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362 results on '"Nardell, Edward A."'

3. Accuracy of digital chest x-ray analysis with artificial intelligence software as a triage and screening tool in hospitalized patients being evaluated for tuberculosis in Lima, Peru

Author

Biewer, Amanda M., primary, Tzelios, Christine, additional, Tintaya, Karen, additional, Roman, Betsabe, additional, Hurwitz, Shelley, additional, Yuen, Courtney M., additional, Mitnick, Carole D., additional, Nardell, Edward, additional, Lecca, Leonid, additional, Tierney, Dylan B., additional, and Nathavitharana, Ruvandhi R., additional

Published
2024
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4. The Lancet Respiratory Medicine Commission: 2019 update: epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant and incurable tuberculosis

Author

Dheda, Keertan, Gumbo, Tawanda, Maartens, Gary, Dooley, Kelly E, Esmail, Aliasgar, Murray, Megan, Furin, Jennifer, Nardell, Edward, London, Leslie, Lessem, Erica, Limberis, Jason, Theron, Grant, McNerney, Ruth, Niemann, Stefan, Dowdy, David, Van Rie, Annelies, Pasipanodya, Jotam G, Rodrigues, Camilla, Clark, Taane G, Sirgel, Frik A, Schaaf, H Simon, Chang, Kwok Chiu, Lange, Christoph, Nahid, Payam, Fourie, Bernard, Ndjeka, Norbert, Nunn, Andrew, Migliori, GB, Udwadia, Zarir F, Horsburgh, C Robert, Jr, Churchyard, Gavin J, Menzies, Dick, Hesseling, Anneke C, Seddon, James A, Low, Marcus, Keshavjee, Salmaan, Nuermberger, Eric, McIlleron, Helen, Fennelly, Kevin P, Jindani, Amina, Jaramillo, Ernesto, Padayatchi, Nesri, Barry, Clifton E, 3rd, Warren, Robin M, and Nardell, Edward A

Published
2019
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5. 1890. Evaluating the effect of respiratory isolation for TB on patient- and public health-important outcomes- a systematic review

Author

Pearl, Abarna, primary, Biewer, Amanda M, additional, Delrooz, Naveed, additional, Subramanian, Advaith, additional, Miller, Sarah E, additional, Mukasa, Leonard, additional, Young, Laura R, additional, Mase, Sundari R, additional, Munsiff, Sonal, additional, Nardell, Edward, additional, and Nathavitharana, Ruvandhi, additional

Published
2023
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10. Inhaling to Mitigate Exhaled Bioaerosols

Author

Edwards, David A., Man, Jonathan C., Brand, Peter, Katstra, Jeffrey P., Sommerer, K., Stone, Howard A., Nardell, Edward, Scheuch, Gerhard, and Brenner, Howard

Published
2004

11. Accuracy of digital chest x-ray analysis with artificial intelligence software as a triage and screening tool in hospitalized patients being evaluated for tuberculosis in Lima, Peru.

Author

Biewer, Amanda MacNeil, primary, Tzelios, Christine, additional, Tintaya, Karen, additional, Roman, Betsabe, additional, Hurwitz, Shelley, additional, Yuen, Courtney, additional, Mitnick, Carole D., additional, Nardell, Edward, additional, Lecca, Leonid, additional, Tierney, Dylan B., additional, and Nathavitharana, Ruvandhi R., additional

Published
2023
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14. The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis

