61 results on '"Nathan P Miller"'
Search Results
2. Community health systems: allowing community health workers to emerge from the shadows
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Jerome Pfaffmann Zambruni, Kumanan Rasanathan, David Hipgrave, Nathan P Miller, Maureen Momanyi, Luwei Pearson, Dolores Rio, Magali Romedenne, Sagri Singh, Mark Young, and Stefan Peterson
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Public aspects of medicine ,RA1-1270 - Published
- 2017
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3. Assessing the Quality of Sick Child Care Provided by Community Health Workers.
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Nathan P Miller, Agbessi Amouzou, Elizabeth Hazel, Tedbabe Degefie, Hailemariam Legesse, Mengistu Tafesse, Luwei Pearson, Robert E Black, and Jennifer Bryce
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Medicine ,Science - Abstract
As community case management of childhood illness expands in low-income countries, there is a need to assess the quality of care provided by community health workers. This study had the following objectives: 1) examine methods of recruitment of sick children for assessment of quality of care, 2) assess the validity of register review (RR) and direct observation only (DO) compared to direct observation with re-examination (DO+RE), and 3) assess the effect of observation on community health worker performance.We conducted a survey to assess the quality of care provided by Ethiopian Health Extension Workers (HEWs). The sample of children was obtained through spontaneous consultation, HEW mobilization, or recruitment by the survey team. We assessed patient characteristics by recruitment method. Estimates of indicators of quality of care obtained using RR and DO were compared to gold standard estimates obtained through DO+RE. Sensitivity, specificity, and the area under receiver operator characteristic curve (AUC) were calculated to assess the validity of RR and DO. To assess the Hawthorne effect, we compared estimates from RR for children who were observed by the survey team to estimates from RR for children who were not observed by the survey team.Participants included 137 HEWs and 257 sick children in 103 health posts, plus 544 children from patient registers. Children mobilized by HEWs had the highest proportion of severe illness (27%). Indicators of quality of care from RR and DO had high sensitivity for most indicators, but specificity was low. The AUC for different indicators from RR ranged from 0.47 to 0.76, with only one indicator above 0.75. The AUC of indicators from DO ranged from 0.54 to 1.0, with three indicators above 0.75. The differences between estimates of correct care for observed versus not observed children were small.Mobilization by HEWs and recruitment by the survey teams were feasible, but potentially biased, methods of obtaining sick children. Register review and DO underestimated performance errors. Our data suggest that being observed had only a small positive effect on the performance of HEWs.
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- 2015
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4. Mineral, seed morphology, and agronomic characteristics of proso millet grown in the inland Pacific Northwest
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Tayler Reinman, Jessica Braden, Nathan Daniel Miller, and Kevin M. Murphy
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nutritional characteristics ,end-use characteristics ,underutilized crops ,crop diversity ,variety trials ,climate resilience ,Nutrition. Foods and food supply ,TX341-641 - Abstract
Climate change increases stressors that will challenge the resiliency of global agricultural production. Just three crops, wheat, maize, and rice, are estimated to sustain 50% of the caloric demand of the world population, meaning that significant loss of any of these crops would threaten global food security. However, increasing cropping system diversity can create a more resilient food system. One crop that could add diversity to wheat-dominated cropping systems in the inland Pacific Northwest is proso millet, a climate-resilient, small-seeded cereal crop that is highly water efficient, able to grow in low fertility soils, and has a desirable nutritional profile. Proso millet shows potential for adoption in this region due to its short growing season, compatibility with regional equipment, and environmental requirements, however US cultivars have been developed for the Great Plains and little research has been conducted outside of this region. To better understand the potential for adoption in the inland PNW, seven commercially available varieties were planted in a researcher-run trial in Pullman, WA and in a series of producer-run trials across the region in 2022. Samples were analyzed for mineral concentration (Zn, Fe, Cu, Mn, Mg, Ca, P, and K), seed morphology phenotypes (seed area, seed eccentricity, thousand seed weight, and seed color), and agronomic phenotypes (grain yield, plant height, days to heading, days to maturity, and percent emergence). Varieties from the researcher-run trial showed significant differences for all traits excluding percent emergence. Samples from producer-run trials showed differences by location for concentration of all minerals and for all seed morphology traits but were not analyzed for agronomic phenotypes. Samples from producer-run trials showed no difference by variety for mineral concentration but showed varietal differences for all seed morphology phenotypes. Most minerals were positively correlated with one another (0.28
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- 2024
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5. QTL for the Kinematic Traits That Define the Arabidopsis Root Elongation Zone and Their Relationship to Gravitropism
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Ashley R. Henry, Nathan D. Miller, and Edgar P. Spalding
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cell expansion ,root growth ,elongation zone ,kinematics ,QTL ,Botany ,QK1-989 - Abstract
Cell expansion in a discrete region called the elongation zone drives root elongation. Analyzing time lapse images can quantify the expansion in kinematic terms as if it were fluid flow. We used horizontal microscopes to collect images from which custom software extracted the length of the elongation zone, the peak relative elemental growth rate (REGR) within it, the axial position of the REGR peak, and the root elongation rate. Automation enabled these kinematic traits to be measured in 1575 Arabidopsis seedlings representing 162 recombinant inbred lines (RILs) derived from a cross of Cvi and Ler ecotypes. We mapped ten quantitative trait loci (QTL), affecting the four kinematic traits. Three QTL affected two or more traits in these vertically oriented seedlings. We compared this genetic architecture with that previously determined for gravitropism using the same RIL population. The major QTL peaks for the kinematic traits did not overlap with the gravitropism QTL. Furthermore, no single kinematic trait correlated with quantitative descriptors of the gravitropism response curve across this population. In addition to mapping QTL for growth zone traits, this study showed that the size and shape of the elongation zone may vary widely without affecting the differential growth induced by gravity.
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- 2024
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6. Evaluating relationships between seed morphological traits and seed dormancy in Chenopodium quinoa Willd.
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Emma M. McGinty, Evan B. Craine, Nathan D. Miller, Cristina Ocana-Gallegos, Edgar P. Spalding, Kevin M. Murphy, and Amber L. Hauvermale
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Chenopodium quinoa Willd. ,preharvest sprout (PHS) ,seed dormancy ,morphological traits ,agronomic traits ,phenetic modeling ,Plant culture ,SB1-1110 - Abstract
IntroductionQuinoa is a high-value, nutritious crop that performs well in variable environments, marginal soils, and in diverse crop rotations. Quinoa’s many attributes make it an ideal crop for supporting human health in global communities and economies. To date, quinoa research has largely focused on traits in adult plants important for enhancing plant phenotypic plasticity, abiotic stress, disease resistance, and yield. Fewer studies have evaluated quinoa seed dormancy and suggest that most modern quinoa varieties have weak or no seed dormancy, and a narrow window of seed viability post-harvest. In other crops, diminished seed dormancy is a major risk factor for preharvest sprouting (PHS; germination on the panicle due to rain prior to harvest) and may also pose a similar risk for quinoa.MethodsThis study (1) developed a dormancy screening assay to characterize seed dormancy strength in a large collection of quinoa varieties, (2) investigated if morphological variables including seed coat color, seed coat thickness, seed shape including eccentricity which evaluates the roundness or flatness of a seed, and other agronomic traits like crude protein content and seed moisture, contribute to quinoa seed dormancy, and (3) evaluated the use of a phenetic modeling approach to explore relationships between seed morphology and seed dormancy.ResultsDormancy screening indicated seed dormancy ranges in quinoa varieties from none to strong dormancy. Further, phenetic modeling approaches indicate that seed coat thickness and eccentricity are important morphological variables that impact quinoa seed dormancy strength.ConclusionsWhile dormancy screening and phenetic modeling approaches do not provide a direct solution to preventing PHS in quinoa, they do provide new tools for identifying dormant varieties as well as morphological variables contributing to seed dormancy.
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- 2023
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7. Revealing global risks of labor abuse and illegal, unreported, and unregulated fishing
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Elizabeth R. Selig, Shinnosuke Nakayama, Colette C. C. Wabnitz, Henrik Österblom, Jessica Spijkers, Nathan A. Miller, Jan Bebbington, and Jessica L. Decker Sparks
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Science - Abstract
Taking action to reduce risks of labor abuse and illegal, unreported, and unregulated (IUU) fishing in the fishing sector is hindered by a lack of spatially explicit data and an understanding of different drivers of risks. Here the authors combine expert assessments with satellite information to map and quantify risks of labor abuse and IUU fishing at port, at sea and associated with transshipment globally.
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- 2022
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8. A comprehensive characterization of agronomic and end-use quality phenotypes across a quinoa world core collection
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Evan B. Craine, Alathea Davies, Daniel Packer, Nathan D. Miller, Sandra M. Schmöckel, Edgar P. Spalding, Mark Tester, and Kevin M. Murphy
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quinoa ,plant breeding ,protein ,amino acids ,high-throughput phenotyping ,Plant culture ,SB1-1110 - Abstract
Quinoa (Chenopodium quinoa Willd.), a pseudocereal with high protein quality originating from the Andean region of South America, has broad genetic variation and adaptability to diverse agroecological conditions, contributing to the potential to serve as a global keystone protein crop in a changing climate. However, the germplasm resources currently available to facilitate quinoa expansion worldwide are restricted to a small portion of quinoa’s total genetic diversity, in part because of day-length sensitivity and issues related to seed sovereignty. This study aimed to characterize phenotypic relationships and variation within a quinoa world core collection. The 360 accessions were planted in a randomized complete block design with four replicates in each of two greenhouses in Pullman, WA during the summer of 2018. Phenological stages, plant height, and inflorescence characteristics were recorded. Seed yield, composition, thousand seed weight, nutritional composition, shape, size, and color were measured using a high-throughput phenotyping pipeline. Considerable variation existed among the germplasm. Crude protein content ranged from 11.24% to 17.81% (fixed at 14% moisture). We found that protein content was negatively correlated with yield and positively correlated with total amino acid content and days to harvest. Mean essential amino acids values met adult daily requirements but not leucine and lysine infant requirements. Yield was positively correlated with thousand seed weight and seed area, and negatively correlated with ash content and days to harvest. The accessions clustered into four groups, with one-group representing useful accessions for long-day breeding programs. The results of this study establish a practical resource for plant breeders to leverage as they strategically develop germplasm in support of the global expansion of quinoa.
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- 2023
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9. Inferring habitat use of the Pacific White Shark using vertebral chemistry
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John A. Mohan, Alfonsina E. Romo-Curiel, Sharon Z. Herzka, R. J. David Wells, Nathan R. Miller, Oscar Sosa-Nishizaki, and Emiliano García-Rodríguez
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White Shark (Carcharodon carcharias) ,stable isotope ,trace elements ,vertebrae ,migration ,Pacific Ocean (Northeast) ,Science ,General. Including nature conservation, geographical distribution ,QH1-199.5 - Abstract
The conservation and management of highly migratory sharks relies on understanding age-related movements and nursery habitat utilization. We reconstructed the habitat use and migratory history of young White Sharks (Carcharodon carcharias), a highly protected species, by utilizing natural chemical tracers (element:Ca ratios and stable isotope analysis, SIA) in vertebral cartilage growth bands. Two nursery areas in the northeastern Pacific are known, but migration patterns of immature White Sharks within the Gulf of California (GC) and natal philopatry are poorly understood. Vertebrae from coastal Mexican artisanal fisheries off central Baja California in the Pacific (12 neonates and juveniles; 139-280 cm total length) and the GC (3 subadults; 289-355 cm TL) were analyzed to characterize (1) trophic histories from collagen δ13C and δ15N values, and (2) in utero patterns and post-birth environmental histories from element:Ca time-series. Mean δ15N values from vertebral edges of GC sharks, representing the most recent feeding, was +5‰ higher than in the Pacific, reflecting the intense denitrification that permeates the regional food web and supporting SIA as tracers of migration between regions. A subadult from the GC likely resided within the system throughout its life, and two subadults migrated into the GC. Most neonate and juvenile sharks caught in the Pacific had SIA that did not overlap with those of the GC, but a single subadult likely migrated to the GC. Element:Ca ratios displayed ontogenetic trends, with Li:Ca, Zn:Ca, and Ba:Ca significantly higher before the birth mark in sharks captured in the GC. Edge values were significantly higher in Zn:Ca and Ba:Ca in the GC compared to the Pacific, suggesting elemental ratios may serve as tracers of migration between regions. Subadult sharks collected from GC displayed elevated maternal Zn:Ca and Ba:Ca, suggesting mothers may have resided in the GC for an extensive period pre-birth. Some White Sharks may reside within the GC from birth until at least the subadult stage (ca. 3 m TL), and there may be an unidentified nursery. Chemical tracers, coupled with genomic and tagging studies, should improve understanding of the importance of the GC to White Shark populations in the northeast Pacific.
