147,666 results on '"Nash, A"'
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2. Arab Americans in Film: From Hollywood and Egyptian Stereotypes to Self-Representation by Waleed F. Mahdi (review)
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Nash, Amin
- Published
- 2022
3. Evolution of the Archean Atmosphere
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Goldblatt, Colin, Eager-Nash, Jake K., and Horne, Julia E.
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Astrophysics - Earth and Planetary Astrophysics ,Physics - Atmospheric and Oceanic Physics - Abstract
Archean atmospheric evolution is the transition from an abiological atmosphere, to an atmosphere for which the composition and therefore climate is highly altered by life. We review the key processes and transitions in this evolution., Comment: 16 pages, 1 figure. Accepted for publication as: Colin Goldblatt, Jake K. Eager-Nash, and Julia E. Horne (in press) "Evolution of the Archean Atmosphere", in: "The Archean Earth" (ed.: Martin Homan, Paul Mason, Richard Ernst, Timothy Lyons, Christoph Heubeck, Dominic Papineau, Eva Stueeken, Rajat Mazumder, Alexander Webb, Wladyslaw Altermann), Elsevier
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- 2024
4. Play Me Something Icy: Practical Challenges, Explainability and the Semantic Gap in Generative AI Music
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Allison, Jesse, Farrar, Drew, Nash, Treya, Román, Carlos, Weeks, Morgan, and Ju, Fiona Xue
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Computer Science - Sound ,Computer Science - Artificial Intelligence ,Electrical Engineering and Systems Science - Audio and Speech Processing - Abstract
This pictorial aims to critically consider the nature of text-to-audio and text-to-music generative tools in the context of explainable AI. As a group of experimental musicians and researchers, we are enthusiastic about the creative potential of these tools and have sought to understand and evaluate them from perspectives of prompt creation, control, usability, understandability, explainability of the AI process, and overall aesthetic effectiveness of the results. One of the challenges we have identified that is not explicitly addressed by these tools is the inherent semantic gap in using text-based tools to describe something as abstract as music. Other gaps include explainability vs. useability, and user control and input vs. the human creative process. The aim of this pictorial is to raise questions for discussion and make a few general suggestions on the kinds of improvements we would like to see in generative AI music tools., Comment: In Proceedings of Explainable AI for the Arts Workshop 2024 (XAIxArts 2024) arXiv:2406.14485
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- 2024
5. Decentralized Health Intelligence Network (DHIN)
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Nash, Abraham
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Computer Science - Cryptography and Security ,Computer Science - Artificial Intelligence ,Computer Science - Computers and Society ,Computer Science - Distributed, Parallel, and Cluster Computing ,Computer Science - Emerging Technologies - Abstract
Decentralized Health Intelligence Network (DHIN) extends the Decentralized Intelligence Network (DIN) framework to address challenges in healthcare data sovereignty and AI utilization. Building upon DIN's core principles, DHIN introduces healthcare-specific components to tackle data fragmentation across providers and institutions, establishing a sovereign architecture for healthcare provision. It facilitates effective AI utilization by overcoming barriers to accessing diverse health data sources. This comprehensive framework leverages: 1) self-sovereign identity architecture coupled with a personal health record (PHR), extending DIN's personal data stores concept to ensure health data sovereignty; 2) a scalable federated learning (FL) protocol implemented on a public blockchain for decentralized AI training in healthcare, tailored for medical data; and 3) a scalable, trustless rewards mechanism adapted from DIN to incentivize participation in healthcare AI development. DHIN operates on a public blockchain with an immutable record, ensuring that no entity can control access to health data or determine financial benefits. It supports effective AI training while allowing patients to maintain control over their health data, benefit financially, and contribute to a decentralized ecosystem. Unique to DHIN, patients receive rewards in digital wallets as an incentive to opt into the FL protocol, with a long-term roadmap to fund decentralized insurance solutions. This approach introduces a novel, self-financed healthcare model that adapts to individual needs, complements existing systems, and redefines universal coverage, showcasing how DIN principles can transform healthcare data management and AI utilization while empowering patients., Comment: 13 pages, 6 figures
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- 2024
6. Remembering Peter Hudson
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Nash, Andrew
- Published
- 2020
- Full Text
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7. Kitten of the harbour
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Nash, Addi and Chen, Yanfei
- Published
- 2023
8. National Survey of Legal Clinics Housed by the Department of Veterans Affairs to Inform Partnerships with Health and Community Services
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Timko, Christine, Taylor, Emmeline, Nash, Amia, Blonigen, Daniel, Smelson, David, Tsai, Jack, and Finlay, Andrea K
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- 2020
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9. 'Putting Science into Action': A Case Study of How an Educational Intermediary Organization Synthesizes and Translates Research Evidence for Practice
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Ashley Metzger, Addison Duane, Amia Nash, and Valerie Shapiro
- Abstract
Background: Knowledge brokering by intermediary organizations includes knowledge distillation processes (e.g., synthesis, translation). Aims and objectives: This article explores how an educational intermediary performs research distillation when creating virtual knowledge reservoirs for educators. Methods: The authors use qualitative data from semi-structured interviews, coded to consensus, and thematically analyzed. Findings: During synthesis, intermediaries apply a "research lens" to evaluate the credibility of the evidence. During translation, they rely on their experience as educators to share evidence in a non-academic voice and generate "turnkey" strategies. Discussion and conclusion: The article considers the knowledge brokering pipeline fallacy and examines the potential of ongoing processes for improving the effectiveness of intermediaries with the aim of diminishing research-practice and research-policy gaps in education.
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- 2024
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10. Making Summer Count: Youths' Perceptions of Meaningfulness and Future Orientation in Summer Youth Employment Contexts
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Denise Jones, Zaida Pearson, Deanna C. E. Sinex, Jeremiah Nash, Aiwen Chen, and Dennis F. Jones
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The current study explores the efforts of one summer youth employment program to provide students with meaningful work experiences and the participants' perceptions of the meaningfulness of their work and its effect on their future orientation. Most of the students in the study were under the age of 18. The Youth Enrichment Services (YES) Summer Learn and Earn program provides students with summer enrichment, their first work experience, and meaningful opportunities to engage with work. The purpose of this study was to better understand YES participants' perceptions of the meaningfulness of their summer work experiences. A secondary goal was to investigate how participants' work experiences related to their future orientations. YES is a community-based organization in Pittsburgh that gives socially and economically disadvantaged youth opportunities to achieve success through its academic enrichment, alternative to detention, peer mentor certification, life skills, cultural enrichment, diversity awareness, workforce readiness, and wellness-based programming.
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- 2024
11. Residential Move during COVID-19 Pandemic and Psychological Health among College Students: The Role of Perceived Social Support
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Esther Lamidi, Osasohan Agbonlahor, Larry Gibbs, and Sue P. Nash
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Research has widely documented the high stress levels posed to college students by the Coronavirus Disease 2019 (COVID-19). However, the role of social support in mitigating the mental health impacts of stressors like residential instability among college students is less well-researched. Using data from a multi-campus online survey of college students' experiences during the COVID-19 pandemic (n = 2,486), this study examines the role of social support in the association between residential move during COVID-19 pandemic and college students' reports of depressive symptoms and anxiety. We tested whether perceived social support was more significantly related to depressive symptoms among students who moved in response to COVID-19. The results show significantly higher levels of depressive symptoms and higher prevalence rates of severe anxiety among college students with COVID-19-related move relative to those who did not move during the pandemic. Irrespective of their residential status, college students who received less support than needed during the pandemic had significantly higher levels of depressive symptoms and higher odds of severe anxiety. The findings add to the existing studies showing how the COVID-19 pandemic compounds the problems of depression and anxiety among college students, particularly those experiencing residential instability and with limited social support.
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- 2024
12. The Impact of Virtual or Blended Learning on Sense of Belonging in First-Year Undergraduate Health Sciences Students Enrolled in an Inquiry-Based Course
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Michael Wong, Shahad Al-Saqqar, Jennifer Nash, Ali Al-Humuzi, Mark Dottori, and Margaret Secord
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Literature suggests post-secondary students feel disengaged and socially isolated while learning virtually, especially during the COVID-19 pandemic. Here we explored whether a sense of belonging is differentially achieved in an inquiry-based course between two different delivery formats: virtual and blended (combination of virtual and in-person). Our primary measurement instrument was a modified version of the 26-item Sense of Belonging-Revised Scale, which we distributed to all first-year Bachelor of Health Sciences (BHSc) (Honours) Program students enrolled in an Inquiry course at McMaster University during the 2021-2022 school year. Data analyses revealed no statistically significant difference between the two groups across the four subscales of the Sense of Belonging-Revised Scale: perceived peer support, perceived classroom comfort, perceived isolation, and perceived faculty support. As promoting community is a core skill in our Inquiry course, this may have reduced the perceived difference between the two groups. Future directions include exploring facilitators' perceptions and experiences across course delivery formats.
