203 results on '"Narjes, Frank"'
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2. Analyzing proteolytic stability and metabolic hotspots of therapeutic peptides in two rodent pulmonary fluids
3. Automated high-throughput in vitro assays to identify metabolic hotspots and protease stability of structurally diverse, pharmacologically active peptides for inhalation
4. Kinetic Modeling of PROTAC‐Induced Protein Degradation
5. Theoretical studies of the second step of the nitric oxide synthase reaction: Electron tunneling prevents uncoupling
6. Discovery and Characterization of a Bicyclic Peptide (Bicycle) Binder to Thymic Stromal Lymphopoietin.
7. Recent Advances in the Discovery of Inhaled Anti-Inflammatory Treatments
8. A cell-active cyclic peptide targeting the Nrf2/Keap1 protein–protein interaction.
9. A cell-active peptide targeting the Nrf2/Keap1 protein-protein interaction
10. CHAPTER 20. Lead Generation
11. AZD0284, a Potent, Selective, and Orally Bioavailable Inverse Agonist of Retinoic Acid Receptor-Related Orphan Receptor C2
12. Mechanism-Based Insights into Removing the Mutagenicity of Aromatic Amines by Small Structural Alterations
13. Alpha-ketoacids are potent slow binding inhibitors of the hepatitis C virus NS3 protease
14. Synthesis of vinylcyclopropanes by intramolecular epoxide ring opening: application for an enantioselective synthesis of dictyopterene A
15. Discovery of Potent and Orally Bioavailable Inverse Agonists of the Retinoic Acid Receptor-Related Orphan Receptor C2
16. Emerging modes-of-action in drug discovery
17. Potent and Orally Bioavailable Inverse Agonists of RORγt Resulting from Structure-Based Design
18. Identification of indole inhibitors of human hematopoietic prostaglandin D2 synthase (hH-PGDS)
19. HTS followed by NMR based counterscreening. Discovery and optimization of pyrimidones as reversible and competitive inhibitors of xanthine oxidase
20. Back Cover: Benzoxazepines Achieve Potent Suppression of IL-17 Release in Human T-Helper 17 (TH17) Cells through an Induced-Fit Binding Mode to the Nuclear Receptor RORγ (ChemMedChem 2/2016)
21. Benzoxazepines Achieve Potent Suppression of IL-17 Release in Human T-Helper 17 (TH17) Cells through an Induced-Fit Binding Mode to the Nuclear Receptor RORγ
22. Cyclic phosphoramidates as prodrugs of 2′- C-methylcytidine
23. Improved modular synthesis of thieno[3,2- b]pyrroles and thieno[2,3- b]pyrroles
24. 2-(3-Thienyl)-5,6-dihydroxypyrimidine-4-carboxylic acids as inhibitors of HCV NS5B RdRp
25. Synthesis and evaluation of novel phosphoramidate prodrugs of 2′-methyl cytidine as inhibitors of hepatitis c virus NS5B polymerase
26. Synthesis and SAR of piperazinyl- N-phenylbenzamides as inhibitors of hepatitis C virus RNA replication in cell culture
27. Tetracyclic indole inhibitors of hepatitis C virus NS5B-polymerase
28. Discovery of pentacyclic compounds as potent inhibitors of hepatitis C virus NS5B RNA polymerase
29. Benzoxazepines Achieve Potent Suppression of IL-17 Release in Human T-Helper 17 (TH17) Cells through an Induced-Fit Binding Mode to the Nuclear Receptor RORγ.
30. Development of a Scalable Chiral Synthesis of MK-3281, an Inhibitor of the Hepatitis C Virus NS5B Polymerase
31. Discovery of (7R)-14-Cyclohexyl-7-{[2-(dimethylamino)ethyl](methyl) amino}-7,8-dihydro-6H-indolo[1,2-e][1,5]benzoxazocine-11-carboxylic Acid (MK-3281), a Potent and Orally Bioavailable Finger-Loop Inhibitor of the Hepatitis C Virus NS5B Polymerase
32. Enhancement of intestinal absorption of 2-methyl cytidine prodrugs
33. Mechanism of Hepatitis C Virus RNA Polymerase Inhibition with Dihydroxypyrimidines
34. ChemInform Abstract: Synthesis of Indolo[2,1-a][2]benzazepine and Indolo[2,1-a][2]-benzazocine.
35. Optimization of Thienopyrrole-Based Finger-Loop Inhibitors of the Hepatitis C Virus NS5B Polymerase
36. Phosphoramidate Prodrugs of 2′-C-Methylcytidine for Therapy of Hepatitis C Virus Infection
37. Identification and Biological Evaluation of a Series of 1H-Benzo[de]isoquinoline-1,3(2H)-diones as Hepatitis C Virus NS5B Polymerase Inhibitors
38. ChemInform Abstract: Improved Modular Synthesis of Thieno[3,2‐b]pyrroles and Thieno[2,3‐b]pyrroles.
39. ChemInform Abstract: Discovery of Pentacyclic Compounds as Potent Inhibitors of Hepatitis C Virus NS5B RNA Polymerase.
40. Synthesis of Indolo[2,1-a][2]benzazepine and Indolo[2,1-a][2]-benzazocine
41. Binding of a Noncovalent Inhibitor Exploiting the S′ region Stabilizes the Hepatitis C virus NS3 Protease Conformation in the Absence of Cofactor
42. Development of carboxylic acid replacements in indole- N-acetamide inhibitors of hepatitis C virus NS5B polymerase
43. Suzuki Coupling at the 2‐Position of Densely Functionalized Pyrimidones.
44. Identification of thieno[3,2-b]pyrroles as allosteric inhibitors of hepatitis C virus NS5B polymerase
45. Inhibitors of the hepatitis C virus RNA-dependent RNA polymerase
46. Allosteric Inhibition of the Hepatitis C Virus NS5B RNA Dependent RNA Polymerase
47. 2-(2-Thienyl)-5,6-dihydroxy-4-carboxypyrimidines as Inhibitors of the Hepatitis C Virus NS5B Polymerase: Discovery, SAR, Modeling, and Mutagenesis
48. Interdomain Communication in Hepatitis C Virus Polymerase Abolished by Small Molecule Inhibitors Bound to a Novel Allosteric Site
49. The Role of an Amphiphilic Capping Group in Covalent and Non-Covalent Dipeptide Inhibitors of HCV NS3 Serine Protease
50. Development and Preliminary Optimization of Indole-N-Acetamide Inhibitors of Hepatitis C Virus NS5B Polymerase
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