU), National University of Tainan (NUTN), National Taiwan University [Taiwan] (NTU), Machine Learning and Optimisation (TAO), Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Université Paris-Sud - Paris 11 (UP11)-Laboratoire de Recherche en Informatique (LRI), Université Paris-Sud - Paris 11 (UP11)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-CentraleSupélec, Laboratoire de Recherche en Informatique (LRI), Université Paris-Sud - Paris 11 (UP11)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS), R. Seising, E. Trillas, C. Moraga, S. Termini, Université Paris-Sud - Paris 11 (UP11)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, and Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)
Subjects: 060201 languages & linguistics, Computer science, business.industry, Ontology-based data integration, Process ontology, ComputingMilieux_PERSONALCOMPUTING, Suggested Upper Merged Ontology, 06 humanities and the arts, 02 engineering and technology, Ontology (information science), Domain (software engineering), 0602 languages and literature, 0202 electrical engineering, electronic engineering, information engineering, Domain knowledge, Upper ontology, 020201 artificial intelligence & image processing, [MATH.MATH-OC]Mathematics [math]/Optimization and Control [math.OC], ComputingMethodologies_GENERAL, Artificial intelligence, business, Computer Go
Abstract: International audience; Abstract This chapter presents a developed fuzzy ontology model for computer Go applica- tions. Unlike previous research, this chapter employs features derived from professional Go players' domain knowledge to transform them into the opening book sequence and to repre- sent them by a fuzzy ontology for the game of Go. Afterward, the domain experts validate the built fuzzy ontology. The developed fuzzy ontology has been verified through the invited games for Go programs playing against human Go players. The results show that the fuzzy ontology can work for computer Go application.
Published: 2013

20. Resurrection of New Caledonian maskray Neotrygon trigonoides (Myliobatoidei: Dasyatidae) from synonymy with N. kuhlii, based on cytochrome-oxidase I gene sequences and spotting patterns

Author: Kang-Ning Shen, Jean-Dominique Durand, Mark G. Meekan, Wei-Jen Chen, Philippe Borsa, Irma S. Arlyza, Biocomplexité des écosystèmes coralliens de l'Indo-Pacifique (CoReUS2), Pusat Penelitian Oseanografi (P2O), LIPI, Inst. Oceanogr. National Taiwan University, Oceanography Institute, National Taiwan University [Taiwan] (NTU)-National Taiwan University [Taiwan] (NTU), Ecologie des systèmes marins côtiers (Ecosym), Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Australian Institute of Marine Science [Perth] (AIMS Perth), Australian Institute of Marine Science (AIMS), Institute of Fisheries Science, National Taiwan University [Taiwan] (NTU), and Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Centre National de la Recherche Scientifique (CNRS)
Subjects: 0106 biological sciences, Zoology, Color, 010603 evolutionary biology, 01 natural sciences, Polymerase Chain Reaction, General Biochemistry, Genetics and Molecular Biology, Haplogroup, Coral Triangle, 03 medical and health sciences, New Caledonia, Terminology as Topic, Animals, 14. Life underwater, Skates, Fish, Reef, Indo-West Pacific, Indian Ocean, molecular systematics, Phylogeny, 030304 developmental biology, 0303 health sciences, geography, geography.geographical_feature_category, [SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE], Pacific Ocean, General Immunology and Microbiology, biology, Base Sequence, Ecology, Coral Reefs, Haplotype, General Medicine, DNA, biology.organism_classification, Eagle ray, Molecular phylogenetics, Batoidea, Coral Sea, General Agricultural and Biological Sciences, Maskray
Abstract: International audience; The maskray from New Caledonia, Neotrygon trigonoides Castelnau, 1873, has been recently synonymized with the blue-spotted maskray, N. kuhlii (Müller and Henle, 1841), a species with wide Indo-West Pacific distribution, but the reasons for this are unclear. Blue-spotted maskray specimens were collected from the Indian Ocean (Tanzania, Sumatra) and the Coral Triangle (Indonesia, Taiwan, and West Papua), and N. trigonoides specimens were collected from New Caledonia (Coral Sea). Their partial COI gene sequences were generated to expand the available DNA-barcode database on this species, which currently comprises homologous sequences from Ningaloo Reef, the Coral Triangle and the Great Barrier Reef (Coral Sea). Spotting patterns were also compared across regions. Haplotypes from the Coral Sea formed a haplogroup phylogenetically distinct from all other haplotypes sampled in the Indo-West Pacific. No clear-cut geographic composition relative to DNA barcodes or spotting patterns was apparent in N. kuhlii samples across the Indian Ocean and the Coral Triangle. The New Caledonian maskray had spotting patterns markedly different from all the other samples. This, added to a substantial level of net nucleotide divergence (2.6 %) with typical N. kuhlii justifies considering the New Caledonian maskray as a separate species, for which we propose to resurrect the name Neotrygon trigonoides.
Published: 2012

21. Association of polygenic score for major depression with response to lithium in patients with bipolar disorder

Author: Amare, Azmeraw T., Schubert, Klaus Oliver, Hou, Liping, Clark, Scott R., Papiol, Sergi, Cearns, Micah, Heilbronner, Urs, Degenhardt, Franziska, Tekola-Ayele, Fasil, Hsu, Yi Hsiang, Shekhtman, Tatyana, Adli, Mazda, Akula, Nirmala, Akiyama, Kazufumi, Ardau, Raffaella, Arias, Bárbara, Aubry, Jean Michel, Backlund, Lena, Bhattacharjee, Abesh Kumar, Bellivier, Frank, Benabarre, Antonio, Bengesser, Susanne, Biernacka, Joanna M., Birner, Armin, Brichant-Petitjean, Clara, Cervantes, Pablo, Chen, Hsi Chung, Chillotti, Caterina, Cichon, Sven, Cruceanu, Cristiana, Czerski, Piotr M., Dalkner, Nina, Dayer, Alexandre, Del Zompo, Maria, DePaulo, J. Raymond, Étain, Bruno, Jamain, Stephane, Falkai, Peter, Forstner, Andreas J., Frisen, Louise, Frye, Mark A., Fullerton, Janice M., Gard, Sébastien, Garnham, Julie S., Goes, Fernando S., Grigoroiu-Serbanescu, Maria, Grof, Paul, Hashimoto, Ryota, Hauser, Joanna, Herms, Stefan, Hoffmann, Per, Hofmann, Andrea, Jiménez, Esther, Kahn, Jean Pierre, Kassem, Layla, Kuo, Po Hsiu, Kato, Tadafumi, Kelsoe, John R., Kittel-Schneider, Sarah, Kliwicki, Sebastian, König, Barbara, Kusumi, Ichiro, Laje, Gonzalo, Landén, Mikael, Lavebratt, Catharina, Leboyer, Marion, Leckband, Susan G., Tortorella, Alfonso, Manchia, Mirko, Martinsson, Lina, McCarthy, Michael J., McElroy, Susan L., Colom, Francesc, Mitjans, Marina, Mondimore, Francis M., Monteleone, Palmiero, Nievergelt, Caroline M., Nöthen, Markus M., Novák, Tomas, O’Donovan, Claire, Ozaki, Norio, Ösby, Urban, Pfennig, Andrea, Potash, James B., Reif, Andreas, Wray, Naomi R., Ripke, Stephan, Mattheisen, Manuel, Trzaskowski, Maciej, Byrne, Enda M., Abdellaoui, Abdel, Adams, Mark J., Agerbo, Esben, Air, Tracy M., Andlauer, Till F.M., Bacanu, Silviu Alin, Bækvad-Hansen, Marie, Beekman, Aartjan T.F., Bigdeli, Tim B., Binder, Elisabeth B., Blackwood, Douglas H.R., Bryois, Julien, Buttenschøn, Henriette N., Bybjerg-Grauholm, Jonas, Cai, Na, Castelao, Enrique, Christensen, Jane varregaard, Clarke, Toni Kim, Coleman, Jonathan R.I., Colodro-Conde, Lucía, Couvy-Duchesne, Baptiste, Craddock, Nick, Crawford, Gregory E., Davies, Gail, Deary, Ian J., Derks, Eske M., Direk, Nese, Dolan, Conor V., Dunn, Erin C., Eley, Thalia C., Escott-Price, Valentina, Kiadeh, Farnush Farhadi Hassan, Finucane, Hilary K., Frank, Josef, Gaspar, Héléna A., Gill, Michael, Gordon, Scott D., Grove, Jakob, Hall, Lynsey S., Hansen, Christine Søholm, Hansen, Thomas F., Hickie, Ian B., Homuth, Georg, Horn, Carsten, Hottenga, Jouke Jan, Hougaard, David M., Ising, Marcus, Jansen, Rick, Jorgenson, Eric, Knowles, James A., Kohane, Isaac S., Kraft, Julia, Kretzschmar, Warren W., Krogh, Jesper, Kutalik, Zoltán, Li, Yihan, Lind, Penelope A., MacIntyre, Donald J., MacKinnon, Dean F., Maier, Robert M., Maier, Wolfgang, Marchini, Jonathan, Mbarek, Hamdi, McGrath, Patrick, McGuffin, Peter, Medland, Sarah E., Mehta, Divya, Middeldorp, Christel M., Mihailov, Evelin, Milaneschi, Yuri, Milani, Lili, Montgomery, Grant W., Mostafavi, Sara, Mullins, Niamh, Nauck, Matthias, Ng, Bernard, Nivard, Michel G., Nyholt, Dale R., O’Reilly, Paul F., Oskarsson, Hogni, Owen, Michael J., Painter, Jodie N., Pedersen, Carsten Bøcker, Pedersen, Marianne Giørtz, Peterson, Roseann E., Pettersson, Erik, Peyrot, Wouter J., Pistis, Giorgio, Posthuma, Danielle, Quiroz, Jorge A., Qvist, Per, Rice, John P., Riley, Brien P., Rivera, Margarita, Mirza, Saira Saeed, Schoevers, Robert, Schulte, Eva C., Shen, Ling, Shi, Jianxin, Shyn, Stanley I., Sigurdsson, Engilbert, Sinnamon, Grant C.B., Smit, Johannes H., Smith, Daniel J., Stefansson, Hreinn, Steinberg, Stacy, Streit, Fabian, Strohmaier, Jana, Tansey, Katherine E., Teismann, Henning, Teumer, Alexander, Thompson, Wesley, Thomson, Pippa A., Thorgeirsson, Thorgeir E., Traylor, Matthew, Treutlein, Jens, Trubetskoy, Vassily, Uitterlinden, André G., Umbricht, Daniel, Van der Auwera, Sandra, van Hemert, Albert M., Viktorin, Alexander, Visscher, Peter M., Wang, Yunpeng, Webb, Bradley T., Weinsheimer, Shantel Marie, Wellmann, Jürgen, Willemsen, Gonneke, Witt, Stephanie H., Wu, Yang, Xi, Hualin S., Yang, Jian, Zhang, Futao, Arolt, Volker, Baune, Bernhard T., Berger, Klaus, Boomsma, Dorret I., Dannlowski, Udo, de Geus, E. J.C., Domenici, Enrico, Domschke, Katharina, Esko, Tõnu, Grabe, Hans J., Hamilton, Steven P., Hayward, Caroline, Heath, Andrew C., Kendler, Kenneth S., Kloiber, Stefan, Lewis, Glyn, Li, Qingqin S., Lucae, Susanne, Madden, Pamela A.F., Magnusson, Patrik K., Martin, Nicholas G., McIntosh, Andrew M., Metspalu, Andres, Mors, Ole, Mortensen, Preben Bo, Müller-Myhsok, Bertram, Nordentoft, Merete, O’Donovan, Michael C., Paciga, Sara A., Pedersen, Nancy L., Penninx, Brenda W.J.H., Perlis, Roy H., Porteous, David J., Preisig, Martin, Rietschel, Marcella, Schaefer, Catherine, Schulze, Thomas G., Smoller, Jordan W., Stefansson, Kari, Tiemeier, Henning, Uher, Rudolf, Völzke, Henry, Weissman, Myrna M., Werge, Thomas, Lewis, Cathryn M., Levinson, Douglas F., Breen, Gerome, Børglum, Anders D., Sullivan, Patrick F., Reininghaus, Eva, Rouleau, Guy A., Rybakowski, Janusz K., Schalling, Martin, Schofield, Peter R., Schweizer, Barbara W., Severino, Giovanni, Shilling, Paul D., Shimoda, Katzutaka, Simhandl, Christian, Slaney, Claire M., Squassina, Alessio, Stamm, Thomas, Stopkova, Pavla, Maj, Mario, Turecki, Gustavo, Vieta, Eduard, Veeh, Julia, Wright, Adam, Zandi, Peter P., Mitchell, Philip B., Bauer, Michael, Alda, Martin, McMahon, Francis J., APH - Mental Health, Amsterdam Neuroscience - Mood, Anxiety, Psychosis, Stress & Sleep, Psychiatry, Amsterdam Neuroscience - Complex Trait Genetics, Amsterdam Reproduction & Development (AR&D), Amsterdam Neuroscience - Compulsivity, Impulsivity & Attention, Amsterdam Neuroscience - Cellular & Molecular Mechanisms, Human genetics, APH - Digital Health, APH - Methodology, Biological Psychology, APH - Personalized Medicine, APH - Health Behaviors & Chronic Diseases, Complex Trait Genetics, Clinical Cognitive Neuropsychiatry Research Program (CCNP), Interdisciplinary Centre Psychopathology and Emotion regulation (ICPE), Jamain, Stéphane, University of Adelaide, South Australian Health and Medical Research Institute [ Adelaide] (SAHMRI), Mental Health Services [Adelaide, SA, Australia], National Institute of Mental Health (NIMH), Ludwig Maximilian University [Munich] (LMU), Georg-August-University = Georg-August-Universität Göttingen, Institut für Genetik - Universität Bonn / Institute of Genetics - University of Bonn, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Harvard Medical School [Boston] (HMS), Harvard School of Public Health, University of California [San Diego] (UC San Diego), University of California (UC), Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Dokkyo Medical University, Università degli Studi di Cagliari = University of Cagliari (UniCa), Universitat Autònoma de Barcelona (UAB), Centro de Investigación Biomédica en Red de Salud Mental [Barcelona, Spain] (CIBERSAM), Hospital Sant Joan de Déu [Barcelona], Geneva University Hospital (HUG), Karolinska Institutet [Stockholm], Karolinska University Hospital [Stockholm], Optimisation thérapeutique en Neuropsychopharmacologie (OPTeN (UMR_S_1144 / U1144)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona (UB), Karl-Franzens-Universität Graz, Mayo Clinic [Rochester], McGill University Health Center [Montreal] (MUHC), National Taiwan University [Taiwan] (NTU), University Hospital Basel [Basel], Poznan University of Medical Sciences [Poland] (PUMS), Johns Hopkins University (JHU), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Fondation FondaMental [Créteil], IMRB - 'Neuropsychiatrie translationnelle' [Créteil] (U955 Inserm - UPEC), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), University of Basel (Unibas), Neuroscience Research Australia [Sydney, NSW, Australia] (NRA), University of New South Wales [Sydney] (UNSW), Psychiatrie de l'enfant et de l'adolescent [CH C. Perrens, Bordeaux], SECOP - centre hospitalier Charles Perrens, Dalhousie University [Halifax], 'Prof. Dr. Alexandru Obregia' Clinical Hospital of Psychiatry [Bucharest, Romania], Mood Disorders Center of Ottawa (MDCO), University of Ottawa [Ottawa], Osaka University [Osaka], Graduate School of Medicine [Osaka], Centro de Investigación Biomédica en Red Salud Mental [Madrid] (CIBER-SAM), Psychiatrie et Psychologie Clinique de Liaison [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Centre Psychothérapique de Nancy (CPN), National Institutes of Health [Bethesda] (NIH), Environmental Molecular Biology Laboratory (RIKEN), RIKEN - Institute of Physical and Chemical Research [Japon] (RIKEN), Goethe-University Frankfurt am Main, Landesklinikum Neunkirchen (LK Neunkirchen), Hokkaido University Graduate School of Medicine [Sapporo, Japan], Sahlgrenska Academy at University of Gothenburg [Göteborg], Research Service VA San Diego Healthcare System, Università degli Studi di Perugia = University of Perugia (UNIPG), University of Cincinnati (UC), IMIM-Hospital del Mar, Generalitat de Catalunya, Max Planck Institute of Experimental Medicine [Göttingen] (MPI), Max-Planck-Gesellschaft, University of Salerno (UNISA), University of the Study of Campania Luigi Vanvitelli, National Institute of Mental Health [Klecany, Czech Republic] (NIMH), Nagoya University Graduate School of Medicine [Japon], Technische Universität Dresden = Dresden University of Technology (TU Dresden), Medical University Graz, Montreal Neurological Institute and Hospital, McGill University = Université McGill [Montréal, Canada], Sigmund Freud University (SFU), Douglas Mental Health University Institute [Montréal], University of Heidelberg, Medical Faculty, Black Dog Institute [Sydney, Australia], Johns Hopkins Bloomberg School of Public Health [Baltimore], Westfälische Wilhelms-Universität Münster = University of Münster (WWU), Melbourne Medical School [Melbourne], Faculty of Medicine, Dentistry and Health Sciences [Melbourne], University of Melbourne-University of Melbourne, The Florey Institute of Neuroscience and Mental Health [Parkville, VIC, Australie], University of Melbourne, Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium: Naomi R Wray, Stephan Ripke, Manuel Mattheisen, Maciej Trzaskowski, Enda M Byrne, Abdel Abdellaoui, Mark J Adams, Esben Agerbo, Tracy M Air, Till F M Andlauer, Silviu-Alin Bacanu, Marie Bækvad-Hansen, Aartjan T F Beekman, Tim B Bigdeli, Elisabeth B Binder, Douglas H R Blackwood, Julien Bryois, Henriette N Buttenschøn, Jonas Bybjerg-Grauholm, Na Cai, Enrique Castelao, Jane Varregaard Christensen, Toni-Kim Clarke, Jonathan R I Coleman, Lucía Colodro-Conde, Baptiste Couvy-Duchesne, Nick Craddock, Gregory E Crawford, Gail Davies, Ian J Deary, Franziska Degenhardt, Eske M Derks, Nese Direk, Conor V Dolan, Erin C Dunn, Thalia C Eley, Valentina Escott-Price, Farnush Farhadi Hassan Kiadeh, Hilary K Finucane, Andreas J Forstner, Josef Frank, Héléna A Gaspar, Michael Gill, Fernando S Goes, Scott D Gordon, Jakob Grove, Lynsey S Hall, Christine Søholm Hansen, Thomas F Hansen, Stefan Herms, Ian B Hickie, Per Hoffmann, Georg Homuth, Carsten Horn, Jouke-Jan Hottenga, David M Hougaard, Marcus Ising, Rick Jansen, Eric Jorgenson, James A Knowles, Isaac S Kohane, Julia Kraft, Warren W Kretzschmar, Jesper Krogh, Zoltán Kutalik, Yihan Li, Penelope A Lind, Donald J MacIntyre, Dean F MacKinnon, Robert M Maier, Wolfgang Maier, Jonathan Marchini, Hamdi Mbarek, Patrick McGrath, Peter McGuffin, Sarah E Medland, Divya Mehta, Christel M Middeldorp, Evelin Mihailov, Yuri Milaneschi, Lili Milani, Francis M Mondimore, Grant W Montgomery, Sara Mostafavi, Niamh Mullins, Matthias Nauck, Bernard Ng, Michel G Nivard, Dale R Nyholt, Paul F O'Reilly, Hogni Oskarsson, Michael J Owen, Jodie N Painter, Carsten Bøcker Pedersen, Marianne Giørtz Pedersen, Roseann E Peterson, Erik Pettersson, Wouter J Peyrot, Giorgio Pistis, Danielle Posthuma, Jorge A Quiroz, Per Qvist, John P Rice, Brien P Riley, Margarita Rivera, Saira Saeed Mirza, Robert Schoevers, Eva C Schulte, Ling Shen, Jianxin Shi, Stanley I Shyn, Engilbert Sigurdsson, Grant C B Sinnamon, Johannes H Smit, Daniel J Smith, Hreinn Stefansson, Stacy Steinberg, Fabian Streit, Jana Strohmaier, Katherine E Tansey, Henning Teismann, Alexander Teumer, Wesley Thompson, Pippa A Thomson, Thorgeir E Thorgeirsson, Matthew Traylor, Jens Treutlein, Vassily Trubetskoy, André G Uitterlinden, Daniel Umbricht, Sandra Van der Auwera, Albert M van Hemert, Alexander Viktorin, Peter M Visscher, Yunpeng Wang, Bradley T Webb, Shantel Marie Weinsheimer, Jürgen Wellmann, Gonneke Willemsen, Stephanie H Witt, Yang Wu, Hualin S Xi, Jian Yang, Futao Zhang, Volker Arolt, Bernhard T Baune, Klaus Berger, Dorret I Boomsma, Sven Cichon, Udo Dannlowski, E J C de Geus, J Raymond DePaulo, Enrico Domenici, Katharina Domschke, Tõnu Esko, Hans J Grabe, Steven P Hamilton, Caroline Hayward, Andrew C Heath, Kenneth S Kendler, Stefan Kloiber, Glyn Lewis, Qingqin S Li, Susanne Lucae, Pamela A F Madden, Patrik K Magnusson, Nicholas G Martin, Andrew M McIntosh, Andres Metspalu, Ole Mors, Preben Bo Mortensen, Bertram Müller-Myhsok, Merete Nordentoft, Markus M Nöthen, Michael C O'Donovan, Sara A Paciga, Nancy L Pedersen, Brenda W J H Penninx, Roy H Perlis, David J Porteous, James B Potash, Martin Preisig, Marcella Rietschel, Catherine Schaefer, Thomas G Schulze, Jordan W Smoller, Kari Stefansson, Henning Tiemeier, Rudolf Uher, Henry Völzke, Myrna M Weissman, Thomas Werge, Cathryn M Lewis, Douglas F Levinson, Gerome Breen, Anders D Børglum, Patrick F Sullivan., Epidemiology, Internal Medicine, Child and Adolescent Psychiatry / Psychology, Georg-August-University [Göttingen], University of California, Universita degli Studi di Cagliari [Cagliari], Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Paris (UP), University of Graz, Università degli Studi di Perugia (UNIPG), University of Münster, Karl-Franzens-Universität [Graz, Autriche], Amare, A. T., Schubert, K. O., Hou, L., Clark, S. R., Papiol, S., Cearns, M., Heilbronner, U., Degenhardt, F., Tekola-Ayele, F., Hsu, Y. -H., Shekhtman, T., Adli, M., Akula, N., Akiyama, K., Ardau, R., Arias, B., Aubry, J. -M., Backlund, L., Bhattacharjee, A. K., Bellivier, F., Benabarre, A., Bengesser, S., Biernacka, J. M., Birner, A., Brichant-Petitjean, C., Cervantes, P., Chen, H. -C., Chillotti, C., Cichon, S., Cruceanu, C., Czerski, P. M., Dalkner, N., Dayer, A., Del Zompo, M., Depaulo, J. R., Etain, B., Jamain, S., Falkai, P., Forstner, A. J., Frisen, L., Frye, M. A., Fullerton, J. M., Gard, S., Garnham, J. S., Goes, F. S., Grigoroiu-Serbanescu, M., Grof, P., Hashimoto, R., Hauser, J., Herms, S., Hoffmann, P., Hofmann, A., Jimenez, E., Kahn, J. -P., Kassem, L., Kuo, P. -H., Kato, T., Kelsoe, J. R., Kittel-Schneider, S., Kliwicki, S., Konig, B., Kusumi, I., Laje, G., Landen, M., Lavebratt, C., Leboyer, M., Leckband, S. G., Tortorella, A., Manchia, M., Martinsson, L., Mccarthy, M. J., Mcelroy, S. L., Colom, F., Mitjans, M., Mondimore, F. M., Monteleone, P., Nievergelt, C. M., Nothen, M. M., Novak, T., O'Donovan, C., Ozaki, N., Osby, U., Pfennig, A., Potash, J. B., Reif, A., Wray, N. R., Ripke, S., Mattheisen, M., Trzaskowski, M., Byrne, E. M., Abdellaoui, A., Adams, M. J., Agerbo, E., Air, T. M., Andlauer, T. F. M., Bacanu, S. -A., Baekvad-Hansen, M., Beekman, A. T. F., Bigdeli, T. B., Binder, E. B., Blackwood, D. H. R., Bryois, J., Buttenschon, H. N., Bybjerg-Grauholm, J., Cai, N., Castelao, E., Christensen, J., Clarke, T. -K., Coleman, J. R. I., Colodro-Conde, L., Couvy-Duchesne, B., Craddock, N., Crawford, G. E., Davies, G., Deary, I. J., Derks, E. M., Direk, N., Dolan, C. V., Dunn, E. C., Eley, T. C., Escott-Price, V., Kiadeh, F. F. H., Finucane, H. K., Frank, J., Gaspar, H. A., Gill, M., Gordon, S. D., Grove, J., Hall, L. S., Hansen, C. S., Hansen, T. F., Hickie, I. B., Homuth, G., Horn, C., Hottenga, J. -J., Hougaard, D. M., Ising, M., Jansen, R., Jorgenson, E., Knowles, J. A., Kohane, I. S., Kraft, J., Kretzschmar, W. W., Krogh, J., Kutalik, Z., Li, Y., Lind, P. A., Macintyre, D. J., Mackinnon, D. F., Maier, R. M., Maier, W., Marchini, J., Mbarek, H., Mcgrath, P., Mcguffin, P., Medland, S. E., Mehta, D., Middeldorp, C. M., Mihailov, E., Milaneschi, Y., Milani, L., Montgomery, G. W., Mostafavi, S., Mullins, N., Nauck, M., Ng, B., Nivard, M. G., Nyholt, D. R., O'Reilly, P. F., Oskarsson, H., Owen, M. J., Painter, J. N., Pedersen, C. B., Pedersen, M. G., Peterson, R. E., Pettersson, E., Peyrot, W. J., Pistis, G., Posthuma, D., Quiroz, J. A., Qvist, P., Rice, J. P., Riley, B. P., Rivera, M., Mirza, S. S., Schoevers, R., Schulte, E. C., Shen, L., Shi, J., Shyn, S. I., Sigurdsson, E., Sinnamon, G. C. B., Smit, J. H., Smith, D. J., Stefansson, H., Steinberg, S., Streit, F., Strohmaier, J., Tansey, K. E., Teismann, H., Teumer, A., Thompson, W., Thomson, P. A., Thorgeirsson, T. E., Traylor, M., Treutlein, J., Trubetskoy, V., Uitterlinden, A. G., Umbricht, D., Van der Auwera, S., van Hemert, A. M., Viktorin, A., Visscher, P. M., Wang, Y., Webb, B. T., Weinsheimer, S. M., Wellmann, J., Willemsen, G., Witt, S. H., Wu, Y., Xi, H. S., Yang, J., Zhang, F., Arolt, V., Baune, B. T., Berger, K., Boomsma, D. I., Dannlowski, U., de Geus, E. J. C., Domenici, E., Domschke, K., Esko, T., Grabe, H. J., Hamilton, S. P., Hayward, C., Heath, A. C., Kendler, K. S., Kloiber, S., Lewis, G., Li, Q. S., Lucae, S., Madden, P. A. F., Magnusson, P. K., Martin, N. G., Mcintosh, A. M., Metspalu, A., Mors, O., Mortensen, P. B., Muller-Myhsok, B., Nordentoft, M., O'Donovan, M. C., Paciga, S. A., Pedersen, N. L., Penninx, B. W. J. H., Perlis, R. H., Porteous, D. J., Preisig, M., Rietschel, M., Schaefer, C., Schulze, T. G., Smoller, J. W., Stefansson, K., Tiemeier, H., Uher, R., Volzke, H., Weissman, M. M., Werge, T., Lewis, C. M., Levinson, D. F., Breen, G., Borglum, A. D., Sullivan, P. F., Reininghaus, E., Rouleau, G. A., Rybakowski, J. K., Schalling, M., Schofield, P. R., Schweizer, B. W., Severino, G., Shilling, P. D., Shimoda, K., Simhandl, C., Slaney, C. M., Squassina, A., Stamm, T., Stopkova, P., Maj, M., Turecki, G., Vieta, E., Veeh, J., Wright, A., Zandi, P. P., Mitchell, P. B., Bauer, M., Alda, M., Mcmahon, F. J., and Adult Psychiatry
Subjects: 0301 basic medicine, Netherlands Twin Register (NTR), Lithium (medication), [SDV.MHEP.PSM] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, Genome-wide association study, Logistic regression, THERAPY, ddc:616.89, 0302 clinical medicine, Medicine, Major depression, PREDICTORS, Depression (differential diagnoses), RISK, Depression, Psychiatry and Mental health, Quartile, Cohort, AUGMENTATION, medicine.drug, POLARITY, medicine.medical_specialty, GENETICS, Bipolar disorder, [SDV.GEN.GH] Life Sciences [q-bio]/Genetics/Human genetics, Lithium, PROPHYLACTIC LITHIUM, 03 medical and health sciences, Cellular and Molecular Neuroscience, SDG 3 - Good Health and Well-being, Internal medicine, Humans, ddc:610, AGENTS, Molecular Biology, Genetic association, Depressive Disorder, Major, business.industry, medicine.disease, EFFICACY, 030104 developmental biology, [SDV.GEN.GH]Life Sciences [q-bio]/Genetics/Human genetics, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, PHARMACOLOGICAL-TREATMENTS, business, 030217 neurology & neurosurgery, Genome-Wide Association Study
Abstract: © 2020, The Author(s), under exclusive licence to Springer Nature Limited.Lithium is a first-line medication for bipolar disorder (BD), but only one in three patients respond optimally to the drug. Since evidence shows a strong clinical and genetic overlap between depression and bipolar disorder, we investigated whether a polygenic susceptibility to major depression is associated with response to lithium treatment in patients with BD. Weighted polygenic scores (PGSs) were computed for major depression (MD) at different GWAS p value thresholds using genetic data obtained from 2586 bipolar patients who received lithium treatment and took part in the Consortium on Lithium Genetics (ConLi+Gen) study. Summary statistics from genome-wide association studies in MD (135,458 cases and 344,901 controls) from the Psychiatric Genomics Consortium (PGC) were used for PGS weighting. Response to lithium treatment was defined by continuous scores and categorical outcome (responders versus non-responders) using measurements on the Alda scale. Associations between PGSs of MD and lithium treatment response were assessed using a linear and binary logistic regression modeling for the continuous and categorical outcomes, respectively. The analysis was performed for the entire cohort, and for European and Asian sub-samples. The PGSs for MD were significantly associated with lithium treatment response in multi-ethnic, European or Asian populations, at various p value thresholds. Bipolar patients with a low polygenic load for MD were more likely to respond well to lithium, compared to those patients with high polygenic load [lowest vs highest PGS quartiles, multi-ethnic sample: OR = 1.54 (95% CI: 1.18–2.01) and European sample: OR = 1.75 (95% CI: 1.30–2.36)]. While our analysis in the Asian sample found equivalent effect size in the same direction: OR = 1.71 (95% CI: 0.61–4.90), this was not statistically significant. Using PGS decile comparison, we found a similar trend of association between a high genetic loading for MD and lower response to lithium. Our findings underscore the genetic contribution to lithium response in BD and support the emerging concept of a lithium-responsive biotype in BD.
Published: 2021