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- 2024
13. Responding to remote, rural and regional tertiary education needs: A conversation between the Australian Regional Education Commissioner and the Scottish Commissioner for fair access
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McKendrick, John H, Lasselle, Laurence, Nash, Fiona, Fuqua, Melyssa, Guenther, John, and Hall, Carmel
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- 2024
14. What Are the Autism Research Priorities of Autistic Adults in Scotland?
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Eilidh Cage, Catherine J. Crompton, Sarah Dantas, Khiah Strachan, Rachel Birch, Mark Robinson, Stasa Morgan-Appel, Charlie MacKenzie-Nash, Aaron Gallagher, and Monique Botha
- Abstract
Studies investigating autistic community research priorities indicate a mismatch between what autism research focuses on and what autistic people want to see researched. Furthermore, there has not been a research priority-setting exercise specifically with autistic people in Scotland, where there are unique cultural, political and social contexts. Using a community-based participatory design, we aimed to identify the research priorities of autistic adults living in Scotland. Autistic and non-autistic researchers designed and conducted a survey where 225 autistic adults rated and ranked research topics in order of importance and provided qualitative feedback on issues and questions important to them. The top five research priorities were mental health/well-being, identification and diagnosis of autistic people, support services, knowledge and attitudes towards autistic people and issues impacting autistic women. There were differences in priorities according to different intersections of identity, and qualitative responses indicated a desire for research to focus on support and understanding. The bottom three priorities concerned genetics, treatments and interventions and causes. These findings emphasise the need to address the gap between what autism research focuses on and the everyday lives of autistic people.
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- 2024
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15. Assessing Children's Health Literacy: A Curricular Approach
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Claire Otten, Nenagh Kemp, Vaughan Cruickshank, Louisa Peralta, Melanie Hawkins, and Rose Nash
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Objectives: Increasing childhood health literacy (HL) is a crucial means of improving health outcomes and reducing preventable deaths globally. Understanding how to best support children's HL development in schools is essential. However, identifying pedagogical strategies that develop children's HL relies on a fit-for-purpose measure. Currently, no universally accepted approach for measuring HL among children exists. The purpose of this paper was to propose and discuss how a curricular approach to assessing children's HL could provide a means to overcoming the challenges with existing children HL measures. Design/Methods: The discussion is framed by the key components of assessment -- outcome of interest, and collection, analysis and interpretation of data -- and is underpinned by contemporary HL and educational research. Setting: The Australian Curriculum is used to discuss the approach in practice. Results: A curricular approach to HL assessment suggests that HL assessment may work best when it is relevant to the child and their context, is integrated with other areas of the curriculum, allows children to demonstrate a wide range of HL skills and contains an element of open-endedness. Measurement could be guided by a rubric (underpinned by a taxonomy), and interpretation of scores consistently aligned with the learning intentions outlined in the curriculum. Conclusion: A curricular approach provides a contextually adaptive framework from which HL assessment tools for children can be developed
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- 2024
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16. Neutron imaging of high-temperature Na-Zn Cells: implications for cell design and fabrication
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Nash, William, Sarma, Martins, Lappan, Tobias, Trtik, Pavel, Solem, Catherine K. W., Wang, Zhaohui, Beltrán, Alberto, Weber, Norbert, and Weier, Tom
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Condensed Matter - Materials Science ,76D99 - Abstract
Electrochemical cells employing Sodium (Na) and Zinc (Zn) electrodes and a chloride salt electrolyte have been imaged by neutron radiography during cycling. The use of such abundant raw materials confers a very low energy-normalised cost to the Na-Zn system, but its operation requires them to be entirely molten, and therefore to be operated at 600 {\deg}C. To suppress the self-discharge that results from this all-molten configuration, porous ceramic diaphragms are used to partition the electrolyte and thereby impede the movement of the Zn2+ ions responsible towards the Na electrode. Neutron images reveal large gas bubbles trapped beneath these diaphragms, formed during the cell fabrication process due to the large volume change that accompanies melting/solidifying of the electrolyte. Cycling data confirm that these bubbles interfere with cell operation by substantially increasing ohmic resistance. They indicate the need for either a new diaphragm design, or a cell fabrication process that prevents their formation in the first instance., Comment: 8 pages, 3 figures
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- 2024
17. Decentralized Intelligence Network (DIN)
- Author
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Nash, Abraham
- Subjects
Computer Science - Cryptography and Security ,Computer Science - Computers and Society ,Computer Science - Distributed, Parallel, and Cluster Computing ,Computer Science - Emerging Technologies ,Computer Science - Machine Learning - Abstract
Decentralized Intelligence Network (DIN) is a theoretical framework designed to address challenges in AI development, particularly focusing on data fragmentation and siloing issues. It facilitates effective AI training within sovereign data networks by overcoming barriers to accessing diverse data sources, leveraging: 1) personal data stores to ensure data sovereignty, where data remains securely within Participants' control; 2) a scalable federated learning protocol implemented on a public blockchain for decentralized AI training, where only model parameter updates are shared, keeping data within the personal data stores; and 3) a scalable, trustless cryptographic rewards mechanism on a public blockchain to incentivize participation and ensure fair reward distribution through a decentralized auditing protocol. This approach guarantees that no entity can prevent or control access to training data or influence financial benefits, as coordination and reward distribution are managed on the public blockchain with an immutable record. The framework supports effective AI training by allowing Participants to maintain control over their data, benefit financially, and contribute to a decentralized, scalable ecosystem that leverages collective AI to develop beneficial algorithms., Comment: 16 pages, 1 figure. DIN was presented by the author as a speaker at the Summit on Responsible Decentralized Intelligence - Future of Decentralization and AI, hosted by Berkeley RDI on August 6, 2024, at the Verizon Center, Cornell Tech Campus, Roosevelt Island, NYC
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- 2024
18. The PLATO Mission
