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1. Defatting of donor transplant livers during normothermic perfusion—a randomised clinical trial: study protocol for the DeFat study

Author

Abbas, Syed Hussain, Ceresa, Carlo D. L., Hodson, Leanne, Nasralla, David, Watson, Christopher J. E., Mergental, Hynek, Coussios, Constantin, Kaloyirou, Fotini, Brusby, Kerrie, Mora, Ana, Thomas, Helen, Kounali, Daphne, Keen, Katie, Pollok, Joerg-Matthias, Gaurav, Rohit, Iype, Satheesh, Jassem, Wayel, Perera, M. Thamara PR, Hakeem, Abdul Rahman, Knight, Simon, and Friend, Peter J.

Published
2024
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8. Post Living Donor Liver Transplantation Small-for-size Syndrome: Definitions, Timelines, Biochemical, and Clinical Factors for Diagnosis: Guidelines From the ILTS-iLDLT-LTSI Consensus Conference

Author

Kow, Alfred Wei Chieh, Liu, Jiang, Patel, Madhukar S., De Martin, Eleonora, Reddy, Mettu Srinivas, Soejima, Yuji, Syn, Nicholas, Watt, Kymberly, Xia, Qiang, Saraf, Neeraj, Kamel, Refaat, Nasralla, David, McKenna, Greg, Srinvasan, Parthi, Elsabbagh, Ahmed M., Pamecha, Vinayendra, Palaniappan, Kumar, Mas, Valeria, Tokat, Yaman, Asthana, Sonal, Cherukuru, Ramkiran, Egawa, Hiroto, Lerut, Jan, Broering, Dieter, Berenguer, Marina, Cattral, Mark, Clavien, Pierre-Alain, Chen, Chao-Long, Shah, Samir, Zhu, Zhi-Jun, Emond, Jean, Ascher, Nancy, Rammohan, Ashwin, Bhangui, Prashant, Rela, Mohamed, Kim, Dong-sik, and Ikegami, Toru

Published
2023
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9. Enhanced recovery for liver transplantation: recommendations from the 2022 International Liver Transplantation Society consensus conference

Author

Mayr, Andreas, Dominguez, Beatriz, Muller, Elmi, Rando, Karina, Enoch, Mary Anne, Tamir, Noam, Healy, Pamela, Manser, Tanja, Briggs, Tim, Chaudhary, Abhideep, Humar, Abhinav, Jafarian, Ali, Soin, Arvinder Singh, Eghtesad, Bijan, Miller, Charles, Cherqui, Daniel, Samuel, Didier, Broering, Dieter, Pomfret, Elizabeth, Villamil, Federico, Durand, Francois, Berlakovich, Gabriela, McCaughan, Geoffrey, Auzinger, Georg, Testa, Giuliano, Klintmalm, Goran, Belghiti, Jacques, Findlay, James, Lai, Jennifer, Fung, John, Klinck, John, Roberts, John, Liu, Linda, Cattral, Mark, Ghobrial, Mark, Selzner, Markus, Ramsay, Michael, Rela, Mohamed, Ascher, Nancy, Man, Nancy Kwan, Selzner, Nazia, Burra, Patrizia, Friend, Peter, Busuttil, Ronald, Hwang, Shin, McCluskey, Stuart, Mas, Valeria, Vohra, Vijay, Vij, Vivek, Merritt, William, Tokat, Yaman, Kang, Yoogoo, Chan, Albert, Mazzola, Alessandra, Hessheimer, Amelia, Rammohan, Ashwin, Hogan, Brian, Vinaixa, Carmen, Nasralla, David, Victor, David, De Martin, Eleonora, Alconchel, Felipe, Roll, Garrett, Kabacam, Gokhan, Sapisochin, Gonzalo, Campos-Varela, Isabel, Liu, Jiang, Patel, Madhukar S., Izzy, Manhal, Kalisvaart, Marit, Adams, Megan, Goldaracena, Nicholas, Tinguely, Pascale, Hernandez-Alejandro, Roberto, Chadha, Ryan, Shaker, Tamer Mahmoud, Klair, Tarunjeet S., Pan, Terry, Tanaka, Tomohiro, Yoon, Uzung, Kirchner, Varvara, Hannon, Vivienne, Cheah, Yee Lee, Frola, Carlo, Morkane, Clare, Milliken, Don, Lurje, Georg, Potts, Jonathan, Fernandez, Thomas, Badenoch, Adam, Mukhtar, Ahmed, Zanetto, Alberto, Montano-Loza, Aldo, Chieh, Alfred Kow Wei, Shetty, Amol, DeWolf, Andre, Olmos, Andrea, Mrzljak, Anna, Blasi, Annabel, Berzigotti, Annalisa, Malik, Ashish, Rajakumar, Akila, Davidson, Brian, O'Farrell, Bryan, Kotton, Camille, Imber, Charles, Kwon, Choon Hyuck David, Wray, Christopher, Ahn, Chul-Soo, Krenn, Claus, Quintini, Cristiano, Maluf, Daniel, Mina, Daniel Santa, Sellers, Daniel, Balci, Deniz, Patel, Dhupal, Rudow, Dianne LaPointe, Monbaliu, Diethard, Bezinover, Dmitri, Krzanicki, Dominik, Kim, Dong-Sik, Brombosz, Elizabeth, Blumberg, Emily, Weiss, Emmanuel, Wey, Emmanuel, Kaldas, Fady, Saliba, Faouzi, Pittau, Gabriella, Wagener, Gebhard, Song, Gi-Won, Biancofiore, Gianni, Crespo, Gonzalo, Rodríguez, Gonzalo, Palli, Graciela Martinez, McKenna, Gregory, Petrowsky, Henrik, Egawa, Hiroto, Montasser, Iman, Pirenne, Jacques, Eason, James, Guarrera, James, Pomposelli, James, Lerut, Jan, Emond, Jean, Boehly, Jennifer, Towey, Jennifer, Hillingsø, Jens G, de Jonge, Jeroen, Caicedo, Juan, Heimbach, Julie, Emamaullee, Juliet Ann, Bartoszko, Justyna, Ma, Ka Wing, Kronish, Kate, Forkin, Katherine T., Chok, Kenneth Siu Ho, Olthoff, Kim, Reyntjens, Koen, Lee, Kwang-Woong, Suh, Kyung-Suk, Denehy, Linda, van der Laan, Luc J.W., McCormack, Lucas, Gorvin, Lucy, Ruffolo, Luis, Bhat, Mamatha, Ramírez, María Amalia Matamoros, Londoño, Maria-Carlota, Gitman, Marina, Levstik, Mark, de Santibañes, Martin, Lindsay, Martine, Parotto, Matteo, Armstrong, Matthew, Kasahara, Mureo, Schofield, Nick, Rizkalla, Nicole, Akamatsu, Nobuhisa, Scatton, Olivier, Keskin, Onur, Imventarza, Oscar, Andacoglu, Oya, Muiesan, Paolo, Giorgio, Patricia, Northup, Patrick, Matins, Paulo, Abt, Peter, Newsome, Philip N, Dutkowski, Philipp, Bhangui, Pooja, Bhangui, Prashant, Tandon, Puneeta, Brustia, Raffaele, Planinsic, Raymond, Brown, Robert, Porte, Robert, Barth, Rolf, Ciria, Rubén, Florman, Sander, Dharancy, Sebastien, Pai, Sher-Lu, Yagi, Shintaro, Nadalin, Silvio, Chinnakotla, Srinath, Forbes, Stuart J, Rahman, Suehana, Hong, Suk Kyun, Liying, Sun, Orloff, Susan, Rubman, Susan, Eguchi, Susumu, Ikegami, Toru, Reichman, Trevor, Settmacher, Utz, Aluvihare, Varuna, Xia, Victor, Yoon, Young-In, Soejima, Yuji, Genyk, Yuri, Jalal, Arif, Borakati, Aditya, Gustar, Adrian, Mohamed, Ahmed, Ramirez, Alejandro, Rothnie, Alex, Scott, Aneya, Sharma, Anika, Munro, Annalise, Mahay, Arun, Liew, Belle, Hidalgo, Camila, Crouch, Cara, Yan, Cheung Tsz, Tschuor, Christoph, Shaw, Conrad, Schizas, Dimitrios, Fritche, Dominic, Huda, Fabia Ferdousi, Wells, Gemma, Farrer, Giselle, Kwok, Hiu Tat, Kostakis, Ioannis, Mestre-Costa, Joao, Fan, Ka Hay, Fan, Ka Siu, Fraser, Kyra, Jeilani, Lelia, Pang, Li, Lenti, Lorenzo, Kathirvel, Manikandan, Zachiotis, Marinos, Vailas, Michail, Milan, Michele Mazza, Elnagar, Mohamed, Alradhawi, Mohammad, Dimitrokallis, Nikolaos, Machairas, Nikolaos, Morare, Nolitha, Yeung, Oscar, Khanal, Pragalva, Satish, Pranav, Ghani, Shahi Abdul, Makhdoom, Shahroo, Arulrajan, Sithhipratha, Bogan, Stephanie, Pericleous, Stephanos, Blakemore, Timon, Otti, Vanessa, Lam, Walter, Jackson, Whitney, Abdi, Zakee, Pollok, Joerg M, Berenguer, Marina, Niemann, Claus U, Raptis, Dimitri A, and Spiro, Michael