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- 2023
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10. Automated VIIRS Boat Detection Based on Machine Learning and Its Application to Monitoring Fisheries in the East China Sea
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Masaki E. Tsuda, Nathan A. Miller, Rui Saito, Jaeyoon Park, and Yoshioki Oozeki
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VIIRS nightlight ,VIIRS boat detection ,machine learning ,Science - Abstract
Remote sensing is essential for monitoring fisheries. Optical sensors such as the day–night band (DNB) of the Visible Infrared Imaging Radiometer Suite (VIIRS) have been a crucial tool for detecting vessels fishing at night. It remains challenging to ensure stable detections under various conditions affected by the clouds and the moon. Here, we develop a machine learning based algorithm to generate automatic and consistent vessel detection. As DNB data are large and highly imbalanced, we design a two-step approach to train our model. We evaluate its performance using independent vessel position data acquired from on-ship radar. We find that our algorithm demonstrates comparable performance to the existing VIIRS boat detection algorithms, suggesting its possible application to greater temporal and spatial scales. By applying our algorithm to the East China Sea as a case study, we reveal a recent increase in fishing activity by vessels using bright lights. Our VIIRS boat detection results aim to provide objective information for better stock assessment and management of fisheries.
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- 2023
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11. CLASS Data Pipeline and Maps for 40 GHz Observations through 2022
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Yunyang Li, Joseph R. Eimer, Keisuke Osumi, John W. Appel, Michael K. Brewer, Aamir Ali, Charles L. Bennett, Sarah Marie Bruno, Ricardo Bustos, David T. Chuss, Joseph Cleary, Jullianna Denes Couto, Sumit Dahal, Rahul Datta, Kevin L. Denis, Rolando Dünner, Francisco Espinoza, Thomas Essinger-Hileman, Pedro Fluxá Rojas, Kathleen Harrington, Jeffrey Iuliano, John Karakla, Tobias A. Marriage, Nathan J. Miller, Sasha Novack, Carolina Núñez, Matthew A. Petroff, Rodrigo A. Reeves, Karwan Rostem, Rui Shi, Deniz A. N. Valle, Duncan J. Watts, Janet L. Weiland, Edward J. Wollack, Zhilei Xu, Lingzhen Zeng, and CLASS Collaboration
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Astronomy data analysis ,Cosmic microwave background radiation ,Observational cosmology ,Early universe ,Astrophysics ,QB460-466 - Abstract
The Cosmology Large Angular Scale Surveyor (CLASS) is a telescope array that observes the cosmic microwave background over 75% of the sky from the Atacama Desert, Chile, at frequency bands centered near 40, 90, 150, and 220 GHz. This paper describes the CLASS data pipeline and maps for 40 GHz observations conducted from 2016 August to 2022 May. We demonstrate how well the CLASS survey strategy, with rapid (∼10 Hz) front-end modulation, recovers the large-scale Galactic polarization signal from the ground: the mapping transfer function recovers ∼67% (85%) of EE and BB ( VV ) power at ℓ = 20 and ∼35% (47%) at ℓ = 10. We present linear and circular polarization maps over 75% of the sky. Simulations based on the data imply the maps have a white noise level of $110\,\mu {\rm{K}}\,\mathrm{arcmin}$ and correlated noise component rising at low- ℓ as ℓ ^−2.4 . The transfer-function-corrected low- ℓ component is comparable to the white noise at the angular knee frequencies of ℓ ≈ 18 (linear polarization) and ℓ ≈ 12 (circular polarization). Finally, we present simulations of the level at which expected sources of systematic error bias the measurements, finding subpercent bias for the Λ cold dark matter EE power spectra. Bias from E -to- B leakage due to the data reduction pipeline and polarization angle uncertainty approaches the expected level for an r = 0.01 BB power spectrum. Improvements to the instrument calibration and the data pipeline will decrease this bias.
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- 2023
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12. Testing Cosmic Microwave Background Anomalies in E-mode Polarization with Current and Future Data
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Rui Shi, Tobias A. Marriage, John W. Appel, Charles L. Bennett, David T. Chuss, Joseph Cleary, Joseph R. Eimer, Sumit Dahal, Rahul Datta, Francisco Espinoza, Yunyang Li, Nathan J. Miller, Carolina Núñez, Ivan L. Padilla, Matthew A. Petroff, Deniz A. N. Valle, Edward J. Wollack, and Zhilei Xu
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Cosmic microwave background radiation ,Early universe ,Observational cosmology ,Astrophysics ,QB460-466 - Abstract
In this paper, we explore the power of the cosmic microwave background (CMB) polarization ( E -mode) data to corroborate four potential anomalies in CMB temperature data: the lack of large angular-scale correlations, the alignment of the quadrupole and octupole (Q–O), the point-parity asymmetry, and the hemispherical power asymmetry. We use CMB simulations with noise representative of three experiments—the Planck satellite, the Cosmology Large Angular Scale Surveyor (CLASS), and the LiteBIRD satellite—to test how current and future data constrain the anomalies. We find the correlation coefficients ρ between temperature and E -mode estimators to be less than 0.1, except for the point-parity asymmetry ( ρ = 0.17 for cosmic-variance-limited simulations), confirming that E -modes provide a check on the anomalies that is largely independent of temperature data. Compared to Planck component-separated CMB data ( smica ), the putative LiteBIRD survey would reduce errors on E -mode anomaly estimators by factors of ∼3 for hemispherical power asymmetry and point-parity asymmetry, and by ∼26 for lack of large-scale correlation. The improvement in Q–O alignment is not obvious due to large cosmic variance, but we found the ability to pin down the estimator value will be improved by a factor ≳100. Improvements with CLASS are intermediate to these.
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- 2023
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13. A machine vision platform for measuring imbibition of maize kernels: quantification of genetic effects and correlations with germination
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Nathan D. Miller, Scott C. Stelpflug, Shawn M. Kaeppler, and Edgar P. Spalding
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Germination ,High-throughput phenotyping ,Imbibition ,Image analysis ,Machine vision ,Zea mays ,Plant culture ,SB1-1110 ,Biology (General) ,QH301-705.5 - Abstract
Abstract Background Imbibition (uptake of water by a dry seed) initiates the germination process. An automated method for quantifying imbibition would enable research on the genetic elements that influence the underlying hydraulic and biochemical processes. In the case of crop research, a high throughput imbibition assay could be used to investigate seed quality topics or to improve yield by selecting varieties with superior germination characteristics. Results An electronic force transducer measured imbibition of single maize kernels with very high resolution but low throughput. An image analysis method was devised to achieve high throughput and sufficient resolution. A transparent fixture held 90 maize kernels in contact with water on the imaging window of a flatbed document scanner that produced an image of the kernels automatically every 10 min for 22 h. Custom image analysis software measured the area A of each indexed kernel in each image to produce imbibition time courses. The ultimate change in area (ΔA) ranged from 19.3 to 23.4% in a population of 72 hybrids derived from 9 inbred parents. Kernel area as a function of time was fit well by $$A\left( t \right) = A_{f} \left( {1 - e^{ - kt} } \right)$$ At=Af1-e-kt where A f is the final kernel area. The swelling coefficient, k, ranged from 0.098 to 0.159 h−1 across the genotypes. The full diallel structure of the population enabled maternal genotype effects to be assessed. In a separate experiment, measurements of kernels of the same 25 inbreds produced in three different years demonstrated that production and storage variables affected imbibition much less than genotype. In a third experiment, measurements of 30 diverse inbred lines showed that k varied inversely with germination time (r = − 0.7) and directly with germination percentage (r = 0.7). Conclusions Nonspecialized imaging hardware and custom analysis software running on public cyber infrastructure form a low-cost platform for measuring seed imbibition with high resolution and throughput. We measured imbibition of thousands of kernels to determine that genotype influenced imbibition of maize kernels much more than seed production and storage environments. In some hybrids, k depended on which inbred parent was maternal. Quantitative relationships between k and germination traits were discovered.
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- 2018
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14. Identifying Global Patterns of Transshipment Behavior
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Nathan A. Miller, Aaron Roan, Timothy Hochberg, John Amos, and David A. Kroodsma
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fisheries ,transshipment ,refrigerated cargo vessel ,IUU fishing ,reefer ,Science ,General. Including nature conservation, geographical distribution ,QH1-199.5 - Abstract
Transshipment at sea, the offloading of catch from a fishing vessel to a refrigerated vessel far from port, can obscure the actual source of the catch, complicating sustainable fisheries management, and may allow illegally caught fish to enter the legitimate seafood market. Transshipment activities often occur in regions of unclear jurisdiction where policymakers or enforcement agencies may be slow to act against a challenge they cannot see. To address this limitation, we processed 32 billion Automatic Identification System (AIS) messages from ocean-going vessels from 2012 to the end of 2017 and identified and tracked 694 cargo vessels capable of transshipping at sea and transporting fish (referred to as transshipment vessels). We mapped 46,570 instances where these vessels loitered at sea long enough to receive a transshipment and 10,233 instances where we see a fishing vessel near a loitering transshipment vessel long enough to engage in transshipment. We found transshipment behaviors associated with regions and flag states exhibiting limited oversight; roughly 47% of the events occur on the high seas and 42% involve vessels flying flags of convenience. Transshipment behavior in the high seas is relatively common, with vessels responsible for 40% of the fishing in the high seas having at least one encounter with a transshipment vessel in this time period. Our analysis reveals that addressing the sustainability and human rights challenges (slavery, trafficking, bonded labor) associated with transshipment at sea will require a global perspective and transnational cooperation.
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- 2018
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15. The contribution of community health systems to resilience: Case study of the response to the drought in Ethiopia
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Angeli, Rawat, Jonas, Karlstrom, Agazi, Ameha, Macoura, Oulare, Mohamed Diaaeldin, Omer, Hentsa Haddush, Desta, Shalini, Bahuguna, Katrina, Hsu, Nathan P, Miller, Gemu Tiru, Bati, and Kumanan, Rasanathan
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Health Policy ,Public Health, Environmental and Occupational Health ,Humans ,Mothers ,Female ,Ethiopia ,Focus Groups ,Child ,Community Health Planning ,Droughts - Abstract
Ethiopia's exposure to the El Niño drought (2015-2016) resulted in high malnutrition, internally displaced people, and epidemics of communicable diseases, all of which strained the health system. The drought was especially challenging for mothers and children. We aimed to identify salient factors that can improve health system resilience by exploring the successes and challenges experienced by a community-based health system during the drought response.We collected data via key informant interviews and focus group discussions to capture diverse perspectives across the health system (eg, international, national, district, facility, and community perspectives). Data were collected from communities in drought-affected regions of: 1) Somali, Sitti Zone, 2) Hawassa, Southern Nations, Nationalities, and Peoples' Region (SNNPR), and 3) Tigray, Eastern Zone. Data were analysed using a deductive-inductive approach using thematic content analysis applied to a conceptual framework.A total of 94 participants were included (71 from the communities and 23 from other levels). Key themes included the importance of: 1) organized community groups linked to the health system, 2) an effective community health workforce within strong health systems, 3) adaptable human resource structures and service delivery models, 4) training and preparedness, and 5) strong government leadership with decentralized decision making.The results of this study provide insights from across the health system into the successes and challenges of building resilience in community-based health systems in Ethiopia during the drought. As climate change exacerbates extreme weather events, further research is needed to understand the determinants of building resilience from a variety of shocks in multiple contexts, especially focusing on harnessing the power of communities as reservoirs of resilience.
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- 2022
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16. Barriers to the utilization of community-based child and newborn health services in Ethiopia: a scoping review
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Sadaf Khan, Birkety Mengistu, Meron Paulos, Nesibu Agonafir, Sonya Stokes, Agazi Ameha, Farid Bagheri Ardestani, Bizuhan Gelaw Birhanu, Hayes Wong, Mariame Sylla, Nathan P Miller, and Ephrem Tekle Lemango
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Community education ,Service delivery framework ,030231 tropical medicine ,utilization ,Review ,03 medical and health sciences ,0302 clinical medicine ,Nursing ,Humans ,AcademicSubjects/MED00860 ,Family ,Community Health Services ,030212 general & internal medicine ,Child ,Care seeking ,community health ,Community Health Workers ,Service (business) ,newborn and child health ,Supply chain management ,Health Policy ,Infant, Newborn ,Subsidy ,Grey literature ,Intervention (law) ,Community health ,Female ,Ethiopia ,Business ,health systems ,Case Management - Abstract
The Ethiopian Federal Ministry of Health and partners have scaled up integrated community case management (iCCM) and community-based newborn care (CBNC), allowing health extension workers (HEWs) to manage the major causes of child and newborn death at the community level. However, low service uptake remains a key challenge. We conducted a scoping review of peer-reviewed and grey literature to assess barriers to the utilization of HEW services and to explore potential solutions. The review, which was conducted to inform the Optimizing the Health Extension Program project, which aimed to increase the utilization of iCCM and CBNC services, included 24 peer-reviewed articles and 18 grey literature documents. Demand-side barriers to utilization included lack of knowledge about the signs and symptoms of childhood illnesses and danger signs; low awareness of curative services offered by HEWs; preference for home-based care, traditional care, or religious intervention; distance, lack of transportation and cost of care seeking; the need to obtain husband’s permission to seek care and opposition of traditional or religious leaders. Supply-side barriers included health post closures, drug stockouts, disrespectful care and limited skill and confidence of HEWs, particularly with regard to the management of newborn illnesses. Potential solutions included community education and demand generation activities, finding ways to facilitate and subsidize transportation to health facilities, engaging family members and traditional and religious leaders, ensuring consistent availability of services at health posts and strengthening supervision and supply chain management. Both demand generation and improvement of service delivery are necessary to achieve the expected impact of iCCM and CBNC. Key steps for improving utilization would be carrying out multifaceted demand generation activities, ensuring availability of HEWs in health posts and ensuring consistent supplies of essential commodities. The Women’s Development Army has the potential to improving linkages between HEWs and communities, but this strategy needs to be strengthened to be effective.
