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7. Event-free survival of maralixibat-treated patients with Alagille syndrome compared to a real-world cohort from GALA

Author

Hansen, B, Vandriel, S, Vig, P, Garner, W, Mogul, D, Loomes, K, Piccoli, D, Rand, E, Jankowska, I, Czubkowski, P, Gliwicz-Miedzinska, D, Gonzales, E, Jacquemin, E, Bouligand, J, D'Antiga, L, Nicastro, E, Arnell, H, Fischler, B, Sokal, E, Demaret, T, Siew, S, Stormon, M, Karpen, S, Romero, R, Ebel, N, Feinstein, J, Roberts, A, Evans, H, Sundaram, S, Chaidez, A, Hardikar, W, Shankar, S, Fischer, R, Lacaille, F, Debray, D, Lin, H, Jensen, M, Jaramillo, C, Karthikeyan, P, Indolfi, G, Verkade, H, Larson-Nath, C, Quiros-Tejeira, R, Valentino, P, Rogalidou, M, Dezsofi, A, Squires, J, Schwarz, K, Calvo, P, Bernabeu, J, Zizzo, A, Nebbia, G, Bulut, P, Santos-Silva, E, Fawaz, R, Nastasio, S, Karnsakul, W, Tamara, M, Busoms, C, Kelly, D, Sandahl, T, Jimenez-Rivera, C, Banales, J, Mujawar, Q, Li, L, She, H, Wang, J, Kim, K, Oh, S, Sanchez, M, Cavalieri, M, Lee, W, Hajinicolaou, C, Lertudomphonwanit, C, Waisbourd-Zinman, O, Arikan, C, Alam, S, Carvalho, E, Melere, M, Eshun, J, Onal, Z, Desai, D, Wiecek, S, Pinto, R, Wolters, V, Garcia, J, Beretta, M, Kerkar, N, Brecelj, J, Rock, N, Lurz, E, Blondet, N, Shah, U, Thompson, R, Kamath, B, Hansen B. E., Vandriel S. M., Vig P., Garner W., Mogul D. B., Loomes K. M., Piccoli D. A., Rand E. B., Jankowska I., Czubkowski P., Gliwicz-Miedzinska D., Gonzales E. M., Jacquemin E., Bouligand J., D'Antiga L., Nicastro E., Arnell H., Fischler B., Sokal E., Demaret T., Siew S., Stormon M., Karpen S. J., Romero R., Ebel N. H., Feinstein J. A., Roberts A. J., Evans H. M., Sundaram S. S., Chaidez A., Hardikar W., Shankar S., Fischer R. T., Lacaille F., Debray D., Lin H. C., Jensen M. K., Jaramillo C., Karthikeyan P., Indolfi G., Verkade H. J., Larson-Nath C., Quiros-Tejeira R. E., Valentino P. L., Rogalidou M., Dezsofi A., Squires J. E., Schwarz K., Calvo P. L., Bernabeu J. Q., Zizzo A. N., Nebbia G., Bulut P., Santos-Silva E., Fawaz R., Nastasio S., Karnsakul W., Tamara M. L., Busoms C. M., Kelly D. A., Sandahl T. D., Jimenez-Rivera C., Banales J. M., Mujawar Q., Li L. -T., She H., Wang J. -S., Kim K. M., Oh S. H., Sanchez M. C., Cavalieri M. L., Lee W. S., Hajinicolaou C., Lertudomphonwanit C., Waisbourd-Zinman O., Arikan C., Alam S., Carvalho E., Melere M., Eshun J., Onal Z., Desai D. M., Wiecek S., Pinto R. B., Wolters V. M., Garcia J., Beretta M., Kerkar N., Brecelj J., Rock N., Lurz E., Blondet N., Shah U., Thompson R. J., Kamath B. M., Hansen, B, Vandriel, S, Vig, P, Garner, W, Mogul, D, Loomes, K, Piccoli, D, Rand, E, Jankowska, I, Czubkowski, P, Gliwicz-Miedzinska, D, Gonzales, E, Jacquemin, E, Bouligand, J, D'Antiga, L, Nicastro, E, Arnell, H, Fischler, B, Sokal, E, Demaret, T, Siew, S, Stormon, M, Karpen, S, Romero, R, Ebel, N, Feinstein, J, Roberts, A, Evans, H, Sundaram, S, Chaidez, A, Hardikar, W, Shankar, S, Fischer, R, Lacaille, F, Debray, D, Lin, H, Jensen, M, Jaramillo, C, Karthikeyan, P, Indolfi, G, Verkade, H, Larson-Nath, C, Quiros-Tejeira, R, Valentino, P, Rogalidou, M, Dezsofi, A, Squires, J, Schwarz, K, Calvo, P, Bernabeu, J, Zizzo, A, Nebbia, G, Bulut, P, Santos-Silva, E, Fawaz, R, Nastasio, S, Karnsakul, W, Tamara, M, Busoms, C, Kelly, D, Sandahl, T, Jimenez-Rivera, C, Banales, J, Mujawar, Q, Li, L, She, H, Wang, J, Kim, K, Oh, S, Sanchez, M, Cavalieri, M, Lee, W, Hajinicolaou, C, Lertudomphonwanit, C, Waisbourd-Zinman, O, Arikan, C, Alam, S, Carvalho, E, Melere, M, Eshun, J, Onal, Z, Desai, D, Wiecek, S, Pinto, R, Wolters, V, Garcia, J, Beretta, M, Kerkar, N, Brecelj, J, Rock, N, Lurz, E, Blondet, N, Shah, U, Thompson, R, Kamath, B, Hansen B. E., Vandriel S. M., Vig P., Garner W., Mogul D. B., Loomes K. M., Piccoli D. A., Rand E. B., Jankowska I., Czubkowski P., Gliwicz-Miedzinska D., Gonzales E. M., Jacquemin E., Bouligand J., D'Antiga L., Nicastro E., Arnell H., Fischler B., Sokal E., Demaret T., Siew S., Stormon M., Karpen S. J., Romero R., Ebel N. H., Feinstein J. A., Roberts A. J., Evans H. M., Sundaram S. S., Chaidez A., Hardikar W., Shankar S., Fischer R. T., Lacaille F., Debray D., Lin H. C., Jensen M. K., Jaramillo C., Karthikeyan P., Indolfi G., Verkade H. J., Larson-Nath C., Quiros-Tejeira R. E., Valentino P. L., Rogalidou M., Dezsofi A., Squires J. E., Schwarz K., Calvo P. L., Bernabeu J. Q., Zizzo A. N., Nebbia G., Bulut P., Santos-Silva E., Fawaz R., Nastasio S., Karnsakul W., Tamara M. L., Busoms C. M., Kelly D. A., Sandahl T. D., Jimenez-Rivera C., Banales J. M., Mujawar Q., Li L. -T., She H., Wang J. -S., Kim K. M., Oh S. H., Sanchez M. C., Cavalieri M. L., Lee W. S., Hajinicolaou C., Lertudomphonwanit C., Waisbourd-Zinman O., Arikan C., Alam S., Carvalho E., Melere M., Eshun J., Onal Z., Desai D. M., Wiecek S., Pinto R. B., Wolters V. M., Garcia J., Beretta M., Kerkar N., Brecelj J., Rock N., Lurz E., Blondet N., Shah U., Thompson R. J., and Kamath B. M.

Abstract

BACKGROUND AND AIMS: Alagille syndrome (ALGS) is characterized by chronic cholestasis with associated pruritus and extrahepatic anomalies. Maralixibat, an ileal bile acid transporter inhibitor, is an approved pharmacologic therapy for cholestatic pruritus in ALGS. Since long-term placebo-controlled studies are not feasible or ethical in children with rare diseases, a novel approach was taken comparing 6-year outcomes from maralixibat trials with an aligned and harmonized natural history cohort from the G lobal AL agille A lliance (GALA) study. APPROACH AND RESULTS: Maralixibat trials comprise 84 patients with ALGS with up to 6 years of treatment. GALA contains retrospective data from 1438 participants. GALA was filtered to align with key maralixibat eligibility criteria, yielding 469 participants. Serum bile acids could not be included in the GALA filtering criteria as these are not routinely performed in clinical practice. Index time was determined through maximum likelihood estimation in an effort to align the disease severity between the two cohorts with the initiation of maralixibat. Event-free survival, defined as the time to first event of manifestations of portal hypertension (variceal bleeding, ascites requiring therapy), surgical biliary diversion, liver transplant, or death, was analyzed by Cox proportional hazards methods. Sensitivity analyses and adjustments for covariates were applied. Age, total bilirubin, gamma-glutamyl transferase, and alanine aminotransferase were balanced between groups with no statistical differences. Event-free survival in the maralixibat cohort was significantly better than the GALA cohort (HR, 0.305; 95% CI, 0.189-0.491; p <0.0001). Multiple sensitivity and subgroup analyses (including serum bile acid availability) showed similar findings. CONCLUSIONS: This study demonstrates a novel application of a robust statistical method to evaluate outcomes in long-term intervention studies where placebo comparisons are not feasible, p

Published
2024

9. Association study of candidate DNA-repair gene variants and acute graft versus host disease in pediatric patients receiving allogeneic hematopoietic stem-cell transplantation

Author

Uppugunduri, C. R. S., Huezo-Diaz Curtis, P., Nava, T., Rezgui, M. A., Mlakar, V., Mlakar, S. Jurkovic, Waespe, N., Théoret, Y., Gumy-Pause, F., Bernard, F., Chalandon, Y., Boelens, J. J., Bredius, R. G. M., Dalle, J. H., Nath, C., Corbacioglu, S., Peters, C., Bader, P., Shaw, P., Bittencourt, H., Krajinovic, M., and Ansari, M.

