Search

Your search keyword '"Natali, I"' showing total 96 results
Start Over Author "Natali, I"
96 results on '"Natali, I"'

3. Reduced prevalence of fetal exposure to alcohol in Italy: a nationwide survey

Author

Camandona, F, Vaccari, L, Travan, L, Maso, G, Stampalija, T, Zanazzo, L, Pisana, P, Driul, L, Barbui, E, Caissutti, C, Valente, E, Ricchi, A, Bettiga, E, Piccolo, E, Pati, M, Pedori, S, Antonazzo, P, Sottile, G, Lo Faro, F, Tini, A, Massacesi, M, Rapisarda, C, Vivirito, G, Pinna, G, D'Anna, M, Klein, L, Bucolo, A, D'Anna, R, Monaco, C, La Ferrera, G, Capobianco, G, Olzai, M, Angioni, S, D'Alterio, M, Serravalle, P, Vicquery, C, Scalchi, S, Morando, C, Meneghin, M, Scapolan, C, Maggino, T, Guarinoni, B, Cristina Napolitano, G, De Vita, M, Di Carlo, C, Interlandi, F, Bisceglia, M, Michelangelo, B, Arnulfo, A, Finale, E, Marozio, L, Natali, I, Grazia, S, Staffler, A, Tarani, L, Coriale, G, Messina, M, D'Angelo, A, Bonito, M, Haass, C, Capasso, L, Raimondi, F, De Bernardo, G, Iacobelli, P, Spadarella, S, Enrica, M, Rabuano, R, Calzatini, F, Bossi, A, Aversa, S, Prefumo, F, Bellan, C, Leone, G, Ciammella, M, Von-Wunster, S, Liguori, A, Ornaghi, S, Fumagalli, S, Sanguineti, F, Gianola, G, Cagnacci, A, Amidani, A, Sisto, A, Di Marcello, F, Santillo, V, Di Bartolomeo, C, Gerli, S, Cagnoli, G, Petrisano, M, Pesce, S, Di Lascio, N, Falvino, S, Appio, P, Targiani, V, Cavaliere, A, Turrini, I, Belli, G, Beatrice, G, Florio, P, Innocenti, E, Magi, L, Civitelli, F, Nappi, L, Sorrentino, F, Silvestris, T, Indrio, F, Laforgia, N, Rizzo, V, La Rocca, M, Pradal, U, Memo, L, Diaz, C, Riscica, P, Bazzo, S, La Maida, N, Di Giorgi, A, Pellegrini, M, Ceccanti, M, Caruso, S, Ricci, G, Neri, I, Lana, S, Minutillo, A, Berretta, P, Busardo, F, Pichini, S, Camandona F., Vaccari L., Travan L., Maso G., Stampalija T., Zanazzo L., Pisana P., Driul L., Barbui E., Caissutti C., Valente E., Ricchi A., Bettiga E., Piccolo E., Pati M., Pedori S., Antonazzo P., Sottile G., Lo Faro F., Tini A., Massacesi M., Rapisarda C., Vivirito G., Pinna G., D'anna M., Klein L., Bucolo A., D'Anna R., Monaco C., La Ferrera G., Capobianco G., Olzai M. G., Angioni S., D'Alterio M. N., Serravalle P., Vicquery C., Scalchi S., Morando C., Meneghin M., Scapolan C., Maggino T., Guarinoni B., Cristina Napolitano G. M., De Vita M. G., Di Carlo C., Interlandi F., Bisceglia M., Michelangelo B., Arnulfo A., Finale E., Marozio L., Natali I., Grazia S. M., Staffler A., Tarani L., Coriale G., Messina M. P., D'Angelo A., Bonito M., Haass C., Capasso L., Raimondi F., De Bernardo G., Iacobelli P., Spadarella S., Enrica M., Rabuano R., Calzatini F., Bossi A., Aversa S., Prefumo F., Bellan C., Leone G., Ciammella M., Von-Wunster S., Liguori A., Ornaghi S., Fumagalli S., Sanguineti F., Gianola G., Cagnacci A., Amidani A., Sisto A., Di Marcello F., Santillo V., Di Bartolomeo C., Gerli S., Cagnoli G., Petrisano M., Pesce S., Di Lascio N., Falvino S., Appio P., Targiani V., Cavaliere A. F., Turrini I., Belli G., Beatrice G., Florio P., Innocenti E. D., Magi L., Civitelli F., Nappi L., Sorrentino F., Silvestris T., Indrio F., Laforgia N., Rizzo V., La Rocca M., Pradal U., Memo L., Diaz C., Riscica P., Bazzo S., La Maida N., Di Giorgi A., Pellegrini M., Ceccanti M., Caruso S., Ricci G., Neri I., Lana S., Minutillo A., Berretta P., Busardo F. P., Pichini S., Camandona, F, Vaccari, L, Travan, L, Maso, G, Stampalija, T, Zanazzo, L, Pisana, P, Driul, L, Barbui, E, Caissutti, C, Valente, E, Ricchi, A, Bettiga, E, Piccolo, E, Pati, M, Pedori, S, Antonazzo, P, Sottile, G, Lo Faro, F, Tini, A, Massacesi, M, Rapisarda, C, Vivirito, G, Pinna, G, D'Anna, M, Klein, L, Bucolo, A, D'Anna, R, Monaco, C, La Ferrera, G, Capobianco, G, Olzai, M, Angioni, S, D'Alterio, M, Serravalle, P, Vicquery, C, Scalchi, S, Morando, C, Meneghin, M, Scapolan, C, Maggino, T, Guarinoni, B, Cristina Napolitano, G, De Vita, M, Di Carlo, C, Interlandi, F, Bisceglia, M, Michelangelo, B, Arnulfo, A, Finale, E, Marozio, L, Natali, I, Grazia, S, Staffler, A, Tarani, L, Coriale, G, Messina, M, D'Angelo, A, Bonito, M, Haass, C, Capasso, L, Raimondi, F, De Bernardo, G, Iacobelli, P, Spadarella, S, Enrica, M, Rabuano, R, Calzatini, F, Bossi, A, Aversa, S, Prefumo, F, Bellan, C, Leone, G, Ciammella, M, Von-Wunster, S, Liguori, A, Ornaghi, S, Fumagalli, S, Sanguineti, F, Gianola, G, Cagnacci, A, Amidani, A, Sisto, A, Di Marcello, F, Santillo, V, Di Bartolomeo, C, Gerli, S, Cagnoli, G, Petrisano, M, Pesce, S, Di Lascio, N, Falvino, S, Appio, P, Targiani, V, Cavaliere, A, Turrini, I, Belli, G, Beatrice, G, Florio, P, Innocenti, E, Magi, L, Civitelli, F, Nappi, L, Sorrentino, F, Silvestris, T, Indrio, F, Laforgia, N, Rizzo, V, La Rocca, M, Pradal, U, Memo, L, Diaz, C, Riscica, P, Bazzo, S, La Maida, N, Di Giorgi, A, Pellegrini, M, Ceccanti, M, Caruso, S, Ricci, G, Neri, I, Lana, S, Minutillo, A, Berretta, P, Busardo, F, Pichini, S, Camandona F., Vaccari L., Travan L., Maso G., Stampalija T., Zanazzo L., Pisana P., Driul L., Barbui E., Caissutti C., Valente E., Ricchi A., Bettiga E., Piccolo E., Pati M., Pedori S., Antonazzo P., Sottile G., Lo Faro F., Tini A., Massacesi M., Rapisarda C., Vivirito G., Pinna G., D'anna M., Klein L., Bucolo A., D'Anna R., Monaco C., La Ferrera G., Capobianco G., Olzai M. G., Angioni S., D'Alterio M. N., Serravalle P., Vicquery C., Scalchi S., Morando C., Meneghin M., Scapolan C., Maggino T., Guarinoni B., Cristina Napolitano G. M., De Vita M. G., Di Carlo C., Interlandi F., Bisceglia M., Michelangelo B., Arnulfo A., Finale E., Marozio L., Natali I., Grazia S. M., Staffler A., Tarani L., Coriale G., Messina M. P., D'Angelo A., Bonito M., Haass C., Capasso L., Raimondi F., De Bernardo G., Iacobelli P., Spadarella S., Enrica M., Rabuano R., Calzatini F., Bossi A., Aversa S., Prefumo F., Bellan C., Leone G., Ciammella M., Von-Wunster S., Liguori A., Ornaghi S., Fumagalli S., Sanguineti F., Gianola G., Cagnacci A., Amidani A., Sisto A., Di Marcello F., Santillo V., Di Bartolomeo C., Gerli S., Cagnoli G., Petrisano M., Pesce S., Di Lascio N., Falvino S., Appio P., Targiani V., Cavaliere A. F., Turrini I., Belli G., Beatrice G., Florio P., Innocenti E. D., Magi L., Civitelli F., Nappi L., Sorrentino F., Silvestris T., Indrio F., Laforgia N., Rizzo V., La Rocca M., Pradal U., Memo L., Diaz C., Riscica P., Bazzo S., La Maida N., Di Giorgi A., Pellegrini M., Ceccanti M., Caruso S., Ricci G., Neri I., Lana S., Minutillo A., Berretta P., Busardo F. P., and Pichini S.

