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1. Wound Healing from Bench to Bedside: A PPPM Bridge Between Physical Therapies and Chronic Inflammation

Author

Liu, Yuanhua, Liang, Yongying, Zhou, Xiaoyuan, Dent, Jennifer E., di Nardo, Lucia, Jiang, Ting, Qin, Ding, Lu, Youtao, He, Dongyi, Nardini, Christine, Golubnitschaja, Olga, Series Editor, Baban, Babak, Editorial Board Member, Bubnov, Rostylav, Editorial Board Member, Costigliola, Vincenzo, Editorial Board Member, Grech, Godfrey, Editorial Board Member, Mozaffari, Mahmood, Editorial Board Member, Parini, Paolo, Editorial Board Member, Paul, Friedermann, Editorial Board Member, Yoo, Byong Chul, Editorial Board Member, Zhan, Xianquan, Editorial Board Member, Andrews, Russell J., Editorial Board Member, Fröhlich, Holger, Editorial Board Member, Kokubo, Yoshihiro, Editorial Board Member, Krapfenbauer, Kurt, Editorial Board Member, Podbielska, Halina, Editorial Board Member, Tasker, R. Andrew, Editorial Board Member, Nardini, Christine, Editorial Board Member, Chaari, Lotfi, Editorial Board Member, Polivka Jr., Jiri, Editorial Board Member, Mandel, Silvia, Editorial Board Member, Erb, Carl, Editorial Board Member, Wang, Wei, Editorial Board Member, and Kapalla, Marko, editor

Published
2023
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4. Early downregulation of hsa-miR-144-3p in serum from drug-naïve Parkinson’s disease patients

Author

Zago, Elisa, Dal Molin, Alessandra, Dimitri, Giovanna Maria, Xumerle, Luciano, Pirazzini, Chiara, Bacalini, Maria Giulia, Maturo, Maria Giovanna, Azevedo, Tiago, Spasov, Simeon, Gómez-Garre, Pilar, Periñán, María Teresa, Jesús, Silvia, Baldelli, Luca, Sambati, Luisa, Calandra-Buonaura, Giovanna, Garagnani, Paolo, Provini, Federica, Cortelli, Pietro, Mir, Pablo, Trenkwalder, Claudia, Mollenhauer, Brit, Franceschi, Claudio, Liò, Pietro, and Nardini, Christine

Published
2022
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5. A geroscience approach for Parkinson’s disease: Conceptual framework and design of PROPAG-AGEING project

Author

Adarmes-Gómez, Astrid, Azevedo, Tiago, Bacalini, Maria Giulia, Baldelli, Luca, Bartoletti-Stella, Anna, Bhatia, Kailash P., Bonilla-Toribio, Marta, Boninsegna, Claudia, Broli, Marcella, Buiza-Rueda, Dolores, Calandra-Buonaura, Giovanna, Capellari, Sabina, Carrión-Claro, Mario, Cilea, Rosalia, Clayton, Robert, Cortelli, Pietro, Molin, Alessandra Dal, De Luca, Silvia, De Massis, Patrizia, Dimitri, Giovanna Maria, Doykov, Ivan, Escuela-Martin, Rocio, Fabbri, Giovanni, Franceschi, Claudio, Gabellini, Anna, Garagnani, Paolo, Giuliani, Cristina, Gómez-Garre, Pilar, Guaraldi, Pietro, Hägg, Sara, Hällqvist, Jenny, Halsband, Claire, Heywood, Wendy, Houlden, Henry, Huertas, Ismae, Jesús, Silvia, Jylhävä, Juulia, Labrador-Espinosa, Miguel A., Licari, Cristina, Liò, Pietro, Luchinat, Claudio, Macias, Daniel, Macrì, Stefania, Magrinelli, Francesca, Rodríguez, Juan Francisco Martín, Delledonne, Massimo, Maturo, Maria Giovanna, Mengozzi, Giacomo, Meoni, Gaia, Mignani, Francesco, Milazzo, Maddalena, Mills, Kevin, Mir, Pablo, Mollenhauer, Brit, Nardini, Christine, Nassetti, Stefania Alessandra, Pedersen, Nancy L., Periñán-Tocino, Maria Teresa, Pirazzini, Chiara, Provini, Federica, Ravaioli, Francesco, Sala, Claudia, Sambati, Luisa, Scaglione, Cesa Lorella Maria, Schade, Sebastian, Schreglmann, Sebastian, Spasov, Simeon, Strom, Stephen, Tejera-Parrado, Cristina, Tenori, Leonardo, Trenkwalder, Claudia, Turano, Paola, Valzania, Franco, Ortega, Rosario Vigo, Williams, Dylan, Xumerle, Luciano, Zago, Elisa, Dal Molin, Alessandra, and Kwiatkowska, Katarzyna Malgorzata

Published
2021
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8. Where are we in the implementation of tissue-specific epigenetic clocks?