Author

Dheda, Keertan, Gumbo, Tawanda, Maartens, Gary, Dooley, Kelly E, McNerney, Ruth, Murray, Megan, Furin, Jennifer, Nardell, Edward A, London, Leslie, Lessem, Erica, Theron, Grant, van Helden, Paul, Niemann, Stefan, Merker, Matthias, Dowdy, David, Van Rie, Annelies, Siu, Gilman K H, Pasipanodya, Jotam G, Rodrigues, Camilla, Clark, Taane G, Sirgel, Frik A, Esmail, Aliasgar, Lin, Hsien-Ho, Atre, Sachin R, Schaaf, H Simon, Chang, Kwok Chiu, Lange, Christoph, Nahid, Payam, Udwadia, Zarir F, Horsburgh, C Robert, Jr, Churchyard, Gavin J, Menzies, Dick, Hesseling, Anneke C, Nuermberger, Eric, McIlleron, Helen, Fennelly, Kevin P, Goemaere, Eric, Jaramillo, Ernesto, Low, Marcus, Jara, Carolina Morán, Padayatchi, Nesri, and Warren, Robin M

Published
2017
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18. Tuberculosis

Author

Bloom, Barry R., primary, Atun, Rifat, additional, Cohen, Ted, additional, Dye, Christopher, additional, Fraser, Hamish, additional, Gomez, Gabriela B., additional, Knight, Gwen, additional, Murray, Megan, additional, Nardell, Edward, additional, Rubin, Eric, additional, Salomon, Joshua, additional, Vassall, Anna, additional, Volchenkov, Grigory, additional, White, Richard, additional, Wilson, Douglas, additional, and Yadav, Prashant, additional

Published
2017
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20. We Have the Technology to Stop Superspreading Without Masks

Author

Milton, Donald K., Nardell, Edward A., and Michaels, David

Subjects
Coronavirus infections -- Health aspects, Infection -- Health aspects, Occupational health and safety -- Health aspects, Coronaviruses -- Health aspects, General interest
Abstract

Byline: Donald K. Milton, Edward A. Nardell and David Michaels At every stage of the pandemic, a disproportionate number of coronavirus infections have been traced to a relatively small number [...]

Published
2022

21. Host-Directed Therapies for Posttuberculosis Lung Disease.

Author

Gupte, Akshay N. and Nardell, Edward A.

Subjects
DRUG therapy for tuberculosis, TUBERCULOSIS complications, PULMONARY function tests, TREATMENT effectiveness, PNEUMOTHORAX, LUNG diseases, PATIENT aftercare
Abstract

Pulmonary medicine began on tuberculosis wards in the preantibiotic era. Its first practitioners were often themselves physician victims of tuberculosis, observing its effects on their own breathing and that of other patients. Not only were lungs damaged by smoldering tuberculosis itself but by the more radical treatments of the time, including pneumothorax and plombage procedures (methods for collapsing lungs to close cavities) and excisional surgery. Such procedures required pretreatment risk assessment of lung function, resulting in pulmonary function testing, and posttreatment management of often worsened lung function. However, with the introduction of effective chemotherapy in the midtwentieth century, tuberculosis elimination was predicted, and a public health approach focused on making widely available standardized diagnosis, treatment, and bacteriologic assessment of cure. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Far-UVC: Technology Update with an Untapped Potential to Mitigate Airborne Infections.

Author

de Mesquita, P. Jacob Bueno, Sokas, Rosemary K., Rice, Mary B., and Nardell, Edward A.

Subjects
AIRBORNE infection, ULTRAVIOLET radiation, COMMENCEMENT ceremonies
Abstract

The article focuses on the need for effective strategies to prevent respiratory infections transmitted through shared indoor air, emphasizing the role of air filtration, ventilation, and germicidal UV light (GUV) in reducing airborne pathogen exposure. It highlights the efficacy of GUV, particularly far-UVC light with shorter wavelengths (222 nm), in providing efficient air disinfection in occupied spaces, with potential advantages over traditional methods like ventilation and filtration.