Published
2023

9. 1-Allyl-4-hydroxy-2,2-dioxo-N-(4-methoxyphenyl)-1H-2λ6,1-benzothiazine-3-carboxamide: polymorphic transition due to grinding with the loss of the biological activity

Author

Svitlana V. Shishkina, Anna M. Shaposhnyk, Vyacheslav N. Baumer, Natali I. Voloshchuk, Pavlo S. Bondarenko, and Igor V. Ukrainets

Subjects
Materials Chemistry, Metals and Alloys, Atomic and Molecular Physics, and Optics, Electronic, Optical and Magnetic Materials
Abstract

A study of two polymorphic forms of 1-allyl-4-hydroxy-2,2-dioxo-N-(4-methoxyphenyl)-1-2λ6,1-benzothiazine-3-carboxamide (a structural analogue of piroxicam) has revealed some regularities in the crystal structure formation due to different evaporation rates from the tested solvents. The monoclinic polymorph crystallized from ethyl acetate is formed due to a large number of very weak C—H...O and C—H...π interactions as well as one strong stacking interaction. The triclinic polymorph crystallized from N,N-dimethylformamide is formed due to a small number of weak specific interactions and a maximal number of strong stacking interactions. The stacked dimer is a complex building unit in both polymorphic structures. Further analysis showed that the monoclinic structure is layered while the triclinic one is columnar. The two polymorphic structures also differ in their biological activity (antidiuretic and analgesic). The monoclinic polymorph possesses very high biological activity while the triclinic polymorph is almost inactive. The polymorphic transition of the biologically active metastable monoclinic structure into the inactive stable triclinic one within four weeks of grinding is caused by orientational factors rather than conformational ones and is accompanied by a change in the redistribution of interaction energies in the crystal from anisotropic to more isotropic. Thus, a slow polymorphic transition after grinding results in a loss of the biological activity.

Published
2022
Full Text
View/download PDF

10. Synthesis and Regularities of the Structure–Activity Relationship in a Series of N-Pyridyl-4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxamides

Author

Igor V. Ukrainets, Anna A. Burian, Ganna M. Hamza, Natali I. Voloshchuk, Oxana V. Malchenko, Svitlana V. Shishkina, Lyudmila V. Sidorenko, Kateryna O. Burian, and Galina Sim

Subjects
4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxamide, 2,1-benzothiazine, aminopyridines, crystal structure, molecular conformation, analgesic activity, anti-inflammatory action, Pharmacy and materia medica, RS1-441
Abstract

According to our quantum and chemical calculations 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylic acid imidazolide is theoretically almost as reactive as its 2-carbonyl analog, and it forms the corresponding N-pyridyl-4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxamides with many aminopyridines. However, in practice, the sulfo group introduces significant changes at times and prevents the acylation of sterically hindered amines. One of these products was 2-amino-6-methylpyridine. Thus, it has been concluded that aminopyridines interact with imidazolide in aromatic form where the target for the initial electrophilic attack is the ring nitrogen. To confirm the structure of all substances synthesized, 1H-NMR spectroscopy and X-ray diffraction analysis were used. From X-ray diffraction data it follows that in the crystalline phase the carbonyl and sulfo group may occupy different positions with respect to the plane of the benzothiazine bicycle: this position may be unilateral, typical for 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxamides, versatile, and not yet encountered in compounds of this type. A comparison of these data with the results of the pharmacological screening conducted on the standard model of carrageenan inflammation showed that the N-pyridylamides of the first group demonstrated a direct dependence of their analgesic and anti-inflammatory activity on the mutual arrangement of the planes of the benzothiazine and pyridine fragments. The new molecular conformation of the benzothiazine nucleus provides a sufficiently high level of analgesic (but not anti-inflammatory) properties in all N-pyridylamides of the second group with an extremely weak dependence on the spatial arrangement of the pyridine cycle. All substances presented this article proved themselves in varying degrees as analgesics and antiphlogistics. Moreover, two of them—N-(5-methylpyridin-2-yl)- and N-(pyridin-3-yl)-4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxamides—exceeded the most effective drug of oxicam type Lornoxicam by these indicators.