Published
2022
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11. Yield Trait and Stability of Chickpea Genotypes for Intensification of Drought‐Prone Rice Fallows of South Asia.

Author

Nath, C. P., Jha, U. C., Kumar, Narendra, Singh, Raghavendra, Kumar, Yogesh, Dixit, G. P., Hazra, K. K., and Srivastava, A. K.

Subjects
*CHICKPEA, *GENOTYPES, *FALLOWING, *RICE, *GENETIC variation, *SEED yield, *PLANT drying
Abstract

There is a need for increasing cropping intensity in South Asia including India to ensure food security of burgeoning population. Accordingly, increasing cropping intensity in rainfed rice fallows can be a futuristic strategy. Identification of suitable cultivar and exploration of genetic variability of specific crops/traits are imperative for genetic improvement, drought resistance and yield gain in rice fallows. We evaluated the morphophysiological, yield traits and stability of 15 chickpea genotypes in randomised complete block design for three consecutive years on a drought‐prone rainfed condition of Fluvisol in Kanpur, India. Among genotypes, 'IPC 2014‐55', 'IPC 2015‐44' and 'IPC 2011‐92' had 2%–10% higher relative water content (RWC) over 'ICC‐92944' (check cultivar). These genotypes did not differ for total chlorophyll content, root dry weight and nodule dry weight with 'ICC‐92944' and 'KWR 108' (wider adaptable cultivar of the region). The nitrogen balance index was higher in 'IPC 2011‐92', 'IPC 2014‐88' and 'IPC 2014‐55' by 5%–44% over check cultivar (p < 0.05). The membrane stability index was higher for 'IPC 2014‐55' (30%, p < 0.05) and 'IPC 2011‐92' (17%, p < 0.05) than 'ICC‐92944'. 'IPC 2011‐92', 'IPC 2014‐88' and 'IPC 2014‐55' (3 years mean) had 3%–24% higher plant dry weight than 'ICC‐92944'. Notably, 'IPC 2014‐55', 'IPC 2015‐44', 'IPC 2014‐88' and 'IPC 2011‐92' had higher yield attributes such as pods plant−1 by 9%, grain weight plant−1 by 13% and 100‐seed weight by 3% than 'ICC‐92944' and 'KWR 108' (mean of years). These genotypes had higher mean seed yield than 'ICC‐92944' by 23%–42% and 'KWR 108' by 7%–23% (p < 0.05). The yield of 'IPC 2014‐55', 'IPC 2015‐44', 'IPC 2014‐88' and 'IPC 2011‐92' were stable over years across variable soil and environmental condition as indicated by the genotype × year biplot. Membrane stability index, pods plant−1 and 100‐seed weight were the determinants for increased seed yield of chickpea under drought‐prone condition. Evidently, genotype 'IPC 2014‐55', 'IPC 2015‐44', 'IPC 2014‐88' and 'IPC 2011‐92' were better under rainfed rice fallows. These genotypes could be tested under specific drought condition for developing varieties and promoted in rice fallows of South Asia for yield advantage and drought resistance. [ABSTRACT FROM AUTHOR]

Published
2024
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12. Natural history of liver disease in a large international cohort of children with Alagille syndrome: Results from the GALA study

Author

Vandriel, S, Li, L, She, H, Wang, J, Gilbert, M, Jankowska, I, Czubkowski, P, Gliwicz-Miedzinska, D, Gonzales, E, Jacquemin, E, Bouligand, J, Spinner, N, Loomes, K, Piccoli, D, D'Antiga, L, Nicastro, E, Sokal, A, Demaret, T, Ebel, N, Feinstein, J, Fawaz, R, Nastasio, S, Lacaille, F, Debray, D, Arnell, H, Fischler, B, Siew, S, Stormon, M, Karpen, S, Romero, R, Kim, K, Baek, W, Hardikar, W, Shankar, S, Roberts, A, Evans, H, Jensen, M, Kavan, M, Sundaram, S, Chaidez, A, Karthikeyan, P, Sanchez, M, Cavalieri, M, Verkade, H, Lee, W, Squires, J, Hajinicolaou, C, Lertudomphonwanit, C, Fischer, R, Larson-Nath, C, Mozer-Glassberg, Y, Arikan, C, Lin, H, Bernabeu, J, Alam, S, Kelly, D, Carvalho, E, Ferreira, C, Indolfi, G, Quiros-Tejeira, R, Bulut, P, Calvo, P, Anal, Z, Valentino, P, Desai, D, Eshun, J, Rogalidou, M, Dezsofi, A, Wiecek, S, Nebbia, G, Pinto, R, Wolters, V, Tamara, M, Zizzo, A, Garcia, J, Schwarz, K, Beretta, M, Sandahl, T, Jimenez-Rivera, C, Kerkar, N, Brecelj, J, Mujawar, Q, Rock, N, Busoms, C, Karnsakul, W, Lurz, E, Santos-Silva, E, Blondet, N, Bujanda, L, Shah, U, Thompson, R, Hansen, B, Kamath, B, Vandriel S. M., Li L. -T., She H., Wang J. -S., Gilbert M. A., Jankowska I., Czubkowski P., Gliwicz-Miedzinska D., Gonzales E. M., Jacquemin E., Bouligand J., Spinner N. B., Loomes K. M., Piccoli D. A., D'Antiga L., Nicastro E., Sokal A., Demaret T., Ebel N. H., Feinstein J. A., Fawaz R., Nastasio S., Lacaille F., Debray D., Arnell H., Fischler B., Siew S., Stormon M., Karpen S. J., Romero R., Kim K. M., Baek W. Y., Hardikar W., Shankar S., Roberts A. J., Evans H. M., Jensen M. K., Kavan M., Sundaram S. S., Chaidez A., Karthikeyan P., Sanchez M. C., Cavalieri M. L., Verkade H. J., Lee W. S., Squires J. E., Hajinicolaou C., Lertudomphonwanit C., Fischer R. T., Larson-Nath C., Mozer-Glassberg Y., Arikan C., Lin H. C., Bernabeu J. Q., Alam S., Kelly D. A., Carvalho E., Ferreira C. T., Indolfi G., Quiros-Tejeira R. E., Bulut P., Calvo P. L., Anal Z., Valentino P. L., Desai D. M., Eshun J., Rogalidou M., Dezsofi A., Wiecek S., Nebbia G., Pinto R. B., Wolters V. M., Tamara M. L., Zizzo A. N., Garcia J., Schwarz K., Beretta M., Sandahl T. D., Jimenez-Rivera C., Kerkar N., Brecelj J., Mujawar Q., Rock N., Busoms C. M., Karnsakul W., Lurz E., Santos-Silva E., Blondet N., Bujanda L., Shah U., Thompson R. J., Hansen B. E., Kamath B. M., Vandriel, S, Li, L, She, H, Wang, J, Gilbert, M, Jankowska, I, Czubkowski, P, Gliwicz-Miedzinska, D, Gonzales, E, Jacquemin, E, Bouligand, J, Spinner, N, Loomes, K, Piccoli, D, D'Antiga, L, Nicastro, E, Sokal, A, Demaret, T, Ebel, N, Feinstein, J, Fawaz, R, Nastasio, S, Lacaille, F, Debray, D, Arnell, H, Fischler, B, Siew, S, Stormon, M, Karpen, S, Romero, R, Kim, K, Baek, W, Hardikar, W, Shankar, S, Roberts, A, Evans, H, Jensen, M, Kavan, M, Sundaram, S, Chaidez, A, Karthikeyan, P, Sanchez, M, Cavalieri, M, Verkade, H, Lee, W, Squires, J, Hajinicolaou, C, Lertudomphonwanit, C, Fischer, R, Larson-Nath, C, Mozer-Glassberg, Y, Arikan, C, Lin, H, Bernabeu, J, Alam, S, Kelly, D, Carvalho, E, Ferreira, C, Indolfi, G, Quiros-Tejeira, R, Bulut, P, Calvo, P, Anal, Z, Valentino, P, Desai, D, Eshun, J, Rogalidou, M, Dezsofi, A, Wiecek, S, Nebbia, G, Pinto, R, Wolters, V, Tamara, M, Zizzo, A, Garcia, J, Schwarz, K, Beretta, M, Sandahl, T, Jimenez-Rivera, C, Kerkar, N, Brecelj, J, Mujawar, Q, Rock, N, Busoms, C, Karnsakul, W, Lurz, E, Santos-Silva, E, Blondet, N, Bujanda, L, Shah, U, Thompson, R, Hansen, B, Kamath, B, Vandriel S. M., Li L. -T., She H., Wang J. -S., Gilbert M. A., Jankowska I., Czubkowski P., Gliwicz-Miedzinska D., Gonzales E. M., Jacquemin E., Bouligand J., Spinner N. B., Loomes K. M., Piccoli D. A., D'Antiga L., Nicastro E., Sokal A., Demaret T., Ebel N. H., Feinstein J. A., Fawaz R., Nastasio S., Lacaille F., Debray D., Arnell H., Fischler B., Siew S., Stormon M., Karpen S. J., Romero R., Kim K. M., Baek W. Y., Hardikar W., Shankar S., Roberts A. J., Evans H. M., Jensen M. K., Kavan M., Sundaram S. S., Chaidez A., Karthikeyan P., Sanchez M. C., Cavalieri M. L., Verkade H. J., Lee W. S., Squires J. E., Hajinicolaou C., Lertudomphonwanit C., Fischer R. T., Larson-Nath C., Mozer-Glassberg Y., Arikan C., Lin H. C., Bernabeu J. Q., Alam S., Kelly D. A., Carvalho E., Ferreira C. T., Indolfi G., Quiros-Tejeira R. E., Bulut P., Calvo P. L., Anal Z., Valentino P. L., Desai D. M., Eshun J., Rogalidou M., Dezsofi A., Wiecek S., Nebbia G., Pinto R. B., Wolters V. M., Tamara M. L., Zizzo A. N., Garcia J., Schwarz K., Beretta M., Sandahl T. D., Jimenez-Rivera C., Kerkar N., Brecelj J., Mujawar Q., Rock N., Busoms C. M., Karnsakul W., Lurz E., Santos-Silva E., Blondet N., Bujanda L., Shah U., Thompson R. J., Hansen B. E., and Kamath B. M.