Author

Sala, Claudia, primary, Di Lena, Pietro, additional, Fernandes Durso, Danielle, additional, Faria do Valle, Italo, additional, Bacalini, Maria Giulia, additional, Dall’Olio, Daniele, additional, Franceschi, Claudio, additional, Castellani, Gastone, additional, Garagnani, Paolo, additional, and Nardini, Christine, additional

Published
2024
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9. Differential Anti-Inflammatory Effects of Electrostimulation in a Standardized Setting.

Author

Di Pietro, Biagio, Villata, Simona, Dal Monego, Simeone, Degasperi, Margherita, Ghini, Veronica, Guarnieri, Tiziana, Plaksienko, Anna, Liu, Yuanhua, Pecchioli, Valentina, Manni, Luigi, Tenori, Leonardo, Licastro, Danilo, Angelini, Claudia, Napione, Lucia, Frascella, Francesca, and Nardini, Christine

Subjects
BIOLOGICAL systems, ELECTRIC stimulation, ALTERNATING currents, TRANSCRIPTOMES, FIBROBLASTS, WOUND healing
Abstract

The therapeutic usage of physical stimuli is framed in a highly heterogeneous research area, with variable levels of maturity and of translatability into clinical application. In particular, electrostimulation is deeply studied for its application on the autonomous nervous system, but less is known about the anti- inflammatory effects of such stimuli beyond the inflammatory reflex. Further, reproducibility and meta-analyses are extremely challenging, owing to the limited rationale on dosage and experimental standardization. It is specifically to address the fundamental question on the anti-inflammatory effects of electricity on biological systems, that we propose a series of controlled experiments on the effects of direct and alternate current delivered on a standardized 3D bioconstruct constituted by fibroblasts and keratinocytes in a collagen matrix, in the presence or absence of TNF- α as conventional inflammation inducer. This selected but systematic exploration, with transcriptomics backed by metabolomics at specific time points allows to obtain the first systemic overview of the biological functions at stake, highlighting the differential anti-inflammatory potential of such approaches, with promising results for 5 V direct current stimuli, correlating with the wound healing process. With our results, we wish to set the base for a rigorous systematic approach to the problem, fundamental towards future elucidations of the detailed mechanisms at stake, highlighting both the healing and damaging potential of such approaches. [ABSTRACT FROM AUTHOR]

Published
2024
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16. tidysbml: R/Bioconductor package for SBML extraction into dataframes.

Author

Paparozzi, Veronica and Nardini, Christine

Subjects
*SYSTEMS biology, *INFORMATION retrieval, *DATA extraction
Abstract

Summary We present tidysbml , an R package able to perform compartments , species , and reactions data extraction from Systems Biology Markup Language (SBML) documents (up to Level 3) in tabular data structures (i.e. R dataframes) to easily access and handle the richness of the biological information. Thanks to its output format, the package facilitates data manipulation, enabling manageable construction, and therefore analysis, of custom networks, as well as data retrieval, by means of R packages such as igraph , RCy3 , and biomaRt. Exemplar data (i.e. SBML files) are extracted from Reactome. Availability and implementation The tidysbml R package is distributed under CC BY 4.0 License and can be found publicly available in Bioconductor (https://bioconductor.org/packages/tidysbml) and on GitHub (https://github.com/veronicapaparozzi/tidysbml). [ABSTRACT FROM AUTHOR]

Published
2024
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17. methyLImp2: faster missing value estimation for DNA methylation data.

