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1. Role of Sulfonylurea Receptor 1 and Glibenclamide in Traumatic Brain Injury: A Review of the Evidence.

Author

Jha, Ruchira M, Bell, Josh, Citerio, Giuseppe, Hemphill, J Claude, Kimberly, W Taylor, Narayan, Raj K, Sahuquillo, Juan, Sheth, Kevin N, and Simard, J Marc

Subjects
Animals, Humans, Glyburide, TRPM Cation Channels, Clinical Trials as Topic, Genetic Variation, Sulfonylurea Receptors, Brain Injuries, Traumatic, ASTRAL, SUR1, TBI, TRPM4, cerebral edema, contusion expansion, glibenclamide, glyburide, Brain Injuries, Traumatic, Other Chemical Sciences, Genetics, Other Biological Sciences, Chemical Physics
Abstract

Cerebral edema and contusion expansion are major determinants of morbidity and mortality after TBI. Current treatment options are reactive, suboptimal and associated with significant side effects. First discovered in models of focal cerebral ischemia, there is increasing evidence that the sulfonylurea receptor 1 (SUR1)-Transient receptor potential melastatin 4 (TRPM4) channel plays a key role in these critical secondary injury processes after TBI. Targeted SUR1-TRPM4 channel inhibition with glibenclamide has been shown to reduce edema and progression of hemorrhage, particularly in preclinical models of contusional TBI. Results from small clinical trials evaluating glibenclamide in TBI have been encouraging. A Phase-2 study evaluating the safety and efficacy of intravenous glibenclamide (BIIB093) in brain contusion is actively enrolling subjects. In this comprehensive narrative review, we summarize the molecular basis of SUR1-TRPM4 related pathology and discuss TBI-specific expression patterns, biomarker potential, genetic variation, preclinical experiments, and clinical studies evaluating the utility of treatment with glibenclamide in this disease.