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- 2021
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17. Speculations Linking Monazite Compositions to Origin: Llallagua Tin Ore Deposit (Bolivia)
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Elizabeth J. Catlos and Nathan R. Miller
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monazite ,rare earth elements ,geochemistry ,Bolivia ,apatite ,Llallagua ,Science - Abstract
Monazite [(Ce,Th)PO4] from the Llallagua tin ore deposit in Bolivia is characterized by low radiogenic element contents. Previously reported field evidence and mineral associations suggest the mineral formed via direct precipitation from hydrothermal fluids. Monazite compositions thus may provide insight into characteristics of the fluids from which it formed. Chemical compositions of three Llallagua monazite grains were obtained using Electron Probe Microanalysis (EPMA), n = 64] and laser ablation mass spectrometer (LA-ICP-MS, n = 56). The mineral has higher amounts of U (123 ± 17 ppm) than Th (39 ± 20 ppm) (LA-ICP-MS, ±1σ). Grains have the highest amounts of fluorine ever reported for monazite (0.88 ± 0.10 wt %, EPMA, ±1σ), and F-rich fluids are effective mobilizers of rare earth elements (REEs), Y, and Th. The monazite has high Eu contents and positive Eu anomalies, consistent with formation in a highly-reducing back-arc environment. We speculate that F, Ca, Si and REE may have been supplied via dissolution of pre-existing fluorapatite. Llallagua monazite oscillatory zoning is controlled by an interplay of low (P + Ca + Si + Y) and high atomic number (REE) elements. We suggest monazite compositions provide insight into fluid geochemistry, mineral reactions, and tectonic settings of ore deposits that contain the mineral.
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- 2017
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18. Community health workers in humanitarian settings: Scoping review
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Nureyan Zunong, Hannah Sarah Faich Dini, Fouzia Shafique, Farid Bagheri Ardestani, and Nathan P Miller
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Service delivery framework ,Supply chain ,030231 tropical medicine ,Population ,Psychological intervention ,Vulnerable Populations ,03 medical and health sciences ,0302 clinical medicine ,Humans ,030212 general & internal medicine ,Community Health Services ,education ,Poverty ,Community Health Workers ,education.field_of_study ,Data collection ,Primary Health Care ,business.industry ,Health Policy ,Public Health, Environmental and Occupational Health ,Grey literature ,Public relations ,Relief Work ,Work (electrical) ,Research Theme 2: Community Health in Emergencies ,Business ,Delivery of Health Care - Abstract
Background There is a need for greater understanding of experiences implementing community-based primary health care in humanitarian settings and of the adjustments needed to ensure continuation of essential services and utilization of services by the population, and to contribute to effective emergency response. We reviewed the evidence base on community health workers (CHWs) in humanitarian settings, with the goal of improving delivery of essential services to the most vulnerable populations. Methods We conducted a scoping review of published and grey literature related to health and nutrition services provided by CHWs in humanitarian settings. Extracted data from retained documents were analyzed inductively for key themes. Results Of 3709 documents screened, 219 were included in the review. Key findings from the literature include: 1) CHWs were often able to continue providing services during acute and protracted crises, including prolonged periods of conflict and insecurity and during population displacement. 2) CHWs carried out critical emergency response activities during acute crises. 3) Flexible funding facilitated transitions between development and humanitarian programming. 4) Communities that did not have a locally-resident CHW experienced reduced access to services when travel was limited. 5) Community selection of CHWs and engagement of respected local leaders were crucial for community trust and acceptance and high utilization of services. 6) Selection of local supervisors and use of mobile phones facilitated continued supervision. 7) Actions taken to maintain supplies included creating parallel supply chains, providing buffer stocks to CHWs, and storing commodities in decentralized locations. 8) When travel was restricted, reporting and data collection were continued using mobile phones and use of local data collectors. 9) CHWs and supervisors faced security threats and psychological trauma as a result of their work. Conclusions To achieve impact, policy makers and program implementers will have to address the bottlenecks to CHW service delivery common in stable low-income settings as well as the additional challenges unique to humanitarian settings. Future interventions should take into account the lessons learned from years of experience with implementation of community-based primary health care in humanitarian settings. There is also a need for rigorous assessments of community-based primary health care interventions in humanitarian settings.
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- 2020
19. Implementing integrated community case management during conflict in Yemen
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Yasmin Mohammed Alqadasi, Cashington Siameja, Sarah Ashraf, Nureyan Zunong, Taha Ali Abdulrahman Al-Sorouri, and Nathan P Miller
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Rural Population ,Yemen ,Service delivery framework ,030231 tropical medicine ,Context (language use) ,Qualitative property ,03 medical and health sciences ,0302 clinical medicine ,Health care ,Humans ,Mobile technology ,030212 general & internal medicine ,Qualitative Research ,Community Health Workers ,Primary Health Care ,business.industry ,Health Policy ,Public Health, Environmental and Occupational Health ,Public relations ,Armed Conflicts ,Community health ,Research Theme 2: Community Health in Emergencies ,Rural area ,business ,Case Management ,Delivery of Health Care ,Qualitative research - Abstract
Background The conflict in Yemen has devastated the health system, with only 51% of health facilities classified as fully functional and 19.7 million people lacking access to health care. To address the urgent need for primary health care services in rural communities, Save the Children launched an iCCM program in Lahj and Taiz Governorates. A qualitative study was conducted to document the challenges to iCCM service delivery and to aid in developing strategies for overcoming service delivery bottlenecks in conflict-affected rural areas. Methods Qualitative data were collected in Aden City, Lahj Governorate, and Taiz Governorate. Twenty-three IDIs and six FGDs were conducted with iCCM stakeholders at all levels. Results Key findings included: 1) Policy, coordination, and funding were challenged by the fact that iCCM was not integrated into the national health system and was implemented as a short-term emergency program. 2) Villages that received services from a CHW who was based in a different community experienced reduced access to services, especially during times of heightened conflict and insecurity, when CHWs could not travel. 3) Supervision, supply chain, and monitoring were all challenges that were exacerbated by difficulties in travel due to the conflict. Potential solutions to these included the use of mobile technology for supervision and data collection and pre-positioning of buffer stocks in locations closer to CHWs. 4) Travel was seen as the primary threat to the safety of CHWs and supervisors. Measures taken to reduce the risk included limiting travel during periods of heightened insecurity, safety training for CHWs, and use of mobile technology for communication. Conclusions CHWs were able to provide iCCM services in a challenging and insecure context. The challenges in delivery of services were related to both a weak health system and the conflict. Several adaptations to service delivery to overcome the bottlenecks have been identified and should be considered for future community health programs. The closure of the program in Taiz after only 14 months of implementation is a stark illustration of the failure of the current model of short-term humanitarian funding to address long-term needs in protracted emergencies.
- Published
- 2020
20. Barriers to the uptake of community-based curative child health services in Ethiopia
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Elizabeth Dankenbring, Birkety Mengistu, Mariame Sylla, Hailemariam Legesse, Meron Paulos, Nesibu Agonafir, Agazi Ameha, and Nathan P Miller
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medicine.medical_specialty ,Service delivery framework ,Child Health Services ,Qualitative property ,Community-based newborn care ,Health Services Accessibility ,Nursing ,Medicine ,Humans ,Community Health Services ,Closure (psychology) ,Child ,Service (business) ,Community Health Workers ,business.industry ,Public health ,Public Health, Environmental and Occupational Health ,Infant, Newborn ,Health extension program ,Focus Groups ,Focus group ,Integrated community case management ,Health extension workers ,Barrier analysis ,Ethiopia ,Public aspects of medicine ,RA1-1270 ,Thematic analysis ,Biostatistics ,business ,Research Article - Abstract
BackgroundUptake of services to treat newborns and children has been persistently low in Ethiopia, despite being provided free-of-charge by Health Extension Workers (HEWs). In order to increase the uptake of these services, the Optimizing the Health Extension Project was designed to be implemented in four regions in Ethiopia. This study was carried out to identify barriers to the uptake of these services and potential solutions to inform the project.MethodsQualitative data were collected in October and November 2015 in 15 purposely selected districts in four regions. We conducted 90 focus group discussions and 60 in-depth interviews reaching a total of 664 participants. Thematic analysis was used to identify key barriers and potential solutions.ResultsFive demand-side barriers to utilization of health services were identified. Misconceptions about illness causation, compounded with preference for traditional healers has affected service uptake. Limited awareness of the availability of free curative services for children at health posts; along with the prevailing perception that HEWs were providing preventive services only had constrained uptake. Geographic challenge that made access to the health post difficult was the other barrier.Four supply-side barriers were identified. Health post closure and drug stock-out led to inconsistent availability of services. Limited confidence and skill among HEWs and under-resourced physical facilities affected the service delivery.Study participants suggested demand creation solutions such as increasing community awareness on curative service availability and educating them on childhood illness causation. Maintaining consistent supplies and ensuring service availability; along with regular support to build HEWs’ confidence were the suggested supply-side solutions. Creating community feedback mechanisms was suggested as a way of addressing community concerns on the health services.ConclusionThis study explored nine demand- and supply-side barriers that decreased the uptake of community-based services. It indicated the importance of increasing awareness of new services and addressing prevailing barriers that deprioritize health services. At the same time, supply-side barriers would have to be tackled by strengthening the health system to uphold newly introduced services and harness sustainable impact.
