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Purpose: Today, due to increasing significance importance using virtual reality technology, are no longer constrained by have time location when it comes to in their shopping experience. Today, with the availability of virtual reality devices, an increasing number of retailers are utilizing this interactive 3D technology to visualize their products. Simulated experiences create both real and unreal situations, eliciting a positive response from customers and influencing their purchase intentions. In the field of virtual reality adoption, numerous studies have explored the influence of theories like diffusion of innovation and use and gratification on customers' behavioral intention to use virtual reality, particularly in the tourism sector. However, these studies have overlooked the impact of significant negative factors such as perceived cost, perceived physical risk, and perceived complexity. The present study aims to investigate the factors that influence customers' behavioral intention to use virtual reality. This will be based on the theories of innovation diffusion, the theory of uses and pleasures, and the perceived value among individuals who shop through virtual networks. Method: The present study was conducted with a practical purpose and utilized a descriptive-survey method. The statistical population of the study comprised individuals who make purchases through online networks, with a focus on products that require inspection before purchase. In this study, a statistical sample of 250 has been determined due to the infinite size of the statistical population and by utilizing the relationship between Jackson and Klein. Finally, 250 people have been identified as the research sample using a non-random sampling method. In this study, a questionnaire tool was utilized to gather information, and its validity was confirmed and examined by professors. Reliability was measured using Cronbach's alpha. The obtained alpha is 78%, and it has been approved. To analyze the data, SPSS and Amos software were used, employing statistical methods such as Kolmogorov-Smirnov, t-tests, regression analysis, and structural equation modeling. Findings: The research results confirmed the presented conceptual model. The structural equations also indicated that innovation diffusion, use and gratification theories, and perceived value have a positive and significant relationship with customers' behavioral intention to use virtual reality. Based on the results obtained from the conceptual model, it is evident that use and gratification have the most significant positive impact on mental comfort, with a value of 0.57. Conversely, among the negative relationships identified, perceived complexity has the most substantial negative effect on perceived value, with a value of -0.62. Furthermore, among the variables influencing behavioral intention, perceived value has the most significant impact on behavioral intention. Conclusion: The results indicate that the customer's perceived value has the most significant impact on their intention to use virtual reality technology. In this context, the greater the extent to which individuals believe that virtual reality technology can fulfill their requirements, the more probable it is that they will opt for this technology. When the perceived value of this technology surpasses customers' expectations and they realize that they receive greater value from the virtual experience compared to the cost, time, and effort invested, they will be more inclined to utilize this technology. Based on this result, it is suggested that the complexity of virtual reality technology be reduced, and all types of customer costs, including tangible and intangible costs, as well as the physical risk of the product, should be considered in the design and use of this technology to enhance the perceived value of customers toward this technology. To ensure a reliable experience, it is recommended to implement measures such as providing online support to promptly address customer inquiries and resolving issues to enhance customer trust and improve their shopping experience.

Enterococci are among Gram-positive cocci and are common inhabitants of the human gastrointestinal tract and enough potent to cause serious infections such as bacteremia, urinary tract infections (UTIs) and endocarditis. Enterococci are not generally considered as highly infectious bacterium. However, the main reason for treatment failure in enterococcal infections is acquired resistance to glycopeptide antibiotics, specifically vancomycin. Most enterococcal infections in human such as gastroenteritis, intestinal infections, and endocarditis have been caused by E. faecalis and E. facieum. They are holding the second place of most frequent cause of hospital infections since 1990. In present study gyrA S83R polymorphism rate in vancomycin resistant Enterococcus faecium isolated from environment, food industries, and hospitals of Tehran were examined by ARMS-PCR technique. DNA was extracted from the bacterial colonies using standard column method, after separating the samples into two groups of antibiotic resistant and antibiotic susceptible by antibiogram test. A fragment of gyrA gene was amplified using PCR method to investigate point mutation of S83R position. ARMS-PCR technique was applied to detect the presence or absence of mutation using a set of specified primers which can be annealed when the mutation is present. The results were statistically analyzed by chi-square test (p < 0.05) using SPSS 19th version. The results showed that there was a significant correlation between the presences of S83R polymorphism with vancomycin resistance trait in Entrococcus faecium. Therefore, this technique could be used as a diagnostic tool to detect vancomycin resistance cases of E. faecium in patients and environment. HIGHLIGHTS •There is a strong association between the presence of point mutation at the position of Ser83 and vancomycin resistant phenotype. •Resistance in Enterococcus spp. is highly mediated by mutations in gyrA gene which plays a major role in interaction with vancomycin. •Vancomycin is the only drug that can be consistently relied on for the treatment of infections caused by multidrug resistant enterococci. •VRE has presented a serious challenge for the Iranian medical community.

Increased population of elderly people has led scholars and specialists to focus on the importance of paying attention to the health of the elderly and to provide the necessary facilities for special services in this area. Some important factors that determine the quality of life of the elderly are differentiation and frustration tolerance. Therefore, the purpose of this study is to predict psychological resilience based on the degree of differentiation and frustration tolerance of the elderly. The method of this research was descriptive correlational. The statistical population of the study included all elderly people over 60 years old covered by the Social Security Department of Kermanshah. A sample of 195 elderly people was selected using convenient sampling method. The tools used in this research were Ahwaz Psychological Resilience Questionnaire, Skowron and Friedlander’s The Differentiation of Self Inventory, and Harrington’s Frustration Discomfort Scale. Using Pearson correlation method and multivariate regression model, the findings shows that there is a positive and significant relationship between differentiation and psychological resilience of elderly people. There is a significant positive correlation between frustration tolerance and psychological resilience. The variables of frustration tolerance, differentiation in the context of interaction with others, and differentiation in the context of emotional responsiveness, respectively, predict the psychological resilience of the elderly. Therefore, it can be said that if problems that cause despair in the elderly are not resolved in a reasonable and timely manner, they cause many discomforts and tensions that result in person's personality and behavior disorder and, if they progress, leads to mental illness.

Hepatocellular carcinoma (HCC) is a severe malignant liver cancer with a poor prognosis and a high mortality rate. This carcinoma is a multistage process that begins with chronic hepatitis and progresses to cirrhosis, dysplastic nodules, and eventually HCC. However, the exact molecular etiology remains unclear. MicroRNAs (miRs) are small non-coding RNAs that modulate the expression of numerous genes. These molecules have become significant participants in several functions, including cell proliferation, differentiation, development, and tumorrelated properties. They have a pivotal role in carcinogenesis as oncogenes or tumor suppressor genes. Furthermore, some investigations have shown that particular miRs might be used as predictive or diagnostic markers and therapeutic targets in HCC therapy. This review study summarizes the current level of knowledge on the role of miRs in the initiation and progression of HCC. [ABSTRACT FROM AUTHOR]