Published
2020

11. List of Contributors

Author

Aghi, Manish K., primary, Ali, Zarina S., additional, Altschul, Dorothea, additional, Anastasian, Zirka H., additional, Ansari, Safdar, additional, Ares, William J., additional, Attiah, Mark, additional, Avellino, Anthony M., additional, Avitsian, Rafi, additional, Badjatia, Neeraj, additional, Bailey, Robert L., additional, Bastidas, Nicholas, additional, Bhalla, Paulomi, additional, Bhimraj, Adarsh, additional, Billingsley, Joshua T., additional, Bleck, Thomas P., additional, Boone, Christine, additional, Brem, Steven, additional, Buch, Vivek, additional, Byrne, Richard W., additional, Cahill, Daniel P., additional, Caplan, Justin M., additional, Chalouhi, Nohra, additional, Chang, Catherine S., additional, Chang, Jason J., additional, Chang, Steven D., additional, Chaudhary, Navjot, additional, Isaac Chen, H., additional, Chesnut, Randall M., additional, Chiocca, E. Antonio, additional, Chitale, Rohan, additional, Clavijo, Claudia F., additional, Curry, William T., additional, Dailey, Andrew, additional, Damani, Rahul, additional, DiLorenzo, Daniel J., additional, Dowd, Christopher F., additional, Eskanadar, Emad N., additional, Evans, James J., additional, Fahy, Brenda G., additional, Farrell, Christopher J., additional, Finley Caulfield, Anna K., additional, Flexman, Alana M., additional, Furtado, Sunil V., additional, Gamble, Alexander J., additional, Gardner, Paul A., additional, Gaudet, John G., additional, Gilmore, Emily J., additional, Goodwin, C. Rory, additional, Gormley, William B., additional, Sean Grady, M., additional, Grandhi, Ramesh, additional, Gruenbaum, Benjamin F., additional, Gruenbaum, Shaun E., additional, Harrop, James S., additional, Hemphill, J. Claude, additional, Herrington, Todd M., additional, Hirsch, Lawrence J., additional, Hobbs, Kyle S., additional, Hoh, Brian L., additional, Hu, Yin C., additional, Huang, Christina, additional, Huang, Judy, additional, Hurst, Robert W., additional, Ivan, Michael E., additional, Jabbour, Pascal, additional, Kaminsky, Ian, additional, Kanchwala, Suhail, additional, Kapinos, Gregory, additional, Kilburg, Craig, additional, Kla, Koffi M., additional, Kofke, W. Andrew, additional, Kung, David, additional, Lang, Shih-Shan, additional, Lavine, Sean D., additional, Le Roux, Peter, additional, Lee, Lorri A., additional, Lew, Vincent, additional, Loomis, Caitlin, additional, Lucas, Timothy, additional, Kevin Luk, K.H., additional, Ma, Tracy S., additional, Mac Grory, Brian, additional, Macyszyn, Luke, additional, Magill, Stephen T., additional, Manley, Geoffrey T., additional, Manno, Edward M., additional, Marupudi, Neena I., additional, Masoud, Hesham, additional, Maulucci, Christopher M., additional, Melinosky, Christopher, additional, Miller, Jennifer Gutwald, additional, Molyneaux, Bradley J., additional, Moore, Bryan, additional, Musolino, Patricia L., additional, Narayan, Raj K., additional, Narayanan, Sandra, additional, Naval, Neeraj, additional, Nguyen, Cuong, additional, Nguyen, Peggy, additional, Nguyen, Thanh, additional, Nogueira, Raul G., additional, Norbash, Alexander, additional, Okonkwo, David, additional, Oppenlander, Mark E., additional, Ortega Gutierrez, Santiago, additional, Pukenas, Bryan A., additional, Quiñones-Hinojosa, Alfredo, additional, Ramchand, Preethi, additional, Rincon-Torroella, Jordina, additional, Rosand, Jonathan, additional, Rosenwasser, Robert H., additional, Rutledge, W. Caleb, additional, Schlichter, R. Alexander, additional, Schuster, James M., additional, Sciubba, Daniel M., additional, Scott, Benjamin K., additional, Pokmeng See, Alfred, additional, Shankar, Ganesh M., additional, Shapira, Yoram, additional, Sharma, Deepak, additional, Sheth, Kevin N., additional, Shutter, Lori A., additional, Siegler, James E., additional, Smith, Michelle J., additional, Snyderman, Carl H., additional, Steinberg, Gary K., additional, Stiefel, Michael F., additional, Stricsek, Geoffrey P., additional, Suarez, Jose I., additional, Sung, Gene, additional, Syre, Peter, additional, Talke, Pekka O., additional, Tamargo, Rafael J., additional, Taylor, Robert, additional, Tewari, Anurag, additional, Tjoumakaris, Stavropoula, additional, Venkatasubramanian, Chitra, additional, Venteicher, Andrew S., additional, Weinstein, Michael S., additional, White, Peggy, additional, Wilson, Anthony J., additional, Wright, James M., additional, Yi, Debbie, additional, Zadnik, Patricia, additional, Zager, Eric L., additional, Zanaty, Mario, additional, and Zlotnik, Alexander, additional

Published
2018
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13. Traumatic Brain Injury

Author

Chakraborty, Shamik, primary, Skolnick, Brett E., additional, Alves, Wayne M., additional, Marshall, Lawrence F., additional, and Narayan, Raj K., additional

Published
2018
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14. List of Contributors

Author

Alves, Timothy I., primary, Alves, Wayne M., additional, Bakken, Hans, additional, Balcer, Laura J., additional, Berk, Thomas, additional, Bladin, Christopher F., additional, Bleck, Thomas P., additional, Campbell, Bruce C.V., additional, Chakraborty, Shamik, additional, Davis, Stephen M., additional, Donnan, Geoffrey A., additional, Draghic, Nicole, additional, Ecklund, James, additional, Glushakov, Alexander V., additional, Glushakova, Olena Y., additional, Goyal, Mayank, additional, Greenberg, Jared A., additional, Grimes, Jamie, additional, Hainline, Clotilde, additional, Hayes, Ronald L., additional, Herman, Susan T., additional, Hill, Michael D., additional, Holodinsky, Jessalyn K., additional, Johnson, Steven B., additional, Kolls, Brad J., additional, Laskowitz, Daniel T., additional, Levy, Howard, additional, Ling, Geoffrey, additional, Lloyd-Smith, Alexandra, additional, Maas, Andrew I.R., additional, Macdonald, Robert Loch, additional, Mannix, Rebekah, additional, Marshall, Lawrence F., additional, Mayer, Stephan A., additional, Menon, David K., additional, Miller, Emmy R., additional, Narayan, Raj K., additional, Palesch, Yuko Y., additional, Rincon, Fred, additional, Rucker, Janet C., additional, Silberstein, Stephen D., additional, Skolnick, Brett E., additional, Tamhankar, Madhura A., additional, Temkin, Nancy, additional, Valadka, Alex B., additional, Wintermark, Max, additional, Yeatts, Sharon D., additional, and Zerna, Charlotte, additional

