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Background. Recent studies have confirmed the essential and paramount role of the L-Citrulline on the nitric oxide regulation and the endothelial function improvement.

INTRODUCTION: This study aimed to investigate the clinical and angiographic characteristics of patients with ST-elevation myocardial infarction who experienced primary percutaneous coronary intervention failure. METHOD: This retrospective observational study was derived from the Primary Angioplasty Registry of Sina Hospital (PARS). A total of 548 consecutive patients with ST-elevation myocardial infarction who underwent primary percutaneous coronary intervention between November 2016 and January 2019 were evaluated. Percutaneous coronary intervention failure was defined as Thrombolysis in Myocardial Infarction (TIMI) flow = 2 or corrected TIMI frame count (cTFC) = 28. RESULTS: The study population consisted of 458 (83.6%) males and 90 (16.4%) females with a mean age of 59.2 ± 12.49 years. TIMI flow 3 was achieved in 499 (91.1%) patients after the procedure, while 49 (8.9%) patients developed TIMI = 2. The findings showed that cTFC = 28 was present in 50 (9.1%) patients, while 489 (89.2%) patients had cTFC < 28. Multiple regression analysis shows that age 1.04 (1.01, 1.07), duration of pain onset to first medical contact time 1.04 (1.00, 1.18), and left anterior descending artery involvement 3.15 (1.21, 8.11) were independent predictors of TIMI = 2. CONCLUSION: Even though TIMI = 2 was uncommon among the study population, it was associated with adverse in-hospital outcomes. The results indicate that earlier emergency medical service arrival and shorter transfer time to the referral center can dramatically reduce the primary percutaneous coronary intervention failure rate. [ABSTRACT FROM AUTHOR]

Background: Electronic prescription is designed to complete the implementation of electronic health records, with the aim of increasing patient safety and improving the quality of hospital services, due to the interdisciplinary nature of this system and its numerous stakeholders, the implementation process is implemented with There are many complexities. Objective: This study was conducted to explain the challenges of copywriting and electronic screwing. Material and Methods: The present qualitative study was performed by phenomenological method in 2022-2023. The study data were collected through semistructured interviews with 25 key people in the field of treatment, staff and hospitals of Tehran University of Medical Sciences and analyzed through MAXQDA_10 software. Results: Challenges of implementing this program were categorized in 4 main themes and 8 sub-themes: policy preparation (policy secretariat formation, consensus building), policy formulation (formulation of policy content and policy advocacy), policy implementation (policy planning, policy execution) And policy evaluation (policy monitoring and policy evaluation). Conclusion: Develop integrated executive guidelines for existing challenges, educate and inform stakeholders, strengthen Internet infrastructure, progress intra-sectoral and cross-sectoral coordination, correct deficiencies related to service coding and update them, confidentiality of health data and the determination of the level of access to information and the participation of the private sector and its connection to the health data center are suggestions that can be helpful in solving the existing challenges. [ABSTRACT FROM AUTHOR]

Introduction: Occupational burnout among nurses is a major factor affecting the quality of nursing care. Assessing the prevalence of burnout and its related factors is necessary for discouraging the development of burnout., Aim: The aim of this study is determining the burnout among nurses of Ziaeian Hospital, which has not done before., Methods: In this cross-sectional study, all the nursing staff (287 people) was included after filling the informed consent. Occupational burnout was detected using the Maslach occupational burnout inventory tool. Data were analyzed by SPSS software and the significance threshold was set at p < 0.05., Results: Most of the subjects were female, married, had a bachelor's degree, worked as a nurse, and had less than 5 years of work experience. The mean score of emotional exhaustion was 29.25 ± 12.64, personal performance was 37.31 ± 7.9, and depersonalization was 14.7 ± 5.1. Altogether, 75% of the population had severe emotional exhaustion and depersonalization and mild personal dysfunction. The severity of emotional exhaustion, depersonalization and individual performance impairment weregreater in staff with higher degree. Job position also affected the intensity of emotional exhaustion and depersonalization. Additionally, there was a significant association between marital status and depersonalization., Conclusion: Nurses of Ziaeean Hospital have severe emotional exhaustion and depolarization; and mild personal function impairment. The findings of this research are a guide for the next steps to solve burnout in this hospital., Competing Interests: There are no conflicts of interest.