Author

Plaksienko, Anna, Lena, Pietro Di, Nardini, Christine, and Angelini, Claudia

Subjects
MISSING data (Statistics), DNA methylation, METHYLGUANINE
Abstract

Motivation methyLImp , a method we recently introduced for the missing value estimation of DNA methylation data, has demonstrated competitive performance in data imputation compared to the existing, general-purpose, approaches. However, imputation running time was considerably long and unfeasible in case of large datasets with numerous missing values. Results methyLImp2 made possible computations that were previously unfeasible. We achieved this by introducing two important modifications that have significantly reduced the original running time without sacrificing prediction performance. First, we implemented a chromosome-wise parallel version of methyLImp. This parallelization reduced the runtime by several 10-fold in our experiments. Then, to handle large datasets, we also introduced a mini-batch approach that uses only a subset of the samples for the imputation. Thus, it further reduces the running time from days to hours or even minutes in large datasets. Availability and implementation The R package methyLImp2 is under review for Bioconductor. It is currently freely available on Github https://github.com/annaplaksienko/methyLImp2. [ABSTRACT FROM AUTHOR]

Published
2024
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19. MANIA: A Gene Network Reverse Algorithm for Compounds Mode-of-Action and Genes Interactions Inference

Author

Lai, Darong, Lu, Hongtao, Lauria, Mario, di Bernardo, Diego, Nardini, Christine, Akan, Ozgur, Series editor, Bellavista, Paolo, Series editor, Cao, Jiannong, Series editor, Dressler, Falko, Series editor, Ferrari, Domenico, Series editor, Gerla, Mario, Series editor, Kobayashi, Hisashi, Series editor, Palazzo, Sergio, Series editor, Sahni, Sartaj, Series editor, Shen, Xuemin (Sherman), Series editor, Stan, Mircea, Series editor, Xiaohua, Jia, Series editor, Zomaya, Albert, Series editor, Coulson, Geoffrey, Series editor, and Zhou, Jie, editor

Published
2009
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23. Semi-automated socio-anthropologic analysis of the medical discourse on rheumatoid arthritis: Potential impact on public health

Author

Turrini, Mauro [0000-0001-8589-3271], Nardini, Christine, Candelise, Lucia, Turrini, Mauro, Addimanda, Olga, Turrini, Mauro [0000-0001-8589-3271], Nardini, Christine, Candelise, Lucia, Turrini, Mauro, and Addimanda, Olga

Abstract

[Background] The debilitating effects of noncommunicable diseases (NCDs) and the accompanying chronic inflammation represent a significant obstacle for the sustainability of our development, with efforts spreading worldwide to counteract the diffusion of NCDs, as per the United Nations Sustainable Development Goals (SDG 3). In fact, despite efforts of varied intensity in numerous directions (from innovations in biotechnology to lifestyle modifications), the incidence of NCDs remains pandemic. The present work wants to contribute to addressing this major concern, with a specific focus on the fragmentation of medical approaches, via an interdisciplinary analysis of the medical discourse, i.e. the heterogenous reporting that biomedical scientific literature uses to describe the anti-inflammatory therapeutic landscape in NCDs. The aim is to better capture the roots of this compartmentalization and the power relations existing among three segregated pharmacological, experimental and unstandardized biomedical approaches to ultimately empower collaboration beyond medical specialties and possibly tap into a more ample and effective reservoir of integrated therapeutic opportunities., [Method] Using rheumatoid arthritis (RA) as an exemplar disease, twenty-eight articles were manually translated into a nine-dimensional categorical variable of medical socio-anthropological relevance, relating in particular (but not only) to legitimacy, temporality and spatialization. This digitalized picture (9 x 28 table) of the medical discourse was further analyzed by simple automated learning approaches to identify differences and highlight commonalities among the biomedical categories., [Results] Interpretation of these results provides original insights, including suggestions to: empower scientific communication between unstandardized approaches and basic biology; promote the repurposing of non-pharmacological therapies to enhance robustness of experimental approaches; and align the spatial representation of diseases and therapies in pharmacology to effectively embrace the systemic approach promoted by modern personalized and preventive medicines. We hope this original work can expand and foster interdisciplinarity among public health stakeholders, ultimately contributing to the achievement of SDG3.

