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2. Complexation and organization of doxorubicin on polystyrene sulfonate chains: impacts on doxorubicin dimerization and quenching

Author

Natalie Solfrid Gjerde, Alessandro Nicola Nardi, Cheng Giuseppe Chen, Paolo Di Gianvincenzo, Marco D’Abramo, Anita Scipioni, Luciano Galantini, Sergio E. Moya, and Mauro Giustini

Subjects
Doxorubicin, Polymers, General Physics and Astronomy, Polystyrenes, Water, Physical and Theoretical Chemistry, Dimerization
Abstract

Anthracycline doxorubicin hydrochloride (DX) is a positively charged fluorescent drug, which in water self-associates into non-fluorescent antiparallel dimers upon increasing concentration and/or ionic strength. The positive charge of DX allows for complexation with negatively charged polymers and drug carriers. The fluorescence of DX following complexation with polyanion polystyrene sulfonate (PSS) is studied here. The fluorescence emission of DX decreases in the presence of PSS, being almost completely quenched when the ratio (

Published
2022

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