Abstract

Background and Aims: Alagille syndrome (ALGS) is a multisystem disorder, characterized by cholestasis. Existing outcome data are largely derived from tertiary centers, and real-world data are lacking. This study aimed to elucidate the natural history of liver disease in a contemporary, international cohort of children with ALGS. Approach and Results: This was a multicenter retrospective study of children with a clinically and/or genetically confirmed ALGS diagnosis, born between January 1997 and August 2019. Native liver survival (NLS) and event-free survival rates were assessed. Cox models were constructed to identify early biochemical predictors of clinically evident portal hypertension (CEPH) and NLS. In total, 1433 children (57% male) from 67 centers in 29 countries were included. The 10 and 18-year NLS rates were 54.4% and 40.3%. By 10 and 18 years, 51.5% and 66.0% of children with ALGS experienced ≥1 adverse liver-related event (CEPH, transplant, or death). Children (>6 and ≤12 months) with median total bilirubin (TB) levels between ≥5.0 and <10.0 mg/dl had a 4.1-fold (95% confidence interval [CI], 1.6-10.8), and those ≥10.0 mg/dl had an 8.0-fold (95% CI, 3.4-18.4) increased risk of developing CEPH compared with those <5.0 mg/dl. Median TB levels between ≥5.0 and <10.0 mg/dl and >10.0 mg/dl were associated with a 4.8 (95% CI, 2.4-9.7) and 15.6 (95% CI, 8.7-28.2) increased risk of transplantation relative to <5.0 mg/dl. Median TB <5.0 mg/dl were associated with higher NLS rates relative to ≥5.0 mg/dl, with 79% reaching adulthood with native liver (p < 0.001). Conclusions: In this large international cohort of ALGS, only 40.3% of children reach adulthood with their native liver. A TB <5.0 mg/dl between 6 and 12 months of age is associated with better hepatic outcomes. These thresholds provide clinicians with an objective tool to assist with clinical decision-making and in the evaluation of therapies.

Published
2023

17. Impact of Antibodies Against Polyethylene Glycol on the Pharmacokinetics of PEGylated Asparaginase in Children with Acute Lymphoblastic Leukaemia: A Population Pharmacokinetic Approach

Author

Siebel, C, Lanvers-Kaminsky, C, Alten, J, Smisek, P, Nath, C, Rizzari, C, Boos, J, Wurthwein, G, Siebel C., Lanvers-Kaminsky C., Alten J., Smisek P., Nath C. E., Rizzari C., Boos J., Wurthwein G., Siebel, C, Lanvers-Kaminsky, C, Alten, J, Smisek, P, Nath, C, Rizzari, C, Boos, J, Wurthwein, G, Siebel C., Lanvers-Kaminsky C., Alten J., Smisek P., Nath C. E., Rizzari C., Boos J., and Wurthwein G.

Abstract

Background and Objectives: Besides allergic reactions, antibodies against polyethylene glycol (PEG) have been associated with reduced PEG-asparaginase (PEG-ASNase) activity. Population pharmacokinetics (popPK) allow for an in-depth investigation of the influence of anti-PEG antibodies on PEG-ASNase pharmacokinetics. Methods: PEG-ASNase activity (6261 samples) and anti-PEG antibodies (2082/6412 samples prior to/post administration) in 1444 children with acute lymphoblastic leukaemia treated in the AIEOP-BFM ALL 2009 trial were evaluated. Patients received two doses of PEG-ASNase during induction (2500 U/m2, intravenous, biweekly) and a third dose during reinduction treatment. Anti-PEG IgG and IgM measured prior to and post administration were explored for their influence on the initial clearance of PEG-ASNase using a previously established popPK model. Categorical and continuous antibody data, including each isotype individually as well as in combination, were assessed. Results: High pre-existing levels of anti-PEG antibodies increase the initial drug clearance. Analysed separately, both anti-PEG IgGprior and IgMprior were significant covariates; the stronger effect was observed for anti-PEG IgMprior. Hockey stick models best described the data. For anti-PEG IgMprior, each additional log unit above the estimated cut point was related to a 41.4% increase in initial clearance after the first dose in induction. Antibody levels below the cut point were not associated with an effect on clearance. The combination of both isotypes did not provide additional information compared to anti-PEG IgMprior alone. Antibody levels post administration were not associated with an effect on clearance. Conclusion: Pre-existing antibodies against PEG-ASNase significantly increased the initial clearance in a subgroup of patients showing high antibody levels. (Trial registration: EU clinical trials register; EudraCT No: 2007-004270-43; first registered 23 October 2009.)

Published
2022

18. Pre-existing antibodies against polyethylene glycol reduce asparaginase activities on first administration of pegylated E. coli asparaginase in children with acute lymphocytic leukemia

Author

Khalil, A, Wurthwein, G, Golitsch, J, Hempel, G, Fobker, M, Gerss, J, Moricke, A, Zimmermann, M, Smisek, P, Zucchetti, M, Nath, C, Attarbaschi, A, Von Stackelberg, A, Gokbuget, N, Rizzari, C, Conter, V, Schrappe, M, Boos, J, Lanvers-Kaminsky, C, Khalil A., Wurthwein G., Golitsch J., Hempel G., Fobker M., Gerss J., Moricke A., Zimmermann M., Smisek P., Zucchetti M., Nath C., Attarbaschi A., Von Stackelberg A., Gokbuget N., Rizzari C., Conter V., Schrappe M., Boos J., Lanvers-Kaminsky C., Khalil, A, Wurthwein, G, Golitsch, J, Hempel, G, Fobker, M, Gerss, J, Moricke, A, Zimmermann, M, Smisek, P, Zucchetti, M, Nath, C, Attarbaschi, A, Von Stackelberg, A, Gokbuget, N, Rizzari, C, Conter, V, Schrappe, M, Boos, J, Lanvers-Kaminsky, C, Khalil A., Wurthwein G., Golitsch J., Hempel G., Fobker M., Gerss J., Moricke A., Zimmermann M., Smisek P., Zucchetti M., Nath C., Attarbaschi A., Von Stackelberg A., Gokbuget N., Rizzari C., Conter V., Schrappe M., Boos J., and Lanvers-Kaminsky C.

Abstract

Antibodies against polyethylene glycol (PEG) in healthy subjects raise concerns about the efficacy of pegylated drugs. We evaluated the prevalence of antibodies against PEG among patients with acute lymphoblastic leukemia (ALL) prior to and/or immediately after their first dose of pegylated E.coli asparaginase (PEG-ASNase). Serum samples of 701 children, 673 with primary ALL, 28 with relapsed ALL, and 188 adults with primary ALL were analyzed for anti-PEG IgG and IgM. Measurements in 58 healthy infants served as reference to define cut-points for antibody-positive and -negative samples. Anti-PEG antibodies were detected in ALL patients prior the first PEG-ASNase with a prevalence of 13.9% (anti-PEG IgG) and 29.1% (anti-PEG IgM). After administration of PEG-ASNase the prevalence of anti-PEG antibodies decreased to 4.2% for anti-PEG IgG and to 4.5% for anti-PEG IgM. Pre-existing anti-PEG antibodies did not inhibit PEG-ASNase activity but significantly reduced PEGASNase activity levels in a concentration dependent manner. Although pre-existing anti-PEG antibodies did not boost, pre-existing anti-PEG IgG were significantly associated with firstexposure hypersensitivity reactions (CTCAE grade 2) (p.