22. Idiopathic interstitial pneumonias and emphysema: detection and classification using a texture-discriminative approach

Author: Catalin Fetita, Kuang-Che Chang-Chien, Francoise Preteux, Pierre-Yves Brillet, Ruey-Feng Chang, Département Advanced Research And Techniques For Multidimensional Imaging Systems (ARTEMIS), Institut Mines-Télécom [Paris] (IMT)-Télécom SudParis (TSP), Mathématiques Appliquées Paris 5 (MAP5 - UMR 8145), Université Paris Descartes - Paris 5 (UPD5)-Institut National des Sciences Mathématiques et de leurs Interactions (INSMI)-Centre National de la Recherche Scientifique (CNRS), National Chung Cheng University, Réponses Cellulaires et Fonctionnelles à l'Hypoxie (LRPH), Université Paris 13 (UP13)-Université Sorbonne Paris Cité (USPC)-UFR SMBH, École des Mines de Paris, National Taiwan University [Taiwan] (NTU), Département Advanced Research And Techniques For Multidimensional Imaging Systems ( ARTEMIS ), Institut Mines-Télécom [Paris]-Télécom SudParis ( TSP ), Mathématiques Appliquées à Paris 5 ( MAP5 - UMR 8145 ), Université Paris Descartes - Paris 5 ( UPD5 ) -Institut National des Sciences Mathématiques et de leurs Interactions-Centre National de la Recherche Scientifique ( CNRS ), Réponses Cellulaires et Fonctionnelles à l'Hypoxie ( LRPH ), Université Paris 13 ( UP13 ) -Université Sorbonne Paris Cité ( USPC ) -UFR SMBH, and National Taiwan University [Taiwan] ( NTU )
Subjects: [ INFO.INFO-TS ] Computer Science [cs]/Signal and Image Processing, Computer science, Computed tomography, [ SPI.SIGNAL ] Engineering Sciences [physics]/Signal and Image processing, Mathematical morphology, Fuzzy logic, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, [INFO.INFO-TS]Computer Science [cs]/Signal and Image Processing, Discriminative model, Fibrosis, Parenchyma, medicine, 030212 general & internal medicine, Lung region, Honeycombing, Pyramid (image processing), Idiopathic interstitial pneumonia, Lung, medicine.diagnostic_test, business.industry, Pattern recognition, medicine.disease, 3. Good health, medicine.anatomical_structure, Computer-aided diagnosis, Artificial intelligence, Lung tissue, business, [SPI.SIGNAL]Engineering Sciences [physics]/Signal and Image processing
Abstract: International audience; Our study aims at developing a computer-aided diagnosis (CAD) system for fully automatic detection and classification of pathological lung parenchyma patterns in idiopathic interstitial pneumonias (IIP) and emphysema using multi-detector computed tomography (MDCT). The proposed CAD system is based on three-dimensional (3-D) mathematical morphology, texture and fuzzy logic analysis, and can be divided into four stages: (1) a multi-resolution decomposition scheme based on a 3-D morphological filter was exploited to discriminate the lung region patterns at different analysis scales. (2) An additional spatial lung partitioning based on the lung tissue texture was introduced to reinforce the spatial separation between patterns extracted at the same resolution level in the decomposition pyramid. Then, (3) a hierarchic tree structure was exploited to describe the relationship between patterns at different resolution levels, and for each pattern, six fuzzy membership functions were established for assigning a probability of association with a normal tissue or a pathological target. Finally, (4) a decision step exploiting the fuzzy-logic assignments selects the target class of each lung pattern among the following categories: normal (N), emphysema (EM), fibrosis/honeycombing (FHC), and ground glass (GDG). According to a preliminary evaluation on an extended database, the proposed method can overcome the drawbacks of a previously developed approach and achieve higher sensitivity and specificity.
Published: 2012

23. Genetic fuzzy markup language for game of NoGo

Author: Mei-Hui Wang, Hani Hagras, Yu-Jen Chen, Olivier Teytaud, Meng-Jhen Wu, Chang-Shing Lee, OASE, Institute of Computer Science and Information Engineering [Taiwan] (Institute of CSIE), National Taiwan University [Taiwan] (NTU)-National Taiwan University [Taiwan] (NTU), National University of Tainan (NUTN), National Taiwan University [Taiwan] (NTU), OASE, National University of Tainan, Taiwan (OASE), Fuzzy Systems Research Group, University of Essex, Machine Learning and Optimisation (TAO), Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Université Paris-Sud - Paris 11 (UP11)-Laboratoire de Recherche en Informatique (LRI), Université Paris-Sud - Paris 11 (UP11)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-CentraleSupélec, Laboratoire de Recherche en Informatique (LRI), Université Paris-Sud - Paris 11 (UP11)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, and Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)
Subjects: Information Systems and Management, Fuzzy markup language, business.industry, Computer science, Monte Carlo tree search, 020206 networking & telecommunications, 02 engineering and technology, Construct (python library), Ontology (information science), Fuzzy logic, Evolutionary computation, Management Information Systems, Artificial Intelligence, Genetic algorithm, 0202 electrical engineering, electronic engineering, information engineering, 020201 artificial intelligence & image processing, Artificial intelligence, [MATH.MATH-OC]Mathematics [math]/Optimization and Control [math.OC], business, Software, ComputingMilieux_MISCELLANEOUS
Abstract: NoGo is similar to the game of Go in terms of gameplay; however, the goal is different: the first player who either suicides or kills a group loses the game and the first player with no legal move loses the game. In this paper, we propose an approach combining the technologies of ontologies, evolutionary computation, fuzzy logic, and fuzzy markup language (FML) with a genetic algorithm (GA)-based system for the NoGo game. Based on the collected patterns and the pre-constructed fuzzy NoGo ontology, the genetic FML (GFML) with the fuzzy inference mechanism is able to analyze the situation of the current game board and then play next move to an inferred good-move position. Additionally, the genetic learning mechanism continuously evolves the adopted GFMLs to enable an increase in the winning rate of the GA-based NoGo via playing with the baseline NoGo. In the proposed approach, first, the domain experts construct the important NoGo patterns and the fuzzy NoGo ontology based on the rules of NoGo and the past game records. Second, each GA-based NoGo as White plays against the baseline NoGo as Black according to the inferred and calculated good-move position, respectively. Third, the genetic learning mechanism is carried out to generate two new evolved GFMLs and then the worst two GFMLs stored in the GFML repository are replaced. Fourth, the GFML with the highest winning rate is randomly sampled from the GFML repository in the time series. Finally, one by one the GA-based NoGo adopts the sampled GFML to play lots of games against the baseline NoGo to obtain the winning rate of the GA-based NoGo. The acquired winning rates at the time series show that the proposed approach can work effectively and that the average winning rate of the GA-based NoGo program is much stronger than the baseline NoGo program.
Published: 2012

24. Strategic Choices: Small Budgets and Simple Regret

Author: Chang-Shing Lee, Cheng-Wei Chou, Li-Wen Wu, Mei-Hui Wang, Ping-Chiang Chou, Shi-Jim Yen, David L. Saint-Pierre, Olivier Teytaud, National Dong Hwa University (NDHU), Go expert, Go Expert, OASE, Institute of Computer Science and Information Engineering [Taiwan] (Institute of CSIE), National Taiwan University [Taiwan] (NTU)-National Taiwan University [Taiwan] (NTU), Département d'Electricité, Electronique & Informatique (Institut Montefiore), Université de Liège, Machine Learning and Optimisation (TAO), Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Université Paris-Sud - Paris 11 (UP11)-Laboratoire de Recherche en Informatique (LRI), Université Paris-Sud - Paris 11 (UP11)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-CentraleSupélec, Laboratoire de Recherche en Informatique (LRI), Université Paris-Sud - Paris 11 (UP11)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS), National University of Tainan (NUTN), National Taiwan University [Taiwan] (NTU), OASE, National University of Tainan, Taiwan (OASE), indema, Université Paris-Sud - Paris 11 (UP11)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, and Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)
Subjects: Mathematical optimization, Computer science, media_common.quotation_subject, 020207 software engineering, Regret, 02 engineering and technology, Decision problem, Empirical distribution function, Simple (abstract algebra), 0202 electrical engineering, electronic engineering, information engineering, 020201 artificial intelligence & image processing, Relevance (information retrieval), Quality (business), Truncation (statistics), [MATH.MATH-OC]Mathematics [math]/Optimization and Control [math.OC], Game theory, media_common
Abstract: International audience; In many decision problems, there are two levels of choice: The first one is strategic and the second is tactical. We formalize the difference between both and discuss the relevance of the bandit literature for strate- gic decisions and test the quality of different bandit algorithms in real world examples such as board games and card games. For exploration- exploitation algorithm, we evaluate the Upper Confidence Bounds and Exponential Weights, as well as algorithms designed for simple regret, such as Successive Reject. For the exploitation, we also evaluate Bern- stein Races and Uniform Sampling. As for the recommandation part, we test Empirically Best Arm, Most Played, Lower Confidence Bounds and Empirical Distribution. In the one-player case, we recommend Up- per Confidence Bound as an exploration algorithm (and in particular its variants adaptUCBE for parameter-free simple regret) and Lower Confi- dence Bound or Most Played Arm as recommendation algorithms. In the two-player case, we point out the commodity and efficiency of the EXP3 algorithm, and the very clear improvement provided by the truncation algorithm TEXP3. Incidentally our algorithm won some games against professional players in kill-all Go (to the best of our knowledge, for the first time in computer games).
Published: 2012

25. Genus-level taxonomic changes implied by the mitochondrial phylogeny of grey mullets (Teleostei: Mugilidae)

Author: Wei-Jen Chen, Philippe Borsa, Jean-Dominique Durand, Cuizhang Fu, Kang-Ning Shen, Ecologie des systèmes marins côtiers (Ecosym), Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Centre National de la Recherche Scientifique (CNRS), Inst. Oceanogr. National Taiwan University, Oceanography Institute, National Taiwan University [Taiwan] (NTU)-National Taiwan University [Taiwan] (NTU), Institute of Fisheries Science, National Taiwan University [Taiwan] (NTU), Institute of Biodiversity Science at Fudan University [Shanghai] (IBSFU), Biocomplexité des écosystèmes coralliens de l'Indo-Pacifique (CoReUS2), and Université Montpellier 1 (UM1)-Université Montpellier 2 - Sciences et Techniques (UM2)-Institut Français de Recherche pour l'Exploitation de la Mer (IFREMER)-Centre National de la Recherche Scientifique (CNRS)
Subjects: 0106 biological sciences, Valamugil, Agonostomus, Zoology, Moolgarda seheli, DNA, Mitochondrial, 010603 evolutionary biology, 01 natural sciences, Moolgarda, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, taxonomy, Species Specificity, Animals, Agonostomus monticola, paraphyly, systematics, Molecular Biology, Phylogeny, 030304 developmental biology, 0303 health sciences, [SDV.GEN.GPO]Life Sciences [q-bio]/Genetics/Populations and Evolution [q-bio.PE], General Immunology and Microbiology, biology, Chelon, Mugil, polyphyly, Sequence Analysis, DNA, General Medicine, Classification, biology.organism_classification, Smegmamorpha, Mitochondria, Rhinomugil, nomenclature, General Agricultural and Biological Sciences
Abstract: International audience; A comprehensive mitochondrial phylogeny of the family Mugilidae (Durand et al., Mol. Phylogenet. Evol. 64 (2012) 73-92 [1]) demonstrated the polyphyly or paraphyly of a proportion of the 20 genera in the family. Based on these results, here we propose a revised classification with 25 genera, including 15 genera currently recognized as valid (Agonostomus, Aldrichetta, Cestraeus, Chaenomugil, Chelon, Crenimugil, Ellochelon, Joturus, Mugil, Myxus, Neomyxus, Oedalechilus, Rhinomugil, Sicamugil and Trachystoma), 7 resurrected genera [Dajaus (for Agonostomus monticola), Gracilimugil (for Liza argentea), Minimugil (for Sicamugil cascasia), Osteomugil (for several species currently under Moolgarda and Valamugil, including M. cunnesius, M. engeli, M. perusii, and V. robustus), Planiliza (for Indo-Pacific Chelon spp., Indo-Pacific Liza spp., and Paramugil parmatus), Plicomugil (for Oedalechilus labiosus), and Squalomugil (for Rhinomugil nasutus)] and 3 new genera: Neochelon gen. nov. (for Liza falcipinnis), Parachelon gen. nov. (for L. grandisquamis) and Pseudomyxus gen. nov. (for Myxus capensis). Genus Chelon was shown to include exclusively Chelon spp. and Liza spp. from the Atlantic and the Mediterranean, and Liza spp. species endemic to eastern southern Africa. Genus Crenimugil should now include C. crenilabis, Moolgarda seheli and V. buchanani. Genus names Liza, Moolgarda, Paramugil, Valamugil and Xenomugil should be abandoned because they are no longer valid. Further genetic evidence is required to confirm or infirm the validity of the genus Paracrenimugil Senou 1988. The mitochondrial phylogeny of the 25 genera from the present revision is the following: [(Sicamugil, (Minimugil, Rhinomugil)); Trachystoma; ((Myxus, Neomyxus), (Cestraeus, Chaenomugil, (Agonostomus, Dajaus, Joturus), Mugil)); (Aldrichetta, Gracilimugil); Neochelon gen. nov.; (Pseudomyxus gen. nov., (Chelon, Oedalechilus, Planiliza, Parachelon gen. nov.)); ((Squalomugil, (Ellochelon, Plicomugil)), (Crenimugil, Osteomugil))]. Agonostomus monticola and several species with large distribution ranges (including Moolgarda seheli, Mugil cephalus and M. curema) consist of separate lineages whose geographic distribution suggests they are cryptic species, thus warranting further taxonomic work in the Mugilidae at the infra-generic level.
Published: 2012

26. Optical and Luminescent Properties of CdSe/ZnS and TiO2 Semiconductor Quantum Dots Embedded into PMMA Layers

Author: Valmor Roberto Mastelaro, Alexandre Merlen, Cheng-Chung Lee, Hung-Ju Lin, François Flory, Judikael Le-Rouzo, Sheng Hui Chen, Yu-Jen Chen, Waldir Avansi, Department of Optics and Photonics/ Thin Film Technology Center, National Central University [Taiwan] ( NCU ), Institut des Matériaux, de Microélectronique et des Nanosciences de Provence ( IM2NP ), Aix Marseille Université ( AMU ) -Université de Toulon ( UTLN ) -Centre National de la Recherche Scientifique ( CNRS ), OASE, National University of Tainan, Taiwan ( OASE ), National Taiwan University [Taiwan] ( NTU ), Laboratoire de Physique de l'ENS Lyon ( Phys-ENS ), École normale supérieure - Lyon ( ENS Lyon ) -Université Claude Bernard Lyon 1 ( UCBL ), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique ( CNRS ), Department of Optics and Photonics, Thin Film Technology Center, OPTO-PV, Aix Marseille Université ( AMU ) -Université de Toulon ( UTLN ) -Centre National de la Recherche Scientifique ( CNRS ) -Aix Marseille Université ( AMU ) -Université de Toulon ( UTLN ) -Centre National de la Recherche Scientifique ( CNRS ), Thin Film Technology Center, National Central University [Taiwan] (NCU), Institut des Matériaux, de Microélectronique et des Nanosciences de Provence (IM2NP), Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), OASE, National University of Tainan, Taiwan (OASE), National Taiwan University [Taiwan] (NTU), Laboratoire de Physique de l'ENS Lyon (Phys-ENS), École normale supérieure - Lyon (ENS Lyon)-Centre National de la Recherche Scientifique (CNRS)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), and Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU)-Université de Toulon (UTLN)-Centre National de la Recherche Scientifique (CNRS)
Subjects: Spin coating, Materials science, Absorption spectroscopy, business.industry, Band gap, Exciton, Nanotechnology, Semiconductor, Quantum dot, [SPI.OPTI]Engineering Sciences [physics]/Optics / Photonic, Optoelectronics, [ SPI.NANO ] Engineering Sciences [physics]/Micro and nanotechnologies/Microelectronics, [ SPI.OPTI ] Engineering Sciences [physics]/Optics / Photonic, Thin film, [SPI.NANO]Engineering Sciences [physics]/Micro and nanotechnologies/Microelectronics, business, Luminescence, ComputingMilieux_MISCELLANEOUS
Abstract: Optical quality PMMA thin film layers including different concentrations of 3nm CdSe/ZnS and 5 nm TiO2 semiconductor quantum dots have been made by spin coating method. Their optical properties show evident consequences of the confinement effects with wavelength bandgap shifting for both types of QDs. The confinement effects are more pronounced for CdSe/ZnS QDs than for TiO2 QDs. Layers including CdSe/ZnS QDs exhibit a strong luminescent behavior centred on 560nm with a stock-shift in front of the first exciton absorption peak.
Published: 2012