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Rauer, Heike, Aerts, Conny, Cabrera, Juan, Deleuil, Magali, Erikson, Anders, Gizon, Laurent, Goupil, Mariejo, Heras, Ana, Lorenzo-Alvarez, Jose, Marliani, Filippo, Martin-Garcia, Cesar, Mas-Hesse, J. Miguel, O'Rourke, Laurence, Osborn, Hugh, Pagano, Isabella, Piotto, Giampaolo, Pollacco, Don, Ragazzoni, Roberto, Ramsay, Gavin, Udry, Stéphane, Appourchaux, Thierry, Benz, Willy, Brandeker, Alexis, Güdel, Manuel, Janot-Pacheco, Eduardo, Kabath, Petr, Kjeldsen, Hans, Min, Michiel, Santos, Nuno, Smith, Alan, Suarez, Juan-Carlos, Werner, Stephanie C., Aboudan, Alessio, Abreu, Manuel, Acuña, Lorena, Adams, Moritz, Adibekyan, Vardan, Affer, Laura, Agneray, François, Agnor, Craig, Børsen-Koch, Victor Aguirre, Ahmed, Saad, Aigrain, Suzanne, Al-Bahlawan, Ashraf, Gil, M de los Angeles Alcacera, Alei, Eleonora, Alencar, Silvia, Alexander, Richard, Alfonso-Garzón, Julia, Alibert, Yann, Prieto, Carlos Allende, Almeida, Leonardo, Sobrino, Roi Alonso, Altavilla, Giuseppe, Althaus, Christian, Trujillo, Luis Alonso Alvarez, Amarsi, Anish, Eiff, Matthias Ammler-von, Amôres, Eduardo, Andrade, Laerte, Antoniadis-Karnavas, Alexandros, António, Carlos, del Moral, Beatriz Aparicio, Appolloni, Matteo, Arena, Claudio, Armstrong, David, Aliaga, Jose Aroca, Asplund, Martin, Audenaert, Jeroen, Auricchio, Natalia, Avelino, Pedro, Baeke, Ann, Baillié, Kevin, Balado, Ana, Balestra, Andrea, Ball, Warrick, Ballans, Herve, Ballot, Jerome, Barban, Caroline, Barbary, Gaële, Barbieri, Mauro, Forteza, Sebastià Barceló, Barker, Adrian, Barklem, Paul, Barnes, Sydney, Navascues, David Barrado, Barragan, Oscar, Baruteau, Clément, Basu, Sarbani, Baudin, Frederic, Baumeister, Philipp, Bayliss, Daniel, Bazot, Michael, Beck, Paul G., Bedding, Tim, Belkacem, Kevin, Bellinger, Earl, Benatti, Serena, Benomar, Othman, Bérard, Diane, Bergemann, Maria, Bergomi, Maria, Bernardo, Pierre, Biazzo, Katia, Bignamini, Andrea, Bigot, Lionel, Billot, Nicolas, Binet, Martin, Biondi, David, Biondi, Federico, Birch, Aaron C., Bitsch, Bertram, Ceballos, Paz Victoria Bluhm, Bódi, Attila, Bognár, Zsófia, Boisse, Isabelle, Bolmont, Emeline, Bonanno, Alfio, Bonavita, Mariangela, Bonfanti, Andrea, Bonfils, Xavier, Bonito, Rosaria, Bonomo, Aldo Stefano, Börner, Anko, Saikia, Sudeshna Boro, Martín, Elisa Borreguero, Borsa, Francesco, Borsato, Luca, Bossini, Diego, Bouchy, Francois, Boué, Gwenaël, Boufleur, Rodrigo, Boumier, Patrick, Bourrier, Vincent, Bowman, Dominic M., Bozzo, Enrico, Bradley, Louisa, Bray, John, Bressan, Alessandro, Breton, Sylvain, Brienza, Daniele, Brito, Ana, Brogi, Matteo, Brown, Beverly, Brown, David, Brun, Allan Sacha, Bruno, Giovanni, Bruns, Michael, Buchhave, Lars A., Bugnet, Lisa, Buldgen, Gaël, Burgess, Patrick, Busatta, Andrea, Busso, Giorgia, Buzasi, Derek, Caballero, José A., Cabral, Alexandre, Calderone, Flavia, Cameron, Robert, Cameron, Andrew, Campante, Tiago, Martins, Bruno Leonardo Canto, Cara, Christophe, Carone, Ludmila, Carrasco, Josep Manel, Casagrande, Luca, Casewell, Sarah L., Cassisi, Santi, Castellani, Marco, Castro, Matthieu, Catala, Claude, Fernández, Irene Catalán, Catelan, Márcio, Cegla, Heather, Cerruti, Chiara, Cessa, Virginie, Chadid, Merieme, Chaplin, William, Charpinet, Stephane, Chiappini, Cristina, Chiarucci, Simone, Chiavassa, Andrea, Chinellato, Simonetta, Chirulli, Giovanni, Christensen-Dalsgaard, Jorgen, Church, Ross, Claret, Antonio, Clarke, Cathie, Claudi, Riccardo, Clermont, Lionel, Coelho, Hugo, Coelho, Joao, Cogato, Fabrizio, Colomé, Josep, Condamin, Mathieu, Conseil, Simon, Corbard, Thierry, Correia, Alexandre C. M., Corsaro, Enrico, Cosentino, Rosario, Costes, Jean, Cottinelli, Andrea, Covone, Giovanni, Creevey, Orlagh L., Crida, Aurelien, Csizmadia, Szilard, Cunha, Margarida, Curry, Patrick, da Costa, Jefferson, da Silva, Francys, Dalal, Shweta, Damasso, Mario, Damiani, Cilia, Damiani, Francesco, Chagas, Maria Liduina das, Davies, Melvyn, Davies, Guy, Davies, Ben, Davison, Gary, de Almeida, Leandro, de Angeli, Francesca, de Barros, Susana Cristina Cabral, Leão, Izan de Castro, de Freitas, Daniel Brito, de Freitas, Marcia Cristina, De Martino, Domitilla, de Medeiros, José Renan, de Paula, Luiz Alberto, de Plaa, Jelle, De Ridder, Joris, Deal, Morgan, Decin, Leen, Deeg, Hans, Degl'Innocenti, Scilla, Deheuvels, Sebastien, del Burgo, Carlos, Del Sordo, Fabio, Delgado-Mena, Elisa, Demangeon, Olivier, Denk, Tilmann, Derekas, Aliz, Desidera, Silvano, Dexet, Marc, Di Criscienzo, Marcella, Di Giorgio, Anna Maria, Di Mauro, Maria Pia, Rial, Federico Jose Diaz, Díaz-García, José-Javier, Dima, Marco, Dinuzzi, Giacomo, Dionatos, Odysseas, Distefano, Elisa, Nascimento Jr., Jose-Dias do, Domingo, Albert, D'Orazi, Valentina, Dorn, Caroline, Doyle, Lauren, Duarte, Elena, Ducellier, Florent, Dumaye, Luc, Dumusque, Xavier, Dupret, Marc-Antoine, Eggenberger, Patrick, Ehrenreich, David, Eigmüller, Philipp, Eising, Johannes, Emilio, Marcelo, Eriksson, Kjell, Ermocida, Marco, Giribaldi, Riano Isidoro Escate, Eschen, Yoshi, Estrela, Inês, Evans, Dafydd Wyn, Fabbian, Damian, Fabrizio, Michele, Faria, João Pedro, Farina, Maria, Farinato, Jacopo, Feliz, Dax, Feltzing, Sofia, Fenouillet, Thomas, Ferrari, Lorenza, Ferraz-Mello, Sylvio, Fialho, Fabio, Fienga, Agnes, Figueira, Pedro, Fiori, Laura, Flaccomio, Ettore, Focardi, Mauro, Foley, Steve, Fontignie, Jean, Ford, Dominic, Fornazier, Karin, Forveille, Thierry, Fossati, Luca, Franca, Rodrigo de Marca, da Silva, Lucas Franco, Frasca, Antonio, Fridlund, Malcolm, Furlan, Marco, Gabler, Sarah-Maria, Gaido, Marco, Gallagher, Andrew, Galli, Emanuele, Garcia, Rafael A., Hernández, Antonio García, Munoz, Antonio Garcia, García-Vázquez, Hugo, Haba, Rafael Garrido, Gaulme, Patrick, Gauthier, Nicolas, Gehan, Charlotte, Gent, Matthew, Georgieva, Iskra, Ghigo, Mauro, Giana, Edoardo, Gill, Samuel, Girardi, Leo, Winter, Silvia Giuliatti, Giusi, Giovanni, da Silva, João Gomes, Zazo, Luis Jorge Gómez, Gomez-Lopez, Juan Manuel, Hernández, Jonay Isai González, Murillo, Kevin Gonzalez, Gorius, Nicolas, Gouel, Pierre-Vincent, Goulty, Duncan, Granata, Valentina, Grenfell, John Lee, Grießbach, Denis, Grolleau, Emmanuel, Grouffal, Salomé, Grziwa, Sascha, Guarcello, Mario Giuseppe, Gueguen, Loïc, Guenther, Eike Wolf, Guilhem, Terrasa, Guillerot, Lucas, Guiot, Pierre, Guterman, Pascal, Gutiérrez, Antonio, Gutiérrez-Canales, Fernando, Hagelberg, Janis, Haldemann, Jonas, Hall, Cassandra, Handberg, Rasmus, Harrison, Ian, Harrison, Diana L., Hasiba, Johann, Haswell, Carole A., Hatalova, Petra, Hatzes, Artie, Haywood, Raphaelle, Hébrard, Guillaume, Heckes, Frank, Heiter, Ulrike, Hekker, Saskia, Heller, René, Helling, Christiane, Helminiak, Krzysztof, Hemsley, Simon, Heng, Kevin, Hermans, Aline, Hermes, JJ, Torres, Nadia Hidalgo, Hinkel, Natalie, Hobbs, David, Hodgkin, Simon, Hofmann, Karl, Hojjatpanah, Saeed, Houdek, Günter, Huber, Daniel, Huesler, Joseph, Hui-Bon-Hoa, Alain, Huygen, Rik, Huynh, Duc-Dat, Iro, Nicolas, Irwin, Jonathan, Irwin, Mike, Izidoro, André, Jacquinod, Sophie, Jannsen, Nicholas Emborg, Janson, Markus, Jeszenszky, Harald, Jiang, Chen, Mancebo, Antonio José Jimenez, Jofre, Paula, Johansen, Anders, Johnston, Cole, Jones, Geraint, Kallinger, Thomas, Kálmán, Szilárd, Kanitz, Thomas, Karjalainen, Marie, Karjalainen, Raine, Karoff, Christoffer, Kawaler, Steven, Kawata, Daisuke, Keereman, Arnoud, Keiderling, David, Kennedy, Tom, Kenworthy, Matthew, Kerschbaum, Franz, Kidger, Mark, Kiefer, Flavien, Kintziger, Christian, Kislyakova, Kristina, Kiss, László, Klagyivik, Peter, Klahr, Hubert, Klevas, Jonas, Kochukhov, Oleg, Köhler, Ulrich, Kolb, Ulrich, Koncz, Alexander, Korth, Judith, Kostogryz, Nadiia, Kovács, Gábor, Kovács, József, Kozhura, Oleg, Krivova, Natalie, Kučinskas, Arunas, Kuhlemann, Ilyas, Kupka, Friedrich, Laauwen, Wouter, Labiano, Alvaro, Lagarde, Nadege, Laget, Philippe, Laky, Gunter, Lam, Kristine Wai Fun, Lambrechts, Michiel, Lammer, Helmut, Lanza, Antonino Francesco, Lanzafame, Alessandro, Martiz, Mariel Lares, Laskar, Jacques, Latter, Henrik, Lavanant, Tony, Lawrenson, Alastair, Lazzoni, Cecilia, Lebre, Agnes, Lebreton, Yveline, Etangs, Alain Lecavelier des, Leinhardt, Zoe, Leleu, Adrien, Lendl, Monika, Leto, Giuseppe, Levillain, Yves, Libert, Anne-Sophie, Lichtenberg, Tim, Ligi, Roxanne, Lignieres, Francois, Lillo-Box, Jorge, Linsky, Jeffrey, Liu, John Scige, Loidolt, Dominik, Longval, Yuying, Lopes, Ilídio, Lorenzani, Andrea, Ludwig, Hans-Guenter, Lund, Mikkel, Lundkvist, Mia Sloth, Luri, Xavier, Maceroni, Carla, Madden, Sean, Madhusudhan, Nikku, Maggio, Antonio, Magliano, Christian, Magrin, Demetrio, Mahy, Laurent, Maibaum, Olaf, Malac-Allain, LeeRoy, Malapert, Jean-Christophe, Malavolta, Luca, Maldonado, Jesus, Mamonova, Elena, Manchon, Louis, Mann, Andrew, Mantovan, Giacomo, Marafatto, Luca, Marconi, Marcella, Mardling, Rosemary, Marigo, Paola, Marinoni, Silvia, Marques, Érico, Marques, Joao