Published
2022

23. Natural history of liver disease in a large international cohort of children with Alagille syndrome: Results from the GALA study

Author

Vandriel, SM, Li, L-T, She, H, Wang, J-S, Gilbert, MA, Jankowska, I, Czubkowski, P, Gliwicz-Miedzinska, D, Gonzales, EM, Jacquemin, E, Bouligand, J, Spinner, NB, Loomes, KM, Piccoli, DA, D'Antiga, L, Nicastro, E, Sokal, E, Demaret, T, Ebel, NH, Feinstein, JA, Fawaz, R, Nastasio, S, Lacaille, F, Debray, D, Arnell, H, Fischler, B, Siew, S, Stormon, M, Karpen, SJ, Romero, R, Kim, KM, Baek, WY, Hardikar, W, Shankar, S, Roberts, AJ, Evans, HM, Jensen, MK, Kavan, M, Sundaram, SS, Chaidez, A, Karthikeyan, P, Sanchez, MC, Cavalieri, ML, Verkade, HJ, Lee, WS, Squires, JE, Hajinicolaou, C, Lertudomphonwanit, C, Fischer, RT, Larson-Nath, C, Mozer-Glassberg, Y, Arikan, C, Lin, HC, Bernabeu, JQ, Alam, S, Kelly, DA, Carvalho, E, Ferreira, CT, Indolfi, G, Quiros-Tejeira, RE, Bulut, P, Calvo, PL, Onal, Z, Valentino, PL, Desai, DM, Eshun, J, Rogalidou, M, Dezsofi, A, Wiecek, S, Nebbia, G, Pinto, RB, Wolters, VM, Tamara, ML, Zizzo, AN, Garcia, J, Schwarz, K, Beretta, M, Sandahl, TD, Jimenez-Rivera, C, Kerkar, N, Brecelj, J, Mujawar, Q, Rock, N, Busoms, CM, Karnsakul, W, Lurz, E, Santos-Silva, E, Blondet, N, Bujanda, L, Shah, U, Thompson, RJ, Hansen, BE, Kamath, BM, Vandriel, SM, Li, L-T, She, H, Wang, J-S, Gilbert, MA, Jankowska, I, Czubkowski, P, Gliwicz-Miedzinska, D, Gonzales, EM, Jacquemin, E, Bouligand, J, Spinner, NB, Loomes, KM, Piccoli, DA, D'Antiga, L, Nicastro, E, Sokal, E, Demaret, T, Ebel, NH, Feinstein, JA, Fawaz, R, Nastasio, S, Lacaille, F, Debray, D, Arnell, H, Fischler, B, Siew, S, Stormon, M, Karpen, SJ, Romero, R, Kim, KM, Baek, WY, Hardikar, W, Shankar, S, Roberts, AJ, Evans, HM, Jensen, MK, Kavan, M, Sundaram, SS, Chaidez, A, Karthikeyan, P, Sanchez, MC, Cavalieri, ML, Verkade, HJ, Lee, WS, Squires, JE, Hajinicolaou, C, Lertudomphonwanit, C, Fischer, RT, Larson-Nath, C, Mozer-Glassberg, Y, Arikan, C, Lin, HC, Bernabeu, JQ, Alam, S, Kelly, DA, Carvalho, E, Ferreira, CT, Indolfi, G, Quiros-Tejeira, RE, Bulut, P, Calvo, PL, Onal, Z, Valentino, PL, Desai, DM, Eshun, J, Rogalidou, M, Dezsofi, A, Wiecek, S, Nebbia, G, Pinto, RB, Wolters, VM, Tamara, ML, Zizzo, AN, Garcia, J, Schwarz, K, Beretta, M, Sandahl, TD, Jimenez-Rivera, C, Kerkar, N, Brecelj, J, Mujawar, Q, Rock, N, Busoms, CM, Karnsakul, W, Lurz, E, Santos-Silva, E, Blondet, N, Bujanda, L, Shah, U, Thompson, RJ, Hansen, BE, and Kamath, BM

Abstract

BACKGROUND AND AIMS: Alagille syndrome (ALGS) is a multisystem disorder, characterized by cholestasis. Existing outcome data are largely derived from tertiary centers, and real-world data are lacking. This study aimed to elucidate the natural history of liver disease in a contemporary, international cohort of children with ALGS. APPROACH AND RESULTS: This was a multicenter retrospective study of children with a clinically and/or genetically confirmed ALGS diagnosis, born between January 1997 and August 2019. Native liver survival (NLS) and event-free survival rates were assessed. Cox models were constructed to identify early biochemical predictors of clinically evident portal hypertension (CEPH) and NLS. In total, 1433 children (57% male) from 67 centers in 29 countries were included. The 10 and 18-year NLS rates were 54.4% and 40.3%. By 10 and 18 years, 51.5% and 66.0% of children with ALGS experienced ≥1 adverse liver-related event (CEPH, transplant, or death). Children (>6 and ≤12 months) with median total bilirubin (TB) levels between ≥5.0 and <10.0 mg/dl had a 4.1-fold (95% confidence interval [CI], 1.6-10.8), and those ≥10.0 mg/dl had an 8.0-fold (95% CI, 3.4-18.4) increased risk of developing CEPH compared with those <5.0 mg/dl. Median TB levels between ≥5.0 and <10.0 mg/dl and >10.0 mg/dl were associated with a 4.8 (95% CI, 2.4-9.7) and 15.6 (95% CI, 8.7-28.2) increased risk of transplantation relative to <5.0 mg/dl. Median TB <5.0 mg/dl were associated with higher NLS rates relative to ≥5.0 mg/dl, with 79% reaching adulthood with native liver ( p < 0.001). CONCLUSIONS: In this large international cohort of ALGS, only 40.3% of children reach adulthood with their native liver. A TB <5.0 mg/dl between 6 and 12 months of age is associated with better hepatic outcomes. These thresholds provide clinicians with an objective tool to assist with clinical decision-making and in the evaluation of therapies.

Published
2023

24. Dynamic changes in prevalence of type 2 diabetes along with associated factors in Bangladesh : Evidence from two national cross-sectional surveys (BDHS 2011 and BDHS 2017–18)

Author

Shirin Sara, S., Talukder, A., Lee, Ka Yiu, Basak, N., Rahman Razu, S., Haq, I., Nath, C. D., Shirin Sara, S., Talukder, A., Lee, Ka Yiu, Basak, N., Rahman Razu, S., Haq, I., and Nath, C. D.

Abstract

Background and aims: Prevalence of type 2 diabetes has been rising rapidly especially in low- and middle-income countries. The purpose of this study is to analyze the prevalence of type 2 diabetes in 2011 and 2017–18, and the risk factors based on the Bangladesh Demographic and Health Surveys (BDHS). Methods: The study comprised of data from the BDHS 2011 and the BDHS 2017–18 with 7565 (50.6% female) and 12,299 respondents (56.9% female) respectively. The plasma blood glucose was classified into normal, pre-diabetes, and diabetes categories. While univariate analysis was performed to determine the data, Chi-square and gamma analyses were used for bivariate estimation of the correlation between diabetes status and other comorbidities. Multinomial and ordinal logistic regression were also performed to trace the link between diabetes and various risk factors. Results: The 2011 BDHS survey indicated that nearly half of the participants (47.6%) had pre-diabetic condition, while 10.2% were diagnosed with diabetes. On the other hand, the BDHS 2017-18 demonstrated that 28.6% and 8.6% of participants had pre-diabetes and diabetes, respectively. Results of inferential statistics showed that gender (p<0.05), age, wealth status, physical activity, BMI (p<0.01), and caffeinated beverages (p<0.05), were significantly linked with diabetes status. Conclusion: According to our findings, older people and people with lower education are more likely to develop diabetes. BMIˏ Physically active, wealth status, diet and lifestyle were significant predictors of type 2 diabetes. Healthy lifestyle, physical activities, proper knowledge and awareness can reduce the risk of T2D.

Published
2023
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26. Life History of Antheraea frithiMoore, (Lepidoptera: Saturniidae) on Terminalia arjuna(Roxb.) W&A Syn. in North Eastern Region of India

Author

Chutia, B., Nath, C., Goswami, L., Goswami, B., Gogoi, L., and Neog, K.

Abstract

Antheraea frithiMoore, the source of wild tasar silk, is an indigenous wild silk moth of north-east India. The detailed life history, bionomics and rearing performance of A. frithiin relation to a newly reported food plant, Terminalia arjuna(Roxb.) has been described in the present study. Life cycle of A. frithihas five larval instars. The first instar larva measures 1.98 ± 0.13 cm × 0.198 ± 0.010 cm in length and breadth and 0.0142 ± 0.002 g in weight while the fifth instar larva measures 6.98 ± 0.18 cm × 1.12 ± 0.13 cm in length and breadth and 4.76 ± 0.45 g in weight. Wing span of male and female is recorded as 11.4–13.5 and 13.0–14.7 cm respectively. The incubation period (6–7 days), larval duration (35–39 days), fecundity (162–176 eggs), hatching (78–81 %), effective rate of rearing (57–59 %) and cocoon yield (67–79 nos) has been recorded. The reelable cocoons with a filament length (mts) and filament denier (d) is 493–575 m and 4.6–5.3 respectively. The shell weight (g) of male and female cocoons measures as 0.19–0.39 and 0.2–0.6, respectively. The shell ratio (%) for male and female cocoons stands as 8.1–8.4 and 9.4–9.8 % respectively.

Published
2024
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28. Weed seedbank, above‐ground weed community and crop yields under conventional and conservation agriculture practices in maize–wheat–mungbean rotation.