27. A simple Tsumego Generator

Author: Chou, Ping-Chiang, Yen, Shi-Jim, Chou, Cheng-Wei, Lin, Ching-Nung, Lee, Chang-Shing, Teytaud, Olivier, Doghmen, Hassen, Go expert, Go Expert, National Dong Hwa University (NDHU), CSIE, NDHU, National Dong-Hwa University, OASE, Institute of Computer Science and Information Engineering [Taiwan] (Institute of CSIE), National Taiwan University [Taiwan] (NTU)-National Taiwan University [Taiwan] (NTU), Machine Learning and Optimisation (TAO), Laboratoire de Recherche en Informatique (LRI), Université Paris-Sud - Paris 11 (UP11)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria), Université Paris-Sud - Paris 11 (UP11)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS), indema, Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Université Paris-Sud - Paris 11 (UP11)-Laboratoire de Recherche en Informatique (LRI), and Université Paris-Sud - Paris 11 (UP11)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-CentraleSupélec
Subjects: ComputingMilieux_PERSONALCOMPUTING, [MATH.MATH-OC]Mathematics [math]/Optimization and Control [math.OC]
Abstract: International audience; Generating problems is an interesting challenge, for both pedagogical purpose and for assessment. We propose a simple solution for generating problems, which can be used on a wide range of games and simulators, and evaluate it in the framework of the game of Go, providing problems from lowest amateur range to problems which are not trivial even for professional players.
Published: 2012

28. Human vs. Computer Go Competition in FUZZ-IEEE 2011

Author: Chiu, Shih-Yuan, Doghmen, Hassen, Lee, Chang-Shing, Teytaud, Fabien, Teytaud, Olivier, Yen, Shi-Jim, CSIE, NDHU, National Dong-Hwa University, Machine Learning and Optimisation (TAO), Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Université Paris-Sud - Paris 11 (UP11)-Laboratoire de Recherche en Informatique (LRI), Université Paris-Sud - Paris 11 (UP11)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-CentraleSupélec, OASE, Institute of Computer Science and Information Engineering [Taiwan] (Institute of CSIE), National Taiwan University [Taiwan] (NTU)-National Taiwan University [Taiwan] (NTU), Université Paris-Sud - Paris 11 - Faculté des Sciences (UP11 UFR Sciences), Université Paris-Sud - Paris 11 (UP11), Laboratoire de Recherche en Informatique (LRI), Université Paris-Sud - Paris 11 (UP11)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS), National Dong Hwa University (NDHU), Université Paris-Sud - Paris 11 (UP11)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, and Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)
Subjects: [MATH.MATH-OC]Mathematics [math]/Optimization and Control [math.OC], ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2011

29. Anomalous attenuation of high-frequency seismic waves in Taiwan: observation, model and interpretation

Author: M. Calvet, L. Margerin, S.‐H. Hung, Institut de recherche en astrophysique et planétologie (IRAP), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), National Taiwan University [Taiwan] (NTU), and This research was supported by the International Joint Project for Scientific Corporation between CNRS, France and the Ministry of Science and Technology (MOST), Taiwan under the Grant CNRS-INSU PRC 2146 (LM and MC) and 107-2911-I-002-546- and 108-2911I-002-514- (SHH).
Subjects: Scattering, Fluids, Geophysics, Space and Planetary Science, Geochemistry and Petrology, [SDU.STU.GP]Sciences of the Universe [physics]/Earth Sciences/Geophysics [physics.geo-ph], Earth and Planetary Sciences (miscellaneous), Taiwan, Attenuation, Coda Waves, Crust, Absorption
Abstract: International audience; High resolution maps of seismic attenuation parameters in Taiwan have been obtained from a modified “Multiple Lapse Time Window Analysis” (MLTWA). At most of the stations in porous sedimentary and highly faulted areas in Taiwan, the conventional modeling of MLTWA based on the scalar theory of radiative transfer in a half-space with isotropic scattering fails to explain the spatio-temporal distribution of the whole S-wave train. Using Monte Carlo simulations of wave transport, we demonstrate that this anomalous energy distribution in the coda may be modeled by multiple anisotropic scattering of seismic waves. In addition to the scattering quality factor
Published: 2022

30. Split westerlies over Europe in the early Little Ice Age

Author: Hsun-Ming Hu, Chuan-Chou Shen, John C. H. Chiang, Valerie Trouet, Véronique Michel, Hsien-Chen Tsai, Patricia Valensi, Christoph Spötl, Elisabetta Starnini, Marta Zunino, Wei-Yi Chien, Wen-Hui Sung, Yu-Tang Chien, Ping Chang, Robert Korty, High-Precision Mass Spectrometry and Environment Change Laboratory (HISPEC), National Taiwan University [Taiwan] (NTU), Research Center for Future Earth, National Taiwan University, Department of geography, University of California, Laboratory of Tree-Ring Research [University of Arizona] (LTRR), University of Arizona, Culture et Environnements, Préhistoire, Antiquité, Moyen-Age (CEPAM), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Géoazur (GEOAZUR 7329), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Histoire naturelle de l'Homme préhistorique (HNHP), Muséum national d'Histoire naturelle (MNHN)-Université de Perpignan Via Domitia (UPVD)-Centre National de la Recherche Scientifique (CNRS), Fondation I.P.H, Institute of Geology, University of Innsbruck, University of Pisa - Università di Pisa, Archaeological Superintendency of Liguria, Toirano Cave, Piazzale D. Maineri 1, Toirano, National Science and Technology Center for Disaster Reduction (NCDR), and Texas A&M University, College Station, TX, 77843, USA
Subjects: Europe, Climate Action, Multidisciplinary, [SDU.STU.CL]Sciences of the Universe [physics]/Earth Sciences/Climatology, Arctic Regions, [SHS.ENVIR]Humanities and Social Sciences/Environmental studies, Climate, Climate Change, General Physics and Astronomy, Ice Cover, General Chemistry, General Biochemistry, Genetics and Molecular Biology, [SHS]Humanities and Social Sciences
Abstract: The Little Ice Age (LIA; ca. 1450–1850 C.E.) is the best documented cold period of the past millennium, characterized by high-frequency volcanism, low solar activity, and high variability of Arctic sea-ice cover. Past studies of LIA Atlantic circulation changes have referenced the North Atlantic Oscillation (NAO), but recent studies have noted that LIA climate patterns appear to possess complexity not captured by an NAO analogue. Here, we present a new precipitation-sensitive stalagmite record from northern Italy that covers the past 800 years. We show that in the early LIA (1470–1610 C.E.), increased atmospheric ridging over northern Europe split the climatological westerlies away from central and northern Europe, possibly caused by concurrent Artic sea-ice reduction. With ongoing ice melting in the northern high latitudes and decreasing solar irradiance in the coming years, the early LIA may potentially serve as an analogue for European hydroclimatic conditions in the coming decades.
Published: 2022

31. Assessing late Pliocene climate variability over glacial-interglacial timescales (PlioVAR)

Author: Erin McClymont, Sze Ling Ho, Heather Ford, Sarah White, Jeroen Groenveld, Clara Bolton, Kau Thirumalai, Georgia Grant, Molly Patterson, Montserrat Alonso-Garcia, Babette Hoogakker, Department of Geography, Durham University, Durham University, Institute of Oceanography [Taipei], National Taiwan University [Taiwan] (NTU), SCHOOL OF GEOGRAPHY QUEEN MARY UNIVERSITY OF LONDON GBR, Partenaires IRSTEA, Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Department of Earth and Planetary Sciences [Santa Cruz], University of California [Santa Cruz] (UC Santa Cruz), University of California (UC)-University of California (UC), Centre européen de recherche et d'enseignement des géosciences de l'environnement (CEREGE), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Collège de France (CdF (institution))-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Department of Geosciences [University of Arizona], University of Arizona, GNS Science [Lower Hutt], GNS Science, Department of Geological Sciences and Environmental Studies [Binghamton], Binghamton University [SUNY], and State University of New York (SUNY)-State University of New York (SUNY)
Subjects: [SDE]Environmental Sciences
Abstract: The Pliocene epoch (~2.6-5.3 million years ago) is one of the best resolved examples of a climate state in long-term equilibrium with current or predicted near-future atmospheric CO2 concentrations, characterised by a globally warmer climate, reduced continental ice volume, and reduced ocean/atmosphere circulation intensity compared to today. Towards the end of the Pliocene, there was a marked increase in glaciation in the northern hemisphere and atmospheric CO2 concentrations declined. The Past Global Changes (PAGES) PlioVAR working group aimed to co-ordinate a synthesis of terrestrial and marine data to characterise spatial and temporal variability of Pliocene climate, underpinned by high quality data sets supported by robust stratigraphies. Here we present some of the main findings of this synthesis effort, including new assessments of ocean temperatures during the KM5c interglacial, and recent work assessing orbital-scale climate variability across the late Pliocene-early Pleistocene northern hemisphere ice-sheet growth. We outline our approaches to integrating multi-proxy data recording ocean temperatures, d18O and sea-level variability from a globally distributed suite of marine sediment cores. We explore regional expressions of environmental change across this transition, identifying asynchronous trends and patterns in climate changes. We consider how these results might inform our understanding of past climate forcings and feedbacks during both warm intervals of the past and the development of larger ice sheets in the northern hemisphere.
Published: 2022

32. Stalagmite-inferred European westerly drift in the early Weichselian with centennial-scale variability in marine isotope stage 5a

Author: Yun-Chuan Chung, Laurie Menviel, Arianna Marchionne, Horng-Sheng Mii, Véronique Michel, Patricia Valensi, Xiuyang Jiang, Patrick Simon, Elena Rossoni-Notter, Abdelkader Moussous, Heikki Seppä, Yu-Tang Chien, Chung-Che Wu, Hsun-Ming Hu, Chuan-Chou Shen, CLIMATE CHANGE RESEARCH CENTRE SCHOOL OF BIOLOGICAL EARTH AND ENVIRONMENTAL SCIENCES UNIVERSITY OF NEW SOUTH WALES SYDNEY AUS, Partenaires IRSTEA, Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Department of Mathematics and Statistics [Helsinki], Falculty of Science [Helsinki], Helsingin yliopisto = Helsingfors universitet = University of Helsinki-Helsingin yliopisto = Helsingfors universitet = University of Helsinki, Department of Earth Sciences [NTNU Taipei], National Taiwan Normal University (NTNU), Culture et Environnements, Préhistoire, Antiquité, Moyen-Age (CEPAM), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Géoazur (GEOAZUR 7329), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), Histoire naturelle de l'Homme préhistorique (HNHP), Muséum national d'Histoire naturelle (MNHN)-Université de Perpignan Via Domitia (UPVD)-Centre National de la Recherche Scientifique (CNRS), Fujian Normal University [Fujian], Department of Geosciences and Geography [Helsinki], Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), High-Precision Mass Spectrometry and Environment Change Laboratory (HISPEC), and National Taiwan University [Taiwan] (NTU)
Subjects: Model simulation, Archeology, Global and Planetary Change, Southern Europe, Multi-centennial arid intervals, [SDU.STU.CL]Sciences of the Universe [physics]/Earth Sciences/Climatology, Weichselian, MIS 5a, AMOC, Geology, Precipitation, Stalagmite, Ecology, Evolution, Behavior and Systematics
Abstract: TheWeichselianglaciationis characterized by significant ocean circulation variations starting from ∼115 thousand years ago (ka) and terminating at ∼11.5 ka. The earlyWeichselian(115–74 ka), especiallymarine isotope stage(MIS) 5a at 85–74 ka, provides a window for understanding the linkage between the European westerlies andMediterranean climate. However, lack of highly-resolvedpaleoclimaterecords with absolute chronologies hampers our knowledge of decadal-to-centennial-scale climate changes and forcings in the circum-Mediterranean realm. Here, we present230Th-dated stalagmite-inferred hydroclimate records from Observatoire cave (43°44′ N, 7°25′E), Monaco, for the period between 88.7±0.4 and 80.3±0.1 ka, covering portions of MIS 5b and 5a. Agreement between Observatoire and circum-Mediterraneanstalagmiterecords confirm large-scale warming over the Atlantic-Europe territory during the transition from MIS 5b to 5a. Subdecadally-resolved Observatoire δ18O and δ13C records express four multi-centennial arid intervals in southern Europe at 84–80 ka in the first-half of MIS 5a, suggesting centennial westerly drifts, a finding supported by a model simulation. Westerly changes and associated arid events can be attributed to slowdowns of the Atlantic meridional overturning circulation,North Atlantic Oscillationstates, and solar activity.
Published: 2022
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33. Predicting attitudinal and behavioral responses to COVID-19 pandemic using machine learning