- Published
- 2020
21. Determining the Agreement Between an Automated Respiratory Rate Counter and a Reference Standard for Detecting Symptoms of Pneumonia in Children: Protocol for a Cross-Sectional Study in Ethiopia
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Paul LaBarre, Jonathan Howard-Brand, Cindy McWhorter, Max Petzold, Charlotte Ward, Dawit Getachew, Tedila Habte, Kevin Baker, Nathan P Miller, Sarah Marks, Karin Källander, Solomie Jebessa Deribessa, and Hayalnesh Tarekegn
- Subjects
medicine.medical_specialty ,Respiratory rate ,Cross-sectional study ,Computer applications to medicine. Medical informatics ,030231 tropical medicine ,R858-859.7 ,respiratory rate ,03 medical and health sciences ,0302 clinical medicine ,030225 pediatrics ,Protocol ,diagnostics ,Medicine ,Community health workers ,pneumonia ,Reference standards ,Protocol (science) ,child ,business.industry ,Respiratory infection ,General Medicine ,medicine.disease ,Inter-rater reliability ,Pneumonia ,Emergency medicine ,Ethiopia ,business - Abstract
Background Acute respiratory infections (ARIs), primarily pneumonia, are the leading infectious cause of under-5 mortality worldwide. Manually counting respiratory rate (RR) for 60 seconds using an ARI timer is commonly practiced by community health workers to detect fast breathing, an important sign of pneumonia. However, correctly counting breaths manually and classifying the RR is challenging, often leading to inappropriate treatment. A potential solution is to introduce RR counters, which count and classify RR automatically. Objective This study aims to determine how the RR count of an Automated Respiratory Infection Diagnostic Aid (ARIDA) agrees with the count of an expert panel of pediatricians counting RR by reviewing a video of the child’s chest for 60 seconds (reference standard), for children aged younger than 5 years with cough and/or difficult breathing. Methods A cross-sectional study aiming to enroll 290 children aged 0 to 59 months presenting to pediatric in- and outpatient departments at a teaching hospital in Addis Ababa, Ethiopia, was conducted. Enrollment occurred between April and May 2017. Once enrolled, children participated in at least one of three types of RR evaluations: (1) agreement—measure the RR count of an ARIDA in comparison with the reference standard, (2) consistency—measure the agreement between two ARIDA devices strapped to one child, and (3) RR fluctuation—measure RR count variability over time after ARIDA attachment as measured by a manual count. The agreement and consistency of expert clinicians (ECs) counting RR for the same child with the Mark 2 ARI timer for 60 seconds was also measured in comparison with the reference standard. Results Primary outcomes were (1) mean difference between the ARIDA and reference standard RR count (agreement) and (2) mean difference between RR counts obtained by two ARIDA devices started simultaneously (consistency). Conclusions Study strengths included the design allowing for comparison between both ARIDA and the EC with the reference standard RR count. A limitation is that exactly the same set of breaths were not compared between ARIDA and the reference standard since ARIDA can take longer than 60 seconds to count RR. Also, manual RR counting, even when aided by a video of the child’s chest movements, is subject to human error and can result in low interrater reliability. Further work is needed to reach global consensus on the most appropriate reference standard and an acceptable level of agreement to provide ministries of health with evidence to make an informed decision on whether to scale up new automated RR counters. Trial Registration ClinicalTrials.gov NCT03067558; https://clinicaltrials.gov/ct2/show/NCT03067558 International Registered Report Identifier (IRRID) RR1-10.2196/16531
- Published
- 2020
22. Assessing community health worker service delivery in humanitarian settings
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Nathan P Miller, Melissa A. Marx, Naoko Kozuki, Adam K. Richards, and Francesco Checchi
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Community Health Workers ,Data collection ,Service delivery framework ,business.industry ,Data Collection ,Health Policy ,media_common.quotation_subject ,Public Health, Environmental and Occupational Health ,MEDLINE ,Public relations ,Altruism ,Health Services Accessibility ,Viewpoints ,Political science ,Community health ,Humans ,Community health workers ,Community Health Services ,business ,Delivery of Health Care ,Cell Phone ,Qualitative Research ,Qualitative research ,media_common - Published
- 2020
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23. Approaches to support continued iCCM implementation during a flooding emergency in rural Bangladesh
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Rashed Shah, Nathan P Miller, and Golam Mothabbir
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Service delivery framework ,030231 tropical medicine ,Qualitative property ,Disasters ,03 medical and health sciences ,0302 clinical medicine ,Community health care ,medicine ,Humans ,030212 general & internal medicine ,Natural disaster ,Qualitative Research ,Retrospective Studies ,Bangladesh ,Delivery of Health Care, Integrated ,Health Policy ,Public Health, Environmental and Occupational Health ,Focus Groups ,medicine.disease ,Focus group ,Floods ,Flooding (computer networking) ,Research Theme 6: Community Health in Emergencies ,Preparedness ,Medical emergency ,Business ,Rural Health Services ,Case Management ,Qualitative research - Abstract
Background More evidence is needed on how integrated community case management (iCCM) service delivery is affected and on how to maintain service availability during crises. This study documented the implementation of iCCM through two cadres of community health workers (community health care providers [CHCPs] and village doctors [VDs]) in communities that were affected by a 2015 flooding emergency in Bangladesh. Methods We conducted a retrospective case study to assess iCCM services provided by CHCPs and VDs during a flooding emergency that occurred from June to August 2015. We purposively selected nine unions within four sub-districts in Bhola District. In this mixed methods study, we analyzed trends in quantitative service delivery indicators over the time period from January 2015 to February 2016. Qualitative data were obtained through 28 in-depth interviews and 13 focus group discussions with policy makers, implementers, supervisors, CHCPs, VDs, community leaders, and caregivers of under-five children. Results All stakeholders reported disruptions in iCCM service delivery and in access to CHCPs and VDs for community members. The quantitative data showed a 30% reduction in average number of children who received treatment from both CHCPs and VDs during flooding months compared to pre-flood months (from 2273/month to 1593/month). There was also an increase in the number of children referred by CHCPs and VDs, reduced supervision, and increased stock-outs of commodities during the flooding months. CHCPs and VDs, in collaboration with community members, came up with several locally adapted initiatives to maintain iCCM services, including changing clinic hours according to the tide, organizing temporary clinics at alternative sites that were located on higher ground, use of community boats to visit clients in their homes, and use of mobile phones for communication with supervisors and community members. Conclusion Our study results demonstrate that iCCM services can continue during a natural disaster, albeit with significant disruptions. Ad hoc adaptations to services by local implementers and community members were key in maintaining availability of services during the emergency. In future emergencies, service delivery could be significantly strengthened by enacting key preparedness activities prior to a natural disaster such as severe flooding.
- Published
- 2020
24. Toward transparent governance of transboundary fisheries: The case of Pacific tuna transshipment
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Mark Young, Nathan P Miller, Katherine Seto, and Quentin A Hanich
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0106 biological sciences ,Economics and Econometrics ,Traceability ,Commodity chain ,010604 marine biology & hydrobiology ,Corporate governance ,04 agricultural and veterinary sciences ,Management, Monitoring, Policy and Law ,Aquatic Science ,Fish stock ,01 natural sciences ,Transparency (behavior) ,Pacific ocean ,Fishery ,Environmental governance ,040102 fisheries ,0401 agriculture, forestry, and fisheries ,Business ,Tuna ,Law ,General Environmental Science - Abstract
Transparency is one of the most influential themes in global environmental governance, however it has received limited treatment in transboundary fisheries. Transparency is essential to ensure officials are held accountable for the use of public resources and the achievement of environmental objectives, such as sustainable harvest. Here, we use a case study approach to assess transparency in transboundary fisheries governance, evaluating transshipment in the Western and Central Pacific Ocean, one of the world's most abundant and lucrative fisheries. Transshipment at sea occurs extensively in these fisheries, but often lacks strong monitoring and oversight, and has been associated with illegal or illicit activities. However, actors that rely heavily on transshipment at sea maintain that it can be a legitimate part of the fish commodity chain, under effective regulation. Here we assess whether at-sea transshipment in one of the most regulated and visible fisheries in the world is traceable, verifiable, and legal. Using AIS data and qualitative information from regional and sub-regional sources, we find that 68% of observed potential transshipments remain unsubstantiated even after triangulating with diverse data. We identify three primary areas for improving traceability and transparency of transshipment at sea in the WCPO, and suggest that transparency is ultimately hindered less by technical or administrative constraints, but by tensions between the actors and objectives within management institutions. Increased transparency, and a focus on the underlying dynamics that inhibit it, is necessary to ensure effective conservation and management of transboundary fish stocks, now and in the future.
- Published
- 2022
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25. Determining the Agreement Between an Automated Respiratory Rate Counter and a Reference Standard for Detecting Symptoms of Pneumonia in Children: Protocol for a Cross-Sectional Study in Ethiopia (Preprint)
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Charlotte Ward, Kevin Baker, Sarah Marks, Dawit Getachew, Tedila Habte, Cindy McWhorter, Paul Labarre, Jonathan Howard-Brand, Nathan P Miller, Hayalnesh Tarekegn, Solomie Jebessa Deribessa, Max Petzold, and Karin Kallander
- Abstract
BACKGROUND Acute respiratory infections (ARIs), primarily pneumonia, are the leading infectious cause of under-5 mortality worldwide. Manually counting respiratory rate (RR) for 60 seconds using an ARI timer is commonly practiced by community health workers to detect fast breathing, an important sign of pneumonia. However, correctly counting breaths manually and classifying the RR is challenging, often leading to inappropriate treatment. A potential solution is to introduce RR counters, which count and classify RR automatically. OBJECTIVE This study aims to determine how the RR count of an Automated Respiratory Infection Diagnostic Aid (ARIDA) agrees with the count of an expert panel of pediatricians counting RR by reviewing a video of the child’s chest for 60 seconds (reference standard), for children aged younger than 5 years with cough and/or difficult breathing. METHODS A cross-sectional study aiming to enroll 290 children aged 0 to 59 months presenting to pediatric in- and outpatient departments at a teaching hospital in Addis Ababa, Ethiopia, was conducted. Enrollment occurred between April and May 2017. Once enrolled, children participated in at least one of three types of RR evaluations: (1) agreement—measure the RR count of an ARIDA in comparison with the reference standard, (2) consistency—measure the agreement between two ARIDA devices strapped to one child, and (3) RR fluctuation—measure RR count variability over time after ARIDA attachment as measured by a manual count. The agreement and consistency of expert clinicians (ECs) counting RR for the same child with the Mark 2 ARI timer for 60 seconds was also measured in comparison with the reference standard. RESULTS Primary outcomes were (1) mean difference between the ARIDA and reference standard RR count (agreement) and (2) mean difference between RR counts obtained by two ARIDA devices started simultaneously (consistency). CONCLUSIONS Study strengths included the design allowing for comparison between both ARIDA and the EC with the reference standard RR count. A limitation is that exactly the same set of breaths were not compared between ARIDA and the reference standard since ARIDA can take longer than 60 seconds to count RR. Also, manual RR counting, even when aided by a video of the child’s chest movements, is subject to human error and can result in low interrater reliability. Further work is needed to reach global consensus on the most appropriate reference standard and an acceptable level of agreement to provide ministries of health with evidence to make an informed decision on whether to scale up new automated RR counters. CLINICALTRIAL ClinicalTrials.gov NCT03067558; https://clinicaltrials.gov/ct2/show/NCT03067558 INTERNATIONAL REGISTERED REPORT RR1-10.2196/16531
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- 2019
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26. Effects of the integrated Community Case Management of Childhood Illness Strategy on Child Mortality in Ethiopia: A Cluster Randomized Trial
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Mengistu Tafesse, Yared Mekonnen, Robert E. Black, Agbessi Amouzou, Jennifer Bryce, Nathan P Miller, Bryan Shaw, Lawrence H. Moulton, and Elizabeth Hazel
- Subjects
Adult ,Diarrhea ,Program evaluation ,Pediatrics ,medicine.medical_specialty ,030231 tropical medicine ,Population ,Developing country ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,law ,Virology ,Environmental health ,medicine ,Humans ,Community Health Services ,030212 general & internal medicine ,Cluster randomised controlled trial ,education ,education.field_of_study ,Delivery of Health Care, Integrated ,business.industry ,Infant ,Pneumonia ,Articles ,medicine.disease ,Malaria ,Clinical trial ,Child mortality ,Infectious Diseases ,Child, Preschool ,Child Mortality ,Communicable Disease Control ,Female ,Parasitology ,Ethiopia ,business - Abstract
We conducted a cluster randomized trial of the effects of the integrated community case management of childhood illness (iCCM) strategy on careseeking for and coverage of correct treatment of suspected pneumonia, diarrhea, and malaria, and mortality among children aged 2–59 months in 31 districts of the Oromia region of Ethiopia. We conducted baseline and endline coverage and mortality surveys approximately 2 years apart, and assessed program strength after about 1 year of implementation. Results showed strong iCCM implementation, with iCCM-trained workers providing generally good quality of care. However, few sick children were taken to iCCM providers (average 16 per month). Difference in differences analyses revealed that careseeking for childhood illness was low and similar in both study arms at baseline and endline, and increased only marginally in intervention (22.9–25.7%) and comparison (23.3–29.3%) areas over the study period (P = 0.77). Mortality declined at similar rates in both study arms. Ethiopia's iCCM program did not generate levels of demand and utilization sufficient to achieve significant increases in intervention coverage and a resulting acceleration in reductions in child mortality. This evaluation has allowed Ethiopia to strengthen its strategic approaches to increasing population demand and use of iCCM services.
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- 2016
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27. The resilience of integrated community case management in acute emergency: a case study from Unity State, South Sudan
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Naoko Kozuki, Katja Ericson, Yolanda Barberá Laínez, Nathan P Miller, and Bethany Marron
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Program evaluation ,030231 tropical medicine ,Population ,Child Health Services ,03 medical and health sciences ,0302 clinical medicine ,Nursing ,Political science ,Humans ,030212 general & internal medicine ,education ,South Sudan ,Qualitative Research ,Community Health Workers ,education.field_of_study ,Delivery of Health Care, Integrated ,Health Policy ,Public Health, Environmental and Occupational Health ,Infant ,Armed Conflicts ,Focus Groups ,Focus group ,Health indicator ,Resilience (organizational) ,Community mobilization ,Internally displaced person ,Child, Preschool ,Case Management ,Qualitative research ,Program Evaluation - Abstract
Background An active conflict in South Sudan in late 2013/early 2014 displaced approximately 2 million people over the course of several months. In May 2015, the International Rescue Committee and UNICEF conducted a mixed-methods case study of the impact of that acute emergency on integrated community case management (iCCM) of childhood illness programming in Payinjiar County, Unity State. The objective was to document the operations of an iCCM program during an acute crisis and to assess the program's ability to continue operations. Results This mixed-methods case study is comprised of semi-structured interviews and focus groups with key stakeholders such as policymakers, program implementers, community health workers (CHWs), and caregivers on their experience with iCCM programming during this time period. Routine program data were also analyzed to assess the effect of the crisis on key health indicators. Findings Internally displaced persons (IDPs) nearly doubled the population in Payinjiar. Some displaced CHWs continued to provide treatment in host communities when they were able to take supplies with them. Despite no formal community mobilization effort by the iCCM program, many IDPs identified CHWs in the communities they were displaced to and obtained care from them. Caregivers who had been internally displaced reported preferring care from CHWs especially in contrast to risking an insecure journey to health facilities. The total number of treatments provided per month by CHWs dropped during the acute crisis, but recovered to pre-crisis levels within six months. CHW supervisors attempted to continue supervision by utilizing their networks to track down displaced CHWs and assess the security situation prior to visits. The monthly supervision rate dropped to the lowest level of 77% in February 2014, but rebounded to 91% by August 2014. Several CHWs and community leaders qualitatively validated this claim of sustained supervision. Conclusions CHWs, including those who were internally displaced, continued to provide treatment for childhood illnesses during an acute emergency, and service provision recovered faster to pre-crisis levels than the formal health sector. International donors and humanitarian actors should recognize iCCM as a potentially high-impact humanitarian response. Flexible funding from donors would enable further evidence generation on iCCM approaches and improvements that could both sustain and enhance programming in acute crisis.