Published
2023
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11. Mechanisms underlying the efficacy of normothermic machine perfusion in human liver transplantation

Author

Nasralla, David and Friend, Peter

Subjects
617.5, Liver transplantation, Normothermic perfusion, Preservation of organs, tissues, etc.
Abstract

Introduction: By perfusing a liver with oxygenated blood, medications and nutrients at 37C, normothermic machine perfusion (NMP) may improve outcomes after liver transplantation when compared with conventional static cold storage (SCS). Herein is reported the first randomised controlled trial (RCT) comparing continuous NMP with SCS in human liver transplantation. Additional work exploring the mechanisms behind the effects of NMP is also described. Methods: This multinational RCT was initiated by the Consortium for Organ Preservation in Europe (COPE) and involved seven European transplant centres. Adult DBD and type III DCD livers were randomly assigned (1:1) to continuous NMP or SCS. The primary end point was the difference in peak-AST, requiring 220 transplants (90% power). Secondary endpoints included: organ utilisation, preservation time, early allograft dysfunction (EAD), six month graft and patient survival and ischaemic cholangiopathy on MRCP. During NMP, perfusate and bile samples were collected and subsequently analysed to provide information regarding bile salt utilisation and identify markers that may indicate organ quality. Results: 272 livers (135 SCS, 137 NMP) were enrolled, consisting of 194 DBD and 78 DCD organs. 48 livers were discarded (32 SCS [15 DBD, 17 DCD] vs 16 NMP [10 DBD, 6 DCD]; p=0.01). NMP livers experienced significantly longer preservation times than SCS (7hr 21min vs 11hr 39min; p< 0.01). Despite this, better early graft function was observed in the NMP group with regards to peak AST (974 IU/L SCS vs 485IU/L NMP; p< 0.001) and EAD (29.9% SCS vs 12.6% NMP; p=0.002) with the magnitude of these effects being greater for DCD organs (p=0.02). No measurable difference was found in radiological rates of ischaemic cholangiopathy with no demonstrable correlation between MRCP findings and clinically relevant strictures. NMP livers were found to utilise bovine bile salts effectively with bile production and several other biochemical parameters found to correlate with graft quality. Discussion: NMP livers show better early graft function than SCS in terms of peak-AST and EAD, both of which are surrogates for long-term graft outcomes. This is despite better organ utilisation and longer preservation times in the NMP group. NMP can be used to predict organ quality although it is not possible to draw conclusions about markers that may predict viability. If translated to clinical practice, these results would have a major impact on liver transplant outcomes and waiting list mortality. The fact that the study has definitively met its primary endpoint should now enable the exploration of the technology's wider potential.