Author: Tomislav Pavlović, Flavio Azevedo, Koustav De, Julián C Riaño-Moreno, Marina Maglić, Theofilos Gkinopoulos, Patricio Andreas Donnelly-Kehoe, César Payán-Gómez, Guanxiong Huang, Jaroslaw Kantorowicz, Michèle D Birtel, Philipp Schönegger, Valerio Capraro, Hernando Santamaría-García, Meltem Yucel, Agustin Ibanez, Steve Rathje, Erik Wetter, Dragan Stanojević, Jan-Willem van Prooijen, Eugenia Hesse, Christian T Elbaek, Renata Franc, Zoran Pavlović, Panagiotis Mitkidis, Aleksandra Cichocka, Michele Gelfand, Mark Alfano, Robert M Ross, Hallgeir Sjåstad, John B Nezlek, Aleksandra Cislak, Patricia Lockwood, Koen Abts, Elena Agadullina, David M Amodio, Matthew A J Apps, John Jamir Benzon Aruta, Sahba Besharati, Alexander Bor, Becky Choma, William Cunningham, Waqas Ejaz, Harry Farmer, Andrej Findor, Biljana Gjoneska, Estrella Gualda, Toan L D Huynh, Mostak Ahamed Imran, Jacob Israelashvili, Elena Kantorowicz-Reznichenko, André Krouwel, Yordan Kutiyski, Michael Laakasuo, Claus Lamm, Jonathan Levy, Caroline Leygue, Ming-Jen Lin, Mohammad Sabbir Mansoor, Antoine Marie, Lewend Mayiwar, Honorata Mazepus, Cillian McHugh, Andreas Olsson, Tobias Otterbring, Dominic Packer, Jussi Palomäki, Anat Perry, Michael Bang Petersen, Arathy Puthillam, Tobias Rothmund, Petra C Schmid, David Stadelmann, Augustin Stoica, Drozdstoy Stoyanov, Kristina Stoyanova, Shruti Tewari, Bojan Todosijević, Benno Torgler, Manos Tsakiris, Hans H Tung, Radu Gabriel Umbreș, Edmunds Vanags, Madalina Vlasceanu, Andrew J Vonasch, Yucheng Zhang, Mohcine Abad, Eli Adler, Hamza Alaoui Mdarhri, Benedict Antazo, F Ceren Ay, Mouhamadou El Hady Ba, Sergio Barbosa, Brock Bastian, Anton Berg, Michał Białek, Ennio Bilancini, Natalia Bogatyreva, Leonardo Boncinelli, Jonathan E Booth, Sylvie Borau, Ondrej Buchel, Chrissie Ferreira de Carvalho, Tatiana Celadin, Chiara Cerami, Hom Nath Chalise, Xiaojun Cheng, Luca Cian, Kate Cockcroft, Jane Conway, Mateo A Córdoba-Delgado, Chiara Crespi, Marie Crouzevialle, Jo Cutler, Marzena Cypryańska, Justyna Dabrowska, Victoria H Davis, John Paul Minda, Pamala N Dayley, Sylvain Delouvée, Ognjan Denkovski, Guillaume Dezecache, Nathan A Dhaliwal, Alelie Diato, Roberto Di Paolo, Uwe Dulleck, Jānis Ekmanis, Tom W Etienne, Hapsa Hossain Farhana, Fahima Farkhari, Kristijan Fidanovski, Terry Flew, Shona Fraser, Raymond Boadi Frempong, Jonathan Fugelsang, Jessica Gale, E Begoña García-Navarro, Prasad Garladinne, Kurt Gray, Siobhán M Griffin, Bjarki Gronfeldt, June Gruber, Eran Halperin, Volo Herzon, Matej Hruška, Matthias F C Hudecek, Ozan Isler, Simon Jangard, Frederik Jørgensen, Oleksandra Keudel, Lina Koppel, Mika Koverola, Anton Kunnari, Josh Leota, Eva Lermer, Chunyun Li, Chiara Longoni, Darragh McCashin, Igor Mikloušić, Juliana Molina-Paredes, César Monroy-Fonseca, Elena Morales-Marente, David Moreau, Rafał Muda, Annalisa Myer, Kyle Nash, Jonas P Nitschke, Matthew S Nurse, Victoria Oldemburgo de Mello, M Soledad Palacios-Galvez, Yafeng Pan, Zsófia Papp, Philip Pärnamets, Mariola Paruzel-Czachura, Silva Perander, Michael Pitman, Ali Raza, Gabriel Gaudencio Rêgo, Claire Robertson, Iván Rodríguez-Pascual, Teemu Saikkonen, Octavio Salvador-Ginez, Waldir M Sampaio, Gaia Chiara Santi, David Schultner, Enid Schutte, Andy Scott, Ahmed Skali, Anna Stefaniak, Anni Sternisko, Brent Strickland, Jeffrey P Thomas, Gustav Tinghög, Iris J Traast, Raffaele Tucciarelli, Michael Tyrala, Nick D Ungson, Mete Sefa Uysal, Dirk Van Rooy, Daniel Västfjäll, Joana B Vieira, Christian von Sikorski, Alexander C Walker, Jennifer Watermeyer, Robin Willardt, Michael J A Wohl, Adrian Dominik Wójcik, Kaidi Wu, Yuki Yamada, Onurcan Yilmaz, Kumar Yogeeswaran, Carolin-Theresa Ziemer, Rolf A Zwaan, Paulo Sergio Boggio, Ashley Whillans, Paul A M Van Lange, Rajib Prasad, Michal Onderco, Cathal O'Madagain, Tarik Nesh-Nash, Oscar Moreda Laguna, Emily Kubin, Mert Gümren, Ali Fenwick, Arhan S Ertan, Michael J Bernstein, Hanane Amara, Jay Joseph Van Bavel, Brain and Cognition, Public Administration, Pavlovic, Tomislav, Avezedo, Flávio, De, Koustav, Maglić, Marina, Donnelly-Kehoe, Patricio Andreas, Payán-Gómez, César, Van Bavel, Jay J., Schmid, Petra Claudia, Crouzevialle, Marie, Willardt, Robin, et al., Ivo Pilar Institute of Social Sciences, University of Cambridge [UK] (CAM), University of Kentucky (UK), Universidad El Bosque [Bogota], University of Crete [Heraklion] (UOC), Universidad del Rosario [Bogota], Universidad Nacional de Colombia [Bogotà] (UNAL), City University of Hong Kong [Hong Kong] (CUHK), Universiteit Leiden, University of Greenwich, University of St Andrews [Scotland], Middlesex University [London], Pontifical Xavierian University, Duke University [Durham], Universidad Adolfo Ibáñez [Santiago], University of California (UC), Trinity College Dublin, Stockholm School of Economics (SSE), University of Belgrade [Belgrade], Vrije Universiteit Amsterdam [Amsterdam] (VU), Universidad Mayor de San Andrés (UMSA), Aarhus University [Aarhus], University of Kent [Canterbury], Stanford University, Macquarie University, Norwegian School of Economics and Business Administration, SWPS University of Social Sciences and Humanities (SWPS), University of Birmingham [Birmingham], University of Oxford, Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Vysšaja škola èkonomiki = National Research University Higher School of Economics [Moscow] (HSE), University of Amsterdam [Amsterdam] (UvA), Sunway University [Malaysia], University of the Witwatersrand [Johannesburg] (WITS), University of Toronto, National University of Sciences and Technology [Islamabad] (NUST), Comenius University in Bratislava, Macedonian Academy of Sciences and Arts [Skopje, North Macedonia] (MASA), Universidad de Huelva, University of Southampton, BRAC University, The Hebrew University of Jerusalem (HUJ), Erasmus University Rotterdam, Kieskompas, Helsingin yliopisto = Helsingfors universitet = University of Helsinki, University of Vienna [Vienna], Reichman University [Herzliya], Aalto University, Universidad Nacional Autónoma de México = National Autonomous University of Mexico (UNAM), National Taiwan University [Taiwan] (NTU), HEMS School, BI Norwegian Business School [Oslo], University of Limerick (UL), Karolinska Institutet [Stockholm], University of Agder (UIA), Lehigh University [Bethlehem], Monk Prayogshala, Friedrich-Schiller-Universität = Friedrich Schiller University Jena [Jena, Germany], Eidgenössische Technische Hochschule Zürich - Swiss Federal Institute of Technology in Zürich (ETH Zurïch), University of Bayreuth, National School of Political and Administrative Studies (SNSPA), Plovdiv University 'Paisii Hilendarski', Indian Institute of Management Indore (IMM Indore), Institute of Social Sciences Belgrade, Queensland University of Technology [Brisbane] (QUT), Royal Holloway [University of London] (RHUL), University of London [London], National University of Political Studies and Public Administration, University of Latvia (LU), New York University [New York] (NYU), NYU System (NYU), University of Canterbury [Christchurch], Hebei University of Technology [Tianjin], Université Mohammed VI Polytechnique [Ben Guerir] (UM6P), AnsuR Technologies [Fornebu], Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD), Victoria University [Melbourne], University of Wrocław [Poland] (UWr), IMT Institute for Advanced Studies [Lucca], Université de Florence, Università degli Studi di Firenze = University of Florence (UniFI), London School of Economics and Political Science (LSE), TBS Education, Slovak Academy of Science [Bratislava] (SAS), Santa Catarina State University (UDESC), University of Bologna/Università di Bologna, Tribhuvan University, Shenzhen Univerisity [Shenzhen], University of Virginia, Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT), University of Western Ontario (UWO), Université de Rennes 2 (UR2), Laboratoire de Psychologie Sociale et Cognitive (LAPSCO), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), University of British Columbia (UBC), University of Queensland [Brisbane], Pennsylvania State University (Penn State), Penn State System, Westfälische Wilhelms-Universität Münster = University of Münster (WWU), The University of Sydney, University of Waterloo [Waterloo], University of North Carolina [Chapel Hill] (UNC), University of North Carolina System (UNC), University of Colorado [Boulder], University of Regensburg, Kyiv School of economic (KSE), Linköping University (LIU), Monash University [Clayton], Ansbach University of Applied Sciences, Ludwig Maximilian University [Munich] (LMU), Department of Management - London School of Economics and Political Science (LSE), Questrom School of Business, Boston University [Boston] (BU), Dublin City University [Dublin] (DCU), University of Auckland [Auckland], Maria Curie-Sklodowska University (UMCS), City University of New York [New York] (CUNY), University of Alberta, Australian National University (ANU), University of Silesia in Katowice, Universidad Complutense de Madrid = Complutense University of Madrid [Madrid] (UCM), Zhejiang University, Mackenzie Presbyterian University [São Paulo] (UPM), NYU Department of Psychology [New-York University], NYU System (NYU)-NYU System (NYU), University of Turku, City College of New York [CUNY] (CCNY), University of Groningen [Groningen], Carleton University, Département d'Etudes Cognitives - ENS Paris (DEC), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Faculté de Gouvernance, Sciences Économiques et Sociales [UM6P] (FGSES), University College of London [London] (UCL), Susquehanna University, University of Antwerp (UA), University of Exeter, University of Koblenz-Landau, Nicolaus Copernicus University [Toruń], University of California [San Diego] (UC San Diego), Kyushu University, Kadir Has University (KHAS), Harvard Business School, Harvard University, Vidyasagar College For Women, Koç University, Hult International Business School, Boǧaziçi üniversitesi = Boğaziçi University [Istanbul], Penn State Abington, Pennsylvania Commonwealth System of Higher Education (PCSHE)-Penn State System, Communication Science, Network Institute, Communication Choices, Content and Consequences (CCCC), Social Psychology, IBBA, A-LAB, University of St Andrews. Philosophy, University of St Andrews. School of Psychology and Neuroscience, Pavlović, Tomislav [0000-0002-4470-3715], Azevedo, Flavio [0000-0001-9000-8513], De, Koustav [0000-0001-9562-0672], Riaño-Moreno, Julián C [0000-0003-4182-0550], Maglić, Marina [0000-0002-6851-4601], Gkinopoulos, Theofilos [0000-0003-1070-6245], Donnelly-Kehoe, Patricio Andreas [0000-0002-3738-9537], Payán-Gómez, César [0000-0002-0633-1332], Huang, Guanxiong [0000-0002-8588-1454], Kantorowicz, Jaroslaw [0000-0002-1186-5427], Birtel, Michèle D [0000-0002-2383-9197], Schönegger, Philipp [0000-0001-9930-487X], Capraro, Valerio [0000-0002-0579-0166], Santamaría-García, Hernando [0000-0001-9422-3579], Yucel, Meltem [0000-0002-7274-5971], Ibanez, Agustin [0000-0001-6758-5101], Rathje, Steve [0000-0001-6727-571X], Wetter, Erik [0000-0002-5821-6651], Stanojević, Dragan [0000-0002-3667-2461], van Prooijen, Jan-Willem [0000-0001-6236-0819], Hesse, Eugenia [0000-0002-9077-9833], Elbaek, Christian T [0000-0002-7039-4565], Franc, Renata [0000-0002-1909-2393], Pavlović, Zoran [0000-0002-9231-5100], Mitkidis, Panagiotis [0000-0002-9495-7369], Cichocka, Aleksandra [0000-0003-1703-1586], Alfano, Mark [0000-0001-5879-8033], Ross, Robert M [0000-0001-8711-1675], Sjåstad, Hallgeir [0000-0002-8730-1038], Nezlek, John B [0000-0003-4963-3637], Cislak, Aleksandra [0000-0002-9880-6947], Lockwood, Patricia [0000-0001-7195-9559], Abts, Koen [0000-0001-8546-8347], Agadullina, Elena [0000-0002-1505-1412], Amodio, David M [0000-0001-7746-0150], Apps, Matthew AJ [0000-0001-5793-2202], Aruta, John Jamir Benzon [0000-0003-4155-1063], Besharati, Sahba [0000-0003-2836-7982], Bor, Alexander [0000-0002-2624-9221], Choma, Becky [0000-0002-8286-8983], Ejaz, Waqas [0000-0002-2492-4115], Farmer, Harry [0000-0002-3684-0605], Findor, Andrej [0000-0002-5896-6989], Gjoneska, Biljana [0000-0003-1200-6672], Gualda, Estrella [0000-0003-0220-2135], Huynh, Toan LD [0000-0002-6653-7447], Imran, Mostak Ahamed [0000-0002-5101-3149], Israelashvili, Jacob [0000-0003-1289-223X], Kantorowicz-Reznichenko, Elena [0000-0001-8128-7290], Krouwel, André [0000-0003-0952-6028], Kutiyski, Yordan [0000-0003-0889-4232], Laakasuo, Michael [0000-0003-2826-6073], Lamm, Claus [0000-0002-5422-0653], Levy, Jonathan [0000-0003-1007-2393], Leygue, Caroline [0000-0002-0355-1030], Lin, Ming-Jen [0000-0002-7174-2226], Mansoor, Mohammad Sabbir [0000-0002-6541-3506], Marie, Antoine [0000-0002-7958-0153], Mayiwar, Lewend [0000-0003-1404-4779], Mazepus, Honorata [0000-0002-5005-9399], McHugh, Cillian [0000-0002-9701-3232], Olsson, Andreas [0000-0001-5272-7744], Otterbring, Tobias [0000-0002-0283-8777], Packer, Dominic [0000-0001-8420-6548], Palomäki, Jussi [0000-0001-6063-0926], Perry, Anat [0000-0003-2329-856X], Petersen, Michael Bang [0000-0002-6782-5635], Puthillam, Arathy [0000-0003-2426-8362], Rothmund, Tobias [0000-0003-2979-5129], Schmid, Petra C [0000-0002-9990-5445], Stadelmann, David [0000-0002-1211-9936], Stoica, Augustin [0000-0003-0585-1114], Stoyanov, Drozdstoy [0000-0002-9975-3680], Stoyanova, Kristina [0000-0001-8362-6444], Tewari, Shruti [0000-0003-1903-7252], Todosijević, Bojan [0000-0002-6116-993X], Torgler, Benno [0000-0002-9809-963X], Tsakiris, Manos [0000-0001-7753-7576], Tung, Hans H [0000-0001-5332-7582], Umbreș, Radu Gabriel [0000-0002-6121-4518], Vanags, Edmunds [0000-0003-1932-936X], Vlasceanu, Madalina [0000-0003-2138-1968], Vonasch, Andrew J [0000-0002-2784-5420], Zhang, Yucheng [0000-0001-9435-6734], Abad, Mohcine [0000-0002-4964-5411], Adler, Eli [0000-0002-9005-5536], Mdarhri, Hamza Alaoui [0000-0001-9831-6561], Antazo, Benedict [0000-0001-9993-8960], Ay, F Ceren [0000-0003-4444-2268], Ba, Mouhamadou El Hady [0000-0002-2707-1242], Barbosa, Sergio [0000-0003-1989-158X], Bastian, Brock [0000-0003-4619-3322], Berg, Anton [0000-0001-7143-762X], Białek, Michał [0000-0002-5062-5733], Bilancini, Ennio [0000-0002-2027-3992], Bogatyreva, Natalia [0000-0002-6024-2322], Boncinelli, Leonardo [0000-0003-0626-5133], Booth, Jonathan E [0000-0002-8563-4613], Borau, Sylvie [0000-0003-1564-0695], Buchel, Ondrej [0000-0002-0139-5513], de Carvalho, Chrissie Ferreira [0000-0002-1369-6188], Celadin, Tatiana [0000-0002-7743-3117], Cerami, Chiara [0000-0003-1974-3421], Chalise, Hom Nath [0000-0002-9301-6890], Cian, Luca [0000-0002-8051-1366], Cockcroft, Kate [0000-0002-6166-8050], Conway, Jane [0000-0003-3883-349X], Córdoba-Delgado, Mateo A [0000-0002-2264-7388], Crespi, Chiara [0000-0002-7851-9887], Crouzevialle, Marie [0000-0002-5538-6030], Cutler, Jo [0000-0003-1073-764X], Cypryańska, Marzena [0000-0001-9234-562X], Dabrowska, Justyna [0000-0002-8821-7161], Davis, Victoria H [0000-0002-7207-4629], Minda, John Paul [0000-0002-4081-010X], Dayley, Pamala N [0000-0001-8955-9502], Delouvée, Sylvain [0000-0002-4029-597X], Denkovski, Ognjan [0000-0002-9739-4100], Dezecache, Guillaume [0000-0002-9366-6287], Dhaliwal, Nathan A [0000-0002-4667-0689], Di Paolo, Roberto [0000-0002-6081-6656], Dulleck, Uwe [0000-0002-0953-5963], Ekmanis, Jānis [0000-0003-1781-1785], Etienne, Tom W [0000-0002-4299-6593], Farkhari, Fahima [0000-0002-8484-5128], Fidanovski, Kristijan [0000-0002-9006-0140], Flew, Terry [0000-0003-4485-9338], Fraser, Shona [0000-0003-1505-0652], Frempong, Raymond Boadi [0000-0002-4603-5570], Fugelsang, Jonathan [0000-0002-6342-7023], Gale, Jessica [0000-0001-5677-8629], García-Navarro, E Begoña [0000-0001-6913-8882], Gray, Kurt [0000-0001-5816-2676], Griffin, Siobhán M [0000-0002-3613-2844], Gronfeldt, Bjarki [0000-0001-9941-7903], Gruber, June [0000-0002-7789-1353], Halperin, Eran [0000-0002-3379-2935], Herzon, Volo [0000-0001-7781-1651], Hruška, Matej [0000-0002-4521-3697], Hudecek, Matthias FC [0000-0002-7696-766X], Isler, Ozan [0000-0002-4638-2230], Jangard, Simon [0000-0002-7876-4161], Jørgensen, Frederik [0000-0002-5461-912X], Keudel, Oleksandra [0000-0001-6322-3103], Koppel, Lina [0000-0002-6302-0047], Koverola, Mika [0000-0001-8227-6120], Kunnari, Anton [0000-0002-2951-6399], Leota, Josh [0000-0002-7714-4630], Lermer, Eva [0000-0002-6600-9580], Li, Chunyun [0000-0001-5909-0889], Longoni, Chiara [0000-0002-4945-4957], McCashin, Darragh [0000-0003-2686-2111], Mikloušić, Igor [0000-0002-6539-2901], Monroy-Fonseca, César [0000-0003-4696-8159], Morales-Marente, Elena [0000-0002-1227-9606], Moreau, David [0000-0002-1957-1941], Muda, Rafał [0000-0003-4953-6642], Myer, Annalisa [0000-0002-2363-4757], Nash, Kyle [0000-0003-0461-3835], Nitschke, Jonas P [0000-0002-3244-8585], Nurse, Matthew S [0000-0003-1787-5914], de Mello, Victoria Oldemburgo [0000-0003-2867-8529], Palacios-Galvez, Maria Soledad [0000-0002-6802-6202], Pan, Yafeng [0000-0002-5633-8313], Papp, Zsófia [0000-0001-6257-0568], Pärnamets, Philip [0000-0001-8360-9097], Paruzel-Czachura, Mariola [0000-0002-8716-9778], Perander, Silva [0000-0001-6711-8079], Pitman, Michael [0000-0001-5532-5388], Raza, Ali [0000-0002-2438-6054], Rêgo, Gabriel Gaudencio [0000-0003-3304-4723], Robertson, Claire [0000-0001-8403-6358], Rodríguez-Pascual, Iván [0000-0002-5385-3643], Saikkonen, Teemu [0000-0001-9619-3270], Salvador-Ginez, Octavio [0000-0002-1652-8788], Sampaio, Waldir M [0000-0002-6066-4314], Santi, Gaia Chiara [0000-0002-9253-6122], Schultner, David [0000-0003-2253-4065], Schutte, Enid [0000-0002-6653-5409], Scott, Andy [0000-0002-3294-0078], Skali, Ahmed [0000-0002-4753-3280], Stefaniak, Anna [0000-0002-1706-7784], Sternisko, Anni [0000-0002-2507-3076], Strickland, Brent [0000-0002-7573-3722], Thomas, Jeffrey P [0000-0002-5939-5559], Tinghög, Gustav [0000-0002-8159-1249], Tucciarelli, Raffaele [0000-0002-0342-308X], Tyrala, Michael [0000-0001-5268-8319], Ungson, Nick D [0000-0003-2494-4498], Uysal, Mete Sefa [0000-0002-8698-9213], Van Rooy, Dirk [0000-0003-2525-5408], Västfjäll, Daniel [0000-0003-2873-4500], Vieira, Joana B [0000-0001-7335-4588], von Sikorski, Christian [0000-0002-3787-8277], Walker, Alexander C [0000-0003-1431-6770], Watermeyer, Jennifer [0000-0001-7918-8832], Willardt, Robin [0000-0002-2495-3450], Wohl, Michael JA [0000-0001-6945-5562], Wójcik, Adrian Dominik [0000-0002-7073-6019], Wu, Kaidi [0000-0001-6881-7437], Yamada, Yuki [0000-0003-1431-568X], Yilmaz, Onurcan [0000-0002-6094-7162], Yogeeswaran, Kumar [0000-0002-1978-5077], Ziemer, Carolin-Theresa [0000-0002-0794-7702], Zwaan, Rolf A [0000-0001-9967-7879], Boggio, Paulo Sergio [0000-0002-6109-0447], Van Lange, Paul AM [0000-0001-7774-6984], Prasad, Rajib [0000-0003-0913-1624], Onderco, Michal [0000-0001-9911-3782], O'Madagain, Cathal [0000-0002-4086-524X], Nesh-Nash, Tarik [0000-0002-5532-9095], Kubin, Emily [0000-0003-0606-8594], Gümren, Mert [0000-0002-3298-6295], Fenwick, Ali [0000-0002-5412-9745], Ertan, Arhan S [0000-0001-9730-8391], Bernstein, Michael J [0000-0002-8083-9839], Amara, Hanane [0000-0003-0732-2320], Van Bavel, Jay Joseph [0000-0002-2520-0442], Apollo - University of Cambridge Repository, Sociale Psychologie (Psychologie, FMG), ASCoR Other Research (FMG), Department of Neuroscience and Biomedical Engineering, Aalto-yliopisto, Department of Digital Humanities, Department of Psychology and Logopedics, Cognitive Science, High Performance Cognition group, Mind and Matter, and Department of Computer Science
Subjects: Hälso- och sjukvårdsorganisation, hälsopolitik och hälsoekonomi, Economics, COVID-19, social distancing, hygiene, policy support, public health measures, J Political Science, [SHS.PSY]Humanities and Social Sciences/Psychology, psychology, Settore SECS-P/02 - Politica Economica, Q1, H Social Sciences, [STAT.ML]Statistics [stat]/Machine Learning [stat.ML], SDG 3 - Good Health and Well-being, RA0421, RA0421 Public health. Hygiene. Preventive Medicine, Machine learning, Psychology, Nationalekonomi, Settore SECS-P/01 - Economia Politica, MCC, Computer. Automation, Psykologi (exklusive tillämpad psykologi), DAS, Health Care Service and Management, Health Policy and Services and Health Economy, [SHS.SCIPO]Humanities and Social Sciences/Political science, Psychology (excluding Applied Psychology), machine learning, Settore SECS-P/03 - Scienza delle Finanze, 5171 Political Science, Human medicine, COVID-19, social distancing, hygiene, policy support, public health measures
Abstract: At the beginning of 2020, COVID-19 became a global problem. Despite all the efforts to emphasize the relevance of preventive measures, not everyone adhered to them. Thus, learning more about the characteristics determining attitudinal and behavioral responses to the pandemic is crucial to improving future interventions. In this study, we applied machine learning on the multinational data collected by the International Collaboration on the Social and Moral Psychology of COVID-19 (N = 51,404) to test the predictive efficacy of constructs from social, moral, cognitive, and personality psychology, as well as socio-demographic factors, in the attitudinal and behavioral responses to the pandemic. The results point to several valuable insights. Internalized moral identity provided the most consistent predictive contribution—individuals perceiving moral traits as central to their self-concept reported higher adherence to preventive measures. Similar results were found for morality as cooperation, symbolized moral identity, self-control, open-mindedness, and collective narcissism, while the inverse relationship was evident for the endorsement of conspiracy theories. However, we also found a non-neglible variability in the explained variance and predictive contributions with respect to macro-level factors such as the pandemic stage or cultural region. Overall, the results underscore the importance of morality-related and contextual factors in understanding adherence to public health recommendations during the pandemic., PNAS Nexus, 1 (3), ISSN:2752-6542
Published: 2022

34. Serial crystallography captures dynamic control of sequential electron and proton transfer events in a flavoenzyme

Author: Manuel Maestre-Reyna, Cheng-Han Yang, Eriko Nango, Wei-Cheng Huang, Eka Putra Gusti Ngurah Putu, Wen-Jin Wu, Po-Hsun Wang, Sophie Franz-Badur, Martin Saft, Hans-Joachim Emmerich, Hsiang-Yi Wu, Cheng-Chung Lee, Kai-Fa Huang, Yao-Kai Chang, Jiahn-Haur Liao, Jui-Hung Weng, Wael Gad, Chiung-Wen Chang, Allan H. Pang, Michihiro Sugahara, Shigeki Owada, Yuhei Hosokawa, Yasumasa Joti, Ayumi Yamashita, Rie Tanaka, Tomoyuki Tanaka, Fangjia Luo, Kensuke Tono, Kai-Cheng Hsu, Stephan Kiontke, Igor Schapiro, Roberta Spadaccini, Antoine Royant, Junpei Yamamoto, So Iwata, Lars-Oliver Essen, Yoshitaka Bessho, Ming-Daw Tsai, Academia Sinica, RIKEN - Institute of Physical and Chemical Research [Japon] (RIKEN), Philipps Universität Marburg = Philipps University of Marburg, Thin Film Technology Center, National Central University [Taiwan] (NCU), Japan Synchrotron Radiation Research Institute [Hyogo] (JASRI), Graduate School of Engineering Science [Toyonaka, Osaka], Osaka University, Taipei Medical University, The Fritz Haber Research Center for Molecular Dynamics [Jerusalem], The Hebrew University of Jerusalem (HUJ), Università degli Studi del Sannio, Institut de biologie structurale (IBS - UMR 5075), Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche Interdisciplinaire de Grenoble (IRIG), Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Grenoble Alpes (UGA), European Synchroton Radiation Facility [Grenoble] (ESRF), RIKEN SPring-8 Center [Hyogo] (RIKEN RSC), National Taiwan University [Taiwan] (NTU), and ANR-17-EURE-0003,CBH-EUR-GS,CBH-EUR-GS(2017)
Subjects: MESH: Oxidation-Reduction, MESH: Electrons, Crystallography, [SDV.BBM.BS]Life Sciences [q-bio]/Biochemistry, Molecular Biology/Structural Biology [q-bio.BM], General Chemical Engineering, MESH: Crystallography, MESH: Arginine, Electrons, General Chemistry, Arginine, Electron Transport, MESH: Deoxyribodipyrimidine Photo-Lyase, MESH: Flavin-Adenine Dinucleotide, Flavins, Flavin-Adenine Dinucleotide, MESH: Protons, Protons, MESH: Electron Transport, MESH: Flavins, Deoxyribodipyrimidine Photo-Lyase, Oxidation-Reduction
Abstract: International audience; Flavin coenzymes are universally found in biological redox reactions. DNA photolyases, with their flavin chromophore (FAD), utilize blue light for DNA repair and photoreduction. The latter process involves two single-electron transfers to FAD with an intermittent protonation step to prime the enzyme active for DNA repair. Here we use time-resolved serial femtosecond X-ray crystallography to describe how light-driven electron transfers trigger subsequent nanosecond-to-microsecond entanglement between FAD and its Asn/Arg-Asp redox sensor triad. We found that this key feature within the photolyase-cryptochrome family regulates FAD re-hybridization and protonation. After first electron transfer, the FAD•- isoalloxazine ring twists strongly when the arginine closes in to stabilize the negative charge. Subsequent breakage of the arginine-aspartate salt bridge allows proton transfer from arginine to FAD•-. Our molecular videos demonstrate how the protein environment of redox cofactors organizes multiple electron/proton transfer events in an ordered fashion, which could be applicable to other redox systems such as photosynthesis.
Published: 2022

35. The design of artificial nestboxes for the study of secondary hole-nesting birds: A review of methodological inconsistencies and potential biases

Author: Jean Charles Bouvier, Martyn J. Stenning, Caren B. Cooper, Chan Ryul Park, Christopher M. Perrins, Tapio Eeva, Marcel M. Lambrechts, Beat Naef-Daenzer, Emilio Barba, Bengt Silverin, Henrik G. Smith, Arie J. van Noordwijk, L. Scott Johnson, Jordi Camprodon, Anders Pape Møller, Charles F. Thompson, Paulo E. Llambías, Anne E. Goodenough, Oskars Keišs, Bruno Faivre, Jaime Potti, Jan Ke Nilsson, Francisco Atiénzar, Nadia Ziane, Jerzy Bańbura, Alberto Sorace, Tore Slagsvold, Daniel R. Ardia, Arnaud Grégoire, Simon C. Griffith, Lars Gustafsson, Frank Adriaensen, János Török, Marcel Eens, Markku Orell, Alexandr Artemyev, Heinz Richner, Jan Pinowski, Andrew G. Gosler, Ian R. K. Stewart, Vladimír Remeš, Juan Moreno, Jiri Porkert, Seppo Rytkönen, Tomasz D. Mazgajski, David W. Winkler, Bruno Massa, Russell D. Dawson, Ken A. Otter, Ming Tang Shiao, László Zsolt Garamszegi, Piotr Tryjanowski, Wojciech Kania, Mark C. Mainwaring, Raivo Mänd, Ana Cláudia Norte, Animal Ecology (AnE), Centre d’Ecologie Fonctionnelle et Evolutive (CEFE), Université Paul-Valéry - Montpellier 3 (UM3)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-École pratique des hautes études (EPHE)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud])-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Evolutionary Ecology Group, University of Antwerp (UA), Department of Biology, Franklin & Marshall College, Institute of Biology, Russian Academy of Sciences [Moscow] (RAS), Terrestrial Vertebrates Research Unit 'Cavanilles', University of Valencia-Institute of Biodiversity and Evolutionary Biology, Department of Experimental Zoology & Evolutionary Biology, Łódź University of Technology, Unité de recherche Plantes et Systèmes de Culture Horticoles (PSH), Institut National de la Recherche Agronomique (INRA), Biodiversity Department, Forest Technology Center of Catalonia, Cornell Laboratory of Ornithology, Cornell University, Ecosystem Science and Management Program, University of Northern British Columbia (UNBC), Department of Biology (Ethology), Section of Ecology, University of Turku, Biogéosciences [UMR 6282] [Dijon] (BGS), Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique (CNRS), Department of Evolutionary Ecology, Estacion Biologica de Donana, Department of Natural and Social Sciences, University of Gloucestershire, Department of Zoology, Edward Grey Institute of Field Ornithology-Institute of Human Sciences, Department of Brain, Behaviour and Evolution, Macquarie University, Evolutionary Biology Centre, Uppsala University, Towson University [Towson, MD, United States], University of Maryland System-University of Maryland System, Ornithological Station, Polska Akademia Nauk (PAN)-Museum and Institute of Zoology, Laboratory of Ornithology, University of Latvia (LU), Ecologia del Comportamiento Animal, Consejo Nacional de Investigaciones Científicas y Técnicas [Buenos Aires] (CONICET), Lancaster Environment Centre, Lancaster University, University of Tartu, Stazione Inanellamento c/o Dipartimento SEN-FIMIZO, Università di Palermo, Museum and Institute of Zoology, Polska Akademia Nauk (PAN), Ecologie Systématique et Evolution (ESE), Université Paris-Sud - Paris 11 (UP11)-AgroParisTech-Centre National de la Recherche Scientifique (CNRS), Center for Advanced Study, Departamento de Ecología Evolutiva, Consejo Superior de Investigaciones Científicas [Spain] (CSIC)-Museo Nacional de Ciencias Naturales (MNCN), Swiss Ornithological Institute, Animal Ecology, Lund University [Lund], Department of Life Sciences, University of Coimbra [Portugal] (UC), University of Oulu, Warm-temperate Forest Research Center, Korea Forest Research Institute, Center of Ecological Research, Palacky University, Institute of Ecology & Evolution (IEE), University of Bern, Wildlife laboratory, National Taiwan University [Taiwan] (NTU), University of Gothenburg (GU), Department of Biosciences [Oslo], Faculty of Mathematics and Natural Sciences [Oslo], University of Oslo (UiO)-University of Oslo (UiO), School of Life Sciences, University of Sussex, University of Kentucky, Behavior, Ecology, Evolution, and Systematics Section, Illinois State University, Behavioural Ecology Group, Eötvös Loránd University (ELTE), Institute of Zoology, Poznan University of Life Sciences, Netherlands Institute of Ecology, Laboratory of Ornithology and Department of Ecology & Evolutionary Biology, Laboratoire d'Ecophysiologie animale, Département de Biologie, Lambrechts, M M, Adriaensen, F, Ardia, D R, Artemyev, A V, Atiénzar, F, Bańbura, J, Barba, E, Bouvier, J-C, Camprodon, J, Cooper, C B, Dawson, R D, Eens, M, Eeva, T, Faivre, B, Garamszegi, L Z, Goodenough, A E, Gosler, A G, Grégoire, A, Griffith, S C, Gustafsson, L, Johnson, L S, Kania, W, Keišs, O, Llambias, P E, Mainwaring, M C, Mänd, R, Massa, B, Mazgajski, T D, Møller, A P, Moreno, J, Naef-Daenzer, B, Nilsson, J-C, Norte, A C, Orell, M, Otter, K A, Park, Ch R, Perrins, Ch M, Pinowski, J, Porkert, J, Potti, J, Remes, V, Richner, H, Rytkönen, S, Shiao, M-T, Silverin, B, Slagsvold, T, Smith, H G, Sorace, A, Stenning, M J, Stewart, I, Thompson, Ch F, Török, J, Tryjanowski, P, van Noordwijk, A J, Winkler, D W, Ziane, N, Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut National de la Recherche Agronomique (INRA)-Université Paul-Valéry - Montpellier 3 (UPVM)-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut de Recherche pour le Développement (IRD [France-Sud]), Centre de Ciència i Tecnologia Forestal de Catalunya (CTFC), Cornell University [New York], University of Northern British Columbia [Prince George] (UNBC), Centre National de la Recherche Scientifique (CNRS)-Université de Bourgogne (UB)-AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement, Estación Biológica de Doñana (EBD), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Consejo Superior de Investigaciones Científicas [Madrid] (CSIC), Polska Akademia Nauk = Polish Academy of Sciences (PAN)-Museum and Institute of Zoology, Polska Akademia Nauk = Polish Academy of Sciences (PAN), Consejo Superior de Investigaciones Científicas [Madrid] (CSIC)-Museo Nacional de Ciencias Naturales (MNCN), Palacky University Olomouc, Centre d’Ecologie Fonctionnelle et Evolutive ( CEFE ), Université Paul-Valéry - Montpellier 3 ( UM3 ) -Centre international d'études supérieures en sciences agronomiques ( Montpellier SupAgro ) -École pratique des hautes études ( EPHE ) -Institut national de la recherche agronomique [Montpellier] ( INRA Montpellier ) -Université de Montpellier ( UM ) -Centre National de la Recherche Scientifique ( CNRS ) -Institut de Recherche pour le Développement ( IRD [France-Sud] ) -Institut national d’études supérieures agronomiques de Montpellier ( Montpellier SupAgro ), University of Antwerp ( UA ), Russian Academy of Sciences [Moscow] ( RAS ), Unité de recherche Plantes et Systèmes de Culture Horticoles ( PSH ), Institut National de la Recherche Agronomique ( INRA ), University of Northern British Columbia ( UNBC ), Biogéosciences [Dijon] ( BGS ), Université de Bourgogne ( UB ) -AgroSup Dijon - Institut National Supérieur des Sciences Agronomiques, de l'Alimentation et de l'Environnement-Centre National de la Recherche Scientifique ( CNRS ), Polska Akademia Nauk ( PAN ) -Museum and Institute of Zoology, University of Latvia ( LU ), Consejo Nacional de Investigaciones Científicas y Técnicas ( CONICET ), Polska Akademia Nauk ( PAN ), Ecologie Systématique et Evolution ( ESE ), Université Paris-Sud - Paris 11 ( UP11 ) -AgroParisTech-Centre National de la Recherche Scientifique ( CNRS ), Consejo Superior de Investigaciones Científicas [Spain] ( CSIC ) -Museo Nacional de Ciencias Naturales, University of Coimbra [Portugal] ( UC ), Institute of Ecology & Evolution ( IEE ), National Taiwan University [Taiwan] ( NTU ), University of Gothenburg ( GU ), Department of Biosciences, University of Oslo ( UiO ), Eötvös Loránd University ( ELTE ), and Cornell University Museum of Vertebrates
Subjects: PASSERINES, 0106 biological sciences, Nest-box, design, measures, PARUS, SECONDARY CAVITY-NESTING BIRDS, Otras Ciencias Biológicas, NEST SITES, FLYCATCHER, Ficedula, 010603 evolutionary biology, 01 natural sciences, [ SDV.EE ] Life Sciences [q-bio]/Ecology, environment, 010605 ornithology, methods, field experiments, Ciencias Biológicas, nestboxes, tit, Cyanistes, Research based, Statistics, NESTBOXES, FIELD EXPERIMENTS, Nest box, Biological sciences, Biology, secondary cavity-nesting birds, FICEDULA, Parus, [SDV.EE]Life Sciences [q-bio]/Ecology, environment, [ SDE.BE ] Environmental Sciences/Biodiversity and Ecology, biology, Ecology, nest sites, passerines, biology.organism_classification, 3. Good health, TIT, Settore AGR/11 - Entomologia Generale E Applicata, CYANISTES, flycatcher, METHODS, Nesting (computing), Animal Science and Zoology, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, CIENCIAS NATURALES Y EXACTAS
Abstract: The widespread use of artificial nestboxes has led to significant advances in our knowledge of the ecology, behaviour and physiology of cavity nesting birds, especially small passerines. Nestboxes have made it easier to perform routine monitoring and experimental manipulation of eggs or nestlings, and also repeatedly to capture, identify and manipulate the parents. However, when comparing results across study sites the use of nestboxes may also introduce a potentially significant confounding variable in the form of differences in nestbox design amongst studies, such as their physical dimensions, placement height, and the way in which they are constructed and maintained. However, the use of nestboxes may also introduce an unconsidered and potentially significant confounding variable due to differences in nestbox design amongst studies, such as their physical dimensions, placement height, and the way in which they are constructed and maintained. Here we review to what extent the characteristics of artificial nestboxes (e.g. size, shape, construction material, colour) are documented in the 'methods' sections of publications involving hole-nesting passerine birds using natural or excavated cavities or artificial nestboxes for reproduction and roosting. Despite explicit previous recommendations that authors describe in detail the characteristics of the nestboxes used, we found that the description of nestbox characteristics in most recent publications remains poor and insufficient. We therefore list the types of descriptive data that should be included in the methods sections of relevant manuscripts and justify this by discussing how variation in nestbox characteristics can affect or confound conclusions from nestbox studies. We also propose several recommendations to improve the reliability and usefulness of research based on long-term studies of any secondary hole-nesting species using artificial nestboxes for breeding or roosting.
Published: 2010