Published
2023
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34. FAST tuberculosis transmission control strategy speeds the start of tuberculosis treatment at a general hospital in Lima, Peru

Author

Tierney, Dylan B., primary, Orvis, Eli, additional, Nathavitharana, Ruvandhi R., additional, Hurwitz, Shelley, additional, Tintaya, Karen, additional, Vargas, Dante, additional, Segura, Patricia, additional, de la Gala, Silvana, additional, Lecca, Leonid, additional, Mitnick, Carole D., additional, and Nardell, Edward A., additional

Published
2021
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36. “If I’ve got latent TB, I would like to get rid of it”: Derivation of the CARD (Constraints, Actions, Risks, and Desires) Framework informed by South African healthcare worker perspectives on latent tuberculosis treatment

Author

Nathavitharana, Ruvandhi R., primary, van der Westhuizen, Ananja, additional, van der Westhuizen, Helene-Mari, additional, Mishra, Hridesh, additional, Sampson, Annalean, additional, Meintjes, Jack, additional, Nardell, Edward, additional, McDowell, Andrew, additional, and Theron, Grant, additional

Published
2021
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37. Molecular epidemiology of tuberculosis: achievements and challenges to current knowledge

Author

Murray Megan and Nardell Edward

Subjects
Mycobacterium tuberculosis/genetics, Mycobacterium tuberculosis/transmission, Tuberculosis/epidemiology, Epidemiology, Molecular, DNA fingerprinting/utilization, Tuberculosis, Multidrug-resistant/transmission, Risk factors, Cost of illness, Review literature, Public aspects of medicine, RA1-1270
Abstract

Over the past 10 years, molecular methods have become available with which to strain-type Mycobacterium tuberculosis. They have allowed researchers to study certain important but previously unresolved issues in the epidemiology of tuberculosis (TB). For example, some unsuspected microepidemics have been revealed and it has been shown that the relative contribution of recently acquired disease to the TB burden in many settings is far greater than had been thought. These findings have led to the strengthening of TB control. Other research has demonstrated the existence and described the frequency of exogenous reinfection in areas of high incidence. Much recent work has focused on the phenotypic variation among strains and has evaluated the relative transmissibility, virulence, and immunogenicity of different lineages of the organism. We summarize the recent achievements in TB epidemiology associated with the introduction of DNA fingerprinting techniques, and consider the implications of this technology for the design and analysis of epidemiological studies.

Published
2002

38. Discussion

Author

Espinal Marcos A., Zaleski Richard, Suárez Pedro Guillermo, Cullinan Tim, Tupasi Thelma, Jim Yong Kim, Mitnick Carole D., Bayona Jaime, Blank Ross, Nardell Edward A., Mukherjee Joia S., Rich Michael, Farmer Paul, Becerra Mercedes C., Murray Megan, Rieder Hans L., and Weezenbeek Catharina S.B. Lambregts-van

Subjects
Public aspects of medicine, RA1-1270
Published
2002

46. FAST tuberculosis transmission control strategy speeds the start of tuberculosis treatment at a general hospital in Lima, Peru

Author

Tierney, Dylan B., Orvis, Eli, Nathavitharana, Ruvandhi R., Hurwitz, Shelley, Tintaya, Karen, Vargas, Dante, Segura, Patricia, de la Gala, Silvana, Lecca, Leonid, Mitnick, Carole D., and Nardell, Edward A.

Abstract

AbstractObjective:To evaluate the effect of the FAST (Find cases Actively, Separate safely, Treat effectively) strategy on time to tuberculosis diagnosis and treatment for patients at a general hospital in a tuberculosis-endemic setting.Design:Prospective cohort study with historical controls.Participants:Patients diagnosed with pulmonary tuberculosis during hospitalization at Hospital Nacional Hipolito Unanue in Lima, Peru.Methods:The FAST strategy was implemented from July 24, 2016, to December 31, 2019. We compared the proportion of patients with drug susceptibility testing and tuberculosis treatment during FAST to the 6-month period prior to FAST. Times to diagnosis and tuberculosis treatment were also compared using Kaplan-Meier plots and Cox regressions.Results:We analyzed 75 patients diagnosed with pulmonary tuberculosis through FAST. The historical cohort comprised 76 patients. More FAST patients underwent drug susceptibility testing (98.7% vs 57.8%; OR, 53.8; P< .001), which led to the diagnosis of drug-resistant tuberculosis in 18 (24.3%) of 74 of the prospective cohort and 4 (9%) of 44 of the historical cohort (OR, 3.2; P= .03). Overall, 55 FAST patients (73.3%) started tuberculosis treatment during hospitalization compared to 39 (51.3%) controls (OR, 2.44; P= .012). FAST reduced the time from hospital admission to the start of TB treatment (HR, 2.11; 95% CI, 1.39–3.21; P< .001).Conclusions:Using the FAST strategy improved the diagnosis of drug-resistant tuberculosis and the likelihood and speed of starting treatment among patients with pulmonary tuberculosis at a general hospital in a tuberculosis-endemic setting. In these settings, the FAST strategy should be considered to reduce tuberculosis transmission while simultaneously improving the quality of care.