Published
2018
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20. Abstract 3379: Multi-cohort study shows HCC is associated with a relative regional reduction in TGFBR2 in liver biopsies from patients with cirrhosis

Author

Bhowmick, Krishanu, primary, Amdur, Richard, additional, Xiang, Xiyan, additional, Yu, Herbert, additional, Wong, Linda L., additional, Rao, Shuyun, additional, He, Aiwu R., additional, Amin, Karan, additional, Zaheer, Daewa, additional, Narayan, Raj K., additional, Satapathy, Sanjaya K., additional, Guha, Chandan, additional, Latham, Patricia S., additional, Shetty, Kirti, additional, Gough, Nancy R., additional, and Mishra, Lopa, additional

Published
2022
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21. Using quantitative immunohistochemistry in patients at high risk for hepatocellular cancer

Author

Zaidi, Sobia, primary, Amdur, Richard, additional, Xiang, Xiyan, additional, Yu, Herbert, additional, Wong, Linda L., additional, Rao, Shuyun, additional, He, Aiwu R., additional, Amin, Karan, additional, Zaheer, Daewa, additional, Narayan, Raj K., additional, Satapathy, Sanjaya K., additional, Latham, Patricia S., additional, Shetty, Kirti, additional, Guha, Chandan, additional, Gough, Nancy R., additional, and Mishra, Lopa, additional

Published
2022
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38. CBF Oscillations Induced by Trigeminal Nerve Stimulation Protect the Pericontusional Penumbra in Traumatic Brain Injury Complicated By Hemorrhagic Shock

Author

Li, Chunyan, primary, Shah, Kevin A., additional, Powell, Keren, additional, Wu, Yi-Chen, additional, Chaung, Wayne, additional, Sonti, Anup, additional, White, Timothy G., additional, Doobay, Mohini, additional, Yang, Weng-Lang, additional, Wang, Ping, additional, Becker, Lance B., additional, and Narayan, Raj K., additional

Published
2021
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40. Role of Sulfonylurea Receptor 1 and Glibenclamide in Traumatic Brain Injury: A Review of the Evidence

Author

Jha, R, Bell, J, Citerio, G, Hemphill, J, Kimberly, W, Narayan, R, Sahuquillo, J, Sheth, K, Simard, J, Jha, Ruchira M., Bell, Josh, Citerio, Giuseppe, Hemphill, J. Claude, Kimberly, W. Taylor, Narayan, Raj K., Sahuquillo, Juan, Sheth, Kevin N., Simard, J. Marc, Jha, R, Bell, J, Citerio, G, Hemphill, J, Kimberly, W, Narayan, R, Sahuquillo, J, Sheth, K, Simard, J, Jha, Ruchira M., Bell, Josh, Citerio, Giuseppe, Hemphill, J. Claude, Kimberly, W. Taylor, Narayan, Raj K., Sahuquillo, Juan, Sheth, Kevin N., and Simard, J. Marc

Abstract

Cerebral edema and contusion expansion are major determinants of morbidity and mortality after TBI. Current treatment options are reactive, suboptimal and associated with significant side effects. First discovered in models of focal cerebral ischemia, there is increasing evidence that the sulfonylurea receptor 1 (SUR1)—Transient receptor potential melastatin 4 (TRPM4) channel plays a key role in these critical secondary injury processes after TBI. Targeted SUR1-TRPM4 channel inhibition with glibenclamide has been shown to reduce edema and progression of hemorrhage, particularly in preclinical models of contusional TBI. Results from small clinical trials evaluating glibenclamide in TBI have been encouraging. A Phase-2 study evaluating the safety and efficacy of intravenous glibenclamide (BIIB093) in brain contusion is actively enrolling subjects. In this comprehensive narrative review, we summarize the molecular basis of SUR1-TRPM4 related pathology and discuss TBI-specific expression patterns, biomarker potential, genetic variation, preclinical experiments, and clinical studies evaluating the utility of treatment with glibenclamide in this disease.