Pedro, Marrese, Paola Maria, Marshall, Douglas, Perales, Silvia Martínez, Mary, David, Marzari, Francesco, Masana, Eduard, Mascher, Andrina, Mathis, Stéphane, Mathur, Savita, Figueiredo, Ana Carolina Mattiuci, Maxted, Pierre F. L., Mazeh, Tsevi, Mazevet, Stephane, Mazzei, Francesco, McCormac, James, McMillan, Paul, Menou, Lucas, Merle, Thibault, Meru, Farzana, Mesa, Dino, Messina, Sergio, Mészáros, Szabolcs, Meunier, Nadége, Meunier, Jean-Charles, Micela, Giuseppina, Michaelis, Harald, Michel, Eric, Michielsen, Mathias, Michtchenko, Tatiana, Miglio, Andrea, Miguel, Yamila, Milligan, David, Mirouh, Giovanni, Mitchell, Morgan, Moedas, Nuno, Molendini, Francesca, Molnár, László, Mombarg, Joey, Montalban, Josefina, Montalto, Marco, Monteiro, Mário J. P. F. G., Morales, Juan Carlos, Morales-Calderon, Maria, Morbidelli, Alessandro, Mordasini, Christoph, Moreau, Chrystel, Morel, Thierry, Morello, Guiseppe, Morin, Julien, Mortier, Annelies, Mosser, Benoît, Mourard, Denis, Mousis, Olivier, Moutou, Claire, Mowlavi, Nami, Moya, Andrés, Muehlmann, Prisca, Muirhead, Philip, Munari, Matteo, Musella, Ilaria, Mustill, Alexander James, Nardetto, Nicolas, Nardiello, Domenico, Narita, Norio, Nascimbeni, Valerio, Nash, Anna, Neiner, Coralie, Nelson, Richard P., Nettelmann, Nadine, Nicolini, Gianalfredo, Nielsen, Martin, Niemi, Sami-Matias, Noack, Lena, Noels-Grotsch, Arlette, Noll, Anthony, Norazman, Azib, Norton, Andrew J., Nsamba, Benard, Ofir, Aviv, Ogilvie, Gordon, Olander, Terese, Olivetto, Christian, Olofsson, Göran, Ong, Joel, Ortolani, Sergio, Oshagh, Mahmoudreza, Ottacher, Harald, Ottensamer, Roland, Ouazzani, Rhita-Maria, Paardekooper, Sijme-Jan, Pace, Emanuele, Pajas, Miriam, Palacios, Ana, Palandri, Gaelle, Palle, Enric, Paproth, Carsten, Parro, Vanderlei, Parviainen, Hannu, Granado, Javier Pascual, Passegger, Vera Maria, Pastor-Morales, Carmen, Pätzold, Martin, Pedersen, May Gade, Hidalgo, David Pena, Pepe, Francesco, Pereira, Filipe, Persson, Carina M., Pertenais, Martin, Peter, Gisbert, Petit, Antoine C., Petit, Pascal, Pezzuto, Stefano, Pichierri, Gabriele, Pietrinferni, Adriano, Pinheiro, Fernando, Pinsonneault, Marc, Plachy, Emese, Plasson, Philippe, Plez, Bertrand, Poppenhaeger, Katja, Poretti, Ennio, Portaluri, Elisa, Portell, Jordi, de Mello, Gustavo Frederico Porto, Poyatos, Julien, Pozuelos, Francisco J., Moroni, Pier Giorgio Prada, Pricopi, Dumitru, Prisinzano, Loredana, Quade, Matthias, Quirrenbach160, ndreas, Reina6, Julio Arturo Rabanal, Soares, Maria Cristina Rabello, Raimondo, Gabriella, Rainer, Monica, Rodón, Jose Ramón, Ramón-Ballesta, Alejandro, Zapata, Gonzalo Ramos, Rätz, Stefanie, Rauterberg, Christoph, Redman, Bob, Redmer, Ronald, Reese, Daniel, Regibo, Sara, Reiners, Ansgar, Reinhold, Timo, Renie, Christian, Ribas, Ignasi, Ribeiro, Sergio, Ricciardi, Thiago Pereira, Rice, Ken, Richard, Olivier, Riello, Marco, Rieutord, Michel, Ripepi, Vincenzo, Rixon, Guy, Rockstein, Steve, Rodríguez, María Teresa Rodrigo, Díaz, Luisa Fernanda Rodríguez, Garcia, Juan Pablo Rodriguez, Rodriguez-Gomez, Julio, Roehlly, Yannick, Roig, Fernando, Rojas-Ayala, Bárbara, Rolf, Tobias, Rørsted, Jakob Lysgaard, Rosado, Hugo, Rosotti, Giovanni, Roth, Olivier, Roth, Markus, Rousseau, Alex, Roxburgh, Ian, Roy, Fabrice, Royer, Pierre, Ruane, Kirk, Mastropasqua, Sergio Rufini, de Galarreta, Claudia Ruiz, Russi, Andrea, Saar, Steven, Saillenfest, Melaine, Salaris, Maurizio, Salmon, Sebastien, Saltas, Ippocratis, Samadi, Réza, Samadi, Aunia, Samra, Dominic, da Silva, Tiago Sanches, Carrasco, Miguel Andrés Sánchez, Santerne, Alexandre, Santoli, Francesco, Santos, Ângela R. G., Mesa, Rosario Sanz, Sarro, Luis Manuel, Scandariato, Gaetano, Schäfer, Martin, Schlafly, Edward, Schmider, François-Xavier, Schneider, Jean, Schou, Jesper, Schunker, Hannah, Schwarzkopf, Gabriel Jörg, Serenelli, Aldo, Seynaeve, Dries, Shan, Yutong, Shapiro, Alexander, Shipman, Russel, Sicilia, Daniela, Sanmartin, Maria Angeles Sierra, Sigot, Axelle, Silliman, Kyle, Silvotti, Roberto, Simon, Attila E., Napoli, Ricardo Simoyama, Skarka, Marek, Smalley, Barry, Smiljanic, Rodolfo, Smit, Samuel, Smith, Alexis, Smith, Leigh, Snellen, Ignas, Sódor, Ádám, Sohl, Frank, Solanki, Sami K., Sortino, Francesca, Sousa, Sérgio, Southworth, John, Souto, Diogo, Sozzetti, Alessandro, Stamatellos, Dimitris, Stassun, Keivan, Steller, Manfred, Stello, Dennis, Stelzer, Beate, Stiebeler, Ulrike, Stokholm, Amalie, Storelvmo, Trude, Strassmeier, Klaus, Strøm, Paul Anthony, Strugarek, Antoine, Sulis, Sophia, Švanda, Michal, Szabados, László, Szabó, Róbert, Szabó, Gyula M., Szuszkiewicz, Ewa, Talens, Geert Jan, Teti, Daniele, Theisen, Tom, Thévenin, Frédéric, Thoul, Anne, Tiphene, Didier, Titz-Weider, Ruth, Tkachenko, Andrew, Tomecki, Daniel, Tonfat, Jorge, Tosi, Nicola, Trampedach, Regner, Traven, Gregor, Triaud, Amaury, Trønnes, Reidar, Tsantaki, Maria, Tschentscher, Matthias, Turin, Arnaud, Tvaruzka, Adam, Ulmer, Bernd, Ulmer-Moll, Solène, Ulusoy, Ceren, Umbriaco, Gabriele, Valencia, Diana, Valentini, Marica, Valio, Adriana, Guijarro, Ángel Luis Valverde, Van Eylen, Vincent, Van Grootel, Valerie, van Kempen, Tim A., Van Reeth, Timothy, Van Zelst, Iris, Vandenbussche, Bart, Vasiliou, Konstantinos, Vasilyev, Valeriy, de Mascarenhas, David Vaz, Vazan, Allona, Nunez, Marina Vela, Velloso, Eduardo Nunes, Ventura, Rita, Ventura, Paolo, Venturini, Julia, Trallero, Isabel Vera, Veras, Dimitri, Verdugo, Eva, Verma, Kuldeep, Vibert, Didier, Martinez, Tobias Vicanek, Vida, Krisztián, Vigan, Arthur, Villacorta, Antonio, Villaver, Eva, Aparicio, Marcos Villaverde, Viotto, Valentina, Vorobyov, Eduard, Vorontsov, Sergey, Wagner, Frank W., Walloschek, Thomas, Walton, Nicholas, Walton, Dave, Wang, Haiyang, Waters, Rens, Watson, Christopher, Wedemeyer, Sven, Weeks, Angharad, Weingril, Jörg, Weiss, Annita, Wendler, Belinda, West, Richard, Westerdorff, Karsten, Westphal, Pierre-Amaury, Wheatley, Peter, White, Tim, Whittaker, Amadou, Wickhusen, Kai, Wilson, Thomas, Windsor, James, Winter, Othon, Winther, Mark Lykke, Winton, Alistair, Witteck, Ulrike, Witzke, Veronika, Woitke, Peter, Wolter, David, Wuchterl, Günther, Wyatt, Mark, Yang, Dan, Yu, Jie, Sanchez, Ricardo Zanmar, Osorio, María Rosa Zapatero, Zechmeister, Mathias, Zhou, Yixiao, Ziemke, Claas, and Zwintz, Konstanze
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Astrophysics - Instrumentation and Methods for Astrophysics ,Astrophysics - Earth and Planetary Astrophysics ,Astrophysics - Solar and Stellar Astrophysics - Abstract
PLATO (PLAnetary Transits and Oscillations of stars) is ESA's M3 mission designed to detect and characterise extrasolar planets and perform asteroseismic monitoring of a large number of stars. PLATO will detect small planets (down to <2 R_(Earth)) around bright stars (<11 mag), including terrestrial planets in the habitable zone of solar-like stars. With the complement of radial velocity observations from the ground, planets will be characterised for their radius, mass, and age with high accuracy (5 %, 10 %, 10 % for an Earth-Sun combination respectively). PLATO will provide us with a large-scale catalogue of well-characterised small planets up to intermediate orbital periods, relevant for a meaningful comparison to planet formation theories and to better understand planet evolution. It will make possible comparative exoplanetology to place our Solar System planets in a broader context. In parallel, PLATO will study (host) stars using asteroseismology, allowing us to determine the stellar properties with high accuracy, substantially enhancing our knowledge of stellar structure and evolution. The payload instrument consists of 26 cameras with 12cm aperture each. For at least four years, the mission will perform high-precision photometric measurements. Here we review the science objectives, present PLATO's target samples and fields, provide an overview of expected core science performance as well as a description of the instrument and the mission profile at the beginning of the serial production of the flight cameras. PLATO is scheduled for a launch date end 2026. This overview therefore provides a summary of the mission to the community in preparation of the upcoming operational phases.