36. Catalytic and photoresponsive BiZ/CuxS heterojunctions with surface vacancies for the treatment of multidrug-resistant clinical biofilm-associated infections

Author: Chih-Ching Huang, Daniel M Chevrier, Yu-Feng Lin, Fu-Chieh Chang, Fan-Gang Tseng, Yu-Fen Huang, Huan-Tsung Chang, Lung Chang, Hao-Hsin Huang, Yu-Ting Tseng, Arumugam Sangili, Amit Nain, Institute of Physics, Academia Sinica, National Tsing Hua University [Hsinchu] (NTHU), National Taiwan Ocean University (NTOU), Institut de Biosciences et Biotechnologies d'Aix-Marseille (ex-IBEB) (BIAM), Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS)-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA), and National Taiwan University [Taiwan] (NTU)
Subjects: chemistry.chemical_classification, Nanocomposite, biology, Biocompatibility, Sulfide, Chemistry, Biofilm, Photothermal therapy, Multiple drug resistance, [SPI]Engineering Sciences [physics], mental disorders, biology.protein, General Materials Science, Bovine serum albumin, Antibacterial activity, Nuclear chemistry
Abstract: International audience; Copper/bismuth sulfide heterojunctions boost the catalytic and photoresponsive properties engendered antibacterial activity against clinically isolated multidrug-resistant bacteria and their associated biofilms.We report a one-pot facile synthesis of highly photoresponsive bovine serum albumin (BSA) templated bismuth-copper sulfide nanocomposites (BSA-BiZ/CuxS NCs, where BiZ represents in situ formed Bi2S3 and bismuth oxysulfides (BOS)). As-formed surface vacancies and BiZ/CuxS heterojunctions impart superior catalytic, photodynamic and photothermal properties. Upon near-infrared (NIR) irradiation, the BSA-BiZ/CuxS NCs exhibit broad-spectrum antibacterial activity, not only against standard multidrug-resistant (MDR) bacterial strains but also against clinically isolated MDR bacteria and their associated biofilms. The minimum inhibitory concentration of BSA-BiZ/CuxS NCs is 14-fold lower than that of BSA-CuxS NCs because their multiple heterojunctions and vacancies facilitated an amplified phototherapeutic response. As-prepared BSA-BiZ/CuxS NCs exhibited substantial biofilm inhibition (90%) and eradication (>75%) efficiency under NIR irradiation. Furthermore, MRSA-infected diabetic mice were immensely treated with BSA-BiZ/CuxS NCs coupled with NIR irradiation by destroying the mature biofilm on the wound site, which accelerated the wound healing process via collagen synthesis and epithelialization. We demonstrate that BSA-BiZ/CuxS NCs with superior antimicrobial activity and high biocompatibility hold great potential as an effective photosensitive agent for the treatment of biofilm-associated infections.
Published: 2021

37. OR and analytics for digital, resilient, and sustainable manufacturing 4.0

Author: Tsan-Ming Choi, Alexandre Dolgui, Dmitry Ivanov, Erwin Pesch, National Taiwan University [Taiwan] (NTU), Département Automatique, Productique et Informatique (IMT Atlantique - DAPI), IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Modélisation, Optimisation et DEcision pour la Logistique, l'Industrie et les Services (LS2N - équipe MODELIS), Laboratoire des Sciences du Numérique de Nantes (LS2N), Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-École Centrale de Nantes (Nantes Univ - ECN), Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes université - UFR des Sciences et des Techniques (Nantes univ - UFR ST), Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Sciences et technologie, Nantes Université (Nantes Univ)-Institut National de Recherche en Informatique et en Automatique (Inria)-Centre National de la Recherche Scientifique (CNRS)-IMT Atlantique (IMT Atlantique), Nantes Université (Nantes Univ), Berlin School of Economics and Law, Universität Siegen [Siegen], and Handelshochschule Leipzig - Graduate School of Management (HHL)
Subjects: [INFO.INFO-AU]Computer Science [cs]/Automatic Control Engineering, General Decision Sciences, [INFO]Computer Science [cs], [INFO.INFO-RO]Computer Science [cs]/Operations Research [cs.RO], Management Science and Operations Research
Abstract: préface; International audience; This special issue publishes contributions from the operations research (OR) communityin the following areas and at the intersections of those areas, namely manufacturing andsupply chain digitalization, resilience, and sustainability. The application areas of OR andanalytics to digital, resilient, and sustainable manufacturing systems may contain descriptiveand diagnostic analyses, predictive simulation and prescriptive optimization, real time con-trol, and adaptive learning. Examples of OR and analytics applications include logistics andsupply chain control with real-time data, inventory control and management using sensingdata, dynamic resource allocation in Industry 4.0 customized assembly systems, improvingforecasting models using big data, machine learning techniques for process control, networkvisibility and risk control, optimizing systems based on predictive information (e.g., pre-dictive maintenance), combining optimization and machine learning algorithms, and supplychain risk analytics.
Published: 2022

38. A deep learning approach for the dynamic dispatching of unreliable machines in re-entrant production systems

Author: Chi-Kang Tsai, Cheng-Hung Wu, Fang-Yi Zhou, Stéphane Dauzère-Pérès, Cheng-Juei Yu, National Taiwan University [Taiwan] (NTU), Département Sciences de la Fabrication et Logistique (SFL-ENSMSE), École des Mines de Saint-Étienne (Mines Saint-Étienne MSE), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-CMP-GC, Laboratoire d'Informatique, de Modélisation et d'Optimisation des Systèmes (LIMOS), Ecole Nationale Supérieure des Mines de St Etienne-Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS), Institute for Information Industry (III), Institut Mines-Télécom [Paris] (IMT), Ecole Nationale Supérieure des Mines de St Etienne (ENSM ST-ETIENNE)-Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA)-Institut national polytechnique Clermont Auvergne (INP Clermont Auvergne), and Université Clermont Auvergne (UCA)-Université Clermont Auvergne (UCA)
Subjects: 0209 industrial biotechnology, 021103 operations research, ComputingMilieux_THECOMPUTINGPROFESSION, Artificial neural network, Computer science, business.industry, Strategy and Management, Deep learning, 0211 other engineering and technologies, [INFO.INFO-RO]Computer Science [cs]/Operations Research [cs.RO], 02 engineering and technology, Deep neural network, Management Science and Operations Research, Industrial and Manufacturing Engineering, Markov decision processes, 020901 industrial engineering & automation, Production (economics), Re entrant, Markov decision process, Artificial intelligence, Dynamic dispatching, business, ComputingMilieux_MISCELLANEOUS
Abstract: This research combines deep neural network (DNN) and Markov decision processes (MDP) for the dynamic dispatching of re-entrant production systems. In re-entrant production systems, jobs enter the same workstation multiple times and dynamic dispatching oftentimes aims to dynamically assign different priorities to various job groups to minimise weighted cycle time or maximise throughput. MDP is an effective tool for dynamic production control, but it suffers from two major challenges in dynamic control problems. First, the curse of dimensionality limits the computational performance of solving large MDP problems. Second, a different model should be built and solved after system configuration is changed. DNN is used to overcome both challenges by learning directly from optimal dispatching policies generated by MDP. Results suggest that a properly trained DNN model can instantly generate near-optimal dynamic control policies for large problems. The quality of the DNN solution is compared with the optimal dynamic control policies through the standard K-fold cross-validation test and discrete event simulation. On average, the performance of the DNN policy is within 2% of optimal in both tests. The proposed artificial intelligence algorithm illustrates the potential of machine learning methods in manufacturing applications.
Published: 2020

39. Datations radiométriques (U-Th, U-Pb) et paléodosimétrique (ESR) des plus anciens sites préhistoriques des Alpes-Maritimes : la grotte du Vallonnet, le site de plein air de Terra Amata et la grotte du Lazaret

Author: Michel, Véronique, Shen, Guanjun, Shen, Chuan-Chou, Duval, Mathieu, Woodhead, Jon, Chou, Yu- Min, Hu, Hsun-Ming, Wu, Chung-Che, Kan, Yu-Chun, Yang, Huihui, Yu, Tsai-Luen, Gallet, Sylvain, Valensi, Patricia, Moullé, Pierre-Elie, Cauche, Dominique, Moncel, Marie- Hélène, Echassoux, Anna, De Lumley, Henry, Culture et Environnements, Préhistoire, Antiquité, Moyen-Age (CEPAM), Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA), Géoazur (GEOAZUR 7329), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), College of Geographical Sciences, Nanjing Normal University (NNU), High-Precision Mass Spectrometry and Environment Change Laboratory (HISPEC), National Taiwan University [Taiwan] (NTU), Centro Nacional de Investigación sobre la Evolución Humana (CENIEH), School of Earth Sciences, University of Melbourne, Center of Marine Magnetism, Department of Ocean Science and Engineering, Department of Chemistry and Applied Biosciences [ETH Zürich] (D-CHAB), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Marine Industry and Engineering Research Center, National Academy of Marine Research, Histoire naturelle de l'Homme préhistorique (HNHP), Muséum national d'Histoire naturelle (MNHN)-Université de Perpignan Via Domitia (UPVD)-Centre National de la Recherche Scientifique (CNRS), Musée de Préhistoire de Tourrette-Levens, Musée de Préhistoire Régionale de Menton, Centre National de la Recherche Scientifique (CNRS), Institut de Paléontologie Humaine (IPH), Fondation I.P.H-Centre National de la Recherche Scientifique (CNRS), and Henry de Lumley, Elena Rossoni-Notter
Subjects: [SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, [SHS]Humanities and Social Sciences
Abstract: International audience; Les premières migrations « Out of Africa » des homininés vers l’Europe sont enregistrées en Géorgie, à Dmanisi, un site préhistorique daté à 1,8 Ma (Garcia et al., 2010 ; Ferring et al., 2011). Les homininés découverts à Dmanisi, occupaient le site au cours d’un climat chaud et sec, similaire au climat méditerranéen actuel (Blain et al., 2014). Ils se sont dispersés alors vers l’Europe de l’Ouest, où des sites ont été bien datés à Orce par exemple, témoignant de leur présence en Espagne, avec Barranco Leon daté à 1,4 Ma (Toro-Moyano et al., 2013) et Fuente Nueva-3 daté à 1,19-1,5 Ma (Duval et aL, 2012 ; Alvarez et al., 2015). La présence de Homo antecessor a été aussi datée à la Sima del Elefante, à 1,2-1,1 Ma (Carbonell et al., 2008). On retrouve alors les traces de ces anciens homininés dans les Alpes-Maritimes, à la grotte du Vallonnet, où ils y ont laissé des outils archaïques et des restes de faune épivillafranchienne portant des marques évidentes de découpe. Nous présenterons les dernières datations à 1,19-1,2 Ma obtenues par la méthode U-Pb de ce site le plus ancien des Alpes-Maritimes. L’occupation humaine du site se situe au cours du stade isotopique MIS 36-35, avec un climat frais et sec à la base de la séquence archéologique suivie d’un climat tempéré et humide d’après la paléontologie. Une évolution humaine et culturelle qui perdure par la suite dans cette région, avec la présence des Homo erectus sur le site de plein air de Terra Amata, dont nous rappellerons l’ancienne datation par ESR à environ 380 ka (Yokoyama et al., 1985) et les résultats de la biochronologie qui situent les occupations au cours d’une période tempérée au stade isotopique MIS 11. Les Homo erectus ont occupé le site à plusieurs reprises, à la belle saison, et y ont laissé une industrie du Paléolithique inférieur. Plus tard, ils sont présents à la grotte du Lazaret, avec une industrie de l’Acheuléen final, associée à des restes fauniques portant de nombreuses marques anthropiques. La faune indique un climat frais et humide, au cours du stade isotopique MIS 6. Les dernières datations, présentées ici et obtenues par les méthodes ESR, U-Th et le paléomagnétisme sur les niveaux pléistocènes du site, permettent de situer les niveaux archéologiques entre 190 ka et 120 ka.
Published: 2022

40. Influence of early identification and therapy on long-term outcomes in early-onset MTHFR deficiency

Author: Yverneau, Mathilde, Leroux, Stéphanie, Imbard, Apolline, Gleich, Florian, Arion, Alina, Moreau, Caroline, Nassogne, Marie-Cécile, Szymanowski, Marie, Tardieu, Marine, Touati, Guy, Bueno, María, Chapman, Kimberly A, Chien, Yin-Hsiu, Huemer, Martina, Ješina, Pavel, Janssen, Mirian C H, Kölker, Stefan, Kožich, Viktor, Lavigne, Christian, Lund, Allan Meldgaard, Mochel, Fanny, Morris, Andrew, Pons, Mónica Ruiz, Porras-Hurtado, Gloria Liliana, Benoist, Jean-François, Damaj, Léna, Schiff, Manuel, E-HOD Consortium, CHU Pontchaillou [Rennes], AP-HP Hôpital universitaire Robert-Debré [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Heidelberg University Hospital [Heidelberg], Service de Pédiatrie Médicale [Caen], Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Université Catholique de Louvain = Catholic University of Louvain (UCL), CHU Estaing [Clermont-Ferrand], CHU Clermont-Ferrand, CHU Trousseau [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Hospital Universitario Virgen del Rocío [Sevilla], Children’s National Health System [Washington, DC, USA], National Taiwan University [Taiwan] (NTU), University Children’s Hospital Zurich, Charles University [Prague] (CU), Radboud University Medical Center [Nijmegen], Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Copenhagen University Hospital, CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Manchester University NHS Foundation Trust (MFT), Hospital Universitario N.S. de Candelaria [Santa Cruz de Tenerife, Spain], Hôpital Robert Debré Paris, Hôpital Robert Debré, Imagine - Institut des maladies génétiques (IHU) (Imagine - U1163), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), European Union [739543], EU-project phase [2012 12 02], SOBI, Recordati Rare Disease Foundation, Aeglea, and Jonchère, Laurent
Subjects: newborn screening, [SDV]Life Sciences [q-bio], MTHFR deficiency, Infant, Newborn, neurodevelopmental outcome, Metabolic Disorders Radboud Institute for Molecular Life Sciences [Radboudumc 6], digestive system diseases, [SDV] Life Sciences [q-bio], Cohort Studies, homocystinuria, Psychotic Disorders, EHOD, Muscle Spasticity, Genetics, Humans, remethylation defects, Homocystinuria, Homocysteine, Genetics (clinical), Methylenetetrahydrofolate Reductase (NADPH2), Retrospective Studies
Abstract: Contains fulltext : 286882.pdf (Publisher’s version ) (Closed access) MTHFR deficiency is a severe inborn error of metabolism leading to impairment of the remethylation of homocysteine to methionine. Neonatal and early-onset patients mostly exhibit a life-threatening acute neurologic deterioration. Furthermore, data on early-onset patients' long-term outcomes are scarce. The aims of this study were (1) to study and describe the clinical and laboratory parameters of early-onset MTHFR-deficient patients (i.e., ≤3 months of age) and (2) to identify predictive factors for severe neurodevelopmental outcomes in a cohort with early and late onset MTHFR-deficient patients. To this end, we conducted a retrospective, multicentric, international cohort study on 72 patients with MTHFR deficiency from 32 international metabolic centres. Characteristics of the 32 patients with early-onset MTHFR deficiency were described at time of diagnosis and at the last follow-up visit. Logistic regression analysis was used to identify predictive factors of severe neurodevelopmental outcome in a broader set of patients with early and non-early-onset MTHFR deficiency. The majority of early-onset MTHFR-deficient patients (n = 32) exhibited neurologic symptoms (76%) and feeding difficulties (70%) at time of diagnosis. At the last follow-up visit (median follow-up time of 8.1 years), 76% of treated early-onset patients (n = 29) exhibited a severe neurodevelopmental outcome. Among the whole study population of 64 patients, pre-symptomatic diagnosis was independently associated with a significantly better neurodevelopmental outcome (adjusted OR 0.004, [0.002-0.232]; p = 0.003). This study provides evidence for benefits of pre-symptomatic diagnosis and appropriate therapeutic management, highlighting the need for systematic newborn screening for MTHFR deficiency and pre-symptomatic treatment that may improve outcome.
Published: 2022