Published
2020

41. Role of Sulfonylurea Receptor 1 and Glibenclamide in Traumatic Brain Injury : A Review of the Evidence

Author

Jha, Ruchira M., Bell, Josh, Citerio, Giuseppe, Hemphill, J. Claude, Kimberly, W. Taylor, Narayan, Raj K., Sahuquillo Barris, Juan, Sheth, Kevin N., Simard, J. Marc, Universitat Autònoma de Barcelona, Jha, Ruchira M., Bell, Josh, Citerio, Giuseppe, Hemphill, J. Claude, Kimberly, W. Taylor, Narayan, Raj K., Sahuquillo Barris, Juan, Sheth, Kevin N., Simard, J. Marc, and Universitat Autònoma de Barcelona

Abstract

Cerebral edema and contusion expansion are major determinants of morbidity and mortality after TBI. Current treatment options are reactive, suboptimal and associated with significant side effects. First discovered in models of focal cerebral ischemia, there is increasing evidence that the sulfonylurea receptor 1 (SUR1)-Transient receptor potential melastatin 4 (TRPM4) channel plays a key role in these critical secondary injury processes after TBI. Targeted SUR1-TRPM4 channel inhibition with glibenclamide has been shown to reduce edema and progression of hemorrhage, particularly in preclinical models of contusional TBI. Results from small clinical trials evaluating glibenclamide in TBI have been encouraging. A Phase-2 study evaluating the safety and efficacy of intravenous glibenclamide (BIIB093) in brain contusion is actively enrolling subjects. In this comprehensive narrative review, we summarize the molecular basis of SUR1-TRPM4 related pathology and discuss TBI-specific expression patterns, biomarker potential, genetic variation, preclinical experiments, and clinical studies evaluating the utility of treatment with glibenclamide in this disease

Published
2020

42. Artificial Intelligence for Replacing Manual Protein Abundance Assessment in Cirrhotic and Liver Cancer Tissue Samples

Author

Zaidi, Sobia, primary, Amdur, Richard, additional, Xiang, Xiyan, additional, Yu, Herbert, additional, Wong, Linda L., additional, Rao, Shuyun, additional, He, Aiwu Ruth, additional, Amin, Karan, additional, Zaheer, Daewa, additional, Narayan, Raj K., additional, Satapathy, Sanjaya K., additional, Guha, Chandan, additional, Latham, Patricia S., additional, Shetty, Kirti, additional, Gough, Nancy R., additional, and Mishra, Lopa, additional

Published
2021
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44. Portable MRI for the Neurosurgical ICU

Author

Turpin, Justin, primary, Unadkat, Prashin, additional, Thomas, Justin G, additional, Kleiner, Nick, additional, Khazanehdari, Shahab, additional, Wanchoo, Sheshali, additional, Samuel, Kenia, additional, Moclair, Betsy, additional, Black, Karen, additional, Dehdashti, Amir R, additional, Narayan, Raj K, additional, Temes, Richard, additional, and Schulder, Michael, additional

Published
2020
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45. Surgical Prioritization

Author

Thomas, Justin G, primary, Gandhi, Shashank V, additional, White, Timothy G, additional, Jocelyn, Christian, additional, Soo, Teck M, additional, Eisenberg, Mark B, additional, Schulder, Michael, additional, and Narayan, Raj K, additional

Published
2020
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46. Cerebrospinal fluid macrophage migration inhibitory factor: a potential predictor of cerebral vasospasm and clinical outcome after aneurysmal subarachnoid hemorrhage

Author

Kwan, Kevin, primary, Arapi, Orseola, additional, Wagner, Katherine E., additional, Schneider, Julia, additional, Sy, Heustein L., additional, Ward, Mary Frances, additional, Sison, Cristina P., additional, Li, Chunyan, additional, Eisenberg, Mark B., additional, Chalif, David, additional, Narayan, Raj K., additional, Miller, Edmund J., additional, and Ledoux, David, additional

Published
2020
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48. Contributors