Published
2019
Full Text
View/download PDF

11. The Crystal Structure of N-(1-Arylethyl)-4-methyl- 2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxamides as the Factor Determining Biological Activity Thereof

Author

Igor V. Ukrainets, Ganna M. Hamza, Anna A. Burian, Natali I. Voloshchuk, Oxana V. Malchenko, Svitlana V. Shishkina, Irina A. Danylova, and Galina Sim

Subjects
4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylamide, 2,1-benzothiazine, chiral switches, crystal structure, molecular conformation, analgesic activity, anti-inflammatory action, Pharmacy and materia medica, RS1-441
Abstract

In order to detect new structural and biological patterns in a series of hetaryl-3-carboxylic acid derivatives, the optically pure (S)- and (R)-enantiomers of N-(1-arylethyl)-4-methyl- 2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxamides, their true racemates, and mechanical racemic mixtures have been synthesized in independent ways. The particular features of the 1Н- and 13С-NMR spectra of all synthesized substances, liquid chromato-mass spectrometric behavior thereof under electrospray ionization conditions, and also the results of polarimetric and X-ray diffraction studies have been discussed. Pharmacological screening on a model of carrageenan inflammation has found a clear relationship between the spatial structure of the studied objects and biological activity thereof. Enantiomers with chiral centers having (S)-configuration showed weak inhibition of pain and inflammatory reactions, while their mirror (R)-isomers exhibited very powerful analgesic and antiphlogistic properties under the same conditions, with the level of specific activity exceeding that of Lornoxicam and Diclofenac. Taking obtained data into account, a noticeable decrease in the activity of mechanical racemic mixtures, consisting of one-half of the “wrong„ (S)-enantiomers, is quite natural. The true racemate of N-(1-phenylethyl)-amide proved itself in a similar way, while 4-methoxy-substituted analog thereof stood out against this background with unexpectedly high analgesic and anti-inflammatory activities. A comparative analysis of X-ray diffraction data has found that crystalline and molecular structure of racemic N-[1-(4-methoxyphenyl)ethyl]-4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxamide is completely different from that of the original enantiomers and, moreover, very unusual for racemates. Obviously, it is the factor determining the unique character of the biological effects of the said substance.

Published
2019
Full Text
View/download PDF

14. Molecular Conformations and Biological Activity of N-Hetaryl(aryl)alkyl-4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxamides

Author

Igor V. Ukrainets, Ganna M. Hamza, Anna A. Burian, Natali I. Voloshchuk, Oxana V. Malchenko, Svitlana V. Shishkina, Lina A. Grinevich, Vasyl V. Grynenko, and Galina Sim

Subjects
4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylamide, 2,1-benzothiazine, crystal structure, molecular conformation, analgesic activity, anti-inflammatory action, Pharmacy and materia medica, RS1-441
Abstract

The analysis of our previous studies on the search for synthetic analgesics among N-R-amides of bicyclic hetaryl-3-carboxylic acids has been performed; on its basis N-hetaryl(aryl)-alkyl-4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxamides have been selected as new study objects. The “one pot synthesis„ of these compounds, which is simple to perform and at the same time highly effective, has been offered. The method consists in the initial reaction of 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylic acid and N,N′-carbonyldiimidazole in anhydrous N,N-dimethylformamide with the subsequent amidation of imidazolide formed with hetarylalkyl- or benzylamines in the same solvent. The peculiarities of 1H- and 13C-NMR spectra of the substances obtained, as well as their electrospray ionization liquid chromato-mass spectra are discussed. According to the results of the pharmacological tests carried out on the model of carrageenan inflammation it has been found that all without exception N-hetaryl(aryl)alkyl-4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxamides demonstrate the statistically significant analgesic and anti-inflammatory properties. Among the substances presented in this article analgesics and antiphlogistics, which increase the pain threshold and suppress the inflammatory response more effectively than Lornoxicam and Diclofenac in the same doses, have been identified. The molecular and crystal structures of a large group of the substances synthesized have been studied by X-ray diffraction analysis. Comparison of these data with the results of biological tests has revealed the fact of excellent correlation between the molecular conformations of N-hetaryl(aryl)alkyl-4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxamides recorded in the crystal and the potency of their analgesic effect. N-Thiophen-2-ylmethyl- and N-4-methoxybenzyl-amides of 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylic acid has shown a high analgesic and anti-inflammatory effect, therefore, they deserve more careful research.

Published
2018
Full Text
View/download PDF

15. Synthesis, Crystal Structure, and Biological Activity of Ethyl 4-Methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylate Polymorphic Forms

Author

Igor V. Ukrainets, Anna A. Burian, Vyacheslav N. Baumer, Svitlana V. Shishkina, Lyudmila V. Sidorenko, Igor A. Tugaibei, Natali I. Voloshchuk, and Pavlo S. Bondarenko

Subjects
alkylation, esters, 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylic acid, 2,1-benzothiazine, crystal structure, polymorphism, anti-inflammatory action, analgesic activity, Pharmacy and materia medica, RS1-441
Abstract

Continuing the search for new potential analgesics among the derivatives of 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylic acid, the possibility of obtaining its esters by the alkylation of the corresponding sodium salt with iodoethane in dimethyl sulfoxide (DMSO) at room temperature was studied. It was found that under such conditions, together with the oxygen atom of the carboxyl group, a heteroatom of nitrogen is also alkylated. Therefore, the product of the reaction studied is a mixture of ethyl 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylate (major) and its 1-ethyl-substituted analog (minor). A simple but very effective method of preparative separation of these compounds was proposed. Moreover, the heterogeneous crystallization from ethanol was revealed to result in a monoclinic polymorphic form of ethyl 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylate, while the homogeneous crystallization results in its orthorhombic form. The molecular and crystal structures of both forms were confirmed by X-ray diffraction analysis, and the phase purity by powder diffraction study. The pharmacological tests carried out on the model of a carrageenan edema showed that the screening dose of 20 mg/kg of 1-ethyl-substituted ester and the orthorhombic form of its analog unsubstituted in position 1 exhibited weak anti-inflammatory and moderate analgesic effects. At the same time, the monoclinic form of ethyl 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylate appeared to be both a powerful analgesic and an anti-inflammatory agent that exceeded Piroxicam and Meloxicam in the same doses by these indicators. A detailed comparative analysis of the molecular and crystal structures of two polymorphic forms of ethyl 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylate was carried out using quantum chemical calculations of the energies of pairwise interactions between molecules. An explanation of the essential differences of their biological properties based on this was offered.