41. National identity predicts public health support during a global pandemic

Author: Van Bavel, Jay J., Cichocka, Aleksandra, Capraro, Valerio, Sjåstad, Hallgeir, Nezlek, John B., Pavlović, Tomislav, Alfano, Mark, Gelfand, Michele J., Azevedo, Flavio, Birtel, Michèle D., Cislak, Aleksandra, Lockwood, Patricia L., Ross, Robert Malcolm, Abts, Koen, Agadullina, Elena, Aruta, John Jamir Benzon, Besharati, Sahba Nomvula, Bor, Alexander, Choma, Becky L., Crabtree, Charles David, Cunningham, William A., De, Koustav, Ejaz, Waqas, Elbaek, Christian T., Findor, Andrej, Flichtentrei, Daniel, Franc, Renata, Gjoneska, Biljana, Gruber, June, Gualda, Estrella, Horiuchi, Yusaku, Huynh, Toan Luu Duc, Ibanez, Agustin, Imran, Mostak Ahamed, Israelashvili, Jacob, Jasko, Katarzyna, Kantorowicz, Jaroslaw, Kantorowicz-Reznichenko, Elena, Krouwel, André, Laakasuo, Michael, Lamm, Claus, Leygue, Caroline, Lin, Ming-Jen, Mansoor, Mohammad Sabbir, Marie, Antoine, Mayiwar, Lewend, Mazepus, Honorata, McHugh, Cillian, Minda, John Paul, Mitkidis, Panagiotis, Olsson, Andreas, Otterbring, Tobias, Packer, Dominic J., Perry, Anat, Petersen, Michael Bang, Puthillam, Arathy, Riaño-Moreno, Julián C., Rothmund, Tobias, Santamaría-García, Hernando, Schmid, Petra C., Stoyanov, Drozdstoy, Tewari, Shruti, Todosijević, Bojan, Tsakiris, Manos, Tung, Hans H., Umbreș, Radu G., Vanags, Edmunds, Vlasceanu, Madalina, Vonasch, Andrew, Yucel, Meltem, Zhang, Yucheng, Abad, Mohcine, Adler, Eli, Akrawi, Narin, Mdarhri, Hamza Alaoui, Amara, Hanane, Amodio, David M., Antazo, Benedict G., Apps, Matthew, Ay, F. Ceren, Ba, Mouhamadou Hady, Barbosa, Sergio, Bastian, Brock, Berg, Anton, Bernal-Zárate, Maria P., Bernstein, Michael, Białek, Michał, Bilancini, Ennio, Bogatyreva, Natalia, Boncinelli, Leonardo, Booth, Jonathan E., Borau, Sylvie, Buchel, Ondrej, Cameron, C. Daryl, Carvalho, Chrissie F., Celadin, Tatiana, Cerami, Chiara, Chalise, Hom Nath, Cheng, Xiaojun, Cian, Luca, Cockcroft, Kate, Conway, Jane, Córdoba-Delgado, Mateo Andres, Crespi, Chiara, Crouzevialle, Marie, Cutler, Jo, Cypryańska, Marzena, Dabrowska, Justyna, Daniels, Michael A., Davis, Victoria H., Dayley, Pamala N., Delouvee, Sylvain, Denkovski, Ognjan, Dezecache, Guillaume, Dhaliwal, Nathan A., Diato, Alelie B., Di Paolo, Roberto, Drosinou, Marianna, Dulleck, Uwe, Ekmanis, Jānis, Ertan, Arhan S., Etienne, Tom W., Farhana, Hapsa Hossain, Farkhari, Fahima, Farmer, Harry, Fenwick, Ali, Fidanovski, Kristijan, Flew, Terry, Fraser, Shona, Frempong, Raymond Boadi, Fugelsang, Jonathan A., Gale, Jessica, Garcia-Navarro, E. Begoña, Garladinne, Prasad, Ghajjou, Oussama, Gkinopoulos, Theofilos, Gray, Kurt, Griffin, Siobhán M., Gronfeldt, Bjarki, Gümren, Mert, Gurung, Ranju Lama, Halperin, Eran, Harris, Elizabeth, Herzon, Volo, Hruška, Matej, Huang, Guanxiong, Hudecek, Matthias F. C., Isler, Ozan, Jangard, Simon, Jørgensen, Frederik J., Kachanoff, Frank, Kahn, John, Dangol, Apsara Katuwal, Keudel, Oleksandra, Koppel, Lina, Koverola, Mika, Kubin, Emily, Kunnari, Anton, Kutiyski, Yordan, Laguna, Oscar, Leota, Josh, Lermer, Eva, Levy, Jonathan, Levy, Neil, Li, Chunyun, Long, Elizabeth U., Longoni, Chiara, Maglić, Marina, McCashin, Darragh, Metcalf, Alexander L., Mikloušić, Igor, El Mimouni, Soulaimane, Miura, Asako, Molina-Paredes, Juliana, Monroy-Fonseca, César, Morales-Marente, Elena, Moreau, David, Muda, Rafał, Myer, Annalisa, Nash, Kyle, Nesh-Nash, Tarik, Nitschke, Jonas P., Nurse, Matthew S., Ohtsubo, Yohsuke, Oldemburgo De Mello, Victoria, O’Madagain, Cathal, Onderco, Michal, Palacios-Galvez, M. Soledad, Palomäki, Jussi, Pan, Yafeng, Papp, Zsófia, Pärnamets, Philip, Paruzel-Czachura, Mariola, Pavlović, Zoran, Payán-Gómez, César, Perander, Silva, Pitman, Michael Mark, Prasad, Rajib, Pyrkosz-Pacyna, Joanna, Rathje, Steve, Raza, Ali, Rêgo, Gabriel G., Rhee, Kasey, Robertson, Claire E., Rodríguez-Pascual, Iván, Saikkonen, Teemu, Salvador-Ginez, Octavio, Sampaio, Waldir M., Santi, Gaia C., Santiago-Tovar, Natalia, Savage, David, Scheffer, Julian A., Schönegger, Philipp, Schultner, David T., Schutte, Enid M., Scott, Andy, Sharma, Madhavi, Sharma, Pujan, Skali, Ahmed, Stadelmann, David, Stafford, Clara Alexandra, Stanojević, Dragan, Stefaniak, Anna, Sternisko, Anni, Stoica, Agustin, Stoyanova, Kristina K., Strickland, Brent, Sundvall, Jukka, Thomas, Jeffrey P., Tinghög, Gustav, Torgler, Benno, Traast, Iris J., Tucciarelli, Raffaele, Tyrala, Michael, Ungson, Nick D., Uysal, Mete S., Van Lange, Paul A. M., Van Prooijen, Jan-Willem, Van Rooy, Dirk, Västfjäll, Daniel, Verkoeijen, Peter, Vieira, Joana B., Von Sikorski, Christian, Walker, Alexander Cameron, Watermeyer, Jennifer, Wetter, Erik, Whillans, Ashley, Willardt, Robin, Wohl, Michael J. A., Wójcik, Adrian Dominik, Wu, Kaidi, Yamada, Yuki, Yilmaz, Onurcan, Yogeeswaran, Kumar, Ziemer, Carolin-Theresa, Zwaan, Rolf A., Boggio, Paulo S., Van Bavel, Jay J., Cichocka, Aleksandra, Capraro, Valerio, Sjåstad, Hallgeir, Nezlek, John B., Pavlović, Tomislav, Alfano, Mark, Gelfand, Michele J., Azevedo, Flavio, Birtel, Michèle D., Cislak, Aleksandra, Lockwood, Patricia L., Ross, Robert Malcolm, Abts, Koen, Agadullina, Elena, Aruta, John Jamir Benzon, Besharati, Sahba Nomvula, Bor, Alexander, Choma, Becky L., Crabtree, Charles David, Cunningham, William A., De, Koustav, Ejaz, Waqa, Elbaek, Christian T., Findor, Andrej, Flichtentrei, Daniel, Franc, Renata, Gjoneska, Biljana, Gruber, June, Gualda, Estrella, Horiuchi, Yusaku, Huynh, Toan Luu Duc, Ibanez, Augustin, Imran, Mostak Ahamed, Israelashvili, Jacob, Jasko, Katarzyna, Kantorowicz, Jaroslaw, Kantorowicz-Reznichenko, Elena, Krouwel, André, Laakasuo, Michael, Lamm, Clau, Leygue, Caroline, Lin, Ming-Jen, Mansoor, Mohammad Sabbir, Marie, Antoine, Mayiwar, Lewend, Mazepus, Honorata, McHugh, Cillian, Minda, John Paul, Mitkidis, Panagioti, Olsson, Andrea, Otterbring, Tobia, Packer, Dominic J., Perry, Anat, Petersen, Michael Bang, Puthillam, Arathy, Riaño-Moreno, Julián C., Rothmund, Tobia, Santamaría-García, Hernando, Schmid, Petra C., Stoyanov, Drozdstoy, Tewari, Shruti, Todosijević, Bojan, Tsakiris, Mano, Tung, Hans H., Umbreș, Radu G., Vanags, Edmund, Vlasceanu, Madalina, Vonasch, Andrew, Yucel, Meltem, Zhang, Yucheng, Abad, Mohcine, Adler, Eli, Akrawi, Narin, Mdarhri, Hamza Alaoui, Amara, Hanane, Amodio, David M., Antazo, Benedict G., Apps, Matthew, Ay, F. Ceren, Ba, Mouhamadou Hady, Barbosa, Sergio, Bastian, Brock, Berg, Anton, Bernal-Zárate, Maria P., Bernstein, Michael, Białek, Michał, Bilancini, Ennio, Bogatyreva, Natalia, Boncinelli, Leonardo, Booth, Jonathan E., Borau, Sylvie, Buchel, Ondrej, Cameron, C. Daryl, Carvalho, Chrissie F., Celadin, Tatiana, Cerami, Chiara, Chalise, Hom Nath, Cheng, Xiaojun, Cian, Luca, Cockcroft, Kate, Conway, Jane, Córdoba-Delgado, Mateo Andre, Crespi, Chiara, Crouzevialle, Marie, Cutler, Jo, Cypryańska, Marzena, Dabrowska, Justyna, Daniels, Michael A., Davis, Victoria H., Dayley, Pamala N., Delouvee, Sylvain, Denkovski, Ognjan, Dezecache, Guillaume, Dhaliwal, Nathan A., Diato, Alelie B., Di Paolo, Roberto, Drosinou, Marianna, Dulleck, Uwe, Ekmanis, Jāni, Ertan, Arhan S., Etienne, Tom W., Farhana, Hapsa Hossain, Farkhari, Fahima, Farmer, Harry, Fenwick, Ali, Fidanovski, Kristijan, Flew, Terry, Fraser, Shona, Frempong, Raymond Boadi, Fugelsang, Jonathan A., Gale, Jessica, Garcia-Navarro, E. Begoña, Garladinne, Prasad, Ghajjou, Oussama, Gkinopoulos, Theofilo, Gray, Kurt, Griffin, Siobhán M., Gronfeldt, Bjarki, Gümren, Mert, Gurung, Ranju Lama, Halperin, Eran, Harris, Elizabeth, Herzon, Volo, Hruška, Matej, Huang, Guanxiong, Hudecek, Matthias F. C., Isler, Ozan, Jangard, Simon, Jørgensen, Frederik J., Kachanoff, Frank, Kahn, John, Dangol, Apsara Katuwal, Keudel, Oleksandra, Koppel, Lina, Koverola, Mika, Kubin, Emily, Kunnari, Anton, Kutiyski, Yordan, Laguna, Oscar, Leota, Josh, Lermer, Eva, Levy, Jonathan, Levy, Neil, Li, Chunyun, Long, Elizabeth U., Longoni, Chiara, Maglić, Marina, McCashin, Darragh, Metcalf, Alexander L., Mikloušić, Igor, El Mimouni, Soulaimane, Miura, Asako, Molina-Paredes, Juliana, Monroy-Fonseca, César, Morales-Marente, Elena, Moreau, David, Muda, Rafał, Myer, Annalisa, Nash, Kyle, Nesh-Nash, Tarik, Nitschke, Jonas P., Nurse, Matthew S., Ohtsubo, Yohsuke, Oldemburgo de Mello, Victoria, O’Madagain, Cathal, Onderco, Michal, Palacios-Galvez, M. Soledad, Palomäki, Jussi, Pan, Yafeng, Papp, Zsófia, Pärnamets, Philip, Paruzel-Czachura, Mariola, Pavlović, Zoran, Payán-Gómez, César, Perander, Silva, Pitman, Michael Mark, Prasad, Rajib, Pyrkosz-Pacyna, Joanna, Rathje, Steve, Raza, Ali, Rêgo, Gabriel G., Rhee, Kasey, Robertson, Claire E., Rodríguez-Pascual, Iván, Saikkonen, Teemu, Salvador-Ginez, Octavio, Sampaio, Waldir M., Santi, Gaia C., Santiago-Tovar, Natalia, Savage, David, Scheffer, Julian A., Schönegger, Philipp, Schultner, David T., Schutte, Enid M., Scott, Andy, Sharma, Madhavi, Sharma, Pujan, Skali, Ahmed, Stadelmann, David, Stafford, Clara Alexandra, Stanojević, Dragan, Stefaniak, Anna, Sternisko, Anni, Stoica, Augustin, Stoyanova, Kristina K., Strickland, Brent, Sundvall, Jukka, Thomas, Jeffrey P., Tinghög, Gustav, Torgler, Benno, Traast, Iris J., Tucciarelli, Raffaele, Tyrala, Michael, Ungson, Nick D., Uysal, Mete S., Van Lange, Paul A. M., van Prooijen, Jan-Willem, van Rooy, Dirk, Västfjäll, Daniel, Verkoeijen, Peter, Vieira, Joana B., von Sikorski, Christian, Walker, Alexander Cameron, Watermeyer, Jennifer, Wetter, Erik, Whillans, Ashley, Willardt, Robin, Wohl, Michael J. A., Wójcik, Adrian Dominik, Wu, Kaidi, Yamada, Yuki, Yilmaz, Onurcan, Yogeeswaran, Kumar, Ziemer, Carolin-Theresa, Zwaan, Rolf A., Boggio, Paulo S., Department of Digital Humanities, Faculty Common Matters (Faculty of Arts), Cognitive Science, Helsinki Research Hub on Religion, Media and Social Change, Helsinki Social Computing Group, Doctoral Programme in Cognition, Learning, Instruction and Communication, Mind and Matter, High Performance Cognition group, Medicum, Digital Humanities, Law and Economics, Pharmacy, Public Administration, Molecular Genetics, Research Methods and Techniques, Brain and Cognition, Van Bavel, Jay J [0000-0002-2520-0442], Cichocka, Aleksandra [0000-0003-1703-1586], Sjåstad, Hallgeir [0000-0002-8730-1038], Nezlek, John B [0000-0003-4963-3637], Pavlović, Tomislav [0000-0002-4470-3715], Alfano, Mark [0000-0001-5879-8033], Azevedo, Flavio [0000-0001-9000-8513], Cislak, Aleksandra [0000-0002-9880-6947], Lockwood, Patricia L [0000-0001-7195-9559], Ross, Robert Malcolm [0000-0001-8711-1675], Abts, Koen [0000-0001-8546-8347], Agadullina, Elena [0000-0002-1505-1412], Aruta, John Jamir Benzon [0000-0003-4155-1063], Besharati, Sahba Nomvula [0000-0003-2836-7982], Bor, Alexander [0000-0002-2624-9221], Crabtree, Charles David [0000-0001-5144-8671], De, Koustav [0000-0001-9562-0672], Ejaz, Waqas [0000-0002-2492-4115], Elbaek, Christian T [0000-0002-7039-4565], Findor, Andrej [0000-0002-5896-6989], Franc, Renata [0000-0002-1909-2393], Gjoneska, Biljana [0000-0003-1200-6672], Huynh, Toan Luu Duc [0000-0002-1486-127X], Ibanez, Augustin [0000-0001-6758-5101], Imran, Mostak Ahamed [0000-0002-5101-3149], Kantorowicz, Jaroslaw [0000-0002-1186-5427], Krouwel, André [0000-0003-0952-6028], Laakasuo, Michael [0000-0003-2826-6073], Lamm, Claus [0000-0002-5422-0653], Leygue, Caroline [0000-0002-0355-1030], Lin, Ming-Jen [0000-0002-7174-2226], Mansoor, Mohammad Sabbir [0000-0002-6541-3506], Marie, Antoine [0000-0002-7958-0153], McHugh, Cillian [0000-0002-9701-3232], Minda, John Paul [0000-0002-4081-010X], Mitkidis, Panagiotis [0000-0002-9495-7369], Olsson, Andreas [0000-0001-5272-7744], Otterbring, Tobias [0000-0002-0283-8777], Perry, Anat [0000-0003-2329-856X], Petersen, Michael Bang [0000-0002-6782-5635], Riaño-Moreno, Julián C [0000-0003-4182-0550], Rothmund, Tobias [0000-0003-2979-5129], Schmid, Petra C [0000-0002-9990-5445], Stoyanov, Drozdstoy [0000-0002-9975-3680], Todosijević, Bojan [0000-0002-6116-993X], Tsakiris, Manos [0000-0001-7753-7576], Tung, Hans H [0000-0001-5332-7582], Vanags, Edmunds [0000-0003-1932-936X], Vlasceanu, Madalina [0000-0003-2138-1968], Yucel, Meltem [0000-0002-7274-5971], Zhang, Yucheng [0000-0001-9435-6734], Abad, Mohcine [0000-0002-4964-5411], Mdarhri, Hamza Alaoui [0000-0001-9831-6561], Amara, Hanane [0000-0003-0732-2320], Antazo, Benedict G [0000-0001-9993-8960], Apps, Matthew [0000-0001-5793-2202], Barbosa, Sergio [0000-0003-1989-158X], Bastian, Brock [0000-0003-4619-3322], Bernal-Zárate, Maria P [0000-0001-8232-6220], Białek, Michał [0000-0002-5062-5733], Boncinelli, Leonardo [0000-0003-0626-5133], Booth, Jonathan E [0000-0002-8563-4613], Borau, Sylvie [0000-0003-1564-0695], Buchel, Ondrej [0000-0002-0139-5513], Chalise, Hom Nath [0000-0002-9301-6890], Cian, Luca [0000-0002-8051-1366], Cockcroft, Kate [0000-0002-6166-8050], Conway, Jane [0000-0003-3883-349X], Córdoba-Delgado, Mateo Andres [0000-0002-2264-7388], Crouzevialle, Marie [0000-0002-5538-6030], Cutler, Jo [0000-0003-1073-764X], Dabrowska, Justyna [0000-0002-8821-7161], Davis, Victoria H [0000-0002-7207-4629], Dayley, Pamala N [0000-0001-8955-9502], Delouvee, Sylvain [0000-0002-4029-597X], Di Paolo, Roberto [0000-0002-6081-6656], Dulleck, Uwe [0000-0002-0953-5963], Ekmanis, Jānis [0000-0003-1781-1785], Etienne, Tom W [0000-0002-4299-6593], Farkhari, Fahima [0000-0002-8484-5128], Farmer, Harry [0000-0002-3684-0605], Fenwick, Ali [0000-0002-5412-9745], Flew, Terry [0000-0003-4485-9338], Frempong, Raymond Boadi [0000-0002-4603-5570], Gale, Jessica [0000-0001-5677-8629], Garcia-Navarro, E Begoña [0000-0001-6913-8882], Ghajjou, Oussama [0000-0002-2975-0265], Griffin, Siobhán M [0000-0002-3613-2844], Halperin, Eran [0000-0002-3379-2935], Herzon, Volo [0000-0001-7781-1651], Huang, Guanxiong [0000-0002-8588-1454], Hudecek, Matthias FC [0000-0002-7696-766X], Isler, Ozan [0000-0002-4638-2230], Jangard, Simon [0000-0002-7876-4161], Jørgensen, Frederik J [0000-0002-5461-912X], Kahn, John [0000-0002-0548-3123], Koppel, Lina [0000-0002-6302-0047], Koverola, Mika [0000-0001-8227-6120], Leota, Josh [0000-0002-7714-4630], Lermer, Eva [0000-0002-6600-9580], Maglić, Marina [0000-0002-6851-4601], Metcalf, Alexander L [0000-0001-9532-585X], Miura, Asako [0000-0002-7563-7503], Monroy-Fonseca, César [0000-0003-4696-8159], Morales-Marente, Elena [0000-0002-1227-9606], Moreau, David [0000-0002-1957-1941], Nesh-Nash, Tarik [0000-0002-5532-9095], Nitschke, Jonas P [0000-0002-3244-8585], Nurse, Matthew S [0000-0003-1787-5914], Palomäki, Jussi [0000-0001-6063-0926], Pan, Yafeng [0000-0002-5633-8313], Pavlović, Zoran [0000-0002-9231-5100], Payán-Gómez, César [0000-0002-0633-1332], Perander, Silva [0000-0001-6711-8079], Pitman, Michael Mark [0000-0001-5532-5388], Pyrkosz-Pacyna, Joanna [0000-0002-9112-8629], Raza, Ali [0000-0002-2438-6054], Rhee, Kasey [0000-0002-8562-0801], Rodríguez-Pascual, Iván [0000-0002-5385-3643], Saikkonen, Teemu [0000-0001-9619-3270], Sampaio, Waldir M [0000-0002-6066-4314], Schönegger, Philipp [0000-0001-9930-487X], Schultner, David T [0000-0003-2253-4065], Scott, Andy [0000-0002-3294-0078], Skali, Ahmed [0000-0002-4753-3280], Stadelmann, David [0000-0002-1211-9936], Stafford, Clara Alexandra [0000-0003-1716-7870], Stanojević, Dragan [0000-0002-3667-2461], Stefaniak, Anna [0000-0002-1706-7784], Sternisko, Anni [0000-0002-2507-3076], Stoica, Augustin [0000-0003-0585-1114], Sundvall, Jukka [0000-0003-4310-1162], Tinghög, Gustav [0000-0002-8159-1249], Torgler, Benno [0000-0002-9809-963X], Tucciarelli, Raffaele [0000-0002-0342-308X], Tyrala, Michael [0000-0001-5268-8319], Van Lange, Paul AM [0000-0001-7774-6984], van Prooijen, Jan-Willem [0000-0001-6236-0819], Västfjäll, Daniel [0000-0003-2873-4500], von Sikorski, Christian [0000-0002-3787-8277], Walker, Alexander Cameron [0000-0003-1431-6770], Watermeyer, Jennifer [0000-0001-7918-8832], Whillans, Ashley [0000-0002-1726-6978], Willardt, Robin [0000-0002-2495-3450], Wohl, Michael JA [0000-0001-6945-5562], Wójcik, Adrian Dominik [0000-0002-7073-6019], Wu, Kaidi [0000-0001-6881-7437], Yamada, Yuki [0000-0003-1431-568X], Yilmaz, Onurcan [0000-0002-6094-7162], Ziemer, Carolin-Theresa [0000-0002-0794-7702], Apollo - University of Cambridge Repository, Communication Science, Network Institute, Communication Choices, Content and Consequences (CCCC), Social Psychology, IBBA, A-LAB, New York University [New York] (NYU), NYU System (NYU), University of Kent [Canterbury], Middlesex University [London], Norwegian School of Economics and Business Administration, SWPS University of Social Sciences and Humanities (SWPS), College of William and Mary [Williamsburg] (WM), Ivo Pilar Institute of Social Sciences, Macquarie University, Stanford University, Friedrich-Schiller-Universität = Friedrich Schiller University Jena [Jena, Germany], University of Greenwich, University of Oxford, University of Birmingham [Birmingham], Catholic University of Leuven - Katholieke Universiteit Leuven (KU Leuven), Vysšaja škola èkonomiki = National Research University Higher School of Economics [Moscow] (HSE), De La Salle University [Manila] (DLSU), University of the Witwatersrand [Johannesburg] (WITS), Aarhus University [Aarhus], University of Toronto, Dartmouth College [Hanover], University of Kentucky (UK), National University of Sciences and Technology [Islamabad] (NUST), Comenius University in Bratislava, IntraMed, Buenos Aires, DF, Argentina, Macedonian Academy of Sciences and Arts [Skopje, North Macedonia] (MASA), University of Colorado [Boulder], Universidad de Huelva, WHU-Otto Beisheim School of Management, University Adolfo Ibanez (Santiago), University of Dhaka, The Hebrew University of Jerusalem (HUJ), Uniwersytet Jagielloński w Krakowie = Jagiellonian University (UJ), Universiteit Leiden, Erasmus University Rotterdam, Vrije Universiteit Amsterdam [Amsterdam] (VU), Helsingin yliopisto = Helsingfors universitet = University of Helsinki, University of Vienna [Vienna], Universidad Nacional Autónoma de México = National Autonomous University of Mexico (UNAM), National Taiwan University [Taiwan] (NTU), Tribhuvan University, BI Norwegian Business School [Oslo], University of Limerick (UL), University of Western Ontario (UWO), Duke University [Durham], Karolinska Institute, University of Agder (UIA), Lehigh University [Bethlehem], Monk Prayogshala, Cooperative University of Colombia, Pontificia Universidad Javeriana (PUJ), Department of Management, Technology, and Economics [ETH Zürich] (D-MTEC), Eidgenössische Technische Hochschule - Swiss Federal Institute of Technology [Zürich] (ETH Zürich), Medical University of Plovdiv, Indian Institute of Management Indore (IMM Indore), Institute of Social Sciences Belgrade, University of London [London], University of Luxembourg [Luxembourg], National School of Political and Administrative Studies (SNSPA), University of Latvia (LU), Princeton University, University of Canterbury [Christchurch], University of Virginia, Hebei University of Technology [Tianjin], Université Mohammed VI Polytechnique [Ben Guerir] (UM6P), Institute for Research and Development-Kurdistan, University of Amsterdam [Amsterdam] (UvA), Jose Rizal Memorial State University, Université Cheikh Anta Diop [Dakar, Sénégal] (UCAD), Universidad del Rosario [Bogota], University of Melbourne, Penn State Abington, Pennsylvania Commonwealth System of Higher Education (PCSHE)-Penn State System, University of Wrocław [Poland] (UWr), IMT Alti Studi Lucca, Università degli Studi di Firenze = University of Florence (UniFI), London School of Economics and Political Science (LSE), Toulouse School of Economics (TSE-R), Université Toulouse Capitole (UT Capitole), Université de Toulouse (UT)-Université de Toulouse (UT)-École des hautes études en sciences sociales (EHESS)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), Tilburg University [Tilburg], Netspar, Pennsylvania State University (Penn State), Penn State System, Universidade Federal de Santa Catarina = Federal University of Santa Catarina [Florianópolis] (UFSC), University of Bologna/Università di Bologna, Istituto Universitario di Studi Superiori (IUSS), Shenzhen University [Shenzhen], Institute for Advanced Study in Toulouse (IAST), Università degli Studi di Pavia = University of Pavia (UNIPV), Cracow University of Economics, University of British Columbia (UBC), University of California [Los Angeles] (UCLA), University of California (UC), Laboratoire de Psychologie : Cognition, Comportement, Communication (LP3C - EA1285), Université de Bretagne Sud (UBS)-Université de Brest (UBO)-Université de Rennes 2 (UR2)-Institut Brestois des Sciences de l'Homme et de la Société (IBSHS), Université de Brest (UBO), Laboratoire de Psychologie Sociale et Cognitive (LAPSCO), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne (UCA), University of British Columbia [Vancouver], Cavite State University-General Trias City Campus, School for Advanced Studies Lucca (IMT), Queensland University of Technology [Brisbane] (QUT), Australian National University (ANU), Boǧaziçi üniversitesi = Boğaziçi University [Istanbul], Kieskompas, Hult International Business School Dubai, The University of Sydney, University of Bayreuth, University of Waterloo [Waterloo], University of Bradford, University of Crete [Heraklion] (UOC), University of North Carolina [Chapel Hill] (UNC), University of North Carolina System (UNC), Koç University, City University of Hong Kong [Hong Kong] (CUHK), University of Regensburg, Universität Duisburg-Essen = University of Duisburg-Essen [Essen], Free University of Berlin (FU), Linköping University (LIU), University of Koblenz-Landau, University of Alberta, Ludwig Maximilian University [Munich] (LMU), Interdisciplinary Center Herzliya (IDC), Aalto University, Macquarie University [Sydney], Boston University [Boston] (BU), Dublin City University [Dublin] (DCU), University of Montana, Osaka University [Osaka], SEELE Neuroscience, University of Auckland [Auckland], Maria Curie-Sklodowska University (UMCS), CUNY Graduate Center (The Graduate Center), City University of New York [New York] (CUNY), The University of Tokyo (UTokyo), Mohammed VI Polytechnic University, Hungarian Academy of Sciences (MTA), Medical University of Silesia (SUM), University of Belgrade [Belgrade], Vidyasagar College For Women, AGH University of Science and Technology [Krakow, PL] (AGH UST), University of Cambridge [UK] (CAM), Mackenzie Presbyterian University [São Paulo] (UPM), University of Turku, University of Newcastle [Callaghan, Australia] (UoN), University of St Andrews [Scotland], University of Groningen [Groningen], Carleton University, National University of Political Studies and Public Administration Bucharest, Romania (SNSPA), University of Plovdiv, Institut Jean-Nicod (IJN), Département d'Etudes Cognitives - ENS Paris (DEC), École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-École des hautes études en sciences sociales (EHESS)-Collège de France (CdF (institution))-Centre National de la Recherche Scientifique (CNRS)-Département de Philosophie - ENS Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), Center for Research in Economics, Management and the Arts (CREMA), Partenaires INRAE, University College of London [London] (UCL), The Hong Kong University of Science and Technology, Susquehanna University, Dokuz Eylül Üniversitesi = Dokuz Eylül University [Izmir] (DEÜ), Stockholm School of Economics (SSE), Harvard Business School, Harvard University, Nicolaus Copernicus University [Toruń], University of California [San Diego] (UC San Diego), Kyushu University, Kadir Has University (KHAS), Van Bavel, Jay J. [0000-0002-2520-0442], Nezlek, John B. [0000-0003-4963-3637], Lockwood, Patricia L. [0000-0001-7195-9559], Elbaek, Christian T. [0000-0002-7039-4565], Ibanez, Agustin [0000-0001-6758-5101], Riaño-Moreno, Julián C. [0000-0003-4182-0550], Schmid, Petra C. [0000-0002-9990-5445], Tung, Hans H. [0000-0001-5332-7582], Antazo, Benedict G. [0000-0001-9993-8960], Bernal-Zárate, Maria P. [0000-0001-8232-6220], Booth, Jonathan E. [0000-0002-8563-4613], Davis, Victoria H. [0000-0002-7207-4629], Dayley, Pamala N. [0000-0001-8955-9502], Etienne, Tom W. [0000-0002-4299-6593], Garcia-Navarro, E. Begoña [0000-0001-6913-8882], Griffin, Siobhán M. [0000-0002-3613-2844], Hudecek, Matthias F. C. [0000-0002-7696-766X], Jørgensen, Frederik J. [0000-0002-5461-912X], Metcalf, Alexander L. [0000-0001-9532-585X], Nitschke, Jonas P. [0000-0002-3244-8585], Nurse, Matthew S. [0000-0003-1787-5914], Sampaio, Waldir M. [0000-0002-6066-4314], Schultner, David T. [0000-0003-2253-4065], Stoica, Agustin [0000-0003-0585-1114], Van Lange, Paul A. M. [0000-0001-7774-6984], Wohl, Michael J. A. [0000-0001-6945-5562], New York University, University of Kent, Middlesex University, Norwegian School of Economics, College of William and Mary, Institute of Social Sciences Ivo Pilar, Friedrich Schiller University Jena, SWPS University of Social Sciences and Humanities, KU Leuven, Higher School of Economics, De La Salle University Manila, University of the Witwatersrand, Aarhus University, X University, Dartmouth College, University of Kentucky, National University of Sciences and Technology Pakistan, IntraMed, Macedonian Academy of Sciences and Arts, University of Colorado Boulder, University of Huelva, Otto Beisheim School of Management, Universidad Adolfo Ibáñez, Hebrew University of Jerusalem, Jagiellonian University in Kraków, Leiden University, Vrije Universiteit Amsterdam, University of Helsinki, University of Vienna, Universidad Nacional Autónoma de México, National Taiwan University, BI Norwegian Business School, University of Limerick, Western University, Karolinska Institutet, University of Agder, Lehigh University, Universidad Cooperativa de Colombia, Universidad Javeriana, Swiss Federal Institute of Technology Zurich, Indian Institute of Management Indore, Institute of Social Sciences, Royal Holloway University of London, University of Latvia, University of Canterbury, Duke University, Hebei University of Technology, University of Kurdistan, Impact For Development, Jose Rizal University, University of Birmingham, Université Cheikh Anta Diop de Dakar, Universidad del Rosario, Pennsylvania State University, University of Wrocław, IMT Institute for Advanced Studies Lucca, University of Florence, Birkbeck University of London, Toulouse Business School, Tilburg University, Universidade Federal de Santa Catarina, Universita di Bologna, University of Pavia, Shenzhen University, Université Toulouse 1 Capitole, IRCCS Fondazione Istituto Neurologico Casimiro Mondino - Pavia, University of British Columbia, University of California Los Angeles, University of Rennes 2, University of Amsterdam, Université Clermont Auvergne, Cavite State University, Queensland University of Technology, Bogazici University, University of Sydney, University of Waterloo, University of North Carolina at Chapel Hill, Koc University, City University of Hong Kong, Free University of Berlin, Linköping University, Ludwig Maximilian University of Munich, Department of Neuroscience and Biomedical Engineering, Boston University, Dublin City University, Osaka University, University of Auckland, Maria Curie-Sklodowska University, Australian National University, The University of Tokyo, Hungarian Academy of Sciences, University of Silesia in Katowice, University of Belgrade, University of Calcutta, AGH University of Science and Technology, University of Cambridge, Universidade Presbiteriana Mackenzie, University of Newcastle, University of St Andrews, University of Groningen, National School of Political and Administrative Studies, University College London, Hong Kong University of Science and Technology, Dokuz Eylul University, Stockholm School of Economics, Nicolaus Copernicus University in Toruń, University of California San Diego, Kadir Has University, Aalto-yliopisto, University of St Andrews. School of International Relations, University of St Andrews. School of Psychology and Neuroscience, Van Bavel, J, Cichocka, A, Capraro, V, Sjastad, H, Nezlek, J, Pavlovic, T, Alfano, M, Gelfand, M, Azevedo, F, Birtel, M, Cislak, A, Lockwood, P, Ross, R, Abts, K, Agadullina, E, Aruta, J, Besharati, S, Bor, A, Choma, B, Crabtree, C, Cunningham, W, De, K, Ejaz, W, Elbaek, C, Findor, A, Flichtentrei, D, Franc, R, Gjoneska, B, Gruber, J, Gualda, E, Horiuchi, Y, Huynh, T, Ibanez, A, Imran, M, Israelashvili, J, Jasko, K, Kantorowicz, J, Kantorowicz-Reznichenko, E, Krouwel, A, Laakasuo, M, Lamm, C, Leygue, C, Lin, M, Mansoor, M, Marie, A, Mayiwar, L, Mazepus, H, Mchugh, C, Minda, J, Mitkidis, P, Olsson, A, Otterbring, T, Packer, D, Perry, A, Petersen, M, Puthillam, A, Riano-Moreno, J, Rothmund, T, Santamaria-Garcia, H, Schmid, P, Stoyanov, D, Tewari, S, Todosijevic, B, Tsakiris, M, Tung, H, Umbres, R, Vanags, E, Vlasceanu, M, Vonasch, A, Yucel, M, Zhang, Y, Abad, M, Adler, E, Akrawi, N, Mdarhri, H, Amara, H, Amodio, D, Antazo, B, Apps, M, Ay, F, Ba, M, Barbosa, S, Bastian, B, Berg, A, Bernal-Zarate, M, Bernstein, M, Bialek, M, Bilancini, E, Bogatyreva, N, Boncinelli, L, Booth, J, Borau, S, Buchel, O, Cameron, C, Carvalho, C, Celadin, T, Cerami, C, Chalise, H, Cheng, X, Cian, L, Cockcroft, K, Conway, J, Cordoba-Delgado, M, Crespi, C, Crouzevialle, M, Cutler, J, Cypryanska, M, Dabrowska, J, Daniels, M, Davis, V, Dayley, P, Delouvee, S, Denkovski, O, Dezecache, G, Dhaliwal, N, Diato, A, Di Paolo, R, Drosinou, M, Dulleck, U, Ekmanis, J, Ertan, A, Etienne, T, Farhana, H, Farkhari, F, Farmer, H, Fenwick, A, Fidanovski, K, Flew, T, Fraser, S, Frempong, R, Fugelsang, J, Gale, J, Garcia-Navarro, E, Garladinne, P, Ghajjou, O, Gkinopoulos, T, Gray, K, Griffin, S, Gronfeldt, B, Gumren, M, Gurung, R, Halperin, E, Harris, E, Herzon, V, Hruska, M, Huang, G, Hudecek, M, Isler, O, Jangard, S, Jorgensen, F, Kachanoff, F, Kahn, J, Dangol, A, Keudel, O, Koppel, L, Koverola, M, Kubin, E, Kunnari, A, Kutiyski, Y, Laguna, O, Leota, J, Lermer, E, Levy, J, Levy, N, Li, C, Long, E, Longoni, C, Maglic, M, Mccashin, D, Metcalf, A, Miklousic, I, El Mimouni, S, Miura, A, Molina-Paredes, J, Monroy-Fonseca, C, Morales-Marente, E, Moreau, D, Muda, R, Myer, A, Nash, K, Nesh-Nash, T, Nitschke, J, Nurse, M, Ohtsubo, Y, Oldemburgo de Mello, V, O'Madagain, C, Onderco, M, Palacios-Galvez, M, Palomaki, J, Pan, Y, Papp, Z, Parnamets, P, Paruzel-Czachura, M, Pavlovic, Z, Payan-Gomez, C, Perander, S, Pitman, M, Prasad, R, Pyrkosz-Pacyna, J, Rathje, S, Raza, A, Rego, G, Rhee, K, Robertson, C, Rodriguez-Pascual, I, Saikkonen, T, Salvador-Ginez, O, Sampaio, W, Santi, G, Santiago-Tovar, N, Savage, D, Scheffer, J, Schonegger, P, Schultner, D, Schutte, E, Scott, A, Sharma, M, Sharma, P, Skali, A, Stadelmann, D, Stafford, C, Stanojevic, D, Stefaniak, A, Sternisko, A, Stoica, A, Stoyanova, K, Strickland, B, Sundvall, J, Thomas, J, Tinghog, G, Torgler, B, Traast, I, Tucciarelli, R, Tyrala, M, Ungson, N, Uysal, M, Van Lange, P, van Prooijen, J, van Rooy, D, Vastfjall, D, Verkoeijen, P, Vieira, J, von Sikorski, C, Walker, A, Watermeyer, J, Wetter, E, Whillans, A, Willardt, R, Wohl, M, Wojcik, A, Wu, K, Yamada, Y, Yilmaz, O, Yogeeswaran, K, Ziemer, C, Zwaan, R, and Boggio, P
Subjects: IMAGE, Health Behavior, COVID-19, national identity, public health, pandemic, cross-cultural, Collective narcissism, Settore SECS-P/02 - Politica Economica, health behavior, Sociology, RA0421 Public health. Hygiene. Preventive Medicine, Settore SECS-P/01 - Economia Politica, public health behaviours, COVID-19, collective behaviour, Public health, [SHS.SOCIO]Humanities and Social Sciences/Sociology, Social Identification, 706/689/477/2811, article, Social identity, Public Health, Global Health, Social Medicine and Epidemiology, [SHS.ECO]Humanities and Social Sciences/Economics and Finance, 3142 Public health care science, environmental and occupational health, VDP::Medisinske Fag: 700::Helsefag: 800, 5141 Sociology, Settore SECS-P/03 - Scienza delle Finanze, National identity, Human, Cross-Cultural Comparison, BF Psychology, Science, COVID-19 pandemic, BF, national narcissism, HV Social pathology. Social and public welfare. Criminology, Humans, Leadership, Pandemics, Public Health, SARS-CoV-2, Self Report, Social Conformity, Human development, 692/699/255/2514, SDG 3 - Good Health and Well-being, Human behaviour, political ideology, COLLECTIVE NARCISSISM, SOCIAL IDENTITY, MCC, Pandemic, IDENTIFICATION, DAS, [SHS.SCIPO]Humanities and Social Sciences/Political science, Coronavirus, MODEL, Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi, Viral infection, Idenfication, Image, RA Public aspects of medicine, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, Human medicine, RA, Model
Abstract: Funder: Research Council of Norway through its Centres of Excellence Scheme, FAIR project No 262675, Funder: J. William Fulbright Program, Funder: Institute for Lifecourse Development, University of Greenwich, Funder: Economic Social Research Council Impact Acceleration Award, University of Oxford, Funder: Institute of Social Sciences Ivo Pilar, Funder: Academy of Finland (Suomen Akatemia); doi: https://doi.org/10.13039/501100002341, Funder: Universität Wien (University of Vienna); doi: https://doi.org/10.13039/501100003065, Funder: Ministry of Science and Technology, Taiwan (Ministry of Science and Technology of Taiwan); doi: https://doi.org/10.13039/501100004663, Funder: NOMIS Stiftung (NOMIS Foundation); doi: https://doi.org/10.13039/501100008483, Funder: Princeton Graduate Student Research Funding (Program in Cognitive Science), Funder: Corruption Laboratory on Ethics, Accountability, and the Rule of Law (CLEAR), University of Virginia, Funder: Project Pro.Co.P.E., IMT School (PAI2019), Funder: Italian Ministry of University and Research - PRIN 2017 (20178293XT), Funder: Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada (Conseil de Recherches en Sciences Naturelles et en Génie du Canada); doi: https://doi.org/10.13039/501100000038, Funder: Australian Research Council (DP180102384), Funder: Ernst and Young (EY); doi: https://doi.org/10.13039/501100003064, Changing collective behaviour and supporting non-pharmaceutical interventions is an important component in mitigating virus transmission during a pandemic. In a large international collaboration (Study 1, N = 49,968 across 67 countries), we investigated self-reported factors associated with public health behaviours (e.g., spatial distancing and stricter hygiene) and endorsed public policy interventions (e.g., closing bars and restaurants) during the early stage of the COVID-19 pandemic (April-May 2020). Respondents who reported identifying more strongly with their nation consistently reported greater engagement in public health behaviours and support for public health policies. Results were similar for representative and non-representative national samples. Study 2 (N = 42 countries) conceptually replicated the central finding using aggregate indices of national identity (obtained using the World Values Survey) and a measure of actual behaviour change during the pandemic (obtained from Google mobility reports). Higher levels of national identification prior to the pandemic predicted lower mobility during the early stage of the pandemic (r = −0.40). We discuss the potential implications of links between national identity, leadership, and public health for managing COVID-19 and future pandemics.
Published: 2022

