1. Association of Serum Leptin and Adiponectin Concentrations with Type 2 Diabetes Biomarkers and Complications Among Saudi Women
- Author
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Mohammed Saeed W and Nasser Binjawhar D
- Subjects
adiponectin ,cardiovascular disease ,insulin resistance ,leptin ,obesity ,type 2 diabetes ,Specialties of internal medicine ,RC581-951 - Abstract
Walaa Mohammed Saeed,1 Dalal Nasser Binjawhar2 1Department of Medical Laboratory Technology, Faculty of Applied Medical Science, Taibah University, Tayba, Medina, 42353, Saudi Arabia; 2Department of Chemistry, College of Science, Princess Nourah bint Abdulrahman University, Riyadh, 11671, Saudia ArabiaCorrespondence: Dalal Nasser Binjawhar, Email dnbanjawhar@pnu.edu.saObjective: Hyperglycemia and insulin resistance (IR) put obese women with Type 2 diabetes mellitus (T2DM) at risk for cardiovascular disease (CVD).Methods: 150 T2DM women aged 30– 45 were studied cross-sectionally at Madinah Hospital lab to find T2DM risk factors and their association with adiponectin/leptin levels.Results: Women with T2DM showed greater fasting blood glucose (FBG), hemoglobin A1c (HbA1c), triglycerides (TG), body mass index (BMI), waist circumference (WC), insulin resistance (IR), high-sensitivity C-reactive protein (hs-CRP), and CVD risk (high atherogenic index of plasma (AIP) and leptin), but decreased high-density lipoprotein (HDL-cholesterol) and poor insulin sensitivity with low adiponectin. Obese women with T2DM had increased leptin and reduced adiponectin. Leptin levels were significantly related to IR, BMI, and AIP (B= 3.97, P= 0.02) but not WC. Leptin levels were negatively correlated with insulin sensitivity (IS) and HDL-c (P
- Published
- 2023