Published
2018
Full Text
View/download PDF

16. 4-Methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylic Acid. Peculiarities of Preparation, Structure, and Biological Properties

Author

Igor V. Ukrainets, Ganna M. Hamza, Anna A. Burian, Svitlana V. Shishkina, Natali I. Voloshchuk, and Oxana V. Malchenko

Subjects
esters, hydrolysis, 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylic acid, 2,1-benzothiazine, crystal structure, anti-inflammatory action, analgesic activity, Pharmacy and materia medica, RS1-441
Abstract

In order to determine the regularities of the structure–analgesic activity relationship, the peculiarities of obtaining, the spatial structure, and biological properties of 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylic acid and some of its derivatives have been studied. Using nuclear magnetic resonance (NMR) spectroscopy and X-ray diffraction analysis, it has been proven that varying the reaction conditions using alkaline hydrolysis of methyl 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylate makes it possible to successfully synthesize a monohydrate of the target acid, its sodium salt, or 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine. The derivatographic study of the thermal stability of 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylic acid monohydrate has been carried out; based on this study, the optimal conditions completely eliminating the possibility of unwanted decomposition have been proposed for obtaining its anhydrous form. It has been shown that 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine is easily formed during the decarboxylation of not only 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylic acid, but also its sodium salt, which is capable of losing СО2 both in rather soft conditions of boiling in an aqueous solution, and in more rigid conditions of dry heating. The NMR spectra of the compounds synthesized are given; their spatial structure is discussed. To study the biological properties of 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylic acid and its sodium salt, the experimental model of inflammation caused by subplantar introduction of the carrageenan solution in one of the hind limbs of white rats was used. The anti-inflammatory activity and analgesic effect were assessed by the degree of edema reduction and the ability to affect the pain response compared to the animals of control groups. According to the results of the tests performed, it has been found that after intraperitoneal injection, the substances synthesized demonstrate a moderate anti-inflammatory action and simultaneously increase the pain threshold of the experimental animals very effectively, exceeding Lornoxicam and Diclofenac in a similar dose by their analgesic activity.

Published
2018
Full Text
View/download PDF

18. 1-Allyl-4-hydroxy-2,2-dioxo-N-(4-methoxyphenyl)-1H-2λ

Author

Svitlana V, Shishkina, Anna M, Shaposhnyk, Vyacheslav N, Baumer, Natali I, Voloshchuk, Pavlo S, Bondarenko, and Igor V, Ukrainets

Subjects
Analgesics, Piroxicam, Molecular Conformation, Crystallography, X-Ray
Abstract

A study of two polymorphic forms of 1-allyl-4-hydroxy-2,2-dioxo-N-(4-methoxyphenyl)-1-2λ

Published
2021

22. Mortality, survival and incidence rates in the ITALUNG randomised lung cancer screening trial

Author

Paci, E, Puliti, D, Zappa, M, Ocello, C, Manneschi, G, Visioli, C, Cordopatri, G, Giusti, F, Esposito, I, Pegna, Al, Bianchi, R, Ronchi, C, Carrozzi, Laura, Aquilini, F, Cini, S, De Santis, M, Pistelli, F, Baliva, F, Chella, A, Tavanti, L, Grazzini, M, Innocenti, F, Natali, I, Mascalchi, M, Bartolucci, M, Crisci, E, De Francisci, A, Falchini, M, Gabbrielli, S, Roselli, G, Masi, A, Falaschi, F, Battola, L, De Liperi, A, Spinelli, C, Vannucchi, L, Petruzzelli, A, Gadda, D, Neri, At, Niccolai, F, Vaggelli, L, Vella, A, Carozzi, Fm, Maddau, C, Bisanzi, S, Picozzi, G, Janni, A, Mussi, Alfredo, Lucchi, Marco, Comin, C, Fontanini, Gabriella, Tognetti, Ar, Iacuzio, L, Caldarella, A, Barchielli, A, and Goldoni, Ca

Subjects
Pulmonary and Respiratory Medicine, medicine.medical_specialty, business.industry, Incidence (epidemiology), Lung Cancer, medicine.disease, Rate ratio, Surgery, Cancer registry, 03 medical and health sciences, 0302 clinical medicine, 030228 respiratory system, 030220 oncology & carcinogenesis, Internal medicine, Statistical significance, medicine, Clinical Epidemiology, Overdiagnosis, business, Lung cancer, Lung cancer screening, Cause of death
Abstract

Background ITALUNG is contributing to the European evaluation of low-dose CT (LDCT) screening for lung cancer (LC). Methods Eligible subjects aged 55–69 years, smokers or ex-smokers (at least 20 pack-years in the last 10 years), were randomised to receive an annual invitation for LDCT screening for 4 years (active group) or to usual care (control group). All participants were followed up for vital status and cause of death (at the end of 2014) and LC incidence (at the end of 2013). Pathological and clinical information was collected from the Tuscan Cancer Registry data. Results 1613 subjects were randomly assigned to the active group and 1593 to the control group. At the end of the follow-up period 67 LC cases were diagnosed in the active group and 71 in the control group (rate ratio (RR)=0.93; 95% CI 0.67 to 1.30). A greater proportion of stage I LC was observed in the active group (36% vs 11%, p Conclusions Despite the lack of statistical significance, the ITALUNG trial outcomes suggest that LDCT screening could reduce LC and overall mortality. Moreover, the comparison of the number of LC cases diagnosed in the two groups does not show overdiagnosis after an adequate follow-up period. A pooled analysis of all European screening trials is advocated to assess the benefit-to-harm ratio of LDCT screening and its implementation in public health settings. Trial registration number Results, NCT02777996.

Published
2017
Full Text
View/download PDF

23. 1‐Allyl‐4‐hydroxy‐2,2‐dioxo‐N‐(4‐methoxyphenyl)‐1H‐2λ6,1‐benzothiazine‐3‐carboxamide: polymorphic transition due to grinding with the loss of the biological activity

Author

Shishkina, Svitlana V., Shaposhnyk, Anna M., Baumer, Vyacheslav N., Voloshchuk, Natali I., Bondarenko, Pavlo S., and Ukrainets, Igor V.

Subjects
STACKING interactions, ANISOTROPIC crystals, CRYSTAL structure, PIROXICAM
Abstract

A study of two polymorphic forms of 1‐allyl‐4‐hydroxy‐2,2‐dioxo‐N‐(4‐methoxyphenyl)‐1‐2λ6,1‐benzothiazine‐3‐carboxamide (a structural analogue of piroxicam) has revealed some regularities in the crystal structure formation due to different evaporation rates from the tested solvents. The monoclinic polymorph crystallized from ethyl acetate is formed due to a large number of very weak C—H...O and C—H...π interactions as well as one strong stacking interaction. The triclinic polymorph crystallized from N,N‐dimethylformamide is formed due to a small number of weak specific interactions and a maximal number of strong stacking interactions. The stacked dimer is a complex building unit in both polymorphic structures. Further analysis showed that the monoclinic structure is layered while the triclinic one is columnar. The two polymorphic structures also differ in their biological activity (antidiuretic and analgesic). The monoclinic polymorph possesses very high biological activity while the triclinic polymorph is almost inactive. The polymorphic transition of the biologically active metastable monoclinic structure into the inactive stable triclinic one within four weeks of grinding is caused by orientational factors rather than conformational ones and is accompanied by a change in the redistribution of interaction energies in the crystal from anisotropic to more isotropic. Thus, a slow polymorphic transition after grinding results in a loss of the biological activity. [ABSTRACT FROM AUTHOR]