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- 2024
19. Data-Error Scaling in Machine Learning on Natural Discrete Combinatorial Mutation-prone Sets: Case Studies on Peptides and Small Molecules
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Doffini, Vanni, von Lilienfeld, O. Anatole, and Nash, Michael A.
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Physics - Chemical Physics ,Computer Science - Machine Learning - Abstract
We investigate trends in the data-error scaling behavior of machine learning (ML) models trained on discrete combinatorial spaces that are prone-to-mutation, such as proteins or organic small molecules. We trained and evaluated kernel ridge regression machines using variable amounts of computationally generated training data. Our synthetic datasets comprise i) two na\"ive functions based on many-body theory; ii) binding energy estimates between a protein and a mutagenised peptide; and iii) solvation energies of two 6-heavy atom structural graphs. In contrast to typical data-error scaling, our results showed discontinuous monotonic phase transitions during learning, observed as rapid drops in the test error at particular thresholds of training data. We observed two learning regimes, which we call saturated and asymptotic decay, and found that they are conditioned by the level of complexity (i.e. number of mutations) enclosed in the training set. We show that during training on this class of problems, the predictions were clustered by the ML models employed in the calibration plots. Furthermore, we present an alternative strategy to normalize learning curves (LCs) and the concept of mutant based shuffling. This work has implications for machine learning on mutagenisable discrete spaces such as chemical properties or protein phenotype prediction, and improves basic understanding of concepts in statistical learning theory.
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- 2024
20. Understanding High-Order Network Structure using Permissible Walks on Attributed Hypergraphs
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Battistella, Enzo, English, Sean, Green, Robert, Joslyn, Cliff, Lagoda, Evgeniya, Magnan, Van, Myers, Audun, Nash, Evan D., and Robinson, Michael
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Computer Science - Social and Information Networks ,Mathematics - Combinatorics - Abstract
Hypergraphs have been a recent focus of study in mathematical data science as a tool to understand complex networks with high-order connections. One question of particular relevance is how to leverage information carried in hypergraph attributions when doing walk-based techniques. In this work, we focus on a new generalization of a walk in a network that recovers previous approaches and allows for a description of permissible walks in hypergraphs. Permissible walk graphs are constructed by intersecting the attributed $s$-line graph of a hypergraph with a relation respecting graph. The attribution of the hypergraph's line graph commonly carries over information from categorical and temporal attributions of the original hypergraph. To demonstrate this approach on a temporally attributed example, we apply our framework to a Reddit data set composed of hyperedges as threads and authors as nodes where post times are tracked.
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- 2024
21. Identifying Critical Employability Skills for Employment Success of Autistic Individuals: A Content Analysis of Job Postings
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Amy Jane Griffiths, Amy E. Hurley-Hanson, Cristina M. Giannantonio, Angel Miles Nash, Wallace Walrod, Petersen Walrod, Rachel Torres, and Raquel Delgado
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This study aimed to examine the literature on the skill sets of autistic individuals and determine how these skills align with current and projected future labour market needs. Based on a literature review, researchers identified the following skill categories common to autistic individuals: visual skills, attention to detail and systemizing composite skills. Researchers then gathered aggregated data on occupations and industries from over 90 state and federal sources in the United States. Next, they collected data on the most in-demand jobs, their industries and relevant skills by analysing hundreds of millions of online job postings. The results indicate the most viable occupations aligned with each skill category. There is minimal available research using labour market data to generate special education goals and transition plans for autistic students. By providing educators and practitioners with critical information regarding viable employment pathways, all stakeholders can more effectively and equitably prepare autistic individuals for the 21st-century workforce.
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- 2024
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22. Critical Inquiry in (and about) Media Environments: Examining an Asset-Based Digital Literacy Curriculum
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Brady Nash
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Scholars have long recognized that reading in digital spaces requires unique skills, strategies, and competencies in comparison to those needed for reading printed text. In recent years, the ubiquity of social media and algorithmically targeted content has radically changed the nature of online reading and meaning making. Technological changes have occurred simultaneously with radically altered sociocultural and sociopolitical contexts. To account for an altered technological and sociocultural landscape, new approaches to teaching digital reading and critical media literacy are needed. Addressing these concerns, this case study detailed a digital reading curriculum designed to be responsive to both the contemporary digital media environment and to students' out-of-school digital literacy practices and contexts. The curriculum was collaboratively designed by five middle-school language arts teachers who participated in a semester-long professional learning group focused on digital reading. Drawing upon sociocultural, asset-based, and culturally relevant philosophies of education, these five teachers designed a unique digital reading curriculum. This study examined the nature of this curriculum. The findings detailed four aspects of the teachers' unit: (1) digital reading instruction situated within students' literate lives; (2) critical instruction regarding systemic features of the internet such as algorithms and clickbait; (3) lessons in which students interrogate socially situated meaning making; and (4) lessons focused on the role of emotions while reading online. The findings have implications for future digital reading and media literacy curricula intended to be responsive to students' funds of knowledge, ever-changing literacy technologies, and new, emergent ways of reading and practicing literacy on the internet.
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- 2024
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23. Has the Time Come for Heutagogy? Supporting Neurodivergent Learners in Higher Education
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Zahava L. Friedman and Denise Nash-Luckenbach
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An increasing number of neurodivergent learners attend higher education. This necessitates examination of best-fit learning models to successfully support the current generation of college students. While pedagogy and andragogy have historical relevance, in isolation, they may lack alignment with the individualization embedded in neurodiversity-affirming practice. This study conceptualized a novel learning framework for neurodivergent college students through the lens of neurodiversity-affirming practice. Via constant comparative qualitative analysis of American university faculty interviews and framework juxtaposition, three themes were identified: pedagogy vs. andragogy, self-determination, and interdependency. Thematic analysis revealed uncertainty regarding best-fit learning framework, with consensus reached regarding complexity of serving neurodivergent adults in post-secondary settings. An innovative framework titled "Building a Heutagogical Bridge" was envisioned, describing the role of heutagogy, student-centered, self-determined learning, in connecting signature pedagogical and andragogical approaches. This study revealed the potentiality of implementing and assessing approaches to skillfully incorporate heutagogical, pedagogical, and andragogical principles in higher education settings. The perspectives of faculty from the USA within this study can inform neurodiversity-affirming practice in American universities, while providing implications for future study and practice in international college settings, where contexts, needs, and culture may differ.
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- 2024
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24. “Putting Science into Action”: A Case Study of How an Educational Intermediary Organization Synthesizes and Translates Research Evidence for Practice
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Metzger, Ashley, Duane, Addison, Nash, Amia, and Shapiro, Valerie
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Background: Knowledge brokering by intermediary organizations includes knowledge distillation processes (e.g., synthesis, translation).Aims and objectives: This article explores how an educational intermediary performs research distillation when creating virtual knowledge reservoirs for educators.Methods: The authors use qualitative data from semi-structured interviews, coded to consensus, and thematically analyzed.Findings: During synthesis, intermediaries apply a “research lens” to evaluate the credibility of the evidence. During translation, they rely on their experience as educators to share evidence in a non-academic voice and generate “turnkey” strategies.Discussion and conclusion: The article considers the knowledge brokering pipeline fallacy and examines the potential of ongoing processes for improving the effectiveness of intermediaries with the aim of diminishing research-practice and research-policy gaps in education.