Published
2022

27. Metabolite and lipoprotein profiles reveal sex-related oxidative stress imbalance in de novo drug-naive Parkinson's disease patients

Author

Meoni, Gaia, Tenori, Leonardo, Schade, Sebastian, Licari, Cristina, Pirazzini, Chiara, Bacalini, Maria Giulia, Garagnani, Paolo, Turano, Paola, Baldelli, Luca, Jesús, Silvia, Schreglmann, Sebastian R, Sambati, Luisa, Gómez-Garre, Pilar, Halsband, Claire, Calandra-Buonaura, Giovanna, Adarmes-Gómez, Astrid Daniela, Sixel-Döring, Friederike, Zenesini, Corrado, Bhatia, Kailash P., Cortelli, Pietro, Mollenhauer, Brit, Franceschi, Claudio, Houlden, Henry, Liò, Pietro, Luchinat, Claudio, Delledonne, Massimo, Mills, Kevin, Pedersen, Nancy L., Azevedo, Tiago, Bartoletti-Stella, Anna, Bonilla-Toribio, Marta, Buiza-Rueda, Dolores, Capellari, Sabina, Carriòn-Claro, Mario, Clayton, Robert, Dal Molin, Alessandra, Dimitri, Giovanna Maria, Doykov, Ivan, Giuliani, Cristina, Hägg, Sara, Hällqvist, Jenny, Heywood, Wendy, Huertas, Ismael, Jylhävä, Juulia, Labrador-Espinosa, Miguel A., Macias, Daniel, Magrinelli, Francesca, Rodríguez, Juan Francisco Martín, Maturo, Maria Giovanna, Mengozzi, Giacomo, Milazzo, Maddalena, Nardini, Christine, Periñán-Tocino, Maria Teresa, Ravaioli, Francesco, Sala, Claudia, Spasov, Simeon, Tejera-Parrado, Cristina, Paola, Turano, Williams, Dylan, Xumerle, Luciano, Trenkwalder, Claudia, European Commission, Meoni, Gaia, Tenori, Leonardo, Schade, Sebastian, Turano, Paola, Licari, Cristina, Pirazzini, Chiara, Bacalini, Maria Giulia, Garagnani, Paolo, PROPAG-AGEING Consortium[.., Giuliani, Cristina, Provini, Federica, Calandra Buonaura, Giovanna, Cortelli, Pietro, Capellari, Sabina, ], Trenkwalder, Claudia, Franceschi, Claudio, Mollenhauer, Brit, Luchinat, Claudio, [Meoni, Gaia] Univ Florence, Magnet Resonance Ctr CERM, Florence, Italy, [Tenori, Leonardo] Univ Florence, Magnet Resonance Ctr CERM, Florence, Italy, [Licari, Cristina] Univ Florence, Magnet Resonance Ctr CERM, Florence, Italy, [Turano, Paola] Univ Florence, Magnet Resonance Ctr CERM, Florence, Italy, [Luchinat, Claudio] Univ Florence, Magnet Resonance Ctr CERM, Florence, Italy, [Meoni, Gaia] Univ Florence, Dept Chem Ugo Schiff, Florence, Italy, [Tenori, Leonardo] Univ Florence, Dept Chem Ugo Schiff, Florence, Italy, [Licari, Cristina] Univ Florence, Dept Chem Ugo Schiff, Florence, Italy, [Turano, Paola] Univ Florence, Dept Chem Ugo Schiff, Florence, Italy, [Luchinat, Claudio] Univ Florence, Dept Chem Ugo Schiff, Florence, Italy, [Tenori, Leonardo] Consorzio Interuniv Risonanze Magnet Met Prot CIR, Florence, Italy, [Turano, Paola] Consorzio Interuniv Risonanze Magnet Met Prot CIR, Florence, Italy, [Luchinat, Claudio] Consorzio Interuniv Risonanze Magnet Met Prot CIR, Florence, Italy, [Schade, Sebastian] Univ Med Ctr Goettingen, Dept Clin Neurophysiol, Gottingen, Germany, [Pirazzini, Chiara] IRCCS Ist Sci Neurol Bologna, Bologna, Italy, [Bacalini, Maria Giulia] IRCCS Ist Sci Neurol Bologna, Bologna, Italy, [Garagnani, Paolo] Univ Bologna, Dept Expt Diagnost & Specialty Med DIMES, Bologna, Italy, [Franceschi, Claudio] Univ Bologna, Dept Expt Diagnost & Specialty Med DIMES, Bologna, Italy, [Trenkwalder, Claudia] Univ Med Ctr Goettingen, Dept Neurol & Paracelsus Elena Klin, Kassel, Germany, [Mollenhauer, Brit] Univ Med Ctr Goettingen, Dept Neurol & Paracelsus Elena Klin, Kassel, Germany, [Franceschi, Claudio] Lobachevsky Univ, Lab Syst Med Hlth Aging, Nizhnii Novgorod, Russia, [Franceschi, Claudio] Lobachevsky Univ, Dept Appl Math, Nizhnii Novgorod, Russia, Instruct-ERIC, a Landmark ESFRI project, CERM/CIRMMP Italy Centre, Horizon 2020 Framework Programme (PROPAG-AGEING), Meoni, Gaia [0000-0002-8608-4641], Tenori, Leonardo [0000-0001-6438-059X], Schade, Sebastian [0000-0002-6316-6804], Turano, Paola [0000-0002-7683-8614], Franceschi, Claudio [0000-0001-9841-6386], Luchinat, Claudio [0000-0003-2271-8921], and Apollo - University of Cambridge Repository