Author

Abdulrauf, Saleem I., primary, Acerbi, Francesco, additional, Appelboom, Geoffrey, additional, Armonda, Rocco A., additional, Balériaux, Danielle, additional, Bambakidis, Nicholas C., additional, Batjer, H. Hunt, additional, Bauman, Joel A., additional, Bell, LCDR Randy S., additional, Belverud, Shawn A., additional, Bendok, Bernard R., additional, Benzel, Edward C., additional, Berger, Mitchel S., additional, Bhangoo, Sandeep S., additional, Bingaman, William, additional, Black, Peter, additional, Blondel, Benjamin, additional, Broggi, Giovanni, additional, Broggi, Morgan, additional, Brotchi, Jacques, additional, Browd, Samuel R., additional, Bruneau, Michaël, additional, Cadotte, David W., additional, Cappabianca, Paolo, additional, Carrau, Ricardo L., additional, Cavallo, Luigi Maria, additional, Celix, Juanita M., additional, Cifarelli, Chris, additional, Cirivello, Lt. Michael, additional, Cohen, Alan R., additional, Connolly, E. Sander, additional, Correa-Correa, Victor, additional, Darbar, Aneela, additional, Di Maio, Salvatore, additional, Eddleman, Christopher S., additional, Ellenbogen, Richard G., additional, Eller, Jorge L., additional, Esposito, Felice, additional, Esposito, Isabella, additional, Fallah, Aria, additional, Fehlings, Michael G., additional, Ferreira, Manuel, additional, Filippidis, Aristotelis S., additional, Fink, James R., additional, Tozer Fink, Kathleen R., additional, Flickinger, John C., additional, Garcia, Rabindranath, additional, Geisler, Fred H., additional, Gelfenbeyn, Mikhail, additional, Gerganov, Venelin M., additional, Getch, Christopher C., additional, Ghobrial, George M., additional, Giussani, Carlo, additional, Goel, Atul, additional, Gokaslan, Ziya L., additional, Goodrich, James Tait, additional, Grant, Gerald A., additional, Gunel, Murat, additional, Hankinson, Todd C., additional, Harrop, James S., additional, Hdeib, Alia, additional, Hoffer, Alan, additional, Hopkins, L. Nelson, additional, Houseman, Clifford M., additional, Hughes, Gwyneth, additional, Jimenez, David F., additional, Kalani, M. Yashar S., additional, Kassam, Amin B., additional, Keating, Robert F., additional, Kelly, Daniel, additional, Kemp, Joanna, additional, Khandekar, Melin, additional, Kim, Louis J., additional, Kondziolka, Douglas, additional, Lafage, Virginie, additional, Landriel, Federico, additional, Lapointe, Geneviève, additional, Larson, A. Noelle, additional, Laufer, Ilya, additional, Lebovitz, Jonathon J., additional, Lefranc, Florence, additional, Levitt, Michael R., additional, Levy, Elad I., additional, Liu, James K.C., additional, Loeffler, Jay, additional, Loeser, John, additional, López, Ramón López, additional, Lucas, Timothy H., additional, Lunsford, L. Dade, additional, Macyszyn, Luke J., additional, Madera, Marcella A., additional, Magge, Suresh N., additional, Malik, Ghaus M., additional, Manson, Paul N., additional, Marchan, Edward M., additional, Marras, Carlo, additional, Marsh, Henry, additional, Matula, Christian, additional, McLaughlin, Nancy, additional, Messina, Giuseppe, additional, Mantovani, Alessandra, additional, Morton, Ryan, additional, Muh, Carrie R., additional, Narayan, Raj K., additional, Natarajan, Sabareesh K., additional, Niranjan, Ajay, additional, Ojemann, Jeffrey G., additional, Oluigbo, Chima O., additional, Oyesiku, Nelson M., additional, Ozturk, Ali K., additional, Palejwala, Sheri K., additional, Piazza, Matthew, additional, Polly, David W., additional, Prevedello, Daniel M., additional, Radon, Anja-Maria, additional, Rajan, Govind, additional, Rezai, Ali R., additional, Rodriguez, Eduardo, additional, Rutka, James T., additional, Samii, Madjid, additional, Samuelson, Mical, additional, Sanai, Nader, additional, Sasaki-Adams, Deanna, additional, Savage, Jennifer Gentry, additional, Schlesinger, David, additional, Schwab, Frank, additional, Sciubba, Daniel, additional, Scott, R. Michael, additional, Sekhar, Laligam N., additional, Selman, Warren, additional, Seruya, Mitchel, additional, Sgouros, Spyros, additional, Sheehan, Jason P., additional, Shih, Helen, additional, Siddiqui, Adnan H., additional, Silbergeld, Daniel L., additional, Singer, Justin, additional, Smith, Edward R., additional, Stagno, Vita, additional, Štenˇo, Juraj, additional, Sutton, Leslie N., additional, Sweeney, Justin M., additional, Taghva, Alexander S., additional, Tariq, Farzana, additional, Teo, Charles, additional, Theodore, Nicholas, additional, Tubbs, R. Shane, additional, Two, Aimee, additional, Wait, Scott D., additional, Walter, Grace Elisabeth, additional, Weeks, Adrienne, additional, Wellons, John C., additional, Yang, Lynda J.-S., additional, and Yen, Chun Po, additional

Published
2012
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