Published
2022
Full Text
View/download PDF

26. 4-Methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylic Acid. Peculiarities of Preparation, Structure, and Biological Properties

Author

Anna A. Burian, Igor V. Ukrainets, Ganna M. Hamza, Svitlana V. Shishkina, Oxana V. Malchenko, and Natali I. Voloshchuk

Subjects
esters, hydrolysis, 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylic acid, 2,1-benzothiazine, crystal structure, anti-inflammatory action, analgesic activity, Decarboxylation, Carboxylic acid, lcsh:RS1-441, Pharmaceutical Science, Benzothiazine, 010403 inorganic & nuclear chemistry, 01 natural sciences, Article, lcsh:Pharmacy and materia medica, chemistry.chemical_compound, Hydrolysis, Alkaline hydrolysis, chemistry.chemical_classification, Aqueous solution, 010405 organic chemistry, 0104 chemical sciences, Carrageenan, chemistry, Anhydrous, Nuclear chemistry
Abstract

In order to determine the regularities of the structure–analgesic activity relationship, the peculiarities of obtaining, the spatial structure, and biological properties of 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylic acid and some of its derivatives have been studied. Using nuclear magnetic resonance (NMR) spectroscopy and X-ray diffraction analysis, it has been proven that varying the reaction conditions using alkaline hydrolysis of methyl 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylate makes it possible to successfully synthesize a monohydrate of the target acid, its sodium salt, or 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine. The derivatographic study of the thermal stability of 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylic acid monohydrate has been carried out; based on this study, the optimal conditions completely eliminating the possibility of unwanted decomposition have been proposed for obtaining its anhydrous form. It has been shown that 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine is easily formed during the decarboxylation of not only 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylic acid, but also its sodium salt, which is capable of losing СО2 both in rather soft conditions of boiling in an aqueous solution, and in more rigid conditions of dry heating. The NMR spectra of the compounds synthesized are given; their spatial structure is discussed. To study the biological properties of 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylic acid and its sodium salt, the experimental model of inflammation caused by subplantar introduction of the carrageenan solution in one of the hind limbs of white rats was used. The anti-inflammatory activity and analgesic effect were assessed by the degree of edema reduction and the ability to affect the pain response compared to the animals of control groups. According to the results of the tests performed, it has been found that after intraperitoneal injection, the substances synthesized demonstrate a moderate anti-inflammatory action and simultaneously increase the pain threshold of the experimental animals very effectively, exceeding Lornoxicam and Diclofenac in a similar dose by their analgesic activity.

Published
2018
Full Text
View/download PDF

30. Crystal Habits and Biological Properties of N-(4-Trifluoromethylphenyl)-4-Hydroxy-2,2-Dioxo-1H-2λ6,1-Benzothiazine-3-Carboxamide

Author

Lyudmila V. Sidorenko, Igor V. Ukrainets, Svitlana V. Shishkina, L. A. Petrushova, Andrii I. Fedosov, Natali I. Voloshchuk, Galina Sim, and Pavlo S. Bondarenko

Subjects
crystal structure, medicine.drug_class, Stereochemistry, Analgesic, Ethyl acetate, Pharmaceutical Science, Carboxamide, Crystal structure, Benzothiazine, Acute toxicity, Crystal, chemistry.chemical_compound, chemistry, 2,1-benzothiazine, medicine, crystal habitus, 4-hydroxy-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxamide, Crystal habit, analgesic activity
Abstract

In order to study polymorphic modifications of N-(4-trifluoromethylphenyl)-4-hydroxy-2,2-dioxo-1H-2&lambda, 6,1-benzothiazine-3-carboxamide, which is of interest as a promising analgesic, its three colorless crystal forms with different habitus have been obtained: sticks of ethyl acetate, plates of meta-xylene and blocks of ortho-xylene. However, the X-ray diffraction analysis has shown that all the forms studied have the identical molecular and crystal structure in spite of such significant differences in appearance. Moreover, pharmacological tests have revealed significant differences in the analgesic activity in these samples (a total of five experimental models were used: &ldquo, acetic-acid-induced writhing&rdquo, &ldquo, hot plate&rdquo, thermal irritation of the tail tip&rdquo, (tail-flick), &ldquo, tail electric stimulation&rdquo, and &ldquo, neuropathic pain&rdquo, ), acute toxicity and the ability to cause gastric damage. As a result, only the plate crystal form of N-(4-trifluoromethylphenyl)-4-hydroxy-2,2-dioxo-1H-2&lambda, 6,1-benzothiazine-3-carboxamide is recommended for further studies. Thus, it has been proven that the habitus of crystals is an important characteristic of the drug substance and is able to have a noticeable effect on its biological properties. Changes in habitus should be considered as a guide to the mandatory verification of at least the basic pharmacological parameters of the new form regardless of whether the molecular and crystal structure changes.

Published
2019
Full Text
View/download PDF

31. Biological properties of two enantiomorphic forms of N‐(2,6‐dimethylphenyl)‐4‐hydroxy‐2,2‐dioxo‐1H‐2λ6,1‐benzothiazine‐3‐carboxamide, a structural analogue of piroxicam.

Author

Shishkina, Svitlana V., Ukrainets, Igor V., Vashchenko, Olga V., Voloshchuk, Natali I., Bondarenko, Pavlo S., Petrushova, Lidiya A., and Sim, Galina

Subjects
MOLECULAR structure, MIRROR images, HYDROGEN bonding, SPACE groups, BIOLOGICAL laboratories, ATOMS
Abstract

The title benzothiazine‐3‐carboxamide, C17H16N2O4S, crystallized in two enantiomorphic crystal forms with the space groups P32 and P31 despite the absence of a classic stereogenic atom. The molecular structures are mirror images of each other. Only one sulfonyl O atom takes part in intramolecular hydrogen bonding as a proton acceptor and this atom is different in the two enantiomorphic structures. As a result, the S atom becomes a pseudo‐stereogenic centre. This fact is worth taking into account due to the different biological activities of the enantiomorphic forms. One form possesses a high analgesic activity, while the other form revealed a high anti‐inflammatory activity. [ABSTRACT FROM AUTHOR]

Published
2020
Full Text
View/download PDF

33. Efficiency evaluation of nano-structured consolidants on Carrara marble by field exposure tests

Author

Bonazza, A., Vidorni, G., Natali, I., Giosuè, C., Tittarelli, F., and Sabbioni, C.