Published
2022
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47. Case 22-2004: a 30-year-old woman with a pericardial effusion

Author

Nardell, Edward A., Fan, Dali, Shepard, Jo-Anne O, and Mark, Eugene J.

Subjects
Pericardial effusion -- Diagnosis, Pericardial effusion -- Case studies, Women -- Health aspects, Women -- Case studies
Abstract

A 30 year old woman studying to be a physician, who had traveled to Nairobi for a month long medical rotation was found to have pericardial effusion. She believes that the skin test for tuberculosis, taken after her return from Nairobi, which was declared negative, may have been misdiagnosed.

Published
2004

48. Estimated costs of false laboratory diagnoses of tuberculosis in three patients. (Tuberculosis Genotyping Network)

Author

Northrup, Jill M., Miller, Ann C., Nardell, Edward, Sharnprapai, Sharon, Etkind, Sue, Driscoll, Jeffrey, McGarry, Michael, Taber, Harry W., Elvin, Paul, Quails, Noreen L., and Braden, Christopher R.

Subjects
Company business management, Tuberculosis -- Testing, Diagnosis -- Management, Diagnosis -- Evaluation, Medical laboratories -- Management
Abstract

We estimated direct medical and nonmedical costs associated with a false diagnosis of tuberculosis (TB) caused by laboratory cross-contamination of Mycobacterium tuberculosis cultures in Massachusetts in 1998 and 1999. For [...]

Published
2002

49. Genotyping analyses of tuberculosis cases in U.S.-and foreign-born Massachusetts residents. (Tuberculosis Genotyping Network)

Author

Sharnprapai, Sharon, Miller, Ann C., Suruki, Robert, Corkren, Edward, Etkind, Sue, Driscoll, Jeffrey, McGarry, Michael, and Nardell, Edward

Subjects
Tuberculosis -- Testing, Tuberculosis -- Research, Genotype -- Usage, Epidemiology -- Usage, Massachusetts -- Health aspects
Abstract

We used molecular genotyping to further understand the epidemiology and transmission patterns of tuberculosis (TB) in Massachusetts. The study population included 983 TB patients whose cases were verified by the [...]

Published
2002

50. Impact of genotyping of Mycobacterium tuberculosis on Public Health Practice in Massachusetts. (Tuberculosis Genotyping Network)

Author

Miller, Ann C., Sharnprapai, Sharon, Suruki, Robert, Corkren, Edward, Nardell, Edward A., Driscoll, Jeffrey R., McGarry, Michael, Taber, Harry, and Etkind, Sue

Subjects
Public health -- Research, Tuberculosis -- Genetic aspects, Tuberculosis -- Research, Genotype -- Usage, Mycobacteria -- Genetic aspects, Mycobacteria -- Research, Mycobacterium, Epidemiology
Abstract

Massachusetts was one of seven sentinel surveillance sites in the National Tuberculosis Genotyping and Surveillance Network. From 1996 through 2000, isolates from new patients with tuberculosis (TB) underwent genotyping. We [...]

Published
2002

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