- Published
- 2018
28. The Cosmology Large Angular Scale Surveyor Receiver Design
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Joseph Cleary, Johannes Hubmayr, Ricardo Bustos, Gonzalo A. Palma, Kevin L. Denis, Nathan P Miller, Matthew Petroff, Jullianna Couto, Thomas Essinger-Hileman, Charles L. Bennett, Janet Weiland, Sumit Dahal, Michael K. Brewer, Tobias A. Marriage, Duncan J. Watts, Qinan Wang, Jeffrey Iuliano, Ivan L. Padilla, Lucas Parker, Karwan Rostem, Kyle Helson, Deniz Augusto Nunes Valle, David T. Chuss, Edward J. Wollack, Lingzhen Zeng, Carolina Núñez, Pedro Fluxa, John W. Appel, John Karakla, Rolando Dünner, Gene C. Hilton, Aamir Ali, Joseph Eimer, Carl D. Reintsema, Jeff McMahon, Rodrigo Reeves, Ziang Yan, Trevor Van Engelhoven, Zhilei Xu, Bingjie Wang, Bastian Pradenas Marquez, Gary Rhoades, Mark Halpern, Kathleen Harrington, and Gary Hinshaw
- Subjects
Physics ,Optical efficiency ,Cosmology Large Angular Scale Surveyor ,Stray light ,business.industry ,Cosmic microwave background ,Detector ,Astrophysics::Instrumentation and Methods for Astrophysics ,FOS: Physical sciences ,Cryogenics ,Astrophysics::Cosmology and Extragalactic Astrophysics ,Polarization (waves) ,01 natural sciences ,7. Clean energy ,010309 optics ,Optics ,0103 physical sciences ,Electromagnetic shielding ,business ,Astrophysics - Instrumentation and Methods for Astrophysics ,Instrumentation and Methods for Astrophysics (astro-ph.IM) ,010303 astronomy & astrophysics - Abstract
The Cosmology Large Angular Scale Surveyor consists of four instruments performing a CMB polarization survey. Currently, the 40 GHz and first 90 GHz instruments are deployed and observing, with the second 90 GHz and a multichroic 150/220 GHz instrument to follow. The receiver is a central component of each instrument's design and functionality. This paper describes the CLASS receiver design, using the first 90 GHz receiver as a primary reference. Cryogenic cooling and filters maintain a cold, low-noise environment for the detectors. We have achieved receiver detector temperatures below 50 mK in the 40 GHz instrument for 85% of the initial 1.5 years of operation, and observed in-band efficiency that is consistent with pre-deployment estimates. At 90 GHz, less than 26% of in-band power is lost to the filters and lenses in the receiver, allowing for high optical efficiency. We discuss the mounting scheme for the filters and lenses, the alignment of the cold optics and detectors, stray light control, and magnetic shielding., Fixed formatting of abstract; 20 Pages, 11 Figures, SPIE Conference Proceedings
- Published
- 2018
29. Design and characterization of the Cosmology Large Angular Scale Surveyor (CLASS) 93 GHz focal plane
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Johannes Hubmayr, Mark Halpern, Joseph Cleary, Kyle Helson, Thomas Essinger-Hileman, Aamir Ali, Janet Weiland, Lucas Parker, Nathan P Miller, Sumit Dahal, Carolina Núñez, Pedro Fluxa, John Karakla, Rolando Dünner, Qinan Wang, Kevin L. Denis, Joseph Eimer, Kathleen Harrington, Lingzhen Zeng, Duncan J. Watts, Felipe Colazo, Jeffery Iuliano, Manwei Chan, Deniz Augusto Nunes Valle, Kongpop U-Yen, Carl D. Reintsema, Jeff McMahon, Karwan Rostem, Gary Hinshaw, Edward J. Wollack, Tobias A. Marriage, Matthew Petroff, Charles L. Bennett, David T. Chuss, Bingjie Wang, J. W. Appel, Trevor Van Engelhoven, Ziang Yan, Michael K. Brewer, Bastián Pradenas, Ricardo Bustos, Rodrigo Reeves, Gene C. Hilton, Jullianna Couto, I. L. Padilla, Zhilei Xu, Marco Sagliocca, and Gonzalo A. Palma
- Subjects
Physics ,Cosmology and Nongalactic Astrophysics (astro-ph.CO) ,business.industry ,Cosmology Large Angular Scale Surveyor ,Physics::Instrumentation and Detectors ,Detector ,Astrophysics::Instrumentation and Methods for Astrophysics ,FOS: Physical sciences ,Polarimeter ,Astrophysics::Cosmology and Extragalactic Astrophysics ,01 natural sciences ,Noise (electronics) ,Orthomode transducer ,Optics ,Cardinal point ,0103 physical sciences ,010306 general physics ,business ,Astrophysics - Instrumentation and Methods for Astrophysics ,010303 astronomy & astrophysics ,Reionization ,Instrumentation and Methods for Astrophysics (astro-ph.IM) ,Microwave ,Astrophysics - Cosmology and Nongalactic Astrophysics - Abstract
The Cosmology Large Angular Scale Surveyor (CLASS) aims to detect and characterize the primordial B-mode signal and make a sample-variance-limited measurement of the optical depth to reionization. CLASS is a ground-based, multi-frequency microwave polarimeter that surveys 70% of the microwave sky every day from the Atacama Desert. The focal plane detector arrays of all CLASS telescopes contain smooth-walled feedhorns that couple to transition-edge sensor (TES) bolometers through symmetric planar orthomode transducer (OMT) antennas. These low noise polarization-sensitive detector arrays are fabricated on mono-crystalline silicon wafers to maintain TES uniformity and optimize optical efficiency throughout the wafer. In this paper, we discuss the design and characterization of the first CLASS 93 GHz detector array. We measure the dark parameters, bandpass, and noise spectra of the detectors and report that the detectors are photon-noise limited. With current array yield of 82%, we estimate the total array noise-equivalent power (NEP) to be 2.1 aW$\sqrt[]{\mathrm{s}}$., Comment: 16 pages, 9 figures
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- 2018
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30. Determinants of Utilization of Health Extension Workers in the Context of Scale-Up of Integrated Community Case Management of Childhood Illnesses in Ethiopia
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Nathan P Miller, Agbessi Amouzou, Amy O. Tsui, Jennifer Bryce, Mengistu Tafesse, Bryan Shaw, and Pamela J. Surkan
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Adult ,Diarrhea ,medicine.medical_specialty ,Adolescent ,Fever ,Cross-sectional study ,Child sick ,Child Health Services ,Population ,Developing country ,Context (language use) ,Young Adult ,Virology ,Humans ,Medicine ,Illness severity ,Community Health Services ,Child ,education ,education.field_of_study ,business.industry ,Rural health ,Articles ,Pneumonia ,Middle Aged ,Patient Acceptance of Health Care ,Case management ,Cross-Sectional Studies ,Infectious Diseases ,Caregivers ,Family medicine ,Workforce ,Female ,Parasitology ,Ethiopia ,business ,Delivery of Health Care - Abstract
Ethiopia has invested significant resources in integrated community case management (iCCM) of childhood illness. In Oromia Region, iCCM scale-up was phased in, allowing for comparisons between districts providing iCCM and routine services. We assessed the determinants of utilization of health extension workers (HEWs) delivering iCCM services at rural health posts by caregivers of sick, under-five children in a cross-sectional survey. We found low utilization of HEWs with only 9.3% of caregivers of a child sick with diarrhea, fever, and/or pneumonia in the previous 2 weeks taking their child to HEWs in both iCCM and routine areas. There was a higher likelihood of utilization of HEWs in iCCM areas (OR: 1.44; 95% CI: 0.97-2.12; P = 0.07), but this effect disappeared after accounting for confounders. In iCCM areas, maternal education, illness type, and distance were associated with utilization. Perceptions of illness severity and service quality were the primary reasons given for not utilizing the health post. Our findings suggest that though iCCM is reaching some vulnerable populations, there remain significant barriers to use of HEWs delivering iCCM services. Efforts for demand generation and minimization of remaining barriers are urgently needed for the sustained success of the iCCM strategy in Ethiopia.
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- 2015
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31. Assessment of the impact of quality improvement interventions on the quality of sick child care provided by Health Extension Workers in Ethiopia
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Elizabeth Hazel, Nathan P Miller, Tedbabe Degefie, Robert E. Black, Hailemariam Legesse, Jennifer Bryce, Mengistu Tafesse, and Agbessi Amouzou
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Program evaluation ,medicine.medical_specialty ,Multivariate analysis ,Quality management ,030231 tropical medicine ,Child Health Services ,Psychological intervention ,MEDLINE ,Logistic regression ,Odds ,03 medical and health sciences ,0302 clinical medicine ,medicine ,Odds Ratio ,Humans ,030212 general & internal medicine ,Quality of Health Care ,Community Health Workers ,business.industry ,Health Policy ,Public Health, Environmental and Occupational Health ,Child Health ,Infant ,Mentoring ,Odds ratio ,Articles ,Quality Improvement ,Logistic Models ,Family medicine ,Child, Preschool ,Clinical Competence ,Ethiopia ,business ,Case Management ,Delivery of Health Care - Abstract
Background Ethiopia has scaled up integrated community case management of childhood illness (iCCM), including several interventions to improve the performance of Health Extension Workers (HEWs). We assessed associations between interventions to improve iCCM quality of care and the observed quality of care among HEWs. Methods We assessed iCCM implementation strength and quality of care provided by HEWs in Ethiopia. Multivariate logistic regression analyses were performed to assess associations between interventions to improve iCCM quality of care and correct management of iCCM illnesses. Findings Children who were managed by an HEW who had attended a performance review and clinical mentoring meeting (PRCMM) had 8.3 (95% confidence interval (CI) 2.34–29.51) times the odds of being correctly managed, compared to children managed by an HEW who did not attend a PRCMM. Management by an HEW who received follow–up training also significantly increased the odds of correct management (odds ratio (OR) = 2.09, 95% CI 1.05–4.18). Supervision on iCCM (OR = 0.63, 95% CI 0.23–1.72) did not significantly affect the odds of receiving correct care. Conclusions These results suggest PRCMM and follow–up training were effective interventions, while implementation of supportive supervision needs to be reviewed to improve impact.
- Published
- 2016
32. Community health systems: allowing community health workers to emerge from the shadows
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Nathan P Miller, Mark Young, Stefan Peterson, Maureen Momanyi, David B Hipgrave, Dolores Rio, Luwei Pearson, Sagri Singh, Jérôme Pfaffmann Zambruni, Magali Romedenne, and Kumanan Rasanathan
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Community Health Workers ,medicine.medical_specialty ,lcsh:Public aspects of medicine ,030503 health policy & services ,MEDLINE ,lcsh:RA1-1270 ,General Medicine ,Community health planning ,Community Health Planning ,03 medical and health sciences ,0302 clinical medicine ,Political science ,Family medicine ,Community health ,medicine ,Humans ,Community health workers ,Community Health Services ,030212 general & internal medicine ,0305 other medical science - Published
- 2017
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33. Coverage and equitability of interventions to prevent child mortality in rural Jimma and West Hararghe Zones, Oromia Region, Ethiopia
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Nathan P, Miller, Tedbabe, Degefie, Elizabeth, Hazel, Hailemariam, Legesse, Taye, Tolera, and Agbessi, Amouzou
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Male ,Rural Population ,Child Health Services ,Infant ,Health Services Accessibility ,Cross-Sectional Studies ,Child, Preschool ,Child Mortality ,Preventive Health Services ,Humans ,Female ,Community Health Services ,Ethiopia ,Healthcare Disparities ,Child - Abstract
Interventions to prevent childhood illnesses are important components of the Ethiopian Health Extension Program (HEP). Although the HEP was designed to reduce inequities in access to health care, there is little evidence on equitability of preventive interventions in Ethiopia.This article describes coverage of preventive interventions and how many interventions individual children received We also examined which factors were associated with the number of preventive interventions received, and assessed the extent to which interventions were equitably distributed.We conducted a cross-sectional survey in 3,200 randomly selected households in the rural Jimma and West Hararghe Zones of Ethiopia's Oromia Region. We calculated coverage of 10 preventive interventions and a composite of eight interventions (co-coverage) representing the number of interventions received by children. Mul- tiple linear regressions were used to assess associations between co-coverage and explanatory variables. Finally, we assessed the equitability of preventive interventions by comparing coverage among children in the poorest and the least poor wealth quintiles.Coverage was less than 50% for six of the 10 interventions. Children received on average only three of the eight interventions included in the co-coverage calculation. Zone, gender, caretaker age, religion, and household wealth were all significantly associated with co-coverage, controlling for key covariates. Exclusive breastfeeding, vaccine uptake, and vitamin A supplementation were all relatively equitable. On the other hand, coverage of insecticide-treated nets or indoor residual spraying (ITN/IRS) and access to safe water were significantly higher among the least poor children compared to children in the poorest quintile.Coverage of key interventions to prevent childhood illnesses is generally low in Jimma and West Hararghe. Although a number of interventions were equitably distributed, there were marked wealth-based inequities for interventions that are possessed at the household level, even among relatively homogeneous rural communities.
