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9 results on '"Nardou, Katya"'

5. Complex molecular mechanisms cooperate to mediate histone deacetylase inhibitors anti-tumour activity in neuroblastoma cells

Author

Nardou Katya, Bourloud Katia, Flahaut Marjorie, Meier Roland, Mühlethaler-Mottet Annick, Joseph Jean-Marc, and Gross Nicole

Subjects
Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Histone deacetylase inhibitors (HDACi) are a new class of promising anti-tumour agent inhibiting cell proliferation and survival in tumour cells with very low toxicity toward normal cells. Neuroblastoma (NB) is the second most common solid tumour in children still associated with poor outcome in higher stages and, thus NB strongly requires novel treatment modalities. Results We show here that the HDACi Sodium Butyrate (NaB), suberoylanilide hydroxamic acid (SAHA) and Trichostatin A (TSA) strongly reduce NB cells viability. The anti-tumour activity of these HDACi involved the induction of cell cycle arrest in the G2/M phase, followed by the activation of the intrinsic apoptotic pathway, via the activation of the caspases cascade. Moreover, HDACi mediated the activation of the pro-apoptotic proteins Bid and BimEL and the inactivation of the anti-apoptotic proteins XIAP, Bcl-xL, RIP and survivin, that further enhanced the apoptotic signal. Interestingly, the activity of these apoptosis regulators was modulated by several different mechanisms, either by caspases dependent proteolytic cleavage or by degradation via the proteasome pathway. In addition, HDACi strongly impaired the hypoxia-induced secretion of VEGF by NB cells. Conclusion HDACi are therefore interesting new anti-tumour agents for targeting highly malignant tumours such as NB, as these agents display a strong toxicity toward aggressive NB cells and they may possibly reduce angiogenesis by decreasing VEGF production by NB cells.

Published
2008
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6. Transient postnatal overfeeding causes liver stress-induced premature senescence in adult mice

Author

Yzydorczyk, Catherine, primary, Li, Na, additional, Chehade, Hassib, additional, Mosig, Dolores, additional, Bidho, Mickael, additional, Keshavjee, Basile, additional, Armengaud, Jean Baptiste, additional, Nardou, Katya, additional, Siddeek, Benazir, additional, Benahmed, Mohamed, additional, Vergely, Catherine, additional, and Simeoni, Umberto, additional

Published
2017
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9. Renal programming by transient postnatal overfeeding: the role of senescence pathways

Author

Juvet, Christian, Benazir Siddeek, Yzydorczyk, Catherine, Vergely, Catherine, Nardou, Katya, Jean-Baptiste Armengaud, Benahmed, Mohamed, Simeoni, Umberto, Cachat, François, and Chehade, Hassib

Subjects
2. Zero hunger
Abstract

Western Blots for the following proteins in the mouse kidney at weaning and adulthood: P-Rb, Rb, P16, P21, P53, Sirt1. Actin was used for for normalization. CTRL: control group. OF: overfeeding group.

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