Published
2018

13. Impact of SARS-CoV-2 pandemic on pancreatic cancer services and treatment pathways: United Kingdom experience

Author

McKay, Siobhan C., Pathak, Samir, Wilkin, Richard J.W., Kamarajah, Sivesh K., Wigmore, Stephen J., Rees, Jonathan, Dunne, Declan F.J., Garcea, Giuseppe, Ahmad, Jawad, de Liguori Carino, Nicola, Sultana, Asma, Silva, Mike, Lykoudis, Pavlos, Nasralla, David, Milburn, James, Shah, Nehal, Kocher, Hemant M., Bhogal, Ricky, Baron, Ryan D., Navarro, Alex, Halle-Smith, James, Al-Sarireh, Bilal, Sen, Gourab, Jamieson, Nigel B., Briggs, Christopher, Stell, David, Aroori, Somaiah, Bowles, Matthew, Kanwar, Aditya, Harper, Simon, Menon, Krishna, Prachalias, Andreas, Srinivasan, Parthi, Frampton, Adam E., Jones, Claire, Arshad, Ali, Tait, Iain, Spalding, Duncan, Young, Alastair L., Durkin, Damien, Ghods-Ghorbani, Manijeh, Sutcliffe, Robert P., and Roberts, Keith J.

Published
2021
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14. Proceedings of the 26th Annual Virtual Congress of the International Liver Transplantation Society

Author

Kalisvaart, Marit, Chadha, Ryan, De Martin, Eleonora, Alconchel, Felipe, Goldaracena, Nicolas, Keskin, Onur, Liu, Jiang, Nasralla, David, Mazzola, Alessandra, Rammohan, Ashwin, Spiro, Michael, Tanaka, Tomohiro, Campos-Varela, Isabel, Victor, David, Vinaixa, Carmen, Yoon, Uzung, Yoon, Young-in, Hessheimer, Amelia, Kabacam, Gokhan, Sapisochin, Gonzalo, Shaker, Tamer, Bhangui, Prashant, Chan, Albert, and Kirchner, Varvara

Published
2022
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15. Piperacillin/tazobactam for surgical prophylaxis during pancreatoduodenectomy: meta-analysis.

Author

Kumar, Jayant, Reccia, Isabella, Carneiro, Adriano, Podda, Mauro, Virdis, Francesco, Machairas, Nikolaos, Nasralla, David, Arasaradnam, Ramesh P, Poon, Kenneth, Gannon, Christopher J, Fung, John J, Habib, Nagy, and Llaguna, Omar

Subjects
TAZOBACTAM, PIPERACILLIN, ANTIBIOTIC prophylaxis, PANCREATICODUODENECTOMY, PANCREATIC fistula, SURGICAL complications
Abstract

Background Pancreatoduodenectomy is associated with an increased incidence of surgical-site infections, often leading to a significant rise in morbidity and mortality. This trend underlines the inadequacy of traditional antibiotic prophylaxis strategies. Hence, the aim of this meta-analysis was to assess the outcomes of antimicrobial prophylaxis, comparing piperacillin/tazobactam with traditional antibiotics. Methods Upon registering in PROSPERO, the international prospective register of systematic reviews (CRD42023479100), a systematic search of various databases was conducted over the interval 2000–2023. This inclusive search encompassed a wide range of study types, including prospective and retrospective cohorts and RCTs. The subsequent data analysis was carried out utilizing RevMan 5.4. Results A total of eight studies involving 2382 patients who underwent pancreatoduodenectomy and received either piperacillin/tazobactam (1196 patients) or traditional antibiotics (1186 patients) as antibiotic prophylaxis during surgery were included in the meta-analysis. Patients in the piperacillin/tazobactam group had significantly reduced incidences of surgical-site infections (OR 0.43 (95% c.i. 0.30 to 0.62); P < 0.00001) and major surgical complications (Clavien–Dindo grade greater than or equal to III) (OR 0.61 (95% c.i. 0.45 to 0.81); P = 0.0008). Subgroup analysis of surgical-site infections highlighted significantly reduced incidences of superficial surgical-site infections (OR 0.34 (95% c.i. 0.14 to 0.84); P = 0.02) and organ/space surgical-site infections (OR 0.47 (95% c.i. 0.28 to 0.78); P = 0.004) in the piperacillin/tazobactam group. Further, the analysis demonstrated significantly lower incidences of clinically relevant postoperative pancreatic fistulas (grades B and C) (OR 0.67 (95% c.i. 0.53 to 0.83); P = 0.0003) and mortality (OR 0.51 (95% c.i. 0.28 to 0.91); P = 0.02) in the piperacillin/tazobactam group. Conclusion Piperacillin/tazobactam as antimicrobial prophylaxis significantly lowers the risk of postoperative surgical-site infections, major surgical complications (complications classified as Clavien–Dindo grade greater than or equal to III), clinically relevant postoperative pancreatic fistulas (grades B and C), and mortality, hence supporting the implementation of piperacillin/tazobactam for surgical prophylaxis in current practice. [ABSTRACT FROM AUTHOR]

Published
2024
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16. Global management of a common, underrated surgical task during the COVID-19 pandemic: Gallstone disease - An international survery

Author

Al Alawy, Yousef, Arif, Abdul Jabba, Attia, Magdy, Bhati, Chandra, Battula R, Narendra, Bonney, Glenn Kunnath, Brooke-Smith, Mark, Derosas, Carlos, De Liguori Carino, Nicola, Ferretti, Stefano, Fiorani, Cristina, Gherardi, Dario, Hegab, Bassem, Hussain, Zaki, Ielpo, Benedetto, Iesari, Samuele, Lai, Quirino, Lainas, Panagiotis, Lauterio, Andrea, Lazzaro, Alessandra, Marudanayagam, Ravi, Nasralla, David, Nicolini, Daniele, Orlando, Giuseppe, Patrono, Damiano, Pitchaimuthu, Maheswaran, Polak, Wojciech, Quinto, Alberto Marcacuzco, Rai, Rakesh, Scalera, Irene, Schlegel, Andrea, Shanmugam, Vivek, Vitale, Alessandro, Widmer, Jeannette, Yannick, Deswysen, Manzia, Tommaso Maria, Angelico, Roberta, Parente, Alessandro, Muiesan, Paolo, and Tisone, Giuseppe

Published
2020
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17. Proceedings of the 28th Annual Congress of the International Liver Transplantation Society