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- 2024
25. Innovations and advances in instrumentation at the W. M. Keck Observatory, vol. III
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Kassis, Marc F, Alvarez, Carlos, Baker, Ashley D, Bailey, John I, Banyal, Ravinder K, Bertz, Rob, Beichman, Charles A, Bouchez, Antonin H, Brown, Aaron M, Brown, Matthew K, Bundy, Kevin A, Campbell, Randall D, Chun, Mark R, Cooke, Jeffrey, Deich, William T, Dekany, Richard G, Doppmann, Greg, Fassnacht, Christopher, Ferrara, Jocelyn, Fitzgerald, Michael P, Fremling, Christoffer, Fucik, Jason R, Gibson, Steven R, Gillingham, Peter R, Glazebrook, Karl, Greffe, Timothee, Halverson, Samuel P, Hill, Grant M, Hillenbrand, Lynne, Hinz, Philip M, Holden, Bradford P, Howard, Andrew W, Huber, Daniel, Jones, Tucker A, Jordan, Carolyn, Jovanovic, Nemanja J, Kain, Isabel J, Kasliwal, Mansi M, Kirby, Evan, Konopacky, Quinn M, Krishnan, Shanti, Kulkarni, Shrinivas R, Kupke, Renate, Lanclos, Kyle, Larkin, James E, Lilley, Scott J, Lingvay, Larry, Lu, Jessica R, Lyke, James E, MacDonald, Nicholas, Martin, Christopher, Mather, John C, Matuszewski, Mateusz, Mawet, Dimitri P, McGurk, Rosalie C, Marin, Eduardo, Meeks, Robert L, Millar-Blanchaer, Maxwell A, Nash, Reston B, Neill, James D, O'Meara, John M, Pahuja, Rishi, Peretz, Eliad, Prusinski, Nikolaus, Radovan, Matthew V, Rider, Kodi A, Roberts, Mitsuko K, Rockosi, Constance M, Rubenzahl, Ryan, Sallum, Stephanie E, Sandford, Dale, Savage, Maureen L, Skemer, Andrew J, Smith, Roger, Steidel, Charles, Steiner, Jonathan, Stelter, Richard D, Walawender, Josh, Westfall, Kyle B, Wizinowich, Peter L, Wright, Shelley A, Wold, Truman, and Zimmer, Jake
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- 2024
26. Photographic grading to evaluate facial cleanliness and trachoma among children in Amhara region, Ethiopia.
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Caleon, Ramoncito, Admassu, Fisseha, Aragie, Solomon, Hailu, Dagnachew, Dagnew, Adane, Zeru, Taye, Wittberg, Dionna, Thompson, Isabel, Abdu, Seid, Beyecha, Social, Birhanu, Tibebe, Getachew, Habib, Getnet, Banchalam, Kabtu, Endale, Shibiru, Meskerem, Tekew, Solomon, Wondimteka, Bilen, Lietman, Thomas, Nash, Scott, Freeman, Matthew, and Keenan, Jeremy
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Child ,Child ,Preschool ,Female ,Humans ,Infant ,Infant ,Newborn ,Male ,Chlamydia trachomatis ,Conjunctiva ,Cross-Sectional Studies ,Ethiopia ,Face ,Hygiene ,Photography ,Trachoma - Abstract
BACKGROUND: Promotion of facial cleanliness is recommended for the elimination of blinding trachoma, largely because of observational studies that have found an association between various measures of facial uncleanliness and trachoma. However, when a field grader assesses both facial cleanliness and trachoma, associations may be biased. Assessment of photographs of the face and conjunctiva by masked graders may provide a less biased estimate of the relationship between facial cleanliness and trachoma. METHODS: Face photographs, conjunctival photographs, and conjunctival swabs were obtained on a random sample of 0-9-year-old children from each of 40 communities in Amhara region, Ethiopia. Face photographs were assessed for the presence of seven measures of an unclean face (i.e., wet nasal discharge, dry nasal discharge, wet ocular discharge, dry ocular discharge, food, dust/dirt, and flies) by three independent masked photo-graders. Conjunctival photographs were similarly graded in a masked fashion for signs of clinically active trachoma. Conjunctival swabs were processed for Chlamydia trachomatis DNA. RESULTS: Of 2073 children with complete data, 808 (39%) had evidence of clinically active trachoma, 150 (7%) had evidence of ocular chlamydia infection, and 2524 (91%) had at least one measure of an unclean face. Dry ocular discharge had the strongest association with clinically active trachoma (age- and sex-adjusted prevalence ratio [PR] 1.4, 95% CI 1.2-1.6) and ocular chlamydia infection (PR 1.9, 95%CI 1.3-2.9), although significant associations were observed between each of the measures of facial uncleanliness and trachoma. CONCLUSIONS: Masked assessment of face and conjunctival photographs confirmed prior observational studies that have noted associations between various measures of facial uncleanliness and trachoma. The causal relationship between facial uncleanliness and trachoma is unclear since many features used to measure facial cleanliness (e.g., ocular discharge, nasal discharge, and flies) could be consequences of antecedent ocular chlamydia infection. TRIAL REGISTRATION: NCT02754583, clinicaltrials.gov.
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- 2024
27. Roadmap on methods and software for electronic structure based simulations in chemistry and materials
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Blum, Volker, Asahi, Ryoji, Autschbach, Jochen, Bannwarth, Christoph, Bihlmayer, Gustav, Blügel, Stefan, Burns, Lori A, Crawford, T Daniel, Dawson, William, de Jong, Wibe Albert, Draxl, Claudia, Filippi, Claudia, Genovese, Luigi, Giannozzi, Paolo, Govind, Niranjan, Hammes-Schiffer, Sharon, Hammond, Jeff R, Hourahine, Benjamin, Jain, Anubhav, Kanai, Yosuke, Kent, Paul RC, Larsen, Ask Hjorth, Lehtola, Susi, Li, Xiaosong, Lindh, Roland, Maeda, Satoshi, Makri, Nancy, Moussa, Jonathan, Nakajima, Takahito, Nash, Jessica A, Oliveira, Micael JT, Patel, Pansy D, Pizzi, Giovanni, Pourtois, Geoffrey, Pritchard, Benjamin P, Rabani, Eran, Reiher, Markus, Reining, Lucia, Ren, Xinguo, Rossi, Mariana, Schlegel, H Bernhard, Seriani, Nicola, Slipchenko, Lyudmila V, Thom, Alexander, Valeev, Edward F, Van Troeye, Benoit, Visscher, Lucas, Vlcek, Vojtech, Werner, Hans-Joachim, Williams-Young, David B, and Windus, Theresa
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Information and Computing Sciences ,Software Engineering ,Bioengineering - Abstract
Abstract: This Roadmap article provides a succinct, comprehensive overview of the state of electronic structure methods and software for molecular and materials simulations. Seventeen distinct sections collect insights by 51 leading scientists in the field. Each contribution addresses the status of a particular area, as well as current challenges and anticipated future advances, with a particular eye towards software related aspects and providing key references for further reading. Foundational sections cover density functional theory and its implementation in real-world simulation frameworks, Green's function based many-body perturbation theory, wave-function based and stochastic electronic structure approaches, relativistic effects and semiempirical electronic structure theory approaches. Subsequent sections cover nuclear quantum effects, real-time propagation of the electronic structure, challenges for computational spectroscopy simulations, and exploration of complex potential energy surfaces. The final sections summarize practical aspects, including computational workflows for complex simulation tasks, the impact of current and future high-performance computing architectures, software engineering practices, education and training to maintain and broaden the community, as well as the status of and needs for electronic structure based modeling from the vantage point of industry environments. Overall, the field of electronic structure software and method development continues to unlock immense opportunities for future scientific discovery, based on the growing ability of computations to reveal complex phenomena, processes and properties that are determined by the make-up of matter at the atomic scale, with high precision.
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- 2024
28. Retinal Dystrophies Associated With Peripherin-2: Genetic Spectrum and Novel Clinical Observations in 241 Patients.
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Heath Jeffery, Rachael, Thompson, Jennifer, Lo, Johnny, Chelva, Enid, Armstrong, Sean, Pulido, Jose, Procopio, Rebecca, Vincent, Andrea, Bianco, Lorenzo, Battaglia Parodi, Maurizio, Ziccardi, Lucia, Antonelli, Giulio, Barbano, Lucilla, Marques, João, Geada, Sara, Carvalho, Ana, Tang, Wei, Chan, Choi, Boon, Camiel, Hensman, Jonathan, Chen, Ta-Ching, Lin, Chien-Yu, Chen, Pei-Lung, Vincent, Ajoy, Tumber, Anupreet, Heon, Elise, Grigg, John, Jamieson, Robyn, Cornish, Elisa, Nash, Benjamin, Borooah, Shyamanga, Ayton, Lauren, Britten-Jones, Alexis, Edwards, Thomas, Ruddle, Jonathan, Sharma, Abhishek, Porter, Rowan, Lamey, Tina, McLaren, Terri, McLenachan, Samuel, Roshandel, Danial, and Chen, Fred
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Humans ,Peripherins ,Middle Aged ,Adult ,Male ,Female ,Adolescent ,Retinal Dystrophies ,Aged ,Visual Acuity ,Child ,Young Adult ,Electroretinography ,Child ,Preschool ,Phenotype ,Tomography ,Optical Coherence ,Mutation ,Fluorescein Angiography ,Genetic Association Studies ,Retrospective Studies ,DNA Mutational Analysis ,DNA ,Pedigree - Abstract
PURPOSE: To describe the clinical, electrophysiological and genetic spectrum of inherited retinal diseases associated with variants in the PRPH2 gene. METHODS: A total of 241 patients from 168 families across 15 sites in 9 countries with pathogenic or likely pathogenic variants in PRPH2 were included. Records were reviewed for age at symptom onset, visual acuity, full-field ERG, fundus colour photography, fundus autofluorescence (FAF), and SD-OCT. Images were graded into six phenotypes. Statistical analyses were performed to determine genotype-phenotype correlations. RESULTS: The median age at symptom onset was 40 years (range, 4-78 years). FAF phenotypes included normal (5%), butterfly pattern dystrophy, or vitelliform macular dystrophy (11%), central areolar choroidal dystrophy (28%), pseudo-Stargardt pattern dystrophy (41%), and retinitis pigmentosa (25%). Symptom onset was earlier in retinitis pigmentosa as compared with pseudo-Stargardt pattern dystrophy (34 vs 44 years; P = 0.004). The median visual acuity was 0.18 logMAR (interquartile range, 0-0.54 logMAR) and 0.18 logMAR (interquartile range 0-0.42 logMAR) in the right and left eyes, respectively. ERG showed a significantly reduced amplitude across all components (P < 0.001) and a peak time delay in the light-adapted 30-Hz flicker and single-flash b-wave (P < 0.001). Twenty-two variants were novel. The central areolar choroidal dystrophy phenotype was associated with 13 missense variants. The remaining variants showed marked phenotypic variability. CONCLUSIONS: We described six distinct FAF phenotypes associated with variants in the PRPH2 gene. One FAF phenotype may have multiple ERG phenotypes, demonstrating a discordance between structure and function. Given the vast spectrum of PRPH2 disease our findings are useful for future clinical trials.
