1. Synthesis, Antibacterial and Antitubercular Evaluation of Cardanol and Glycerol‑Based β-Amino Alcohol Derivatives
- Author
-
Ana Camila Micheletti, Maria Rita Marques, Narendar R. Thatikonda, Adilson Beatriz, Wanderson Romão, Heloa Santos, Camila Maríngolo Ribeiro, Dênis Pires de Lima, Edson dos Anjos dos Santos, Layla R. Barbosa, Bhaskar R. Manda, Valdemar Lacerda, Fernando Rogério Pavan, Avvari N. Prasad, Universidade Federal de Mato Grosso do Sul (UFMS), Universidade Federal do Espírito Santo (UFES), and Universidade Estadual Paulista (Unesp)
- Subjects
Cardanol ,antimicrobial activity ,Chromatography ,010405 organic chemistry ,Alcohol ,General Chemistry ,amino alcohols ,010402 general chemistry ,medicine.disease_cause ,Antimicrobial ,01 natural sciences ,0104 chemical sciences ,chemistry.chemical_compound ,Minimum inhibitory concentration ,chemistry ,Staphylococcus aureus ,medicine ,Glycerol ,Bioassay ,cardanol ,CNSL ,epoxide ring opening ,Escherichia coli - Abstract
Made available in DSpace on 2018-11-29T06:20:41Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-03-01. Added 1 bitstream(s) on 2019-10-09T18:25:56Z : No. of bitstreams: 1 S0103-50532018000300639.pdf: 347454 bytes, checksum: 0e8bf43c43cd9b732cb0cc1b7921b7cd (MD5) FUNDECT (PRONEM) Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Kardol Ind. Quimica Ltda. The synthesis of novel amino alcohol derivatives based on cardanol and glycerol were achieved in good yields and characterized by H-1 and C-13 NMR (nuclear magnetic resonance) and MS (mass spectrometry). In addition, we evaluated the in vitro antimicrobial activity against Gram-positive (Staphylococcus aureus, standard and clinical strains), Gram-negative (Escherichia coli) and M. tuberculosis bacterial strains. The bioassay results indicated that four compounds showed activity against S. aureus, including the clinical resistant strain, with MIC (minimum inhibitory concentration) ranging from 3.90 to 15.60 mu g mL(-1) and M. tuberculosis, with MIC90 (minimum inhibitory concentration required to inhibit the growth of 90% of organisms) ranging from 3.18 to 7.36 mu g mL(-1). Univ Fed Mato Grosso Do Sul, Inst Quim INQUI, Av Senador Felinto Muller 1555, BR-79074460 Campo Grande, MS, Brazil Univ Fed Espirito Santo, Dept Quim, BR-29075910 Vitoria, ES, Brazil Univ Estadual Paulista, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil Univ Fed Mato Grosso Do Sul, Inst Biociencias INBIO, Cidade Univ S-N,CP 549, BR-79070900 Campo Grande, MS, Brazil Univ Estadual Paulista, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP, Brazil FUNDECT (PRONEM): 054/12
- Published
- 2017
- Full Text
- View/download PDF