Author

Shaji Mathew, Johns, primary, Shingina, Alexandra, additional, Khan, Mohammad Qasim, additional, Wilson, Elizabeth, additional, Syn, Nicholas, additional, Rammohan, Ashwin, additional, Alconchel, Felipe, additional, Hakeem, Abdul Rahman, additional, Shankar, Sadhana, additional, Patel, Dhupal, additional, Keskin, Onur, additional, Liu, Jiang, additional, Nasralla, David, additional, Mazzola, Alessandra, additional, Patel, Madhukar S., additional, Tanaka, Tomohiro, additional, Victor, David, additional, Yoon, Uzung, additional, Yoon, Young-in, additional, Vinaixa, Carmen, additional, Kirchner, Varvara, additional, De Martin, Eleonora, additional, Ghobrial, R. Mark, additional, and Chadha, Ryan, additional

Published
2024
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19. British Transplantation Society guidelines on abdominal organ transplantation from deceased donors after circulatory death

Author

Phillips, Benedict, primary, Asgari, Ellie, additional, Berry, Miriam, additional, Callaghan, Chris, additional, Cerisuelo, Miriam Cortes, additional, Johnson, Paul, additional, Karydis, Nikolaos, additional, Nasralla, David, additional, Nutu, Anisu, additional, Oniscu, Gabi, additional, Perera, Thamara, additional, Sinha, Sanjay, additional, Sutherland, Andrew, additional, Van Dellen, David, additional, Watson, Chris, additional, White, Steve, additional, and O'Neill, Stephen, additional

Published
2023
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20. Proceedings of the 27th Annual Congress of the International Liver Transplantation Society

Author

Campos-Varela, Isabel, primary, Rammohan, Ashwin, additional, Chadha, Ryan, additional, Alconchel, Felipe, additional, Hakeem, Abdul R., additional, Mathew, Johns S., additional, Goldaracena, Nicolas, additional, Syn, Nicholas, additional, Shankar, Sadhana, additional, Patel, Dhupal, additional, Keskin, Onur, additional, Liu, Jiang, additional, Nasralla, David, additional, Mazzola, Alessandra, additional, Shingina, Alexandra, additional, Spiro, Michael, additional, Patel, Madhukar S., additional, Tanaka, Tomohiro, additional, Victor, David, additional, Yoon, Uzung, additional, Yoon, Young-in, additional, Shaker, Tamer, additional, Vinaixa, Carmen, additional, Kirchner, Varvara A., additional, and De Martin, Eleonora, additional

Published
2023
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22. A randomized trial of normothermic preservation in liver transplantation

Author

Nasralla, David, Coussios, Constantin C., Mergental, Hynek, Akhtar, M. Zeeshan, Butler, Andrew J., Ceresa, Carlo D. L., and Chiocchia, Virginia

Subjects
Liver transplantation -- Methods, Aspartate, Enzymes, Surgery, Organ transplantation, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

Liver transplantation is a highly successful treatment, but is severely limited by the shortage in donor organs. However, many potential donor organs cannot be used; this is because sub-optimal livers do not tolerate conventional cold storage and there is no reliable way to assess organ viability preoperatively. Normothermic machine perfusion maintains the liver in a physiological state, avoids cooling and allows recovery and functional testing. Here we show that, in a randomized trial with 220 liver transplantations, compared to conventional static cold storage, normothermic preservation is associated with a 50% lower level of graft injury, measured by hepatocellular enzyme release, despite a 50% lower rate of organ discard and a 54% longer mean preservation time. There was no significant difference in bile duct complications, graft survival or survival of the patient. If translated to clinical practice, these results would have a major impact on liver transplant outcomes and waiting list mortality.Normothermic machine perfusion of the liver improved early graft function, demonstrated by reduced peak serum aspartate transaminase levels and early allograft dysfunction rates, and improved organ utilization and preservation times, although no differences were seen in graft or patient survival., Author(s): David Nasralla [sup.1] , Constantin C. Coussios [sup.2] , Hynek Mergental [sup.3] , M. Zeeshan Akhtar [sup.1] [sup.4] , Andrew J. Butler [sup.5] , Carlo D. L. Ceresa [sup.1] [...]

Published
2018
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25. Enhanced recovery for liver transplantation: recommendations from the 2022 International Liver Transplantation Society consensus conference

