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10 results on '"Nardi, Gabriele"'

3. Role of microglial extracellular vesicles in the propagation of early synaptic dysfunction in Alzheimer’s disease

Author

Gabrielli, Martina, primary, Tozzi, Francesca, additional, Falcicchia, Chiara, additional, D'Arrigo, Giulia, additional, Amoretti, Stefano, additional, Joshi, Pooja, additional, Tonoli, Elisa, additional, Rutigliano, Grazia, additional, Masini, Greta, additional, Nardi, Gabriele, additional, Battocchio, Elisabetta, additional, Zenatelli, Rossella, additional, Radeghieri, Annalisa, additional, Verderio‐Edwards, Elisabetta, additional, Ratto, Gianmichele, additional, Arancio, Ottavio, additional, Prada, Ilaria, additional, Origlia, Nicola, additional, and Verderio, Claudia, additional

Published
2023
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5. Microglial extracellular vesicles induce Alzheimer’s disease-related cortico-hippocampal network dysfunction

Author

Falcicchia, Chiara, primary, Tozzi, Francesca, additional, Gabrielli, Martina, additional, Amoretti, Stefano, additional, Masini, Greta, additional, Nardi, Gabriele, additional, Guglielmo, Stefano, additional, Ratto, Gian Michele, additional, Arancio, Ottavio, additional, Verderio, Claudia, additional, and Origlia, Nicola, additional

Published
2023
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6. Diurnal rhythm in cortical chloride homeostasis underpins functional changes in visual cortex excitability

Author

Pracucci, Enrico, primary, Graham, Robert, additional, Alberio, Laura, additional, Nardi, Gabriele, additional, Cozzolino, Olga, additional, Pasquini, Giacomo, additional, Pillai, Vinoshene, additional, Saieva, Luciano, additional, Walsh, Darren, additional, Landi, Silvia, additional, Zhang, Jinwei, additional, Trevelyan, Andrew, additional, and Ratto, Gian Michele, additional

Published
2022
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7. Trehalose Treatment in Zebrafish Model of Lafora Disease

Author

Della Vecchia, Stefania, primary, Ogi, Asahi, additional, Licitra, Rosario, additional, Abramo, Francesca, additional, Nardi, Gabriele, additional, Mero, Serena, additional, Landi, Silvia, additional, Battini, Roberta, additional, Sicca, Federico, additional, Ratto, Gian Michele, additional, Santorelli, Filippo Maria, additional, and Marchese, Maria, additional

Published
2022
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8. Diurnal variation in neuronal chloride levels and seizure susceptibility, in neocortex, reflecting changes in activity of chloride-cation-cotransporters

Author

Pracucci, Enrico, primary, Graham, Robert, additional, Alberio, Laura, additional, Nardi, Gabriele, additional, Cozzolino, Olga, additional, Pillai, Vinoshene, additional, Saieva, Luciano, additional, Walsh, Darren, additional, Landi, Silvia, additional, Zhang, Jinwei, additional, Trevelyan, Andrew J., additional, and Ratto, Gian-Michele, additional

Published
2021
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9. A Cre-amplifier to generate and detect genetic mosaicsin vivo

Author

Trovato, Francesco, primary, Parra, Riccardo, additional, Pracucci, Enrico, additional, Landi, Silvia, additional, Cozzolino, Olga, additional, Nardi, Gabriele, additional, Cruciani, Federica, additional, Mosti, Laura, additional, Cwetsch, Andrzej, additional, Cancedda, Laura, additional, Gritti, Laura, additional, Sala, Carlo, additional, Verpelli, Chiara, additional, Maset, Andrea, additional, Lodovichi, Claudia, additional, and Ratto, Gian Michele, additional

Published
2019
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10. Microglial extracellular vesicles induce Alzheimer’s disease-related cortico-hippocampal network dysfunction

Author

Chiara Falcicchia, Francesca Tozzi, Martina Gabrielli, Stefano Amoretti, Greta Masini, Gabriele Nardi, Stefano Guglielmo, Gian Michele Ratto, Ottavio Arancio, Claudia Verderio, Nicola Origlia, Falcicchia, Chiara, Tozzi, Francesca, Gabrielli, Martina, Amoretti, Stefano, Masini, Greta, Nardi, Gabriele, Guglielmo, Stefano, Michele Ratto, Gian, Arancio, Ottavio, Verderio, Claudia, and Origlia, Nicola

Subjects
Cellular and Molecular Neuroscience, Psychiatry and Mental health, extracellular vesicles, entorhinal cortex, Alzheimer’s disease, microglia, cortical-hippocampal network, Neurology, Settore BIO/09 - Fisiologia, Biological Psychiatry
Abstract

β-Amyloid is one of the main pathological hallmarks of Alzheimer’s disease and plays a major role in synaptic dysfunction. It has been demonstrated that β-amyloid can elicit aberrant excitatory activity in cortical-hippocampal networks, which is associated with behavioral abnormalities. However, the mechanism of the spreading of β-amyloid action within a specific circuitry has not been elucidated yet. We have previously demonstrated that the motion of microglia-derived large extracellular vesicles carrying β-amyloid, at the neuronal surface, is crucial for the initiation and propagation of synaptic dysfunction along the entorhinal-hippocampal circuit. Here, using chronic EEG recordings, we show that a single injection of extracellular vesicles carrying β-amyloid into the mouse entorhinal cortex could trigger alterations in the cortical and hippocampal activity that are reminiscent of those found in Alzheimer’s disease mouse models and human patients. The development of EEG abnormalities was associated with progressive memory impairment as assessed by an associative (object-place context recognition) and non-associative (object recognition) task. Importantly, when the motility of extracellular vesicles, carrying β-amyloid, was inhibited, the effect on network stability and memory function was significantly reduced. Our model proposes a new biological mechanism based on the extracellular vesicles mediated progression of β-amyloid pathology and offers the opportunity to test pharmacological treatments targeting the early stages of Alzheimer’s disease.

Published
2023

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