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- 2015
34. Assessing the Quality of Sick Child Care Provided by Community Health Workers
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Elizabeth Hazel, Luwei Pearson, Agbessi Amouzou, Robert E. Black, Jennifer Bryce, Nathan P Miller, Hailemariam Legesse, Mengistu Tafesse, and Tedbabe Degefie
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Male ,media_common.quotation_subject ,MEDLINE ,lcsh:Medicine ,Nursing ,Environmental health ,Humans ,Medicine ,Community health workers ,Quality (business) ,lcsh:Science ,Quality of Health Care ,media_common ,Community Health Workers ,Multidisciplinary ,Receiver operating characteristic ,business.industry ,Hawthorne effect ,Gold standard ,lcsh:R ,Child Health ,Infant ,Community Health Centers ,medicine.disease ,Malnutrition ,ROC Curve ,Area Under Curve ,Child, Preschool ,Community health ,Female ,lcsh:Q ,Ethiopia ,business ,Research Article - Abstract
Background As community case management of childhood illness expands in low-income countries, there is a need to assess the quality of care provided by community health workers. This study had the following objectives: 1) examine methods of recruitment of sick children for assessment of quality of care, 2) assess the validity of register review (RR) and direct observation only (DO) compared to direct observation with re-examination (DO+RE), and 3) assess the effect of observation on community health worker performance. Methods We conducted a survey to assess the quality of care provided by Ethiopian Health Extension Workers (HEWs). The sample of children was obtained through spontaneous consultation, HEW mobilization, or recruitment by the survey team. We assessed patient characteristics by recruitment method. Estimates of indicators of quality of care obtained using RR and DO were compared to gold standard estimates obtained through DO+RE. Sensitivity, specificity, and the area under receiver operator characteristic curve (AUC) were calculated to assess the validity of RR and DO. To assess the Hawthorne effect, we compared estimates from RR for children who were observed by the survey team to estimates from RR for children who were not observed by the survey team. Results Participants included 137 HEWs and 257 sick children in 103 health posts, plus 544 children from patient registers. Children mobilized by HEWs had the highest proportion of severe illness (27%). Indicators of quality of care from RR and DO had high sensitivity for most indicators, but specificity was low. The AUC for different indicators from RR ranged from 0.47 to 0.76, with only one indicator above 0.75. The AUC of indicators from DO ranged from 0.54 to 1.0, with three indicators above 0.75. The differences between estimates of correct care for observed versus not observed children were small. Conclusions Mobilization by HEWs and recruitment by the survey teams were feasible, but potentially biased, methods of obtaining sick children. Register review and DO underestimated performance errors. Our data suggest that being observed had only a small positive effect on the performance of HEWs.
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- 2015
35. CLASS: the cosmology large angular scale surveyor
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Nathan P Miller, Manwei Chan, David Larson, Duncan J. Watts, John W. Appel, Fletcher Boone, Lingzhen Zeng, Alan J. Kogut, Karwan Rostem, David T. Chuss, Felipe Colazo, Kathleen Harrington, Amber Miller, Michele Limon, Emily Wagner, Thomas Essinger-Hileman, Tobias A. Marriage, Gene C. Hilton, Deborah Towner, Erik Crowe, Kent D. Irwin, L. N. Lowry, Kongpop U-Yen, Hsiao-Mei Cho, Edward J. Wollack, Caroline Huang, Glenn Jones, Aamir Ali, John Karakla, Rolando Dünner, Dominik Gothe, Joseph Eimer, Mark Halpern, Derek Araujo, Gary Hinshaw, Carl D. Reintsema, Giles Novak, Zhilei Xu, Thomas R. Stevenson, Mandana Amiri, Kevin L. Denis, Charles L. Bennett, Nicholas Mehrle, and Samuel H. Moseley
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Physics ,Cosmology Large Angular Scale Surveyor ,Scattering ,media_common.quotation_subject ,Cosmic microwave background ,Astrophysics::Instrumentation and Methods for Astrophysics ,FOS: Physical sciences ,Spectral density ,Astrophysics::Cosmology and Extragalactic Astrophysics ,Astrophysics ,Polarization (waves) ,7. Clean energy ,13. Climate action ,Sky ,Astrophysics - Instrumentation and Methods for Astrophysics ,Instrumentation and Methods for Astrophysics (astro-ph.IM) ,Reionization ,Four-frequency ,Astrophysics::Galaxy Astrophysics ,media_common - Abstract
The Cosmology Large Angular Scale Surveyor (CLASS) is an experiment to measure the signature of a gravita-tional-wave background from inflation in the polarization of the cosmic microwave background (CMB). CLASS is a multi-frequency array of four telescopes operating from a high-altitude site in the Atacama Desert in Chile. CLASS will survey 70\% of the sky in four frequency bands centered at 38, 93, 148, and 217 GHz, which are chosen to straddle the Galactic-foreground minimum while avoiding strong atmospheric emission lines. This broad frequency coverage ensures that CLASS can distinguish Galactic emission from the CMB. The sky fraction of the CLASS survey will allow the full shape of the primordial B-mode power spectrum to be characterized, including the signal from reionization at low $\ell$. Its unique combination of large sky coverage, control of systematic errors, and high sensitivity will allow CLASS to measure or place upper limits on the tensor-to-scalar ratio at a level of $r=0.01$ and make a cosmic-variance-limited measurement of the optical depth to the surface of last scattering, $\tau$., Comment: 23 pages, 10 figures, Presented at SPIE Astronomical Telescopes and Instrumentation 2014: Millimeter, Submillimeter, and Far-Infrared Detectors and Instrumentation for Astronomy VII. To be published in Proceedings of SPIE Volume 9153
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- 2014
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36. Integrated community case management of childhood illness in Ethiopia: implementation strength and quality of care
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Tedbabe Degefie, Agbessi Amouzou, Nathan P Miller, Jennifer Bryce, Robert E. Black, Hailemariam Legesse, Cesar G. Victora, Mengistu Tafesse, and Elizabeth Hazel
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Program evaluation ,Diarrhea ,Male ,medicine.medical_specialty ,Population ,Developing country ,Nursing ,Virology ,medicine ,Pneumonia, Bacterial ,Humans ,Otitis ,Quality of care ,education ,Child ,Developing Countries ,Quality of Health Care ,Community Health Workers ,education.field_of_study ,business.industry ,Gold standard ,Malnutrition ,Infant ,Articles ,medicine.disease ,Malaria ,Child mortality ,Infectious Diseases ,Family medicine ,Scale (social sciences) ,Child, Preschool ,Parasitology ,Female ,Ethiopia ,business ,Case Management ,Measles - Abstract
Ethiopia has scaled up integrated community case management of childhood illness (iCCM) in most regions. We assessed the strength of iCCM implementation and the quality of care provided by health extension workers (HEWs). Data collectors observed HEWs' consultations with sick children and carried out gold standard re-examinations. Nearly all HEWs received training and supervision, and essential commodities were available. HEWs provided correct case management for 64% of children. The proportions of children correctly managed for pneumonia, diarrhea, and malnutrition were 72%, 79%, and 59%, respectively. Only 34% of children with severe illness were correctly managed. Health posts saw an average of 16 sick children in the previous 1 month. These results show that iCCM can be implemented at scale and that community-based HEWs can correctly manage multiple illnesses. However, to increase the chances of impact on child mortality, management of severe illness and use of iCCM services must be improved.
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- 2014
37. The Cosmology Large Angular Scale Surveyor (CLASS): 38 GHz detector array of bolometric polarimeters
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Rolando Dünner, Carl Reintsemad, Joseph Eimer, Tobias A. Marriage, Glenn Jones, Nathan P Miller, Aamir Ali, Gene C. Hilton, John W. Appel, L. N. Lowry, Erik Crowe, Zhilei Xu, Duncan J. Watts, Lingzhen Zeng, David L. Larson, Nicholas Mehrle, Deborah Towner, Derek Araujo, Gary Hinshaw, Amber Miller, Alan J. Kogut, Kathleen Harrington, Thomas Stevensonb, Kevin L. Denis, Dominik Gothe, Felipe Colazo, Charles L. Bennett, Kent D. Irwin, Mandana Amiri, Hsiao-Mei Cho, Edward J. Wollack, Caroline Huang, Thomas Essinger-Hileman, Samuel H. Moseleyb, Mark Halpern, Manwei Chan, Michele Limon, Kongpop U-Yen, Karwan Rostemab, John Karakla, Giles Novakh, Fletcher Boone, David T. Chuss, and Emily Wagner
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Physics ,Cosmology Large Angular Scale Surveyor ,media_common.quotation_subject ,Bolometer ,Cosmic microwave background ,Detector ,Astrophysics::Instrumentation and Methods for Astrophysics ,Astronomy ,FOS: Physical sciences ,Polarimeter ,Astrophysics::Cosmology and Extragalactic Astrophysics ,Polarization (waves) ,7. Clean energy ,law.invention ,Cardinal point ,law ,Sky ,Astrophysics::Earth and Planetary Astrophysics ,Astrophysics - Instrumentation and Methods for Astrophysics ,Instrumentation and Methods for Astrophysics (astro-ph.IM) ,Astrophysics::Galaxy Astrophysics ,media_common - Abstract
The Cosmology Large Angular Scale Surveyor (CLASS) experiment aims to map the polarization of the Cosmic Microwave Background (CMB) at angular scales larger than a few degrees. Operating from Cerro Toco in the Atacama Desert of Chile, it will observe over 65% of the sky at 38, 93, 148, and 217 GHz. In this paper we discuss the design, construction, and characterization of the CLASS 38 GHz detector focal plane, the first ever Q-band bolometric polarimeter array., Comment: 15 pages, 4 figures. Presented at SPIE Astronomical Telescopes and Instrumentation 2014: Millimeter, Submillimeter, and Far-Infrared Detectors and Instrumentation for Astronomy VII. To be published in Proceedings of SPIE Volume 9153
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- 2014
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38. Quality of malaria case management at outpatient health facilities in Angola
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Ana Carolina Faria e Silva Santelli, Pedro Van-Dúnem, Gabriel Ponce de Leon, Jules Mihigo, Alexander K. Rowe, and Nathan P Miller
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Male ,Pediatrics ,Cross-sectional study ,Ambulatory Care Facilities ,Outpatients ,Medicine ,Artemether ,Malaria, Falciparum ,Child ,Aged, 80 and over ,Health Policy ,Middle Aged ,Artemisinins ,Drug Combinations ,Infectious Diseases ,Ethanolamines ,Child, Preschool ,Female ,Guideline Adherence ,medicine.drug ,Adult ,medicine.medical_specialty ,lcsh:Arctic medicine. Tropical medicine ,Adolescent ,lcsh:RC955-962 ,Health Personnel ,Plasmodium falciparum ,lcsh:Infectious and parasitic diseases ,Antimalarials ,Young Adult ,parasitic diseases ,Humans ,lcsh:RC109-216 ,Health policy ,Aged ,Quality of Health Care ,Fluorenes ,business.industry ,Public health ,Research ,Artemether, Lumefantrine Drug Combination ,Infant, Newborn ,Clinical supervision ,Infant ,Odds ratio ,medicine.disease ,Cross-Sectional Studies ,Angola ,Family medicine ,Tropical medicine ,Parasitology ,business ,Case Management ,Malaria - Abstract
Background Angola's malaria case-management policy recommends treatment with artemether-lumefantrine (AL). In 2006, AL implementation began in Huambo Province, which involved training health workers (HWs), supervision, delivering AL to health facilities, and improving malaria testing with microscopy and rapid diagnostic tests (RDTs). Implementation was complicated by a policy that was sometimes ambiguous. Methods Fourteen months after implementation began, a cross-sectional survey was conducted in 33 outpatient facilities in Huambo Province to assess their readiness to manage malaria and the quality of malaria case-management for patients of all ages. Consultations were observed, patients were interviewed and re-examined, and HWs were interviewed. Results Ninety-three HWs and 177 consultations were evaluated, although many sampled consultations were missed. All facilities had AL in-stock and at least one HW trained to use AL and RDTs. However, anti-malarial stock-outs in the previous three months were common, clinical supervision was infrequent, and HWs had important knowledge gaps. Except for fever history, clinical assessments were often incomplete. Although testing was recommended for all patients with suspected malaria, only 30.7% of such patients were tested. Correct testing was significantly associated with caseloads < 25 patients/day (odds ratio: 18.4; p < 0.0001) and elevated patient temperature (odds ratio: 2.5 per 1°C increase; p = 0.007). Testing was more common among AL-trained HWs, but the association was borderline significant (p = 0.072). When the malaria test was negative, HWs often diagnosed patients with malaria (57.8%) and prescribed anti-malarials (60.0%). Sixty-six percent of malaria-related diagnoses were correct, 20.1% were minor errors, and 13.9% were major (potentially life-threatening) errors. Only 49.0% of malaria treatments were correct, 5.4% were minor errors, and 45.6% were major errors. HWs almost always dosed AL correctly and gave accurate dosing instructions to patients; however, other aspects of counseling needed improvement. Conclusion By late-2007, substantial progress had been made to implement the malaria case-management policy in a setting with weak infrastructure. However, policy ambiguities, under-use of malaria testing, and distrust of negative test results led to many incorrect malaria diagnoses and treatments. In 2009, Angola published a policy that clarified many issues. As problems identified in this survey are not unique to Angola, better strategies for improving HW performance are urgently needed.