Author

Pollok, Joerg M, primary, Tinguely, Pascale, additional, Berenguer, Marina, additional, Niemann, Claus U, additional, Raptis, Dimitri A, additional, Spiro, Michael, additional, Mayr, Andreas, additional, Dominguez, Beatriz, additional, Muller, Elmi, additional, Rando, Karina, additional, Enoch, Mary Anne, additional, Tamir, Noam, additional, Healy, Pamela, additional, Manser, Tanja, additional, Briggs, Tim, additional, Chaudhary, Abhideep, additional, Humar, Abhinav, additional, Jafarian, Ali, additional, Soin, Arvinder Singh, additional, Eghtesad, Bijan, additional, Miller, Charles, additional, Cherqui, Daniel, additional, Samuel, Didier, additional, Broering, Dieter, additional, Pomfret, Elizabeth, additional, Villamil, Federico, additional, Durand, Francois, additional, Berlakovich, Gabriela, additional, McCaughan, Geoffrey, additional, Auzinger, Georg, additional, Testa, Giuliano, additional, Klintmalm, Goran, additional, Belghiti, Jacques, additional, Findlay, James, additional, Lai, Jennifer, additional, Fung, John, additional, Klinck, John, additional, Roberts, John, additional, Liu, Linda, additional, Cattral, Mark, additional, Ghobrial, Mark, additional, Selzner, Markus, additional, Ramsay, Michael, additional, Rela, Mohamed, additional, Ascher, Nancy, additional, Man, Nancy Kwan, additional, Selzner, Nazia, additional, Burra, Patrizia, additional, Friend, Peter, additional, Busuttil, Ronald, additional, Hwang, Shin, additional, McCluskey, Stuart, additional, Mas, Valeria, additional, Vohra, Vijay, additional, Vij, Vivek, additional, Merritt, William, additional, Tokat, Yaman, additional, Kang, Yoogoo, additional, Chan, Albert, additional, Mazzola, Alessandra, additional, Hessheimer, Amelia, additional, Rammohan, Ashwin, additional, Hogan, Brian, additional, Vinaixa, Carmen, additional, Nasralla, David, additional, Victor, David, additional, De Martin, Eleonora, additional, Alconchel, Felipe, additional, Roll, Garrett, additional, Kabacam, Gokhan, additional, Sapisochin, Gonzalo, additional, Campos-Varela, Isabel, additional, Liu, Jiang, additional, Patel, Madhukar S., additional, Izzy, Manhal, additional, Kalisvaart, Marit, additional, Adams, Megan, additional, Goldaracena, Nicholas, additional, Hernandez-Alejandro, Roberto, additional, Chadha, Ryan, additional, Shaker, Tamer Mahmoud, additional, Klair, Tarunjeet S., additional, Pan, Terry, additional, Tanaka, Tomohiro, additional, Yoon, Uzung, additional, Kirchner, Varvara, additional, Hannon, Vivienne, additional, Cheah, Yee Lee, additional, Frola, Carlo, additional, Morkane, Clare, additional, Milliken, Don, additional, Lurje, Georg, additional, Potts, Jonathan, additional, Fernandez, Thomas, additional, Badenoch, Adam, additional, Mukhtar, Ahmed, additional, Zanetto, Alberto, additional, Montano-Loza, Aldo, additional, Chieh, Alfred Kow Wei, additional, Shetty, Amol, additional, DeWolf, Andre, additional, Olmos, Andrea, additional, Mrzljak, Anna, additional, Blasi, Annabel, additional, Berzigotti, Annalisa, additional, Malik, Ashish, additional, Rajakumar, Akila, additional, Davidson, Brian, additional, O'Farrell, Bryan, additional, Kotton, Camille, additional, Imber, Charles, additional, Kwon, Choon Hyuck David, additional, Wray, Christopher, additional, Ahn, Chul-Soo, additional, Krenn, Claus, additional, Quintini, Cristiano, additional, Maluf, Daniel, additional, Mina, Daniel Santa, additional, Sellers, Daniel, additional, Balci, Deniz, additional, Patel, Dhupal, additional, Rudow, Dianne LaPointe, additional, Monbaliu, Diethard, additional, Bezinover, Dmitri, additional, Krzanicki, Dominik, additional, Kim, Dong-Sik, additional, Brombosz, Elizabeth, additional, Blumberg, Emily, additional, Weiss, Emmanuel, additional, Wey, Emmanuel, additional, Kaldas, Fady, additional, Saliba, Faouzi, additional, Pittau, Gabriella, additional, Wagener, Gebhard, additional, Song, Gi-Won, additional, Biancofiore, Gianni, additional, Crespo, Gonzalo, additional, Rodríguez, Gonzalo, additional, Palli, Graciela Martinez, additional, McKenna, Gregory, additional, Petrowsky, Henrik, additional, Egawa, Hiroto, additional, Montasser, Iman, additional, Pirenne, Jacques, additional, Eason, James, additional, Guarrera, James, additional, Pomposelli, James, additional, Lerut, Jan, additional, Emond, Jean, additional, Boehly, Jennifer, additional, Towey, Jennifer, additional, Hillingsø, Jens G, additional, de Jonge, Jeroen, additional, Caicedo, Juan, additional, Heimbach, Julie, additional, Emamaullee, Juliet Ann, additional, Bartoszko, Justyna, additional, Ma, Ka Wing, additional, Kronish, Kate, additional, Forkin, Katherine T., additional, Chok, Kenneth Siu Ho, additional, Olthoff, Kim, additional, Reyntjens, Koen, additional, Lee, Kwang-Woong, additional, Suh, Kyung-Suk, additional, Denehy, Linda, additional, van der Laan, Luc J.W., additional, McCormack, Lucas, additional, Gorvin, Lucy, additional, Ruffolo, Luis, additional, Bhat, Mamatha, additional, Ramírez, María Amalia Matamoros, additional, Londoño, Maria-Carlota, additional, Gitman, Marina, additional, Levstik, Mark, additional, de Santibañes, Martin, additional, Lindsay, Martine, additional, Parotto, Matteo, additional, Armstrong, Matthew, additional, Kasahara, Mureo, additional, Schofield, Nick, additional, Rizkalla, Nicole, additional, Akamatsu, Nobuhisa, additional, Scatton, Olivier, additional, Keskin, Onur, additional, Imventarza, Oscar, additional, Andacoglu, Oya, additional, Muiesan, Paolo, additional, Giorgio, Patricia, additional, Northup, Patrick, additional, Matins, Paulo, additional, Abt, Peter, additional, Newsome, Philip N, additional, Dutkowski, Philipp, additional, Bhangui, Pooja, additional, Bhangui, Prashant, additional, Tandon, Puneeta, additional, Brustia, Raffaele, additional, Planinsic, Raymond, additional, Brown, Robert, additional, Porte, Robert, additional, Barth, Rolf, additional, Ciria, Rubén, additional, Florman, Sander, additional, Dharancy, Sebastien, additional, Pai, Sher-Lu, additional, Yagi, Shintaro, additional, Nadalin, Silvio, additional, Chinnakotla, Srinath, additional, Forbes, Stuart J, additional, Rahman, Suehana, additional, Hong, Suk Kyun, additional, Liying, Sun, additional, Orloff, Susan, additional, Rubman, Susan, additional, Eguchi, Susumu, additional, Ikegami, Toru, additional, Reichman, Trevor, additional, Settmacher, Utz, additional, Aluvihare, Varuna, additional, Xia, Victor, additional, Yoon, Young-In, additional, Soejima, Yuji, additional, Genyk, Yuri, additional, Jalal, Arif, additional, Borakati, Aditya, additional, Gustar, Adrian, additional, Mohamed, Ahmed, additional, Ramirez, Alejandro, additional, Rothnie, Alex, additional, Scott, Aneya, additional, Sharma, Anika, additional, Munro, Annalise, additional, Mahay, Arun, additional, Liew, Belle, additional, Hidalgo, Camila, additional, Crouch, Cara, additional, Yan, Cheung Tsz, additional, Tschuor, Christoph, additional, Shaw, Conrad, additional, Schizas, Dimitrios, additional, Fritche, Dominic, additional, Huda, Fabia Ferdousi, additional, Wells, Gemma, additional, Farrer, Giselle, additional, Kwok, Hiu Tat, additional, Kostakis, Ioannis, additional, Mestre-Costa, Joao, additional, Fan, Ka Hay, additional, Fan, Ka Siu, additional, Fraser, Kyra, additional, Jeilani, Lelia, additional, Pang, Li, additional, Lenti, Lorenzo, additional, Kathirvel, Manikandan, additional, Zachiotis, Marinos, additional, Vailas, Michail, additional, Milan, Michele Mazza, additional, Elnagar, Mohamed, additional, Alradhawi, Mohammad, additional, Dimitrokallis, Nikolaos, additional, Machairas, Nikolaos, additional, Morare, Nolitha, additional, Yeung, Oscar, additional, Khanal, Pragalva, additional, Satish, Pranav, additional, Ghani, Shahi Abdul, additional, Makhdoom, Shahroo, additional, Arulrajan, Sithhipratha, additional, Bogan, Stephanie, additional, Pericleous, Stephanos, additional, Blakemore, Timon, additional, Otti, Vanessa, additional, Lam, Walter, additional, Jackson, Whitney, additional, and Abdi, Zakee, additional

