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Your search keyword '"Nathan L Lawrentschuk"' showing total 2 results
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2 results on '"Nathan L Lawrentschuk"'

1. Updates of prostate cancer staging: Prostate-specific membrane antigen

Author

Niranjan J Sathianathen, Alastair Lamb, Rajesh Nair, Nicolas Geurts, Catherine Mitchell, Nathan L Lawrentschuk, Daniel A Moon, and Declan G Murphy

Subjects
Local neoplasm recurrence, Positron-emission tomography, Prostatic neoplasms, X-ray computed tomography, Diseases of the genitourinary system. Urology, RC870-923
Abstract

The ability to accurately stage prostate cancer in both the primary and secondary staging setting can have a major impact on management. Until recently radiological staging has relied on computer tomography, magnetic resonance imaging, and nuclear bone scans to evaluate the extent of disease. However, the utility of these imaging technologies has been limited by their sensitivity and specificity especially in detecting early recurrence. Functional imaging using positron-emission tomography with a radiolabeled ligand targeted to prostate-specific membrane antigen has transformed the prostate cancer imaging landscape. Initial results suggest that it is a substantial improvement over conventional imaging in the setting of recurrence following primary therapy by having a superior ability to detect disease and to do so at an earlier stage. Additionally, it appears that the benefits seen in the secondary staging setting may also exist in the primary staging setting.

Published
2016
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2. Changing face of robot-assisted radical prostatectomy in Melbourne over 12 years

Author

Niranjan J, Sathianathen, Alastair D, Lamb, Nathan L, Lawrentschuk, Jeremy R, Goad, Justin, Peters, Anthony J, Costello, Declan G, Murphy, and Daniel A, Moon

Subjects
Male, Prostatectomy, Robotic Surgical Procedures, Patient Selection, Age Factors, Australia, Humans, Prostatic Neoplasms, Middle Aged, Neoplasm Grading, Aged, Neoplasm Staging
Abstract

This study aims to characterize the trends in disease presentation for robot-assisted radical prostatectomy (RARP) over a 12-year period in Melbourne, Australia.All patients undergoing an RARP between 2004 and October 2016 while under the care of six high-volume surgeons were included in this study. Data were collected prospectively regarding patient demographics and clinical details of their cancer.Over the 12-year time span of the study, 3075 men underwent an RARP with a median age of 63.01 years. Temporal analysis demonstrated that the median age of patients undergoing prostatectomy advanced with time with the median age in 2016 being 65.51 years compared with 61.0 years in 2004 (P0.001). There was also a significant trend to increased D'Amico risk groups over time with the percentage procedures for high-risk patients increasing from 12.6% to 28.10% from 2004 to 2016 (P0.001). Upgrade rates between biopsy and pathological Gleason grade scoring significantly trended down over the period of the study (P0.001). There was also a shift to increased pathological stage over the 12 years with 22.1% of men having T3 disease in 2004 compared with 49.8% in 2016.Our analysis demonstrates increasing treatment of older men with higher risk tumours, consistent with international trends. While this largely reflects a shift in case selection, further work is needed to assess whether the stage shift may relate partially to a decline in screening and increased presentation of higher risk disease.

Published
2017

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