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- 2009
39. A qualitative exploration of care-seeking pathways for sick children in the rural Oromia region of Ethiopia
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Nathan P Miller, Agbessi Amouzou, Jennifer Bryce, Bryan Shaw, and Pamela J. Surkan
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Male ,medicine.medical_specialty ,Health care utilization ,Child Health Services ,Decision Making ,Health Behavior ,Psychological intervention ,Rural Health ,Careseeking ,Trust ,Health administration ,03 medical and health sciences ,0302 clinical medicine ,Nursing ,Qualitative research ,Health care ,Humans ,Medicine ,Community Health Services ,030212 general & internal medicine ,Child ,Child health ,Community Health Workers ,Delivery of Health Care, Integrated ,business.industry ,030503 health policy & services ,Public health ,Nursing research ,Health Policy ,Uncertainty ,Focus Groups ,Patient Acceptance of Health Care ,Rural communities ,Focus group ,Caregivers ,Community health ,Health Resources ,Female ,Ethiopia ,Rural Health Services ,0305 other medical science ,business ,Case Management ,Research Article - Abstract
Background Ethiopia has experienced rapid improvements in its healthcare infrastructure, such as through the recent scale up of integrated community case management (iCCM) delivered by community-based health extension workers (HEWs) targeting children under the age of five. Despite notable improvements in child outcomes, the use of HEWs delivering iCCM remains very low. The aim of our study was to explain this phenomenon by examining care-seeking practices and treatment for sick children in two rural districts in the Oromia Region of Ethiopia. Methods Using qualitative methods, we explored perceptions of child illness, influences on decision-making processes occurring over the course of a child’s illness and caregiver perceptions of available community-based sources of child illness care. Sixteen focus group discussions (FGDs) and 40 in-depth interviews (IDIs) were held with mothers of children under age five. For additional perspective, 16 IDIs were conducted fathers and 22 IDIs with health extension workers and community health volunteers. Results Caregivers often described the act of care-seeking for a sick child as a time of considerable uncertainty. In particular, mothers of sick children described the cultural, social and community-based resources available to minimize this uncertainty as well as constraints and strategies for accessing these resources in order to receive treatment for a sick child. The level of trust and familiarity were the most common dynamics noted as influencing care-seeking strategies; trust in biomedical and government providers was often low. Conclusions Overall, our research highlights the multiple and dynamic influences on care-seeking for sick children in rural Ethiopia. An understanding of these influences is critical for the success of existing and future health interventions and continued improvement of child health in Ethiopia. Electronic supplementary material The online version of this article (doi:10.1186/s12913-017-2123-5) contains supplementary material, which is available to authorized users.
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40. Insecticide-treated durable wall lining for malaria control: multicentre studies from Africa and South-East Asia
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Nathan P Miller, Abrahan Matias Arnez, Adedapo O Adeogun, Mark Rowland, Joseph B Stiles-Ocran, Ceg Mulder, Marie-Louise Larsen, Louisa A. Messenger, Mamadou B. Coulibaly, Hoan Le, and Immo Kleinschmidt
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Potential impact ,lcsh:Arctic medicine. Tropical medicine ,lcsh:RC955-962 ,business.industry ,Malaria vector control ,Indoor residual spraying ,medicine.disease ,lcsh:Infectious and parasitic diseases ,Toxicology ,Infectious Diseases ,Environmental protection ,Field trial ,Poster Presentation ,parasitic diseases ,medicine ,lcsh:RC109-216 ,Parasitology ,South east asia ,Netting ,business ,Malaria control ,Malaria - Abstract
Background Indoor residual spraying (IRS) is a primary method of malaria vector control but its potential impact is constrained by several inherent limitations: spraying must be repeated when insecticide residues decay, householders may object to the annual imposition and campaign costs are recurrent. Durable wall lining (DL) can be considered a novel form of long-lasting IRS, which gradually releases insecticide over a period of three to four years when used to cover interior house walls. DL is designed to overcome the logistical constraints associated with repeated rounds of spraying whilst retaining the most attractive feature of IRS, the protection of all members of the community [1-3]. To establish DL as a viable substitute it must demonstrate equivalent or superior levels of bioefficacy, acceptability, durability and logistical feasibility to currently available products. Materials and methods To identify a desirable material to develop into a durable wall lining, a one year preliminary trial was conducted among rural and urban households in Angola and Nigeria (n=258) comparing three deltamethrin-treated prototype materials (polyethylene shade cloth, laminated polyethylene sheeting and mosquito wall netting) [4]. The most popular lining material (shade cloth polyethylene, henceforth DL) was then evaluated in comparison with conventional IRS during a one year multicentre trial conducted in rural households in malaria endemic Equatorial Guinea, Ghana, Mali, South Africa and Vietnam (n=220). Results During the preliminary trial a dichotomy between rural and urban participants emerged. Rural households favoured wall adornments and accepted wall linings because of their perceived decorative value and entomological efficacy, whereas urban households preferred minimal wall decoration and objected to the materials aesthetics and installation feasibility. Of the prototype lining materials assessed, polyethylene shade cloth DL was the most popular because of its ease of installation, aesthetics and resemblance to locally available materials. During the multicentre field trial, DL demonstrated consistently higher levels of bioefficacy compared to IRS, with no significant loss of bioactivity after 12 months. Field samples of DL retained on average 78% of their original insecticide content after one year. The majority of households reported reductions in mosquito density (93%) and biting (82%), but no adverse changes to their indoor environment (83%). When offered a choice of vector control product at the end of trial, the majority of participants chose DL regardless of the earlier household allocation.
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41. The development of insecticide-treated durable wall lining for malaria control: insights from rural and urban populations in Angola and Nigeria
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Nathan P Miller, Adedapo O Adeogun, Mark Rowland, Louisa A. Messenger, and T. S. Awolola
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Rural Population ,Insecticides ,medicine.medical_specialty ,Mosquito Control ,lcsh:Arctic medicine. Tropical medicine ,Urban Population ,Malaria control ,lcsh:RC955-962 ,Durable wall lining ,Indoor residual spraying ,Nigeria ,Pilot Projects ,lcsh:Infectious and parasitic diseases ,Acceptability ,Environmental protection ,Surveys and Questionnaires ,medicine ,Animals ,Humans ,lcsh:RC109-216 ,Netting ,Socioeconomics ,Consumer group ,Research ,Public health ,Insecticide-treated plastic sheeting ,Focus Groups ,Patient Acceptance of Health Care ,Focus group ,Malaria ,Mosquito control ,Geography ,Infectious Diseases ,Angola ,ZeroVector® ,Parasitology ,Rural population - Abstract
Background Durable lining (DL) is a deltamethrin-impregnated polyethylene material, which is designed to cover domestic walls that would normally be sprayed with residual insecticide. The operational success of DL as a long-lasting insecticidal substrate will be dependent on a high level of user acceptability as households must maintain correctly installed linings on their walls for several years. Preliminary trials were undertaken to identify a material to develop into a marketable wall lining and to assess its level of acceptability among rural and urban populations. Methods In Angola (n=60), prototype DL and insecticide-treated plastic sheeting (ITPS) were installed on urban house walls and ceilings, respectively, and acceptability was compared to indoor residual spraying (IRS) (n=20) using a knowledge, attitude and practice (KAP) questionnaire. In Nigeria (n=178), three materials (prototype DL, ITPS and insecticide-treated wall netting) were distributed among rural and urban households. User opinions were gathered from focus group discussions, in-depth interviews and KAP questionnaires. Results In Angola, after two weeks, the majority of participants (98%) expressed satisfaction with the products and identified the killing of insects as the materials’ principal benefits (73%). After one year, despite a loss of almost 50% of households to refugee repatriation, all 32 remaining households still asserted that they had liked the DL/ITPS in their homes and given the choice of intervention preferred DL/ITPS to IRS (94%) or insecticide-treated nets (78%). In Nigeria, a dichotomy between rural and urban respondents emerged. Rural participants favoured wall adornments and accepted wall linings because of their perceived decorative value and entomological efficacy. By contrast, urban households preferred minimal wall decoration and rejected the materials based upon objections to their aesthetics and installation feasibility. Conclusions The high level of acceptability among rural inhabitants in Nigeria identifies these communities as the ideal target consumer group for durable wall linings. The poorer compliance among urban participants suggests that wall linings would not be readily adopted or sustained in these regions. If DL is as well received by other rural populations it could overcome some of the logistical constraints associated with spray campaigns and has the potential to become a long-lasting alternative to IRS in malaria endemic areas.
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42. Iatrogenic thrombosis of the deep inferior epigastric artery during diagnostic angiography—a rare complicating factor during rectus free flap harvest
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Christopher G. Langhammer, MD, PhD, Nathan F. Miller, MD, Carl L. Herndon, MD, Allen P. Burke, MD, Rishi Kundi, MD, and Raymond A. Pensy, MD
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Limb salvage ,Rectus abdominis free flap ,Angiogram ,Pedicle thrombus ,Flap salvage ,Surgery ,RD1-811 ,Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
We describe a 28-year-old man who sustained an open IIIB left ankle fracture dislocation with heel pad avulsion. The patient underwent formal angiography of the left lower extremity, followed by free tissue transfer of a rectus abdominis flap several days later. Intraoperatively, a thrombus was identified in the deep inferior epigastric artery above the femoral artery access site requiring thrombectomy. Histologic analysis estimated the thrombus age at 12 to 72 hours, raising concern that the thrombus was induced during angiogram instrumentation. Donor and recipient site-specific risks of arterial instrumentation (including invasive diagnostics) should be considered when planning free tissue transfer.
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- 2022
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43. A quantum Hopfield associative memory implemented on an actual quantum processor
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Nathan Eli Miller and Saibal Mukhopadhyay
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Medicine ,Science - Abstract
Abstract In this work, we present a Quantum Hopfield Associative Memory (QHAM) and demonstrate its capabilities in simulation and hardware using IBM Quantum Experience.. The QHAM is based on a quantum neuron design which can be utilized for many different machine learning applications and can be implemented on real quantum hardware without requiring mid-circuit measurement or reset operations. We analyze the accuracy of the neuron and the full QHAM considering hardware errors via simulation with hardware noise models as well as with implementation on the 15-qubit ibmq_16_melbourne device. The quantum neuron and the QHAM are shown to be resilient to noise and require low qubit overhead and gate complexity. We benchmark the QHAM by testing its effective memory capacity and demonstrate its capabilities in the NISQ-era of quantum hardware. This demonstration of the first functional QHAM to be implemented in NISQ-era quantum hardware is a significant step in machine learning at the leading edge of quantum computing.