Published
2023
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28. In situ normothermic regional perfusion versus ex situ normothermic machine perfusion in liver transplantation from donation after circulatory death

Author

Mohkam, Kayvan, Nasralla, David, Mergental, Hynek, Muller, Xavier, Butler, Andrew, Jassem, Wayel, Imber, Charles, Monbaliu, Diethard, Perera, M Thamara PR, Laing, Richard W, García-Valdecasas, Juan Carlos, Paul, Andreas, Dondero, Federica, Cauchy, François, Savier, Eric, Scatton, Olivier, Robin, Fabien, Sulpice, Laurent, Bucur, Petru, Salamé, Ephrem, Pittau, Gabriella, Allard, Marc-Antoine, Pradat, Pierre, Rossignol, Guillaume, Mabrut, Jean-Yves, Ploeg, Rutger J, Friend, Peter J, Mirza, Darius F, Lesurtel, Mickaël, Consortium For Organ Preservation In Europe (COPE), Mohkam, Kayvan [0000-0002-9695-0902], Mergental, Hynek [0000-0001-5480-9380], Muller, Xavier [0000-0002-8849-5495], Savier, Eric [0000-0003-4131-2222], Rossignol, Guillaume [0000-0002-9896-4144], Mabrut, Jean-Yves [0000-0002-5701-3588], Lesurtel, Mickaël [0000-0003-2397-4599], and Apollo - University of Cambridge Repository

Subjects
End Stage Liver Disease, Perfusion, Carcinoma, Hepatocellular, Graft Survival, Liver Neoplasms, Humans, Aspartate Aminotransferases, Organ Preservation, Severity of Illness Index, Liver Transplantation
Abstract

In situ normothermic regional perfusion (NRP) and ex situ normothermic machine perfusion (NMP) aim to improve the outcomes of liver transplantation (LT) using controlled donation after circulatory death (cDCD). NRP and NMP have not yet been compared directly. In this international observational study, outcomes of LT performed between 2015 and 2019 for organs procured from cDCD donors subjected to NRP or NMP commenced at the donor center were compared using propensity score matching (PSM). Of the 224 cDCD donations in the NRP cohort that proceeded to asystole, 193 livers were procured, resulting in 157 transplants. In the NMP cohort, perfusion was commenced in all 40 cases and resulted in 34 transplants (use rates: 70% vs. 85% [p = 0.052], respectively). After PSM, 34 NMP liver recipients were matched with 68 NRP liver recipients. The two cohorts were similar for donor functional warm ischemia time (21 min after NRP vs. 20 min after NMP; p = 0.17), UK-Donation After Circulatory Death risk score (5 vs. 5 points; p = 0.38), and laboratory Model for End-Stage Liver Disease scores (12 vs. 12 points; p = 0.83). The incidence of nonanastomotic biliary strictures (1.5% vs. 2.9%; p > 0.99), early allograft dysfunction (20.6% vs. 8.8%; p = 0.13), and 30-day graft loss (4.4% vs. 8.8%; p = 0.40) were similar, although peak posttransplant aspartate aminotransferase levels were higher in the NRP cohort (872 vs. 344 IU/L; p < 0.001). NRP livers were more frequently allocated to recipients suffering from hepatocellular carcinoma (HCC; 60.3% vs. 20.6%; p < 0.001). HCC-censored 2-year graft and patient survival rates were 91.5% versus 88.2% (p = 0.52) and 97.9% versus 94.1% (p = 0.25) after NRP and NMP, respectively. Both perfusion techniques achieved similar outcomes and appeared to match benchmarks expected for donation after brain death livers. This study may inform the design of a definitive trial.

Published
2022

33. Donor-Recipient Body Surface Area Mismatch and the Outcome of Liver Transplantation in the UK.

Author

Kostakis, Ioannis D., Raptis, Dimitri Aristotle, Davidson, Brian R., Iype, Satheesh, Nasralla, David, Imber, Charles, Sharma, Dinesh, Pissanou, Theodora, and Pollok, Joerg Matthias

Subjects
CONFIDENCE intervals, RESEARCH methodology, PATIENTS, GRAFT survival, RETROSPECTIVE studies, TREATMENT effectiveness, BODY surface area, VENOUS thrombosis, COMPARATIVE studies, SURVIVAL analysis (Biometry), DESCRIPTIVE statistics, LIVER transplantation, DATA analysis software, ODDS ratio, LOGISTIC regression analysis, TRANSPLANTATION of organs, tissues, etc., EVALUATION
Abstract

Introduction: Too small or too big liver grafts for recipient's size has detrimental effects on transplant outcomes. Research Questions: The purpose was to correlate donor-recipient body surface area ratio or body surface area index with recipient survival, graft survival, hepatic artery or portal vein, or vena cava thrombosis. High and low body surface area index cut-off points were determined. Design: There were 11,245 adult recipients of first deceased donor whole liver-only grafts performed in the UK from January 2000 until June 2020. The transplants were grouped according to the body surface area index and compared to complications, graft and recipient survival. Results: The body surface area index ranged from 0.491 to 1.691 with a median of 0.988. The body surface area index > 1.3 was associated with a higher rate of portal vein thrombosis within the first 3 months (5.5%). This risk was higher than size-matched transplants (OR: 2.878, 95% CI: 1.292-6.409, P = 0.01). Overall graft survival was worse in transplants with body surface area index ≤ 0.85 (HR: 1.254, 95% CI: 1.051-1.497, P = 0.012) or body surface area index > 1.4 (HR: 3.704, 95% CI: 2.029-6.762, P < 0.001) than those with intermediate values. The graft survival rates were reduced by 2% for cases with body surface area index ≤ 0.85 but were decreased by 20% for cases with body surface area index > 1.4. These findings were confirmed by bootstrap internal validation. No statistically significant differences were detected for hepatic artery thrombosis, occlusion of hepatic veins/inferior vena cava or recipient survival. Conclusions: Donor-recipient size mismatch affects the rates of portal vein thrombosis within the first 3 months and overall graft survival in deceased-donor liver transplants. [ABSTRACT FROM AUTHOR]

Published
2023
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35. Does machine perfusion improve immediate and short‐term outcomes by enhancing graft function and recipient recovery after liver transplantation? A systematic review of the literature, meta‐analysis and expert panel recommendations.