Subjects
Risk, Metabolites, ipoproteins, sex-related, oxidative stress imbalance, Parkinson’s disease, NMR, Parkinson's disease, Serum-cholesterol, Predictive markers, Levodopa, Cellular and Molecular Neuroscience, Plasma, RC346-429, Homocysteine, Cholesterol levels, PROPAG-AGEING Consortium, Diagnostic markers, metabolomics, Nmr, Phenotypes, Neurology, PD, Neurology. Diseases of the nervous system, Neurology (clinical), Biomarkers
Abstract

Parkinson's disease (PD) is the neurological disorder showing the greatest rise in prevalence from 1990 to 2016. Despite clinical definition criteria and a tremendous effort to develop objective biomarkers, precise diagnosis of PD is still unavailable at early stage. In recent years, an increasing number of studies have used omic methods to unveil the molecular basis of PD, providing a detailed characterization of potentially pathological alterations in various biological specimens. Metabolomics could provide useful insights to deepen our knowledge of PD aetiopathogenesis, to identify signatures that distinguish groups of patients and uncover responsive biomarkers of PD that may be significant in early detection and in tracking the disease progression and drug treatment efficacy. The present work is the first large metabolomic study based on nuclear magnetic resonance (NMR) with an independent validation cohort aiming at the serum characterization of de novo drug-naive PD patients. Here, NMR is applied to sera from large training and independent validation cohorts of German subjects. Multivariate and univariate approaches are used to infer metabolic differences that characterize the metabolite and the lipoprotein profiles of newly diagnosed de novo drug-naive PD patients also in relation to the biological sex of the subjects in the study, evidencing a more pronounced fingerprint of the pathology in male patients. The presence of a validation cohort allowed us to confirm altered levels of acetone and cholesterol in male PD patients. By comparing the metabolites and lipoproteins levels among de novo drug-naive PD patients, age- and sex-matched healthy controls, and a group of advanced PD patients, we detected several descriptors of stronger oxidative stress., This work was supported by the Horizon 2020 Framework Programme (grant number 634821, PROPAG-AGEING).

Published
2022

28. Heterogeneity of prodromal Parkinson symptoms in siblings of Parkinson disease patients

Author

Baldelli, Luca, Schade, Sebastian, Jesús, Silvia, Schreglmann, Sebastian R., Sambati, Luisa, Gómez-Garre, Pilar, Halsband, Claire, Calandra-Buonaura, Giovanna, Adarmes-Gómez, Astrid Daniela, Sixel-Döring, Friederike, Zenesini, Corrado, Pirazzini, Chiara, Garagnani, Paolo, Bacalini, Maria Giulia, Bhatia, Kailash P., Cortelli, Pietro, Mollenhauer, Brit, Franceschi, Claudio, Mir, Pablo, Trenkwalder, Claudia, Provini, Federica, Houlden, Henry, Liò, Pietro, Luchinat, Claudio, Delledonne, Massimo, Mills, Kevin, Pedersen, Nancy L., Azevedo, Tiago, Bartoletti-Stella, Anna, Bonilla-Toribio, Marta, Buiza-Rueda, Dolores, Capellari, Sabina, Carriòn-Claro, Mario, Clayton, Robert, Dal Molin, Alessandra, Dimitri, Giovanna Maria, Doykov, Ivan, Giuliani, Cristina, Hägg, Sara, Hällqvist, Jenny, Heywood, Wendy, Huertas, Ismael, Jylhävä, Juulia, Labrador-Espinosa, Miguel A., Licari, Cristina, Macias, Daniel, Magrinelli, Francesca, Rodríguez, Juan Francisco Martín, Maturo, Maria Giovanna, Mengozzi, Giacomo, Meoni, Gaia, Milazzo, Maddalena, Nardini, Christine, Periñán-Tocino, Maria Teresa, Ravaioli, Francesco, Sala, Claudia, Spasov, Simeon, Tejera-Parrado, Cristina, Tenori, Leonardo, Paola, Turano, Williams, Dylan, Xumerle, Luciano, Zago, Elisa, Broli, Marcella, De Massis, Patrizia, Escuela-Martin, Rocio, Fabbri, Giovanni, Gabellini, Anna, Guaraldi, Pietro, Macrì, Stefania, Nassetti, Stefania Alessandra, Scaglione, Cesa Lorella Maria, Valzania, Franco, Rosaria, Cilea, Mignani, Francesco, Ortega, Rosario Vigo, Boninsegna, Claudia, De Luca, Silvia, Schade, Sebastian [0000-0002-6316-6804], Gómez-Garre, Pilar [0000-0002-0437-6182], Mir, Pablo [0000-0003-1656-302X], Provini, Federica [0000-0001-9063-2658], and Apollo - University of Cambridge Repository