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- 2021
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44. Barriers to the uptake of community-based curative child health services in Ethiopia
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Birkety Mengistu, Meron Paulos, Nesibu Agonafir, Agazi Ameha, Hailemariam Legesse, Elizabeth Dankenbring, Mariame Sylla, and Nathan P. Miller
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Barrier analysis ,Community-based newborn care ,Health extension program ,Health extension workers ,Integrated community case management ,Ethiopia ,Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background Uptake of services to treat newborns and children has been persistently low in Ethiopia, despite being provided free-of-charge by Health Extension Workers (HEWs). In order to increase the uptake of these services, the Optimizing the Health Extension Project was designed to be implemented in four regions in Ethiopia. This study was carried out to identify barriers to the uptake of these services and potential solutions to inform the project. Methods Qualitative data were collected in October and November 2015 in 15 purposely selected districts in four regions. We conducted 90 focus group discussions and 60 in-depth interviews reaching a total of 664 participants. Thematic analysis was used to identify key barriers and potential solutions. Results Five demand-side barriers to utilization of health services were identified. Misconceptions about illness causation, compounded with preference for traditional healers has affected service uptake. Limited awareness of the availability of free curative services for children at health posts; along with the prevailing perception that HEWs were providing preventive services only had constrained uptake. Geographic challenge that made access to the health post difficult was the other barrier. Four supply-side barriers were identified. Health post closure and drug stock-out led to inconsistent availability of services. Limited confidence and skill among HEWs and under-resourced physical facilities affected the service delivery. Study participants suggested demand creation solutions such as increasing community awareness on curative service availability and educating them on childhood illness causation. Maintaining consistent supplies and ensuring service availability; along with regular support to build HEWs’ confidence were the suggested supply-side solutions. Creating community feedback mechanisms was suggested as a way of addressing community concerns on the health services. Conclusion This study explored nine demand- and supply-side barriers that decreased the uptake of community-based services. It indicated the importance of increasing awareness of new services and addressing prevailing barriers that deprioritize health services. At the same time, supply-side barriers would have to be tackled by strengthening the health system to uphold newly introduced services and harness sustainable impact.
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- 2021
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45. Technique for Reconstruction of Midcarpal Instability Associated with Lunotriquetral Coalition
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Shannon M. Hall, BA, Frank G. Lee, MD, Sean J. Wallace, MD, and Nathan F. Miller, MD
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Surgery ,RD1-811 - Abstract
Summary:. Carpal coalition is a rare congenital presentation of 2 or more fused carpal bones due to a failure of apoptotic segmentation during development. The most common subtype is lunotriquetral coalition (LTC). Most cases are asymptomatic and found incidentally on imaging; however, a few symptomatic cases requiring treatment have been reported. Surgical intervention of arthrodesis and proximal row carpectomy in adults have been reported where conservative management of splinting, physiotherapy, anti-inflammatory medication, or steroid injections have failed. We report a unique case of Minnaar type 2 LTC in a 20-year-old man with a 6-year history of daily right wrist pain and symptomatic wrist instability whose previous conservative therapies failed. Midcarpal instability and volar intercalated segment instability—volar flexion of the lunate—were present. A novel technique using the palmaris longus tendon to reconstruct the triquetrohamate, triquetrocapitate, and dorsal radiolunate ligaments was performed. The graft was secured dorsally to the hamate, triquetrum, and capitate. An additional graft from the lunate to distal radius acted as a biomechanical checkrein. There were no complications. Temporary Kirschner wires were removed 2 months postoperatively, followed by occupational hand therapy. At 1-year follow-up, the patient no longer reported pain or lunotriquetral tenderness. Midcarpal instability and volar intercalated segment instability resolved. Postoperative right wrist flexion and extension were 40 and 75 degrees, respectively. We discuss the successful outcome of this novel technique as an alternative to arthrodesis in the surgical management of LTC.
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- 2022
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46. Maize genomes to fields (G2F): 2014–2017 field seasons: genotype, phenotype, climatic, soil, and inbred ear image datasets
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Bridget A. McFarland, Naser AlKhalifah, Martin Bohn, Jessica Bubert, Edward S. Buckler, Ignacio Ciampitti, Jode Edwards, David Ertl, Joseph L. Gage, Celeste M. Falcon, Sherry Flint-Garcia, Michael A. Gore, Christopher Graham, Candice N. Hirsch, James B. Holland, Elizabeth Hood, David Hooker, Diego Jarquin, Shawn M. Kaeppler, Joseph Knoll, Greg Kruger, Nick Lauter, Elizabeth C. Lee, Dayane C. Lima, Aaron Lorenz, Jonathan P. Lynch, John McKay, Nathan D. Miller, Stephen P. Moose, Seth C. Murray, Rebecca Nelson, Christina Poudyal, Torbert Rocheford, Oscar Rodriguez, Maria Cinta Romay, James C. Schnable, Patrick S. Schnable, Brian Scully, Rajandeep Sekhon, Kevin Silverstein, Maninder Singh, Margaret Smith, Edgar P. Spalding, Nathan Springer, Kurt Thelen, Peter Thomison, Mitchell Tuinstra, Jason Wallace, Ramona Walls, David Wills, Randall J. Wisser, Wenwei Xu, Cheng-Ting Yeh, and Natalia de Leon
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Maize ,Genome ,Genotype ,GBS ,G × E ,Hybrid ,Medicine ,Biology (General) ,QH301-705.5 ,Science (General) ,Q1-390 - Abstract
Abstract Objectives Advanced tools and resources are needed to efficiently and sustainably produce food for an increasing world population in the context of variable environmental conditions. The maize genomes to fields (G2F) initiative is a multi-institutional initiative effort that seeks to approach this challenge by developing a flexible and distributed infrastructure addressing emerging problems. G2F has generated large-scale phenotypic, genotypic, and environmental datasets using publicly available inbred lines and hybrids evaluated through a network of collaborators that are part of the G2F’s genotype-by-environment (G × E) project. This report covers the public release of datasets for 2014–2017. Data description Datasets include inbred genotypic information; phenotypic, climatic, and soil measurements and metadata information for each testing location across years. For a subset of inbreds in 2014 and 2015, yield component phenotypes were quantified by image analysis. Data released are accompanied by README descriptions. For genotypic and phenotypic data, both raw data and a version without outliers are reported. For climatic data, a version calibrated to the nearest airport weather station and a version without outliers are reported. The 2014 and 2015 datasets are updated versions from the previously released files [1] while 2016 and 2017 datasets are newly available to the public.
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- 2020
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47. Otolith geochemistry reflects life histories of Pacific bluefin tuna
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John A. Mohan, Heidi Dewar, Owyn E. Snodgrass, Nathan R. Miller, Yosuke Tanaka, Seiji Ohshimo, Jay R. Rooker, Malcom Francis, and R. J. David Wells
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Medicine ,Science - Abstract
Understanding biological and environmental factors that influence movement behaviors and population connectivity of highly migratory fishes is essential for cooperative international management and conservation of exploited populations, like bluefin tuna. Pacific bluefin tuna Thunnus orientalis (PBT) spawn in the western Pacific Ocean and then juveniles disperse to foraging grounds across the North Pacific. Several techniques have been used to characterize the distribution and movement of PBT, but few methods can provide complete records across ontogeny from larvae to adult in individual fish. Here, otolith biominerals of large PBT collected from the western, eastern, and south Pacific Ocean, were analyzed for a suite of trace elements across calcified/proteinaceous growth zones to investigate patterns across ontogeny. Three element:Ca ratios, Li:Ca, Mg:Ca, and Mn:Ca displayed enrichment in the otolith core, then decreased to low stable levels after age 1–2 years. Thermal and metabolic physiologies, common diets, or ambient water chemistry likely influenced otolith crystallization, protein content, and elemental incorporation in early life. Although similar patterns were also exhibited for otolith Sr:Ca, Ba:Ca and Zn:Ca in the first year, variability in these elements differed significantly after age-2 and in the otolith edges by capture region, suggesting ocean-specific environmental factors or growth-related physiologies affected otolith mineralization across ontogeny.
- Published
- 2022
48. Conservative Management of Median Nerve Brachial Plexopathy after Microwave-based MiraDry Treatment for Axillary Hyperhidrosis
- Author
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Frank G. Lee, BSE, Ahmed M. Mansour, MD, Sean J. Wallace, MD, and Nathan F. Miller, MD
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Surgery ,RD1-811 - Abstract
Summary:. Axillary hyperhidrosis is characterized by excessive sweating of the armpits, which can significantly affect quality of life. A new microwave-based therapy, MiraDry (Miramar labs, Sunnyvale, Calif.), is a promising minimally-invasive treatment option. We report a case of unilateral brachial plexus thermal injury in a thin 19-year-old man treated for axillary hyperhidrosis with the MiraDry system. He initially experienced swelling and pain in the left hand and was prescribed 1 week of methylprednisolone. He then presented 1 week later with induration and swelling of bilateral axillae with swelling of left thumb, left index, and left long fingers, decreased sensation in median nerve distribution of the left hand, and the inability to flex the left index finger DIP joint. EMG showed absent median nerve motor and sensory function, consistent with median nerve plexopathy. He was conservatively managed with close observation and regular occupational hand therapy appointments. At his 12-month follow-up, there was complete return of left pronator teres strength, thumb flexion, and index finger flexion. Decreased sensation remained at the tip of the left index finger. We report the case of median nerve palsy after MiraDry therapy for axillary hyperhidrosis in a thin young man. We recommend using low-energy settings and pre-procedural ultrasound for young, thin patients because of the more superficial course of the brachial plexus within the axilla.
- Published
- 2021
- Full Text
- View/download PDF
49. Ontogenetic Patterns of Elemental Tracers in the Vertebrae Cartilage of Coastal and Oceanic Sharks
- Author
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Mariah C. Livernois, John A. Mohan, Thomas C. TinHan, Travis M. Richards, Brett J. Falterman, Nathan R. Miller, and R. J. David Wells
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trace elements ,vertebrae ,ontogeny ,sharks ,habitat use ,movement ,Science ,General. Including nature conservation, geographical distribution ,QH1-199.5 - Abstract
As predators, coastal and oceanic sharks play critical roles in shaping ecosystem structure and function, but most shark species are highly susceptible to population declines. Effective management of vulnerable shark populations requires knowledge of species-specific movement and habitat use patterns. Since sharks are often highly mobile and long-lived, tracking their habitat use patterns over large spatiotemporal scales is challenging. However, the analysis of elemental tracers in vertebral cartilage can describe a continuous record of the life history of an individual from birth to death. This study examined trace elements (Li, Mg, Mn, Zn, Sr, and Ba) along vertebral transects of five shark species with unique life histories. From most freshwater-associated to most oceanic, these species include Bull Sharks (Carcharhinus leucas), Bonnethead Sharks (Sphyrna tiburo), Blacktip Sharks (Carcharhinus limbatus), Spinner Sharks (Carcharhinus brevipinna), and Shortfin Mako Sharks (Isurus oxyrinchus). Element concentrations were compared across life stages (young-of-the-year, early juvenile, late juvenile, and adult) to infer species-specific ontogenetic patterns of habitat use and movement. Many of the observed elemental patterns could be explained by known life history traits: C. leucas exhibited clear ontogenetic changes in elemental composition matching expected changes in their use of freshwater habitats over time. S. tiburo elemental composition did not differ across ontogeny, suggesting residence in estuarine/coastal regions. The patterns of elemental composition were strikingly similar between C. brevipinna and C. limbatus, suggesting they co-occur in similar habitats across ontogeny. I. oxyrinchus elemental composition was stable over time, but some ontogenetic shifts occurred that may be due to changes in migration patterns with maturation. The results presented in this study enhance our understanding of the habitat use and movement patterns of coastal and oceanic sharks, and highlights the applicability of vertebral chemistry as a tool for characterizing shark life history traits.
- Published
- 2021
- Full Text
- View/download PDF
50. Regulation of Root Angle and Gravitropism
- Author
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Ted W. Toal, Mily Ron, Donald Gibson, Kaisa Kajala, Bessie Splitt, Logan S. Johnson, Nathan D. Miller, Radka Slovak, Allison Gaudinier, Rohan Patel, Miguel de Lucas, Nicholas J. Provart, Edgar P. Spalding, Wolfgang Busch, Daniel J. Kliebenstein, and Siobhan M. Brady
- Subjects
gravitropism ,root ,tomato ,Genetics ,QH426-470 - Abstract
Regulation of plant root angle is critical for obtaining nutrients and water and is an important trait for plant breeding. A plant’s final, long-term root angle is the net result of a complex series of decisions made by a root tip in response to changes in nutrient availability, impediments, the gravity vector and other stimuli. When a root tip is displaced from the gravity vector, the short-term process of gravitropism results in rapid reorientation of the root toward the vertical. Here, we explore both short- and long-term regulation of root growth angle, using natural variation in tomato to identify shared and separate genetic features of the two responses. Mapping of expression quantitative trait loci mapping and leveraging natural variation between and within species including Arabidopsis suggest a role for PURPLE ACID PHOSPHATASE 27 and CELL DIVISION CYCLE 73 in determining root angle.
- Published
- 2018
- Full Text
- View/download PDF
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