Author

Ramírez‐Del Val, Alejandro, Guarrera, James, Porte, Robert J., Selzner, Markus, Spiro, Michael, Raptis, Dimitri Aristotle, Friend, Peter J., and Nasralla, David

Subjects
LIVER transplantation, KIDNEY transplantation, PERFUSION, ISOLATION perfusion, LENGTH of stay in hospitals
Abstract

Background: Recent evidence supports the use of machine perfusion technologies (MP) for marginal liver grafts. Their effect on enhanced recovery, however, remains uncertain. Objectives: To identify areas in which MP might contribute to an ERAS program and to provide expert panel recommendations. Data sources: Ovid MEDLINE, Embase, Scopus, Google Scholar, and Cochrane Central. Methods: Systematic review and meta‐analysis following PRISMA guidelines and recommendations using the GRADE approach. CRD42021237713 Results: Both hypothermic (HMP) and normothermic (NMP) machine perfusion demonstrated significant benefits in preventing postreperfusion syndrome (PRS) (HMP OR.33,.15‐.75 CI; NMP OR.51,.29‐.90 CI) and early allograft dysfunction (EAD) (HMP OR.51,.35‐.75 CI; NMP OR.66,.45‐.97 CI), while shortening LOS (HMP MD ‐3.9; NMP MD ‐12.41). Only NMP showed a significant decrease in the length of ICU stay (L‐ICU) (MD ‐7.07, ‐8.76; ‐5.38 CI), while only HMP diminishes the likelihood of major complications. Normothermic regional perfusion (NRP) reduces EAD (OR.52,.38–.70 CI) and primary nonfunction (PNF) (OR.51,.27‐.98 CI) without effect on L‐ICU and LOS. Conclusions: The use of HMP decreases PRS and EAD, specifically for marginal grafts. This is supported by a shorter LOS and a lower rate of major postoperative complications (QOE; moderate | Recommendation; Strong). NMP reduces the incidence of PRS and EAD with associated shortening in L‐ICU for both DBD and DCD grafts (QOE; moderate | Recommendation; High) This technology also shortens the length of hospital stay (QOE; low | Recommendation; Strong). NRP decreases the likelihood of EAD (QOE; moderate) and the risk of PNF (QOE; low) when compared to both DBD and SRR‐DCD grafts preserved in SCS. (Recommendation; Strong). [ABSTRACT FROM AUTHOR]

Published
2022
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37. HETEROGENEOUS INDICATIONS AND THE NEED FOR VIABILITY ASSESSMENT: RESULTS OF AN INTERNATIONAL SURVEY ON MACHINE PERFUSION IN LIVER TRANSPLANTATION

Author

Patrono, Damiano, Cussa, Davide, Rigo, Federica, Angelico, Roberta, Bellini, Maria Irene, Riani, Eliano Bonaccorsi, Bruggenwirth, Isabel, Czigany, Zoltan, Carlis, Riccardo, Meijer, Vincent E., Dondossola, Daniele, Eshmuminov, Dilmurodjon, Ghinolfi, Davide, Hessheimer, Amelia, Kollmann, Dagmar, Lai, Quirino, Lurje, Georg, Manzia, Tommaso M., Merhabi, Ari, Melandro, Fabio, Nasralla, David, Nickkholgh, Arash, Pagano, Duilio, Rayar, Michel, Weissenbacher, Annemarie, Avolio, Alfonso W., Paolo De Simone, Fondevila, Costantino, Jassem, Wayel, Macconmara, Malcolm, Porte, Robert J., Selzner, Markus, Spada, Marco, and Romagnoli, Renato

Published
2021

38. Coagulation Factors Accumulate During Normothermic Liver Machine Perfusion Regardless of Donor Type and Severity of Ischemic Injury.

Author

UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service d'anatomie pathologique, Gilbo, Nicholas, Jacquemin, Marc, Nasralla, David, Lazzaro, Silvia, Libbrecht, Louis, Lavend'homme, Renaud, Peerlinck, Kathelijne, Ploeg, Rutger J, Friend, Peter J, Pirenne, Jacques, Monbaliu, Diethard, Jochmans, Ina, UCL - SSS/IREC/SLUC - Pôle St.-Luc, UCL - (SLuc) Service d'anatomie pathologique, Gilbo, Nicholas, Jacquemin, Marc, Nasralla, David, Lazzaro, Silvia, Libbrecht, Louis, Lavend'homme, Renaud, Peerlinck, Kathelijne, Ploeg, Rutger J, Friend, Peter J, Pirenne, Jacques, Monbaliu, Diethard, and Jochmans, Ina

Abstract

BACKGROUND: Coagulation factors may inform on liver function during normothermic machine perfusion (NMP). We investigated whether graft ischemic injury impairs the accumulation of (anti)coagulation factors during NMP of porcine and human livers. METHODS: Dynamics of FV, FVII, FVIII, FIX, FX during NMP and their correlation with graft injury was investigated in porcine livers with minimal (no warm ischemia, n=5) or severe injury (60 minutes warm ischemia, n=5). Next, FV, FVIII, FIX, fibrinogen, and antithrombin were measured in 35 matched human liver NMPs from the COPE trial. Correlation of these factors with outcomes was explored. Livers were categorized in 4 groups depending on donor type and post-transplant peak aspartate aminotransferase (AST) as surrogate of minimal (peak<500 IU/L) or moderate injury (peak>1000 IU/L). RESULTS: Factor concentrations increased significantly during NMP regardless of severity of injury. In porcine livers, factor concentrations were 2-6 fold lower in severely injured grafts (all p<0.05). All factors negatively correlated with AST (coefficient range -0.50 to -0.93; all p<0.05) and lactate (range -0.51 to -0.67; all p<0.05). In human livers, no difference in factor accumulation rates and no correlation with other markers was observed. One graft with primary nonfunction had low rate of factor accumulation. CONCLUSION: (Anti)coagulation factors accumulate during NMP regardless of donor type and severity of injury. In pigs, severe ischemic injury resulted in significantly lower factor concentrations. In human livers with life-sustaining function, they do not correlate with hepatic injury. Whether low concentrations predict nonfunction in high-risk livers with severe injury requires further investigation.