Subjects
692/617/375/1718, 692/53/2423, article, 692/499
Abstract

A prodromal phase of Parkinson’s disease (PD) may precede motor manifestations by decades. PD patients’ siblings are at higher risk for PD, but the prevalence and distribution of prodromal symptoms are unknown. The study objectives were (1) to assess motor and non-motor features estimating prodromal PD probability in PD siblings recruited within the European PROPAG-AGEING project; (2) to compare motor and non-motor symptoms to the well-established DeNoPa cohort. 340 PD siblings from three sites (Bologna, Seville, Kassel/Goettingen) underwent clinical and neurological evaluations of PD markers. The German part of the cohort was compared with German de novo PD patients (dnPDs) and healthy controls (CTRs) from DeNoPa. Fifteen (4.4%) siblings presented with subtle signs of motor impairment, with MDS-UPDRS-III scores not clinically different from CTRs. Symptoms of orthostatic hypotension were present in 47 siblings (13.8%), no different to CTRs (p = 0.072). No differences were found for olfaction and overall cognition; German-siblings performed worse than CTRs in visuospatial-executive and language tasks. 3/147 siblings had video-polysomnography-confirmed REM sleep behavior disorder (RBD), none was positive on the RBD Screening Questionnaire. 173/300 siblings had

Published
2021

34. Electrostimulation of a 3D in vitro skin model to activate wound healing

Author

Villata, Simona, Napione, Lucia, Baruffaldi, Désirée, Nardini, Christine, Frascella, Francesca, and Pirri, Fabrizio

Subjects
Skin model, integumentary system, in vitro model, wound healing, electrostimulation, bioprinting 3D skin
Abstract

The aim of the work is to propose a methodology for the stimulation of a 3D in vitro skin model to activate wound healing. The presented work is in the frame of the national research project, CronXCov, "Checking the CHRONIC to prevent COVid-19", devoted to understand how physiologic and inflamed skin on chip 3D models evolve upon a range of physical (e.g., electrical, mechanical, optical) stimulations, over time. Thanks to the 3D modelling, using Next Generation Sequencing and the network medicine frame of analysis to process the data, we will systematically characterize the effects of the applied stimuli, offering new insight for the exploitation of wound healing.

Published
2021

36. The evolution of personalized healthcare and the pivotal role of European regions in its implementation

Author

Turrini, Mauro [0000-0001-8589-3271], Nardini, Christine, Osmani, Venet, Cormio, Paola G, Frosini, Andrea, Turrini, Mauro, Lionis, Christos, Neumuth, Thomas, Ballensiefen, Wolfgang, Borgono, Elio, D’Errico, Gianni, Turrini, Mauro [0000-0001-8589-3271], Nardini, Christine, Osmani, Venet, Cormio, Paola G, Frosini, Andrea, Turrini, Mauro, Lionis, Christos, Neumuth, Thomas, Ballensiefen, Wolfgang, Borgono, Elio, and D’Errico, Gianni

Abstract

Personalized medicine (PM) moves at the same pace of data and technology and calls for important changes in healthcare. New players are participating, providing impulse to PM. We review the conceptual foundations for PM and personalized healthcare and their evolution through scientific publications where a clear definition and the features of the different formulations are identifiable. We then examined PM policy documents of the International Consortium for Personalised Medicine and related initiatives to understand how PM stakeholders have been changing. Regional authorities and stakeholders have joined the race to deliver personalized care and are driving toward what could be termed as the next personalized healthcare. Their role as a key stakeholder in PM is expected to be pivotal.