Author

Ghosh, Sonaka, Das, T. K., Nath, C. P., Bhatia, Arti, Biswas, D. R., Bandyopadhyay, K. K., Yeasin, Md, and Raj, Rishi

Subjects
WEEDS, CROP yields, CROP rotation, MUNG bean, SUSTAINABILITY, CROP residues, YELLOW nutsedge, NUTGRASS
Abstract

Weeds are the major biological barriers to achieving higher yields in agro‐ecosystem. We aimed to determine weed community (seedbank and aboveground) and crop yield responses to conventional tillage (CT) and different types of conservation agriculture (CA) practices with variable nitrogen (N) doses in a maize (Zea mays L.)–wheat (Triticum aestivum L.)–mungbean (Vigna radiata L.) rotation. After 8 years of implementation, CA practices including zero‐tilled (ZT) permanent narrow‐bed with crop residues and 100% required N (PNB + R + 100 N), and ZT permanent broad‐bed with residues and 100% required N (PBB + R + 100 N) had a lower weed seed density by 45% at 0–7.5 cm and 53% at 7.5–15 cm soil layers than CT. CT promoted dominance of Cyperus rotundus L., Cyperus esculentus L. and Dinebra retroflexa (Vahl) Panz. while, specific CA practices (PNB + R + 100 N and PBB + R + 100 N) promoted dominance of Digera arvensis Forsk. and Melilotus indicus (L.). Compared to PNB + R + 100 N and PBB + R + 100 N, CT seedbanks had 41–46% higher ecological dominance, which is an indicator that delineates dominance of few specific weed species. The PBB + R + 100 N also had a lower total above‐ground weed density in maize–wheat–mungbean rotation by 34% (mean of years) than CT. The PBB + R + 100 N had 31.1% higher system productivity over CT. Thus, PBB + R + 100 N could reduce the weed seed density in the soil and above‐ground weeds and increase crop yields for sustainable crop production in maize–wheat–mungbean rotations. [ABSTRACT FROM AUTHOR]

Published
2023
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30. Natural history of liver disease in a large international cohort of children with Alagille syndrome: results from The GALA Study

Author

Arıkan, Çiğdem (ORCID 0000-0002-0794-2741 & YÖK ID 240198), Vandriel, S.M.; Li, L.T.; She, H.; Wang, J.S.; Gilbert, M.A.; Jankowska, I.; Czubkowski, P.; Gliwicz-Miedzi?ska, D.; Gonzales, E.M.; Jacquemin, E.; Bouligand, J.; Spinner, N.B.; Loomes, K.M.; Piccoli, D.A.; D'Antiga, L.; Nicastro, E.; Sokal, É.; Demaret, T.; Ebel, N.H.; Feinstein, J.A.; Fawaz, R.; Nastasio, S.; Lacaille, F.; Debray, D.; Arnell, H.; Fischler, B.; Siew, S.; Stormon, M.; Karpen, S.J.; Romero, R.; Kim, K.M.; Baek, W.Y.; Hardikar, W.; Shankar, S.; Roberts, A.J.; Evans, H.M.; Jensen, M.K.; Kavan, M.; Sundaram, S.S.; Chaidez, A.; Karthikeyan, P.; Sanchez, M.C.; Cavalieri, M.L.; Verkade, H.J.; Lee, W.S.; Squires, J.E.; Hajinicolaou, C.; Lertudomphonwanit, C.; Fischer, R.T.; Larson-Nath, C.; Mozer-Glassberg, Y.; Lin, H.C.; Quintero, Bernabeu J.; Alam, S.; Kelly, D.; Carvalho, E.; Ferreira, C.T.; Indolfi, G.; Quiros-Tejeira, R.E.; Bulut, P.; Calvo, P.L.; Önal, Z.; Valentino, P.L.; Desai, D.M.; Eshun, J.; Rogalidou, M.; Dezs?fi, A.; Wiecek, S.; Nebbia, G.; Borges Pinto, R.; Wolters, V.M.; Tamara, M.L.; Zizzo, A.N.; Garcia, J.; Schwarz, K.; Beretta, M.; Sandahl, T.D.; Jimenez-Rivera, C.; Kerkar, N.; Brecelj, J.; Mujawar, Q.; Rock, N.; Busoms, C.M.; Karnsakul, W.; Lurz, E.; Santos-Silva, E.; Blondet, N.; Bujanda, L.; Shah, U.; Thompson, R.J.; Hansen, B.E.; Kamath, B.M.; Global ALagille Alliance (GALA) Study Group, Koç University Hospital, School of Medicine, Arıkan, Çiğdem (ORCID 0000-0002-0794-2741 & YÖK ID 240198), Vandriel, S.M.; Li, L.T.; She, H.; Wang, J.S.; Gilbert, M.A.; Jankowska, I.; Czubkowski, P.; Gliwicz-Miedzi?ska, D.; Gonzales, E.M.; Jacquemin, E.; Bouligand, J.; Spinner, N.B.; Loomes, K.M.; Piccoli, D.A.; D'Antiga, L.; Nicastro, E.; Sokal, É.; Demaret, T.; Ebel, N.H.; Feinstein, J.A.; Fawaz, R.; Nastasio, S.; Lacaille, F.; Debray, D.; Arnell, H.; Fischler, B.; Siew, S.; Stormon, M.; Karpen, S.J.; Romero, R.; Kim, K.M.; Baek, W.Y.; Hardikar, W.; Shankar, S.; Roberts, A.J.; Evans, H.M.; Jensen, M.K.; Kavan, M.; Sundaram, S.S.; Chaidez, A.; Karthikeyan, P.; Sanchez, M.C.; Cavalieri, M.L.; Verkade, H.J.; Lee, W.S.; Squires, J.E.; Hajinicolaou, C.; Lertudomphonwanit, C.; Fischer, R.T.; Larson-Nath, C.; Mozer-Glassberg, Y.; Lin, H.C.; Quintero, Bernabeu J.; Alam, S.; Kelly, D.; Carvalho, E.; Ferreira, C.T.; Indolfi, G.; Quiros-Tejeira, R.E.; Bulut, P.; Calvo, P.L.; Önal, Z.; Valentino, P.L.; Desai, D.M.; Eshun, J.; Rogalidou, M.; Dezs?fi, A.; Wiecek, S.; Nebbia, G.; Borges Pinto, R.; Wolters, V.M.; Tamara, M.L.; Zizzo, A.N.; Garcia, J.; Schwarz, K.; Beretta, M.; Sandahl, T.D.; Jimenez-Rivera, C.; Kerkar, N.; Brecelj, J.; Mujawar, Q.; Rock, N.; Busoms, C.M.; Karnsakul, W.; Lurz, E.; Santos-Silva, E.; Blondet, N.; Bujanda, L.; Shah, U.; Thompson, R.J.; Hansen, B.E.; Kamath, B.M.; Global ALagille Alliance (GALA) Study Group, Koç University Hospital, and School of Medicine

Abstract

Background and aims: Alagille syndrome (ALGS) is a multisystem disorder, characterized by cholestasis. Existing outcome data are largely derived from tertiary centers, and real-world data are lacking. This study aimed to elucidate the natural history of liver disease in a contemporary, international cohort of children with ALGS. Approach and results: This was a multicenter retrospective study of children with a clinically and/or genetically confirmed ALGS diagnosis, born between January 1997 and August 2019. Native liver survival (NLS) and event-free survival rates were assessed. Cox models were constructed to identify early biochemical predictors of clinically evident portal hypertension (CEPH) and NLS. In total, 1433 children (57% male) from 67 centers in 29 countries were included. The 10 and 18-year NLS rates were 54.4% and 40.3%. By 10 and 18 years, 51.5% and 66.0% of children with ALGS experienced >= 1 adverse liver-related event (CEPH, transplant, or death). Children (>6 and <= 12 months) with median total bilirubin (TB) levels between >= 5.0 and <10.0 mg/dl had a 4.1-fold (95% confidence interval [CI], 1.6-10.8), and those >= 10.0 mg/dl had an 8.0-fold (95% CI, 3.4-18.4) increased risk of developing CEPH compared with those 10.0 mg/dl were associated with a 4.8 (95% CI, 2.4-9.7) and 15.6 (95% CI, 8.7-28.2) increased risk of transplantation relative to <5.0 mg/dl. Median TB <5.0 mg/dl were associated with higher NLS rates relative to >= 5.0 mg/dl, with 79% reaching adulthood with native liver (p < 0.001). Conclusions: in this large international cohort of ALGS, only 40.3% of children reach adulthood with their native liver. A TB <5.0 mg/dl between 6 and 12 months of age is associated with better hepatic outcomes. These thresholds provide clinicians with an objective tool to assist with clinical decision-making and in the evaluation of therapies., This study received funding support from the following agencies: The Alagille Syndrome Alliance, Mirum Pharmaceuticals Inc. and Albireo Pharma, Inc. who provided unrestricted educational grants to the Hospital for Sick Children (SickKids Foundation). The study sponsors were not involved in the conduct of the research study or preparation of the manuscript.