Published
2021

40. Multicenter validation of the liver graft assessment following transplantation (L-GrAFT) score for assessment of early allograft dysfunction

Author

Agopian, Vatche G., primary, Markovic, Daniela, additional, Klintmalm, Goran B., additional, Saracino, Giovanna, additional, Chapman, William C., additional, Vachharajani, Neeta, additional, Florman, Sander S., additional, Tabrizian, Parissa, additional, Haydel, Brandy, additional, Nasralla, David, additional, Friend, Peter J., additional, Boteon, Yuri L., additional, Ploeg, Rutger, additional, Harlander-Locke, Michael P., additional, Xia, Victor, additional, DiNorcia, Joseph, additional, Kaldas, Fady M., additional, Yersiz, Hasan, additional, Farmer, Douglas G., additional, and Busuttil, Ronald W., additional

Published
2021
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41. Coagulation Factors Accumulate During Normothermic Liver Machine Perfusion Regardless of Donor Type and Severity of Ischemic Injury

Author

Gilbo, Nicholas, primary, Jacquemin, Marc, additional, Nasralla, David, additional, Lazzaro, Silvia, additional, Libbrecht, Louis, additional, Lavend’homme, Renaud, additional, Peerlinck, Kathelijne, additional, Ploeg, Rutger J., additional, Friend, Peter J., additional, Pirenne, Jacques, additional, Monbaliu, Diethard, additional, and Jochmans, Ina, additional

Published
2021
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42. Global management of a common, underrated surgical task during the COVID-19 pandemic: Gallstone disease - An international survery

Author

Manzia, Tommaso Maria, Angelico, Roberta, Parente, Alessandro, Muiesan, Paolo, Tisone, Giuseppe, Al Alawy, Yousef, Arif, Abdul Jabba, Attia, Magdy, Bhati, Chandra, Battula R, Narendra, Bonney, Glenn Kunnath, Brooke-Smith, Mark, Derosas, Carlos, De Liguori Carino, Nicola, Ferretti, Stefano, Fiorani, Cristina, Gherardi, Dario, Hegab, Bassem, Hussain, Zaki, Ielpo, Benedetto, Iesari, Samuele, Lai, Quirino, Lainas, Panagiotis, Lauterio, Andrea, Lazzaro, Alessandra, Marudanayagam, Ravi, Nasralla, David, Nicolini, Daniele, Orlando, Giuseppe, Patrono, Damiano, et al, University of Zurich, and Angelico, Roberta

Subjects
610 Medicine & health, 10217 Clinic for Visceral and Transplantation Surgery, 2746 Surgery, COVID
Published
2020

45. Global management of a common, underrated surgical task during the COVID-19 pandemic: Gallstone disease - An international survery

Author

Manzia, Tommaso Maria, primary, Angelico, Roberta, additional, Parente, Alessandro, additional, Muiesan, Paolo, additional, Tisone, Giuseppe, additional, Al Alawy, Yousef, additional, Arif, Abdul Jabba, additional, Attia, Magdy, additional, Bhati, Chandra, additional, Battula R, Narendra, additional, Bonney, Glenn Kunnath, additional, Brooke-Smith, Mark, additional, Derosas, Carlos, additional, De Liguori Carino, Nicola, additional, Ferretti, Stefano, additional, Fiorani, Cristina, additional, Gherardi, Dario, additional, Hegab, Bassem, additional, Hussain, Zaki, additional, Ielpo, Benedetto, additional, Iesari, Samuele, additional, Lai, Quirino, additional, Lainas, Panagiotis, additional, Lauterio, Andrea, additional, Lazzaro, Alessandra, additional, Marudanayagam, Ravi, additional, Nasralla, David, additional, Nicolini, Daniele, additional, Orlando, Giuseppe, additional, Patrono, Damiano, additional, Pitchaimuthu, Maheswaran, additional, Polak, Wojciech, additional, Quinto, Alberto Marcacuzco, additional, Rai, Rakesh, additional, Scalera, Irene, additional, Schlegel, Andrea, additional, Shanmugam, Vivek, additional, Vitale, Alessandro, additional, Widmer, Jeannette, additional, and Yannick, Deswysen, additional

Published
2020
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46. Longevity and replenishment of human liver-resident memory T cells and mononuclear phagocytes

Author

Pallett, Laura J., primary, Burton, Alice R., additional, Amin, Oliver E., additional, Rodriguez-Tajes, Sergio, additional, Patel, Amit A., additional, Zakeri, Nekisa, additional, Jeffery-Smith, Anna, additional, Swadling, Leo, additional, Schmidt, Nathalie M., additional, Baiges, Anna, additional, Gander, Amir, additional, Yu, Dominic, additional, Nasralla, David, additional, Froghi, Farid, additional, Iype, Satheesh, additional, Davidson, Brian R., additional, Thorburn, Douglas, additional, Yona, Simon, additional, Forns, Xavier, additional, and Maini, Mala K., additional

Published
2020
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50. A multicentre randomised controlled trial to compare the efficacy of ex-vivo normothermic machine perfusion with static cold storage in human liver transplantation

Author

Nasralla, David, primary, Nasralla, David, additional, Akhtar, Mohammed Zeeshan, additional, Bradley, Ally, additional, Butler, Andrew, additional, Chiocchia, Virginia, additional, Dutton, Susan, additional, García-Valdecasas, Juan Carlos, additional, Imber, Charles, additional, Jassem, Wayel, additional, Knight, Simon, additional, Mergental, Hynek, additional, Paul, Andreas, additional, Pirenne, Jacques, additional, Ploeg, Rutger, additional, Coussios, Constantin C, additional, and Friend, Peter J, additional

Published
2018
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