Published
2021

40. Evaluation of different computational methods for DNA methylation-based biological age.

Author

Lena, Pietro Di, Sala, Claudia, and Nardini, Christine

Subjects
AGE, DNA, METHYLATION, AGE factors in disease, PHYSIOLOGY
Abstract

In recent years there has been a widespread interest in researching biomarkers of aging that could predict physiological vulnerability better than chronological age. Aging, in fact, is one of the most relevant risk factors for a wide range of maladies, and molecular surrogates of this phenotype could enable better patients stratification. Among the most promising of such biomarkers is DNA methylation-based biological age. Given the potential and variety of computational implementations (epigenetic clocks), we here present a systematic review of such clocks. Furthermore, we provide a large-scale performance comparison across different tissues and diseases in terms of age prediction accuracy and age acceleration, a measure of deviance from physiology. Our analysis offers both a state-of-the-art overview of the computational techniques developed so far and a heterogeneous picture of performances, which can be helpful in orienting future research. [ABSTRACT FROM AUTHOR]

Published
2022
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41. A geroscience approach for Parkinson’s disease: Conceptual framework and design of PROPAG-AGEING project

Author

Pirazzini, Chiara, primary, Azevedo, Tiago, additional, Baldelli, Luca, additional, Bartoletti-Stella, Anna, additional, Calandra-Buonaura, Giovanna, additional, Dal Molin, Alessandra, additional, Dimitri, Giovanna Maria, additional, Doykov, Ivan, additional, Gómez-Garre, Pilar, additional, Hägg, Sara, additional, Hällqvist, Jenny, additional, Halsband, Claire, additional, Heywood, Wendy, additional, Jesús, Silvia, additional, Jylhävä, Juulia, additional, Kwiatkowska, Katarzyna Malgorzata, additional, Labrador-Espinosa, Miguel A., additional, Licari, Cristina, additional, Maturo, Maria Giovanna, additional, Mengozzi, Giacomo, additional, Meoni, Gaia, additional, Milazzo, Maddalena, additional, Periñán-Tocino, Maria Teresa, additional, Ravaioli, Francesco, additional, Sala, Claudia, additional, Sambati, Luisa, additional, Schade, Sebastian, additional, Schreglmann, Sebastian, additional, Spasov, Simeon, additional, Tenori, Leonardo, additional, Williams, Dylan, additional, Xumerle, Luciano, additional, Zago, Elisa, additional, Bhatia, Kailash P., additional, Capellari, Sabina, additional, Cortelli, Pietro, additional, Garagnani, Paolo, additional, Houlden, Henry, additional, Liò, Pietro, additional, Luchinat, Claudio, additional, Delledonne, Massimo, additional, Mills, Kevin, additional, Mir, Pablo, additional, Mollenhauer, Brit, additional, Nardini, Christine, additional, Pedersen, Nancy L., additional, Provini, Federica, additional, Strom, Stephen, additional, Trenkwalder, Claudia, additional, Turano, Paola, additional, Bacalini, Maria Giulia, additional, Franceschi, Claudio, additional, Adarmes-Gómez, Astrid, additional, Bonilla-Toribio, Marta, additional, Boninsegna, Claudia, additional, Broli, Marcella, additional, Buiza-Rueda, Dolores, additional, Carrión-Claro, Mario, additional, Cilea, Rosalia, additional, Clayton, Robert, additional, Molin, Alessandra Dal, additional, De Luca, Silvia, additional, De Massis, Patrizia, additional, Escuela-Martin, Rocio, additional, Fabbri, Giovanni, additional, Gabellini, Anna, additional, Giuliani, Cristina, additional, Guaraldi, Pietro, additional, Huertas, Ismae, additional, Macias, Daniel, additional, Macrì, Stefania, additional, Magrinelli, Francesca, additional, Rodríguez, Juan Francisco Martín, additional, Mignani, Francesco, additional, Nassetti, Stefania Alessandra, additional, Pirazzini, Chiara, additional, Scaglione, Cesa Lorella Maria, additional, Tejera-Parrado, Cristina, additional, Valzania, Franco, additional, and Ortega, Rosario Vigo, additional

Published
2021
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