Published
2022

38. Association study of candidate DNA-repair gene variants and acute graft versus host disease in pediatric patients receiving allogeneic hematopoietic stem-cell transplantation

Author

Uppugunduri, C. R. S., primary, Huezo-Diaz Curtis, P., additional, Nava, T., additional, Rezgui, M. A., additional, Mlakar, V., additional, Mlakar, S. Jurkovic, additional, Waespe, N., additional, Théoret, Y., additional, Gumy-Pause, F., additional, Bernard, F., additional, Chalandon, Y., additional, Boelens, J. J., additional, Bredius, R. G. M., additional, Dalle, J. H., additional, Nath, C., additional, Corbacioglu, S., additional, Peters, C., additional, Bader, P., additional, Shaw, P., additional, Bittencourt, H., additional, Krajinovic, M., additional, and Ansari, M., additional

Published
2021
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43. Therapeutic Drug Monitoring of Asparaginase: Intra-individual Variability and Predictivity in Children With Acute Lymphoblastic Leukemia Treated With PEG-Asparaginase in the AIEOP-BFM Acute Lymphoblastic Leukemia 2009 Study

Author

Würthwein, G, Lanverskaminsky, C, Gerss, J, Möricke, A, Zimmermann, M, Stary, J, Smisek, P, Attarbaschi, A, Nath, C, Zucchetti, M, Rizzari, C, Schrappe, M, Boos, J, LanversKaminsky, C, Stary, Jan, Würthwein, G, Lanverskaminsky, C, Gerss, J, Möricke, A, Zimmermann, M, Stary, J, Smisek, P, Attarbaschi, A, Nath, C, Zucchetti, M, Rizzari, C, Schrappe, M, Boos, J, LanversKaminsky, C, and Stary, Jan

Abstract

BACKGROUND: Therapeutic drug monitoring (TDM) can identify patients with subtherapeutic asparaginase (ASNase) activity [silent inactivation (SI)] and prospectively guide therapeutic adaptation. However, limited intra-individual variability is a precondition for targeted dosing and the diagnosis of SI. METHODS: In the AIEOP-BFM acute lymphoblastic leukemia (ALL) 2009 trial, 2771 children with ALL were included and underwent ASNase-TDM in a central laboratory in Münster. Two biweekly administrations of pegylated ASNase during induction and a third dose during reinduction or the high-risk block, which was administered several weeks later, were monitored. We calculated (1) the incidence of SI; and (2) the predictivity of SI for SI after the subsequent administration. ASNase activities monitored during induction were categorized into percentiles at the respective sampling time points. These percentiles were used to calculate the intra-individual range of percentiles as a surrogate for intrapatient variability and to evaluate the predictivity of ASNase activity for the subsequent administration. RESULTS: The overall incidence of SI was low (4.9%). The positive predictive value of SI identified by one sample was ≤21%. Confirmation of SI by a second sample indicated a high positive predictive value of 100% for biweekly administrations, but not for administration more than 17 weeks later. Sampling and/or documentation errors were risks for misdiagnosis of SI. High intra-individual variability in ASNase activities, with ranges of percentiles over more than 2 quartiles and low predictivity, was observed in approximately 25% of the patients. These patients were likely to fail dose individualization based on TDM data. CONCLUSIONS: To use TDM as a basis for clinical decisions, standardized clinical procedures are required and high intra-individual variability should be taken into account. Details of the treatment are available in the European Clinical Trials Database at https

Published
2020

44. Rutford Ice Stream, Antarctica

Author

Doake, C. S. M., primary, Corr, H. F. J., additional, Jenkins, A., additional, Makinson, K., additional, Nicholls, K. W., additional, Nath, C., additional, Smith, A. M., additional, and Vaughan, D. G., additional

Published
2013
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46. Diffractive dijet cross sections in photoproduction at HERA

Author

Breitweg, J., Derrick, M., Krakauer, D., Magill, S., Mikunas, D., Musgrave, B., Repond, J., Stanek, R., Talaga, R. L., Yoshida, R., Zhang, H., Mattingly, M. C. K., Anselmo, F., Antonioli, P., Bari, G., Basile, M., Bellagamba, L., Boscherini, D., Bruni, A., Bruni, G., Romeo, G. Cara, Castellini, G., Cifarelli, L., Cindolo, F., Contin, A., Coppola, N., Corradi, M., De Pasquale, S., Giusti, P., Iacobucci, G., Laurenti, G., Levi, G., Margotti, A., Massam, T., Nania, R., Palmonari, F., Pesci, A., Polini, A., Sartorelli, G., Garcia, Y. Zamora, Zichichi, A., Amelung, C., Bornheim, A., Brock, I., Coböken, K., Crittenden, J., Deffner, R., Eckert, M., Grothe, M., Hartmann, H., Heinloth, K., Heinz, L., Hilger, E., Jakob, H. -P., Kappes, A., Katz, U. F., Kerger, R., Paul, E., Pfeiffer, M., Stamm, J., Wieber, H., Bailey, D. S., Campbell-Robson, S., Cottingham, W. N., Foster, B., Hall-Wilton, R., Heath, G. P., Heath, H. F., McFall, J. D., Piccioni, D., Roff, D. G., Tapper, R. J., Ayad, R., Capua, M., Iannotti, L., Schioppa, M., Susinno, G., Kim, J. Y., Lee, J. H., Lim, I. T., Pac, M. Y., Caldwell, A., Cartiglia, N., Jing, Z., Liu, W., Mellado, B., Parsons, J. A., Ritz, S., Sampson, S., Sciulli, F., Straub, P. B., Zhu, Q., Borzemski, P., Chwastowski, J., Eskreys, A., Figiel, J., Klimek, K., Przybycień, M. B., Zawiejski, L., Adamczyk, L., Bednarek, B., Bukowy, M., Czermak, A. M., Jeleń, K., Kisielewska, D., Kowalski, T., Przybycień, M., Rulikowska-Zarbska, E., Suszycki, L., Zajc, J., Duliński, Z., Kotański, A., Abbiendi, G., Bauerdick, L. A. T., Behrens, U., Beier, H., Bienlein, J. K., Desler, K., Drews, G., Fricke, U., Gialas, I., Goebel, F., Göttlicher, P., Graciani, R., Haas, T., Hain, W., Hasell, D., Hebbel, K., Johnson, K. F., Kasemann, M., Koch, W., Kötz, U., Kowalski, H., Lindemann, L., Löhr, B., Milewski, J., Milite, M., Monteiro, T., Ng, J. S. T., Notz, D., Park, I. H., Pellegrino, A., Pelucchi, F., Piotrzkowski, K., Rohde, M., Roldán, J., Ryan, J. J., Savin, A. A., Schneekloth, U., Schwarzer, O., Selonke, F., Stonjek, S., Surrow, B., Tassi, E., Westphal, D., Wolf, G., Wollmer, U., Youngman, C., Zeuner, W., Burow, B. D., Coldewey, C., Grabosch, H. J., Meyer, A., Schlenstedt, S., Barbagli, G., Gallo, E., Pelfer, P., Maccarrone, G., Votano, L., Bamberger, A., Eisenhardt, S., Markun, P., Raach, H., Trefzger, T., Wölfle, S., Bromley, J. T., Brook, N. H., Bussey, P. J., Doyle, A. T., Macdonald, N., Saxon, D. H., Sinclair, L. E., Skillicorn, I. O., Strickland, E., Waugh, R., Bohnet, I., Gendner, N., Holm, U., Meyer-Larsen, A., Salehi, H., Wick, K., Garfagnini, A., Gladilin, L. K., Horstmann, D., Kçira, D., Klanner, R., Lohrmann, E., Poelz, G., Schott, W., Zetsche, F., Bacon, T. C., Butterworth, I., Cole, J. E., Howell, G., Lamberti, L., Long, K. R., Miller, D. B., Pavel, N., Prinias, A., Sedgbeer, J. K., Sideris, D., Walker, R., Mallik, U., Wang, S. M., Wu, J. T., Cloth, P., Filges, D., Fleck, J. I., Ishii, T., Kuze, M., Suzuki, I., Tokushuku, K., Yamada, S., Yamauchi, K., Yamazaki, Y., Hong, S. J., Lee, S. B., Nam, S. W., Park, S. K., Barreiro, F., Fernández, J. P., García, G., Glasman, C., Hernández, J. M., Hervás, L., Labarga, L., Martínez, M., Peso, J. del, Puga, J., Terrón, J., Trocóniz, J. F. de, Corriveau, F., Hanna, D. S., Hartmann, J., Hung, L. W., Murray, W. N., Ochs, A., Riveline, M., Stairs, D. G., St-Laurent, M., Ullmann, R., Tsurugai, T., Bashkirov, V., Dolgoshein, B. A., Stifutkin, A., Bashindzhagyan, G. L., Ermolov, P. F., Golubkov, Yu. A., Khein, L. A., Korotkova, N. A., Korzhavina, I. A., Kuzinin, V. A., Lukina, O. Yu., Proskuryakov, A. S., Shcheglova, L. M., Solomin, A. N., Zotkin, S. A., Bokel, C., Botje, M., Brümmer, N., Engelen, J., Koffeman, E., Kooijman, P., van Sighem, A., Tiecke, H., Tuning, N., Verkerke, W., Vossebeld, J., Wiggers, L., Wolf, E. de, Acosta, D., Bylsma, B., Durkin, L. S., Gilmore, J., Ginsburg, C. M., Kim, C. L., Ling, T. Y., Nylander, P., Romanowski, T. A., Blaikley, H. E., Cashmore, R. J., Cooper-Sarkar, A. M., Devenish, R. C. E., Edmonds, J. K., Große-Knetter, J., Harnew, N., Nath, C., Noyes, V. A., Quadt, A., Ruske, O., Tickner, J. R., Walczak, R., Waters, D. S., Bertolin, A., Brugnera, R., Carlin, R., Corso, F. Dal, Dosselli, U., Limentani, S., Morandin, M., Posocco, M., Stanco, L., Stroili, R., Voci, C., Bulmahn, J., Oh, B. Y., Okrasiński, J. R., Toothacker, W. S., Whitmore, J. J., Iga, Y., D’Agostini, G., Marini, G., Nigro, A., Raso, M., Hart, J. C., McCubbin, N. A., Shah, T. P., Epperson, D., Heusch, C., Rahn, J. T., Sadrozinski, H. F. -W., Seiden, A., Wichmann, R., Williams, D. C., Abramowicz, H., Briskin, G., Dagan, S., Kananov, S., Levy, A., Abe, T., Fusayasu, T., Inuzuka, M., Nagano, K., Umemori, K., Yamashita, T., Hamatsu, R., Hirose, T., Homma, K., Kitamura, S., Matsushita, T., Arneodo, M., Cirio, R., Costa, M., Ferrero, M. I., Maselli, S., Monaco, V., Peroni, C., Petrucci, M. C., Ruspa, M., Sacchi, R., Solano, A., Staiano, A., Dardo, M., Bailey, D. C., Fagerstroem, C. -P., Galea, R., Hartner, G. F., Joo, K. K., Levman, G. M., Martin, J. F., Orr, R. S., Polenz, S., Sabetfakhri, A., Simmons, D., Teuscher, R. J., Butterworth, J. M., Catterall, C. D., Hayes, M. E., Jones, T. W., Lane, J. B., Saunders, R. L., Sutton, M. R., Wing, M., Ciborowski, J., Grzelak, G., Kasprzak, M., Nowak, R. J., Pawlak, J. M., Pawlak, R., Tymieniecka, T., Wróblewski, A. K., Zakrzewski, J. A., Zarnecki, A. F., Adamus, M., Deppe, O., Eisenberg, Y., Hochman, D., Karshon, U., Badgett, W. F., Chapin, D., Cross, R., Dasu, S., Foudas, C., Loveless, R. J., Mattingly, S., Reeder, D. D., Smith, W. H., Vaiciulis, A., Wodarczyk, M., Deshpande, A., Dhawan, S., Hughes, V. W., Bhadra, S., Frisken, W. R., Khakzad, M., and Schmidke, W. B.