Subjects
field exposure tests, metal alkoxide, nano-based materials, Carrara marble, field exposure tests, consolidating treatment, metal alkoxide, nano-based materials, consolidating treatment, Carrara marble, NO
Abstract

In the context of a changing environment, the preservation of outdoor built heritage is increasingly threatened. Furthermore the application of conservation products does not always achieve the expected results. Furthermore, preliminary tests aimed at evaluating the performance of new products often show them to be inappropriate. In such situations, the paper reports the outcomes of an innovative methodology adopted to assess the efficiency and durability of nano-based consolidating products utilized for the conservation of carbonate artworks, carrying out field exposure tests on Carrara Marble model samples in different sites. Surface properties, superficial cohesion, distribution and penetration of the conservation products and their interactions with substrates and environmental conditions were examined and compared with the features of undamaged samples and of artificially damaged samples.

Published
2016

35. Consolidation tests on the graffiti of the Steri’s prison with nanotechnological Ca(OH)2 dispersed in iso-propanol

Author

Natali, I, Dei, L., SALADINO, Maria Luisa, CAPONETTI, Eugenio, Natali, I, Dei, L., Saladino, M.L., and Caponetti E.

Subjects
wall paintings conservation, Ca(OH)2, nanoparticles, consolidation, Settore CHIM/02 - Chimica Fisica
Abstract

The combination of weathering and human activities often induce pyhisicochemical alteration on the surface of wall paintings. One of the most still largely used restoration techniques for these works of art, is based on the application of organic polymers. Due to their ability to stick detached and powdered pigments,these products provide an immediate consolidating effects. Unfortunately, both their aging and their pyhisicochemical incompatibility with the inorganic support can have serious consequences also causing further damage to the work of art. In this paper a new technological approach is presented based on the use of Ca(OH)2 nanoparticles dispersed in isopropanol. Some applicative test have been carried out onto the graffiti in the Steri’s prison in Palermo. After the application of the nanoparticles, SEM/EDX and water absorption tests indicate that the transpiration of the wall was maintained and that the open pores were not completely clogged, confirming that the nanolime dispersions is a good chemically compatible consolidant for wall paintings.

Published
2009

36. Development of metal-alkoxides precursors for conservation nanomaterials: the EU project NANOMATCH

Author

Bernardi A., Becherini F., Bonazza A., Chiurato M., Favaro M., Natali I., Tomasin P., Vivarelli A., Nijland T., García O., Detalle V., Wittstadt K., Romero Sanchez M.D., Pockelé L., Verhey B., Brinkmann U., de' Micheli G., Labouré M., Möller B., and Olteanu I.D.

Abstract

Deterioration of historic building materials has become more and more important since climate change has worsened the natural decay and the impact of atmospheric pollution. On the basis of these premises, the three-year European Collaborative Project NANOMATCH addresses this issue through the development of innovative consolidants specifically designed to meet the requirements of the historic building substrates, especially focusing on stone, wall paintings, wood and glass, and integrated in high performance products to renovate the market dedicated to the conservation of the built heritage.

Published
2014

37. [Untitled]

Author

I. V. Chikalovets, Alexander V. Khomenko, Nelly A. Odintsova, P. A. Luk’yanov, and Natali I. Belogortseva

Subjects
biology, Cell adhesion molecule, Cell growth, Growth factor, medicine.medical_treatment, Clinical Biochemistry, Cell, Lectin, Tumor cells, Cell Biology, General Medicine, biology.organism_classification, Cell biology, HeLa, Dose–response relationship, medicine.anatomical_structure, medicine, biology.protein, Molecular Biology
Abstract

Cell adhesion molecules, some of which are lectins, play a key role in the control of normal and pathological processes of various living organisms. We found herein that N‐acetyl‐D‐glucosamine‐specific lectin, isolated from the ascidian Didemnum ternatanum (DTL), alters the growth properties of HeLa tumor cells depending on the anchorage. DTL was shown to increase the proliferation of HeLa cells grown in soft agar greatly (in anchorage‐independent fashion). In contrast, DTL inhibits the proliferative activity of HeLa cells grown on solid substrate and acts as inductor of differentiation, slowing cell growth, increasing the cell attachment and spreading. Scanning electron microscopic data have demonstrated that DTL treatment resulted in pronounced changes of the shape and surface of HeLa cells. Changes of cellular morphology correlated with essential redistribution of actin microfilaments.

Published
2001
Full Text
View/download PDF

38. Four-year results of low-dose CT screening and nodule management in the ITALUNG trial

Author

Lopes Pegna, A, Picozzi, G, Falaschi, Fabio, Carrozzi, Laura, Falchini, M, Carozzi, Fm, Pistelli, F, Comin, C, Deliperi, A, Grazzini, M, Innocenti, F, Maddau, C, Vella, A, Vaggelli, L, Paci, E, Mascalchi, M, Bianchi, R, Ronchi, C, Aquilini, F, Cini, S, De Santis, M, Baliva, F, Chella, A, Tavanti, L, Natali, I, Bartolucci, M, Crisci, E, De Francisci, A, Gabbrielli, S, Roselli, G, Masi, A, Battola, L, Spinelli, C, Vannucchi, L, Petruzzelli, A, Gadda, D, Neri, At, Niccolai, F, Janni, A, Mussi, Alfredo, Lucchi, Marco, Fontanini, Gabriella, Tognetti, Ar, Cordopatri, G, Giusti, F, and Esposito, I.

Published
2013

39. <italic>GDF9</italic> gene polymorphism and its association with litter size in two Russian sheep breeds.

Author

Gorlov, Ivan F., Kolosov, Yuri A., Shirokova, Nadezhda V., Getmantseva, Lyubov V., Slozhenkina, Marina I., Mosolova, Natali I., Bakoev, Nekruz F., Leonova, Maria A., Kolosov, Anatoli Yu., and Zlobina, Elena Yu.