42. Using polygenic scores and clinical data for bipolar disorder patient stratification and lithium response prediction: Machine learning approach

Author: Cearns, Micah, Amare, Azmeraw, Schubert, Klaus Oliver, Thalamuthu, Anbupalam, Frank, Joseph, Streit, Fabian, Adli, Mazda, Akula, Nirmala, Akiyama, Kazufumi, Ardau, Raffaella, Arias, Bárbara, Aubry, Jean-Michel, Backlund, Lena, Bhattacharjee, Abesh Kumar, Bellivier, Frank, Benabarre, Antonio, Bengesser, Susanne, Biernacka, Joanna, Birner, Armin, Brichant-Petitjean, Clara, Cervantes, Pablo, Chen, Hsi-Chung, Chillotti, Caterina, Cichon, Sven, Cruceanu, Cristiana, Czerski, Piotr, Dalkner, Nina, Dayer, Alexandre, Degenhardt, Franziska, Zompo, Maria Del, Depaulo, J Raymond, Étain, Bruno, Falkai, Peter, Forstner, Andreas, Frisen, Louise, Frye, Mark, Fullerton, Janice, Gard, Sébastien, Garnham, Julie, Goes, Fernando, Grigoroiu-Serbanescu, Maria, Grof, Paul, Hashimoto, Ryota, Hauser, Joanna, Heilbronner, Urs, Herms, Stefan, Hoffmann, Per, Hofmann, Andrea, Hou, Liping, Hsu, Yi-Hsiang, Jamain, Stephane, Jiménez, Esther, Kahn, Jean-Pierre, Kassem, Layla, Kuo, Po-Hsiu, Kato, Tadafumi, Kelsoe, John, Kittel-Schneider, Sarah, Kliwicki, Sebastian, König, Barbara, Kusumi, Ichiro, Laje, Gonzalo, Landén, Mikael, Lavebratt, Catharina, Leboyer, Marion, Leckband, Susan, Maj, Mario, Manchia, Mirko, Martinsson, Lina, Mccarthy, Michael, Mcelroy, Susan, Colom, Francesc, Mitjans, Marina, Mondimore, Francis, Monteleone, Palmiero, Nievergelt, Caroline, Nöthen, Markus, Novák, Tomas, O'Donovan, Claire, Ozaki, Norio, Millischer, Vincent, Papiol, Sergi, Pfennig, Andrea, Pisanu, Claudia, Potash, James, Reif, Andreas, Reininghaus, Eva, Rouleau, Guy, Rybakowski, Janusz, Schalling, Martin, Schofield, Peter, Schweizer, Barbara, Severino, Giovanni, Shekhtman, Tatyana, Shilling, Paul, Shimoda, Katzutaka, Simhandl, Christian, Slaney, Claire, Squassina, Alessio, Stamm, Thomas, Stopkova, Pavla, Tekola-Ayele, Fasil, Tortorella, Alfonso, Turecki, Gustavo, Veeh, Julia, Vieta, Eduard, Witt, Stephanie, Roberts, Gloria, Zandi, Peter, Alda, Martin, Bauer, Michael, Mcmahon, Francis, Mitchell, Philip, Schulze, Thomas, Rietschel, Marcella, Clark, Scott, Baune, Bernhard, Cearns, Micah, Amare, Azmeraw T, Schubert, Klaus Oliver, Thalamuthu, Anbupalam, Frank, Joseph, Streit, Fabian, Adli, Mazda, Akula, Nirmala, Akiyama, Kazufumi, Ardau, Raffaella, Arias, Bárbara, Aubry, Jean-Michel, Backlund, Lena, Bhattacharjee, Abesh Kumar, Bellivier, Frank, Benabarre, Antonio, Bengesser, Susanne, Biernacka, Joanna M, Birner, Armin, Brichant-Petitjean, Clara, Cervantes, Pablo, Chen, Hsi-Chung, Chillotti, Caterina, Cichon, Sven, Cruceanu, Cristiana, Czerski, Piotr M, Dalkner, Nina, Dayer, Alexandre, Degenhardt, Franziska, Zompo, Maria Del, Depaulo, J Raymond, Étain, Bruno, Falkai, Peter, Forstner, Andreas J, Frisen, Louise, Frye, Mark A, Fullerton, Janice M, Gard, Sébastien, Garnham, Julie S, Goes, Fernando S, Grigoroiu-Serbanescu, Maria, Grof, Paul, Hashimoto, Ryota, Hauser, Joanna, Heilbronner, Ur, Herms, Stefan, Hoffmann, Per, Hofmann, Andrea, Hou, Liping, Hsu, Yi-Hsiang, Jamain, Stephane, Jiménez, Esther, Kahn, Jean-Pierre, Kassem, Layla, Kuo, Po-Hsiu, Kato, Tadafumi, Kelsoe, John, Kittel-Schneider, Sarah, Kliwicki, Sebastian, König, Barbara, Kusumi, Ichiro, Laje, Gonzalo, Landén, Mikael, Lavebratt, Catharina, Leboyer, Marion, Leckband, Susan G, Maj, Mario, Manchia, Mirko, Martinsson, Lina, Mccarthy, Michael J, Mcelroy, Susan, Colom, Francesc, Mitjans, Marina, Mondimore, Francis M, Monteleone, Palmiero, Nievergelt, Caroline M, Nöthen, Markus M, Novák, Toma, O'Donovan, Claire, Ozaki, Norio, Millischer, Vincent, Papiol, Sergi, Pfennig, Andrea, Pisanu, Claudia, Potash, James B, Reif, Andrea, Reininghaus, Eva, Rouleau, Guy A, Rybakowski, Janusz K, Schalling, Martin, Schofield, Peter R, Schweizer, Barbara W, Severino, Giovanni, Shekhtman, Tatyana, Shilling, Paul D, Shimoda, Katzutaka, Simhandl, Christian, Slaney, Claire M, Squassina, Alessio, Stamm, Thoma, Stopkova, Pavla, Tekola-Ayele, Fasil, Tortorella, Alfonso, Turecki, Gustavo, Veeh, Julia, Vieta, Eduard, Witt, Stephanie H, Roberts, Gloria, Zandi, Peter P, Alda, Martin, Bauer, Michael, Mcmahon, Francis J, Mitchell, Philip B, Schulze, Thomas G, Rietschel, Marcella, Clark, Scott R, Baune, Bernhard T, Etain, Bruno, University of South Australia [Adelaide], South Australian Health and Medical Research Institute [ Adelaide] (SAHMRI), Centre for Healthy Brain Ageing (CHeBA), School of Psychiatry, UNSW Medicine, University of New South Wales, Sydney, University Medical Center Heidelberg, Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], National Institute of Mental Health (NIMH), National Institutes of Health [Bethesda] (NIH), Dokkyo Medical University, Università degli Studi di Cagliari = University of Cagliari (UniCa), University of Barcelona, Centro de Investigación Biomédica en Red Salud Mental [Madrid] (CIBER-SAM), Hôpital Universitaire de Genève = University Hospitals of Geneva (HUG), Karolinska Institute, Karolinska University Hospital [Stockholm], University of California [San Diego] (UC San Diego), University of California (UC), Optimisation thérapeutique en Neuropsychopharmacologie (OPTeN (UMR_S_1144 / U1144)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Institut d'Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Universitat de Barcelona (UB), Medical University of Graz, Department of Health Sciences Research [Mayo Clinic] (HSR), Mayo Clinic, McGill University Health Center [Montreal] (MUHC), National Taiwan University [Taiwan] (NTU), University of Bonn, University Hospital Basel [Basel], Douglas Mental Health University Institute [Montréal], McGill University = Université McGill [Montréal, Canada], Poznan University of Medical Sciences [Poland] (PUMS), Johns Hopkins University (JHU), Ludwig Maximilian University [Munich] (LMU), University of Basel (Unibas), Karolinska Institutet [Stockholm], University of New South Wales [Sydney] (UNSW), Centre hospitalier Charles Perrens [Bordeaux], Dalhousie University [Halifax], 'Prof. Dr. Alexandru Obregia' Clinical Hospital of Psychiatry [Bucharest, Romania], Mood Disorders Center of Ottawa (MDCO), University of Ottawa [Ottawa], Osaka University [Osaka], Georg-August-University = Georg-August-Universität Göttingen, University Medical Center Göttingen (UMG), Institute of Psychiatric Phenomics and Genomics (IPPG), Ludwig-Maximilians-Universität München (LMU), Harvard School of Public Health, Harvard Medical School [Boston] (HMS), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Centre Psychothérapique de Nancy [Laxou] (CPN), Juntendo University, Frankfurt University Hospital, Landesklinikum Neunkirchen (LK Neunkirchen), Hokkaido University [Sapporo, Japan], Sahlgrenska Academy at University of Gothenburg [Göteborg], VA San Diego Healthcare System [San Diego, CA, USA] (VASDHS), Università degli studi della Campania 'Luigi Vanvitelli' = University of the Study of Campania Luigi Vanvitelli, University of Cincinnati (UC), IMIM-Hospital del Mar, Generalitat de Catalunya, Instituto de Salud Carlos III [Madrid] (ISC), Università degli Studi di Salerno = University of Salerno (UNISA), National Institute of Mental Health [Klecany, Czech Republic] (NIMH), Nagoya University, Medizinische Universität Wien = Medical University of Vienna, University Hospital Carl Gustav Carus [Dresden, Germany], Technische Universität Dresden = Dresden University of Technology (TU Dresden), Montreal Neurological Institute and Hospital, Neuroscience Research Australia (NeuRA), Sigmund Freud University (SFU), Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD), Università degli Studi di Perugia = University of Perugia (UNIPG), Medical Faculty [Mannheim], Universität Heidelberg [Heidelberg], Johns Hopkins Bloomberg School of Public Health [Baltimore], University Medical Center, University of Adelaide, Westfälische Wilhelms-Universität Münster = University of Münster (WWU), Melbourne Medical School [Melbourne], Faculty of Medicine, Dentistry and Health Sciences [Melbourne], University of Melbourne-University of Melbourne, University of Melbourne, and The Florey Institute of Neuroscience and Mental Health
Subjects: Psychiatry and Mental health, depressive disorder, bipolar affective disorder, outcome studies, [SDV.MHEP.PSM]Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, Mood stabiliser, Mood stabilisers, [SDV.MHEP.PSM] Life Sciences [q-bio]/Human health and pathology/Psychiatrics and mental health, genetics, genetic, depressive disorders, bipolar affective disorders
Abstract: BackgroundResponse to lithium in patients with bipolar disorder is associated with clinical and transdiagnostic genetic factors. The predictive combination of these variables might help clinicians better predict which patients will respond to lithium treatment.AimsTo use a combination of transdiagnostic genetic and clinical factors to predict lithium response in patients with bipolar disorder.MethodThis study utilised genetic and clinical data (n = 1034) collected as part of the International Consortium on Lithium Genetics (ConLi+Gen) project. Polygenic risk scores (PRS) were computed for schizophrenia and major depressive disorder, and then combined with clinical variables using a cross-validated machine-learning regression approach. Unimodal, multimodal and genetically stratified models were trained and validated using ridge, elastic net and random forest regression on 692 patients with bipolar disorder from ten study sites using leave-site-out cross-validation. All models were then tested on an independent test set of 342 patients. The best performing models were then tested in a classification framework.ResultsThe best performing linear model explained 5.1% (P = 0.0001) of variance in lithium response and was composed of clinical variables, PRS variables and interaction terms between them. The best performing non-linear model used only clinical variables and explained 8.1% (P = 0.0001) of variance in lithium response. A priori genomic stratification improved non-linear model performance to 13.7% (P = 0.0001) and improved the binary classification of lithium response. This model stratified patients based on their meta-polygenic loadings for major depressive disorder and schizophrenia and was then trained using clinical data.ConclusionsUsing PRS to first stratify patients genetically and then train machine-learning models with clinical predictors led to large improvements in lithium response prediction. When used with other PRS and biological markers in the future this approach may help inform which patients are most likely to respond to lithium treatment.
Published: 2022