Published
1998
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47. Measurement of the diffractive structure functionF 2 D(4) at HERA

Author

Breitweg, J., Derrick, M., Krakauer, D., Magill, S., Mikunas, D., Musgrave, B., Repond, J., Stanek, R., Talaga, R. L., Yoshida, R., Zhang, H., Mattingly, M. C. K., Anselmo, F., Antonioli, P., Bari, G., Basile, M., Bellagamba, L., Boscherini, D., Bruni, A., Bruni, G., Romeo, G. Cara, Castellini, G., Chiarini, M., Cifarelli, L., Cindolo, F., Contin, A., Corradi, M., De Pasquale, S., Gialas, I., Giusti, P., Iacobucci, G., Laurenti, G., Levi, G., Margotti, A., Massam, T., Nania, R., Nemoz, C., Palmonari, F., Pesci, A., Polini, A., Ricci, F., Sartorelli, G., Zamora Garcia, Y., Zichichi, A., Amelung, C., Bornheim, A., Brock, I., Coböken, K., Crittenden, J., Deffner, R., Eckert, M., Grothe, M., Hartmann, H., Heinloth, K., Heinz, L., Hilger, E., Jakob, H. -P., Katz, U. F., Kerger, R., Paul, E., Pfeiffer, M., Rembser, Ch., Stamm, J., Wedemeyer, R., Wieber, H., Bailey, D. S., Campbell-Robson, S., Cottingham, W. N., Foster, B., Hall-Wilton, R., Hayes, M. E., Heath, G. P., Heath, H. F., McFall, J. D., Piccioni, D., Roff, D. G., Tapper, R. J., Arneodo, M., Ayad, R., Capua, M., Garfagnini, A., Iannotti, L., Schioppa, M., Susinno, G., Kim, J. Y., Lee, J. H., Lim, L. T., Pac, M. Y., Caldwell, A., Cartiglia, N., Jing, Z., Liu, W., Mellado, B., Parsons, J. A., Ritz, S., Sampson, S., Sciulli, F., Straub, P. B., Zhu, Q., Borzemski, P., Chwastowski, J., Eskreys, A., Figiel, J., Klimek, K., Przybycień, M. B., Zawiejski, L., Adamczyk, L., Bednarek, B., Bukowy, M., Jeleń, K., Kisielewska, D., Kowalski, T., Przybycień, M., Rulikowska-Zareebska, E., Suszycki, L., Zajac, J., Duliński, Z., Kotański, A., Abbiendi, G., Bauerdick, L. A. T., Behrens, U., Beier, H., Bienlein, J. K., Cases, G., Deppe, O., Desler, K., Drews, G., Fricke, U., Gilkinson, D. J., Glasman, C., Göttlicher, P., Haas, T., Hain, W., Hasell, D., Johnson, K. F., Kasemann, M., Koch, W., Kötz, U., Kowalski, H., Labs, J., Lindemann, L., Löhr, B., Löwe, M., Mańczak, O., Milewski, J., Monteiro, T., Ng, J. S. T., Notz, D., Ohrenberg, K., Park, I. H., Pellegrino, A., Pelucchi, F., Piotrzkowski, K., Roco, M., Rohde, M., Roldán, J., Ryan, J. J., Savin, A. A., Schneekloth, U., Selonke, F., Surrow, B., Tassi, E., Voß, T., Westphal, D., Wolf, G., Wollmer, U., Youngman, C., Zarnecki, A. F., Zeuner, W., Burow, B. D., Grabosch, H. J., Meyer, A., Schlenstedt, S., Barbagli, G., Gallo, E., Pelfer, P., Anzivino, G., Maccarrone, G., Votano, L., Barberger, A., Eisenhardt, S., Markun, P., Trefzger, T., Wölfle, S., Bromley, J. T., Brook, N. H., Bussey, P. J., Doyle, A. T., Macdonald, N., Saxon, D. H., Sinclair, L. E., Strickland, E., Waugh, R., Bohnet, I., Gendner, N., Holm, U., Meyer-Larsen, A., Salchi, H., Wick, K., Gladilin, L. K., Horstmann, D., Kçira, D., Klanner, R., Lohrmann, E., Poelz, G., Schott, W., Bacon, T. C., Butterworth, I., Cole, J. E., Howell, G., Hung, B. H. Y., Lamberti, L., Long, K. R., Prinias, A., Sedgbeer, J. K., Sideris, D., Mallik, U., Wang, S. M., Wu, J. T., Cloth, P., Filges, D., Fleck, J. I., Ishii, T., Kuze, M., Suzuki, I., Tokushuku, K., Yamada, S., Yamauchi, K., Yamazaki, Y., Hong, S. J., Lee, S. B., Nam, S. W., Park, S. K., Barreiro, F., Fernández, J. P., García, G., Graciani, R., Hernández, J. M., Hervás, L., Labarga, L., Martínez, M., del Peso, J., Puga, J., Terrón, J., de Trocóniz, J. F., Corriveau, F., Hanna, D. S., Hartmann, J., Hung, L. W., Murray, N., Ochs, A., Riveline, M., Stairs, D. G., St-Laurent, M., Ullmann, R., Tsurugai, T., Bashkirov, V., Dolgoshein, B. A., Stifutkin, A., Bashindzhagyan, G. L., Ermolov, P. F., Golubkov, Yu. A., Khein, L. A., Korotkova, N. A., Korzhavina, I. A., Kuzmin, V. A., Lukina, O. Yu., Proskuryakov, A. S., Shcheglova, L. M., Solomin, A. N., Zotkin, S. A., Bokel, C., Botje, M., Brummer, N., Chlebana, F., Engelen, J., Koffeman, E., Kooijman, P., van Sighem, A., Tiecke, H., Tuning, N., Verkerke, W., Vossebeld, J., Vreeswijk, M., Wiggers, L., de Wolf, E., Acosta, D., Bylsma, B., Durkin, L. S., Gilmore, J., Ginsburg, C. M., Kim, C. L., Ling, T. Y., Nylander, P., Romanowski, T. A., Blaikley, H. E., Cashmore, R. J., Cooper-Sarkar, A. M., Devenish, R. C. E., Edmonds, J. K., Große-Knetter, J., Harnew, N., Lancaster, M., Nath, C., Noyes, V. A., Quadt, A., Ruske, O., Tickner, J. R., Uijterwaal, H., Walczak, R., Waters, D. S., Bertolin, A., Bruguera, R., Carlin, R., Dal Corso, F., Dosselli, U., Limentani, S., Morandin, M., Posocco, M., Stanco, L., Stroili, R., Voci, C., Bulmahn, J., Oh, B. Y., Okrasinski, J. R., Toothacker, W. S., Whitmore, J. J., Iga, Y., D'Agostini, G., Marini, G., Nigro, A., Raso, M., Hart, J. C., McCubbin, N. A., Shah, T. P., Barberis, E., Epperson, D., Heusch, C., Rahn, J. T., Sadrozinski, H. F. -W., Seiden, A., Wichmann, R., Williams, D. C., Schwarzer, O., Walenta, A. H., Abramowicz, H., Briskin, G., Dagan, S., Kananov, S., Levy, A., Abe, T., Fusayasu, T., Inuzuka, M., Nagano, K., Umemori, K., Yamashita, T., Hamatsu, R., Hirose, T., Homma, K., Kitamura, S., Matsushita, T., Cirio, R., Costa, M., Ferrero, M. I., Maselli, S., Monaco, V., Peroni, C., Petrucci, M. C., Ruspa, M., Sacchi, R., Solano, A., Staiano, A., Dardo, M., Bailey, D. C., Fagerstroem, C. -P., Galea, R., Hartner, G. F., Joo, K. K., Levman, G. M., Martin, J. F., Orr, R. S., Polenz, S., Sabetfakhri, A., Simmons, D., Teuscher, R. J., Butterworth, J. M., Catterall, C. D., Jones, T. W., Lane, J. B., Saunders, R. L., Shulman, J., Sutton, M. R., Wing, M., Ciborowski, J., Grzelak, G., Kasprzak, M., Muchorowski, K., Nowak, R. J., Pawlak, J. M., Pawlak, R., Tymieniecka, T., Wróblewski, A. K., Zakrzewski, J. A., Adamus, M., Coldewey, C., Eisenberg, Y., Hochman, D., Karshon, U., Badgett, W. F., Chapin, D., Cross, R., Dasu, S., Foudas, C., Loveless, R. J., Mattingly, S., Reeder, D. D., Smith, W. H., Vaiciulis, A., Wodarczyk, M., Bhadra, S., Frisken, W. R., Khakzad, M., Schmidke, W. B., and ZEUS Collaboration