Abstract

The purpose of this work was to study the GDF9 gene polymorphism in two sheep breeds raised in Russia and to identify its association with litter size. A variety of allelic variants of the GDF9 gene (GDF9/G1 and GDF9/G4 sites) in Salsk and Volgograd sheep breeds was studied. Mutations of the GDF9 gene that lead to improvement of reproductive traits in these sheep breeds were revealed. The obtained results of the alleles and genotypes frequencies for the GDF9 gene showed a low level of polymorphism at G1 and G4 sites. The studied populations were found to have high frequencies of G allele and GG genotype at G1 site and of A allele and AA genotype at G4 site of the GDF9 gene. Herewith all the individuals heterozygous at G1 site were also heterozygous at G4 site. Homozygous AA (G1) and GG (G4) genotypes in the study population were not observed. In the Salsk sheep population the individuals with AG genotype at G1 site had the highest fertility. A similar pattern was observed at G4 site. The litter size of Salsk sheep with GG genotype (G1) was 1.13. Among the Volgograd sheep, the individuals with AG genotype were also characterized by the highest fertility; the litter size of the individuals with the GG genotype (G1) was 1.22. A similar pattern was observed at G4 site. The litter size of animals with AG genotype was 1.88 and the AA genotype − 1.22. Thus, the positive and significant relation between the heterozygous AG/GDF9 genotype and litter size of animals has been established. [ABSTRACT FROM AUTHOR]

Published
2018
Full Text
View/download PDF

40. High variability in results of semen analysis in andrology laboratories in Tuscany (Italy): the experience of an external quality control (EQC) programme

Author

Filimberti, E., Degl Innocenti, S., Borsotti, M., Quercioli, M., Piomboni, P., Natali, I., Fino, M. G., Caglieresi, C., Criscuoli, L., Loredana GANDINI, Biggeri, A., Maggi, M., and Baldi, E.

Subjects
Male, Quality Control, Italy, spermatozoa, Semen, Sperm Motility, Humans, Andrology, Laboratories, semen analysis, quality control
Abstract

We report the results of the first three trials of an external quality control (EQC) programme performed in 71 laboratories executing semen analysis in Tuscany Region (Italy). At the end of the second trial, participants were invited to attend a teaching course illustrating and inviting to adhere to procedures recommended by WHO (V edition). Results of the first three trials of the EQC documented a huge variability in the procedures and the results. The highest variability was found for morphology (CV above 80% for all the trials), followed by count (CV of about 60% for all the trials) and motility (CV below 30% for all the trials). When results of sperm count and morphology were divided according to the used method, mean CV values did not show significant differences. CV for morphology dropped significantly at the third trial for most methods, indicating the usefulness of the teaching course for morphology assessment. Conversely, no differences were observed after the course for motility and for most methods to evaluate count, although CV values were lower at the second and third trial for the laboratories using the Burker cytometer. When results were divided according to tertiles of activity, the lowest mean bias values (difference between each laboratory result and the median value of the results) for count and morphology were observed for laboratories in the third tertile (performing over 200 semen analysis/year). Of interest, mean bias values for concentration dropped significantly at the third trial for low activity laboratories. In conclusion, lack of agreement of results of semen analysis in Tuscany is mainly because of the activity and the experience of the laboratory. Our study points out the importance of participating in EQC programmes and periodical teaching courses as well as the use of WHO recommended standardized procedures to increase precision and to allow the use of WHO reference values.

Published
2012

43. Screening per il cancro del polmone con tomografia computerizzata (CT scan) a bassa dose: studio controllato randomizzato Italung-CT. Stato di avanzamento del progetto. Risultati al 30.06.2008

Author

Lopes Pegna, A, Aquilini, F, Bartolucci, M, Bianchi, R, Carozzi, Fm, Carrozzi, L, Comin, Ec, Cordopatri, G, De Francisci, A, Esposito, I, Falchini, M, Falaschi, F, Fontanini, G, Grazzini, M, Innocenti, F, Mascalchi, M, Masi, A, Natali, I, Picozzi, G, Pistelli, F, Ronchi, Mc, Roselli, G, Spinelli, C, Venturi, C, and Paci, E