43. Les scientifiques mettent en garde contre les menaces qui pèsent sur les montagnes

Author: Dirk S. Schmeller, Davnah Urbach, Kieran Bates, Jordi Catalan, Dan Cogălniceanu, Matthew C. Fisher, Jan Friesen, Leopold Füreder, Veronika Gaube, Marilen Haver, Dean Jacobsen, Gael Le Roux, Yu-Pin Lin, Adeline Loyau, Oliver Machate, Andreas Mayer, Ignacio Palomo, Christoph Plutzar, Hugo Sentenac, Ruben Sommaruga, Rocco Tiberti, William J. Ripple, Institut National Polytechnique (Toulouse) (Toulouse INP), Université de Toulouse (UT), Laboratoire Ecologie Fonctionnelle et Environnement (LEFE), Institut Ecologie et Environnement (INEE), Centre National de la Recherche Scientifique (CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS)-Institut National Polytechnique (Toulouse) (Toulouse INP), University of Bern, Imperial College London, CSIC-UAB, CREAF, Universitat Autònoma de Barcelona (UAB), Ovidius University of Constanta, Helmholtz Zentrum für Umweltforschung = Helmholtz Centre for Environmental Research (UFZ), Ecology, University of Innsbruck, Leopold Franzens Universität Innsbruck - University of Innsbruck, University of Natural Resources and Life Sciences Vienna, Partenaires IRSTEA, Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA)-Institut national de recherche en sciences et technologies pour l'environnement et l'agriculture (IRSTEA), Department of Biology [Copenhagen], Faculty of Science [Copenhagen], University of Copenhagen = Københavns Universitet (UCPH)-University of Copenhagen = Københavns Universitet (UCPH), Centre National de la Recherche Scientifique (CNRS), National Taiwan University [Taiwan] (NTU), Leibniz Institute of Freshwater Ecology and Inland Fisheries (IGB), Institut des Géosciences de l’Environnement (IGE), Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), Universität für Bodenkultur Wien = University of Natural Resources and Life [Vienne, Autriche] (BOKU), Università degli Studi di Pavia = University of Pavia (UNIPV), Oregon State University (OSU), and ANR-19-MPGA-0009,PORTAL,Pathways for Transformation in the Alps(2019)
Subjects: Conservation of Natural Resources, Environmental Engineering, Water, environmental health, Biodiversity, 580 Plants (Botany), sustainable development goals, Pollution, Carbon, climate change, Animals, Humans, Environmental Chemistry, [SDE.BE]Environmental Sciences/Biodiversity and Ecology, Waste Management and Disposal, Ecosystem, policy
Abstract: International audience; Mountains are an essential component of the global life-support system. They are characterized by a rugged, heterogenous landscape with rapidly changing environmental conditions providing myriad ecological niches over relatively small spatial scales. Although montane species are well adapted to life at extremes, they are highly vulnerable to human derived ecosystem threats. Here we build on the manifesto 'World Scientists' Warning to Humanity', issued by the Alliance of World Scientists, to outline the major threats to mountain ecosystems. We highlight climate change as the greatest threat to mountain ecosystems, which are more impacted than their lowland counterparts. We further discuss the cascade of "knock-on" effects of climate change such as increased UV radiation, altered hydrological cycles, and altered pollution profiles; highlighting the biological and socioeconomic consequences. Finally, we present how intensified use of mountains leads to overexploitation and abstraction of water, driving changes in carbon stock, reducing biodiversity, and impacting ecosystem functioning. These perturbations can provide opportunities for invasive species, parasites and pathogens to colonize these fragile habitats, driving further changes and losses of micro-and macrobiodiversity, as well further impacting ecosystem services. Ultimately, imbalances in the normal functioning of mountain ecosystems will lead to changes in vital biological, biochemical, and chemical processes, critically reducing ecosystem health with widespread repercussions for animal and human wellbeing. Developing tools in species/habitat conservation and future restoration is therefore essential if we are to effectively mitigate against the declining health of mountains.
Published: 2022
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44. Desorption timescales on epitaxial graphene via Fermi level shifting and Reststrahlen monitoring

Author: Ngoc Thanh Mai Tran, Swapnil M. Mhatre, Cristiane N. Santos, Adam J. Biacchi, Mathew L. Kelley, Heather M. Hill, Dipanjan Saha, Chi-Te Liang, Randolph E. Elmquist, David B. Newell, Benoit Hackens, Christina A. Hacker, Albert F. Rigosi, UCL - SST/IMCN/NAPS - Nanoscopic Physics, National Institute of Standards and Technology [Gaithersburg] (NIST), National Taiwan University [Taiwan] (NTU), Institut d’Électronique, de Microélectronique et de Nanotechnologie - UMR 8520 (IEMN), Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), Photonique THz - IEMN (PHOTONIQUE THZ - IEMN), Université catholique de Lille (UCL)-Université catholique de Lille (UCL)-Centrale Lille-Université de Lille-Centre National de la Recherche Scientifique (CNRS)-Université Polytechnique Hauts-de-France (UPHF)-JUNIA (JUNIA), Institut de la matière condensée et des nanosciences / Institute of Condensed Matter and Nanosciences (IMCN), and Université Catholique de Louvain = Catholic University of Louvain (UCL)
Subjects: [SPI]Engineering Sciences [physics], General Materials Science, General Chemistry
Abstract: International audience; This work reports information on the transience of hole doping in epitaxial graphene devices when nitric acid is used as an adsorbent. Under vacuum conditions, desorption processes are monitored by electrical and spectroscopic means to extract the relevant timescales from the corresponding data. It is of vital importance to understand the reversible nature of hole doping because such device processing can be a suitable alternative to large-scale, metallic gating. Most measurements are performed post-exposure at room temperature, and, for some electrical transport measurements, at 1.5 K. Vacuum conditions are applied to many measurements to replicate the laboratory conditions under which devices using this doping method would be measured. The relevant timescales from transport measurements are compared with results from X-ray photoelectron spectroscopy and Fourier transform infrared spectroscopy measurements, with the latter performed at ambient conditions and accompanied by calculations of the spectra in the Reststrahlen band.
Published: 2022

45. Radioisotopic dating (U-Th, U-Pb) and palaeodosimetric (ESR) of the earliest prehistoric sites in Alpes-Maritimes: Vallonnet Cave, Terra Amata open air site, Lazaret Cave

Author: Michel, Véronique, Shen, Guanjun, Shen, Chuan-Chou, Duval, Mathieu, Woodhead, Jon, Chou, Yu-Min, Hu, Hsun-Ming, Wu, Chung-Che, Kan, Yu-Chun, Yang, Huihui, Yu, Tsai-Luen, Gallet, Sylvain, Valensi, Patricia, Culture et Environnements, Préhistoire, Antiquité, Moyen-Age (CEPAM), Université Nice Sophia Antipolis (1965 - 2019) (UNS), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Géoazur (GEOAZUR 7329), Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire de la Côte d'Azur, COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD [France-Sud]), College of Geographical Sciences, Nanjing Normal University (NNU), High-Precision Mass Spectrometry and Environment Change Laboratory (HISPEC), National Taiwan University [Taiwan] (NTU), Centro Nacional de Investigación sobre la Evolución Humana (CENIEH), School of Earth Sciences, University of Melbourne, CMM, Southern University of Science and Technology, 518055 Shenzhen, College of Marine Sciences and Engineering, Nanjing Normal University, Nanjing Jiangsu, Histoire naturelle de l'Homme préhistorique (HNHP), and Muséum national d'Histoire naturelle (MNHN)-Université de Perpignan Via Domitia (UPVD)-Centre National de la Recherche Scientifique (CNRS)
Subjects: [SHS.ARCHEO]Humanities and Social Sciences/Archaeology and Prehistory, Hominins, U-Pb, U-Th, Lower-Middle Palaeolithic, dating, ESR
Abstract: International audience; The extreme southeast of France contains Lower Palaeolithic sites and is a pivotal region for enhancing our understanding of the behaviour and lifestyle of the oldest hominins in Western Europe. Several dating programs have been carried out on the three main prehistoric sites in the Alpes-Maritimes region. Vallonnet Cave, the oldest site, at Roquebrune-Cap-Martin (43°45’51 “N 7°28’15 “E), yielded archaic tools associated with Epivillafranchian fauna. Some of the bones bear clear cut marks. The latest dates 1.18-1.22 Ma obtained by the U-Pb method are presented here. The site was occupied by hominins during the Cobb Mountain palaeomagnetic event, i.e., during MIS 36-35 (MIS: marine isotope stage). Palaeontological and palynological data indicate a cool dry climate at the base of the archaeological sequence followed by a temperate wet climate. Human occupations are recorded in the region at the open-air site of Terra Amata in Nice (43°41’52’’N, 7°17’21’’E), formerly dated to ca. 380 ka by ESR (Yokoyama et al., 1985) and biochronology, placing the occupations in the temperate MIS 11. H. erectus sporadically occupied the site during the warm season and left behind a Lower Palaeolithic industry described as Acheulean. Finally, groups of the last known Homo erectus repeatedly occupied Lazaret Cave in Nice (43°41’25’’N, 7°17’42’’E). The archaeological deposits have yielded a Final Acheulean industry, associated with faunal remains bearing numerous anthropic marks and nearly thirty human remains. The fauna indicates a cool and humid climate, attributed to MIS 6. The latest dates, obtained by ESR, U-Th and palaeomagnetic methods on the Pleistocene levels of the site, are presented here and chronologically position the archaeological levels between 190 ka and 120 ka.; L’extrême sud-est de la France renferme d’importants sites du Paléolithique inférieur. Ils permettent de mieux appréhender le comportement et le mode de vie des plus anciens hominines d’Europe occidentale. Différents programmes de datations ont été réalisés sur les trois principaux sites préhistoriques des Alpes-Maritimes. La grotte du Vallonnet, le plus ancien des sites de la région, à Roquebrune-Cap-Martin (43°45’51”N, 7°28’15”E), a livré des outils archaïques de culture oldowayenne associés à des faunes épivillafranchiennes et dont certains ossements portent des marques évidentes de découpe. Les dernières datations à 1,22-1,18 Ma obtenues par la méthode U-Pb sont présentées ici. L’occupation humaine du site se situe au cours de l’épisode paléomagnétiqueCobb Mountain soit au cours du stade isotopique marin MIS 36-35 (MIS: marine isotope stage), avec un climat frais et sec à labase de la séquence archéologique suivi d’un climat tempéré et humide d’après les données de la paléontologie et de la palynologie.D’autres occupations humaines plus tardives sont enregistrées dans la région, avec la présence de populations hominines sur le site de plein air de Terra Amata à Nice (43°41’52’’N, 7°17’21’’E), dont nous rappelons ici l’ancienne datation par ESR à environ 380 ka (Yokoyama et al., 1985) et les résultats de la biochronologie situant les occupations au cours de la période tempérée du MIS 11. Les Homo erectus ont occupé le site à plusieurs reprises, à la belle saison, et y ont laissé une industrie du Paléolithique inférieur rapportée à l’Acheuléen. Enfin, des groupes des derniers Homo erectus occupent de façon répétitive la grotte du Lazaret à Nice (43°41’25’’N,7°17’42’’E). Les dépôts archéologiques ont livré une industrie de l’Acheuléen final, associée à des restes fauniques portant de nombreuses marques anthropiques et près d’une trentaine de restes humains. La faune indique un climat frais et humide, au cours du stade MIS 6. Les dernières datations, présentées ici et obtenues par les méthodes ESR, U-Th et par le paléomagnétisme sur les niveaux pléistocènes du site, permettent de situer chronologiquement les niveaux archéologiques entre 190 ka et 120 ka
Published: 2022

46. The IEEE SSCI 2011 Human vs. Computer Go Competition

Author: Shi-Jim Yen, Hassen Doghmen, Cheng-Wei Chou, Olivier Teytaud, Chang-Shing Lee, National Dong Hwa University (NDHU), OASE, Institute of Computer Science and Information Engineering [Taiwan] (Institute of CSIE), National Taiwan University [Taiwan] (NTU)-National Taiwan University [Taiwan] (NTU), Machine Learning and Optimisation (TAO), Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)-Université Paris-Sud - Paris 11 (UP11)-Laboratoire de Recherche en Informatique (LRI), Université Paris-Sud - Paris 11 (UP11)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-CentraleSupélec, Laboratoire de Recherche en Informatique (LRI), Université Paris-Sud - Paris 11 (UP11)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-Université Paris-Sud - Paris 11 (UP11)-CentraleSupélec-Centre National de la Recherche Scientifique (CNRS)-Inria Saclay - Ile de France, and Institut National de Recherche en Informatique et en Automatique (Inria)-Institut National de Recherche en Informatique et en Automatique (Inria)
Subjects: business.industry, Computer science, Computational Mechanics, 0102 computer and information sciences, 02 engineering and technology, 01 natural sciences, Computer Graphics and Computer-Aided Design, Human-Computer Interaction, World Wide Web, Competition (economics), 010201 computation theory & mathematics, 0202 electrical engineering, electronic engineering, information engineering, Computer Science (miscellaneous), Table (database), 020201 artificial intelligence & image processing, [MATH.MATH-OC]Mathematics [math]/Optimization and Control [math.OC], Artificial intelligence, business, Computer Go, ComputingMilieux_MISCELLANEOUS
Abstract: th to 14 th 2011 at Paris, France. There were several games in this competition, including 13x13 Go, 19x19 Go, Blind Go, and Random Go games. This report focuses on 13x13 Go and 19x19 Go. For Blind Go and Random Go, please refer to the report by Yen et al. (2011). The human participants Chun-Hsun Chou and PingChiang Chou are brothers. They both are professional Go Players. Table 1 shows information on the human participants. Table 2 shows information of the two computer Go programs, MOGO and PACHI.
Published: 2011

47. Local Uses of Geographical Knowledge in Imperial China

Author: Lycas, Alexis, Hasegawa, Masato, Chen, Shih-Pei, Centre de recherche sur les civilisations de l'Asie Orientale (CRCAO), Collège de France (CdF (institution))-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL), National Taiwan University [Taiwan] (NTU), Max Planck Institute for the History of Science (MPIWG), and Max-Planck-Gesellschaft
Subjects: [SHS.HISPHILSO]Humanities and Social Sciences/History, Philosophy and Sociology of Sciences, [SHS.GEO]Humanities and Social Sciences/Geography, [SHS.HIST]Humanities and Social Sciences/History, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2021

48. Local Uses of Geographical Knowledge in Imperial China

Author: Lycas, Alexis, Masato 長谷川正人, Hasegawa, Shih-Pei 陳詩沛, Chen, Centre de recherche sur les civilisations de l'Asie Orientale (CRCAO), Collège de France (CdF (institution))-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL), École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL), National Taiwan University [Taiwan] (NTU), Max Planck Institute for the History of Science (MPIWG), and Max-Planck-Gesellschaft
Subjects: [SHS.HISPHILSO]Humanities and Social Sciences/History, Philosophy and Sociology of Sciences, [SHS.GEO]Humanities and Social Sciences/Geography, [SHS.HIST]Humanities and Social Sciences/History, ComputingMilieux_MISCELLANEOUS
Abstract: International audience
Published: 2021

49. Transgenic refractory Aedes aegypti lines are resistant to multiple serotypes of dengue virus

Author: Wei-Liang Liu, Chia-Wei Hsu, Shih-Peng Chan, Pei-Shi Yen, Matthew P. Su, Jian-Chiuan Li, Hsing-Han Li, Lie Cheng, Cheng-Kang Tang, Shih-Hsun Ko, Huai-Kuang Tsai, Zing Tsung-Yeh Tsai, Omar S. Akbari, Anna-Bella Failloux, Chun-Hong Chen, National Health Research Institutes [Taiwan] (NHRI), National Taiwan University [Taiwan] (NTU), Arbovirus et Insectes Vecteurs - Arboviruses and Insect Vectors, Institut Pasteur [Paris] (IP)-Université Paris Cité (UPCité), Nagoya University, Academia Sinica, University of California [San Diego] (UC San Diego), University of California (UC), and This study also was supported by the National Health Research Institutes (NHRI), Taiwan (Grant No. NHRI-MR-110-GP-12) and Ministry of Health and Welfare (Grant No. MOHW103-TDU-B-212-000005) awarded to Chun-Hong Chen.
Subjects: Mosquito Control, [SDV]Life Sciences [q-bio], viruses, MESH: Cricetinae, Transposases, MESH: Dengue, Pathogenesis, MESH: Dengue Virus, Dengue, MESH: Cricetulus, Aedes, Cricetinae, MESH: RNA, Small Interfering, 2.2 Factors relating to the physical environment, MESH: Animals, Aetiology, MESH: Mosquito Control, Multidisciplinary, virus diseases, MESH: Aedes, Viral Load, Infectious Diseases, Medicine, MESH: Mosquito Vectors, MESH: Viral Load, Infection, Biotechnology, Science, Genetically Modified, Mosquito Vectors, Small Interfering, Serogroup, Article, Cell Line, MESH: Animals, Genetically Modified, Vaccine Related, Cricetulus, Rare Diseases, Biodefense, Genetics, Animals, Prevention, MESH: Serogroup, Fibroblasts, Dengue Virus, MESH: Cell Line, Vector-Borne Diseases, Emerging Infectious Diseases, Good Health and Well Being, MESH: Fibroblasts, RNAi, MESH: Transposases, RNA
Abstract: The areas where dengue virus (DENV) is endemic have expanded rapidly, driven in part by the global spread of Aedes species, which act as disease vectors. DENV replicates in the mosquito midgut and is disseminated to the mosquito’s salivary glands for amplification. Thus, blocking virus infection or replication in the tissues of the mosquito may be a viable strategy for reducing the incidence of DENV transmission to humans. Here we used the mariner Mos1 transposase to create an Aedes aegypti line that expresses virus-specific miRNA hairpins capable of blocking DENV replication. These microRNA are driven by the blood-meal-inducible carboxypeptidase A promoter or by the polyubiquitin promoter. The transgenic mosquitoes exhibited significantly lower infection rates and viral titers for most DENV serotypes 7 days after receiving an infectious blood meal. The treatment was also effective at day 14 post infection after a second blood meal had been administered. In viral transmission assay, we found there was significantly reduced transmission in these lines. These transgenic mosquitoes were effective in silencing most of the DENV genome; such an approach may be employed to control a dengue fever epidemic.
Published: 2021

50. Surface Functionalization Strategies of Polystyrene for the Development Peptide-Based Toxin Recognition

Author: Ahmed M. Debela, Catherine Gonzalez, Monica Pucci, Shemsia M. Hudie, Ingrid Bazin, IMT Mines Alès - ERT (ERT), IMT - MINES ALES (IMT - MINES ALES), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Hydrosciences Montpellier (HSM), Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Durabilité des éco-Matériaux et Structures (DMS), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT)-Laboratoire de Mécanique et Génie Civil (LMGC), Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), and National Taiwan University [Taiwan] (NTU)
Subjects: [SDV.BIO]Life Sciences [q-bio]/Biotechnology, polystyrene, surface modification, coupling agents, ochratoxin A, food monitoring, water monitoring, Biosensing Techniques, Ligands, Biochemistry, Atomic and Molecular Physics, and Optics, Analytical Chemistry, [CHIM.POLY]Chemical Sciences/Polymers, [SDV.TOX]Life Sciences [q-bio]/Toxicology, [SDV.IDA]Life Sciences [q-bio]/Food engineering, Polystyrenes, Electrical and Electronic Engineering, Peptides, Instrumentation, Horseradish Peroxidase
Abstract: International audience; The development of a robust surface functionalization method is indispensable in controlling the efficiency, sensitivity, and stability of a detection system. Polystyrene (PS) has been used as a support material in various biomedical fields. Here, we report various strategies of polystyrene surface functionalization using siloxane derivative, divinyl sulfone, cyanogen bromide, and carbonyl diimidazole for the immobilization of biological recognition elements (peptide developed to detect ochratoxin A) for a binding assay with ochratoxin A (OTA). Our objective is to develop future detection systems that would use polystyrene cuvettes such as immobilization support of biological recognition elements. The goal of this article is to demonstrate the proof of concept of this immobilization support. The results obtained reveal the successful modification of polystyrene surfaces with the coupling agents. Furthermore, the immobilization of biological recognition elements, for the OTA binding assay with horseradish peroxidase conjugated to ochratoxin A (OTA-HRP) also confirms that the characteristics of the functionalized peptide immobilized on polystyrene retains its ability to bind to its ligand. The presented strategies on the functionalization of polystyrene surfaces will offer alternatives to the possibilities of immobilizing biomolecules with excellent order- forming monolayers, due to their robust surface chemistries and validate a proof of concept for the development of highly efficient, sensitive, and stable future biosensors for food or water pollution monitoring.
Published: 2022

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