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- 2024
29. Biosignatures from pre-oxygen photosynthesising life on TRAPPIST-1e
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Eager-Nash, Jake K., Daines, Stuart J., McDermott, James W., Andrews, Peter, Grain, Lucy A., Bishop, James, Rogers, Aaron A., Smith, Jack W. G., Khalek, Chadiga, Boxer, Thomas J., Mak, Mei Ting, Ridgway, Robert J., Hebrard, Eric, Lambert, F. Hugo, Lenton, Timothy M., and Mayne, Nathan J.
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Astrophysics - Earth and Planetary Astrophysics - Abstract
In order to assess observational evidence for potential atmospheric biosignatures on exoplanets, it will be essential to test whether spectral fingerprints from multiple gases can be explained by abiotic or biotic-only processes. Here, we develop and apply a coupled 1D atmosphere-ocean-ecosystem model to understand how primitive biospheres, which exploit abiotic sources of H2, CO and O2, could influence the atmospheric composition of rocky terrestrial exoplanets. We apply this to the Earth at 3.8 Ga and to TRAPPIST-1e. We focus on metabolisms that evolved before the evolution of oxygenic photosynthesis, which consume H2 and CO and produce potentially detectable levels of CH4. O2-consuming metabolisms are also considered for TRAPPIST-1e, as abiotic O2 production is predicted on M-dwarf orbiting planets. We show that these biospheres can lead to high levels of surface O2 (approximately 1-5 %) as a result of \ch{CO} consumption, which could allow high O2 scenarios, by removing the main loss mechanisms of atomic oxygen. Increasing stratospheric temperatures, which increases atmospheric OH can reduce the likelihood of such a state forming. O2-consuming metabolisms could also lower O2 levels to around 10 ppm and support a productive biosphere at low reductant inputs. Using predicted transmission spectral features from CH4, CO, O2/O3 and CO2 across the hypothesis space for tectonic reductant input, we show that biotically-produced CH4 may only be detectable at high reductant inputs. CO is also likely to be a dominant feature in transmission spectra for planets orbiting M-dwarfs, which could reduce the confidence in any potential biosignature observations linked to these biospheres., Comment: 29 pages, 19 figures
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- 2024
30. 3D simulations of TRAPPIST-1e with varying CO2, CH4 and haze profiles
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Mak, Mei Ting, Sergeev, Denis, Mayne, Nathan, Banks, Nahum, Eager-Nash, Jake, Manners, James, Arney, Giada, Hebrard, Eric, and Kohary, Krisztian
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Astrophysics - Earth and Planetary Astrophysics - Abstract
Using a 3D General Circulation Model, the Unified Model, we present results from simulations of a tidally-locked TRAPPIST-1e with varying carbon dioxide CO2 and methane CH4 gas concentrations, and their corresponding prescribed spherical haze profiles. Our results show that the presence of CO2 leads to a warmer atmosphere globally due to its greenhouse effect, with the increase of surface temperature on the dayside surface reaching up to ~14.1 K, and on the nightside up to ~21.2 K. Increasing presence of CH4 first elevates the surface temperature on the dayside, followed by a decrease due to the balance of tropospheric warming and stratospheric cooling. A thin layer of haze, formed when the partial pressures of CH4 to CO2 (pCH4/pCO2) = 0.1, leads to a dayside warming of ~4.9K due to a change in the water vapour H2O distribution. The presence of a haze layer that formed beyond the ratio of 0.1 leads to dayside cooling. The haze reaches an optical threshold thickness when pCH4/pCO2 ~0.4 beyond which the dayside mean surface temperature does not vary much. The planet is more favourable to maintaining liquid water on the surface (mean surface temperature above 273.15 K) when pCO2 is high, pCH4 is low and the haze layer is thin. The effect of CO2, CH4 and haze on the dayside is similar to that for a rapidly-rotating planet. On the contrary, their effect on the nightside depends on the wind structure and the wind speed in the simulation., Comment: 17 pages, 16 figures, 2 tables
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- 2024
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31. A General Bayesian Algorithm for the Autonomous Alignment of Beamlines
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Morris, T. W., Rakitin, M., Islegen-Wojdyla, A., Du, Y., Fedurin, M., Giles, A. C., Leshchev, D., Li, W. H., Moeller, P., Nash, B., Romasky, B., Stavitski, E., and Walter, A. L.
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Physics - Accelerator Physics ,Physics - Instrumentation and Detectors ,Physics - Optics - Abstract
Autonomous methods to align beamlines can decrease the amount of time spent on diagnostics, and also uncover better global optima leading to better beam quality. The alignment of these beamlines is a high-dimensional, expensive-to-sample optimization problem involving the simultaneous treatment of many optical elements with correlated and nonlinear dynamics. Bayesian optimization is a strategy of efficient global optimization that has proved successful in similar regimes in a wide variety of beamline alignment applications, though it has typically been implemented for particular beamlines and optimization tasks. In this paper, we present a basic formulation of Bayesian inference and Gaussian process models as they relate to multiobjective Bayesian optimization, as well as the practical challenges presented by beamline alignment. We show that the same general implementation of Bayesian optimization with special consideration for beamline alignment can quickly learn the dynamics of particular beamlines in an online fashion through hyperparameter fitting with no prior information. We present the implementation of a concise software framework for beamline alignment and test it on four different optimization problems for experiments at x-ray beamlines of the National Synchrotron Light Source II and the Advanced Light Source and an electron beam at the Accelerator Test Facility, along with benchmarking on a simulated digital twin. We discuss new applications of the framework, and the potential for a unified approach to beamline alignment at synchrotron facilities.
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- 2024
32. SHAPE MEMORY POLYMER TECHNOLOGY AND ITS MEDICAL APPLICATIONS: With actuation capabilities that respond to temperature or light, the potential uses for shape memory polymers in the biomedical arena is on the rise
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Hasan, Sayyeda Marziya, Koller, Maryanne, Nash, Landon, and Yeh, Chung
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EPUB (Standard) -- Usage ,Polymer industry -- Usage ,Polymers -- Usage ,Engineering and manufacturing industries ,Science and technology - Abstract
Shape memory polymers (SMPs) have been studied intensively over the last two decades, specifically for their uses in aerospace, textiles, robotics, and bio-medicine [1]. These materials are considered 'smart materials' [...]
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- 2024
33. Lack of Knowledge of Antibiotic Risks Contributes to Primary Care Patients' Expectations of Antibiotics for Common Symptoms
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Laytner, Lindsey A., Trautner, Barbara W., Nash, Susan, Zoorob, Roger, Okoh, Jennifer O., Amenta, Eva, Olmeda, Kiara, Salinas, Juanita, Paasche-Orlow, Michael K., and Grigoryan, Larissa
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Medical research ,Medicine, Experimental ,Diarrhea -- Complications and side effects -- Dosage and administration -- Physiological aspects ,Patients -- Surveys ,Health literacy -- Surveys ,Primary health care -- Surveys ,Symptomatology -- Drug therapy -- Surveys ,Patient education -- Surveys ,Health ,Science and technology - Abstract
Patient expectations of receiving antibiotics for common symptoms can trigger unnecessary use. We conducted a survey (n = 564) between January 2020 to June 2021 in public and private primary care clinics in Texas to study the prevalence and predictors of patients' antibiotic expectations for common symptoms/illnesses. We surveyed Black patients (33%) and Hispanic/Latine patients (47%), and over 93% expected to receive an antibiotic for at least 1 of the 5 pre-defined symptoms/illnesses. Public clinic patients were nearly twice as likely to expect antibiotics for sore throat, diarrhea, and cold/flu than private clinic patients. Lack of knowledge of potential risks of antibiotic use was associated with increased antibiotic expectations for diarrhea (odds ratio [OR] = 1.6; 95% CI, 1.1-2.4) and cold/flu symptoms (OR = 2.9; 95% CI, 2.0-4.4). Lower education and inadequate health literacy were predictors of antibiotic expectations for diarrhea. Future antibiotic stewardship interventions should tailor patient education materials to include information on antibiotic risks and guidance on appropriate antibiotic indications. Key words: antibiotic use; antimicrobial stewardship; primary care; antibiotic risks; patient expectations, https://doi.org/10.1370/afm.3161 INTRODUCTION Patients often receive antibiotic prescriptions to treat common viral symptoms/ illnesses, such as respiratory tract infection, (1-6) cold/flu, (7,8) and diarrhea, (9,10) despite guidelines recommending against these practices. [...]