Published
2008

45. Andrology

Author

Carchenilla, M. S. C., primary, Agudo, D., additional, Rubio, S., additional, Becerra, D., additional, Bronet, F., additional, Garcia-Velasco, J. A., additional, Pacheco, A., additional, Lardone, M., additional, Piottante, A., additional, Parada-Bustamante, A., additional, Argandona, F., additional, Florez, M., additional, Espinoza, A., additional, Ebensperger, M., additional, Castro, A., additional, Cohen-Bacrie, M., additional, Belloc, S., additional, Dalleac, A., additional, Amar, E., additional, Izard, V., additional, Hazout, A., additional, Cohen-Bacrie, P., additional, de Mouzon, J., additional, Muzzonigro, F., additional, Crivello, A. M., additional, Stanghellini, I., additional, Bernardini, L., additional, Ferraretti, A. P., additional, Magli, C., additional, Gianaroli, L., additional, Martin, P. S., additional, Duvison, M. H., additional, Silva, M. D., additional, Gosalvez, J., additional, Martin, F. S., additional, Pomante, A., additional, Colombo, F., additional, Mattioli, M., additional, Barboni, B., additional, Magli, M. C., additional, Hacifazlioglu, O., additional, Findikli, N., additional, Goktolga, U., additional, Bahceci, M., additional, Jakab, A., additional, Mokanszki, A., additional, Varga, A., additional, Benyo, M., additional, Kassai, Z., additional, Olah, E., additional, Molnar, Z., additional, Gundogan, G. I., additional, Bozkurt, H. H., additional, Irez, T., additional, Domingo, A., additional, Anarte, C., additional, Presilla, N., additional, Calvo, I., additional, Aguirre, O., additional, Oroquieta, A., additional, Agirregoikoa, J. A., additional, De Pablo, J. L., additional, Barrenetxea, G., additional, Moragues, I., additional, Medrano, M. L., additional, Montoya, A., additional, Ramos, B., additional, Torres, M. J. G., additional, Aizpurua, J., additional, Ibala, S. R., additional, Ghedir, H., additional, Mehri, A., additional, Zidi, I., additional, Brahem, S., additional, Mehdi, M., additional, Ajina, M., additional, Saad, A., additional, Gomez-Torres, M. J., additional, Cavaco, J. E., additional, Rato, L., additional, Alves, M. G., additional, Dias, T. R., additional, Lopes, G., additional, Socorro, S., additional, Oliveira, P. F., additional, Lobascio, A. M., additional, Minasi, M. G., additional, Greco, E., additional, Bungum, M., additional, Bungum, A., additional, Silver, N., additional, Zahiri, M., additional, Movahedin, M., additional, Mowla, S. J., additional, Noruzinia, M., additional, Huleihel, M., additional, Abarbanel, Y., additional, Haber, E. P., additional, Azab, M., additional, Lan, D., additional, Lunenfeld, E., additional, Smith, M. J., additional, Neri, Q. V., additional, Harvey, L., additional, Rosenwaks, Z., additional, Palermo, G. D., additional, Alhalabi, M., additional, Samawi, S., additional, Droubi, H., additional, Khalaf, M., additional, Taha, A., additional, Khatib, R., additional, Bednarowska-flisiak, A., additional, Wcislo, M., additional, Liss, J., additional, Swider, A., additional, Szczyglinska, J., additional, Grzymkowska, M., additional, Bruszczynska, A., additional, Glowacka, J., additional, Kitowska-Marszalkowska, K., additional, Krapchev, M., additional, Mirecka, A., additional, Wisniewska, K., additional, Lukaszuk, K., additional, Natali, I., additional, Tamburrino, L., additional, Cambi, M., additional, Marchiani, S., additional, Noci, I., additional, Maggi, M., additional, Forti, G., additional, Baldi, E., additional, Muratori, M., additional, Ferraretto, X., additional, Pasquet, B., additional, Damond, F., additional, Matheron, S., additional, Epelboin, S., additional, Yahi, S., additional, Demailly, P., additional, Rougier, N., additional, Yazbeck, C., additional, Delaroche, L., additional, Longuet, P., additional, Llabador, M., additional, Estellat, C., additional, Patrat, C., additional, Askarijahromi, M., additional, Amanlu, M., additional, Mowla, S. j., additional, Mazaheri, Z., additional, Christensen, P., additional, Sills, E. S., additional, Fischer, R., additional, Naether, O. G. J., additional, Walsh, D., additional, Rudolf, K., additional, Coull, G., additional, Baukloh, V., additional, Labouriau, R., additional, Birck, A., additional, Parisi, F., additional, Parrilla, B., additional, Oneta, M., additional, Savasi, V., additional, Veleva, L., additional, Milachich, T., additional, Bochev, I., additional, Antonova, I., additional, Shterev, A., additional, Vlaisavljevic, V., additional, Breznik, B. P., additional, Kovacic, B., additional, Serrano, M., additional, Gonzalvo, M. C., additional, Clavero, A., additional, Fernandez, M. F., additional, Mozas, J., additional, Martinez, L., additional, Fontes, J., additional, Carrillo, S., additional, Lopez-Regalado, M. L., additional, Lopez-Leria, B., additional, Orozco, I., additional, Mantilla, A., additional, Castilla, J. A., additional, Mskhalaya, G., additional, Zakharova, E., additional, Zaletova, V., additional, Kasatonova, E., additional, Melnik, Y., additional, Efremov, E., additional, Schiewe, M. C., additional, Verheyen, G., additional, Tournaye, H., additional, Phletincx, I., additional, Sims, C. A., additional, Rothman, C., additional, Borges, E., additional, Setti, A. S., additional, Braga, D. P. A. F., additional, Vingris, L., additional, Iaconelli, A., additional, Dupont, C., additional, Faure, C., additional, Sermondade, N., additional, Gautier, B., additional, Herbemont, C., additional, Aknin, I., additional, Klein, J. P., additional, Cedrin-Durnerin, I., additional, Wolf, J. P., additional, Czernichow, S., additional, Levy, R., additional, Rondanino, C., additional, Chauffour, C., additional, Ouchchane, L., additional, Artonne, C., additional, Janny, L., additional, Lobaccaro, J. M., additional, Volle, D. H., additional, Brugnon, F., additional, Colacurci, N., additional, Piomboni, P., additional, Ruvolo, G., additional, Lombardo, F., additional, Verde, E. L., additional, De Leo, V., additional, Lispi, M., additional, Papaleo, E., additional, De Palo, R., additional, Gandini, L., additional, Longobardi, S., additional, Yokota, Y., additional, Yokota, M., additional, Yokota, H., additional, Araki, Y., additional, Alshahrani, S., additional, Durairajanayagam, D., additional, Sharma, R., additional, Sabanegh, E., additional, Agarwal, A., additional, Hattori, H., additional, Nakajo, Y., additional, Ikeno, T., additional, Sato, Y., additional, Kyoya, T., additional, Kyono, K., additional, Li, B., additional, Li, J. B., additional, Xiao, X. F., additional, Ma, Y. F., additional, Wang, J., additional, Liang, X. X., additional, Zhao, H. X., additional, Jiang, F., additional, Yao, Y. Q., additional, Wang, X. H., additional, Roan, N. R., additional, Liu, H., additional, Muller, J., additional, Avila-Herrera, A., additional, Pollard, K. S., additional, Lishko, P., additional, Kirchhoff, F., additional, Munch, J., additional, Witkowska, H. E., additional, Greene, W. C., additional, Mangiarini, A., additional, Paffoni, A., additional, Restelli, L., additional, Guarneri, C., additional, Somigliana, E., additional, Ragni, G., additional, Bou, R., additional, Aleman, M., additional, Guardiola, F., additional, Camargo, C., additional, Oliveira, J. B. A., additional, Petersen, C. G., additional, Mauri, A. L., additional, Massaro, F. C., additional, Nicoletti, A., additional, Nascimento, A. M., additional, Vagnini, L. D., additional, Martins, A. M. V. C., additional, Cavagna, M., additional, Baruffi, R. L. R., additional, and Franco, J. G., additional

Published
2013
Full Text
View/download PDF

48. Corrigenda

Author

Dang, Hai-Shan, primary, Diart, Val�rie, additional, Roberts, Brian P., additional, Lukyanenko, Nikolai G., additional, Pastushok, Victor N., additional, Bordunov, Andrei V., additional, Vetrogon, Victor I., additional, Vetrogon, Natali I., additional, and Bradshaw, Jerald S., additional

Published
1994
Full Text
View/download PDF

49. Corrigenda

Author

Hai-Shan Dang, Val�rie Diart, Brian P. Roberts, Nikolai G. Lukyanenko, Victor N. Pastushok, Andrei V. Bordunov, Victor I. Vetrogon, Natali I. Vetrogon, and Jerald S. Bradshaw

Published
1994
Full Text
View/download PDF

50. New phenol-containing bis(azacrown ether)s: synthesis and complexing properties

Author

Jerald S. Bradshaw, Natali I. Vetrogon, Victor Vetrogon, Nikolai G. Lukyanenko, Andrei V. Bordunov, and Victor N. Pastushok

Subjects
Ether, Alkali metal, Ring (chemistry), Medicinal chemistry, Inclusion compound, Metal, chemistry.chemical_compound, chemistry, visual_art, visual_art.visual_art_medium, Organic chemistry, Phenol, Titration, Phenols
Abstract

A simple synthesis of phenol-containing bis(azacrown ethers) by the treatment of N-methoxymethyl-substituted azacrowns with phenols has been elaborated. Temperature conditions have been found for selectively introducing into one phenolic ring both one and two monoazacrown ether substituents. New symmetric 14a–e and asymmetric 15 phenol-bridged bis(azacrown ether)s exhibited strong complexation abilities towards both alkali and especially alkaline-earth metal cations. All measurements have been carried out using the pH-metric titration technique. Complexation constant values in neutral (K1) and in alkaline (K2) media are in the order: monocyclic 1b–d K1. These results show participation of phenolic ions in the complex formation process. In an alkaline medium, bis(azacrown ether)s 14b, 14e and 14d showed high selectivity towards Li+, Ba+2 and Sr+2, respectively.

Published
1994
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results