Published
1998
Full Text
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50. Comparison of ZEUS data with standard model predictions for e+p → e+X scattering at high x and Q2

Author

Breitweg, J., Derrick, M., Krakauer, D., Magill, S., Mikunas, D., Musgrave, B., Repond, J., Stanek, R., Talaga, R. L., Yoshida, R., Zhang, H., Mattingly, M. C. K., Anselmo, F., Antonioli, P., Bari, G., Basile, M., Bellagamba, L., Boscherini, D., Bruni, A., Bruni, G., Romeo, G. Cara, Castellini, G., Cifarelli, L., Cindolo, F., Contin, A., Corradi, M., De Pasquale, S., Gialas, I., Giusti, P., Iacobucci, G., Laurenti, G., Levi, G., Margotti, A., Massam, T., Nania, R., Palmonari, F., Pesci, A., Polini, A., Sartorelli, G., Garcia, Y. Zamora, Zichichi, A., Amelung, C., Bornheim, A., Brock, I., Coböken, K., Crittenden, J., Deffner, R., Eckert, M., Feld, L., Grothe, M., Hartmann, H., Heinloth, K., Heinz, L., Hilger, E., Jakob, H. P., Katz, U. F., Paul, E., Pfeiffer, M., Rembser, Ch., Stamm, J., Wedemeyer, R., Bailey, D. S., Campbell-Robson, S., Cottingham, W. N., Foster, B., Hall-Wilton, R., Hayes, M. E., Heath, G. P., Heath, H. F., Piccioni, D., Roff, D. G., Tapper, R. J., Arneodo, M., Ayad, R., Capua, M., Garfagnini, A., Iannotti, L., Schioppa, M., Susinno, G., Kim, J. Y., Lee, J. H., Lim, I. T., Pac, M. Y., Caldwell, A., Cartiglia, N., Jing, Z., Liu, W., Parsons, J. A., Ritz, S., Sampson, S., Sciulli, F., Straub, P. B., Zhu, Q., Borzemski, P., Chwastowski, J., Eskreys, A., Jakubowski, Z., Przybycień, M. B., Zachara, M., Zawiejski, L., Adamczyk, L., Bednarek, B., Jeleń, K., Kisielewska, D., Kowalski, T., Przybycień, M., Rulikowska-Zare̹bska, E., Suszycki, L., Zaja̹c, J., Duliński, Z., Kotański, A., Abbiendi, G., Bauerdick, L. A. T., Behrens, U., Beier, H., Bienlein, J. K., Cases, G., Deppe, O., Desler, K., Drews, G., Gilkinson, D. J., Glasman, C., Göttlicher, P., Große-Knetter, J., Haas, T., Hain, W., Hasell, D., Heßling, H., Iga, Y., Johnson, K. F., Kasemann, M., Koch, W., Kötz, U., Kowalski, H., Labs, J., Lindemann, L., Löhr, B., Löwe, M., Mainusch, J., Mańczak, O., Milewski, J., Monteiro, T., Ng, J. S. T., Notz, D., Ohrenberg, K., Park, I. H., Pellegrino, A., Pelucchi, F., Piotrzkowski, K., Roco, M., Rohde, M., Roldán, J., Savin, A. A., Schneekloth, U., Schulz, W., Selonke, F., Surrow, B., Tassi, E., Voß, T., Westphal, D., Wolf, G., Wollmer, U., Youngman, C., Żarnecki, A. F., Zeuner, W., Burow, B. D., Grabosch, H. J., Meyer, A., Schlenstedt, S., Barbagli, G., Gallo, E., Pelfer, P., Maccarrone, G., Votano, L., Bamberger, A., Eisenhardt, S., Markun, P., Trefzger, T., Wölfle, S., Bromley, J. T., Brook, N. H., Bussey, P. J., Doyle, A. T., Saxon, D. H., Sinclair, L. E., Strickland, E., Utley, M. L., Waugh, R., Wilson, A. S., Bohnet, I., Gendner, N., Holm, U., Meyer-Larsen, A., Salehi, H., Wick, K., Gladilin, L. K., Klanner, R., Lohrmann, E., Poelz, G., Schott, W., Zetsche, F., Bacon, T. C., Butterworth, I., Cole, J. E., Harris, V. L., Howell, G., Hung, B. H. Y., Lamberti, L., Long, K. R., Miller, D. B., Pavel, N., Prinias, A., Sedgbeer, J. K., Sideris, D., Whitfield, A. F., Mallik, U., Wang, S. M., Wu, J. T., Cloth, P., Filges, D., An, S. H., Lee, S. B., Nam, S. W., Park, H. S., Park, S. K., Barreiro, F., Fernandez, J. P., Graciani, R., Hernández, J. M., Hervás, L., Labarga, L., Martinez, M., del Peso, J., Puga, J., Terron, J., de Trocóniz, J. F., Corriveau, F., Hanna, D. S., Hartmann, J., Hung, L. W., Lim, J. N., Murray, W. N., Ochs, A., Riveline, M., Stairs, D. G., St-Laurent, M., Ullmann, R., Tsurugai, T., Bashkirov, V., Dolgoshein, B. A., Stifutkin, A., Bashindzhagyan, G. L., Ermolov, P. F., Golubkov, Yu. A., Kobrin, V. D., Korzhavina, I. A., Kuzmin, V. A., Lukina, O. Yu., Proskuryakov, A. S., Shcheglova, L. M., Solomin, A. N., Zotov, N. P., Bokel, C., Botje, M., Brümmer, N., Chlebana, F., Engelen, J., de Kamps, M., Kooijman, P., Kruse, A., van Sighem, A., Tiecke, H., Verkerke, W., Vossebeld, J., Vreeswijk, M., Wiggers, L., de Wolf, E., Acosta, D., Bylsma, B., Durkin, L. S., Gilmore, J., Ginsburg, C. M., Kim, C. L., Ling, T. Y., Nylander, P., Romanowski, T. A., Blaikley, H. E., Cashmore, R. J., Cooper-Sarkar, A. M., Devenish, R. C. E., Edmonds, J. K., Harnew, N., Lancaster, M., McFall, J. D., Nath, C., Noyes, V. A., Quadt, A., Tickner, J. R., Uijterwaal, H., Walczak, R., Waters, D. S., Yip, T., Bertolin, A., Brugnera, R., Carlin, R., Dal Corso, F., Dosselli, U., Limentani, S., Morandin, M., Posocco, M., Stanco, L., Stroili, R., Voci, C., Bulmahn, J., Feild, R. G., Oh, B. Y., Okrasiński, J. R., Whitmore, J. J., Marini, G., Nigro, A., Hart, J. C., McCubbin, N. A., Shah, T. P., Barberis, E., Dubbs, T., Heusch, C., Van Hook, M., Lockman, W., Rahn, J. T., Sadrozinski, H. F. W., Seiden, A., Williams, D. C., Schwarzer, O., Walenta, A. H., Abramowicz, H., Briskin, G., Dagan, S., Doeker, T., Kananov, S., Levy, A., Abe, T., Fleck, J. I., Inuzuka, M., Ishii, T., Kuze, M., Nagano, K., Nakao, M., Suzuki, I., Tokushuku, K., Umemori, K., Yamada, S., Yamazaki, Y., Hamatsu, R., Hirose, T., Homma, K., Kitamura, S., Matsushita, T., Yamauchi, K., Cirio, R., Costa, M., Ferrero, M. I., Maselli, S., Monaco, V., Peroni, C., Petrucci, M. C., Sacchi, R., Solano, A., Staiano, A., Dardo, M., Bailey, D. C., Brkic, M., Fagerstroem, C. P., Hartner, G. F., Joo, K. K., Levman, G. M., Martin, J. F., Orr, R. S., Polenz, S., Sampson, C. R., Simmons, D., Teuscher, R. J., Butterworth, J. M., Catterall, C. D., Jones, T. W., Kaziewicz, P. B., Lane, J. B., Saunders, R. L., Shulman, J., Sutton, M. R., Lu, B., Mo, L. W., Ciborowski, J., Grzelak, G., Kasprzak, M., Muchorowski, K., Nowak, R. J., Pawlak, J. M., Pawlak, R., Tymieniecka, T., Wróblewski, A. K., Zakrzewski, J. A., Adamus, M., Coldewey, C., Eisenberg, Y., Hochman, D., Karshon, U., Revel, D., Badgett, W. F., Chapin, D., Cross, R., Dasu, S., Foudas, C., Loveless, R. J., Mattingly, S., Reeder, D. D., Smith, W. H., Vaiciulis, A., Wodarczyk, M., Bhadra, S., Frisken, W. R., Khakzad, M., Schmidke, W. B., and ZEUS Collaboration

Published
1997
Full Text
View/download PDF

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