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- 2024
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34. Evaluation of an Expansion Strategy for the Assessment-to-Instruction Professional Support System
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MDRC, Zhu, Pei, Alterman, Emma, Commins, Nicholas, and Nash, Peyton
- Abstract
The Assessment-to-Instruction (A2i) Professional Support System has been shown to be effective in improving literacy proficiency among young readers by combining data-driven technology with professional development (PD) activities to help teachers provide personalized literacy instruction. To identify efficient ways to expand the reach of A2i, this study uses a school-level randomized controlled trial design to assess the relative effectiveness of two PD models in implementing A2i and improving student literacy achievement. Fifty-nine schools in 20 school districts were randomly assigned to either a mixed-mode PD delivery model that combines in-person and virtual PD activities or a face-to-face model that is tested and resource-intensive. A cohort of 4,733 first-graders in these schools was followed and their reading achievement tracked for three years. Due to disruptions caused by the COVID-19 pandemic, the full implementation of A2i was not realized during the study period. As a result, while student achievement in reading was similar in mixed-mode and face-to-face schools across all three study years, such results might not reflect the actual relative effectiveness between the two PD models.
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- 2023
35. Postdigital Videogames Literacies: Thinking With, Through, and Beyond James Gee’s Learning Principles
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Bacalja, Alexander, Nichols, T. Phillip, Robinson, Bradley, Bhatt, Ibrar, Kucharczyk, Stefan, Zomer, Chris, Nash, Brady, Dupont, Bruno, De Cock, Rozane, Zaman, Bieke, Bonenfant, Maude, Grosemans, Eva, Abrams, Sandra Schamroth, Vallis, Carmen, Koutsogiannis, Dimitrios, Dishon, Gideon, Reed, Jack, Byers, Thomas, Fawzy, Rania Magdi, Hsu, Hsiao-Ping, Lowien, Nathan, Barton, Georgina, Callow, Jon, Liu, Zirui, Serafini, Frank, Vermeire, Zowi, deHaan, Jonathan, Croasdale, Alison, Torres-Toukoumidis, Angel, Xu, Xiao, and Schnaider, Karoline
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- 2024
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36. Video Games and Literacy Learning: Exploring the Research on Serious and Entertainment Games
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von Gillern, Sam and Nash, Brady
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- 2024
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37. Proteomics Reveals Divergent Cardiac Inflammatory and Metabolic Responses After Inhalation of Ambient Particulate Matter With or Without Ozone
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Ge, Yue, Nash, Maliha S., Winnik, Witold M., Bruno, Maribel, Padgett, William T., Grindstaff, Rachel D., Hazari, Mehdi S., and Farraj, Aimen K.
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- 2024
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38. Outcomes of Distal Rectal Cancer Patients Who Did Not Qualify for Watch-and-Wait: Comparison of Intersphincteric Resection Versus Abdominoperineal Resection
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Feferman, Yael, Verheij, Floris S., Williams, Hannah, Omer, Dana M., Pappou, Emmanouil P., Wei, Iris H., Widmar, Maria, Nash, Garrett M., Paty, Philip B., Smith, J. Joshua, Cercek, Andrea, Yaeger, Rona, Segal, Neil H., Romesser, Paul B., Crane, Christopher, Saltz, Leonard B., Weiser, Martin R., and Garcia-Aguilar, Julio
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- 2024
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39. Reduced Sense of Smell in Patients with Severe Chronic Rhinosinusitis and its Implications for Diagnosis and Management: A Narrative Review
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Soler, Zachary M., Nash, Scott, Lane, Andrew P., Patel, Zara M., Lee, Stella E., Fokkens, Wytske J., Corbett, Mark, Jacob-Nara, Juby A., and Sacks, Harry
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- 2024
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40. Experiences of Racism in Health Care and Medical Mistrust Shape Cancer Prevention and Control Behaviors Among Black Residents of Black Hawk County, Iowa: A Qualitative Study
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Williams, Ashley N. T., VanArsdale, Angela, Hirschey, Rachel, Askelson, Natoshia, and Nash, Sarah H.
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- 2024
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41. The use of echocardiography in the management of shock in critical care: a prospective, multi-centre, observational study
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Flower, Luke, Waite, Alicia, Boulton, Adam, Peck, Marcus, Akhtar, Waqas, Boyle, Andrew J., Gudibande, Sandeep, Ingram, Thomas E., Johnston, Brian, Marsh, Sarah, Miller, Ashley, Nash, Amy, Olusanya, Olusegun, Parulekar, Prashant, Wagstaff, Daniel, Wilkinson, Jonathan, and Proudfoot, Alastair G.
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- 2024
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42. Comparative Effectiveness of Bimekizumab and Ustekinumab in Patients with Psoriatic Arthritis at 52 Weeks Assessed Using a Matching-Adjusted Indirect Comparison
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Mease, Philip J., Warren, Richard B., Nash, Peter, Grouin, Jean-Marie, Lyris, Nikos, Taieb, Vanessa, Eells, Jason, and McInnes, Iain B.
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- 2024
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43. Comparative Effectiveness of Bimekizumab and Risankizumab in Patients with Psoriatic Arthritis at 52 Weeks Assessed Using a Matching-Adjusted Indirect Comparison
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Mease, Philip J., Warren, Richard B., Nash, Peter, Grouin, Jean-Marie, Lyris, Nikos, Willems, Damon, Taieb, Vanessa, Eells, Jason, and McInnes, Iain B.
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- 2024
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44. Trajectory of Subsequent Breast Cancer Diagnoses in a Diverse Patient Cohort with Breast Atypia
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Limberg, Jessica N., Thomas, Samantha M., Dalton, Juliet C., Ntowe, Koumani W., Nash, Amanda L., Chiba, Akiko, Plichta, Jennifer K., and Hwang, E. Shelley
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- 2024
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45. Morality and partisan social media engagement: a natural language examination of moral political messaging and engagement during the 2018 US midterm elections
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Wang, Meng-Jie, Yogeeswaran, Kumar, Nash, Kyle, and Sivaram, Sivanand
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- 2024
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46. Assessing Endoscopic Response in Locally Advanced Rectal Cancer Treated with Total Neoadjuvant Therapy: Development and Validation of a Highly Accurate Convolutional Neural Network
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Williams, Hannah, Thompson, Hannah M., Lee, Christina, Rangnekar, Aneesh, Gomez, Jorge T., Widmar, Maria, Wei, Iris H., Pappou, Emmanouil P., Nash, Garrett M., Weiser, Martin R., Paty, Philip B., Smith, J. Joshua, Veeraraghavan, Harini, and Garcia-Aguilar, Julio
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- 2024
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47. Comparing Tretinoin to Other Topical Therapies in the Treatment of Skin Photoaging: A Systematic Review
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Siddiqui, Zoya, Zufall, Alina, Nash, Marissa, Rao, Divya, Hirani, Rahim, and Russo, Marian
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- 2024
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48. Risk of adverse infant outcomes associated with maternal mental health and substance use disorders
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Brown, Clare C., Tilford, J. Mick, Thomsen, Michael, Amick, Benjamin C., Bryant-Moore, Keneshia, Gomez-Acevedo, Horacio, Nash, Creshelle, and Moore, Jennifer E.
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- 2024
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49. Germline genetic mutations in a multi-center cohort of 248 phyllodes tumors
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Rosenberger, Laura H., Thomas, Samantha M., Hieken, Tina J., Gallagher, Kristalyn K., Spanheimer, Philip M., Neuman, Heather B., Weiss, Anna C., King, Tari A., Wong, Jasmine, Tong, Barry S., Nash, Amanda L., Frazier, Margaret Powell, Menendez, Carolyn S., Hwang, E. Shelley, Jakub, James W., and Plichta, Jennifer K.
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- 2024
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50. An engineered human cardiac tissue model reveals contributions of systemic lupus erythematosus autoantibodies to myocardial injury
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Fleischer, Sharon, Nash, Trevor R., Tamargo, Manuel A., Lock, Roberta I., Venturini, Gabriela, Morsink, Margaretha, Graney, Pamela L., Li, Vanessa, Lamberti, Morgan J., Liberman, Martin, Kim, Youngbin, Tavakol, Daniel N., Zhuang, Richard Z., Whitehead, Jaron, Friedman, Richard A., Soni, Rajesh K., Seidman, Jonathan G., Seidman, Christine E., Geraldino-Pardilla, Laura, Winchester, Robert, and Vunjak-Novakovic, Gordana
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- 2024
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